{TAIL ~ The invention} comprises a low temperature method for the in situ derivatization and coupling of thermally and hydrolytically labile organic compounds such as spectinomycin to {HEAD ~ immunogenic carrier substances} 
{ TAIL ~ The invention } comprises a low temperature method for the in situ derivatization and coupling of thermally and hydrolytically labile organic compounds such as spectinomycin to { HEAD ~ immunogenic carrier substances }
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