The causes of<unk>  include changes in metabolism, physiology, diet and exercise habits, obesity, sex-specific dimorphic skin architecture, alteration of connective tissue structure, hormonal factors, genetic factors, the microcirculatory system, the extracellular matrix, and subtle inflammatory alterations. Hormonal factors Hormones play a dominant role in the formation of<unk> . Estrogen may be the important hormone in the development of<unk> . However, there has been no reliable clinical evidence to support such a claim. Other hormones—including insulin, the catecholamines adrenaline and noradrenaline, thyroid hormones, and prolactin—are believed to participate in the development of<unk> . Genetic factors There is a genetic element in individual susceptibility to<unk> . Researchers have traced the genetic component of<unk>  to particular polymorphisms in the angiotensin converting enzyme (ACE) and hypoxia-inducible factor 1A (HIF1a) genes. Predisposing factors Several factors have been shown to affect the development of<unk> . Sex, ethnicity, biotype, distribution of subcutaneous fat, and predisposition to lymphatic and circulatory insufficiency have all been shown to contribute to<unk> . Lifestyle A high-stressful lifestyle causes an increase in the level of catecholamines, which have also been associated with the development of<unk> .
Cellulite
Neurite
Hermaphrodite 
Phytic acid
Cerate
Hemichrome
Melanin
Indoxyl sulfate