Is renoprotection provided by losartan in combination with pioglitazone superior to renoprotection provided by losartan alone in patients with type 2 diabetic nephropathy?
Renoprotection conferred by losartan combined with pioglitazone is superior to that conferred by losartan alone in subjects with type 2 diabetic nephropathy. The combination is generally well tolerated.
These findings suggest that the earliest endothelial changes occur in smaller arterioles and microvascular beds, but not in medium or macrovascular beds, in early diffuse SSc.