Does bumetanide-sensitive cell swelling mediate the inhibitory effect of ethanol on proteolysis in rat liver?
Ethanol causes, via acetaldehyde, bumetanide-sensitive cell swelling, which in turn mediates the antiproteolytic effect of this alcohol. The data indicate the involvement of cell hydration changes in mediating metabolic ethanol effects and could suggest the activation of a putative Na-K-2Cl cotransport in liver by ethanol/acetaldehyde.
These results indicate that hypocapnia during anesthesia causes tissue damage in the caudoputamen, which may be responsible for long-lasting postoperative delirium in patients with stroke and/or dementia.