Does estetrol bind sex hormone binding globulin or increase its production by human HepG2 cells?
These data indicate that SHBG has no influence on the plasma distribution of E4 or its availability to target tissues. In addition, it is shown that E4 has no effect on SHBG production by human hepatocytes.
Two ARE motifs were identified to be responsible for androgen-induced MMP-2 expression in prostate cancer cells.