Does in vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveal increased pyruvate carboxylase flux in an insulin-resistant mouse model?
Taken together, we demonstrate that increased PC flux is an important pathway responsible for increased HGP in diabetes development, and that pharmacologically induced metabolic changes specific to the liver can be detected in vivo with a hyperpolarized (13)C-biomolecular probe. Hyperpolarized (13)C MRS and the determination of metabolite exchange rates may allow longitudinal monitoring of liver function in disease development.
Even extended pulmonary resections for non-small cell lung cancer are feasible in the elderly. Long-term survival is obtainable. Tumor stage does not seem to play a role with regard to survival provided that complete resection of the tumor in anatomic units with systematic, extensive lymph node dissection is performed. Further investigations are necessary to prove this hypothesis in larger series.