Is γ-Tocotrienol a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma : potential role as an antiproliferative , pro-apoptotic and chemosensitizing agent?
Overall, these results suggest that γ-tocotrienol is a novel blocker of the STAT3 activation pathway, with a potential role in future therapies for HCC and other cancers.
Nuclear PG provokes adipogenesis in c-Kit+ CPCs by repressing the canonical Wnt signaling and inducing a proadipogenic gene expression. The findings suggest that adipocytes in ARVC, at least in part, originate from c-Kit+ CPCs.