Anti-amoeba therapy (CDC recommendations at: https://www.cdc.gov/parasites/naegleria/treatment-hcp.html)
Amphotericin B: 1.5mg/kg/day divided in 2 doses for 3 days followed by 1mg/kg/day IV as one dose for 11 days
Intrathecal Amphotericin B: 1.5mg once daily for 2 days followed by 1mg/day every other day for 8 days
Azithromycin: 10mg/kg/day once daily IV/PO for 28 days, max dose 500mg/day
Fluconazole: 10mg/kg/day once daily IV/PO for 28 days, max dose 600mg/day
Rifampin: 10mg/kg/day once daily IV/PO for 28 days, max dose 500mg/day
Miltefosine: 50mg PO BID (<45kg) or TID (>45kg) for 28 days
Dexamethasone: 0.6mg/kg/day IV for 4 days
Therapeutic hypothermia
Elevated ICP management
Hyperosmolar therapy (hypertonic saline, mannitol)
EVD placement
CSF removal
Infectious disease consultation
Amphotericin B: 1.5mg/kg/day divided in 2 doses for 3 days followed by 1mg/kg/day IV as one dose for 11 days
Intrathecal Amphotericin B: 1.5mg once daily for 2 days followed by 1mg/day every other day for 8 days
Azithromycin: 10mg/kg/day once daily IV/PO for 28 days, max dose 500mg/day
Fluconazole: 10mg/kg/day once daily IV/PO for 28 days, max dose 600mg/day
Rifampin: 10mg/kg/day once daily IV/PO for 28 days, max dose 500mg/day
Miltefosine: 50mg PO BID (<45kg) or TID (>45kg) for 28 days
Hyperosmolar therapy (hypertonic saline, mannitol)
EVD placement
CSF removal
Primary Amebic Meningoencephalitis
Encephalitis
Drug induced aseptic meningitis
Meningitis
Neoplastic meningitis
Brain abscess
Limbic encephalitis
Sepsis