Is intrachromosomal amplification of chromosome 21 associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children 's oncology group studies : a report from the children 's oncology group?
iAMP21 is associated with inferior outcome in pediatric B-ALL, particularly SR patients who require more intensive therapy and are now treated on HR COG ALL protocols.
Our data suggest that Cas III-ia induces cell death by autophagy and apoptosis, in part due to the activation of ROS -dependent JNK signaling. These findings support further studies of Cas III-ia as candidate for treatment of human malignant glioma.