Does n-Acetyl L-Cysteine protect mouse ears from the effects of noise*?
There were no statistically significant differences in ABR threshold shifts between the mice receiving L-NAC and the control mice. This indicates that L-NAC was not effective in preventing permanent threshold shift in this mouse model of NIHL.
This pilot study suggests that transforming latent utilities to health utilities is feasible, and the study provides preliminary evidence that linear regression involving polynomial and logarithmic terms may be more desirable than nonparametric spline or LOESS functions.