Does the surgical approach affect quality of life outcomes?
Minimally invasive parathyroidectomy is associated with a greater improvement in post-operative quality of life than the open technique despite the fact that both result in equivalent normalisation of serum calcium levels. It is not clear if this is due to differences in the technique itself or is related to the patients' perceptions of having had a "less invasive" surgical procedure.
Therapeutic options for patients with FNS include surgical intervention, observation and radiotherapy. Nowadays, surgical resection with facial nerve repair is usually the standard management for patients with poor facial function (House-Brackmann grade III or worse). In patients presenting with normal or near-normal facial nerve function, initial observation with periodic examination and imaging is usually recommended. However, on rare occasions surgeons can be faced with a situation in which the management decision-making process is particularly challenging. In these complex cases treatment should be individualized. We recommend early surgical intervention regardless of the preoperative facial and hearing functions in the following cases: intratemporal FNSs extending with a large tumor component into the parotid, multiple-segment FNSs extending in both the cerebellopontine angle and the middle cranial fossa, fast-growing FNSs, and large FNSs with temporal lobe compression.