<unk> 's<unk>  is caused by approximately 30%-50% reduced glucuronidation activity of the enzyme Uridine-diphosphate-glucuronosyltransferase isoform 1A1 (UGT1A1).  The gene which encodes UGT1A1 normally has a promoter region TATA box containing the allele A(TA6)TAA.<unk> 's<unk>  is associated with homozygous A(TA7)TAA alleles.  The allele polymorphism is referred to as UGT1A1*28.
Gilbert's syndrome pathophysiology
Alcoholic hepatitis pathophysiology
Drug induced liver injury pathophysiology
Non-alcoholic fatty liver disease pathophysiology
Galactosemia pathophysiology
Peliosis hepatis pathophysiology
Autoimmune hepatitis risk factors
Gaucher's disease risk factors