Does down-regulation of Transducin-Like Enhancer of Split protein 4 in hepatocellular carcinoma promote cell proliferation and epithelial-Mesenchymal-Transition?
These results demonstrated that TLE4 might play important regulatory roles in cellular proliferation and EMT process in HCC.
The rate of WL (LCD vs VLCD), with similar total WL, strongly regulates AT gene expression. Increased mitochondrial function, angiogenesis and adipogenesis on a VLCD compared with a LCD reflect potential beneficial diet-induced changes in AT, whereas differential neuronal and olfactory regulation suggest functions of these genes beyond the current paradigm.International Journal of Obesity advance online publication, 7 December 2016; doi:10.1038/ijo.2016.201.