{HEAD ~ Concentrates} of one of the coagulation factors II, V and {TAIL ~ VIII} or a mixture thereof or blood plasma free from one or more of the coagulation factors VII, IX, X, XI and XII can be prepared by adding a reducing substance comprised of dithiothreitol, dithioerythritol, lipoic acid, mercaptoethanol, or a borohydride to blood or plasma, dithiothreitol being preferred 
of
{ HEAD ~ Concentrates } of one of the coagulation factors II , V and { TAIL ~ VIII } or a mixture thereof or blood plasma free from one or more of the coagulation factors VII , IX , X , XI and XII can be prepared by adding a reducing substance comprised of dithiothreitol , dithioerythritol , lipoic acid , mercaptoethanol , or a borohydride to blood or plasma , dithiothreitol being preferred
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