Treatment in<unk>  focuses on preventing and treating infections. Broad-spectrum antibiotics are a common mode of treatment when infection is present, though some infections (like lung abscesses) require surgical treatment. Pneumatocele may be treated with surgery, but the benefit is unclear. Surgical treatment is also recommended for skin abscesses, along with topical and systemic antibiotics and antifungals. Long-term treatment with systemic antibiotics, including trimethoprim/sulfamethoxazole, penicillins, and cephalosporins, is effective in preventing skin and lung infections. Other treatments used in<unk>  include sodium cromoglycate, which improves white blood cell function, and isotretinoin, which improves skin condition. Sometimes, Intravenous immunoglobulin is used as a treatment, but its benefits have not been proven. Levamisole is also ineffective. Mixed clinical outcomes have been found with interferon gamma and omalizumab. Though early research on hematopoietic stem cell transplantation was equivocal, later research has shown it to improve immune function. Two patients have been cured by bone marrow transplantation. Cyclosporine A is a current topic of research; preliminary results have shown it to be effective.
DOCK8 deficiency
ZAP70 deficiency
PMM2 deficiency
WNT4 deficiency
ZC4H2 deficiency
NGLY1 deficiency
Janus kinase 3 deficiency
MECP2 duplication syndrome