Is the A54T polymorphism at the intestinal fatty acid binding protein 2 associated with insulin resistance in glucose tolerant Caucasians?
The A54T polymorphism at the FABP2 locus is a risk factor for insulin resistance in a Caucasian population.
Keratinocytes express abundant HDC protein, and the levels increase in atopic skin. LPS, HDM and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes. Actively produced histamine influences keratinocyte differentiation, suggesting functional relevance of the axis to atopic dermatitis. The findings therefore identify a new point of therapeutic intervention.