Do blood free morphine levels vary with concomitant alcohol and benzodiazepine use?
In the studied cases, the concentrations of BFM were statistically higher when morphine was only isolated in conjunction with benzodiazepines than when combined only with alcohol. These results may be multi-factorial; user error while under drug influence, the individuals drug tolerance, or related to the pharmacokinetics of morphine and its interactions with alcohol and benzodiazepines. Our understanding of the interactions of these substances appears to be far from clear.
We conclude that despite established disease being unaffected by obesity, the early and the resolution phases of RA are impacted by obesity through different mechanisms.