Does accumbens functional connectivity during reward mediate sensation-seeking and alcohol use in high-risk youth?
These results suggest preexisting differences in accumbens reward-related functional connectivity in high-risk subjects. NAcc coupling with SSMA, involved in attention and motor networks, and precuneus, a default mode structure, appear to mediate sensation-seeking's effect on drinking in those most at-risk. Differences in accumbens connectivity with attention/motor/default networks, rather than control systems, may influence the reward system's role in vulnerability for substance abuse.
Modifying BSH with HA is a promising strategy for enhancing the efficacy of BNCT for therapy of MPM.