In some aspects, provided is a composition for administration to an open wound in a subject, comprising a carrier, an active agent and a wound targeting moiety, wherein the wound targeting moiety facilitates {HEAD ~ local delivery} of {TAIL ~ the active agent} to wounded tissue by selectively binding to an exposed protein, peptide motif or epitope, wherein the exposed protein, peptide motif or epitope is exposed upon wounding of the subject 
In some aspects , provided is a composition for administration to an open wound in a subject , comprising a carrier , an active agent and a wound targeting moiety , wherein the wound targeting moiety facilitates { HEAD ~ local delivery } of { TAIL ~ the active agent } to wounded tissue by selectively binding to an exposed protein , peptide motif or epitope , wherein the exposed protein , peptide motif or epitope is exposed upon wounding of the subject
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