Active<unk>  works as an initiating<unk>  by cleaving, thus activating downstream executioner<unk> s, initiating apoptosis. Once activated,<unk>  goes on to cleave<unk> , -6, and -7, initiating the<unk>  cascade as they cleave several other cellular targets. When<unk>  is inactive, it exists in the cytosol as a zymogen, in its monomer form. It is then recruited and activated by the CARDs in apaf-1, recognizing the CARDs in<unk> . Processing Before activation can occur,<unk>  has to be processed. Initially,<unk>  is made as an inactive single-chain zymogen. Processing occurs when the apoptosome binds to pro-caspase-9 as apaf-1 assists in the autoproteolytic processing of the zymogen. The processed<unk>  stays bound to the apoptosome complex, forming a holoenzyme. Activation Activation occurs when<unk>  dimerizes, and there are two different ways for which this can occur: #<unk>  is auto-activated when it binds to apaf-1(apoptosome), as apaf-1 oligomerizes the precursor molecules of pro-caspase-9. # Previously activated<unk> s can cleave<unk> , causing its dimerization. Catalytic activity<unk>  has a preferred cleavage sequence of Leu-Gly-His-Asp-(cut)-X.
Caspase-9
STAT protein
NLRP3
Bcl-xL
Zinc transporter 8
Fc receptor
IKK2
Thromboxane receptor