Does selective homocysteine-lowering gene transfer attenuate pressure overload-induced cardiomyopathy via reduced oxidative stress?
Plasma homocysteine levels predict heart failure incidence in epidemiological studies. Transverse aortic constriction (TAC) induces pressure overload. Selective homocysteine-lowering gene therapy reduces mortality after TAC. Selective homocysteine lowering attenuates cardiac hypertrophy and fibrosis after TAC. Decreased homocysteine levels enhance diastolic function and lower oxidative stress.
Local richness of ants in the FB and SKB is not exceptional by global standards. Initial analyses suggest that regional diversity is also not exceptional for the group. It seems unlikely that the mechanisms which have contributed to the development of extraordinarily high regional plant diversity in these biomes have had a strong influence on the ants.