Does hemodilution alter the coronary vasodilating effects of endogenous or exogenous nitric oxide?
Series 1: under baseline conditions, hemoglobin in red blood cells does not limit the coronary vasodilatation resulting from tonic release of NO; NO does not mediate coronary vasodilation during ANH. Series 2: ANH does not influence the coronary vasodilating effects of increased levels of NO, whether due to endogenous release (ACh) or infusion of an NO donor (SNP).
Our results provide a useful platform not only for the study of JEV replication, but also for antiviral screening and chimeric vaccine development.