Does acetylation of PGK1 promote liver cancer cell proliferation and tumorigenesis?
These findings demonstrate a novel regulation of PGK1 as well as its important role in liver cancer progression. (Hepatology 2016).
In patients treated by permanent prostate brachytherapy, hormonal manipulation improved the biochemical outcome for those at high-risk and those with an initial PSA of>or= 10 ng/mL, but not for those with intermediate-risk features. The use of hormonal therapy for>4 months conferred no additional biochemical advantage over short-course regimens. Because the follow-up in hormone-naïve patients was longer than that for those receiving hormonal manipulation, additional follow-up will be mandatory to confirm the durability of these findings.