Is myocardial Production of Plasminogen Activator Inhibitor-1 Associated with Coronary Endothelial and Ventricular Dysfunction after Acute Myocardial Infarction?
PAI-1 produced in the infarcted myocardium and released into the coronary circulation is associated with endothelial dysfunction in resistance vessels of the infarct-related coronary arteries and with progressive dysfunction of the infarcted region of the left ventricle in AMI survivors.
Our results suggest that there may be a biological effect of very young maternal age, affecting foremost very preterm birth.