Does deglycosylation influence the oxidation activity and antigenicity of myeloperoxidase?
Deglycosylation decreased oxidation activity of MPO and its binding with ceruloplasmin. Deglycosylation could also decrease the microbicidal effect of MPO, which might contribute to severer infections and inflammation. Deglycosylated MPO presented less antigenicity to MPO-ANCA, which indicated the contribution of glycans to MPO epitopes.
We have confirmed that SGA is an accurate predictor of mortality in PD patients, and its predictive value is independent of the hydration status. Predictive power of SGA was not affected when LTI and FTI were included in multivariate analysis. Patients with low LTI were different from patients with low SGA (associated with high FTI). Sensitivity and specificity of Body Composition Monitor to diagnose patients with low SGA readings were poor (area under the curve for receiver operator characteristics analysis 0.66). The phenomenon of reverse epidemiology (high FTI predicting a survival advantage) was found in our PD cohort.