Is a dysregulation in CES1 , APOE and other lipid metabolism-related genes associated to cardiovascular risk factors linked to obesity?
Different expression patterns in transcripts encoding for proteins involved in lipolysis and lipoprotein metabolism were found between lean and obese subjects. Moreover, the dysregulation of genes such as CES1 and APOE seems to be associated with some physiopathological markers of insulin resistance and cardiovascular risk factors in obesity.
Reasons for this relapse in condom use in the general population include changes in social and individual representation due to the introduction of highly active antiretroviral therapy, the difficulties in sustaining long-term preventive behaviours, and a high level of awareness in the population and/or the decrease of large HIV prevention campaigns.