Does static stretch induce active morphological remodeling and functional impairment of alveolar epithelial cells?
Under static stretch conditions, A549 cells undergo morphological and functional changes. They can survive stress failure from overstretching by remodeling their body to 'escape' the injury. During this complex course of remodeling, cellular function was partly damaged.
the present results show that the combination of the ineffective doses of pindolol and paroxetine significantly increased escape latency, indicating a selective panicolytic effect. These findings give preclinical support for the use of this drug combination in the treatment of panic disorder (PD).