Do bax and Bak exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa?
The data indicate that Bax and Bak have nonredundant functional roles in the apoptotic response of the irradiated intestinal endothelium. The observation that Bax deficiency and Bak deficiency also protect crypts in the microcolony assay provides strong evidence that the microvascular apoptotic component is germane to the mechanism of radiation-induced damage to mouse intestines, regulating reproductive cell death of crypt stem cell clonogens.
Performing routine lumbar punctures may still have a role to play in the management of children with febrile seizures.