Does endothelin-1 signalling control early embryonic heart rate in vitro and in vivo?
Endothelin-1 is required to maintain a sufficient heart rate, as well as to prevent arrhythmia during early development of the mouse heart. This is achieved through ETb receptor, which stimulates Ca(2+) leak through IP3 receptors.
Our results suggest that mild-intensity exercise could prevent prefrontal volume reduction due to aging and impede cognitive decline.