Does iGF-2 mediate intestinal mucosal hyperplasia in retinoblastoma protein ( Rb ) -deficient mice?
IGF-2 expression is significantly elevated in villus enterocytes and is required for the hyperplastic intestinal mucosal phenotype of Rb-IKO mice. The trophic effects of IGF2 require intact IGF1R signaling within the intestinal epithelium. These findings reveal novel regulatory roles for Rb in expanding intestinal mucosal surface area.
Our in vitro data support the hypothesis that THL and LEN induce a hypercoagulable state through increased endothelial TF expression.