This invention provides C 22 substituted rapamycin derivatives of the following formulas: ##STR1## and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection, host vs. graft disease, autoimmune diseases, {HEAD ~ diseases} of inflammation, solid tumors, fungal infections, adult T cell leukemia/lymphomas and {TAIL ~ hyperproliferative vascular disorders} 
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This invention provides C 22 substituted rapamycin derivatives of the following formulas : # # STR1 # # and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection , host vs. graft disease , autoimmune diseases , { HEAD ~ diseases } of inflammation , solid tumors , fungal infections , adult T cell leukemia / lymphomas and { TAIL ~ hyperproliferative vascular disorders }
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