Do androgens inhibit the proliferation of a variant of the human prostate cancer cell line LNCaP?
(1) androgens inhibit the proliferation of R2 cells possibly by introducing a G0-G1 block; (2) this inhibition is incomplete because, at least in part, the R2 cell population is heterogeneous; (3) chronic androgen treatment induces reversible cell adaptation; and (4) there is no evidence that the loss of the classical stimulatory effect of androgen on cell proliferation and the gain of inhibitory effect are due to androgen receptor alteration or to a specific action of one of the four growth factors tested.
Excess weight evaluated by BMIP was associated with increased blood pressure, triglycerides, HOMAir index, and low HDL-cholesterol, a proatherosclerotic profile in children and adolescents.