Does nicotine increase plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-associated pathway?
Nicotine increases brain endothelial cell PAI-1 mRNA expression and protein production via PK-C-dependent pathway. These findings provide new insights into why smoking may be associated with predisposition to thrombosis and inversely associated with intracerebral hemorrhage after therapeutic tissue plasminogen activator therapy.
Nonselective antagonism of ET receptors attenuates the pulmonary hypertension and blunts the TX-A(2) release caused by massive PAE in dogs.