Does iL-1β promote stemness and invasiveness of colon cancer cells through Zeb1 activation?
Our findings indicate that IL-1β may promote colon tumor growth and invasion through activation of CSC self-renewal and EMT, and Zeb1 plays a critical role in these two processes. Thus, IL-1β and Zeb1 might be new therapeutic targets against colon cancer stem cells.
The maximum flow rate, PIP1 and BCI were significantly lower in patients who required CISC after BTX-A treatment than in those who did not. A PIP1 of<or =50 in women and a BCI of<or =120 might be predictive of a need for CISC in this setting, and might help when counselling patients.