Does high resolution imaging reveal heterogeneity in chromatin states between cells that is not inherited through cell division?
The directly observed physical separation of reporter loci in live cells is highly dynamic both over time and from cell to cell. However, consistent differences in separation are observed over some chromosomal regions that do not correlate with factors known to influence chromatin states. We conclude that as yet unidentified parameters influence chromatin configuration. We also find that while heterogeneity in chromatin states can be maintained for minutes between cells, it is not inherited through cell division. This may contribute to cell-to-cell transcriptional heterogeneity.
The presence of cloud cover or low solar load does not increase the likelihood of running a fast marathon. The prevailing temperatures during the fastest marathons (approximately 12 degrees C) corroborate previous assertions and seem similar for men and women.