Medrogestone, prepared in accordance with this invention, does contain an identifiable amount of 6 methylene 17α methylpregn 4 ene 3,20 dione which is readily removed by reaction of the impurity with maleic anhydride to produce {HEAD ~ the Diels Alder adduct} which can then be hydrolyzed in the presence of a base to afford the dibasic acid salt that is easily removed from the desired product by {TAIL ~ aqueous extraction} 
Medrogestone , prepared in accordance with this invention , does contain an identifiable amount of 6 methylene 17α methylpregn 4 ene 3,20 dione which is readily removed by reaction of the impurity with maleic anhydride to produce { HEAD ~ the Diels Alder adduct } which can then be hydrolyzed in the presence of a base to afford the dibasic acid salt that is easily removed from the desired product by { TAIL ~ aqueous extraction }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL