Does simulation of multiple ion channel block provide improved early prediction of compounds ' clinical torsadogenic risk?
The suggested calculations improve the reliability of early cardiac safety assessments, beyond those based solely on a hERG block effect.
Transmembrane and cytoplasmic domains of MOG contain immunodominant T-cell epitopes in EAE. A CNS autoantigen can also contain nonpathogenic stimulatory T-cell epitopes. Recognition that a myelin antigen contains multiple encephalitogenic and nonencephalitogenic determinants may have implications for therapeutic development in MS.