Does inhibition of hedgehog signal pathway by cyclopamine attenuate inflammation and articular cartilage damage in rats with adjuvant-induced arthritis?
Our findings present some experimental evidence that Hh signal inhibition might be of potential clinical interest in rheumatoid arthritis treatment.
If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting.