Skeletal formulae of isolated<unk> s The<unk> s are a family of sesquiterpenes with antitumor antibiotic properties produced by some mushrooms. In their isolated form,<unk> s show selective toxicity for myelocytic leukemia and other carcinoma cells.<unk> s are highly toxic, with little apparent therapeutic value in their natural form.<unk> s are thought to be responsible for the toxicity of various Omphalotus species such as O. olearius and O.<unk> s (Jack o' Lantern mushrooms), and O. nidiformis (Australian ghost fungus). Active metabolites of<unk> s damage DNA via an unknown mechanism. In addition, genetic analysis suggests that the<unk> -mediated DNA damage is ignored by global excision repair systems unless the lesions occur within stalled replication or transcription complexes.
Illudin
Somatrem
Somatrogon
Bryostatin
Mandrin 
Thiotepa
Presepsin
Metreleptin