Known sequences can be used in the method of {HEAD ~ the present invention} for {TAIL ~ the sequences} that encode the antibody heavy chain and light chain for introduction of mutation 
Known sequences can be used in the method of { HEAD ~ the present invention } for { TAIL ~ the sequences } that encode the antibody heavy chain and light chain for introduction of mutation
OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH