The compounds of the invention are useful in the treatment of {HEAD ~ disorders} associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and {TAIL ~ osteoporosis}; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist 
The compounds of the invention are useful in the treatment of { HEAD ~ disorders } associated with the depletion of estrogen such as hot flashes , vaginal dryness , osteopenia and { TAIL ~ osteoporosis } ; hormone sensitive cancers and hyperplasia of the breast , endometrium , cervix and prostate ; endometriosis , uterine fibroids , osteoarthritis and as contraceptive agents , alone or in combination with a progestogen or progestogen antagonist
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