The methods and formulations comprise modified release elements, providing for {HEAD ~ drug delivery} to {TAIL ~ the affected or desired area} 
to
The methods and formulations comprise modified release elements , providing for { HEAD ~ drug delivery } to { TAIL ~ the affected or desired area }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL