The present invention concerns the discovery that proteins encoded by {HEAD ~ a family} of {TAIL ~ vertebrate genes}, termed here hedgehog related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates 
The present invention concerns the discovery that proteins encoded by { HEAD ~ a family } of { TAIL ~ vertebrate genes } , termed here hedgehog related genes , comprise morphogenic signals produced by embryonic patterning centers , and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates
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