Is 21-Hydroxylase-deficient nonclassic adrenal hyperplasia a progressive disorder : a multicenter study?
In children <10 years old the most common presenting complaint was premature pubarche, whereas hirsutism and oligomenorrhea were more common in older patients. The prevalence of hirsutism increased with age, suggesting the progressive nature of nonclassic adrenal hyperplasia. Furthermore, the adrenocorticotropic hormone-stimulated levels of 17-hydroxyprogesterone were higher in patients with clitoromegaly, which suggests that the degree of adrenocortical dysfunction in nonclassic adrenal hyperplasia determines, at least in part, the clinical presentation.
Studies that focus on QoL of dialysis patients are rare in Africa. This one showed an impaired QoL, especially for physical health, among our hemodialysis patients.