Does specific adaptive humoral response against a gp41 motif inhibit CD4 T-cell sensitivity to NK lysis during HIV-1 infection?
These results strongly suggested that anti-3S antibodies might affect disease course in inhibiting NKp44L expression and CD4 sensitivity to NK lysis. In linking specific adaptive immunity to the innate immunity induced by the 3S motif, this study may have important implications for therapeutic vaccines against AIDS.
The VHL and HIF1A polymorphisms may not influence RCC susceptibility but may jointly influence RCC progression and survival.