Preferred are those methods as described, wherein the disease state is selected from {HEAD ~ the group} consisting of: NPC1; pathogenic lipid accumulation; vascular disease; heart attack; stroke; overweight; obesity; diabetes; metabolic syndrome; thyroid malfunction; medication side effect; arthrosclerosis; heart failure; heart disease; Alzheimers disease; Parkinson disease; Huntington disease; Tay Sachs disease and {TAIL ~ neurodegenerative disease} 
Preferred are those methods as described , wherein the disease state is selected from { HEAD ~ the group } consisting of : NPC1 ; pathogenic lipid accumulation ; vascular disease ; heart attack ; stroke ; overweight ; obesity ; diabetes ; metabolic syndrome ; thyroid malfunction ; medication side effect ; arthrosclerosis ; heart failure ; heart disease ; Alzheimers disease ; Parkinson disease ; Huntington disease ; Tay Sachs disease and { TAIL ~ neurodegenerative disease }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL REL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL