I ribozyme comprising at least two modifiable recognition elements, wherein at least one of said recognition elements is complementary to the non native target sequence and at least one of said recognition elements stabilizes binding of the ribozyme to a trans excision splicing reaction intermediate product, and wherein {HEAD ~ the ribozyme} catalyzes {TAIL ~ a specific excision} of the non native target sequence in the absence of a guanosine cofactor and splices together the 5′ and 3′ ends of the substrate created by the excision 
I ribozyme comprising at least two modifiable recognition elements , wherein at least one of said recognition elements is complementary to the non native target sequence and at least one of said recognition elements stabilizes binding of the ribozyme to a trans excision splicing reaction intermediate product , and wherein { HEAD ~ the ribozyme } catalyzes { TAIL ~ a specific excision } of the non native target sequence in the absence of a guanosine cofactor and splices together the 5′ and 3′ ends of the substrate created by the excision
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