Does an HIV-1 capsid binding protein TRIM11 accelerate viral uncoating?
We identify TRIM11 as a new HIV-1 capsid binding protein. Our data also reveal that TRIM11 restricts HIV-1 reverse transcription by accelerating viral uncoating, and microtubule dynamics is implicated in TRIM11-imposed block to early events of HIV-1 replication.
Ibutilide is an effective and well tolerated drug for the rapid termination of Afb or Afl of recent onset associated with symptomatic and/or hemodynamically unstable disorders, and it is most efficacious (>or = 90%) when the atrial arrhythmia is<or = 1 week in duration. Proarrhythmic events are readily manageable in a monitored unit with access to appropriate treatment.