<unk> s are a superfamily of poorly understood ion<unk> s consisting of approximately 13 members.
It is now recognised that<unk> s display a variety of important physiological and cellular roles that include regulation of pH, volume homeostasis, organic solute transport, cell migration, cell proliferation and differentiation. A number of different gene products have been shown to function as<unk> s. Based on sequence homology the<unk> s can be subdivided into a number of groups. The importance of one such group, the CLC family of<unk> s, can be seen from the diseases that develop when the<unk>  does not function normally.
Chloride channel
Calcium channel
Sodium channel
Ion transporter
Light-gated ion channel
Ion channel
Cyclic nucleotide-gated ion channel
Voltage-gated ion channel