Does urinary neutrophil gelatinase-associated lipocalin ( NGAL ) distinguish sustained from transient acute kidney injury after general surgery?
Urinary NGAL levels measured 2-3 hr after surgery were able to distinguish the kinetics of creatinine (sustained AKI vs transient AKI) over the subsequent week. Transient AKI is an easily reversible state that is likely not associated with substantial tubular injury and therefore NGAL release. Using AKIN criteria, both transient and sustained AKI are classified as AKI even though our data demonstrates that they are possibly different entities.
Local UVB radiation of the skin influences systemic immune reactions and attenuates systemic autoimmunity via the induction of skin-derived tolerogenic DCs and Tregs. Our data could have implications for the understanding or therapeutic modulation of environmental factors that influence immune tolerance.