<unk>  (INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as<unk>  hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.
The usual dose is 20 mg every 4–6 hours.[citation needed] Possible side effects of<unk> , especially in overdose, may include drowsiness, vertigo, delirium, disorientation, loss of consciousness, and confusion.<unk>  has recently garnered interest as a potential psychiatric drug. It is being investigated in depression, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder (ADHD). Through inhibition of GIRK channels,<unk>  increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents.
Tipepidine
Meperidine 
Deserpidine
Esketamine
Betanidine
Propofol
Midazolam 
Fentanyl 