<s>[INST] ${10 \choose 4}+{11 \choose 4}+{12 \choose 4}+\cdots+{20 \choose 4}$ can be simplified as which of the following? ${10 \choose 4}+{11 \choose 4}+{12 \choose 4}+\cdots+{20 \choose 4}$ can be simplified as ?
A. ${21 \choose 5}$
B. ${20 \choose 5}-{11 \choose 4}$
C. ${21 \choose 5}-{10 \choose 5}$
D. ${20 \choose 4}$
Please give me a hint. I'm unable to group the terms.
By brute force, I'm getting ${21 \choose 5}-{10 \choose 5}$
 [/INST] The same thing, combinatorially.  We want to choose $5$ positive integers from the first $21$. This can be done in $\binom{21}{5}$ ways.  
We count the same thing in a different way. If the biggest chosen number is $21$, the rest can be chosen in $\binom{20}{4}$ ways. If the biggest is $20$, the rest can be chosen in $\binom{19}{4}$ ways. If the biggest is $19$, the rest can be chosen in $\binom{18}{4}$ ways. And so on, until if the biggest is $5$, the rest can be chosen in $\binom{4}{4}$ ways. 
We conclude that
$$\binom{20}{4}+\binom{19}{4}+\binom{18}{4}+\cdots+\binom{10}{4}+\binom{9}{4}+\cdots +\binom{4}{4}=\binom{21}{5}. \tag{$1$}$$
The same reasoning shows that
$$\binom{9}{4}+\binom{8}{4}+\cdots+\binom{4}{4}=\binom{10}{5}. \tag{$2$}$$
Now subtract $(2)$ from $(1)$.
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