Does microRNA1 modulate oxLDL-induced hyperlipidemia by down-regulating MLCK and ERK/p38 MAPK pathway?
Taken together, this study demonstrated that the effect of miR1 on hyperlipidemia is mediated through down-regulation of MLCK and the ERK/p38 MAPK pathway.
The present study provides the first evidence that cardiomyocytes are a prominent source of OP in vivo and suggests that induction of OP expression is strongly associated with ventricular hypertrophy.