Does protein kinase C-δ inactivation inhibit the proliferation and survival of cancer stem cells in culture and in vivo?
These findings suggest that the novel PKC isozyme PKCδ may represent a new molecular target for cancer stem cell populations.
Although the ICA approach primarily detects hidden variables, these surfaced as highly correlated genes in time series data and in one instance in the tumor data. This further strengthens the biological relevance of latent variables detected by ICA.