Is olfactomedin-4 a glycoprotein secreted into mucus in active IBD?
OLFM4 is overexpressed in active IBD and secreted into mucus. The induction is triggered by bacteria through the Notch pathway and also by the cytokine IL-22. OLFM4 seems to be of functional relevance in IBD as a mucus component, possibly by binding defensins.
It is possible that the bone metastatic line CRBM releases factors that induce endothelial cells to favor osteoclast differentiation.