Does schistosoma japonicum HSP60-derived peptide SJMHE1 suppress delayed-type hypersensitivity in a murine model?
Our study proves that the parasite-driven peptide suppresses DTH in mice, which may confer a new option for inflammation treatment.
In this work, we identified surrogate markers (VDV genes) for in vivo VEGF signaling in tumors and showed clinical data supporting a correlation between pretreatment VEGF bioactivity and the subsequent efficacy of anti-VEGF therapy. We propose that VDV genes are candidate biomarkers with the potential to aid the selection of novel indications as well as patients likely to respond to anti-VEGF therapy. The data presented here define a diagnostic biomarker hypothesis based on translational research that warrants further evaluation in additional retrospective and prospective trials.