The present invention relates to {HEAD ~ human papillomavirus virus} like {TAIL ~ particles} , and in particular, expressing optimally modified HPV 16 L1, HPV 58 L1, HPV 18 L1, HPV 6 L1 and HPV 11 L1 genes in insect cells to produce proteins encoded by the above said five genes, and to obtain VLPs of HPV 16, 58, 18, 6 and 11 Lls 
The present invention relates to { HEAD ~ human papillomavirus virus } like { TAIL ~ particles } , and in particular , expressing optimally modified HPV 16 L1 , HPV 58 L1 , HPV 18 L1 , HPV 6 L1 and HPV 11 L1 genes in insect cells to produce proteins encoded by the above said five genes , and to obtain VLPs of HPV 16 , 58 , 18 , 6 and 11 Lls
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