Are genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers?
Three SNPs in CACNA1D or CACNA1C are genetic polymorphisms conferring sensitivity to the antihypertensive effects of L-type dCCBs in patients with hypertension. The BP reduction by L-type dCCBs might be predicted by evaluating these polymorphisms.
RNAi targeting the promoter of HPV16 E6/E7 acts effectively in vitro and in vivo, especially through intratumoral delivery, and may be a candidate therapeutic strategy for cervical cancer.