Is polymorphonuclear leukocyte rigidity defective in patients with chronic renal failure?
The results indicate that PMN rigidity is defective in end-stage chronic CRF patients and is further increased 60 min after initiation of HD, regardless of the nature of the HD membrane used. PMN activation, increased TNF-alpha and IL-1beta levels, or a direct PMN impairment may cause the observed cell rigidity.
Oxidative stress was principally involved in the pathogenesis of chronic pancreatitis with fibrosis.