Cancer treatment<unk> s can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor growth. Because cancer cells spend more time dividing than other cells, inhibiting cell division harms tumor cells more than other cells.<unk>  drugs are commonly used to treat leukemia, cancers of the breast, ovary, and the gastrointestinal tract, as well as other types of cancers. In the Anatomical Therapeutic Chemical Classification System<unk>  cancer drugs are classified under L01B.<unk> s generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation. Examples of cancer drug<unk> s include, but are not limited to the following: *5-Fluorouracil (5-FU) *6-Mercaptopurine (6-MP) *Capecitabine (Xeloda®) *Cytarabine (Ara-C®) *Floxuridine *Fludarabine *Gemcitabine (Gemzar®) *Hydroxycarbamide *Methotrexate *Pemetrexed (Alimta®) *Phototrexate<unk> s masquerade as a purine (azathioprine, mercaptopurine) or a pyrimidine, chemicals that become the building-blocks of DNA. They prevent these substances from becoming incorporated into DNA during the S phase (of the cell cycle), stopping normal development and cell division.<unk> s also affect RNA synthesis. However, because thymidine is used in DNA but not in RNA (where uracil is used instead), inhibition of thymidine synthesis via thymidylate synthase selectively inhibits DNA synthesis over RNA synthesis. Due to their efficiency, these drugs are the most widely used cytostatics. Competition for the binding sites of enzymes that participate in essential biosynthetic processes and subsequent incorporation of these biomolecules into nucleic acids, inhibits their normal tumor cell function and triggers apoptosis, the cell death process. Because of this mode of action, most<unk> s have high cell cycle specificity and can target arrest of cancer cell DNA replication. Antibiotics<unk> s may also be antibiotics, such as sulfanilamide drugs, which inhibit dihydrofolate synthesis in bacteria by competing with para-aminobenzoic acid (PABA). PABA is needed in enzymatic reactions that produce folic acid, which acts as a coenzyme in the synthesis of purines and pyrimidines, the building-blocks of DNA. Mammals do not synthesize their own folic acid so they are unaffected by PABA inhibitors, which selectively kill bacteria. Sulfanilamide drugs are not like the antibiotics used to treat infections. Instead, they work by changing the DNA inside cancer cells to keep them from growing and multiplying. Antitumor antibiotics are a class of<unk>  drugs that are cell cycle nonspecific. They act by binding with DNA molecules and preventing RNA (ribonucleic acid) synthesis, a key step in the creation of proteins, which are necessary for cancer cell survival. Anthracyclines are anti-tumor antibiotics that interfere with enzymes involved in copying DNA during the cell cycle. Examples of anthracyclines include: *Daunorubicin *Doxorubicin (Adriamycin®) *Epirubicin *Idarubicin Anti-tumor antibiotics that are not anthracyclines include: *Actinomycin-D *Bleomycin *Mitomycin-C *Mitoxantrone *Phototrexate Other uses<unk> s, particularly mitomycin C (MMC), are commonly used in America and Japan as an addition to trabeculectomy, a surgical procedure to treat glaucoma.<unk> s have been shown to decrease fibrosis of operative sites. Thus, its use following external dacryocystorhinostomy, a procedure for the management of nasolacrimal duct obstruction, is being researched. Intraoperative<unk>  application, namely mitomycin C (MMC) and 5-fluorouracil (5-FU), is currently being tested for its effectiveness of managing pterygium.
Antimetabolite
Toxicophore
Topoisomerase inhibitor
Immunoconjugate
Monoclonal antibody
Antioxidant
Antiparasitic
Antiviral drug