Does the leucine-rich repeat-containing G protein-coupled receptor 8 gene T222P mutation cause cryptorchidism?
Our results suggest that the T222P mutation cannot be considered either causative or a susceptibility factor for cryptorchidism. A true causative mutation in the LGR8 gene still remains to be identified.
We have found a significant association between IL-1 RA allele distribution and FC and a poor correlation of T/C substitution at the -31 position of IL-1β promoter in FC. Further studies are needed to investigate the gene expression levels and polymorphic situation in same samples.