According to the methods, an unrearranged human immunoglobulin heavy chain transgene is introduced into the germline of {HEAD ~ a non human animal} to produce {TAIL ~ a transgenic non human animal} having the transgene in its somatic and germ cells 
to produce
According to the methods , an unrearranged human immunoglobulin heavy chain transgene is introduced into the germline of { HEAD ~ a non human animal } to produce { TAIL ~ a transgenic non human animal } having the transgene in its somatic and germ cells
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