Is the myotonic dystrophy type 2 ( DM2 ) gene product zinc finger protein 9 ( ZNF9 ) associated with sarcomeres and normally localized in DM2 patients ' muscles?
ZNF9 is abundantly expressed in human myofibres, where it is located in the sarcomeric I bands, and no modification of this pattern is observed in DM2 muscles.
This pathway by GMDS mutation could be a novel type of cancer progression through cellular fucosylation and NK cell-mediated tumor surveillance.