Through the use of neutral organic solvents to inactivate endogenous enzyme activities , {HEAD ~ multiplexed extraction conditions} and combinatorial alterations in matrix stereoelectronic composition and analyte interactions, multiple suites of {TAIL ~ metabolites} were directly ionized and quantitated directly from biologic extracts without the need for prior chromatographic separation 
Through the use of neutral organic solvents to inactivate endogenous enzyme activities , { HEAD ~ multiplexed extraction conditions } and combinatorial alterations in matrix stereoelectronic composition and analyte interactions , multiple suites of { TAIL ~ metabolites } were directly ionized and quantitated directly from biologic extracts without the need for prior chromatographic separation
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