Does joint instability lead to long-term alterations to knee synovium and osteoarthritis in a rabbit model?
BTX-A induced joint instability in a muscle weakness model uniquely leads to alterations in gene expression and histological changes in the synovial membranes and cartilage in otherwise intact knee joints. These results lead to the conclusion that joint instability may promote an inflammatory intraarticular milieu, thereby contributing to the development of OA.
Measurements of serum CysC concentrations lead to underestimation of renal dysfunction in pediatric patients with CKD.