Is aBCC6-mediated ATP secretion by the liver the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report?
Hepatic ABCC6-mediated ATP release is the main source of circulating PPi, revealing an unanticipated role of the liver in systemic PPi homeostasis. Patients with PXE have a strongly reduced plasma PPi level, explaining their mineralization disorder. Our results indicate that systemic PPi is relatively stable and that PXE, generalized arterial calcification of infancy, and other ectopic mineralization disorders could be treated with PPi supplementation therapy.
The therapeutic effects of HBO on subjective tinnitus may be substantially influenced by psychological mechanisms.