Does synergism of simvastatin with losartan prevent angiotensin II-induced cardiomyocyte apoptosis in vitro?
Our data provide the first evidence that synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro. Synergism between simvastatin and losartan may provide a new therapeutic approach to the prevention of cardiac remodelling.
These results demonstrate that the SMWE inhibits PAR2 agonist-induced mouse paw edema.