Is genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations associated with leflunomide cessation in rheumatoid arthritis?
A time-to-event model described the time between leflunomide initiation and cessation due to side effects. The C allele of CYP1A2 rs762551 was linked to increased leflunomide toxicity, while no association with teriflunomide exposure was identified. Future research should continue to investigate exposure-toxicity relationships, as well as potentially toxic metabolites.
Collections beyond 15 minutes are necessary to improve accuracy of the ePFT in determining pancreatic exocrine function.