Does increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediate the antitumor effect of triptolide?
The potent induction of HIF-1α protein involved in its cytotoxicity, together with the suppression of HIF-1 transcriptional activity, indicates the great therapeutic potential of triptolide as an anticancer drug. Meanwhile, our data further stress the possibility that HIF-1α functions in an unresolved nature or condition.
Increased endogenous oxalate production may occur in patients receiving long-term TPN.