Is alefacept treatment in psoriatic arthritis : reduction of the effector T cell population in peripheral blood and synovial tissue associated with improvement of clinical signs of arthritis?
The changes in ST, together with the improvement in clinical joint scores, after treatment with alefacept support the hypothesis that T cell activation plays an important role in this chronic inflammatory disease. Furthermore, since alefacept, a T cell-specific agent, led to decreased macrophage infiltration, the data indicate that T cells are highly involved in synovial inflammation in PsA.
VO(2max) can be accurately predicted from PPO when using a continuous ramp protocol, possibly even more accurately than when using a stepwise testing protocol. 40-km TT performance (s) in trained cyclists can be predicted most accurately by PPO adjusted for body mass (W/kg(0.32)). As both VO(2max) and 40-km TT performance can be accurately predicted from a PPO test, this suggests that (well)-trained cyclists can possibly be monitored more frequently and with fewer tests.