Diamorphine is produced from acetylation of morphine derived from natural opium sources, generally using acetic anhydride. The major metabolites of diamorphine, 6-MAM, morphine, morphine-3-glucuronide, and morphine-6-glucuronide, may be quantitated in blood, plasma or urine to monitor for use, confirm a diagnosis of poisoning, or assist in a medicolegal death investigation. Most commercial opiate screening tests cross-react appreciably with these metabolites, as well as with other biotransformation products likely to be present following usage of street-grade diamorphine such as 6-acetylcholine and codeine.<unk> owever, chromatographic techniques can easily distinguish and measure each of these substances. When interpreting the results of a test, it is important to consider the diamorphine usage<unk> istory of the individual, since a chronic user can develop tolerance to doses that would incapacitate an opiate-naive individual, and the chronic user often<unk> as<unk> igh baseline values of these metabolites in<unk> is system. Furthermore, some testing procedures employ a<unk> ydrolysis step before quantitation that converts many of the metabolic products to morphine, yielding a result that may be 2 times larger than with a method that examines each product individually.
Heroin
Cannabis
Cannabis 
Cocaine
Cocaine 
Nicotine
Phencyclidine
Opioid