Does costimulatory molecule VSIG4 exclusively expressed on macrophages alleviate renal tubulointerstitial injury in VSIG4 KO mice?
The macrophage-expressed VSIG4 may act to alleviate renal tubulointerstitial injury via inhibition of T cell infiltration and secretion of inflammation related factors.
P2P-R may influence AP1 and/or JNK signaling pathways.