Is dNAH5 associated with total lung capacity in chronic obstructive pulmonary disease?
In COPD, TLCCT was associated with a SNP in dynein, axonemal, heavy chain 5 (DNAH5), a gene in which genetic variants can cause primary ciliary dyskinesia. DNAH5 could have an effect on hyperinflation in COPD.
We have developed a noninvasive method to measure skin PpIX in patients with EPP. Skin PpIX is dependent on erythrocyte PpIX and exposure of the skin to light. This method can be used for objective monitoring of treatment effect.