Does isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulate arterial contractility?
IP(3) stimulates direct coupling between IP(3)R1 and membrane-resident TRPC3 channels in arterial myocytes, leading to I(Cat) activation and vasoconstriction. Close spatial proximity between IP(3)R1 and TRPC3 establishes this isoform-selective functional interaction.
Early after optic nerve crush, TNFα appears to have a protective role for RGCs, which may be mediated through Müller cells.