Is angiotensin converting enzyme 2 activity and human atrial fibrillation : increased plasma angiotensin converting enzyme 2 activity associated with atrial fibrillation and more advanced left atrial structural remodelling?
Plasma ACE2 activity is elevated in human AF. Both AF and vascular disease predict elevated plasma ACE2 activity, and elevated plasma ACE2 is significantly associated with more advanced LA structural remodelling.
Our data showed that NLRP1 inflammasome could be activated by extracellular acidosis though ASIC-BK channel K(+) signal pathway and was involved in extracellular acidosis-induced cortical neuronal injury.