Does arsenic trioxide inhibit p-glycoprotein expression in multidrug-resistant human leukemia cells that overexpress the MDR1 gene?
As(2)O(3) induces growth-inhibition and apoptosis, down-regulates P-gp expression and exerts a synergistic effect in combination with adriamycin in multidrug-resistant leukemia cells.
These results indicate that the rate of CSF production in patients with PD is normal, and that the rate of CSF production in patients with AD is markedly reduced.