Is local production of the alternative pathway component factor B sufficient to promote laser-induced choroidal neovascularization?
Mouse RPE cells express and secrete CFB sufficient to promote RPE damage and CNV. This further supports that local complement production may regulate disease processes; however, the reconstitution experiments suggest that additional components may be sequestered from the bloodstream. Understanding the process of ocular complement production and regulation will further our understanding of the AMD disease process and the requirements of a complement-based therapeutic.
The limitation of this systematic review includes a paucity of literature. The only positive studies were of medial branch blocks performed by the same group of authors.