Concentrates of one of the coagulation factors II, V and VIII or {TAIL ~ a mixture} thereof or blood plasma free from one or more of the coagulation factors VII, IX, X, XI and XII can be prepared by adding {HEAD ~ a reducing substance} comprised of dithiothreitol, dithioerythritol, lipoic acid, mercaptoethanol, or a borohydride to blood or plasma, dithiothreitol being preferred 
Concentrates of one of the coagulation factors II , V and VIII or { TAIL ~ a mixture } thereof or blood plasma free from one or more of the coagulation factors VII , IX , X , XI and XII can be prepared by adding { HEAD ~ a reducing substance } comprised of dithiothreitol , dithioerythritol , lipoic acid , mercaptoethanol , or a borohydride to blood or plasma , dithiothreitol being preferred
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