Preferred are those methods as described, wherein the disease state is selected from the group consisting of: NPC1; pathogenic lipid accumulation; vascular disease; heart attack; stroke; overweight; obesity; diabetes; metabolic syndrome; {TAIL ~ thyroid malfunction}; medication side effect; arthrosclerosis; heart failure; {HEAD ~ heart disease}; Alzheimers disease; Parkinson disease; Huntington disease; Tay Sachs disease and neurodegenerative disease 
Preferred are those methods as described , wherein the disease state is selected from the group consisting of : NPC1 ; pathogenic lipid accumulation ; vascular disease ; heart attack ; stroke ; overweight ; obesity ; diabetes ; metabolic syndrome ; { TAIL ~ thyroid malfunction } ; medication side effect ; arthrosclerosis ; heart failure ; { HEAD ~ heart disease } ; Alzheimers disease ; Parkinson disease ; Huntington disease ; Tay Sachs disease and neurodegenerative disease
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