Is the efficiency of male fertility restoration dependent on the recovery kinetics of spermatogonial stem cells after cytotoxic treatment with busulfan in mice?
The loss and restoration of fertility after busulfan treatment are direct consequences of SSC loss and expansion. Our data suggest that there is a threshold in SSC numbers that allows for male fertility restoration and that the testicular somatic environment responds rapidly and temporarily to the loss of spermatogonia, including SSCs, by altering GDNF mRNA levels. This study provides fundamental information to clinically apply SSCs for male fertility restoration in the future.
We conclude that there is no need to delay CABG for the patients who are smokers.