Does insulin-like growth factor-II participate in the biphasic effect of a gonadotropin-releasing hormone agonist on ovarian cancer cell growth?
These data suggest that tryptorelin exerts a bimodal growth effect on ovarian cancer cells by a mechanism involving the autocrine production of IGF-II. The effect of tryptorelin on IGF-II gene transcription in these ovarian cancer cells appears to mirror the desensitizing effects of prolonged GnRH exposure on pituitary gonadotropin production.
CHr, measured simultaneously with Hct, is a sensitive and specific marker of iron status in dialysis patients.