Are common polymorphisms of the PPAR-gamma2 ( Pro12Ala ) and PGC-1alpha ( Gly482Ser ) genes associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial?
We conclude that the Pro12Pro genotype of the PPAR-gamma2 gene and the 482Ser allele of the PGC-1alpha gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
Evidently, residence in globally distinct societies helps determine the composition of the gut microbiota that, in turn, influences the production of diet-dependent gut microbial metabolites.