Does chronic infusion of low-dose angiotensin II potentiate the adrenergic response in vivo?
Thus, although the direct contractile responses to potassium and angiotensin II remain unaffected following chronic angiotensin II treatment, the alpha 1-adrenergic contractile response to phenylephrine is significantly potentiated by angiotensin II in this model of hypertension. We suggest that this potentiation contributes to the hypertension observed in response to infusion of low-dose angiotensin II.
The structural perturbation of the end plate/IVD, but not the loading energy or nuclear depressurization, promotes DD. In addition, end-plate puncturing triggers a different pathogenesis, consistent with a more continuous matrix remodeling process.