Is fgf2 expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour?
Fgf2 expression early in the development of both human and rodent choroid plexus, and its ability to modulate behaviour and gene expression in CPe, supports the view that Fgf signalling plays a role in the maintenance of integrity and function of this specialized epithelium, and that this role is conserved between rodents and humans.
The identified susceptibility genes/loci for adult-onset CD also confer risk for paediatric-onset CD.