Cytoreductive "debulking" surgery may be performed prior to chemotherapy treatment in order to decrease the physical mass of the tumour and thus reduce the number of chemotherapy cycles needed. The typical advanced presentation as well as extra-ovarian spread seen in HGSC can require aggressive debulking procedures. In some cases total abdominal hysterectomy will be performed, in other cases where the patient intends to bear children a salpingo-oophorectomy is performed instead. Typical chemotherapy is six cycles of intraperitoneally-delivered platinum-base adjuvant chemotherapy with agents such as carboplatin. Measurements of blood CA125 levels are used to determine patient response to the treatment. Between 20% and 30% of patients relapse within six months of treatment. Poly ADP ribose polymerase (PARP) inhibitors are another possible treatment, with carriers of BRCA1/2 mutations being the most responsive
High-grade serous carcinoma
Endometrial stromal sarcoma
Adenomyomatosis
Uterine clear-cell carcinoma
Endometrial stromal tumour
Tubular carcinoma
Uterine serous carcinoma
Papillary serous cystadenocarcinoma