In {HEAD ~ a further embodiments}, the filtered clarified lysate is further purified by ion exchange chromatography to remove residual impurities including cellular proteins, chromosomal DNA, {TAIL ~ RNA} and endotoxins 
In { HEAD ~ a further embodiments } , the filtered clarified lysate is further purified by ion exchange chromatography to remove residual impurities including cellular proteins , chromosomal DNA , { TAIL ~ RNA } and endotoxins
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