Is polymorphism of A133S and promoter hypermethylation in Ras association domain family 1A gene ( RASSF1A ) associated with risk of esophageal and gastric cardia cancers in Chinese population from high incidence area in northern China?
The present findings suggest that alterations of RASSF1A may play an important role in gastric cardia carcinogenesis in terms of polymorphism, promoter hypermethylation and protein expression. Whereas, RASSF1A hypermethylation may probably also be involved in esophageal squamous cell carcinogenesis.
Intraamniotic furosemide injection caused a substantial decrease in ID encountered in gastroschisis. The induction of fetal diuresis with intraamniotic furosemide injection seems promising as a prenatal treatment modality.