The development of 5 HT3 agents originated from work carried out with {TAIL ~ metoclopramide} , which is marketed for use in {HEAD ~ the treatment} of nausea and vomiting at high doses 
The development of 5 HT3 agents originated from work carried out with { TAIL ~ metoclopramide } , which is marketed for use in { HEAD ~ the treatment } of nausea and vomiting at high doses
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