Does morphometric studies in human pancreatic cancer argue against the etiological role of type 2 diabetes in pancreatic cancer?
The morphometric data show a decrease rather than an increase in the number of IAPP-expressing cells in PC. Differences in abnormalities in type-2 diabetics and in zone B of PC tissue strongly argue against the role of type 2 diabetes in PC. Rather, the development of diabetes in subjects prone to pancreatic cancer could be a red flag for malignancy.
The study provides a ideal astrocyte model of pharmacoresistant epilepsy, which is induced by CL. The increased expressions of P-gp may involve in induction of the pharmacoresistance.