Inhibition<unk>  antagonists do not provoke an inflammatory response upon binding, but block or lessen the effect of<unk> . Examples of<unk>  antagonists are: * CV-3988 is a<unk>  antagonist that blocks signaling events correlated to the expression and binding of<unk>  to the<unk>  Receptor. * SM-12502 is a<unk>  antagonist, which is metabolized in the liver by the enzyme CYP2A6. * Rupatadine is an antihistamine and<unk>  antagonist used to treat allergies. * Etizolam is a benzodiazepine analog and<unk>  antagonist used to treat anxiety and panic attacks. * Apafant * Lexipafant (Zacutex) for treatment of pancreatitis. * Modipafant * A full list in a review: Clinical significance High<unk>  levels are associated with a variety of medical conditions. Some of these conditions include: •Allergic reactions •Stroke •Sepsis •Myocardial infarction •Colitis, inflammation of the large intestine •Multiple sclerosis While the effects that<unk>  has on inflammatory response and cardiovascular conditions are well understood,<unk>  is still a subject for discussion. Over the past 23 years, papers written on<unk>  have almost doubled from approximately 7,500 in 1997 to 14,500 in 2020. Research into<unk>  is ongoing. Anti-PAF drugs Anti-PAF drugs are currently being used in cardiac rehabilitation trials. Anti-PAF drugs are used to block angiotensin II type 1 receptors to lower in the risk of atrial fibrillation in individuals with paroxysmal fibrillation. It is also used to lessen the effects of allergies.
Platelet-activating factor
Thrombin
Von Willebrand factor
Prothrombinase
Factor VIII 
Factor VIII
Kallikrein
Fibrinogen