{TAIL ~ The determination} of {HEAD ~ an effective dose} is well within the capability of those skilled in the art 
{ TAIL ~ The determination } of { HEAD ~ an effective dose } is well within the capability of those skilled in the art
TAIL TAIL TAIL TAIL TAIL TAIL OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH