A chemically modified membrane is positioned between a first template having a first set of holes and a second set of holes aligned with the first set of holes to define {HEAD ~ a plurality} of {TAIL ~ exposed portions} of the membrane in such as manner as to prevent collapse of pores in the membrane during application of a differential pressure across the membrane 
A chemically modified membrane is positioned between a first template having a first set of holes and a second set of holes aligned with the first set of holes to define { HEAD ~ a plurality } of { TAIL ~ exposed portions } of the membrane in such as manner as to prevent collapse of pores in the membrane during application of a differential pressure across the membrane
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