Does early-diastolic left ventricular lengthening imply pulmonary hypertension-induced right ventricular decompensation?
Early-diastolic LV lengthening reflects inadequate structural adaptation of the RVFW to increased myofibre load and is therefore a useful, non-invasive, and easily obtainable predictor of PH-induced RV dysfunction.
These findings indicate that targeting the renin-angiotensin system, by stimulation of AT2Rs with C21, improves neurological function in aged rats with stroke over a sustained period of 21 days. These findings encourage further research into AT2R agonists and stroke, and offer hope for effective therapeutics for treating stroke.