Does microneedle pretreatment enhance the percutaneous permeation of hydrophilic compounds with high melting points?
Commercially available microneedle rollers with 200-300 μm long needles enhance the drug delivery of topically applied non-steroidal anti-inflammatory drugs and represent a valuable tool for percutaneous permeation enhancement particularly for substances with poor permeability due to a hydrophilic nature and high melting points.
We suggest the use of Pt/Ir electrodes for IOM in 1.5-T iMRI suites.