Compound VI is contacted with {HEAD ~ 2.4 difluorobenzylamine} under coupling {TAIL ~ conditions} to form —N 3 methyl 6 5,7 dioxo 2,3,5,7,11,11a hexahydrooxazolopyridopyrazine 8 carboxamide  
under coupling
Compound VI is contacted with { HEAD ~ 2.4 difluorobenzylamine } under coupling { TAIL ~ conditions } to form — N 3 methyl 6 5,7 dioxo 2,3,5,7,11,11a hexahydrooxazolopyridopyrazine 8 carboxamide
OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL REL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH