Methods of diagnosing whether an epithelial tissue is {HEAD ~ an abnormal tissue} by determining an expression pattern for PML in the epithelial tissue; determining {TAIL ~ an expression pattern} for nuclear bodies in the epithelial tissue; determining SUMO 1 colocalization and comparing the expression pattern for PML and the expression pattern for nuclear bodies with a control are disclosed 
by determining
Methods of diagnosing whether an epithelial tissue is { HEAD ~ an abnormal tissue } by determining an expression pattern for PML in the epithelial tissue ; determining { TAIL ~ an expression pattern } for nuclear bodies in the epithelial tissue ; determining SUMO 1 colocalization and comparing the expression pattern for PML and the expression pattern for nuclear bodies with a control are disclosed
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