Similar to other nitrites and organic nitrates,<unk>  is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent sequestration of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Isosorbide dinitrate
Isosorbide mononitrate
Balsalazide
Minoxidil
Sodium nitroprusside
Telmisartan
Captopril
Nitroglycerin 