The features associated with this condition include: mild to moderate learning difficulties, short stature, unique facial features, small head and skeletal abnormalities including bony growths projecting from the surfaces of bones. Craniofacial Individuals with<unk>  may display characteristic craniofacial abnormalities. These include a long prominent philtrum, a thin upper lip, wide spaced eyes, a bulbous nasal tip, a broad nasal bridge, wide nostrils, micrognathia, retrognathia, deep set eyes and large ears. The head itself is often unusually small in comparison to that of unaffected individuals of the same age and sex. Dental abnormalities, such as supernumerary central incisors and the absence of some teeth, may occur Muscoskeletal image:Langer-Giedion_syndromeFeet.The right foot of a person with<unk>  showing the characteristic features Image:Langer-Giedion syndromeHands.Hands of a person with<unk>  showing the characteristic short fingers<unk>  causes cone shaped epiphyses of the phalanges of the hands and short fingers and toes. The fifth fingers are sometimes bent. Skeletal abnormalities not effecting the hands and feet may also occur. These include winged scapula, thin ribs and scoliosis. In addition, individuals with<unk>  may develop hip problems similar to those seen in Legg–Calvé–Perthes disease such as progressive degeneration of the head of the thigh bone. As effected individuals age they often develop benign boney growths called exostoses which project off the surfaces of the bones. Depending on the location of the exostoses they cause numerous complications such as compression of the spinal cord, asymmetric growth of the limbs and reduced mobility.<unk>  initially causes joint hypermobility. This progresses to joint stiffness later in life when osteochondromas begin to develop, typically between infancy and mid-childhood, which decreases mobility. Hip dysplasia may be present, usually developing in early adulthood although it can occur in infancy or childhood. Skin, hair, sweat glands and nails Ectodermal dysplasia is a key feature of<unk> . The majority of individuals with<unk>  have sparse scalp hair; this is particularly severe in males, who often experience alopecia shortly after puberty. Despite this the eyebrows may be unusually thick.
Langer–Giedion syndrome
Legg–Calvé–Perthes disease
Bardet–Biedl syndrome
Fibrodysplasia ossificans progressiva
Daentl Townsend Siegel syndrome
Tricho-rhino-phalangeal syndrome Type 1
Schinzel–Giedion syndrome
Marshall–Smith syndrome