In {TAIL ~ one aspect}, {HEAD ~ the invention} provides a method for screening a compound that increases spine/excitatory synapse formation and numbers, the method comprising contacting Ephexin5 with a test compound and selecting the compound that inhibits Rho GEF activity of Ephexin5 
In
In { TAIL ~ one aspect } , { HEAD ~ the invention } provides a method for screening a compound that increases spine / excitatory synapse formation and numbers , the method comprising contacting Ephexin5 with a test compound and selecting the compound that inhibits Rho GEF activity of Ephexin5
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