In other examples of the invention, {HEAD ~ the shRNA} is shTOPK 3 having {TAIL ~ a sequence} as set forth in SEQ ID NO:3 or shTOPK 4 having a sequence as set forth in SEQ ID NO:4 
In other examples of the invention , { HEAD ~ the shRNA } is shTOPK 3 having { TAIL ~ a sequence } as set forth in SEQ ID NO:3 or shTOPK 4 having a sequence as set forth in SEQ ID NO:4
OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH