Is routine prophylactic central neck dissection for low-risk papillary thyroid cancer cost-effective?
TT with CND is not a cost-effective strategy in low-risk PTC. Initial TT alone is favourable because of the low complication rates and low recurrence rates associated with the initial surgery. Alternative strategies such as unilateral prophylactic neck dissection require additional study to assess their cost-effectiveness.
These results indicate that the MafA PTD could serve as a therapeutic delivery vehicle, and further suggest that MafA protein transduction could be a valuable strategy for enhancing insulin gene transcription without requiring gene transfer technology.