Does indocyanine green R15 ratio depend directly on liver perfusion flow rate?
ICG R15 is reliable within one group at defined perfusion rates. Doubled perfusion rates contribute to higher ICG clearance. For clinical application we would like to suggest considering cardiac output of the patient for interpretation of ICG ratios.
These data indicate that increased activity of NF-κB very early in life, presumably in conjunction with oxidative stress, can lead to the development of hypertension. Perinatal inhibition of NF-κB has persistent antihypertensive effects. This could be related to a short phase of enhanced sodium excretion at an early age, and persistent changes of intrarenal vasoreactivity to ROS.