Does induction of FLIP expression by androgens protect prostate cancer cells from TRAIL-mediated apoptosis?
Androgenic protection from TRAIL-induced apoptosis is predominantly via enhanced transcription of FLIP in prostate cancer cells. Loss of androgen-sensitivity in ADI prostate cancer cells highlights this pathway as a potential target for future therapy of prostate cancer.
Our observations demonstrate that bladder voiding in healthy infants during sleep is accompanied by body movements and changes in HR and EEG frequency, indicating cortical arousals, whereas during wakefulness these changes cannot be observed.