Is tamoxifen effective in the treatment of Leishmania amazonensis infections in mice?
Treatment of BALB/c mice infected with L. amazonensis for 15 days with tamoxifen resulted in significant decrease in lesion size and parasite burden. BALB/c mice infected with L. amazonensis represents a model of extreme susceptibility, and the striking and sustained reduction in the number of parasites in treated animals supports the proposal of further testing of this drug in other models of leishmaniasis.
DNMT1 activity appears to positively contribute to the malignancy of HCC cells.