Is baroreceptor sensitivity impaired in elderly subjects with metabolic syndrome and insulin resistance?
Cardiovascular autonomic imbalance, measured as a reduced BRS, is present in metabolic syndrome and in subjects with insulin resistance. As BRS mainly reflects vagal activity, future prospective studies will address the possibility of vagal impairment in the pathogenesis of metabolic syndrome.
Using a population-based approach, we find that the incidence of NTM has continued to rise since the last national analysis. Overall, this represents an almost ten-fold increase since 1995. Pulmonary MAC in older individuals is responsible for the majority of this change. We are limited to reporting NTM isolates and not clinical disease caused by these organisms. To determine whether the burden of NTM disease is genuinely increasing, a standardised approach to the collection of linked national microbiological and clinical data is required.