Does the Wiskott-Aldrich syndrome protein permit assembly of a focused immunological synapse enabling sustained T-cell receptor signaling?
Taken together, our data show that the Wiskott-Aldrich syndrome protein is required for the assembly of focused immunological synapse structures allowing optimal signal integration and sustained calcium signaling.
These results show that transmural pressure increases nNOS expression and NO release in rat smooth muscle cells by a mechanism involving the mitogen-activated protein kinase pathway, but independent from the local formation of angiotensin II.