Is corticosteroid insensitivity reversed by formoterol via phosphoinositide-3-kinase inhibition?
FM reversed oxidative stress-induced corticosteroid insensitivity and decreased β(2) adrenoceptor-dependent cAMP production via inhibition of PI3Kδ signalling. FM will be more effective than SM, when combined with corticosteroids, for the treatment of respiratory diseases under conditions of high oxidative stress, such as in COPD.
A diagnosis of major depression in older medical inpatients is independently associated with poor mental health in their informal caregivers 6 months later.