With many different types of<unk> es and causes, treatment therapies vary for each type. Many studies and clinical trials are in progress to find treatment and therapies for each of the different<unk> es. Stem cell transplants and gene therapy appear to be the most promising in treating all<unk> es providing it is done as early as possible. For hypomyelinating<unk> es, therapeutic research into cell-based therapies appears promising. Oligodendrocyte precursor cells and neural stem cells have been transplanted successfully and have shown to be healthy a year later. Fractional anisotropy and radial diffusivity maps showed possible myelination in the region of the transplant. Induced pluripotent stem cells, oligodendrocyte precursor cells, gene correction, and transplantation to promote the maturation, survival, and myelination of oligodendrocytes seem to be the primary routes for possible treatments. For three types of<unk> es (X-linked adrenoleukodystrophy (X-ALD), metachromatic<unk>  (MLD) and Krabbe Disease (globoid cell<unk>  - GLD), gene therapy using autologous hematopoietic stem cells to transfer the disease gene with lentiviral vectors have shown to be successful and are currently being used in clinical trials for X-ALD and MLD. The progression of X-ALD has shown to be disrupted with hematopoietic stem cell gene therapy but the exact reason why demyelination stops and the amount of stem cells needed is unclear. While there is an accumulation of very long chain fatty acids in the brain, it does not seem to be the reason behind the disease as gene therapy does not correct it. For those<unk> es that result from a deficiency of lysozyme enzymes, such as Krabbe disease, enzyme replacement therapy seems hopeful. However, enzyme delivery proves difficult, because the blood-brain barrier severely limits what can pass into the central nervous system. Current gene therapy research for metachromatic<unk>  has been reviewed with an emphasis on ex vivo transplantation of genetically modified hematopoietic stem cells.
Leukodystrophy
Dysthanasia
Huntington's disease-like syndrome
Metachromatic leukodystrophy
Post-encephalitic parkinsonism
Benign hereditary chorea
Acorea, microphthalmia and cataract syndrome
Non-progressive congenital ataxia