Conservative substitutions include for example, {HEAD ~ replacement} of {TAIL ~ glycine} for alanine, valine for isoleucine, leucine for isoleucine, aspartic acid for glutamic acid, lysine for arginine, asparagine for glutamine, phenylalanine for tryptophan, and tryptophan for tyrosine 
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Conservative substitutions include for example , { HEAD ~ replacement } of { TAIL ~ glycine } for alanine , valine for isoleucine , leucine for isoleucine , aspartic acid for glutamic acid , lysine for arginine , asparagine for glutamine , phenylalanine for tryptophan , and tryptophan for tyrosine
OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH