b) causing {HEAD ~ the small molecule} to come into contact with {TAIL ~ IRS2} or a complex comprising IRS2 and other cellular proteins in the cell; and 
b ) causing { HEAD ~ the small molecule } to come into contact with { TAIL ~ IRS2 } or a complex comprising IRS2 and other cellular proteins in the cell ; and
OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH