intratumorally or systemically administering to the subject in need thereof an effective amount of a fusogenic mutant Herpes Simplex Virus Type 2 , wherein the fusogenic mutant HSV 2 comprises {HEAD ~ a modified ICP10 coding region} lacking {TAIL ~ nucleotides} 1 to 1204 of an endogenous ICP10 coding region, wherein said fusogenic mutant HSV 2 comprises the modified ICP10 operably linked to an endogenous or a constitutive promoter and expresses a modified ICP10 polypeptide that lacks protein kinase activity but retains ribonucleotide reductase activity, and 
intratumorally or systemically administering to the subject in need thereof an effective amount of a fusogenic mutant Herpes Simplex Virus Type 2 , wherein the fusogenic mutant HSV 2 comprises { HEAD ~ a modified ICP10 coding region } lacking { TAIL ~ nucleotides } 1 to 1204 of an endogenous ICP10 coding region , wherein said fusogenic mutant HSV 2 comprises the modified ICP10 operably linked to an endogenous or a constitutive promoter and expresses a modified ICP10 polypeptide that lacks protein kinase activity but retains ribonucleotide reductase activity , and
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