Either of {TAIL ~ the aforementioned transgenic non human animals} can be bred with animals having inactivated {HEAD ~ heavy and light chain loci} to produce a transgenic non human animal that produces a fully human antibody and is incapable of producing an endogenous antibody 
Either of { TAIL ~ the aforementioned transgenic non human animals } can be bred with animals having inactivated { HEAD ~ heavy and light chain loci } to produce a transgenic non human animal that produces a fully human antibody and is incapable of producing an endogenous antibody
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