Optionally, the pharmaceutical composition of the invention may comprise a compound of formula I combined with one or more other pharmacologically active compounds, e.g. an antidiabetic or other pharmacologically active material, including {HEAD ~ compounds} for {TAIL ~ the treatment} and prophylaxis of insulin resistance and diseases wherein insulin resistance is the pathophysiological mechanism 
Optionally , the pharmaceutical composition of the invention may comprise a compound of formula I combined with one or more other pharmacologically active compounds , e.g. an antidiabetic or other pharmacologically active material , including { HEAD ~ compounds } for { TAIL ~ the treatment } and prophylaxis of insulin resistance and diseases wherein insulin resistance is the pathophysiological mechanism
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