Is major depression associated with significant diurnal elevations in plasma interleukin-6 levels , a shift of its circadian rhythm , and loss of physiological complexity in its secretion : clinical implications?
We report profound morning elevations of plasma IL-6 and a reversal of its circadian rhythm in MDD patients, in the absence of hypercortisolism. These findings may be relevant to the increased risk for coronary heart disease and bone loss in MDD.
Compared to standard electrode placement, wireless pH recording immediately above the SCJ improved the diagnostic performance of esophageal pH monitoring in patients with GERD.