The method 1 wherein the anti diabetic agent is selected from the group consisting of {TAIL ~ a sulfonylurea}, a meglitinide, an agents which modify insulin secretion, a biguanide, a thiazolidinedione, a peroxisome proliferator activated receptor gamma agonist , a Retinoid X receptor modulator, an insulin sensitizing agent, an alpha glucosidase inhibitor, {HEAD ~ an insulin}, a small molecule mimics of insulin, 
The method 1 wherein the anti diabetic agent is selected from the group consisting of { TAIL ~ a sulfonylurea } , a meglitinide , an agents which modify insulin secretion , a biguanide , a thiazolidinedione , a peroxisome proliferator activated receptor gamma agonist , a Retinoid X receptor modulator , an insulin sensitizing agent , an alpha glucosidase inhibitor , { HEAD ~ an insulin } , a small molecule mimics of insulin ,
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH OTH OTH