Does ginkgolide B inhibit platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets?
Ginkgolide B potently inhibited the expression of PF4 and CD40L in thrombin-activated platelets. Ginkgolide B partially decreased ATP release and Ca(2+) efflux. The mechanism might be associated with the inhibition of Syk and p38 MAPK phosphorylation. These results demonstrated that ginkgolide B might be a promising drug on inhibiting platelet function and reducing inflammation in atherosclerosis.
Our results indicate that treatment of HP infection by eradication regimen (triple therapy only) is not enough to prevent recurrence of ulcer in the Jordanian population. Thus, we recommend maintenance acid suppression following standard H. pylori eradication regimen to maintain remission.