<unk>  has been shown to interact with TRPV5, TRPV6, TASK-1, ASIC1a, CTSB, BAD, KCNK3, UBC and ANXA2. There is a specificity in the interaction between p11 and 5-HT1B. In a two-hybrid screen using twenty six out of 29 double-positive prey clones containing the gene encoding p11. This study showed that p11 interacted with 5-HT1B receptors but not with 5-HT1A, 5-HT2A, 5-HT5A, 5-HT6, dopamine D1 or D2 receptors, two irrelevant baits (C{Delta}115 and pRP21), or the empty plasmid. The specific interaction has been verified in three other ways: In HeLa cells and brain tissue p11 was found to coimmunoprecipitate with 5-HT1B receptors; Immunofluorescence studies show colocalization between p11 and 5-HT1B receptors at the cell surface; and distribution of p11 mRNA in the brain resembles that of 5-HT1B receptor mRNA. The table below shows the proteins that interact with p11 and the functional role of p11 in these interactions Table 1 Interactor Biological function of P11 Reference Annexin 2 Regulation of endosomal functions 5-HT1B receptor Localization of 5-HT1B receptors at the cell surface NaV1.8 sodium channel Increase of NaV1.8 channels at the plasma membrane TASK-1 potassium channel Regulation of TASK-1 channels at the plasma membrane ASIC-1 channels Increase of ASIC channels at the plasma membrane TRPV5/TRPV6 channels Increase of TRPV5/TRPV6 channels at the plasma membrane NS3 Mediation of virus release Cytosolic phospholipase A2 Reduced arachidonic acid release BAD Inhibition of pro-apoptotic effect HPV16 L2 Facilitates binding and entry of human papillomavirus type 16
S100A10
OPS-301
BIM-1
LAE-32
MIN-117
RGC100
AP-7 
Myeloma protein