<unk>  has potentially serious adverse effects, and at least five deaths had been reported due to the<unk> 's use on people with cancer. From 1975 to 1983 in Germany, research revealed six deaths, four cases of visual disturbance, three cases of paraplegias, four gas embolisms in the pulmonary circuit, two heart attacks, four pulmonary embolisms, two cases of apoplectic paralysis, and two cases of abnormal heart rhythm following<unk> . More commonly, pulmonary edema is the most prevalent adverse effect of<unk>  treatment. In the muscular system, many cases of tendon rupture, osteoarthritis, myositis, synovitis, joint infections, and muscle tears have been documented results of<unk> . In the integumentary system, benign skin discoloration is most common. These all occurred following direct injection of O2/O3 gas: a method now regarded as malpractice by most<unk>  practitioners. In each case, the clinical picture corresponded either to gas embolism, or allergic shock. The fact that one case of apparent allergic shock followed injection of a very small quantity of gas raises the unknown possibility that other methods of administration might also carry the risk of allergic shock. Much of the concern related to<unk>  revolves around the safety of blood<unk> tion. When inhaled by mammals in high levels,<unk>  reacts with compounds in tissues lining the lungs and triggers a cascade of pathological effects, including pulmonary edema, however,<unk>  does not usually involve inhalation of<unk>  gas. It has been argued that while peroxides (a product of<unk>  are naturally generated inside phagocyte cells to kill bacteria, outside the cell they can damage tissue. Proponents suggest that its effects are tissue dependent, though the subject is still debated. Other serious incidents reported include transmission of hepatitis C, and one case of a heart attack following some hours after autohemotherapy. However, this last article was widely discussed and criticized by other authors.<unk> -based treatments can be associated with central nervous system toxicity, termed<unk>  Induced Encephalopathy (OIE). OIE may include cortical visual impairment, altered mental status, headache, focal neurological deficits, seizures, dizziness, nausea, and vomiting, regardless of the route of administration. OIE should be considered in patients presenting with neurological symptoms in close relation to<unk> .
Ozone therapy
Maggot therapy
Ultraviolet light therapy
Narrative exposure therapy
Topical steroid withdrawal
Particle therapy
Allergen immunotherapy
Asthma spacer