A method of removing a non native nucleotide sequence from a target nucleic acid sequence comprising contacting the target {HEAD ~ nucleic acid sequence} with {TAIL ~ a modified trans excision splicing Group} 
with
A method of removing a non native nucleotide sequence from a target nucleic acid sequence comprising contacting the target { HEAD ~ nucleic acid sequence } with { TAIL ~ a modified trans excision splicing Group }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL