<unk>  (EDS)  is an inherited connective tissue disorder with different presentations that have been classified into several primary types. EDS is caused by a defect in the structure, production, or processing of collagen or proteins that interact with collagen, such as mutations in the COL5A or COL3A genes. (This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. Reticular fiber. Also found in artery walls, skin, intestines and the uterus.--COL3A1).
The collagen in connective tissue helps tissues resist deformation. Collagen is an important contributor to the physical strength of skin, joints, muscles, ligaments, blood vessels and visceral organs; abnormal collagen renders these structures more elastic. The severity of the mutation can be life-threatening, but many EDS patients die from other complications caused by the illness. There is no cure, and treatment is supportive, including close monitoring of the digestive, excretory and particularly the cardiovascular systems. Occupational and physical therapy, bracing, and corrective surgery may help with the frequent injuries and pain that tend to develop in certain types of EDS, although extra caution and special practices are advised to prevent permanent damage.
The features of EDS were first described by Hippocrates in 400 BC. The syndrome is named after two physicians, Edvard Ehlers from Denmark, and Henri-Alexandre<unk>  from France, who described it at the turn of the 20th century.
Ehlers–Danlos syndrome
Ehlers-Danlos syndrome
Ataxia telangiectasia
Klein-Levin syndrome
Singleton-Merten syndrome
Kearns-Sayer syndrome
Senior-Løken syndrome
Bernard-Soulier syndrome