Fluorouracil adjuvant treatment, adv. colorectal CA
high dose: 200mg/m^2 IV QD x5 days
low dose: 20mg/m^2 IV QD x5 days
high dose: 200mg/m^2 IV QD x5 days
low dose: 20mg/m^2 IV QD x5 days<unk>  rescue, high-dose methotrexate
normal methotrexate elimination: 15mg PO/IM/IV q6h x10 doses
delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV
normal methotrexate elimination: 15mg PO/IM/IV q6h x10 doses
delayed late methotrexate elimination: 15mg PO/IM/IV q6h; Max: 25mg/dose PO, May give higher doses IM/IV
Delayed early methotrexate elimination and/or acute renal injury: 150mg IV q3h until methotrexate level <1 micromolar, then 15mg IV q3h<unk>  rescue, methotrexate overdose: 10mg/m^2 PO/IM/IV q6h
Folate antagonist overdose
pemetrexed: 50mg/m^2 IV q6h x8 days; Start: 100mg/m^2 IV x1
pyrimethamine, trimethoprim: 5-15mg PO/IM/IV QD until hematopoiesis restored
pemetrexed: 50mg/m^2 IV q6h x8 days; Start: 100mg/m^2 IV x1
pyrimethamine, trimethoprim: 5-15mg PO/IM/IV QD until hematopoiesis restored
Megaloblastic anemia, folate-deficient: <1mg IM/IV QD
Max: 1mg/day
Max: 1mg/day
Leucovorin
Levoleucovorin
Deferoxamine
Pyridoxine
Hydroxocobalamin
Penicillamine
Folic acid
Succimer