The present invention is directed to novel spiro benzochromene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes, vaginal dryness, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, degenerative brain diseases, cardiovascular diseases, cerebrovascular diseases, hormone sensitive cancers and hyperplasia , endometriosis, uterine fibroids, osteoarthritis; and as {TAIL ~ contraceptive agents} either alone or in combination with a {HEAD ~ progestogen} or progestogen antagonist 
The present invention is directed to novel spiro benzochromene derivatives , pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes , vaginal dryness , osteopenia , osteoporosis , hyperlipidemia , loss of cognitive function , degenerative brain diseases , cardiovascular diseases , cerebrovascular diseases , hormone sensitive cancers and hyperplasia , endometriosis , uterine fibroids , osteoarthritis ; and as { TAIL ~ contraceptive agents } either alone or in combination with a { HEAD ~ progestogen } or progestogen antagonist
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD OTH OTH OTH