Apolipoprotein E polymorphism in diabetic and non-diabetic patients: does it really contribute to atherosclerosis?
Our findings imply that apo E polymorphism is not related to the development of atherosclerosis in patients with type-2 diabetes.
β-arrestin2 regulation of CB(1)R signaling following acute and repeated THC administration was region-specific, and results suggest that multiple, overlapping mechanisms regulate CB(1)Rs. The observations that βarr2-KO mice display enhanced antinociceptive responses to acute THC and decreased tolerance to the antinociceptive effects of the drug, yet enhanced tolerance to catalepsy, suggest that development of cannabinoid drugs that minimize CB(1)R interactions with β-arrestin2 might produce improved cannabinoid analgesics with reduced motor suppression.