Is activation of pp60c-src necessary for human vascular smooth muscle cell migration?
Our findings reveal an association between agonist-induced src activation and chemotaxis. Moreover, an antibody that inhibits src activation dramatically inhibits migration of individual SMC. We conclude that activation of src is necessary for SMC migration. Because of its importance in SMC migration, either molecular or pharmacologic inhibitors of src may be useful in the control of intimal hyperplasia.
Our preliminary study revealed the anti-immobility activity of centrally administered spermine in the FST in mice, with a probable involvement of the polyamine-binding site at the NMDA receptor complex.