Global view of a<unk>  junction:1. Axon2. Motor end-plate3. Muscle fiber4. Myofibril Detailed view of a<unk>  junction:1. Presynaptic terminal2. Sarcolemma3. Synaptic vesicle4. Nicotinic acetylcholine receptor5. Mitochondrion<unk> s block<unk>  transmission at the<unk>  junction, causing paralysis of the affected skeletal muscles. This is accomplished via their action on the post-synaptic acetylcholine (Nm) receptors. In clinical use,<unk>  block is used adjunctively to anesthesia to produce paralysis, firstly to paralyze the vocal cords, and permit intubation of the trachea, and secondly to optimize the surgical field by inhibiting spontaneous ventilation, and causing relaxation of skeletal muscles. Because the appropriate dose of<unk>  may paralyze muscles required for breathing (i.e., the diaphragm), mechanical ventilation should be available to maintain adequate respiration. Patients are still aware of pain even after full conduction block has occurred; hence, general anesthetics and/or analgesics must also be given to prevent anesthesia awareness.
Neuromuscular-blocking drug
Neuromuscular blocking agents
Cholinergic blocking drugs
Antiprion drug
Antihypotensive agent
Muscle relaxant
Immunosuppressive drug
Antihypertensive drug