Does gene transfer of heat-shock protein 70 reduce infarct size in vivo after ischemia/reperfusion in the rabbit heart?
Direct gene delivery of HSP 70 in vivo reduces the severity of ischemic injury in the heart.
Among HIV-infected patients with poor cellular immunity, infection with multiple strains of M. tuberculosis was found in half of the patients. In those patients with identical strains, whole genome sequencing indicated that M. tuberculosis intra-patient microevolution does occur in a few patients, yet did not reveal a consistent direction of spread between sputum and blood. This suggests that these compartments are highly connected and potentially seed each other repeatedly.