The peptide HLTx consists of 242 amino acids residues in a single polypeptide chain. It is stabilized with eight disulfide bridges and has a molecular weight of 25.5 kDa. The iso-electric point is 6.8 and the N-terminal amino acid sequence is: Glu-Ala-Ser-Pro-Lys-Leu-Pro-Gly-Leu-Met-Thr-Ser-Asn-Pro-Asp-Gln-Gln-Thr- Glu-Ile. HLTx shows no structural similarities with any of the known sodium-, potassium- or calcium channel-specific toxins. Highest similarities are found with a family of cysteine-rich secretory proteins (CRISP), found in human and in mice testes.
Helothermine
Amylmetacresol
Tetrachlorodecaoxide
Phenylsilatrane
Dichloroacetic acid
Silver diammine fluoride
Photoanethole
Silver nitrate