A gas is introduced to controllably generate bubbles that reduce the density of the cell debris and create a buoyant flocculent phase that can be readily separated from, and thus provide, {HEAD ~ a substantially clarified fluid lysate phase} that is enriched in extrachromosomal DNA but substantially depleted of {TAIL ~ cellular proteins} and chromosomal DNA 
A gas is introduced to controllably generate bubbles that reduce the density of the cell debris and create a buoyant flocculent phase that can be readily separated from , and thus provide , { HEAD ~ a substantially clarified fluid lysate phase } that is enriched in extrachromosomal DNA but substantially depleted of { TAIL ~ cellular proteins } and chromosomal DNA
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