The age of onset is often in puberty. Of the described cases, as high as 80% of the affected individuals was suffering from the disease prior to the age of 18. However, Latos-Bielenska et al. stated that this percentage should be lower, because also another form of osteoarthropathy – familial idiopathic osteoarthropathy (FIO) - was taken into account in this analysis.<unk>  usually progresses for 5 to 20 years, until it becomes stable. Life expectancy may be normal, despite patients getting many functional and cosmetic complications, including restricted motion, neurologic manifestations and leonine facies.
Pachydermoperiostosis
Acromegaly
Craniosynostosis
Melorheostosis
Buccal exostosis
Subungual exostosis
Achondroplasia
Pseudoachondroplasia