Are igG antibodies against food antigens correlated with inflammation and intima media thickness in obese juveniles?
We show here, that obese children have significantly higher IgG antibody values directed against food antigens than normal weight children. Anti- food IgG antibodies are tightly associated with low grade systemic inflammation and with the IMT of the common carotid arteries. These findings raise the possibility, that anti-food IgG is pathogenetically involved in the development of obesity and atherosclerosis.
Although genetic variation accounts for a good part of this condition, the association between different polymorphisms and environmental factors has yet to be explained.