Does a point mutation in Sec61alpha1 lead to diabetes and hepatosteatosis in mice?
Here we phenotypically characterize diabetes in mice with a novel point mutation in a basic component of the cell's ER protein translocation machinery, Sec61alpha1. Translocation by the mutant protein does not appear to be affected. Rather, ER homeostasis is perturbed leading to beta-cell death and diabetes.
The use of bilateral ilioinguinal nerve block for postoperative analgesia after hysterectomy decreased morphine consumption by one-half during the first two postoperative days without differences in side effects from morphine between groups.