Does early withdrawal of cyclosporine A improve 1-year kidney graft structure and function in sirolimus-treated patients?
These results suggest that early withdrawal of CsA is a safe option, which allows a significant reduction of chronic histologic damage, particularly vascular injury, of cadaveric kidney allografts.
It is unlikely that the lack of change in the excitability indices reflects a balance between the effects of bradykinesia ("underactivity") and the effects of rigidity and tremor ("overactivity") on the motoneuron and its axon. It is more likely that plastic changes in motoneuron properties do not occur symmetrically with decreases and increases in activity, being more profound when activity levels are interrupted and less obvious when they are enhanced.