By performing the adding step, there is {TAIL ~ downregulating} of the expression of colony intracellular bound bFGF, and by performing the downregulating step, there is {HEAD ~ inhibiting} of bFGF promoted growth of cells in the colony 
By performing the adding step , there is { TAIL ~ downregulating } of the expression of colony intracellular bound bFGF , and by performing the downregulating step , there is { HEAD ~ inhibiting } of bFGF promoted growth of cells in the colony
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