Does osteopontin-deficiency suppress growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures?
Osteopontin deficiency reduced the bone loss caused by tumor cell implantation into the bone marrow space.
We believe that hyperinflation plays a major role in inspiratory muscle dysfunction in asthma, but the finding of significantly decreased PImax values in steroid-dependent asthmatics when compared with patients on high-dose inhaled beclomethasone with a comparable level of hyperinflation points to a deleterious effect of long-term, moderate-dose systemic corticosteroid but not high-dose beclomethasone on inspiratory muscle function in asthmatics.