Is the polycomb repressive complex 2 a potential target of SUMO modifications?
Taken together, our data identify sumoylation as a novel post-translational modification of components of the PRC2 complex, which could suggest a potential new mechanism to modulate PRC2 repressive activity. Further work aimed to identify the physiological conditions for these modifications will be required to understand the role of SUZ12 and EZH2 sumoylation in PcG-mediated epigenetic regulation of transcription.
Despite a well-performing TB control programme in the CPY, the number of undetected PTB cases remains unacceptably high. It is doubtful whether TB transmission can be controlled under conditions of confinement, such as the CPY.