Is paired box gene 8 ( PAX8 ) expression associated with sonic hedgehog ( SHH ) /wingless int ( WNT ) subtypes , desmoplastic histology and patient survival in human medulloblastomas?
In summary, high PAX8 expression is linked to better prognosis in MBs potentially by suppressing both proliferative and migratory properties of MB cells. The distinct spatio-temporal expression pattern of PAX8 during brain development might contribute to the understanding of distinct MB subtype histogenesis.
Our results suggest that DB extract may prevent HFD-induced obesity by downregulating the expression of genes related to adipogenesis and inflammation in visceral adipose tissue.