Is a polymorphism of MS4A2 ( - 109T > C ) encoding the beta-chain of the high-affinity immunoglobulin E receptor ( FcepsilonR1beta ) associated with a susceptibility to aspirin-intolerant asthma?
FcepsilonR1beta-109T > C polymorphism may increase expression of MS4A2 by mast cells, leading to enhanced release of proinflammatory mediators in the asthmatic airway, contributing to increased susceptibility to AIA.
We conclude that IL-4 is specific marker for the diagnosis of β-lactam-induced hypersensitivity. Moreover, IL-4 in combination with INF-γ is more sensitive for the diagnosis of these reactions. This study also concludes that both IL-4 and INF-γ may play an active role in the onset of allergic reactions against β-lactam antibiotics.