Through the use of neutral organic solvents to inactivate endogenous enzyme activities , multiplexed extraction conditions and combinatorial alterations in matrix stereoelectronic composition and analyte interactions, multiple suites of metabolites were directly ionized and quantitated directly from biologic extracts without {HEAD ~ the need} for {TAIL ~ prior chromatographic separation} 
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Through the use of neutral organic solvents to inactivate endogenous enzyme activities , multiplexed extraction conditions and combinatorial alterations in matrix stereoelectronic composition and analyte interactions , multiple suites of metabolites were directly ionized and quantitated directly from biologic extracts without { HEAD ~ the need } for { TAIL ~ prior chromatographic separation }
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