In some embodiments, the abnormal tissue is poorly differentiated cervical squamous cell carcinoma which exhibits downregulated PML expression; about 5 nuclear bodies in the epithelial tissue; nuclear bodies having an area of about 0.37 μm2; about 10% of {HEAD ~ the nuclear bodies} comprising {TAIL ~ PML} colocalize with SUMO 1; or a combination thereof 
In some embodiments , the abnormal tissue is poorly differentiated cervical squamous cell carcinoma which exhibits downregulated PML expression ; about 5 nuclear bodies in the epithelial tissue ; nuclear bodies having an area of about 0.37 μm2 ; about 10 % of { HEAD ~ the nuclear bodies } comprising { TAIL ~ PML } colocalize with SUMO 1 ; or a combination thereof
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