IRS1 and IRS2 are part of the insulin or insulin like {HEAD ~ growth factor} signaling {TAIL ~ pathways}, but also mediate some signals through other growth factors and cytokines, including IFNγ, IL2, IL4, IL7, IL9, IL13 or IL15, growth hormone, prolactin, or leptin 
signaling
IRS1 and IRS2 are part of the insulin or insulin like { HEAD ~ growth factor } signaling { TAIL ~ pathways } , but also mediate some signals through other growth factors and cytokines , including IFNγ , IL2 , IL4 , IL7 , IL9 , IL13 or IL15 , growth hormone , prolactin , or leptin
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