{TAIL ~ The methods} and formulations comprise modified release elements, providing for drug delivery to {HEAD ~ the affected or desired area} 
{ TAIL ~ The methods } and formulations comprise modified release elements , providing for drug delivery to { HEAD ~ the affected or desired area }
TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD