Does treatment with duloxetine for neuropathic pain impact glycemic control?
Duloxetine treatment was associated with modest changes in glycemia in patients with DPNP. Other metabolic changes were limited and of uncertain significance. These changes did not impact the significant improvement in pain observed with duloxetine treatment.
We conclude that in patients with severe heart failure, NT-pro-BNP has a powerful prognostic value. Patients with high NT-pro-BNP had more than five-fold increase in the 6-month risk of death. Our results do not support the hypothesis that ventricular exhaustion with inability to synthesize and secrete natriuretic peptides is the mechanism underlying decompensation. Attenuation mechanisms of compensatory systems ought to be further studied.