Does insulin stimulation regulate AS160 and TBC1D1 phosphorylation sites in human skeletal muscle?
These data show that insulin differentially regulates AS160 and TBC1D1 phosphorylation in human skeletal muscle. Impaired insulin-stimulated glucose uptake in T2D subjects is accompanied by dysregulation of AS160 and TBC1D1 phosphorylation in skeletal muscle, suggesting that these proteins may regulate glucose uptake in humans.
The administration of epinephrine alone may increase early resuscitation rate in a cardiac arrest model compared with placebo group. Moreover, the combination of naloxone and epinephrine may significantly increase resuscitation rate. The duration of ROSC in combination group is much shorter than that in the other 2 groups.