Does the shear stress-induced transcription factor KLF2 affect dynamics and angiopoietin-2 content of Weibel-Palade bodies?
These data suggest that KLF2 expression leads to a change in size and composition of the regulated secretory compartment of endothelial cells and alters its response to physiological stimuli.
Transgastric endoscopic splenectomy in a porcine model appears technically feasible. Additional long-term survival experiments are planned.