Do th17 cytokines interleukin ( IL ) -17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways?
Our results suggest that the Th17 cytokines IL-17 and IL-22 mediate distinct downstream pathways that contribute to the psoriatic phenotype: IL-17 is more proinflammatory, while IL-22 retards keratinocyte differentiation.
Confidence ratings and visual search of the expert radiologists appear to be affected by changing prevalence expectations. The impact of prevalence expectation appears to be more apparent for normal images.