<unk>  is an an alpha-adrenergic receptor agonist with a beta-adrenergic receptor inhibitor that is FDA approved for the treatment of glaucoma, ocular hypertension; in patients requiring adjunctive or replacement therapy.   Common adverse reactions include somnolence, allergic conjunctivitis, burning sensation in eye, conjunctival hyperemia, acute follicular conjunctivitis, itching of the eye.
Brimonidine tartrate and Timolol maleate
Dorzolamide and Timolol Ophthalmic
Lidocaine and Hydrocortisone
Oxymetazoline hydrochloride
Dorzolamide
Pilocarpine 
Brinzolamide
Ergotamine and caffeine 