{HEAD ~ The present invention} overcomes {TAIL ~ a significant disadvantage} of the prior art, since prior methods could not constrain the formation or deposition of biomolecules to a small region, due to the inability to localize the synthesis process or to restrict the migration of materials to prevent adjacent “spots” from diffusing into each other 
{ HEAD ~ The present invention } overcomes { TAIL ~ a significant disadvantage } of the prior art , since prior methods could not constrain the formation or deposition of biomolecules to a small region , due to the inability to localize the synthesis process or to restrict the migration of materials to prevent adjacent “ spots ” from diffusing into each other
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