Does loss of pim1 impose a hyperadhesive phenotype on endothelial cells?
Loss of Pim1 induces a strong adhesive phenotype by enhancing endothelial cell-cell and cell-matrix adhesion by the deposition of a specific extracellular matrix. Targeting PIM1 function therefore might be important to promote endothelial barrier integrity.
Genetic polymorphisms in ERCC1 may be valuable predictors of cisplatin-induced nephrotoxicity.