A method of determining whether a small molecule is an activator or {TAIL ~ an inhibitor} of insulin receptor substrate 2 , wherein said activator or inhibitor binds to IRS2 or to a complex comprising IRS2 and an IRS2 binding protein and cannot bind to the non IRS2 proteins in the absence of {HEAD ~ IRS2}, which comprises: 
A method of determining whether a small molecule is an activator or { TAIL ~ an inhibitor } of insulin receptor substrate 2 , wherein said activator or inhibitor binds to IRS2 or to a complex comprising IRS2 and an IRS2 binding protein and can not bind to the non IRS2 proteins in the absence of { HEAD ~ IRS2 } , which comprises :
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