Does a basal gradient of Wnt and stem-cell number influence regional tumour distribution in human and mouse intestinal tracts?
There are variable gradients in stem-cell number, physiological Wnt activity and response to pathologically increased Wnt signalling along the crypt-villus axis and throughout the length of the intestinal tract. The authors propose that this variation influences regional mutation spectra, tumour susceptibility and lesion distribution in mice and humans.
Our results suggest that PTTG1 is a promising target for GC diagnosis and therapy.