Is heart-rate complexity a surrogate measure of cardiac output before, during, and after hemorrhage in a conscious sheep model of multiple hemorrhages and resuscitation?
HRC has potential utility as a noninvasive tool for assessing the response of CO to life-threatening injuries such as hemorrhagic shock. However, further investigation and other animal models or human studies are needed.
These data demonstrate that baseline rsFC within the salience network is linked to clinical placebo responses. This information could be employed to identify patients who would benefit from lower doses of antidepressant medication or non-pharmacological approaches, or to develop biomarkers of placebo effects in clinical trials.