During normal embryologic development, hematopoiesis can occur in the dermis until the fifth month of gestation.<unk><unk>  lesions in the neonate indicate the prolongation of dermal extramedullary hematopoiesis outside of the gestational period. The<unk><unk>  rash was originally considered pathognomonic of congenital rubella, but it is now considered to be potentially associated with many other intrauterine infections, hematologic diseases, and malignancies. Other TORCH infections that can cause this rash include cytomegalovirus, herpes virus, and toxoplasma. Blood disorders, such as hereditary spherocytosis and hemolytic disease of the newborn, that increase extramedullary hemotopoeisis can also cause a<unk> . It is also possible that a neonate with the<unk><unk>  rash can have an underlying malignancy such as metastatic neuroblastoma and congenital leukemia. Listed below are a few known conditions that can cause a<unk> . Infectious * Toxoplasmosis: TORCH infection due to Toxoplasma gondii parasite. Condition is commonly associated with undercooked meat or contact with cat feces. Symptoms of this disease include seizures, hydrocephalus, and chorioretinitis. * Cytomegalovirus: viral TORCH infection associated with sensorineural hearing loss, hepatomegaly, and jaundice. * Rubella: viral TORCH infection associated with post-auricular and occipital lymphadenopathy in addition to a maculopapular rash that starts on the face and spreads to the trunk. * Herpes virus: viral TORCH infection associated with painful vesicular lesions and meningitis. * Syphilis: bacterial TORCH infection due to Treponema pallidum. Congenital syphilis can present with saber shins, saddle-shaped nose, Hutchinson's teeth, and deafness. * Epstein Barr virus: viral infection that causes infectious monocleosis. Condition is associated with lymphadenopathy, splenomegaly, and various lymphomas Hematologic * Hereditary spherocytosis: autosomal dominant disease that results in formation of aberrant erythrocyte membrane protein. This condition results in structural change of red blood cells (RBCs), shearing of RBCs, and anemia. * Hemolytic disease of the newborn (ABO or Rh incompatibility): Condition is due to maternal and fetal red blood cell mismatch. Maternal antibodies destroy fetal RBCs which results in anemia. Neoplastic * Neuroblastoma: pediatric cancer due to malignancy in neuroblast cells. Tumor is usually localized to the adrenal glands. * Congenital leukemia: pediatric cancer due to malignancy of white blood cells. * Congenital rhabdomyosarcoma: pediatric cancer due to malignancy of muscle cells. Systemic * Langerhans cell histocytosis (LCH): Condition due to excess build-up of Langerhans cells. * Lupus: autoimmune disease
Blueberry muffin baby
Lotus birth
Vanishing twin
Subcutaneous fat necrosis of the newborn
Tetter
Blue baby syndrome
Chordee
Charley horse