Are elevated maternal serum midtrimester alpha-fetoprotein levels associated with fetoplacental ischemia?
Midtrimester amniotic fluid angiogenin levels are significantly elevated in patients with elevated midtrimester maternal serum alpha-fetoprotein levels. Because angiogenin is a known marker of tissue ischemia, resulting in neovascularization, we hypothesize that elevation of maternal serum alpha-fetoprotein levels at triple screen is due to placental ischemia.
The findings support the idea that individual differences in cortisol reactivity can be conceptualised in terms of ineffectual attentional control.