Does the new malononitrilamide immunosuppressant FK778 prolong corneal allograft survival in the rat keratoplasty model?
Systemic immunosuppression with FK778 prolongs graft survival in the rat keratoplasty model. FK778's efficacy is comparable with that of MMF in preventing immunologic graft rejection.
Fluconazole led to significant increases in nevirapine exposure, but was not associated with evidence of increased hepatotoxicity.