b) causing the small molecule to come into {HEAD ~ contact} with IRS2 or {TAIL ~ a complex comprising IRS2} and other cellular proteins in the cell; and 
with
b ) causing the small molecule to come into { HEAD ~ contact } with IRS2 or { TAIL ~ a complex comprising IRS2 } and other cellular proteins in the cell ; and
OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD REL OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH