Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin 10 , wherein said antibody or fragment thereof: binds to the same region of IL 10 as the IL 10 receptor α and is not capable of binding IL 10 when the IL 10 is bound to the IL 10 receptor; and binds to IL 10 in homodimeric form by binding {HEAD ~ a discontinuous epitope} comprising residues of {TAIL ~ both monomers} 
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin 10 , wherein said antibody or fragment thereof : binds to the same region of IL 10 as the IL 10 receptor α and is not capable of binding IL 10 when the IL 10 is bound to the IL 10 receptor ; and binds to IL 10 in homodimeric form by binding { HEAD ~ a discontinuous epitope } comprising residues of { TAIL ~ both monomers }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL