In one aspect, the invention provides a method for screening a compound that increases spine/excitatory synapse formation and numbers, the method comprising contacting Ephexin5 with a test compound and selecting the compound that inhibits {HEAD ~ Rho GEF activity} of {TAIL ~ Ephexin5} 
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In one aspect , the invention provides a method for screening a compound that increases spine / excitatory synapse formation and numbers , the method comprising contacting Ephexin5 with a test compound and selecting the compound that inhibits { HEAD ~ Rho GEF activity } of { TAIL ~ Ephexin5 }
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