Do oncostatin M-Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin-Induced Pulmonary Fibrosis Through Paracrine Effects of the Hepatocyte Growth Factor?
In this study, the investigation of a cytokine, oncostatin M (OSM), has been extended. The results showed that OSM preconditioning of mesenchymal stem cells (MSCs) could lead to comprehensive modification of gene regulation that enhances cell proliferation and migration and attenuates extracellular matrix production. Hence, transplantation of OSM-preconditioned MSCs improved pulmonary functions and reduced inflammatory and fibrotic mediators in a bleomycin-induced pulmonary fibrosis mouse model. The data further suggest that the upregulation of hepatocyte growth factor plays a key role in mediating the therapeutic effects of transplanted OSM-preconditioned MSCs.
These data suggest the possibility of an association between history of typical migraine headache and OAG, which could be modified by age.