Does loss of sclerostin promote osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways?
Sclerostin may play an important role in maintaining cartilage integrity in OA.
Our data identify S3 and S4 as transmembrane proteins specifically enriched in Schwann cell perinodal processes, and suggest that S3 may be involved in early axoglial interactions during development.