Does the HOXB13 G84E Mutation be Associated with an Increased Risk for Prostate Cancer and Other Malignancies?
Our study confirms the association between the HOXB13 G84E variant and prostate cancer and suggests a novel association between G84E and leukemia and a suggestive association with bladder cancer. Future investigation is warranted to confirm these associations in order to improve our understanding of the role of germline HOXB13 mutations in human cancer.
The development of atherosclerosis in patients with Type III HLP is modulated by variation in the APOA5 gene.