Is transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide critical to trigger pain during monosodium urate-induced inflammation in rodents?
Our results suggest that MSU injection increases tissue H2 O2 , thereby stimulating TRPA-1 on sensory nerve endings to produce inflammation and nociception. TRPV-1, by a previously unknown mechanism, also contributes to these responses.
'Do Not Resuscitate' orders appeared twice as frequently in elderly patients (>or = 70 yr). However, the proportions of deaths without cardiopulmonary resuscitation and the organ failure scores between age groups were similar suggesting that severity of illness was more important than age in determining resuscitation status.