Is urinary human L-FABP a potential biomarker to predict COX-inhibitor-induced renal injury?
Urinary L-FABP is capable of revealing chronic renal injury induced by COX inhibitors.
Taken together, our results suggest that beta-cells secrete microRNAs that can be transferred to neighboring beta-cells. Exposure of donor cells to pathophysiological conditions commonly associated with diabetes modifies the release of microRNAs and affects survival of recipient beta-cells. Our results support the concept that exosomal microRNAs transfer constitutes a novel cell-to-cell communication mechanism regulating the activity of pancreatic beta-cells.