This property has been exploited for, among other purposes, designing {HEAD ~ trans splicing ribozymes} that can replace {TAIL ~ the 3′ end} of mutant transcripts with corrected versions (Sullenger, B. A. & Cech, T. R. Nature 371, 619 6; Lan, N., Howrey, R. P., Lee, S. W., Smith, C. A., & Sullenger, B. A. Science 280, 1593 1596) 
replace
This property has been exploited for , among other purposes , designing { HEAD ~ trans splicing ribozymes } that can replace { TAIL ~ the 3′ end } of mutant transcripts with corrected versions ( Sullenger , B. A. & Cech , T. R. Nature 371 , 619 6 ; Lan , N. , Howrey , R. P. , Lee , S. W. , Smith , C. A. , & Sullenger , B. A. Science 280 , 1593 1596 )
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH