LFTs
Alkaline phosphatase is usually elevated with mild elevations in aminotransferases
Bilirubin is typically normal, except when common hepatic duct or common bile duct is involved in late stages of disease
Perinuclear antineutrophil cytoplasmic antibody (pANCA) positive in 2/3rds of cases
Cholangiography
Diagnosis made by ERCP or MRCP, which demonstrates strictures or beading of the intrahepatic or extrahepatic bile ducts
Liver biopsy typically shows pericholangitis and periductual fibrosis but is often not diagnostic in early disease
Alkaline phosphatase is usually elevated with mild elevations in aminotransferases
Bilirubin is typically normal, except when common hepatic duct or common bile duct is involved in late stages of disease
Primary sclerosing cholangitis
Amebiasis
Ischemic hepatitis
Autoimmune hepatitis
Choledocholithiasis
Viral hepatitis
Non-alcoholic steatohepatitis
Acute alcoholic hepatitis