Does intraocular hemorrhage cause retinal vascular dysfunction via plasma kallikrein?
Intraocular hemorrhage increases retinal vascular permeability and leukostasis, and these responses are mediated, in part, via PK. Intravitreal injections of either PK or collagenase, but not bradykinin, induce retinal hemorrhage in rats. PK exerts collagenase-like activity that may contribute to blood-retinal barrier dysfunction.
Our results show that the integrity of the endosomal system is required for lysosome biogenesis and productive autophagy in vivo.