intratumorally or systemically administering to the subject in need thereof an effective amount of a fusogenic mutant Herpes Simplex Virus Type 2 , wherein the fusogenic mutant {HEAD ~ HSV} 2 comprises a modified ICP10 coding region lacking nucleotides 1 to 1204 of {TAIL ~ an endogenous ICP10 coding region}, wherein said fusogenic mutant HSV 2 comprises the modified ICP10 operably linked to an endogenous or a constitutive promoter and expresses a modified ICP10 polypeptide that lacks protein kinase activity but retains ribonucleotide reductase activity, and 
intratumorally or systemically administering to the subject in need thereof an effective amount of a fusogenic mutant Herpes Simplex Virus Type 2 , wherein the fusogenic mutant { HEAD ~ HSV } 2 comprises a modified ICP10 coding region lacking nucleotides 1 to 1204 of { TAIL ~ an endogenous ICP10 coding region } , wherein said fusogenic mutant HSV 2 comprises the modified ICP10 operably linked to an endogenous or a constitutive promoter and expresses a modified ICP10 polypeptide that lacks protein kinase activity but retains ribonucleotide reductase activity , and
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