To cut such samples by the use of tools, such as scissors, would crush the delicate cell structure to such an extent that {HEAD ~ a detailed examination} of {TAIL ~ the exposed sheet edge} would not be meaningful 
of
To cut such samples by the use of tools , such as scissors , would crush the delicate cell structure to such an extent that { HEAD ~ a detailed examination } of { TAIL ~ the exposed sheet edge } would not be meaningful
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH