*Potential role of genetic markers in the identification of persons at risk. There is a 75% probability to identify the two ENPP1 mutations or 10% with ABCC6 mutations (one paternal, one maternal) that cause GACI. Once the mutations are identified, preimplantation genetic diagnosis (PGD) or chorionic villus sampling (CVS) are possible options to identify the condition, either before or during pregnancy. *At week 20 of gestation, it is possible to detect an Echogenic intracardiac focus (EIF) or intravascular<unk> s, particularly in the iliac and abdominal aorta. EIF is a small bright spot seen in the baby’s heart on an ultrasound exam. This is thought to represent mineralization, or small deposits of calcium hydroxyapatite, in the muscle of the heart. EIFs are found in about 3-5% of normal pregnancies and cause no health problems. *Ultrasound can show subtle intravascular<unk> s, particularly in the abdominal aorta at week 23.<unk>  has been detected at 33 weeks' gestation. *The earliest detected manifestation (echogenic foci in the mitral valve Hepatic vascular) of the disease was prenatally at 14 weeks gestation.
Generalized arterial calcification of infancy
Primary familial brain calcification
Hypertension and brachydactyly syndrome
Multifocal fibrosclerosis
Calcinosis cutis
Lipodermatosclerosis
Normolipoproteinemic xanthomatosis
Universal angiomatosis