Is the majority of nitric oxide synthase in pig heart vascular and not neural?
(1) the majority of NOS activity in the pig heart is in vascular endothelium, consistent with the concept of nitric oxide as a regulator of coronary blood flow; less is present in the endocardium; (2) paucity of nerves with NOS activity probably indicates that this particular type of NANC neural tissue does not affect coronary blood flow directly; and (3) although muscle fibres have no discernible NOS activity, the rich vascular supply in close proximity may subserve some myocardial function of nitric oxide.
This study demonstrated that intramural delivery of advanced c-myc neutrally charged antisense morpholino compound completely inhibits c-myc expression and dramatically reduces neointimal formation in a dose dependent fashion in a porcine coronary stent restenosis model, while allowing for complete vascular healing.