Are small macrophages present in early childhood respiratory disease?
In paediatric patients small macrophages are not unique to CF, but their establishment as the dominant phenotype in adults may be due to chronicity of inflammation and infection.
In our study, we detect the expression and function of Smad4 by suppressing p53 expression in MCF7, trying to figure out the relationship and signaling pathway between them. In this study, we try to found the affection of p53 on Smad4, so as to induce apoptosis in tumor cell, achieving the goal of targeted cancer prevention and treatment.