A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier or adjuvant and an effective TNF α release inhibiting amount of a substituted 2,4 imidazolidinedione compound corresponding to the formula I ##STR24## wherein {HEAD ~ R1} represents {TAIL ~ C1} 6 alkyl or C3 6 cycloalkyl 
represents
A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier or adjuvant and an effective TNF α release inhibiting amount of a substituted 2,4 imidazolidinedione compound corresponding to the formula I # # STR24 # # wherein { HEAD ~ R1 } represents { TAIL ~ C1 } 6 alkyl or C3 6 cycloalkyl
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