Does dichloroacetate restore drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation?
The abilityof DCA to target cells with mitochondrial respiratory defect and restore paclitaxel sensitivity by inducing citrate accumulation supports further preclinical development.
As2O3 treatment results in pronounced differences in trace elements between healthy and infected individuals. This finding is important to consider, regarding treatment safety and efficacy, when As2O3 therapy is used in the clinical setting.