Does corticotropin-releasing factor-1 receptor activation mediate nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse?
These studies indicate that CRF(1) receptors but not CRF(2) receptors play an important role in the anhedonic-state associated with acute nicotine withdrawal and stress-induced reinstatement of nicotine-seeking.
The plaque formation/morphology may depend on local environment and is independent of oxidative stress/inflammation observed on the level of the whole body.