The system and {HEAD ~ method} may include {TAIL ~ a centralized secure database} with information on clinical research trial participants, clinical research trial events, investigator and administrator inputs, and communication of participants, investigators and administrators 
include
The system and { HEAD ~ method } may include { TAIL ~ a centralized secure database } with information on clinical research trial participants , clinical research trial events , investigator and administrator inputs , and communication of participants , investigators and administrators
OTH OTH OTH HEAD HEAD HEAD HEAD HEAD OTH REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH