Does tissue inhibitor of metalloproteinase-2 inhibit burn-induced derangements and hyperpermeability in microvascular endothelial cells?
Burns may lower TIMP-2 levels and increase MMP activity and that TIMP-2 application in vitro may attenuate burn-induced hyperpermeability and decreases damage to endothelial structural proteins. These links warrant further investigation.
The possibility of generating HSEs with different cell types represents an attractive approach for in vitro studies focusing on the mechanism of wound healing.