<unk>  surrounded by red blood cells<unk> s or variant lymphocytes are cytotoxic (CD8+) lymphocytes that become large as a result of antigen stimulation. Typically, they can be more than 30 μm in diameter with varying size and shape. The nucleus of a<unk>  can be round, elliptic, indented, cleft, or folded. The cytoplasm is often abundant and can be basophilic. Vacuoles and/or azurophilic granules are also sometimes present. Most often, the cytoplasm is gray, pale blue, or deep blue in colour. The distinctive cell associated with EBV or CMV is known as a "Downey cell", after Hal Downey, who contributed to the characterization of it in 1923. __TOC__
Reactive lymphocyte
Tingible body macrophage
Mast cell
Plasma cell
Dendritic cell
Prolymphocyte
Passenger leukocyte
Nonspecific immune cell