The reaction step can be conducted in the presence of {HEAD ~ an organic solvent} and {TAIL ~ a base} 
The reaction step can be conducted in the presence of { HEAD ~ an organic solvent } and { TAIL ~ a base }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH TAIL TAIL TAIL TAIL TAIL TAIL