Is gln48His the prevalent myocilin mutation in primary open angle and primary congenital glaucoma phenotypes in India?
The myocilin mutation, Gln48His, represents an allelic condition involving a spectrum of glaucoma phenotypes in Indian populations, and could be a potential risk factor towards disease predisposition among patients of Indian origin. The study also highlights the role of MYOC as a candidate in different glaucoma subtypes that needs to be investigated further.
The bias is a result of both, a too coarse follow-up and an ad hoc Cox analysis in which the data sample is restricted to the observed and known event history. This is especially relevant for studies in which a considerable number of death cases are expected.