Does 3-Nitropropionic acid depress spinal reflexes involving GABAergic and glycinergic transmission in neonatal rat spinal cord in vitro?
The results indicate that 3-NPA-induced depression of spinal reflexes is partially mediated by GABAergic and glycinergic inhibitory transmission.
These data identify the cartilage proteoglycan degrading metalloproteinase secreted by J774A.1 macrophages in this cell culture model as MME, and describes mechanisms of activation and processing of this enzyme that may play an important role in cartilage degradation.