Is there a difference in outcome after radical prostatectomy between patients with biopsy Gleason sums 4, 5, and 6?
Despite weak correlation between biopsy and pathologic Gleason sum among men with biopsy Gleason sum 4-6 tumors, grade was a significant independent predictor of PSA failure following RP. In the range of 4-6, biopsy Gleason sum acted as a continuous variable for predicting PSA failure. The routine use of Gleason sums 4 and 5 to grade prostate needle biopsy specimens should not be abandoned.
Together these results argue that some sharp vision is fundamental to compensation to impose myopia. The significance of this new finding in relation to the processes underlying active emmetropization is discussed.