Does a hormone-DNA repair circuit govern the response to genotoxic insult?
The present study identifies for the fi rst time a positive feedback circuit linking hormone action to the DNA damage response and shows the significant impact of this process on tumor progression and therapeutic response. These provocative findings provide the foundation for development of novel nodes of therapeutic intervention for advanced disease.
Our results indicate that Nazca boobies experience life-long consequences of androgenic preparation for an early battle to the death.