The method 1, wherein said tropic acid or topically effective salt thereof is applied periodically for {HEAD ~ a period} of {TAIL ~ time} sufficient to achieve at least a clinically discernable reduction of said wrinkle 
The method 1 , wherein said tropic acid or topically effective salt thereof is applied periodically for { HEAD ~ a period } of { TAIL ~ time } sufficient to achieve at least a clinically discernable reduction of said wrinkle
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH