The<unk>  is the relationship between the biological<unk>  and the chemical structure or<unk> al changes of a biomolecule. This terminology emphasizes the importance of dynamic<unk> al changes for the biological function, rather than the importance of static three-dimensional structure used in the analysis of structure–activity relationships. The<unk> al changes usually take place during intermolecular association, such as protein–protein interaction or protein–ligand binding. A binding partner changes the<unk>  of a biomolecule (e.g. a protein) to enable or disable its biochemical<unk> . Methods for analysis of<unk>  vary from in silico or using experimental methods such as X-ray crystallography and NMR where the<unk>  before and after<unk>  can be compared statically or using dynamic methods such as multi-parametric surface plasmon resonance, dual-polarisation interferometry or circular dichroism where the kinetics as well as degree of<unk> al change can be quantified.
Conformation–activity relationship
Concept creep
Representational momentum
Gerodiversity
Cryptocurrency
Functional integration 
Therapeutic relationship
Threshold expression