Are polyclonal immunoglobulin E levels correlated with hemoglobin values and overall survival in patients with multiple myeloma?
Because IgE levels are dependent on Th(2) responses, these data open new perspectives in the interpretation of antitumor immune responses and pathogenesis of anemia in MM.
MMP1 expression was high in tissues and sera in patients with endometrial cancer. Lapatinib inhibited MMP1 via both HER2 and EGFR signaling pathways. Both AKT and ERK need to be inhibited for efficient MMP1 suppression by lapatinib. Activating protein-1 (AP-1) binding site of MMP1 promoter is uniquely required for MMP1 activation in endometrial cancer. Suppression of both c-fos and c-Jun bound to AP1 binding site is required for lapatinib inhibition.