<unk>  replicates in the mosquito's midgut epithelial cells and then its salivary gland cells. After 5–10 days, the virus can be found in the mosquito's saliva. If the mosquito's saliva is inoculated into human skin, the virus can infect epidermal keratinocytes, skin fibroblasts in the skin and the Langerhans cells. The pathogenesis of the virus is hypothesized to continue with a spread to lymph nodes and the bloodstream. Flaviviruses replicate in the cytoplasm, but<unk>  antigens have been found in infected cell nuclei. The viral protein numbered NS4A can lead to small head size (microcephaly) because it disrupts brain growth by hijacking a pathway which regulates growth of new neurons. In fruit flies, both NS4A and the neighboring NS4B restrict eye growth.
Zika virus
West Nile virus
Sepik virus
Western equine encephalitis virus
Venezuelan equine encephalitis virus
Dengue virus
Muju virus
Rabies virus