Organs most commonly affected by haemochromatosis include the liver, heart, and endocrine glands. Haemochromatosis may present with the following clinical syndromes: * liver: chronic liver disease and cirrhosis of the liver. * heart: heart failure, cardiac arrhythmia. * hormones: diabetes (see below) and hypogonadism (insufficiency of the sex hormone producing glands) which leads to low sex drive and/or loss of fertility in men and loss of menstrual cycle in women. * metabolism: diabetes in people with<unk>  occurs as a result of selective iron deposition in islet beta cells in the pancreas leading to functional failure and cell death. * skeletal: arthritis, from calcium pyrophosphate deposition in joints leading to joint pains. The most commonly affected joints are those of the hands, particularly the knuckles of the second and third fingers. * skin: melanoderma (darkening or 'bronzing' of the skin). The skin's deep tan color, in concert with insulin insufficiency due to pancreatic damage, is the source of a nickname for this condition: "bronze diabetes" (for more information, see the history of haemochromatosis).
Iron overload
Zinc toxicity
Lead poisoning
Iron poisoning
Fluoride toxicity
Copper toxicity
Metal toxicity
Ochronosis