Does endotoxin release a precursor to vasodilation from large veins in an NF-kappaB-dependent manner?
These results show that the vena cava is capable of releasing a factor leading to vasodilation in response to ET in a manner similar to the aorta. Produced by the veins, it will affect venous capacitance as well as contribute to the total amount in the plasma pool affecting the tone of the resistant arterioles. Thus, it appears that these large conducting vessels, regardless of origin, play a role in the deleterious effects during septic events.
Treatment with the delta opioid agonist DADLE increases ischemic tolerance of isolated rabbit jejunum.