Are fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide ( GIP ) and glucagon-like peptide-1 ( GLP-1 ) highly familial traits?
Our results suggest that circulating levels of GIP and GLP-1 as well as beta cell response to these incretins are highly familial compared with more commonly investigated measures of glucose homeostasis such as fasting and stimulated plasma glucose, serum insulin and serum C-peptide.
We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.