It is to be understood, however, that the observation that a particular mutation or pattern of {HEAD ~ mutations} leads to {TAIL ~ changes} in a given property in no way excludes the possibility that the mutation in question can also influence other properties 
leads to
It is to be understood , however , that the observation that a particular mutation or pattern of { HEAD ~ mutations } leads to { TAIL ~ changes } in a given property in no way excludes the possibility that the mutation in question can also influence other properties
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD REL REL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH