The object of the present invention is achieved by the use of individual or a mixture of fumaric acid derivative for preparing a pharmaceutical composition for treating mitochondrial diseases, especially for treating {HEAD ~ Alzheimers disease}, {TAIL ~ Parkinsons syndrome}, Chorea Huntington disease, retinopathia pigmentosa and mitochondrial encephalomyopathy 
The object of the present invention is achieved by the use of individual or a mixture of fumaric acid derivative for preparing a pharmaceutical composition for treating mitochondrial diseases , especially for treating { HEAD ~ Alzheimers disease } , { TAIL ~ Parkinsons syndrome } , Chorea Huntington disease , retinopathia pigmentosa and mitochondrial encephalomyopathy
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