Is human papillomavirus DNA detection in ThinPrep Pap test vials independent of cytologic sampling of the transformation zone?
HC2 hrHPV DNA detection in TPPT vials is independent of cytologic sampling of the transformation zone. hrHPV DNA results provide for the first time an available objective basis for risk assessment of patients with no TZ/ECS. The observation that hrHPV DNA test status is independent of presence or absence of a TZ/ECS is consistent with longitudinal studies of Pap negative women with no TZ/ECS which have not found increased disease on follow-up.
In this study we found further evidence for the association of polymorphism in the EGF gene with pre-eclampsia and the weight of babies at birth and identified rs3756261A>G as the SNP that makes the most significant contribution to this association. Bioinformatic analysis showed that this effect may be mediated by caudal type homeohox-2, a transcriptional repressor expressed in the trophoblast, for which a binding site is created at this polymorphic site when the rs3756261A allele is present.