Does gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induce resistance to CCR5-using HIV-1?
ZFNCCR5Δ32 is a specific and efficient tool for the generation of CCR5 knockouts. Its ability to mimic the natural CCR5Δ32 phenotype in the absence of relevant off-site cutting events suggests that ZFNCCR5Δ32 might be safe in clinical research.
With our pilot project we were able to show that such a programme is feasible, can be well integrated into clinical routine and is successful.