A process of preparing radical anions which comprises reacting sodium and {HEAD ~ a polycyclic aromatic compound} in a reaction solvent to prepare radical anions and supplying androstane 1,4 diene 3,17 dione 17 acetal into the obtained reaction mixture to reduce the same into an estrone acetal, characterized in that a solvent comprising polyethers having three or more ether bonds and maintained at {TAIL ~ a concentration} higher than a predetermined value is used as the reaction solvent and the reaction is carried out at a temperature of from the melting point of sodium to 105° C 
A process of preparing radical anions which comprises reacting sodium and { HEAD ~ a polycyclic aromatic compound } in a reaction solvent to prepare radical anions and supplying androstane 1,4 diene 3,17 dione 17 acetal into the obtained reaction mixture to reduce the same into an estrone acetal , characterized in that a solvent comprising polyethers having three or more ether bonds and maintained at { TAIL ~ a concentration } higher than a predetermined value is used as the reaction solvent and the reaction is carried out at a temperature of from the melting point of sodium to 105 ° C
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