Yet more particularly, the exemplary age regulatory element 5′ has been discovered to regulate stable gene expression over time in vivo, while the exemplary age regulatory element 3′ has been discovered to regulate increased gene expression over {HEAD ~ time} in {TAIL ~ vivo} 
Yet more particularly , the exemplary age regulatory element 5′ has been discovered to regulate stable gene expression over time in vivo , while the exemplary age regulatory element 3′ has been discovered to regulate increased gene expression over { HEAD ~ time } in { TAIL ~ vivo }
OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD REL TAIL TAIL TAIL TAIL TAIL