The nucleic acid sequences provided herein are useful in, for example, identifying and isolating {HEAD ~ functional homologs} of AE5′ and AE3′, and amplifying at least a portion of AE5′ and AE3′. Importantly, the nucleic acid sequences of the invention are also useful in age related expression and liver specific expression of a nucleotide sequence of interest in an animal, in gene therapy, and in reducing {TAIL ~ expression} of factor IX in an animal 
The nucleic acid sequences provided herein are useful in , for example , identifying and isolating { HEAD ~ functional homologs } of AE5′ and AE3′ , and amplifying at least a portion of AE5′ and AE3′. Importantly , the nucleic acid sequences of the invention are also useful in age related expression and liver specific expression of a nucleotide sequence of interest in an animal , in gene therapy , and in reducing { TAIL ~ expression } of factor IX in an animal
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