A gas is introduced to controllably generate {TAIL ~ bubbles} that reduce the density of the cell debris and create a buoyant flocculent phase that can be readily separated from, and thus provide, a substantially clarified fluid lysate phase that is enriched in extrachromosomal DNA but substantially depleted of {HEAD ~ cellular proteins} and chromosomal DNA 
A gas is introduced to controllably generate { TAIL ~ bubbles } that reduce the density of the cell debris and create a buoyant flocculent phase that can be readily separated from , and thus provide , a substantially clarified fluid lysate phase that is enriched in extrachromosomal DNA but substantially depleted of { HEAD ~ cellular proteins } and chromosomal DNA
OTH OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH