Does topiramate alter expression in rat brain of enzymes of arachidonic acid metabolism?
These results suggest that topiramate does not modify expression of the enzymes involved in brain AA metabolism that have been shown to be targeted by lithium, valproic acid, or carbamazepine. If topiramate proves effective in bipolar disorder, it may not act by modulating brain AA metabolism. In view of the proven anticonvulsant effect of topiramate, our results also suggest that the AA cascade is not involved in the anti-seizure properties of the drug.
Neonatal birth weight is not correlated with a dye-determined or ultrasound estimated amniotic fluid volume.