Does deletion of CCR2 but not CCR5 or CXCR3 inhibit aortic aneurysm formation?
The CCR2 receptor is involved directly in AAA formation, whereas the CCR5 and CXCR3 receptors are not.
Statins and PGJ(2), but not TZDs, prevent the development of a PTEC pro-inflammatory phenotype in response to albumin. Albumin endocytosis is not a prerequisite for PTEC chemokine production, and inhibition of albumin endocytosis alone is insufficient to attenuate chemokine production. These studies suggest a therapeutic role for statins and some PPARgamma ligands in proteinuric renal disease.