Is emergency Department Utilization in Children < 36 Months an Independent Risk Factor for Maltreatment?
In efforts to identify children at risk for maltreatment, objective assessments such as PED utilization are potential markers to utilize to aid in recognition. Unfortunately, there are many risk factors for increased PED utilization that act as confounders for this marker. Future work is necessary to identify children at risk for maltreatment in the ED.
Overexpression of p14ARF is limited to a fraction of the p16INK4A-expressing cells and therefore it is likely that p14ARF- and p16INK4A expression are not induced by the same mechanisms. Before expression of p14ARF can be linked to invasion or invasive phenotype, larger series of (micro-) invasive squamous lesions need to be studied.