Do NSAIDs inhibit growth of precancerous cervical cells in vitro?
Ibuprofen and celecoxib can inhibit growth and induce apoptotic cell death in immortalized cervical cells. results from the present study highlight the need for further in vivo researches and clinical trials in search of novel strategies for cervical cancer prevention.
Upregulation of Nox4 by hypertrophic stimuli and aging induces oxidative stress, apoptosis and LV dysfunction, in part because of mitochondrial insufficiency caused by increased O(2)(-) production and consequent cysteine oxidation in mitochondrial proteins.