Either of the aforementioned transgenic non human animals can be bred with animals having inactivated {TAIL ~ heavy and light chain loci} to produce a transgenic non human animal that produces a fully human antibody and is incapable of producing {HEAD ~ an endogenous antibody} 
Either of the aforementioned transgenic non human animals can be bred with animals having inactivated { TAIL ~ heavy and light chain loci } to produce a transgenic non human animal that produces a fully human antibody and is incapable of producing { HEAD ~ an endogenous antibody }
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