In other examples of the invention, the shRNA is {HEAD ~ shTOPK} 3 having {TAIL ~ a sequence} as set forth in SEQ ID NO:3 or shTOPK 4 having a sequence as set forth in SEQ ID NO:4 
having
In other examples of the invention , the shRNA is { HEAD ~ shTOPK } 3 having { TAIL ~ a sequence } as set forth in SEQ ID NO:3 or shTOPK 4 having a sequence as set forth in SEQ ID NO:4
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD OTH REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH