Does paternal alcohol exposure affect sperm cytosine methyltransferase messenger RNA levels?
Alcohol-induced reductions in cytosine methyltransferase mRNA levels may reflect altered genomic imprinting caused by reduced DNA methylation, which, in turn, may lead to the expression of normally silent paternal alleles and may be a mechanism for paternal alcohol effects.
APOE ε4 is associated with increased parietal lobe WMH.