Do polymorphisms of cell cycle control genes influence the development of sporadic medullary thyroid carcinoma?
In summary, we demonstrated that CDKN1B and CDKN2A genes are associated with susceptibility, whereas the inherited genetic profile of CDKN1A, CDKN2B, and CDKN2C is associated with aggressive features of tumors. This study suggests that profiling cell cycle genes may help define the risk and characterize s-MTC aggressiveness.
The development of cardiac dyssynchrony correlates with adverse left ventricular remodeling after MI .