Does granulocyte colony-stimulating factor ameliorate coronary artery elastin breakdown in a mouse model of Kawasaki disease?
The present study indicated that the administration of G-CSF prevents elastin breakdown of the coronary arteries by enhancing the number and functions of EPCs via the NO system, and then accelerates the repair of coronary artery lesions in the KD.
There is considerable potential for decreased use of platelet transfusions with a consequent improvement in their appropriate use and cost reduction.