This invention provides C 22 substituted {TAIL ~ rapamycin derivatives} of the following formulas: ##STR1## and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, {HEAD ~ fungal infections}, adult T cell leukemia/lymphomas and hyperproliferative vascular disorders 
This invention provides C 22 substituted { TAIL ~ rapamycin derivatives } of the following formulas : # # STR1 # # and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection , host vs. graft disease , autoimmune diseases , diseases of inflammation , solid tumors , { HEAD ~ fungal infections } , adult T cell leukemia / lymphomas and hyperproliferative vascular disorders
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