In one aspect, the invention provides {HEAD ~ a method} for screening {TAIL ~ a compound} that increases spine/excitatory synapse formation and numbers, the method comprising contacting Ephexin5 with a test compound and selecting the compound that inhibits Rho GEF activity of Ephexin5 
In one aspect , the invention provides { HEAD ~ a method } for screening { TAIL ~ a compound } that increases spine / excitatory synapse formation and numbers , the method comprising contacting Ephexin5 with a test compound and selecting the compound that inhibits Rho GEF activity of Ephexin5
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