Conditions resulting in an acquired loss of {HEAD ~ B cell function} that may be ameliorated or treated by administering the polypeptides, {TAIL ~ antibodies}, polynucleotides and agonists or antagonists thereof, include, but are not limited to, HIV Infection, AIDS, bone marrow transplant, and B cell chronic lymphocytic leukemia  
Conditions resulting in an acquired loss of { HEAD ~ B cell function } that may be ameliorated or treated by administering the polypeptides , { TAIL ~ antibodies } , polynucleotides and agonists or antagonists thereof , include , but are not limited to , HIV Infection , AIDS , bone marrow transplant , and B cell chronic lymphocytic leukemia
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