Does local inflammation in rat dorsal root ganglion alter excitability and ion currents in small-diameter sensory neurons?
Neuronal inflammation per se, in the absence of nerve injury, causes large increases in Na channel density and enhanced excitability. The unusual finding of increased K current may reflect regulation of excitability in the face of such large increases in Na current.
Our data obtained with invasive measurement of microvascular resistance suggest a significant correlation between cholesterol levels and coronary microvascular dysfunction.