The methods and formulations comprise {HEAD ~ modified release elements}, providing for {TAIL ~ drug delivery} to the affected or desired area 
providing for
The methods and formulations comprise { HEAD ~ modified release elements } , providing for { TAIL ~ drug delivery } to the affected or desired area
OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH REL REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH