St John's wort may cause allergic reactions and can interact in dangerous, sometimes life-threatening ways with a variety of prescribed medicines. St John's wort is generally well tolerated, but it may cause gastrointestinal discomfort (such as nausea, abdominal pain, loss of appetite, and diarrhea), dizziness, confusion, fatigue, sedation, dry mouth, restlessness, and headache. The organ systems associated with adverse drug reactions to St John's wort and fluoxetine (an SSRI) have a similar incidence profile; most of these reactions involve the central nervous system. St John's wort also decreases levels of estrogens, such as estradiol, by accelerating its metabolism, and women on contraceptive pills are not advised to take it. St John's wort may cause photosensitivity. This can lead to visual sensitivity to visible and ultraviolet light and to sunburns in situations that would not normally cause them.
Hypericum perforatum
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