Lip pits may be surgically removed either for aesthetic reasons or discomfort due to inflammation caused by bacterial infections or chronic saliva excretion, though spontaneous shrinkage of the lip pits has occurred in some rare cases. Chronic inflammation has also been reported to cause squamous-cell carcinoma. It is essential to completely remove the entire lip pit canal, as mucoid cysts can develop if mucous glands are not removed. A possible side effect of removing the lip pits is a loose lip muscle. Other conditions associated with<unk> , including CL, CP, congenital heart defects, etc. are surgically corrected or otherwise treated as they would be if they were non-syndromic.
Van der Woude syndrome
Helsmoortel-Van der Aa syndrome
Van Den Bosch syndrome
Koolen–De Vries syndrome
Van Wyk and Grumbach syndrome
Wildervanck syndrome
Van Gogh syndrome
Nezelof syndrome