{HEAD ~ The method} 22, wherein the formulation is administered to {TAIL ~ the subject} once a day 
{ HEAD ~ The method } 22 , wherein the formulation is administered to { TAIL ~ the subject } once a day
HEAD HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH