An<unk>  (AOP) is structured representation of biological events leading to<unk>  effects and is considered relevant to risk assessment. The AOP links in a linear way existing knowledge along one or more series of causally connected key events (KE) between two points — a molecular initiating event (MIE) and an<unk>  outcome (AO) that occur at a level of biological organization relevant to risk assessment. The linkage between the events is described by key event relationships (KER) that describe the causal relationships between the key events. AOPs are important for expanding the use of mechanistic toxicological data for risk assessment and regulatory applications with recent applications in further disciplines such as climate science. Schematic representation of AOP with hypothetical events
Adverse outcome pathway
Clinical trial naming conventions
Appropriate use criteria
Scientific consensus
Operational Research CONsultancy
Sentinel event
Outcome measure
Exposure hierarchy