Does oral administration of fomepizole produce similar blood levels as identical intravenous dose?
This is the first study that effectively determines a human Vmax and Km for p.o. and i.v. fomepizole. p.o. and i.v. administration of fomepizole result in similar pharmacokinetic parameters.
The high rate of health seeking in public health facilities seems unusual in the African context, which bodes well for high coverage with artemisinin-based combinations, even if only deployed within the public sector. However, despite no or modest charges for public sector primary healthcare, households frequently incur catastrophic expenditure on a single malaria episode.