Does experimental TLR4 inhibition improve intestinal microcirculation in endotoxemic rats?
The TLR4 pathway may be a target in clinical Gram-negative sepsis since administration of the TLR4 antagonist CRX-526 improved intestinal microcirculation parameters in experimental endotoxemia.
Our study shows that environmental temperature during the larval stages as well as during the adult stages affects Anopheles life-history parameters. Data on how temperature and other climatic factors affect vector life-history parameters are necessary to parameterise more reliably models predicting how global warming may influence malaria transmission.