{HEAD ~ Such asynchrony} can, in some patients, lead to ineffective ventilation and may increase {TAIL ~ the work} of breathing 
increase
{ HEAD ~ Such asynchrony } can , in some patients , lead to ineffective ventilation and may increase { TAIL ~ the work } of breathing
HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH