Polymorphic light eruption and skin cancer prevalence: is one protective against the other?
Our results show (i) strong evidence of reduced PLE in patients with SC, and (ii) a trend for reduced SC in patients with PLE. The immunological basis of PLE may therefore confer protection against SC.
We conclude (1) the existence of a tight crosstalk of TGF-β and BMP2 pathways in HSCs and (2) a Smad7 dependently decreased sugar metabolism ameliorates HSC activation probably by energy withdrawal.