Does guggulsterone suppress bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells?
Guggulsterone may be used as a novel drug to target CdX2 expression in certain gut adenocarcinomas.
The combination of gemcitabine and cisplatin is clearly an active regimen and may improve survival based on our 1-year and median survival findings and results from other institutions. However, only an adequately powered randomized controlled trial will assess any real survival benefit over single agent gemcitabine.