Is low ejection fraction documented during cardiac catheterization significantly associated with long-term , all-cause mortality?
Decreased EF measured during coronary angiography is a strong independent predictor of all-cause mortality over a period of 10 years.
This study provides the first molecular and functional evidence implicating a GJA1 mutation as a novel pathogenic substrate for SIDS. E42K-connexin43 demonstrated a trafficking-independent reduction in junctional coupling in vitro and a mosaic pattern of mutational DNA distribution in deceased cardiac tissue, suggesting a novel mechanism of connexin43-associated sudden death.