Do plasma factors in severe early-onset preeclampsia substantially alter endothelial gene expression in vitro?
In vitro, plasma from preeclamptic patients does not substantially alter endothelial gene expression profile. Only modest induction of IL-8 gene expression was observed. These results indicate that mechanisms other than soluble plasma constituents are likely involved in systemic endothelial cell activation in preeclampsia.
In the mesopic range, mild hypoxia impairs chromatic sensitivity progressively with reducing luminance. Binocular summation of chromatic signals is consistent and independent of the luminance channel. The CAD test is highly sensitive to mild congenital and acquired color vision deficiencies.