Does hyperbaric hyperoxia alter innate immune functional properties during NASA Extreme Environment Mission Operation ( NEEMO )?
Living in the NEEMO habitat for 14 days induced significant immune alterations as seen by an activation of adhesion molecules and vice versa higher sensitivity towards inhibition. This investigation under hyperbaric hyperoxia is important especially for Astronauts' immune competence during extravehicular activities when exposed to similar conditions.
Our results indicate that elevated IL-27 strongly correlates with EOS and may provide additional diagnostic value along with PCT.