Is rectal hyposensitivity uncommon and unlikely to be the central cause of obstructed defecation in patients with high-grade internal rectal prolapse?
Rectal hyposensitivity is relatively uncommon in patients with high-grade internal rectal prolapse and obstructed defecation. Internal rectal prolapse may cause obstructed defecation through a mechanical process. It does not appear that rectal hyposensitivity plays a significant part in the pathological process.
The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.