The compounds of the invention are useful in the treatment of {TAIL ~ disorders} associated with the depletion of {HEAD ~ estrogen} such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist 
The compounds of the invention are useful in the treatment of { TAIL ~ disorders } associated with the depletion of { HEAD ~ estrogen } such as hot flashes , vaginal dryness , osteopenia and osteoporosis ; hormone sensitive cancers and hyperplasia of the breast , endometrium , cervix and prostate ; endometriosis , uterine fibroids , osteoarthritis and as contraceptive agents , alone or in combination with a progestogen or progestogen antagonist
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