Do hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts?
Disruptive changes in CD44-HA interactions by HAoligos enhanced MMP-1 and MMP-3 production via activation of NF-κB and p38 MAPK signaling pathways in RSFs.
The study confirms gaps in understanding and awareness of oral cancer. Most survey participants had heard of oral cancer. However, they did not think their symptoms were indicative of cancer and they self-managed the problem. The culture of not bothering the GP/GDP unless the condition was perceived as serious is a barrier to early diagnosis and treatment. Findings support that further public awareness of oral cancer and its symptoms is required to alert the public that if their symptoms persist beyond three weeks, they need a professional opinion.