In order to determine precise T cell epitopes by, for example, fine mapping techniques, a peptide having Der p VII or Der f VII T cell stimulating activity and thus comprising at least one T cell epitope as determined by T cell biology techniques is modified by addition or deletion of amino acid residues at either the amino or carboxy terminus of the peptide and tested to determine a change in {HEAD ~ T cell reactivity} to {TAIL ~ the modified peptide} 
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In order to determine precise T cell epitopes by , for example , fine mapping techniques , a peptide having Der p VII or Der f VII T cell stimulating activity and thus comprising at least one T cell epitope as determined by T cell biology techniques is modified by addition or deletion of amino acid residues at either the amino or carboxy terminus of the peptide and tested to determine a change in { HEAD ~ T cell reactivity } to { TAIL ~ the modified peptide }
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