IRS1 and IRS2 are {HEAD ~ part} of the insulin or {TAIL ~ insulin} like growth factor signaling pathways, but also mediate some signals through other growth factors and cytokines, including IFNγ, IL2, IL4, IL7, IL9, IL13 or IL15, growth hormone, prolactin, or leptin 
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IRS1 and IRS2 are { HEAD ~ part } of the insulin or { TAIL ~ insulin } like growth factor signaling pathways , but also mediate some signals through other growth factors and cytokines , including IFNγ , IL2 , IL4 , IL7 , IL9 , IL13 or IL15 , growth hormone , prolactin , or leptin
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