Are high-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α pathway?
Our results demonstrated that PPARα agonists or antioxidants are associated with improvement of the circulating FFA and TGs levels and this prevents HFD-induced renal lipotoxicity and hypertension by the activation of PPARα and its downstream signals of both FoxO3a and PGC-1α.
Intact genetic material was present in all 4 commercially processed human allografts. Tissue processing did not completely eliminate intact DNA segments. The size of the intact DNA and the concentration of DNA varied widely based on tissue processing methods.