According to the methods, an unrearranged human immunoglobulin heavy chain transgene is introduced into the germline of a non human animal to produce a transgenic non human animal having {HEAD ~ the transgene} in {TAIL ~ its somatic and germ cells} 
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According to the methods , an unrearranged human immunoglobulin heavy chain transgene is introduced into the germline of a non human animal to produce a transgenic non human animal having { HEAD ~ the transgene } in { TAIL ~ its somatic and germ cells }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL