Does irinotecan induce steroid and xenobiotic receptor ( SXR ) signaling to detoxification pathway in colon cancer cells?
Altogether, these results suggest that the SXR pathway is involved in colon cancer irinotecan resistance in colon cancer cell line via the upregulation of select detoxification genes.
We suggest that more attention should be paid to the PLR values of these patients on admission to identify individuals who may not benefit from clopidogrel during the course of ACS.