Does long-term treatment with ivabradine in post-myocardial infarcted rats counteract f-channel overexpression?
The beneficial effects of ivabradine may be due to the reversal of electrophysiological cardiac remodelling in post-MI rats by reduction of functional overexpression of HCN channels. This is attributable to transcriptional and post-transcriptional mechanisms.
In summary, L233 is a promising anticancer drug for the development of novel chemotherapies in the future.