Is expression of the chemokine CXCL14 in the tumour stroma an independent marker of survival in breast cancer?
The identification of prognostic significance of stromal CXCL14 in breast cancer demonstrates novel clinical relevance of a stroma-derived secreted factor and illustrates the importance of tumour compartment-specific analyses. On the basis of the prognostic signals from difficult-to-treat subgroups, CXCL14 should also be considered as a candidate drug target.
Our data suggest that beta-carotene promotes the development of PAC via increased cAMP signalling.