<unk> (BFR) syndrome, sometimes called<unk>  derangement, is a medical condition characterized by<unk>  loss (or occasionally<unk>  gain), often in the cheeks or face.  BFR most often occurs in HIV/AIDS patients undergoing antiretroviral therapy.
No firm definition of<unk> syndrome exists as yet.  At least four syndromes have been described that are characterized by the accumulation of<unk> , and one by the loss of<unk> ; combinations of these may occur in an individual. Gender, age, and pre-therapy<unk>  weight appear to influence the severity of BFR in patients.  BFR is distinct from lipodystrophy, which simply refers to<unk>  loss.
Body fat redistribution 
Heat transfer
Thermoregulation
Body shaping
Respiratory compensation
Osteostimulation
Androgen suppression
Differentiating Metabolic syndrome from other diseases