Does acute triiodothyronine administration reverse depressed contractile performance following catecholamine exposure in isolated rat cardiomyocytes?
This study confirms previous reports of impaired cardiac function after high catecholamine exposure. High catecholamine exposure is associated with a desensitization of contractile proteins for calcium. Acute T3 administration increased contractility in untreated myocytes, but further depressed myocyte shortening in epinephrine-treated cells. Our results show that T3 is ineffective at restoring myocardial contractility after excessive catecholamine stimulation.
Routine nasogastric decompression is not necessary in elective operations for gastric cancer.