Does azimilide inhibit multiple cardiac potassium currents in human atrial myocytes?
The present study provides direct evidence that azimilide inhibits multiple cellular transmembrane K(+) currents in freshly isolated human atrial myocytes. Inhibition of these K(+) currents by azimilide, especially of I(Ks) and I(Kur) is likely to be the electrophysiologic basis for the prolongation of the action potential duration in the human atria which mediates its known antifibrillatory effects in atrial fibrillation and flutter.
Self-reported measures were used, anxiety was not evaluated and 17 subjects were lost to follow up.