Does xenograft bone inclusion improve incorporation of hydroxyapatite cement into cancellous defects?
Adding xenograft to HAC creates a bioactive composite that is more rapidly incorporated, resorbed, and replaced by new bone. The presence of processed xenograft particles creates a vigorous inflammatory response, but there may be some benefit to the resorption rate of the HAC as a result of the infiltration of cells. Future research should focus on the longer-term incorporation and remodeling of XBC.
These results suggest that selectin inhibitors, including sialyl Lewis X oligosaccharide and PB1.3, may provide clinical benefits in the prevention of ARF associated with sepsis and MODS. To our knowledge, this is the first report that P-selectin is directly involved in lipopolysaccharide-induced ARF in rabbits.