Are soluble intercellular adhesion molecule , vascular cell adhesion molecule , and impaired microvascular reactivity early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria?
Multiple markers of endothelial dysfunction were evident in normoalbuminuric individuals with type 2 diabetes. The pathogenic process of vasculopathy in type 2 diabetes occurs early and may be operative before the development of microalbuminuria.
The number of GalNAc attached in the IgA O-linked glycans of CD patients was significantly decreased, and strongly correlated with the clinical activity. Alterations of GalNAc attachment in IgA could be useful as a novel diagnostic and prognostic marker of CD.