In some specific embodiments, {HEAD ~ the C 3′ substituted anthracycline compounds} of the present invention have {TAIL ~ the general formula}: 
In some specific embodiments , { HEAD ~ the C 3′ substituted anthracycline compounds } of the present invention have { TAIL ~ the general formula } :
OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH REL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH