Does pur-Alpha induce JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells?
Taken together, these results indicate the presence of an antagonistic interaction between these two proteins in regulating of JCV gene expression and viral replication and suggests that they play an important role during viral reactivation leading to development of PML.
Based on this single study, at a single institution, we can conclude that outcomes are acceptable in our patients, but there is very limited ability to generalize the results to different practice settings. Because of these limitations, a multicenter study with an appropriate comparison group is required to substantiate a more generalizable conclusion of efficacy of this single miniplate at inferior border.