{HEAD ~ Another aspect} of the disclosure encompasses {TAIL ~ therapeutic compositions} comprising at least one of the 4 quinolone compounds of the disclosure and in an amount that is effective, when administered to an animal or human subject as a single dose or as a series of doses, in reducing or eliminating a malarial parasite infection in the subject animal or human, or prophylactically prevents the establishment of such an infection 
{ HEAD ~ Another aspect } of the disclosure encompasses { TAIL ~ therapeutic compositions } comprising at least one of the 4 quinolone compounds of the disclosure and in an amount that is effective , when administered to an animal or human subject as a single dose or as a series of doses , in reducing or eliminating a malarial parasite infection in the subject animal or human , or prophylactically prevents the establishment of such an infection
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