Is treatment with tissue plasminogen activator associated with increased use of neurosurgery?
In this large sample of US hospital admissions as a result of acute ischemic stroke with overlapping hemorrhage, the use of rtPA was not associated with an increased number of neurosurgical interventions. This lack of association, which needs to be confirmed in prospective studies, argues against withholding treatment with rtPA in patients with stroke based on neurosurgical availability.
DETT displays a promising potential for MM therapy as an inhibitor of the NFκB signalling pathway.