Do cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology?
Deletion of Cntnap2 impacts similar behaviors and EEG measures in rats and mice, but with profound differences in nature and phenotypic severity. These observations highlight the importance of cross-species comparisons to understand conserved gene functions and the limitations of single-species models to provide translational insights relevant to human diseases.
Genetic variations in glucocorticoid sensitivity and antenatal glucocorticoid treatment are associated with IQ and behavior in young adult preterm survivors.