Is re-epithelialization from human skin explant cultures promoted by ligand-activated HER3 receptor?
The study emphasizes the central role of EGFR in epidermal renewal and demonstrates that HRG-activated HER3 contributes to the outgrowth process of epidermis in vitro.
GTPCH expression is tissue specific. Different tissues react differently to endotoxemia in terms of GTPCH expression. Therefore, efforts aiming at modulating GTPCH expression to limit NO overproduction should adjust accordingly.