Is tumor-stroma interaction of human pancreatic cancer : acquired resistance to anticancer drugs and proliferation regulation dependent on extracellular matrix proteins?
ECM proteins have important roles in acquired resistance to anticancer drugs and cell proliferation regulation of pancreatic cancer cells. Therefore, the expression of ECM proteins in pancreatic cancer specimens could provide valuable information to aid anticancer drug cytotoxicity, and gemcitabine would be useful for treatment of patients with pancreatic cancer.
LC endocytosis leads to production of inflammatory cytokines through activation of NF-kappaB. This may be an important mechanism of chronic tubulointerstitial inflammation process commonly seen in multiple myeloma. These findings also point out a potential role by filterable low-molecular-weight proteins, like LCs, in PTC injury during all proteinuric diseases.