In some specific embodiments, {HEAD ~ the C 3′ substituted anthracycline compounds} of {TAIL ~ the present invention} have the general formula: 
In some specific embodiments , { HEAD ~ the C 3′ substituted anthracycline compounds } of { TAIL ~ the present invention } have the general formula :
OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH