The method 1, wherein said tropic acid or topically effective salt thereof is applied periodically for a period of {HEAD ~ time} sufficient to achieve {TAIL ~ at least a clinically discernable reduction} of said wrinkle 
sufficient to achieve
The method 1 , wherein said tropic acid or topically effective salt thereof is applied periodically for a period of { HEAD ~ time } sufficient to achieve { TAIL ~ at least a clinically discernable reduction } of said wrinkle
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD REL REL REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH