Is a poor response to proton pump inhibition a contraindication for laparoscopic antireflux surgery for gastro esophageal reflux disease?
Our results do not support the assumption that a poor response to PPIs equates to a poor outcome after LARS.
These data suggest that variants at FTO influence RBL2 gene expression at large genetic distances. This observation underscores the complexity of human transcriptional regulation and highlights the utility of large human cohorts in which both genetic variation and global gene expression data are available to identify disease genes. Expedient identification of genes mediating the effects of genome-wide association study-identified loci will enable mechanism-of-action studies and accelerate understanding of human disease processes under genetic influence.