Do phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production?
The data suggest that the displacement of beta PP away from the cell surface after phorbol ester treatment reduces the substrate available for endocytic processing and in turn, results in the inhibition of A beta production.
Balance impairment does not necessarily coexist with gait apraxia. Gait apraxia is more prevalent in moderate AD when compared with mild AD.