Do trains of transcranial direct current stimulation antagonize motor cortex hypoexcitability induced by acute hemicerebellectomy?
The authors' results show that tDCS has the potential to modulate motor cortex excitability after acute cerebellar dysfunction. By putting the motor cortex at the appropriate level of excitability, tDCS might allow the motor cortex to become more reactive to the procedures of training or learning.
A dedicated pharmacokinetics trial for TPs in patients with hepatic impairment is not necessary. Recognizing that the data are very limited, it would be important to continue collecting pharmacokinetic data of TP in patients with hepatic impairment and using population pharmacokinetic analyses to evaluate the effect of hepatic impairment on the pharmacokinetics of TP.