Does oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides lead to control of Cryptosporidium parvum infection in neonatal mice?
The control of neonatal C. parvum infection by ip or oral administration of ODNs is feasible by 2 different mechanisms: (1) the well-known interaction involving CpG/TLR9, leading to the production of cytokines and lymphocyte activation, and (2) a new unknown mechanism that is independent of TLR9 and effective orally.
The time of hospitalization is a potential "golden opportunity" to counsel patients and promote colon cancer screening.