Is etoposide resistance in MCF-7 breast cancer cell line marked by multiple mechanisms?
This study sheds light into the etoposide resistance in breast cancer by investigating previously proposed and novel factors that may have a role in development or progression of etoposide resistance which can be considered as diagnostic markers and therapy targets.
Inhibition of LSA neurotransmission reduced the MAP and HR increases observed during RS. However, no changes were observed in the decrease in skin temperature and increase in internal body temperature observed during this period. Also, LSA inhibition did not change the anxiogenic effect induced by RS observed 24 h later in the EPM. The present results suggest that LSA neurotransmission is involved in the cardiovascular but not the temperature and behavioral changes induced by restraint stress.