Do senescent Carcinoma-associated Fibroblasts Upregulate IL8 to Enhance Pro-metastatic Phenotypes?
Findings show that senescent cancer associated fibroblasts secret excess interleukin 8 to promote pancreatic cancer invasion and metastasis; thus, senescent CAFs represent a phenotypic subtype, challenging conventional assumptions that CAFs are a homogeneous population.
These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.