Is adiponectin a potential catabolic mediator in osteoarthritis cartilage?
Adiponectin causes matrix degradation in OA cartilage and increases MMPs and iNOS expression via the AMPK and JNK pathways in human OA chondrocytes. The catabolic effects of adiponectin may be counteracted by NO.
: The findings provide convergent indirect evidence that crying, especially in the first 4 months of age, is an important stimulus for SBS.