The nucleic acid sequences provided herein are useful in, for example, identifying and isolating functional homologs of AE5′ and AE3′, and amplifying {HEAD ~ at least a portion} of AE5′ and {TAIL ~ AE3′.} Importantly, the nucleic acid sequences of the invention are also useful in age related expression and liver specific expression of a nucleotide sequence of interest in an animal, in gene therapy, and in reducing expression of factor IX in an animal 
The nucleic acid sequences provided herein are useful in , for example , identifying and isolating functional homologs of AE5′ and AE3′ , and amplifying { HEAD ~ at least a portion } of AE5′ and { TAIL ~ AE3′. } Importantly , the nucleic acid sequences of the invention are also useful in age related expression and liver specific expression of a nucleotide sequence of interest in an animal , in gene therapy , and in reducing expression of factor IX in an animal
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD REL OTH OTH TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH