Are dimethyl sulphoxide and dimethyl sulphone potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2?
In this study, we demonstrate that both DMSO and DMS represent strong anti-inflammatory properties by blocking constitutive as well as IL-1β-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.
The clf1 mutation in A/WySn is a "metastable epiallele", in which stochastic deficiency in some individuals of DNA methylation of a retrotransposon uniquely inserted near the Wnt9b gene allows transcriptional activity of the retrotransposon and interference with transcription from Wnt9b. Methylation of metastable epialleles should be investigated in human nonsyndromic CL ± P.