Does bath-PUVA therapy decrease infiltrating CCR4-expressing tumor cells and regulatory T cells in patients with mycosis Fungoides?
Bath-PUVA decreased CCR4(+) cells and Tregs in MF lesions but did not induce circulating Tregs, which might suppress effector T cells. Direct effects through skin lesions might eliminate both pathogenetically relevant cells and Tregs. Systemic immunosuppression was not induced.
SIP is often abnormal in TS and remains unchanged even after successful treatment that was associated with less weight gain and more frequent stool.