Does candida albicans possess Sap7 as a pepstatin A-insensitive secreted aspartic protease?
We found that Sap7 was a pepstatin A-insensitive protease, and that M242 and T467 restricted the accessibility of pepstatin A to the active site. This finding will lead to the development of a novel protease inhibitor beyond pepstatin A. Such a novel inhibitor will be an important research tool as well as pharmaceutical agent for patients suffering from candidiasis.
We concluded that healing of the burn wound is delayed by preventing NO synthesis.