Is defective killing of Staphylococcus aureus in atopic dermatitis associated with reduced mobilization of human beta-defensin-3?
Patients with AD have problems with S. aureus skin infection. This is a result of increased levels of T(H)2 cytokines, which inhibit keratinocyte mobilization of HBD-3.
Children demonstrate high rates of inhibition (SD) and overactivation (HF) of fibrinolysis after injury. SD and HF are both associated with poor outcomes. Shutdown is a particularly poor prognostic indicator, accounting for the greatest percentage of death, disability and patients requiring transfusion as well as later development of hypercoagulable state. The addition of TEG to pediatric trauma care protocols should be considered as it contributes important prognostic and clinical information.