Is effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene expression in human adipose tissue limited by antiretroviral drug-induced mitochondrial dysfunction?
These data suggest that in HIV-infected, lipoatrophic men, adipose PPARG expression and function are dependent on intact mitochondrial function. These data support a direct link between mitochondrial toxicity and adipose tissue PPARG expression and help explain the poor clinical response to RSG observed in clinical trials.
A relatively elevated MacNew global score appears to be associated with a significantly decreased risk of unscheduled hospitalizations after coronary revascularization over a 3-year follow-up.