Potentially inappropriate prescribing in elderly veterans: are we using the wrong drug, wrong dose, or wrong duration?
For the most part, the Zhan criteria did not explain inappropriate prescribing, which includes problems related to dose and duration of prescriptions. Interventions targeted at prescriptions for pain relievers, benzodiazepines, antidepressants, and musculoskeletal agents may dramatically decrease inappropriate prescribing and improve patient outcomes.
A distributed network of mostly left-hemisphere structures, which are putative P600 generators, appears important for successful verbal encoding (with New>Old responses to congruous words in normal elderly). This network appears dysfunctional in mild AD patients, as reflected in decreased word repetition effects particularly in left association cortex, paralimbic and MTL structures.