<unk>  can also be classified based on the presence or absence of systemic symptoms.<unk>  without systemic disease can be a result of trauma or cold.<unk>  with systemic disease can be caused by: * connective tissue disorders such as lupus erythematosus or scleroderma; * lymphoproliferative disease such as lymphoma or histiocytosis; * pancreatitis or pancreatic cancer; * sarcoidosis with cutaneous involvement (seen in up to 20 percent); * Alpha 1-antitrypsin deficiency * Crohn's disease This is not a complete list of possible causes. Associated conditions Lipoatrophy or lipodystrophy (the loss of subcutaneous adipose tissue) can occur in any of these conditions.
Panniculitis
Dactylitis
Trombiculosis
Cheilitis
Coxalgia
Palindromic rheumatism
Arthus reaction
Ankle flare