Decontamination with removal of clothing and irrigation as needed
Constant body temperature monitoring, cardiac monitor, IV access, and code cart to bedside
Activated charcoal if within 1 hour of ingestion
No evidence for or against multiple doses of charcoal or whole bowel irrigation
Aggressive IVF administration (cooled if possible)
Vasopressors with cardiovascular collapse non-responsive to IVF
Treat methemoglobinemia as needed
No evidence for or against multiple doses of charcoal or whole bowel irrigation
External cooling with blankets, ice, and cooling devices
Cool IVF
Control agitation (adds to hyperthermia)
Benzodiazepines should be administered as needed
Paralyze and intubate if not controlled, but maintain continuous and aggressive sedation
Dantrolene has been used to manage DNP hyperthermia
Paralyze and intubate if not controlled, but maintain continuous and aggressive sedation
Dinitrophenol toxicity
Critical
Acrylonitrile toxicity
Sepsis
Carbon disulfide toxicity
PNA with respiratory failure
Lewisite toxicity
Peritonitis