Is pulmonary hypertension associated with impaired exercise performance in patients with systemic sclerosis?
An exercise intolerance in patients affected by SSc is present. Impairment of exercise performance is associated with pulmonary hypertension.
These results are in agreement with those of previous ex vivo studies and indicate that exposure to heroin or, to a lesser extent, morphine, can affect morphine glucuronidation via direct non-opioid actions on the hepatocytes.