The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of {HEAD ~ ordered spatial arrangements} of {TAIL ~ differentiated tissues} in vertebrates 
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The present invention concerns the discovery that proteins encoded by a family of vertebrate genes , termed here hedgehog related genes , comprise morphogenic signals produced by embryonic patterning centers , and are involved in the formation of { HEAD ~ ordered spatial arrangements } of { TAIL ~ differentiated tissues } in vertebrates
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