Does amitriptyline reduce rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome?
The tricyclic antidepressant amitriptyline reduces brain activation during pain in the perigenual (limbic) anterior cingulated cortex and parietal association cortex. These reductions are only seen during stress. Amitriptyline is likely to work in the central nervous system rather than peripherally to blunt pain and other symptoms exacerbated by stress in IBS.
Earlier closure of gastroschisis after silo placement was associated with earlier feed initiation and shorter time to full feeds.