Is sLC5A8 gene , a transporter of butyrate : a gut flora metabolite , frequently methylated in African American colon adenomas?
SLC5A8 is highly methylated in AA colon adenomas which points to its potential use as a marker for early detection. The MSI rate is similar to that found in colon cancer tumors in AAs. These findings suggest that both processes stem from the same epigenetic and genetic events occurring at an early stage in colon carcinogenesis in AAs.
This study is the first to demonstrate the feasibility of altering the coloration of flaps and grafts applied from remote body sites to the face using epidermal overgrafting from the scalp in Caucasian patients. Significant improvement in coloration in the treated areas compared with the adjacent facial skin has been demonstrated by this technique. The authors believe that epidermal overgrafting is a useful adjunct for enhancing color aesthetics in facial reconstruction and may well lower the threshold for use of remote flaps and grafts previously ignored because of poor color match.