<unk>  exerts a generalized depressant effect on the central nervous system and, in very high doses, has peripheral effects.<unk>  has analgesic and antipyretic effects mediated by a metabolite that acts at cannabinoid receptors. Caffeine is thought to produce constriction of cerebral blood vessels and serves to counteract the sedative effect of<unk> .<unk>  has a half-life of about 35 hours.<unk>  has a half-life of about 1.25 to 3 hours, but may be increased by liver damage and after an overdose. Caffeine has a half-life of about 2.5 to 4.5 hours.
Butalbital/acetaminophen
Hydrocodone/paracetamol
Oxycodone/ibuprofen
Phenylephrine/ketorolac
Hydrocodone/ibuprofen
Naproxen/diphenhydramine
Hydrocodone/aspirin
Ibuprofen/paracetamol