A method of determining whether a small molecule is an activator or {HEAD ~ an inhibitor} of {TAIL ~ insulin receptor substrate} 2 , wherein said activator or inhibitor binds to IRS2 or to a complex comprising IRS2 and an IRS2 binding protein and cannot bind to the non IRS2 proteins in the absence of IRS2, which comprises: 
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A method of determining whether a small molecule is an activator or { HEAD ~ an inhibitor } of { TAIL ~ insulin receptor substrate } 2 , wherein said activator or inhibitor binds to IRS2 or to a complex comprising IRS2 and an IRS2 binding protein and can not bind to the non IRS2 proteins in the absence of IRS2 , which comprises :
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