Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin 10 , wherein said antibody or fragment thereof: binds to the same region of IL 10 as the IL 10 receptor α and is not capable of binding IL 10 when the IL 10 is bound to the IL 10 receptor; and binds to {HEAD ~ IL} 10 in {TAIL ~ homodimeric form} by binding a discontinuous epitope comprising residues of both monomers 
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin 10 , wherein said antibody or fragment thereof : binds to the same region of IL 10 as the IL 10 receptor α and is not capable of binding IL 10 when the IL 10 is bound to the IL 10 receptor ; and binds to { HEAD ~ IL } 10 in { TAIL ~ homodimeric form } by binding a discontinuous epitope comprising residues of both monomers
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