Does hypercholesterolemia promote early renal dysfunction in apolipoprotein E-deficient mice?
These data show that both hypercholesterolemia and aging contribute to the loss of renal function in mice.
The SNP rs7848647 associated with the TNFSF15 gene is associated with surgical diverticulitis. This finding suggests a fundamental role for TNFSF15, a T-cell receptor gene involved in T-cell maturation, in the pathophysiology of diverticulitis requiring surgery. This SNP may be a marker of diverticular disease severity that might assist in surgical decision making.