Does intracerebroventricular administration of metformin inhibit ghrelin-induced Hypothalamic AMP-kinase signalling and food intake?
Metformin could reduce food intake by preventing ghrelin-induced AMPK signalling and mTOR inhibition in the hypotalamus.
Epidural placement before engagement of the fetal head is associated with an increased incidence of malposition at delivery. This finding may provide an insight into the empiric observation that operative delivery is variably increased for patients laboring under epidural anesthesia.