In one embodiment, the invention provides a non naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and H2 to acetyl coenzyme A , methyl tetrahydrofolate or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and {TAIL ~ H2} to acetyl CoA or methyl THF in {HEAD ~ the absence} of the one or more exogenous proteins 
In one embodiment , the invention provides a non naturally occurring microorganism , comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO , CO2 and H2 to acetyl coenzyme A , methyl tetrahydrofolate or other desired products , wherein the microorganism lacks the ability to convert CO or CO2 and { TAIL ~ H2 } to acetyl CoA or methyl THF in { HEAD ~ the absence } of the one or more exogenous proteins
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