Does signaling by SHH rescue facial defects following blockade in the brain?
Collectively, this work suggests that a direct, time-sensitive SHH signal from the brain is required for the later induction of Shh in the FEZ. We propose a testable model of FEZ activation and discuss signaling mediators that may regulate these interactions.
The majority of spiral fractures of the humerus heals after conservative treatment. Early functional treatment is essential for preserving the function of the affected extremity. Surgical treatment should be indicated carefully and the radial nerve should be carefully protected.