Is continuous mixed venous oxygen saturation , not mean blood pressure , associated with early bupivacaine cardiotoxicity in dogs?
cSvO(2), but not MBP, is associated with CO changes in bupivacaine-induced cardiac depression during the early period of bupivacaine intoxication. Decrease of MBP with low cSvO(2) observed during the late period might imply severe cardiac depression induced by bupivacaine infusion.
Our study did not confirm that inflammatory COPD may be a CHD risk equivalent. However, due to the small size of the "inflammatory" COPD group, further prospective replication and validation is needed. Moreover, given that COPD results from inflammation, the systemic inflammation associated with COPD may have worsened comorbid conditions and may have lead to the increased total mortality found in the COPD with inflammation and COPD + CHD groups which requires further investigation.