Conservative substitutions include for example, replacement of glycine for alanine, valine for isoleucine, leucine for isoleucine, aspartic acid for glutamic acid, lysine for arginine, asparagine for glutamine, phenylalanine for tryptophan, and {HEAD ~ tryptophan} for {TAIL ~ tyrosine} 
Conservative substitutions include for example , replacement of glycine for alanine , valine for isoleucine , leucine for isoleucine , aspartic acid for glutamic acid , lysine for arginine , asparagine for glutamine , phenylalanine for tryptophan , and { HEAD ~ tryptophan } for { TAIL ~ tyrosine }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL