Are protective CD8 memory T cell responses to mouse melanoma generated in the absence of CD4 T cell help?
This work establishes that CD4 T cell help is dispensable for the generation of protective memory T cell responses to melanoma. Our findings support further use of CD4 T cell depletion therapy for inducing long-lived immunity to cancer.
The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.