<unk>  has an autosomal recessive pattern of inheritance. Mutations in the HLCS gene cause<unk> . The HLCS gene makes an enzyme,<unk><unk> , that attaches biotin to other molecules. Biotin, a B vitamin, is found in foods such as liver, egg yolks, and milk. It is essential for the normal production and breakdown of proteins, fats, and carbohydrates in the body. Mutations in the HLCS gene reduce the activity of<unk><unk> , preventing cells from using biotin effectively and disrupting many cellular functions. This condition is inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered.
Holocarboxylase synthetase deficiency
Malonyl-CoA decarboxylase deficiency
Guanidinoacetate methyltransferase deficiency
Carbamoyl phosphate synthetase I deficiency
2,4 Dienoyl-CoA reductase deficiency
Pyruvate kinase deficiency
Ornithine translocase deficiency
Aminoacylase 1 deficiency