Therapeutic efficacy and toxicity may be determined by {HEAD ~ standard pharmaceutical procedures} in {TAIL ~ cell cultures} or experimental animals, e.g., ED50 and LD50  
in
Therapeutic efficacy and toxicity may be determined by { HEAD ~ standard pharmaceutical procedures } in { TAIL ~ cell cultures } or experimental animals , e.g. , ED50 and LD50
OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH