Does 18F-FDG PET/CT identify patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease?
In a large cohort of cancer patients, increased (18)F-FDG uptake in major arteries emerged as the strongest predictor of a subsequent vascular event. Concomitant severe vascular calcifications seemed to impart a particularly high risk. Given the small event rate in the present study, larger, prospective trials of patients without cancer are required to substantiate these promising results.
This study suggests that exon-8-skipped truncated kindlin-1 is functionally defective and does not compensate for the defects of KS, even though kindlin-1 expression in skin is positive.