For type A and B, levels of sphingomylinase can be measured from a blood sample. To diagnose type C, a skin sample can help determine whether the transporter is affected via the Filipin test which detects build-up of unesterified cholesterol via fluorescent staining. Classification There are four types of<unk>  in two categories. Patients with ASM deficiency are classified into type A and B. Type A patients exhibit hepatosplenomegaly in infancy and profound central nervous system involvement and unable to survive beyond two years of age. Type B patients also show hepatosplenomegaly and pathologic alterations of their lungs but usually without the involvement of their central nervous system. Some can develop significant life-threatening complications including liver failure, hemorrhage, oxygen dependency, pulmonary infections, and splenic rupture. Some develop coronary artery or valvular heart disease. In a longitudinal natural history study, nearly 20% of the patients died. For those classified into type C, they may have mild hepatosplenomegaly, but their central nervous system is profoundly affected. *<unk> , SMPD1-associated, which includes types A and B :*<unk>  type A: classic infantile :*<unk>  type B: visceral *<unk> , type C: subacute/juvenile, includes types C1 (95% of type C) and C2. Type C is the most common form of the disease Type C2 is a rare form of the disease.<unk>  type D (or Nova Scotia form) is now believed to be the same condition as<unk>  type C. Two poorly characterized forms of<unk>  have also been described as types E and F.
Niemann–Pick disease
Wilson's disease
Wilson–Mikity syndrome
Haemochromatosis type 3
Mowat–Wilson syndrome
Hemochromatosis type 4
Gaucher's disease
Maroteaux–Lamy syndrome