Does botulinum toxin type A reduce histamine-induced itch and vasomotor responses in human skin?
BoNT/A reduced the itch intensity, blood flow and neurogenic inflammation in response to the histamine prick test in human skin. The findings could be applicable in the treatment of some pruritic conditions that can be difficult to treat with conventional treatments.
We conclude that ATRA can modulate protease/antiprotease balance in a manner that may impact on disease pathogenesis.