Does [ Sphingosine kinase regulate hepatocyte growth factor-induced migration of endothelial cells ]?
These findings show that SPK activation plays important roles in the regulation of HGF-induced migration of endothelial cells.
We have derived a robust gene expression landscape of breast cancer that reflects known subtypes as well as heterogeneity within these subtypes. By applying the modules to TP53-mutated samples we shed light on the biological consequences of non-functional p53 in otherwise low-proliferating luminal breast cancer. Furthermore, as in the case of the stroma module, we show that the biological and clinical interpretation of a set of co-regulated genes is subtype-dependent.