Is the -308.1 polymorphism in the promoter region of the tumor necrosis factor gene associated with ankylosing spondylitis independent of HLA-B27?
This study confirms the importance of correct matching in genetic analysis in disease association studies, and provides further evidence supporting the involvement of genes other than the MHC class I locus in the pathogenesis and features of AS.
These data add further support for the therapeutic potential of disrupting trk-signaling events in select types of nonneuronal human cancers, specifically prostatic and pancreatic carcinomas.