Is sustained weight loss after Roux-en-Y gastric bypass characterized by down regulation of endocannabinoids and mitochondrial function?
The attenuated caloric intake, reduced food efficiency, and normalization of hormonal levels on day 28 post-RYGB were associated with significant down-regulation of endocannabinoids anandamide and 2-arachidonoylglycerol in muscle and liver, respectively. These results suggest a role for endocannabinoids in the mechanism of sustained weight loss and RYGB success, and may have implications for treatment of morbid obesity.
This report provides evidence that crocetin is a potential anticancer agent, which may be used as a chemotherapeutic drug.