Absolute contraindications, which are reasons why the procedure absolutely cannot be done, include: # Pregnancy is an absolute contraindication to the use of<unk>  irradiation. In some cases, it may be possible to perform<unk>  in the third trimester and treat the patient with radiation after delivery. # Two or more primary tumors in separate quadrants of the<unk>  or with diffuse malignant-appearing microcalcifications. # A history of prior therapeutic irradiation to the<unk>  that would require re-treatment to an excessively high total dose. # Persistent positive margins after reasonable surgical attempts: the importance of a single focally positive microscopic margin needs further study and may not be an absolute contraindication. # Inflammatory<unk>  cancer # Diffuse or indeterminate micro-calcifications on mammography Relative contraindications encompass situations of higher risk of complications to the patient that may be outweighed by other considerations, such as the benefit to the patient. Relative contraindications include: # Previous<unk>  radiation therapy # Connective tissue disease such as Scleroderma, Sjogren Syndrome, Lupus, and Rheumatoid arthritis may result in an increased risk of radiation toxicity. # Very large tumor size relative to<unk>  volume.
Breast-conserving surgery
Breast reconstruction
Preventive mastectomy
Cryoablation
Radical mastectomy
Mammaplasty
Trepanning
Microwave thermotherapy