Does zoledronic acid inhibit vasculogenic mimicry in murine osteosarcoma cell line in vitro?
ZA can impair RhoA membrane localization in LM8 cells, causing obvious changes in the ultrastructure of osteosarcoma cells and induce cell apoptosis, which may be one of the underlying mechanisms by which the agent inhibits the development of vasculogenic mimicry by the LM8 cells.
At five years, the local control and disease-free survival for black patients are equally as good as white patients.