Does positive allosteric modulation of the adenosine A2a receptor attenuate inflammation?
AEA061 increases affinity and Bmax of A2aR to adenosine, thereby increasing adenosine potency and efficacy, which translates to enhanced A2aR responsiveness. Since the A2aR negatively regulates inflammation, PAMs of the receptor offer a novel means of modulating inflammatory processes.
The findings are compatible with the hypothesis that there is an association between endogenously synthesized MUFAs and cancer death.