Optionally, the pharmaceutical composition of the invention may comprise a compound of formula I combined with one or more other pharmacologically active compounds, e.g. an antidiabetic or other pharmacologically active material, including compounds for the treatment and prophylaxis of insulin resistance and diseases wherein {HEAD ~ insulin resistance} is {TAIL ~ the pathophysiological mechanism} 
Optionally , the pharmaceutical composition of the invention may comprise a compound of formula I combined with one or more other pharmacologically active compounds , e.g. an antidiabetic or other pharmacologically active material , including compounds for the treatment and prophylaxis of insulin resistance and diseases wherein { HEAD ~ insulin resistance } is { TAIL ~ the pathophysiological mechanism }
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