Does changes in the plasma proteome follow chronic opiate administration in simian immunodeficiency virus infected rhesus macaques?
The broad suppressive changes seen in plasma of SIV-infected monkeys likely reflect reduced multisystem immune homeostatic responses induced by opiates. Such occur as a consequence of complex cell-to-cell interactions operative between the virus and the host. We conclude that such changes in plasma proteomic profiling may be underappreciated and as such supports the need for improved clinical definitions.
The educational intervention had no effect on the primary outcome, but decreased the overall prescribing of antibiotics.