Do the role of electrostatic interactions in governing anesthetic action on the torpedo nicotinic acetylcholine receptor?
Anesthetics representing a wide range of chemical classes reduce the apparent agonist dissociation constant of the Torpedo nicotinic acetylcholine receptor with aqueous potencies that are governed by their molecular volumes and hydrogen bond basicities. However, neither their hydrogen bond acidities nor dipole moments influence aqueous potency.
High P-selectin values indicate activation of platelets and the risk of acute cardiac events in patients with acute coronary syndrome.