I: ##STR14## or a salt, hydrate or solvate thereof, wherein A represents H, halo, or methyl, and B represents CH3, CH2 F, CHF2 or {HEAD ~ CF3}, comprising reacting {TAIL ~ a compound} of formula II: ##STR15## with a compound of formula III: ##STR16## or a salt or hydrate thereof, in an amide solvent at a controlled temperature to produce a compound of formula I 
I : # # STR14 # # or a salt , hydrate or solvate thereof , wherein A represents H , halo , or methyl , and B represents CH3 , CH2 F , CHF2 or { HEAD ~ CF3 } , comprising reacting { TAIL ~ a compound } of formula II : # # STR15 # # with a compound of formula III : # # STR16 # # or a salt or hydrate thereof , in an amide solvent at a controlled temperature to produce a compound of formula I
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