Does dihydrotestosterone enhance castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway?
In CRPC cells, DHT activated STAT5 enhancing cell proliferation. Activation was induced regardless of presence of AR and in cells devoid of AR, DHT used GR which formed direct complex with p-STAT5.
For clinical practice it seems important to check the expectations of the patient, since expectations influence the outcome after MRT.