Is in vitro differentiation of mouse brown preadipocytes enhanced by IGFBP-3 expression and reduced by IGFBP-3 silencing?
Brown adipocyte growth and differentiation in vitro were affected by the manipulation of IGFBP-3 expression, suggesting that IGFBP-3 is a factor regulating brown adipocyte fate.
Chronic hypoxaemia was associated with lower quadriceps endurance time and worsened muscle oxidative stress at rest and after exercise. Increased muscle neutrophil levels could be a source of the increased baseline oxidative damage. The involvement of a muscle inflammatory process in the exercise induced oxidative stress of patients with COPD remains to be shown.