Is fluoroquinolone use associated with the change in imipenem susceptibility of Pseudomonas aeruginosa in 25 hospitals?
Single-center studies of fluoroquinolone use have reported changes in P. aeruginosa susceptibility to carbapenems. Our study finds no such association while controlling for other drug classes. As such, resistance development in individual patients versus institutions warrants further research.
Our results suggest that upregulation of the unfolded protein response at the postprandial state may represent an adaptive mechanism to counteract diet-induced stress.