A pharmaceutical composition comprising {TAIL ~ at least one pharmaceutically acceptable carrier} or adjuvant and an effective TNF α release inhibiting amount of a substituted 2,4 imidazolidinedione compound corresponding to the formula I ##STR24## wherein R1 represents {HEAD ~ C1} 6 alkyl or C3 6 cycloalkyl 
A pharmaceutical composition comprising { TAIL ~ at least one pharmaceutically acceptable carrier } or adjuvant and an effective TNF α release inhibiting amount of a substituted 2,4 imidazolidinedione compound corresponding to the formula I # # STR24 # # wherein R1 represents { HEAD ~ C1 } 6 alkyl or C3 6 cycloalkyl
OTH OTH OTH OTH TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL TAIL OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH OTH HEAD HEAD HEAD HEAD HEAD OTH OTH OTH OTH OTH OTH