Is small intestinal injury in a neonatal rat model of giardiasis strain dependent?
Three genotypically different Giardia isolates that infect neonatal rats with the same trophozoite load differ in their ability to cause functional mucosal damage. Infection with Giardia lamblia induced precocious expression of sucrase activity and impaired mucosal absorption.
Our results highlighted the potential of anti-IGF-1R therapy and the adjuvant therapy strategy with either MEK/ERK inhibitor or metformin to target SCLC, warranting further studies.