Types Type OMIM Gene Locus SMDP1 SFTPB 2p12 SMDP2 SPTPC 8p21 SMDP3 ABCA3 16p13 SMDP4 CSF2RA Xp Non-invasive genetic testing can be used to infer possible interstitial lung disorders caused by<unk> . Although these sequencing tests can take up to several weeks, which may not be so useful in case of acute respiratory problems in newborns. Overlapping phenotypes of<unk>  and other interstitial lung diseases make it hard to propose definitive diagnosis for<unk>  disorders. Overall testings, family history, external factors, and clinical presentations should all be considered to diagnose<unk> . Testing for<unk>  should be considered for newborns with diffuse lung disease or hypoxemia, especially in families with history of neonatal lung diseases or ILD in adults. Neonatal and adult onset lung diseases with unfound causes should also be tested early for<unk><unk> . ABCA3 and SP-B<unk> s manifest in newborns and progress aggressively within the first few months of life, thus, testing for ABCA3 and SP-B disorders should preclude those for SP-C, especially when infants are showing symptoms of ILD or diffuse lung disease. Distinctions between SP-B and ABCA3 are ABCA3 tends to occur in families with neonatal lung disease history, and SP-B testing almost unneeded in older children. Late on-set conditions with inheritance in dominant fashion should infer SP-C<unk> . Antibodies against proSP-B, proSP-C, SP-B, SP-C, and ABCA3 have been thoroughly developed, which makes detection for these proteins highly accessible and accurate. Immuno staining of each of these type of<unk><unk>  differs in absence and presence of specific proteins and propeptides, thus immunohistochemisty can help decipher which type of deficiency is being dealt with. In addition, hypothyroidism can cause damaged production of NKX2.1 proteins, which can lead to insufficient transcription of multiple<unk>  proteins.
Surfactant metabolism dysfunction
Congenital pulmonary airway malformation
Hypoplastic right heart syndrome
Humoral immune deficiency
Vocal cord dysfunction
Anomalous pulmonary venous connection
Hypoplastic left heart syndrome
Upper airway resistance syndrome