Does the acidic microclimate in poly ( lactide-co-glycolide ) microspheres stabilize camptothecins?
PLGA microspheres prepared by the standard solvent evaporation techniques develop an acidic microclimate that stabilizes the lactone form of CPTs. This microclimate may be neutralized by co-encapsulating a base such as Mg(OH)2, as suggested by previous work with poly(ortho esters) (2).
Use of a CM catheter to ensure isolation of the PV antrum improved the success of CPVA but increased some procedural requirements.