Does sodium selenite inhibit interleukin-6-mediated androgen receptor activation in prostate cancer cells via upregulation of c-Jun?
Taken together, our results suggest that sodium selenite not methylseleninic acid can inhibit IL-6-mediated AR activation by increased c-Jun in LNCaP cells. Sodium selenite may be a proper selenium form for further testing its potency on intervening IL-6-mediated PCa progression.
Our results clearly show the involvement of superoxide (supplied by paraquat and/or induced with mitogens) in physiological responses such as proliferation and apoptosis. Such divergent responses should be explained in terms of our dose-response observations.