The disease is characterized by flesh-colored to erythematous (reddened) papules occurring in the central region of the face and sometimes elsewhere on the body, often accompanied by protrusive "spicules" or spines made of keratin and by alopecia of affected skin, typically the eyebrows and sometimes the eyelashes or scalp hairs. Pruritus (itching) has been described in about a third of reported cases. Facial papules are generally 1- to 3-mm in size. The condition is considered to be benign, but can be disfiguring; the spines are often prominent, and in later stages the affected facial skin thickens noticeably.
Trichodysplasia spinulosa
Adiposogenital dystrophy
Encephalocraniocutaneous lipomatosis
Pachyonychia congenita
Lipoatrophia annularis
Mandibuloacral dysplasia
Thanatophoric dysplasia
Genu recurvatum