Does ciglitazone mediate COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells?
Taken together, our findings suggest that ciglitazone is a negative modulator of COX-2/PGE2 in NSCLC.
We report for the first time that human AC have a marked antiproliferative effect on anti-CD3 stimulated PBMC, which is reduced upon culture in medium-inducing extensive cell de-differentiation. These results reflect the immunosuppressive properties observed for other different mesenchymal cell types and raise the question of a potential common physiological role in local tissue protection.