Does ago2 immunoprecipitation identify predicted microRNAs in human embryonic stem cells and neural precursors?
Extending the classic definition of microRNAs, this large number of new microRNA genes, the majority of which are less conserved than their canonical counterparts, likely represent evolutionarily recent regulators of early differentiation. The enrichment in Ago2 containing complexes, the presence of chromatin marks indicative of regulated gene expression, and differential expression over development all support the identification of 146 new microRNAs active during early hESC differentiation.
Data of the study suggest that the oral administration of the aqueous extract of O. gratissimum may impair naturally generated oxidant/toxicant activity and thereby enhance specific activities of hepatic antioxidant enzymes in rats.