Are attenuation of cardiac dysfunction and remodeling of myocardial infarction by microRNA-130a mediated by suppression of PTEN and activation of PI3K dependent signaling?
miR-130a plays a critical role in attenuation of cardiac dysfunction and remodeling after MI. The mechanisms involve activation of PI3K/Akt signaling via suppression of PTEN expression.
This in vitro analysis suggests that adenosine may stimulate retinal vasculogenesis, an event which involves migration of angioblasts and their assembly into vascular cords, prior to canalization.