In 2012, a research paper showed that when activated CD4+ T cells and monocytes are in close contact, interaction of CD40-CD40L between these two cells and subsequent IFNγ secretion by the T cells causes upregulation and secretion of fusion-related molecule DC-STAMP (dendritic cell-specific transmembrane protein) by the monocytes, which results in LGC formation.
Langhans giant cell
Touton giant cell
Nevus cell
Aschoff cell
Koilocyte
Hürthle cell
Tingible body macrophage
Epithelioid cell