Either of the aforementioned transgenic non human animals can be bred with animals having inactivated {HEAD ~ heavy and light chain loci} to produce {TAIL ~ a transgenic non human animal} that produces a fully human antibody and is incapable of producing an endogenous antibody 
Either of the aforementioned transgenic non human animals can be bred with animals having inactivated { HEAD ~ heavy and light chain loci } to produce { TAIL ~ a transgenic non human animal } that produces a fully human antibody and is incapable of producing an endogenous antibody
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