Do cell-cell contacts prevent anoikis in primary human colonic epithelial cells?
Integrity of cell-cell contacts compensates for the loss of cell-matrix contact-mediated survival signals in CECs and prevents apoptosis. Cell-cell contact-triggered CEC survival involves antiapoptotic signaling through beta-catenin-, Src-, and PI3-K/Akt- but not through MEK- and focal adhesion kinase-dependent pathways.
In a rabbit model, a "proof of principle" was demonstrated that topical antibiotic therapy pre- and postintraocular bacterial challenge could prevent bacterial endophthalmitis. Surgical prophylaxis with topical 0.5% moxifloxacin (Vigamox) may prove to be a valuable adjunct for the prevention of endophthalmitis.