In one aspect, the invention provides a method for screening a compound that increases spine/excitatory synapse formation and numbers, the method comprising contacting {HEAD ~ Ephexin5} with {TAIL ~ a test compound} and selecting the compound that inhibits Rho GEF activity of Ephexin5 
In one aspect , the invention provides a method for screening a compound that increases spine / excitatory synapse formation and numbers , the method comprising contacting { HEAD ~ Ephexin5 } with { TAIL ~ a test compound } and selecting the compound that inhibits Rho GEF activity of Ephexin5
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH