Is foxO3a involved in neutrophil and T cell survival overexpressed in rheumatoid blood and synovial tissue?
The overexpression of FoxO3a in blood from patients with RA, particularly in PMNs, suggests a potential role for this gene in the pathogenesis of RA through increased survival of blood PMNs. In synovium from patients with RA, FoxO3a mainly detected in inflammatory aggregates may also regulate the chronic survival of T lymphocytes.
PB of infected children had increased numbers of colonies, especially in the bacteria-infected group.