Is cardiac remodeling after myocardial infarction impaired in IGF-1 deficient mice?
IGF-1 deficient mice show preservation of cardiac function 1 week after MI, despite an altered cardiac remodeling process.
These studies are consistent with the hypothesis that the GABAA receptor serves as a major site of action for isoflurane neuroprotection both in vitro and in vivo. However, the mechanism by which this interaction confers in vivo protection cannot be attributed to effects on the duration of ischemic depolarization.