Does poly ( ADP-ribose ) polymerase-2 depletion reduce doxorubicin-induced damage through SIRT1 induction?
Our data identify PARP-2 as a mediator of DOX toxicity by regulating vascular SIRT1 activity and mitochondrial biogenesis. Moreover, to the best of our knowledge, this is the first report of SIRT1 as a protective factor in the vasculature upon oxidative stress.
Adiponectin plays a protective role in caerulein-induced AP in HFD-fed mice.