Does restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occur during postnatal development?
Concordant changes in both lactase mRNA and protein detection during development suggest that the horizontal gradient of lactase enzyme expression is dependent on lactase mRNA abundance. Furthermore, zones of patchy lactase expression appear around weaning and flank the area of high lactase expression in the midintestine. Patchy expression is also found for sucrase-isomaltase before weaning.
After PPPD, most patients have abnormal pyloric function, but it is clinically evident in only a small proportion.