Does network-based bioinformatics analysis of spatio-temporal RNA-Seq data reveal transcriptional programs underpinning normal and aberrant retinal development?
Thus, our approach was predictive of a phenotype before it presented histologically. Our strategy can be extended to investigating the development and/or disease progression of other tissue types.
These results suggest that increased expression of DLX2 may correlate with the advanced stage of gastric adenocarcinoma, and it may contribute to tumor development.