Is transcriptional upregulation of microtubule-associated protein 2 involved in the protein kinase A-induced decrease in the invasiveness of glioma cells?
Our findings suggested that PKA may represent a potential target for anti-invasion glioma therapy and that the downstream modulators (eg, STAT3/MAP2) partially mediate the effects of PKA.
These results indicate inherent characteristics of adipocytes, including size and lipolytic activity, may be important determinants of whole-body lipid oxidation and subsequent weight gain.