Is protease-activated receptor ( PAR ) 2 , but not PAR1 , involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model?
PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD) patients.
The method combined differentiation induction effect of HDAC inhibitors and selective culture system to derive neural cells from ES cells, and implied the involvement of epigenetic regulation in neural differentiation.