Is a stable CC-chemokine receptor ( CCR ) -5 tropic virus correlated with the persistence of HIV RNA at less than 2.5 copies in successfully treated naïve subjects?
The tropism of archived virus was stable during an effective treatment, with 15-18% of subjects switching over time, despite a viraemia<50 copies/ml. R5 tropism and its stability were related to achieving and maintaining viraemia<2.5 copies/ml.
These novel findings may have implications for the design of therapeutic regimens which exploite the immune system in sarcoma patients by combining standard radiotherapy with immunotherapeutic strategies.