In one embodiment, the invention provides a non naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, {HEAD ~ CO2} and H2 to acetyl coenzyme A , methyl tetrahydrofolate or other desired products, wherein the microorganism lacks {TAIL ~ the ability} to convert CO or CO2 and H2 to acetyl CoA or methyl THF in the absence of the one or more exogenous proteins 
In one embodiment , the invention provides a non naturally occurring microorganism , comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO , { HEAD ~ CO2 } and H2 to acetyl coenzyme A , methyl tetrahydrofolate or other desired products , wherein the microorganism lacks { TAIL ~ the ability } to convert CO or CO2 and H2 to acetyl CoA or methyl THF in the absence of the one or more exogenous proteins
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