Does uterine epithelial cell regulation of DC-SIGN expression inhibit transmitted/founder HIV-1 trans infection by immature dendritic cells?
Our results provide the first direct evidence for uterine epithelial cell regulation of dendritic cell transmission of infection with reference and transmitted/founder HIV-1 variants. These findings have immediate implications for designing strategies to prevent sexual transmission of HIV-1.
This study identifies new genes and variants that may increase an individual's vulnerability to develop heroin addiction.