Does glucocorticoid induction of occludin expression and endothelial barrier require transcription factor p54 NONO?
p54 is essential for GC-mediated expression of occludin, claudin-5, and barrier induction, and the p54/PSF heterodimer may contribute to normal blood-retinal barrier (BRB) induction in vivo. Understanding the mechanism of GC induction of BRB properties may provide novel therapies for macular edema.
This is the first large prospective report of a significant association between smoking and organ/space SSI in orthopaedic surgery with implants.