Through {HEAD ~ the use} of neutral organic solvents to inactivate endogenous enzyme activities , {TAIL ~ multiplexed extraction conditions} and combinatorial alterations in matrix stereoelectronic composition and analyte interactions, multiple suites of metabolites were directly ionized and quantitated directly from biologic extracts without the need for prior chromatographic separation 
to inactivate
Through { HEAD ~ the use } of neutral organic solvents to inactivate endogenous enzyme activities , { TAIL ~ multiplexed extraction conditions } and combinatorial alterations in matrix stereoelectronic composition and analyte interactions , multiple suites of metabolites were directly ionized and quantitated directly from biologic extracts without the need for prior chromatographic separation
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