Methods of the present invention will be useful for preventing and treating the development of {HEAD ~ multiple organ failure} resulting from burn, disseminated intravascular coagulation , circulatory failure, hemorrhagic shock, infectious disease, acute pancreatitis, {TAIL ~ ischemic disorder}, hepatorenal syndrome, gastrointestinal hemorrhage, nutritional metabolic failure, terminal cancer, acquired immunodeficiency syndrome , deterioration of systemic conditions due to radiation affection, and cachexia 
Methods of the present invention will be useful for preventing and treating the development of { HEAD ~ multiple organ failure } resulting from burn , disseminated intravascular coagulation , circulatory failure , hemorrhagic shock , infectious disease , acute pancreatitis , { TAIL ~ ischemic disorder } , hepatorenal syndrome , gastrointestinal hemorrhage , nutritional metabolic failure , terminal cancer , acquired immunodeficiency syndrome , deterioration of systemic conditions due to radiation affection , and cachexia
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