The determination of {HEAD ~ an effective dose} is well within {TAIL ~ the capability} of those skilled in the art 
The determination of { HEAD ~ an effective dose } is well within { TAIL ~ the capability } of those skilled in the art
OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH