Does sLCO1B1 gene variability influence lipid-lowering efficacy on simvastatin therapy in Southern Brazilians?
The present study suggests that the SLCO1B1 c.388A>G polymorphism could play a role in the inter-individual variation of clinical response to simvastatin in Brazilians. These results add to those that suggest that the effects of SLCO1B1 variants may be statin specific.
Both factors suggest that evidence plays a role in the decision-making process.