Does inflammation confer dual effects on nociceptive processing in chronic neuropathic pain model?
The contribution of inflammation to nerve injury is complex with biphasic modulation. During the early phase, a wide range of proinflammatory cytokines are released, leading to enhanced pain. In contrast, the analgesic effect of opioid peptides and antiinflammatory cytokines was more predominate in the later phases of injury, leading to attenuated pain responses.
Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.