Does apolipoprotein E genotype influence presence and severity of delusions and aggressive behavior in Alzheimer disease?
The present study showed that the APOE epsilon4 genotype modifies neuropsychiatric and behavioral phenotype in AD. In particular, it was shown that delusions and agitation/aggression were more common and severer among homozygous APOE epsilon4 carriers than among heterozygous or APOE-epsilon4-negative patients.
These results are consistent with a potential pro-atherogenic role for extracellular histones, which should be investigated further.