Does beta blockade postinjury prevent bone marrow suppression?
In an injury and shock model, administration of propranolol immediately after resuscitation significantly reduced BM suppression, and the protective effect is maintained at 7 days with daily BB. Although BB appears to improve BM function by decreasing HPC mobilization to injured tissue, there was no worsening of lung healing. Therefore, the use of propranolol after trauma and resuscitation may minimize long-term BM suppression after injury with no adverse impact on healing.
Our results suggest that, among younger adults in Australia, the association between disability and lower psychological well-being largely reflects their increased risk of exposure to adversity and reduced access to resources, rather than the presence of health conditions or impairments per se.