Is phospholipid Scramblase 1 , an interferon-regulated gene located at 3q23 , regulated by SnoN/SkiL in ovarian cancer cells?
Our findings warrant further investigation into the role of PLSCR1 in ovarian cancer development and chemoresistance.
Our study suggests that ZNF703 expression levels may predict tamoxifen sensitivity. Tamoxifen should be administered with caution to those patients bearing tumors with ZNF703 overexpression. However, large clinical trials and prospective clinical studies are needed to verify these results.