Increases in<unk> l curvature are thought to be caused by<unk> l thinning-induced ectasia. Two explanations have been proposed for contact<unk> -induced stromal thinning. It is thought that contact<unk> -induced edema may inhibit stroma tissue synthesis. Alternatively, contact<unk> -induced hypoxia may trigger a lactic acid buildup that leads to the erosion of stromal tissue. The mechanism behind contact<unk> -induced polymegethism is unknown, though it is also thought to be a byproduct of<unk> l edema and epithelial hypoxia. It is thought that constant adhesion of contact<unk> es to the<unk>  may lead to adaptation to mechanical stimuli, thus decreasing<unk> l sensitivity to tactile stimuli. A proposed explanation for the reduced sensitivity is the induced quiescence of free nerve endings following<unk> <unk><unk> l exposure to contact<unk> es.
Effects of long-term contact lens wear on the cornea
Recurrent corneal erosion
Pachychoroid disorders of the macula
Chronic relapsing inflammatory optic neuropathy
Fungal contamination of contact lenses
Recurrent painful ophthalmoplegic neuropathy
Peripheral ulcerative keratitis
Late congenital syphilitic oculopathy