Is there a relationship between the presence of lung mucosa preinvasive lesions and lung cancer incidence?
The majority of smokers had mucosa lesions, but a relatively small number of them would have a cancer, and there was a poor correlation between severity of mucosalesions and incidence of cancer. Even if an evolution from preinvasive lesions to an invasive cancer is plausible and coherent with current concepts, this link does not appear strong enough to recommend the use of systematic classic endoscopy for targeting of a sub-group of higher risk smokers who would require a closer follow up.
Isoflurane concentrations between 0.6-1.2% are not associated to a dose-dependent effect on respiratory mechanics.