Does aqueous extract of Lithospermi radix attenuate oxaliplatin-induced neurotoxicity in both in vitro and in vivo models?
In conclusion, we demonstrated that WLR can attenuate OXIPN in both in vitro and in vivo experimental models, which may be in part attributed to its anti-inflammatory activity in the spinal cord and its neuroprotective potential in the peripheral nerve system without affecting the anti-tumor potential of oxaliplatin. Therefore, WLR could be considered as a good starting material to develop a novel therapeutic agent targeting OXIPN. However, further studies should be done to elucidate the underlying mechanism such as molecular targets and active constituent(s) in WLR with neuroprotective potential.
Environmental factors and bacterial viability are important factors which influence the ability of both cytotoxic and invasive strains of P. aeruginosa to bind to the scarified cornea.