Different classifications of<unk>  based on patient population
Associated with HHV-8
Most common cancer in HIV/AIDS patients<unk>  can be unmasked or induced by initiation of steroids or HAART
Cutaneous lower extremity lesions most common presentation<unk>  is an AIDS-defining illness
Treat with HAART and/or chemo
First described by Hungarian Dr. Moritz<unk>  in 1872; rare until 1980s with emergence of HIV/AIDS (1981 cluster of<unk>  in young men in NYC and California; 1982 listed as AIDS-defining illness by CDC)
Human Herpesvirus 8 (HHV8)
Large, double-stranded DNA virus
Necessary but NOT sufficient to cause disease
Also associated with body-cavity based lymphomas, multicentric Castleman’s disease (angiofollicular lymph node hyperplasia)
Large, double-stranded DNA virus
Necessary but NOT sufficient to cause disease
Also associated with body-cavity based lymphomas, multicentric Castleman’s disease (angiofollicular lymph node hyperplasia)
Classic<unk> ’s (CK)
Indolent, chronic form, rarely disseminated
Skin most commonly effected, lower extremities
~3:1 Male:Female, Age > 60 years old with Mediterranean, Eastern European or Middle Eastern origin
Indolent, chronic form, rarely disseminated
Skin most commonly effected, lower extremities
~3:1 Male:Female, Age > 60 years old with Mediterranean, Eastern European or Middle Eastern origin
Endemic<unk>  (Africa)
Male adults or children of both sexes
Equatorial/Sub-Saharan Africa
Aggressive form with lymph node involvement (lymphedema)
27%, 35%, and 24% of total cancer burden in Uganda, Zimbabwe and Mozambique, respectively
Male adults or children of both sexes
Equatorial/Sub-Saharan Africa
Aggressive form with lymph node involvement (lymphedema)
27%, 35%, and 24% of total cancer burden in Uganda, Zimbabwe and Mozambique, respectively
AIDS-KS
Developed countries: Men who have sex with men
Developing countries: Heterosexual men and women (Africa)
Aggressive disease – most commonly in lungs, gastrointestinal tract, mouth, and genitalia
Most common cancer in HIV/AIDS patients
Developed countries: Men who have sex with men
Developing countries: Heterosexual men and women (Africa)
Aggressive disease – most commonly in lungs, gastrointestinal tract, mouth, and genitalia
Most common cancer in HIV/AIDS patients
Iatrogenic due to immunosuppression – Most commonly organ transplant-associated
Increased risk after solid organ transplantation
Transplant itself may transmit HHV-8 infection
Male > Female (3.3:1), average age 43 yo
Cutaneous lesion presentation most common
More common in liver than kidney transplant patients
Increased risk after solid organ transplantation
Transplant itself may transmit HHV-8 infection
Male > Female (3.3:1), average age 43 yo
Cutaneous lesion presentation most common
More common in liver than kidney transplant patients
Immune Reconstitution Inflammatory Syndrome (IRIS) Phenomenon
Initiation of retroviral therapy can cause the development of<unk> 
True unmasked<unk> -IRIS begins within 6 months of initiating therapy, and the rates remain unclear
Initiation of retroviral therapy can cause the development of<unk> 
True unmasked<unk> -IRIS begins within 6 months of initiating therapy, and the rates remain unclear
Kaposi's sarcoma
Cutaneous Lesions:
Ewing sarcoma
Bacillary angiomatosis
Melanoma
Purpura
Osteosarcoma
Hematomas