<unk>  (also known as<unk> 's disease and multiple hamartoma<unk>  is an autosomal dominant inherited condition characterized by benign overgrowths called hamartomas as well as an increased lifetime risk of breast, thyroid, uterine, and other cancers. It is often underdiagnosed due to variability in disease presentation, but 99% of patients report mucocutaneous symptoms by age 20-29. Despite some considering it a primarily dermatologic condition,<unk> 's<unk>  is a multi-system disorder that also includes neurodevelopmental disorders such as macrocephaly. The incidence of<unk> 's disease is about 1 in 200,000, making it quite rare. Furthermore, early and continuous screening is essential in the management of this disorder to prevent malignancies. It is associated with mutations in PTEN on 10q23.3, a tumor suppressor gene otherwise known as phosphatase and tensin homolog, that results in dysregulation of the mTOR pathway leading to errors in cell proliferation, cell cycling, and apoptosis. The most common malignancies associated with the<unk>  are adenocarcinoma of the breast (20%), followed by adenocarcinoma of the thyroid (7%), squamous cell carcinomas of the skin (4%), and the remaining from the colon, uterus, or others (1%).
Cowden syndrome
Juvenile polyp
Laron syndrome
Fox–Fordyce disease
Jervell and Lange-Nielsen syndrome
Danon disease
Pott disease
Scott syndrome