Do patients with unstable slipped capital femoral epiphysis have antecedent symptoms?
Patients who sustained unstable SCFEs had premonitory pain in the limb. Early recognition and an appropriate diagnosis provide a critical opportunity to prevent a morbid unstable SCFE.
Response to hyperammonemia is reminiscent of the cellular response to amino acid starvation, but lacks the adaptive ATF4 dependent integrated stress response (ISR). Instead, hyperammonemia-induced l-leucine uptake was an adaptive response to the GCN2-mediated decreased protein synthesis.