b) detecting the presence or absence of a variant Nod2 gene, wherein said variant Nod2 gene has a nucleic acid sequence having a cytosine insertion at position 3124 of {HEAD ~ SEQ ID NO:1}, wherein the presence of a cytosine insertion at position 3124 of SEQ ID NO:1 is indicative of {TAIL ~ said subject} having an increased risk of developing Crohns disease 
b ) detecting the presence or absence of a variant Nod2 gene , wherein said variant Nod2 gene has a nucleic acid sequence having a cytosine insertion at position 3124 of { HEAD ~ SEQ ID NO:1 } , wherein the presence of a cytosine insertion at position 3124 of SEQ ID NO:1 is indicative of { TAIL ~ said subject } having an increased risk of developing Crohns disease
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