Does bumetanide reduce seizure progression and the development of pharmacoresistant status epilepticus?
Our data demonstrate an anticonvulsant effect of bumetanide on KA-induced seizures in adult mice, suggesting a role for chloride plasticity in seizure progression. These data also demonstrate that the erosion of inhibition during seizure progression could underlie the development of pharmacoresistant SE and implicate a role for chloride plasticity in this process.
In selected patients with ACC LM, resection is associated with long-term survival and is, therefore, justified but rarely curative.