Does inhibition of Interleukin-10 Signaling induce Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice?
Our study highlights a novel interplay between ApoE and IL-10 in maintaining gut homeostasis and that such crosstalk may play a critical role in the pathogenesis of inflammatory bowel disease. Gut sterilization and the cohousing experiment suggest that microbiota play a pivotal role in the development of inflammatory bowel disease in mice lacking ApoE.
The websites were in partial agreement with the French recommendations. To date, the pediatrician remains the main actor in guiding parents on food diversification.