A method of treating a patient suffering from a mitochondrial disease, said method comprising administering to said patient a pharmaceutical composition comprising {HEAD ~ an individual fumaric acid derivative} or {TAIL ~ a mixture} of fumaric acid derivatives, wherein said or is selected from the group consisting of 
A method of treating a patient suffering from a mitochondrial disease , said method comprising administering to said patient a pharmaceutical composition comprising { HEAD ~ an individual fumaric acid derivative } or { TAIL ~ a mixture } of fumaric acid derivatives , wherein said or is selected from the group consisting of
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH