<unk> s (MZ B cells) are noncirculating mature B cells that in humans segregate anatomically into the<unk> <unk>  (MZ) of the spleen and certain other types of lymphoid tissue. The MZ B cells within this region typically express low-affinity polyreactive B-cell receptors (BCR), high levels of IgM, Toll-like receptors (TLRs), CD21, CD1, CD9, CD27 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. MZ B cells are innate-like B cells specialized to mount rapid T-independent, but also T-dependent responses against blood-borne pathogens. They are also known to be the main producers of IgM antibodies in humans.
Marginal zone B-cell
Reactive lymphocyte
Follicular dendritic cells
Regulatory B cell
Memory B cell
Medullary thymic epithelial cells
Th22 cell
Tingible body macrophage