Systemic use Very common (>10% frequency): * Headache * Hypertriglyceridemia * High density lipoprotein decreased * Hypercholesterolemia Common (1-10% frequency): * Anaemia * Increased iron binding capacity * Monocytes decreased * Thrombocytes increased * TSH decreased * Free T4 decreased * Flushing * Conjunctivitis * Dry eye * Eye irritation * Transaminase increased * Dry skin * Dry lips * Cheilitis * Eczema * Dermatitis * Erythema * Hair loss * Joint pain * Muscle pains * Blood creatine phosphokinase increased Uncommon (0.1-1% frequency): * Blurred vision * Cataracts * Nose bleeds * Itchiness * Rash * Skin exfoliation * Asteatotic eczema * Exostosis * Ankylosing spondylitis Rare (10% frequency): * Rash (77%) * Pain (34%) * Itchiness (11%) Common (1-10% frequency): * Exfoliative dermatitis * Oedema * Skin changes * Paraesthesia Contraindications Pregnancy is an absolute contraindication as with most other vitamin A products, it should also be avoided when it comes to systemic use in any women that is of childbearing potential and not taking precautions to prevent pregnancy. Toctino (the oral capsule formulation of<unk>  contains soya oil and sorbitol. Patients who are allergic to peanut, soya or with rare hereditary fructose intolerance should not take this medicine. It is also contraindicated in nursing mothers. The oral formulation of<unk>  is contraindicated in patients with: * Hepatic insufficiency * Severe chronic kidney disease * Uncontrolled hypercholesterolemia * Uncontrolled hypertriglyceridemia * Uncontrolled hypothyroidism * Hypervitaminosis A * Hypersensitivity to any excipients in<unk>  Interactions It is a CYP3A4 substrate and hence any inhibitor or inducer of this enzyme may alter plasma levels of<unk> . It should not be given to patients with excess vitamin A in their system as there is a potential for its actions on the retinoid X receptor to be exacerbated. It may also interact with tetracyclines to cause benign intracranial hypertension. Overdose<unk>  is a form of vitamin A.<unk>  has been administered in oncological clinical studies at dosages of more than 10-times of the therapeutic dosage given for chronic hand eczema. The adverse effects observed were consistent with retinoid toxicity, and included severe headache, diarrhoea, facial flushing and hypertriglyceridemia. These effects were reversible.
Alitretinoin
Tretinoin
Isotretinoin
Clobetasol
Clobetasol propionate
Ulobetasol propionate
Urodilatin
Cortistatin 