In some embodiments, the present invention provides {HEAD ~ a method} of detecting or diagnosing CIN III in a subject comprising analyzing the PML pattern and NB size and shape in the epithelium of {TAIL ~ the subject} 
In some embodiments , the present invention provides { HEAD ~ a method } of detecting or diagnosing CIN III in a subject comprising analyzing the PML pattern and NB size and shape in the epithelium of { TAIL ~ the subject }
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