Does [ The Hsp90 inhibitor FW-04-806 suppress Bcr/Abl-mediated growth of leukemia cells by inhibiting proliferation and inducing apoptosis ]?
Our findings indicate that FW-04-806 displays potential antitumor effect by suppressing the proliferation and apoptosis in Bcr/Abl(+) leukemia cells in vivo.
All of the features associated with mammaglobin expression reflect, without exception, a less aggressive tumour phenotype. Further studies are needed to clarify whether this is attributable to h-MAM expression itself, or to another mechanism of which mammaglobin expression forms part.