Infections leading to<unk>  are usually bacterial but may be fungal, parasitic or viral. Gram-positive bacteria were the primary cause of<unk>  before the introduction of antibiotics in the 1950s. After the introduction of antibiotics, gram-negative bacteria became the predominant cause of<unk>  from the 1960s to the 1980s. After the 1980s, gram-positive bacteria, most commonly staphylococci, are thought to cause more than 50% of cases of<unk> . Other commonly implicated bacteria include Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella species. Fungal<unk>  accounts for approximately 5% of severe<unk>  and septic shock cases; the most common cause of fungal<unk>  is an infection by Candida species of yeast, a frequent hospital-acquired infection. The most common causes for parasitic<unk>  are Plasmodium (which leads to malaria), Schistosoma and Echinococcus. The most common sites of infection resulting in severe<unk>  are the lungs, the abdomen, and the urinary tract. Typically, 50% of all<unk>  cases start as an infection in the lungs. In one-third to one-half of cases, the source of infection is unclear.
Sepsis
Capillary leak syndrome
Tumor lysis syndrome
Malignant hyperthermia
Septic shock
Necrotizing enterocolitis
Asepsis
Salicylate poisoning