In order to determine precise T cell epitopes by, for example, fine mapping techniques, a peptide having Der p VII or Der f VII T cell stimulating activity and thus comprising at least one T cell epitope as determined by T cell biology techniques is modified by {TAIL ~ addition} or deletion of amino acid residues at either the amino or carboxy terminus of {HEAD ~ the peptide} and tested to determine a change in T cell reactivity to the modified peptide 
In order to determine precise T cell epitopes by , for example , fine mapping techniques , a peptide having Der p VII or Der f VII T cell stimulating activity and thus comprising at least one T cell epitope as determined by T cell biology techniques is modified by { TAIL ~ addition } or deletion of amino acid residues at either the amino or carboxy terminus of { HEAD ~ the peptide } and tested to determine a change in T cell reactivity to the modified peptide
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