Estimation of glomerular filtration rate: does haemoglobin discriminate between ageing and true CKD?
An eGFR<60 ml/min/1.73 m(2) is very common in older people. Only an eGFR<45 ml/min/1.73 m(2) identified a smaller sub-group of older people with an increased prevalence of significant anaemia suggesting a clinically relevant disease. The benefits of identifying older people with an eGFR>or =45 ml/min/1.73 m(2) need to be determined.
These findings suggest that endogenous H2O2 contributes to endothelium-dependent arteriolar dilation in juvenile rats, but not in younger rats, and that H2O2 acts in juvenile rats by stimulating endothelial NO release and activating smooth muscle K+ channels.