{HEAD ~ Formation} of an ester or {TAIL ~ an amide} of the disulfide compound led to not only prolongation of the duration but also improvement of absorption characteristics as a result of increase of lipophilicity 
{ HEAD ~ Formation } of an ester or { TAIL ~ an amide } of the disulfide compound led to not only prolongation of the duration but also improvement of absorption characteristics as a result of increase of lipophilicity
HEAD HEAD HEAD HEAD HEAD REL OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH