In one aspect, the invention provides a method for screening a compound that increases spine/excitatory synapse formation and numbers, the method comprising contacting Ephexin5 with a test compound and selecting {HEAD ~ the compound} that inhibits {TAIL ~ Rho GEF activity} of Ephexin5 
inhibits
In one aspect , the invention provides a method for screening a compound that increases spine / excitatory synapse formation and numbers , the method comprising contacting Ephexin5 with a test compound and selecting { HEAD ~ the compound } that inhibits { TAIL ~ Rho GEF activity } of Ephexin5
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD OTH REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH