Does gestational ethanol exposure disrupt the expression of FGF8 and Sonic hedgehog during limb patterning?
We propose a model where ethanol disrupts the AER/ZPA positive feedback loop to induce postaxial malformations. Preaxial malformations seen at higher ethanol dosage suggest FGF8 as a critical target of ethanol in producing limb defects.
We propose that Foxl1 is a bona fide marker of the facultative progenitor cell in the mouse liver.