<unk><unk> , also known as Hereditary Intestinal Polyposis Syndrome, is an autosomal dominant genetic disorder caused by a mutation in the STK11 (LKB1) tumor suppressor gene. It is  characterized by the appearance of multiple benign hamartomatous polyps in the gastrointestinal tract, which increase the risk of cancer in the gastrointestinal tract.<unk>  ia also associated with hyperpigmented macules on the lips and oral mucosa (melanosis). The incidence of<unk>  is approximately 0.03 to 4 per 100,000 individuals worldwide. If left untreated, patients with<unk>  may progress to develop rectal bleeding, anemia, intussusception, bowel obstruction. Abdominal CT and MRI may help in the diagnosis of<unk><unk>  disease. Screening for intestinal and extraintestinal cancers is recommended for patients with<unk><unk>  disease. Surgery is the mainstay of treatment.
Peutz-Jeghers syndrome
Lutz-Richner and Landolt syndrome
Familial adenomatous polyposis
Ellis-van Creveld syndrome
Mounier-Kuhn syndrome
Opitz-Frias syndrome
Ataxia telangiectasia
Werner syndrome