<unk>  is a sulfonamide antibiotic that competes with p-aminobenzoic acid in the biosynthesis of folate.<unk>  serves as a selective inhibitor of protozoal dihydrofolate reductase, hence preventing the synthesis of tetrahydrofolate — the active form of folate. A great degree of synergy occurs between the two drugs due to their inhibition of two different steps in the biosynthesis of tetrahydrofolate. + Pharmacokinetics Pharmacokinetic parameter<unk> <unk>  Half-life 111 hours 169 hours Cmax 0.2 mg/l 60 mg/L Tmax 4 hours 4 hours Protein bound 87% 90% Excretion Renal (16-30%) Renal (30%) Metabolism Hepatic Hepatic
Sulfadoxine/pyrimethamine
Quinine
Artesunate/mefloquine
Praziquantel
Artesunate/amodiaquine
Doxycycline
Nifurtimox/eflornithine
Albendazole