The method 1, wherein said tropic acid or topically effective salt thereof is applied periodically for a period of time sufficient to achieve {HEAD ~ at least a clinically discernable reduction} of {TAIL ~ said wrinkle} 
of
The method 1 , wherein said tropic acid or topically effective salt thereof is applied periodically for a period of time sufficient to achieve { HEAD ~ at least a clinically discernable reduction } of { TAIL ~ said wrinkle }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL