Are thyroid hormone receptors down-regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock?
Patients with non-septic shock NTIS showed decreased expression of TH receptors and RXRs, which were not related to increased activation of the NFKB1 pathway. These findings could not be replicated in cultures of HSkMCs incubated in the patient's serum.
Survival from cardiac arrest is a useful measure of performance of an accident and emergency department. It is a condition that has definite outcomes, and is easily auditable. Figures can be compared between departments by comparing cases with the same aetiology or arrest rhythm thus reducing the influence of cases with a poorer outcome. This would provide an additional indicator for comparison of departments other than those currently used. A national database of outcome of cardiac arrests could be created to allow valid comparisons between departments.