Do rat liver sinusoidal endothelial cells ( LSECs ) express functional low density lipoprotein receptor-related protein-1 ( LRP-1 )?
LSECs express functional LRP-1. An important implication of our findings is that LSECs contribute to the rapid removal of blood borne ligands for LRP-1 and may thus play a role in lipid homeostasis.
Taken together, we provide evidence that hypercholesterolemia can cause oxidant stress that accelerates the ageing and impairs the reconstitution capacity of HSCs.