Is intratumoral lymphatic vessel involvement an invasive indicator of completely resected pathologic stage I non-small cell lung cancer?
Our analyses indicate lymphatic vessel involvement as an independent indicator of cancer invasiveness, surpassing the size-dependent tumor, node, metastasis staging system in pathologic stage I non-small cell lung cancer. Patients who would show survival benefits from adjuvant chemotherapy might be found by stratifying prognostic factors.
The results demonstrate a novel, dose-dependent action of MSG in the developing brain, characterized by acceleration of CSD and significant microglial reaction in the cerebral cortex. The CSD effect indicates that MSG can influence cortical excitability, during brain development, as evaluated by CSD acceleration. Data suggest caution when consuming MSG, especially in developing organisms.