Does oxidative stress affect the junctional integrity of retinal pigment epithelial cells?
Increased resistance to chronic oxidative stress with differentiation in ARPE-19 cells correlated with higher steady state levels of Hsp27 and Hsp70. Oxidative stress disrupted RPE cell junction and barrier integrity, which may contribute to the pathogenesis of diseases related to RPE through disruption of the blood-retinal barrier.
Given current resources, we cannot reliably meet established documentation standards for high-risk pregnancies. Such overly stringent documentation standards pose a significant risk in cases going to litigation. A standard should be developed that is based on outcome data.