In one embodiment, the present invention provides a method of {HEAD ~ solid phase synthesis} that includes providing {TAIL ~ an azlactone functionalized support}; reacting the azlactone functionalized support with a linker molecule to form a linker functionalized support having a linker attached to the azlactone functionalized support; and conducting one or more reactions on the linker functionalized support 
In one embodiment , the present invention provides a method of { HEAD ~ solid phase synthesis } that includes providing { TAIL ~ an azlactone functionalized support } ; reacting the azlactone functionalized support with a linker molecule to form a linker functionalized support having a linker attached to the azlactone functionalized support ; and conducting one or more reactions on the linker functionalized support
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