Does restoration of epigenetically silenced SULF1 expression by 5-aza-2-deoxycytidine sensitize hepatocellular carcinoma cells to chemotherapy-induced apoptosis?
SULF1 gene silencing in HCC occurs through histone modifications on the 
These findings provide evidence that a high expression level of ADAM8 serves as a biomarker for poor prognosis for HCC. Thus, we speculate that ADAM8 may be a potential target of antiangiogenic therapy for HCC.