Does pPE57 induce activation of macrophages and drives Th1-type immune responses through TLR2?
PPE57 is located on the cell surface and enhances mycobacterium entry into macrophage. PPE57 interacts directly with TLR2 on macrophages. PPE57 plays a key role in the activation of macrophages in a TLR2-dependent manner. PPE57 induces a Th1 immune response via TLR2-mediated macrophage functions. Recombinant BCG over-expressing PPE57 could improve protective efficacy against M. tuberculosis.
To respect donor interests, it is necessary to pay more attention to diversity with regard to biobank types and different contexts for donation. We should avoid assuming that words like 'biobank' and 'donor' can be used in a generic sense - always referring to the same - if we wish to respect and care for the diverse group of individuals who comprise the donating public.