Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using {TAIL ~ flotation} to separate and eliminate {HEAD ~ undesired insoluble cellular debris} including chromosomal DNA from the lysates 
Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using { TAIL ~ flotation } to separate and eliminate { HEAD ~ undesired insoluble cellular debris } including chromosomal DNA from the lysates
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