Another aspect of the disclosure encompasses therapeutic compositions comprising at least one of the 4 quinolone compounds of the disclosure and in an amount that is effective, when administered to an animal or human subject as a single dose or as {TAIL ~ a series} of doses, in reducing or eliminating a malarial parasite infection in {HEAD ~ the subject animal} or human, or prophylactically prevents the establishment of such an infection 
Another aspect of the disclosure encompasses therapeutic compositions comprising at least one of the 4 quinolone compounds of the disclosure and in an amount that is effective , when administered to an animal or human subject as a single dose or as { TAIL ~ a series } of doses , in reducing or eliminating a malarial parasite infection in { HEAD ~ the subject animal } or human , or prophylactically prevents the establishment of such an infection
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