Methods of diagnosing whether an epithelial tissue is an abnormal tissue by determining an expression pattern for PML in the epithelial tissue; determining an expression pattern for nuclear bodies in the epithelial tissue; determining SUMO 1 colocalization and comparing {HEAD ~ the expression pattern} for PML and the expression pattern for nuclear bodies with {TAIL ~ a control} are disclosed 
Methods of diagnosing whether an epithelial tissue is an abnormal tissue by determining an expression pattern for PML in the epithelial tissue ; determining an expression pattern for nuclear bodies in the epithelial tissue ; determining SUMO 1 colocalization and comparing { HEAD ~ the expression pattern } for PML and the expression pattern for nuclear bodies with { TAIL ~ a control } are disclosed
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