Research tool Due to its high proteolytic specificity,<unk>  is a valuable biochemical tool.<unk> e<unk>  cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is commonly included in linker regions of recombinant fusion protein constructs. Following purification of<unk> e fusion protein,<unk>  can be used to selectively cleave between<unk> e arginine and glycine residues of<unk> e cleavage site, effectively removing<unk> e purification tag from<unk> e protein of interest with a high degree of specificity. Medicine and surgery Prothrombin complex concentrate and fresh frozen plasma are prothrombin-rich coagulation factor preparations<unk> at can be used to correct deficiencies (usually due to medication) of prothrombin. Indications include intractable bleeding due to warfarin. Manipulation of prothrombin is central to<unk> e mode of action of most anticoagulants. Warfarin and related drugs inhibit vitamin K-dependent carboxylation of several coagulation factors, including prothrombin. Heparin increases<unk> e affinity of antithrombin to<unk>  (as well as factor Xa).<unk> e direct<unk>  inhibitors, a newer class of medication, directly inhibit<unk>  by binding to its active site. Recombinant<unk>  is available as a powder for reconstitution into aqueous solution. It can be applied topically during surgery, as an aid to hemostasis. It can be useful for controlling minor bleeding from capillaries and small venules, but ineffective and not indicated for massive or brisk arterial bleeding. Food production<unk> , combined with fibrinogen, is sold under<unk> e brand name Fibrimex for use as a binding agent for meat. Both proteins in Fibrimex derives from porcine or bovine blood. According to<unk> e manufacturer it can be used to produce new kinds of mixed meats (for example combining beef and fish seamlessly).<unk> e manufacturer also states<unk> at it can be used to combine whole muscle meat, form and portion<unk> ese,<unk> us cutting down on production costs without a loss in quality. General secretary Jan Bertoft of Swedish Consumers' Association has stated<unk> at "there is danger of misleading<unk> e consumers since<unk> ere is no way to tell<unk> is reconstituted meat from real meat".
Thrombin
Prothrombinase
Platelet-activating factor
Kallikrein
Plasminogen 
Fibrinolysin
Von Willebrand factor
Serpin