Does increasing histone acetylation in the hippocampus-infralimbic network enhance fear extinction?
These studies show that the memory modulating ability of drugs that enhance acetylation is sensitive to a variety of behavioral and molecular conditions. We further identify transcriptional changes in the hippocampal-infralimbic circuit associated with extinction enhancements induced by the histone deacetylase inhibitor NaB.
These results suggest that STN may be a useful marker associated with the prognosis of patients with advanced gastric cancer.