Does a Missense Genetic Variant in LRRC16A/CARMIL1 improve ARDS Survival by Attenuating Platelet Count Decline?
LRRC16A appears to mediate platelet count decline after ICU admission to affect ARDS patient prognosis.
Taken together our results demonstrate that (i) the stabilities of BRCA1/BARD1 complexes are regulated in a mutagen-specific manner, and (ii) indicate the existence of mechanisms that may be required to prevent the simultaneous recruitment of conflicting signaling pathways to sites of DNA damage.