Does hormone replacement therapy lead to increased plasma levels of platelet derived microparticles in postmenopausal women?
Higher concentrations of microparticles derived from (activated) platelets/megacaryocytes were present in postmenopausal women taking hormonal replacement therapy. This finding indicates a procoagulant state in these women and might play a role in the development of venous side effects. In contrast, levels of endothelial cell-derived microparticles did not differ.
I852M sequence variations represent genuine RET mutations, falling into ATA class A of weakly activating RET germline mutations.