The lysosomal<unk><unk>  enzyme is found within the compartments of the lysosomes with in the cell. When the lysosomal<unk><unk>  enzyme is functioning properly, fats such as triglycerides and cholesteryl esters are broken down into their simpler lipid components through hydrolysis. After triglycerides are broken down, the fatty<unk> s are used for energy. Cholesteryl esters are broken down into its cholesterol and fatty<unk>  components, this delivers cholesterol to the cell. These lipids are either used by the body or sent to the liver for removal. In<unk>  the lysosomal<unk><unk>  enzyme is either lacking or missing. In both CESD and Wolman's<unk>  there is a mutation with in the LIPA gene, which maps to chromosome 10q23.2, has 10 exons and is approximately 45 kb in length, that encodes for the lysosomal<unk><unk>  enzyme. This mutation causes a loss of function in the gene. This results in the toxic buildup of fats in the body's cells and tissues, which causes an array of symptoms.
Acid lipase disease
Glycogen storage disease type 0
Intestinal metabolic bromhidrosis syndrome
Gluten-sensitive enteropathy–associated conditions
Inborn errors of carbohydrate metabolism
Lipoprotein lipase deficiency
Glycogen storage disease type IX
Glycogen storage disease type VI