Does blockade of endothelin-converting enzyme reduce pulmonary hypertension after cardiopulmonary bypass and circulatory arrest?
Production of endothelin-1 during CPB and circulatory arrest is a mediator of postbypass pulmonary hypertension.
Our results indicate that miR-29a ameliorates cholestatic liver fibrosis after BDL, at least partially, by modulating the profibrogenic phenotype of HSCs through inhibition of HDAC4 function.