In one embodiment, the present invention provides a method of solid phase synthesis that includes providing an azlactone functionalized support; reacting the azlactone {TAIL ~ functionalized support} with {HEAD ~ a linker molecule} to form a linker functionalized support having a linker attached to the azlactone functionalized support; and conducting one or more reactions on the linker functionalized support 
In one embodiment , the present invention provides a method of solid phase synthesis that includes providing an azlactone functionalized support ; reacting the azlactone { TAIL ~ functionalized support } with { HEAD ~ a linker molecule } to form a linker functionalized support having a linker attached to the azlactone functionalized support ; and conducting one or more reactions on the linker functionalized support
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