Does autotaxin Inhibition with PF-8380 enhance the Radiosensitivity of Human and Murine Glioblastoma Cell Lines?
Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. These results suggest that inhibition of ATX may ameliorate GBM response to radiotherapy.
MNTX-PC formulation significantly enhanced the oral bioavailability of MNTX.