Does induction of S100A4 in periodontal ligament cells enhance osteoclast formation?
Our results suggest that bone destruction in periodontitis might be associated with increased S100A4 expression in hPDL cells.
Mutations in genes with strong biological relevance to AVSD, including syndrome-associated genes, can contribute to AVSD, even in those with isolated heart disease. The identification of a gene set associated with AVSD will facilitate targeted genetic screening in this cohort.