Is interferon regulatory factor 9 a key mediator of hepatic ischemia/reperfusion injury?
IRF9 has a novel function of inducing hepatocyte apoptosis after I/R injury by decreasing SIRT1 expression and increasing acetyl-p53 levels. Targeting IRF9 may be a potential strategy for ameliorating ischemic liver injury after liver surgery.
Akt activation seems more sensitive to active contractile tension than to passive tension. Activation frequency seems to play no role in the phosphorylation of Akt.