Is genetic polymorphism related to exfoliative glaucoma also associated with primary open-angle glaucoma risk?
This polymorphism seems to be associated with high risk for primary open-angle glaucoma in a Mediterranean population.
This is the first demonstration of disassembly of RR structures upon microinjection of anti-IMPDH2 antibodies that led to the disappearance of the molecular aggregates. The disassembly of RR after microinjection of anti-IMPDH2 antibody further strengthens the notion that IMPDH2 are major building blocks of RR. Using two independent methods, this study demonstrated that the induced RR are primarily stationary structures in live cells and that IMPDH2 is a key component of RR.