Is small cell lung cancer growth inhibited by miR-342 through its effect of the target gene IA-2?
Our studies show for the first time that both miR-342 and its target gene IA-2 are involved in the growth process of SCLC cells and act by their effect on autocrine secretion. These findings point to possible new therapeutic approaches for the treatment of autocrine-induced tumor proliferation.
The mechanism(s) conferring deltamethrin resistance remain unknown at present but are likely to extend to other synthetic pyrethroids approved for use against this species. The findings suggest that these compounds are unlikely to give satisfactory control of T. tabaci in England and have stimulated the recommendation to use alternatives.