Does intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induce catalepsy in mice?
This study showed that pharmacological disruption of the endogenous NO-sGC signaling in the central nervous system induces long-lasting catalepsy in mice. Moreover, the cataleptic effect of NOS inhibition correlates with the decrease in NO( x ) products formation in the striatum. The results give further support to the hypothesis that NO plays a role in motor behavior control mediated, at least in part, by cyclic guanosine monophosphate production in the striatum.
Women were deemed to have sufficient relevant knowledge of the benefits and harms if they answered at least half of the items correctly.