Does adult bone marrow stromal cell-based tissue-engineered aggrecan exhibit ultrastructure and nanomechanical properties superior to native cartilage?
The higher proportion of full-length monomers, longer GAG chains and greater stiffness of the BMSC-aggrecan makes it biomechanically superior to adult cartilage-aggrecan. Aggrecan stiffness was not solely dependent on fixed charge density, but also on GAG molecular ultrastructure. These results support the use of adult BMSCs for cell-based cartilage repair.
Either PD develops selectively in the enterically α-Syn-positive population subset or PD induces this expression. Absence of increased α-Syn expression in AD points to differences in pathogenesis.