Is brachyury , a driver of the epithelial-mesenchymal transition , overexpressed in human lung tumors : an opportunity for novel interventions against lung cancer?
We hypothesize that the elimination of Brachyury-positive tumor cells may be able to prevent and/or diminish tumor dissemination and the establishment of metastases. The ability of Brachyury-specific T-cell lines to lyse Brachyury-positive tumor cells, in vitro, supports the development of Brachyury-based immunotherapeutic approaches for the treatment of lung cancer.
Our data suggest that the PlA1/A2 polymorphism of GP IIIa is not associated with DVT.