Is a 11-year-old tennis player indifferent to competition stress?
The high levels of stress described in adults are not found in young tennis players.
On β-AR activation, reorganization of BIN1-induced microdomains recruits P-RyR into dyads, increasing the calcium transient while preserving electric stability. When BIN1 is reduced as in human acquired heart failure, acute stress impairs microdomain formation, limiting contractility and promoting arrhythmias.