Is l-arginine catabolism driven mainly towards nitric oxide synthesis in the erythrocytes of patients with type 2 diabetes at first clinical onset?
l-Arg catabolism is driven mainly towards NO synthesis in RBCs of patients with type 2 diabetes at first clinical onset. The decreased RBC arginase activity could be considered a potential mechanism of increased RBC NO production in early diabetes. Therefore, the RBC pool would represent a potentially compensatory intravascular compartment for endothelial dysfunction in diabetes.
These findings demonstrate that I/R results in augmented endothelial Ca2+ responses that appear to be downstream of the receptor level. Moreover, these data suggest that this augmented Ca2+ response contributes to the potentiated EDHF-mediated dilations after I/R.