Do p300 subcomponents reflect different aspects of psychopathology in schizophrenia?
The P300 subcomponents separated with the dipole model are affected in a different manner by positive versus negative symptoms. Furthermore, the positive correlation between the severity of psychopathology and the P300 amplitudes of the different dipole activities appears to be a state-dependent effect, which has to be separated from the P300 amplitude reduction as a trait marker in schizophrenic patients.
Our results indicate that 2-APB treatment effectively alleviates murine AR through pleiotropic activities.