Does transdermal estradiol treatment suppress serum gonadotropins during lactation without transfer into breast milk?
A dose as high as 100 microg/24 hours of E(2) can be administered transdermally without traces appearing in the breast milk. Whether the symptoms associated with the hypoestrogenic state of lactation can be alleviated by transdermal E(2) treatment (50 or 75 microg/24 hours) can now be studied in the early postpartum phase (6 weeks onward).
The data show that neutrophil apoptosis is delayed in horses following the induction of colitis, due to interference with the intrinsic and extrinsic apoptotic pathways, which may contribute to the development of equine SIRS. Concurrent development of neutrophilia may contribute to prolonged neutrophil lifespan through a concentration-dependent delay in apoptosis. This article is protected by copyright. All rights reserved.