A method of determining whether a small molecule is an activator or an inhibitor of insulin receptor substrate 2 , wherein said activator or {TAIL ~ inhibitor} binds to {HEAD ~ IRS2} or to a complex comprising IRS2 and an IRS2 binding protein and cannot bind to the non IRS2 proteins in the absence of IRS2, which comprises: 
A method of determining whether a small molecule is an activator or an inhibitor of insulin receptor substrate 2 , wherein said activator or { TAIL ~ inhibitor } binds to { HEAD ~ IRS2 } or to a complex comprising IRS2 and an IRS2 binding protein and can not bind to the non IRS2 proteins in the absence of IRS2 , which comprises :
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