Since IRS2 expression is modulated in part by cAMP levels in some cells, many current drugs may exert some of {HEAD ~ their effects} by functioning through {TAIL ~ the upregulation} of IRS2 
by functioning through
Since IRS2 expression is modulated in part by cAMP levels in some cells , many current drugs may exert some of { HEAD ~ their effects } by functioning through { TAIL ~ the upregulation } of IRS2
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD REL REL REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH