Does incorporating initial treatments improve performance of a mortality prediction model for patients with sepsis?
A sepsis disease risk score that incorporates information about the use of mechanical ventilation and vasopressors is superior to models that rely only on demographic information and comorbidities. Until administrative datasets include clinical information (such as vital signs and laboratory results), models such as this one could allow researchers to conduct observational studies of treatment effectiveness in sepsis patients.
Immobilization stress induces bladder mast cell activation and the secretion of proinflammatory mediators, which are inhibited by sodium hyaluronate. Intravesical sodium hyaluronate may be a useful therapeutic option for interstitial cystitis, especially in patients with bladder mastocytosis who have symptom exacerbation with stress.