MDS is a microdeletion syndrome involving loss of the gene PAFAH1B1 on chromosome 17 which is responsible for the syndrome's characteristic sign of lissencephaly. The loss of another gene, YWHAE, in the same region of chromosome 17 increases the severity of the lissencephaly in patients with<unk> . Additional genes in the deleted region are likely to contribute to the varied features of<unk> . It may be a random event during the formation of reproductive cells or in early fetal development or due to familial chromosomal rearrangement called chromosomal translocation. In less than 20%, inheritance is through an autosomal dominant pattern. The parent is usually unaffected, but carries a particular chromosomal rearrangement called a balanced translocation, in which no genetic material is gained or lost. Increased rate of unexplained fetal loss may be observed in MDS carriers with balanced translocations although they may be otherwise asymptomatic. However, they can become also unbalanced as they are passed to the next generation.<unk>  is usually not inherited. The deletion event occurs randomly during gametogenesis (formation of eggs or sperm) or in early foetal development. Therefore, no history of the disorder is usually seen in their families.
Miller–Dieker syndrome
Silver–Russell syndrome
Smith–Magenis syndrome
Marshall–Smith syndrome
Laurence–Moon syndrome
Wiedemann–Steiner syndrome
Wilson–Turner syndrome
Malouf syndrome