Does an oral load of the early glycation compound lactuloselysine fail to accumulate in the serum of uraemic patients?
Dietary APs do not accumulate in the blood even in advanced renal failure. The amount of APs measured as furosine excreted in the urine is significantly less, however, in renal failure and CAPD patients compared with healthy subjects. Although the findings exclude accumulation of lactuloselysine in renal failure, they do not generally exclude accumulation of other food-derived advanced glycation end products (AGEs).
The emergence of cells primed to respond to OSM with increased Chi3L1 production appears to be associated with pathological processes active in SSc.