Is elevated expression of prostate cancer-associated genes linked to down-regulation of microRNAs?
The findings of this study indicate that the expression of specific miRNAs is decreased in PCa and inversely correlates with the up-regulation of their putative target genes. Consequently, miRNAs could contribute to oncogenesis and progression of PCa via an altered miRNA-target gene-interaction.
These data may provide an explanation for partial protection against postarrest myocardial dysfunction provided by adenosine.