TP53 is mutated in 70 to 90% of SCLCs. RB1 and the retinoblastoma pathway are inactivated in most SCLCs. PTEN is mutated in 2 to 10%. MYC amplifications and amplification of MYC family members are found in 30% of SCLCs. Loss of heterozygocity on chromosome arm 3p is found in more than 80% of SCLCs, including the loss of FHIT. One hundred translocations have so far been reported in SCLCs (see the "Mitelman Database" and the Atlas of Genetics and Cytogenetics in Oncology and Haematology,).
types of Anal cancer
types of Bladder cancer
types of Gastrointestinal bleeding
types of Skin cancer
medical cause of Stomach cancer
medical cause of Cervical cancer
symptom of Appendix cancer
medical cause of Mucosal melanoma