Is excessive fat accumulation associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men?
The AA-variant at position -308 in the promoter region of the TNF alpha gene could be an important genetic factor behind excessive fat accumulation in women.
Basal release of NO does not appear to be impaired in SHR, but represents a major counter-regulatory mechanism in this genetic model of arterial hypertension.