Do intestinal epithelial cells mediate lung injury after ethanol exposure and hypoxic insult?
Gut-lung interactions after EtOH exposure and ischemia/reperfusion insults lead to lung injury and may potentiate the clinical evolution of acute respiratory distress syndrome. These in vitro findings confirm clinical experience and provide a model to further elucidate the pathogenic mechanisms.
This study found that a combined pharmacokinetic-dynamic model consisting of a two-compartmental model with a LAG time and presystemic compartments and a sigmoidal maximum possible drug effect model accurately described the early phase pharmacology of propofol during infusion rate between 10 and 160 mg . kg(-1). h(-1). The infusion rate has an influence on kinetics, but not dynamics. Age was a covariate for LAG time.