{TAIL ~ A pharmaceutical composition} comprising at least one pharmaceutically acceptable carrier or adjuvant and an effective TNF {HEAD ~ α} release inhibiting amount of a substituted 2,4 imidazolidinedione compound corresponding to the formula I ##STR24## wherein R1 represents C1 6 alkyl or C3 6 cycloalkyl 
{ TAIL ~ A pharmaceutical composition } comprising at least one pharmaceutically acceptable carrier or adjuvant and an effective TNF { HEAD ~ α } release inhibiting amount of a substituted 2,4 imidazolidinedione compound corresponding to the formula I # # STR24 # # wherein R1 represents C1 6 alkyl or C3 6 cycloalkyl
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