Preferred are those methods as described, wherein the disease state is selected from the group consisting of: NPC1; pathogenic lipid accumulation; {HEAD ~ vascular disease}; heart attack; stroke; {TAIL ~ overweight}; obesity; diabetes; metabolic syndrome; thyroid malfunction; medication side effect; arthrosclerosis; heart failure; heart disease; Alzheimers disease; Parkinson disease; Huntington disease; Tay Sachs disease and neurodegenerative disease 
Preferred are those methods as described , wherein the disease state is selected from the group consisting of : NPC1 ; pathogenic lipid accumulation ; { HEAD ~ vascular disease } ; heart attack ; stroke ; { TAIL ~ overweight } ; obesity ; diabetes ; metabolic syndrome ; thyroid malfunction ; medication side effect ; arthrosclerosis ; heart failure ; heart disease ; Alzheimers disease ; Parkinson disease ; Huntington disease ; Tay Sachs disease and neurodegenerative disease
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH