It is understood that Behçet<unk>  is the result of vasculitis. It involves all sizes of blood vessels ( small, medium, and large). Arteries and veins are both involved in Behçet<unk> . Major mechanisms in pathogenesis of Behçet<unk>  include environmental factors such as bacteria, viruses, and heat shock proteins (present in some bacteria and some of the bacterial HSPs share similaritis with human HSPs). Streptococcus sanguinis, streptococcus pyogenes, and mycobacterium tuberculosis produce HSPs that trigger anti HSP60 and anti HSP65 antibodies and then they target human HSPs and immune response such as uveitis in parenchymal neuro-Behçet<unk> , CD4+ T cells activation, secretion of cytokines and inflammation. Genes involved in the pathogenesis of Behçet<unk>  include human leukocyte antigens, particularly HLA-B51.
Behçet's disease pathophysiology
Behçet's disease risk factors
Sjögren's syndrome pathophysiology
Behçet's disease laboratory findings
Herpes simplex pathophysiology
Behçet's disease classification
Behçet's disease epidemiology and demographics
Adult-onset Still's disease pathophysiology