Does transcriptome and methylome profiling reveal relics of genome dominance in the mesopolyploid Brassica oleracea?
Differential expression of the triplicated syntelogs and cytosine methylation levels across the sub-genomes suggest residual marks of the genome dominance that led to the current genome architecture. Although cytosine methylation does not correlate with individual gene dominance, the independent methylation patterns of triplicated copies suggest epigenetic mechanisms play a role in the functional diversification of duplicate genes.
Normal ageing leads to impaired RV relaxation with a reduction in E' velocity and amplification of the atrial component (A') without a change in overall RV volume or systolic function.