An object of the invention is to provide a method for the treatment and prevention of bacterial infection caused by {HEAD ~ Enterobacteriaceae family} in central nervous system and peripheral blood circulation in a mammal, which comprises administering to said mammal an effective amount of {TAIL ~ an outer membrane protein} A from Enterobacteriaceae family 
An object of the invention is to provide a method for the treatment and prevention of bacterial infection caused by { HEAD ~ Enterobacteriaceae family } in central nervous system and peripheral blood circulation in a mammal , which comprises administering to said mammal an effective amount of { TAIL ~ an outer membrane protein } A from Enterobacteriaceae family
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