Is off-label use a risk factor for adverse drug reactions in pediatric patients?
Use of off-label medicines were more likely to be implicated in an ADR than labeled medicines. This off-label use would be acceptable if evidence of potential benefits outweighs ADRs risk.
TM application did not reduce MSBS for CSE but significantly reduced MSBS for GB when the smear layer was removed before paste treatment. Preconditioning did not improve or worsen dentine MSBS for CSE or GB with/without TM, except when CC was used with GB.