The nucleic acid sequences provided herein are useful in, for example, identifying and isolating functional homologs of AE5′ and AE3′, and amplifying at least a portion of AE5′ and AE3′. Importantly, the nucleic acid sequences of the invention are also useful in age related expression and liver specific expression of a nucleotide sequence of interest in an animal, in gene therapy, and in reducing expression of {HEAD ~ factor IX} in {TAIL ~ an animal} 
The nucleic acid sequences provided herein are useful in , for example , identifying and isolating functional homologs of AE5′ and AE3′ , and amplifying at least a portion of AE5′ and AE3′. Importantly , the nucleic acid sequences of the invention are also useful in age related expression and liver specific expression of a nucleotide sequence of interest in an animal , in gene therapy , and in reducing expression of { HEAD ~ factor IX } in { TAIL ~ an animal }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL