Does oral administration of doxycycline reduce collagenase and gelatinase activities in extracts of human osteoarthritic cartilage?
Oral administration of doxycycline significantly inhibited collagenase and gelatinase activity in human OA cartilage. The effective dose is likely to be well tolerated during chronic administration, e.g., in a clinical trial to assess the potential of the drug to modify cartilage breakdown in OA.
Screening for prostate cancer remains controversial. We found a low rate of DRE among veterans in whom prostate cancer screening was entertained. Although the provider gender does not seem to influence DRE, resident physicians were less likely to perform DRE than other providers. Our finding that BMI>40 kg/m 2 is associated with a lower rate of DRE than those with BMI<30 kg/m 2 is consistent with screening for other cancers and should be explored further.