Does disruption of Aspm cause microcephaly with abnormal neuronal differentiation?
The results suggested that Aspm is essential to the proliferation and differentiation of neural stem/progenitor cells. The Aspm gene loss model provided a novel pathogenetic insight into acquired microcephaly, which can be caused by in utero exposure to both known and unknown teratogens.
The current study shows some support for the association of neurocognitive biomarkers to depression, though the mechanisms for these relationships are unclear and warrant further investigation.