Does [ Vasoactive intestinal peptide attenuate apoptosis and iNOS protein expression induced by cerebral ischemia in the rat ]?
VIP has a neuroprotective effect on cerebral ischemia and reperfusion. The mechanism seems to involve decreasing the apoptosis and down-regulating the iNOS expression.
Our data suggest that spinal 5-HT3 receptors are likely to play a role in alpha-2-delta-1-mediated behavioural hypersensitivities through a descending serotonergic facilitation.