<unk>  syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT); in a simple and useful classification method, the causes could be classified as:
Genetic causes
Accumulation of a toxic substance  (e.g. Cystinosis, Tyrosinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, Wilson, Fructose Intolerance)
Energy provision failure (e.g. Mitochondriopathies)
Disruption of endocytosis and intracellular transport mechanisms (e.g. ARC syndrome, Lowe syndrome and Dent disease).
Exogenous causes (e.g. Heavy metals exposure, Drugs, Chemotherapy)
Acquired causes (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)
Accumulation of a toxic substance  (e.g. Cystinosis, Tyrosinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, Wilson, Fructose Intolerance)
Energy provision failure (e.g. Mitochondriopathies)
Disruption of endocytosis and intracellular transport mechanisms (e.g. ARC syndrome, Lowe syndrome and Dent disease).
Fanconi syndrome causes
Noonan syndrome causes
Hurler syndrome causes
Cowden syndrome causes
Cretinism causes
Tuberous sclerosis causes
Phenylketonuria causes
Bannayan-Riley-Ruvalcaba syndrome causes