Is filaggrin loss-of-function mutation R501X and 2282del4 carrier status associated with fissured skin on the hands : results from a cross-sectional population study?
Filaggrin loss-of-function mutations seem not only to increase the risk of atopic dermatitis and dry skin but also the risk of fissures on the hands and/or fingers in subjects without atopic dermatitis. Prophylactic emollient therapy should be particularly encouraged in filaggrin loss-of-function mutation carriers.
SUMO modification attenuates the capacity of FXR to function as a transcriptional activator.