{TAIL ~ Concentrates} of one of the coagulation factors II, V and VIII or a mixture thereof or blood plasma free from one or more of the coagulation factors VII, IX, X, XI and XII can be prepared by adding a reducing substance comprised of dithiothreitol, dithioerythritol, {HEAD ~ lipoic acid}, mercaptoethanol, or a borohydride to blood or plasma, dithiothreitol being preferred 
{ TAIL ~ Concentrates } of one of the coagulation factors II , V and VIII or a mixture thereof or blood plasma free from one or more of the coagulation factors VII , IX , X , XI and XII can be prepared by adding a reducing substance comprised of dithiothreitol , dithioerythritol , { HEAD ~ lipoic acid } , mercaptoethanol , or a borohydride to blood or plasma , dithiothreitol being preferred
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