This invention provides C 22 substituted {HEAD ~ rapamycin derivatives} of the following formulas: ##STR1## and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, {TAIL ~ solid tumors}, fungal infections, adult T cell leukemia/lymphomas and hyperproliferative vascular disorders 
This invention provides C 22 substituted { HEAD ~ rapamycin derivatives } of the following formulas : # # STR1 # # and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection , host vs. graft disease , autoimmune diseases , diseases of inflammation , { TAIL ~ solid tumors } , fungal infections , adult T cell leukemia / lymphomas and hyperproliferative vascular disorders
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