{HEAD ~ Known sequences} can be used in {TAIL ~ the method} of the present invention for the sequences that encode the antibody heavy chain and light chain for introduction of mutation 
used in
{ HEAD ~ Known sequences } can be used in { TAIL ~ the method } of the present invention for the sequences that encode the antibody heavy chain and light chain for introduction of mutation
HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH REL REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH