The invention also relates to the use of any of the compounds described herein in the preparation of {HEAD ~ a medicament} for treating: hot flashes, {TAIL ~ vaginal dryness}, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, a degenerative brain disorder, cardiovascular disease, cerebrovascular disease breast cancer, endometrial cancer, cervical cancer, prostate cancer, benign prostatic hyperplasia, endometriosis, uterine fibroids, osteoarthritis and for contraception in a subject in need thereof 
for treating
The invention also relates to the use of any of the compounds described herein in the preparation of { HEAD ~ a medicament } for treating : hot flashes , { TAIL ~ vaginal dryness } , osteopenia , osteoporosis , hyperlipidemia , loss of cognitive function , a degenerative brain disorder , cardiovascular disease , cerebrovascular disease breast cancer , endometrial cancer , cervical cancer , prostate cancer , benign prostatic hyperplasia , endometriosis , uterine fibroids , osteoarthritis and for contraception in a subject in need thereof
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL REL OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH