Is upregulation of peroxisome proliferator-activated receptor gamma coactivator gene ( PGC1A ) during weight loss related to insulin sensitivity but not to energy expenditure?
Weight loss upregulates PGC1A, which in turn stimulates MFN2 expression. MFN2 expression significantly and independently contributes to the improvement of insulin sensitivity. UCP3 and CPT1 do not seem to influence energy expenditure after RYGB.
Pokemon exerts its oncogenic activity in the development of HCC by promoting cancer cell growth and reducing apoptosis, and the effect may be mediated by H-ras.