Does accurate pathological staging of urothelial neoplasms require better cystoscopic sampling?
The well documented tendency toward cystoscopic under staging has not necessarily resulted in a high incidence of muscularis propria in bladder cases of urothelial neoplasms. Even when muscle may have been sampled, artifacts that were often due to thermocoagulation hampered accurate pathological staging.
The ability to utilize, reprocess and regenerate tissues deemed "unsuitable" for transplantation allows us to salvage valuable tissue. Reprocessing the tissue has the potential to have a considerable impact on addressing the problems associated with cadaveric donor shortage. Patients would directly benefit by accessing greater numbers of corneal grafts and health authorities would fulfill their responsibility for the delivery of effective corneal reconstruction to alleviate corneal blindness. However, in order to progress, we may need to take a step back to establish a "decellularization" criterion; which should balance effective removal of immune reactive material with maintenance of tissue functionality.