Can magnetic resonance imaging replace single photon computed tomography and computed tomography in detecting bony invasion in patients with oral squamous cell carcinoma?
MRI is accurate in predicting bone involvement. The addition of SPECT and CT to routine MRI staging protocols seems no longer indicated. CT may be useful in some selected cases to determine maxillary involvement due to the thinner cortex of the maxilla.
These results suggest that two complementary outward forces are exerted on the prophase spindle by the overlying cortex. Specifically, dynein localized on the mechanically firm actin caps and the actomyosin-driven contraction of the deformable soft patches of the actin cortex, cooperate to pull astral microtubules outward. Thus, myosin II controls the size and dynamic properties of the actin-based cortex to influence the spacing of the poles of the underlying spindle during prophase.