Does hepatitis C virus inhibit interferon signaling through up-regulation of protein phosphatase 2A?
We conclude that HCV interferes with interferon-alpha signaling via up-regulation of PP2Ac, hypomethylation of STAT1, and increased STAT1-PIAS1 association, resulting in reduced transcriptional activation of interferon-alpha-stimulated genes.
Women who have intercourse around ovulation should ideally be offered a copper intrauterine device. Women with body mass index>25 kg/m(2) should be offered an intrauterine device or UPA. All women should be advised to start effective contraception immediately after EC.