Does xenograft of microencapsulated Sertoli cells restore glucose homeostasis in db/db mice with spontaneous diabetes mellitus?
Preliminarily, xenograft of MC-SC holds promises for an effective cell therapy approach for treatment of experimental T2D.
Extracellularly applied hypericin increased AP duration, which might be ascribed to its effect on I(A) and I(K) currents. As a small increase in AP duration could lead to a dramatic increase in synaptic efficiency, our results imply that hypericin might exert its antidepressant effects by enhancing presynaptic efficiency.