{HEAD ~ The compounds} of the invention are useful in {TAIL ~ the treatment} of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist 
{ HEAD ~ The compounds } of the invention are useful in { TAIL ~ the treatment } of disorders associated with the depletion of estrogen such as hot flashes , vaginal dryness , osteopenia and osteoporosis ; hormone sensitive cancers and hyperplasia of the breast , endometrium , cervix and prostate ; endometriosis , uterine fibroids , osteoarthritis and as contraceptive agents , alone or in combination with a progestogen or progestogen antagonist
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