Such dosages will be administered to {HEAD ~ a subject} in {TAIL ~ need} of treatment from once to about three times each day, or more often as needed to effectively treat the problem 
in
Such dosages will be administered to { HEAD ~ a subject } in { TAIL ~ need } of treatment from once to about three times each day , or more often as needed to effectively treat the problem
OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH