In human, the SRY gene is located on short (p) arm of the Y chromosome at position 11.2<unk>  <unk> , also known as sex-determining region Y (SRY) protein, is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placental mammals and marsupials). SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development (DSD) with varying effects on an individual's phenotype and genotype.<unk>  is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. When complexed with the SF1 protein,<unk>  acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a<unk> . The now-induced Leydig cells of the<unk>  then start secreting<unk> terone, while the Sertoli cells produce anti-Müllerian hormone. SRY gene effects normally take place 6–8 weeks after fetus formation which inhibits the female anatomical structural growth in males. It also works towards developing the dominant male characteristics.
Testis-determining factor
Cenegermin
Androgen-binding protein
Core binding factor
Androgen prohormone
Dieldrin
Keratinocyte growth factor
Transfer factor