I: ##STR14## or a salt, hydrate or solvate thereof, wherein A represents H, halo, or methyl, and B represents CH3, CH2 F, CHF2 or CF3, comprising reacting a compound of formula II: ##STR15## with {HEAD ~ a compound} of {TAIL ~ formula III}: ##STR16## or a salt or hydrate thereof, in an amide solvent at a controlled temperature to produce a compound of formula I 
I : # # STR14 # # or a salt , hydrate or solvate thereof , wherein A represents H , halo , or methyl , and B represents CH3 , CH2 F , CHF2 or CF3 , comprising reacting a compound of formula II : # # STR15 # # with { HEAD ~ a compound } of { TAIL ~ formula III } : # # STR16 # # or a salt or hydrate thereof , in an amide solvent at a controlled temperature to produce a compound of formula I
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