Do upregulation of Caveolin-1 correlate with Akt expression and poor prognosis in NPC patients?
Overexpression of Cav-1 is related to poor prognosis in NPC patients, which correlated with Akt signaling pathway. Abrogation of Akt signaling by shRNA-mediated knockdown of Cav-1 decreased malignant properties of tumor cells. These data suggest the potential for Cav-1 as a possible novel therapeutic target in NPC treatment.
The results suggested that the hypermethylation may lead to promoter silencing of RECK mRNA and associated with poor survival in HCC.