Does dingxin recipe ( ) prevent ischemia/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses?
DXR could alleviate I/R-induced arrhythmias, which might be related to increased expression of PHB. The enhanced expression of PHB prevented against the depletion of GSH and consequently inhibited apoptosis of cardiomyocytes. Furthermore, up-regulation of PHB might ameliorate I/R-induced cell death and leakage of hFABP by suppressing neutrophil infiltration and IL-6 expressions.
These results indicate that Ang II upregulates IL-1 beta-induced iNOS expression in cardiac myocytes, which is mediated at least partially via activation of protein kinase C.