Does the RL-ET-14 cell line mediate expression of glutamine synthetase through the upstream enhancer/promoter region?
The 'RL-ET-14' factor specifically induces GS expression, working via its upstream enhancer in a beta-catenin-dependent fashion.
These data establish the role of SIN3 isoforms in regulating distinct biological processes. This study substantially contributes to our understanding of the complexity of gene regulation by SIN3.