Do smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi?
The increased contractility of rat bronchi when exposed to DSP appears to be due to a translation mechanism.
Both primary ALT-positive and ATRX/DAXX-negative PanNETs are independently associated with aggressive clinicopathologic behavior and displayed reduced recurrence-free survival. In contrast, ALT activation and loss of ATRX/DAXX are both associated with better overall survival in patients with metastases. Therefore, these biomarkers may be used as prognostic markers depending on the context of the disease.