Does factor XIII A-Subunit V34L Variant affect Thrombus Cross-Linking in a Murine Model of Thrombosis?
Mutations in the activation peptide of full-length recombinant FXIII regulate activation rates by thrombin, and V34L influences in vivo thrombus formation by increased cross-linking of the clot.
SB225002 inhibits angiogenic activity of IL-8 by blocking its binding with CXCR2 in the early stage of CNV, which may provide a potential new therapeutic strategy for CNV.