{HEAD ~ Therapeutic efficacy} and toxicity may be determined by {TAIL ~ standard pharmaceutical procedures} in cell cultures or experimental animals, e.g., ED50 and LD50  
determined by
{ HEAD ~ Therapeutic efficacy } and toxicity may be determined by { TAIL ~ standard pharmaceutical procedures } in cell cultures or experimental animals , e.g. , ED50 and LD50
HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH REL REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH