The methods involve the use of {TAIL ~ several sequential steps}, including {HEAD ~ the use} of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification 
The methods involve the use of { TAIL ~ several sequential steps } , including { HEAD ~ the use } of matrices that bind molecules bearing negative charges , matrices that bind molecules bearing positive charges , intermediate selectivity matrices , methods that separate molecules based on their size , shape , or buoyant density , and by affinity purification
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