<unk>  has a fairly rapid first-pass metabolism in the liver. Its major metabolites include an inactive metabolite, N-desmethylclarithromycin, and an active metabolite, 14-(R)-hydroxyclarithromycin. Compared to<unk> , 14-(R)-hydroxyclarithromycin is less potent against mycobacterial tuberculosis and the Mycobacterium avium complex.<unk>  (20%-40%) and its active metabolite (10%-15%) are excreted in urine. Of all the drugs in its<unk> ss,<unk>  has the best bioavailability at 50%, which makes it amenable to oral administration. Its elimination half-life is about 3 to 4 hours with 250 mg administered every 12 h, but increased to 5 to 7 h with 500 mg administered every 8 to 12 h. With any of these dosing regimens, the steady-state concentration of this metabolite is generally attained within 3 to 4 days.
Clarithromycin
Erythromycin
Cethromycin
Natamycin
Paromomycin
Clindamycin
Meropenem
Anisomycin