0-4 wk old, <1200 g
Dose: 50mg/kg/day IV divided q12h
<1 wk old, 1200-2000 g
Dose: 50mg/kg/day IV divided q12h
<1 wk old, >2000 g
Dose: 75mg/kg/day IV divided q8h
1 wk old-1 mo, 1200-2000 g
Dose: 75mg/kg/day IV divided q8h
1 wk old-1 mo, >2000 g
Dose: 100mg/kg/day IV divided q6h
1 mo-16 yo
Dose: 50-100mg/kg/day IV divided q6h if mild-mod. infection; 100-200mg/kg/day IV divided q4-6h if severe infection; Max: 12 g/day
[1 mo-16 yo]
Dose: 200mg/kg/day IV divided q4-6h x6wk; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x3-5 days
[1 mo-16 yo]
Dose: 200mg/kg/day IV divided q4-6h x6wk or longer; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x2wk and rifampin
No adjustment unless concomitant hepatic impairment
CrCl 10-29: 9-25mg/kg q6h if concomitant hepatic impairment; CrCl <10: 7.5-15mg/kg q6h if concomitant hepatic impairment
Consider decrease dose if concomitant renal impairment
Nafcillin
Vancomycin
Piperacillin
Meropenem
Oxacillin
Aztreonam
Cefepime
Ampicillin