Does vesicle targeting to the apical domain regulate bile excretory function in isolated rat hepatocyte couplets?
The findings support the view that apical membrane transport activity in the rat hepatocyte is highly regulated by the insertion of vesicles into this domain and that this process involves both microtubule-dependent and -independent mechanisms.
Urology in Canada is becoming less competitive. Residency positions have doubled since 2002 whereas the number of applicants remains static. This trend was not reflected in other surgical specialities. Factors accounting for this may include poor undergraduate exposure, demand for specialties with controllable lifestyles, gender shifts in undergraduate medicine, and lack of role models. The need for undergraduate exposure to urology and vetting numbers of residency positions remains a matter of paramount importance.