The protein encoded by this gene is the<unk>  component of<unk> , a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide<unk> s. Following vascular injury,<unk>  is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. In addition, various cleavage products of<unk>  and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia,<unk> emia, and renal amyloidosis. Alternative splicing results in two isoforms that vary in the carboxy-terminus.
Fibrinogen alpha chain
Von Willebrand factor
Fibrinogen gamma chain
Fibrinogen beta chain
Fibrin monomer
Glycoprotein IX
Β-Thromboglobulin
Factor VIII 