Is localization of the Carnation Italian ringspot virus replication protein p36 to the mitochondrial outer membrane mediated by an internal targeting signal and the TOM complex?
Our results provide insight to how viruses, such as CIRV, exploit specific host-cell protein sorting pathways to facilitate their replication. The characterization of the targeting and insertion of p36 into the mitochondrial outer membrane also sheds light on the mechanisms involved in sorting of host-cell membrane proteins to mitochondria, a process that has been largely unexplored in plants.
There was no bone regeneration in critical defects in 15 days. There was regeneration in the most part of the animals in 30 and 60 days.