Is organ damage in zymosan-induced multiple organ dysfunction syndrome in mice mediated by inducible nitric oxide synthase?
The current results strongly argue against an essential and causative role of iNOS in the development of organ damage in our murine model of MODS.
The order of potency of the agonists, and the effects of the antagonists, both indicate that the effect of substance P on paired pulse depression is mediated by neurokinin-1 receptors.