Does ambient Fine Particulate Matter suppress In Vivo Proliferation of Bone Marrow Stem Cells through Reactive Oxygen Species Formation?
PM exposure significantly decreased the population of BMSCs due to diminished proliferation via ROS-mediated mechanism (could be partially via inhibition of Akt signaling).
Our findings, together with the prior biological evidence, suggest the SOX6 gene's importance in co-regulation of obesity and osteoporosis.