{HEAD ~ The method} 1, wherein said tropic acid or topically effective salt thereof is applied periodically for a period of time sufficient to achieve {TAIL ~ at least a clinically discernable reduction} of said wrinkle 
{ HEAD ~ The method } 1 , wherein said tropic acid or topically effective salt thereof is applied periodically for a period of time sufficient to achieve { TAIL ~ at least a clinically discernable reduction } of said wrinkle
HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH