Is human epicardial adipose tissue a source of inflammatory mediators?
Epicardial adipose tissue is a source of several inflammatory mediators in high-risk cardiac patients. Plasma inflammatory biomarkers may not adequately reflect local tissue inflammation. Current therapies do not appear to eliminate local inflammatory signals in epicardial adipose tissue.
Serum HMGB1 is elevated in patients with MG and may play a key role in the inflammation of the neuromuscular junction.