Does [ 8-Chloro-adenosine increase the activity of transcription factor CREB by modification of phosphorylation ]?
The increase of transcriptional activity of CREB induced by 8-Cl-Ado depends on the increased level of phosphorylated CREB, but is not associated with the protein level and DNA binging level of CREB.
These are the first studies to demonstrate progression of inflammatory plaque accumulation in the innominate arteries by in vivo MRI analysis following pathogen exposure, and to document protection from plaque progression in the innominate artery via immunization.