Also provided are methods to identify compositions capable of treating cholesterol related disease states, comprising a. contacting a test composition with Na/K ATPase; and b. identifying if step a. results in antagonizing the ability of {HEAD ~ cholesterol} to bind to {TAIL ~ the CRAC domain} of the α1 subunit of Na/K ATPase 
to bind to
Also provided are methods to identify compositions capable of treating cholesterol related disease states , comprising a. contacting a test composition with Na / K ATPase ; and b. identifying if step a. results in antagonizing the ability of { HEAD ~ cholesterol } to bind to { TAIL ~ the CRAC domain } of the α1 subunit of Na / K ATPase
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