Does nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enable control of autoimmunity in mice?
Our findings provide proof of principle that the selective delivery of autoantigen peptides to LSECs by NPs can induce antigen-specific Tregs and enable effective treatment of autoimmune disease. These findings highlight the importance of Treg induction by LSECs for immune tolerance.
We believe a tension-free technique allows bilateral inguinal hernias to be repaired during one operation with similar outcomes as a unilateral tension-free repair and less cost than a sequential bilateral repair.