{HEAD ~ Either} of the aforementioned transgenic non human animals can be bred with {TAIL ~ animals} having inactivated heavy and light chain loci to produce a transgenic non human animal that produces a fully human antibody and is incapable of producing an endogenous antibody 
{ HEAD ~ Either } of the aforementioned transgenic non human animals can be bred with { TAIL ~ animals } having inactivated heavy and light chain loci to produce a transgenic non human animal that produces a fully human antibody and is incapable of producing an endogenous antibody
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