LFTs
ALT/AST 1.5-50 times normal
Mild to moderate elevations in bilirubin and alk phos
CBC
+/- mild leukopenia,
+/- normocytic or hemolytic anemia
+/- thrombocytopenia
BMP: evaluate for electrolyte derangements, hypoglycemia, hepatorenal syndrome
PT/INR
Ammonia if suspect hepatic encephalopathy
Paracentesis if suspect SBP
Autoantibodies: may have positive ANA, SMA, LKM-1, and/or anti-LC1
Evaluate for other causes of liver disease, if not previously diagnosed with<unk> :
Viral hepatitis serologies
Acetaminophen level
Consider RUQ ultrasound
Definitive diagnosis usually by liver biopsy
ALT/AST 1.5-50 times normal
Mild to moderate elevations in bilirubin and alk phos
+/- mild leukopenia,
+/- normocytic or hemolytic anemia
+/- thrombocytopenia
Viral hepatitis serologies
Acetaminophen level
Autoimmune hepatitis
Viral hepatitis
Acute alcoholic hepatitis, alcoholic liver disease
Ischemic hepatitis
Acetaminophen toxicity and other drug-induced hepatotoxicity 
Non-alcoholic steatohepatitis
Mushroom toxicity
Amebiasis