Does pCBP1/HNRNP E1 protect Chromosomal Integrity by Translational Regulation of CDC27?
The RNA-binding protein HNRNP E1 mediates translational regulation of the cell-cycle regulator CDC27 and that dysregulation of CDC27 leads to aneuploidy. In addition, high CDC27 expression in breast cancer patient tumor specimens significantly predicts disease recurrence, suggesting a novel role for CDC27 as a predictor of relapse. Mol Cancer Res; 14(7); 634-46. ©2016 AACR.
These findings add to the evidence base that childhood disadvantage is associated with adult smoking behaviours and highlights the importance of the early childhood social environment for the development of these.