It is used in diseases featuring high<unk> , such as the rare homozygous familial hypercholesterolemia, when the heterozygous form does not respond to medical treatment, or when the treatment has led to dangerous side-effects (such as rhabdomyolysis). The procedure takes 2–4 hours and must be repeated every several weeks to keep the<unk>  levels from accumulation and causing cardiovascular disease. It is an expensive procedure, limiting its use to severe cases of hyperlipidemia.
LDL apheresis
Cerliponase alfa
Ezetimibe/rosuvastatin
Ezetimibe/atorvastatin
Bempedoic acid/ezetimibe
Ezetimibe/simvastatin
Enzyme replacement therapy
Clofibrate