Absolute bioavailability of<unk>  is about 20% and Cmax is reached in 3 to 5 hours; administration with food did not affect the AUC according to the original sponsor submitted clinical study and as per product label. However, a subsequent clinical study has shown a marked reduction in<unk>  exposure when administered with food. It is 88% protein bound, mainly to albumin. Fraction absorbed of<unk>  is frequently misquoted in the literature as approximately 0.5 (50%) due to a miscalculated hepatic extraction ratio in the original submission package subsequently corrected by the FDA reviewer. It is likely that closer to 0.25 (25%) of the administered dose is absorbed.<unk>  is metabolized mainly by CYP2C9 and not extensively metabolized; approximately 10% is recovered as metabolite N-desmethyl<unk> . It is excreted in feces (90%) primarily and the elimination half-life is approximately 19 hours.
Rosuvastatin
Lovastatin
Atorvastatin
Clofibrate
Pravastatin
Fluvastatin
Fenofibrate
Simvastatin