Is the insulin-signaling pathway of the pancreatic islet impaired in adult mice offspring of mothers fed a high-fat diet?
The present study demonstrated that a maternal HF diet is responsible for remodeling the islet structure coupled with an adverse carbohydrate metabolism and impairment of the insulin-signaling pathway in adult male mice offspring.
Lumiracoxib is as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile.