<unk>  (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards. It was first synthesized and characterized in 1957 by Vargha et al. The mechanism of antineoplastic activity of<unk> , like for all other alkylating agents, lies in its ability to alkylate DNA guanine nucleobases and, thus, to prevent uncoupling of DNA strands, which is a required step for any cell to divide.<unk>  was, at the time of its creation as a drug, claimed to be considerably less toxic than mechlorethamine. For example, the LD50 in rats, for intravenous<unk>  administration route, is claimed to be about 56 mg/kg.
Mannomustine
Bendamustine
Carmustine
Lomustine
Vincristine
Normustine
Ifosfamide
Busulfan