Does splenectomy attenuate the course of kidney ischemia-reperfusion injury in rats?
The results suggest a detrimental influence of the spleen on the development of renal IRI.
Collectively, our results demonstrate that inefficient heterodimerization appears to be the mechanism by which inactive Taspase1 variants fail to inhibit wild type Taspase1's activity in trans. Our work favours strategies targeting Taspase1's catalytic activity rather than attempts to block the formation of active Taspase1 dimers to interfere with the pathobiological function of AF4•MLL.