Are in vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration limited to the gastrointestinal tract?
While poor absorption and extensive metabolism after oral administration limited the in vivo effects of the pure AHR antagonist GNF-351 in liver, it could be used to inhibit AHR activation in intestine and colon.
The presence of wedging and decreased cervical length observed by transvaginal ultrasonography is associated with a shorter duration of induced labor and may be useful in the evaluation of induction candidates.