Another aspect of the disclosure encompasses therapeutic compositions comprising at least one of the 4 quinolone compounds of the disclosure and in an amount that is effective, when administered to an animal or human subject as a single dose or as {HEAD ~ a series} of {TAIL ~ doses}, in reducing or eliminating a malarial parasite infection in the subject animal or human, or prophylactically prevents the establishment of such an infection 
Another aspect of the disclosure encompasses therapeutic compositions comprising at least one of the 4 quinolone compounds of the disclosure and in an amount that is effective , when administered to an animal or human subject as a single dose or as { HEAD ~ a series } of { TAIL ~ doses } , in reducing or eliminating a malarial parasite infection in the subject animal or human , or prophylactically prevents the establishment of such an infection
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH