Does neutrophil elastase inhibitor ( sivelestat ) reduce the levels of inflammatory mediators by inhibiting NF-kB?
Sivelestat may inhibit the various inflammatory mediators through NF-kB inhibition.
Analysis of RUNX3 gene promoter by quantitative pyrosequencing suggested methylation status of RUNX3 is different in normal and tumor tissues. RUNX3 methylation level is associated with GC, especially the methylation at site -1415 contributes to the poor prognosis in GC. Thus, RUNX3 methylation may serve as a valuable diagnostic and prognostic biomarker in GC.