Does zoledronic acid treatment impair protein geranyl-geranylation for biological effects in prostatic cells?
Although zoledronic acid is currently the most efficient bisphosphonate in metastatic prostate cancer management, its mechanism of action in prostatic cells remains unclear. We suggest in this work that although in first intention ZOL inhibits FPPsynthase its main biological actitivity is directed against protein Geranylgeranylation.
Giving consideration to patients additional symptoms and general condition before committing to a surgical method for RP may improve the success rate. Laparoscopic rectopexy should be considered as the first option in the treatment RP owing to its favorable early-term outcomes and acceptable rate of long-term recurrence.