Does periodic mechanical stress stimulate the FAK mitogenic signal in rat chondrocytes through ERK1/2 activity?
Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin β1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin β1-FAK (Tyr(397))-ERK1/2.
Statins increase expression of mdr2 and mdr1b in rats, revealing a novel effect of these commonly used drugs.