Does mycophenolate mofetil but not atorvastatin attenuate atherosclerosis in lupus-prone LDLr ( -/- ) mice?
The current study demonstrates that reduction of cholesterol levels alone is not atheroprotective in lupus-mediated atherogenesis. This is the first study to demonstrate that MMF reduces the atherosclerotic burden in a model of lupus-accelerated atherosclerosis. Our results suggest that MMF treatment may prove beneficial in preventing CVD in patients with SLE.
The results are discussed in the context of developmental continuity and change in the children's social cognition and voluntary movements.