{HEAD ~ Some} of the effects of certain known drugs may be dependent upon {TAIL ~ their ability} to upregulate IRS2 
dependent upon
{ HEAD ~ Some } of the effects of certain known drugs may be dependent upon { TAIL ~ their ability } to upregulate IRS2
HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH OTH OTH OTH REL REL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH