Does chronic blockade of cannabinoid CB2 receptors induce anxiolytic-like actions associated with alterations in GABA ( A ) receptors?
The opposing behavioural and molecular changes observed after chronic treatment with AM630 or JWH133 support the key role of CB(2) receptors in the regulation of anxiety. Indeed, the efficacy of AM630 in reducing the anxiety of the spontaneously anxious DBA/2 strain of mice strengthens the potential of the CB(2) receptor as a new target in the treatment of anxiety-related disorders.
This study provides preliminary evidence that VEGF polymorphisms are associated with a differential presentation of diabetic vascular complications.