Are direct effects of recombinant human endostatin on tumor cell IL-8 production associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic cancer?
rhES downregulated IL-8 levels and induced endothelial cell apoptosis in the more aggressive cell line in a xenograft model of pancreatic cancer. Nonetheless, these effects were not sufficient to produce significant inhibition of tumor growth.
The use of statins was not protective against the recurrence of adenomatous polyps.