Do excitation patterns of simultaneous and sequential dual-electrode stimulation in cochlear implant recipients?
Peripheral neural activation patterns suggest a similar spread of excitation for SI dual-electrode stimulation and the intermediate PE. The spread of excitation associated with sequential dual-electrode stimulation is generally different from the intermediate PE, and it varies depending on the order of the sequential pulses.
Sunitinib increases neuronal survival and this neurotrophic effect is mediated by NF-κB. Also, the inflammatory proteins COX2 and NOS2 are upregulated by sunitinib in an NF-κB-dependent manner. These data are in agreement with a growing literature suggesting beneficial effects for inflammatory mediators such as NF-κB, COX2 and NOS2 in neurons. Further work is needed to fully explore the effects of sunitinib in the brain and its possible use as a treatment for glioblastoma. Finally, sunitinib may be useful for the treatment of a range of central nervous system diseases where neuronal injury is prominent.