<unk>  <unk>  is an enzyme () synthesized in the liver containing 6 atoms of copper in its structure.<unk>  carries more than 95% of the total copper in healthy human plasma. The rest is accounted for by macroglobulins.<unk>  exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state. The molecular weight of human<unk>  is reported to be 151kDa. Despite extensive research, much is still unknown about the exact functions of<unk> , most of the functions are attributed to<unk>  focus on the presence of the Cu centers. These include copper transport to deliver the Cu to extrahepatic tissues, amine oxidase activity that controls the level of biogenic amines in intestinal fluids and plasma, removal of oxygen and other free radicals from plasma, and the export of iron from cells for transport through transferrin. Mutations have been known to disrupt the binding of copper to<unk>  and will disrupt iron metabolism and cause an iron overload.<unk>  is a relatively large enzyme (~10nm); the larger size prevents the bound copper from being lost in a person's urine during transport.
Ceruloplasmin
Hepcidin
Hemoglobin
Ophanin
Retinol-binding protein
Beta-2 transferrin
Ferritin
Lumirubin