A method of determining whether a small molecule is an activator or an inhibitor of insulin receptor substrate 2 , wherein said activator or inhibitor binds to IRS2 or to a complex comprising IRS2 and an IRS2 binding protein and cannot bind to {HEAD ~ the non IRS2 proteins} in {TAIL ~ the absence} of IRS2, which comprises: 
A method of determining whether a small molecule is an activator or an inhibitor of insulin receptor substrate 2 , wherein said activator or inhibitor binds to IRS2 or to a complex comprising IRS2 and an IRS2 binding protein and can not bind to { HEAD ~ the non IRS2 proteins } in { TAIL ~ the absence } of IRS2 , which comprises :
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