Does atrial fibrillation impair endothelial function of forearm vessels in humans?
These findings suggest that endothelium-dependent vasodilatation is impaired by AF and improves after sinus rhythm is restored.
Sites with high propensity to enroll patients in RCTs appear to have unobserved characteristics, which play a significant role in outcomes for non-RCT patients. For RCT participants in low-enrollment sites, possibly RCT protocols, which proscribe care delivery and monitoring, attenuate this effect. These results have implications for future research to improve outcomes in nonresearch care settings.