Is sequence variation among members of the miR-200 microRNA family correlated with variation in the ability to induce hallmarks of mesenchymal-epithelial transition in ovarian cancer cells?
Our results indicate that although ectopic overexpression of all members of the miR-200 family in mesenchymal-like OC cells results in morphological changes characteristic of MET, the underlying molecular changes and induced drug sensitivities are highly variable and correlated with sequence variation within the seed and non-seed regions of individual family members.
Our study thus highlights a pivotal role of TIMP-1 in urethral scar formation.