<unk> s (PAMORAs) are a class of chemical compounds that are used to reverse adverse effects caused by<unk> s interacting with receptors outside the central nervous system (CNS), mainly those located in the gastrointestinal tract. PAMORAs are designed to specifically inhibit certain<unk>  receptors in the gastrointestinal tract and with limited ability to cross the blood-brain barrier. Therefore, PAMORAs do not affect the analgesic effects of<unk> s within the central nervous system.
Peripherally acting μ-opioid receptor antagonist
Serotonin–dopamine releasing agent
Serotonin receptor agonist
Norepinephrine–dopamine releasing agent
Serotonin–norepinephrine–dopamine releasing agent
Long-acting beta-adrenoceptor agonist
Noradrenergic and specific serotonergic antidepressant
Serotonin–norepinephrine releasing agent