Ataxia with telangiectasia is a rare form ataxia that causes chromosomal instability, sensitivity to ionizing radiation, disrupted stress-activated signal transduction pathways and radioresistant DNA synthesis. The genes that underlie majority of the symptoms for the different types of ataxia are still unknown. A productive cure is still unavailable to prevent the brain degeneration associated with ataxia. Oculomotor ataxia accompanies gait ataxia which causes dysarthria, muscle weakness, loss of joint position sense and limb dysmetria. In some cases, patients have shown mental retardation and loss of myelinated axons.
Autosomal recessive cerebellar ataxia type 1
Autosomal recessive spastic ataxia of Charlevoix-Saguenay
Autosomal dominant cerebellar ataxia
Spinocerebellar ataxia type 6
Spinal muscular atrophy with lower extremity predominance 1
Benign hereditary chorea
Madras motor neuron disease
Spinocerebellar ataxia type 1