Is liver kinase B1 expression ( LKB1 ) repressed by estrogen receptor alpha ( ERα ) in MCF-7 human breast cancer cells?
ERα repressively modulates the expression of LKB1 at the transcriptional level. Targeting the expression of LKB1 by modulating ERα signaling may provide a potential approach to further evaluate its function in ERα-positive breast cancers.
PEM is capable of differentiating breast tumours from benign lesions with 100% sensitivity along with a high specificity of 96%, when a threshold of PUVmax>1.9 is applied.