Is sACE_5599 , a putative regulatory protein , involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea?
SACE_5599 is the second putative regulatory gene to be identified in S. erythraea which has positive influence on erythromycin yield. Like bldD, SACE_5599 is involved in morphological development of S. erythraea, suggesting a very close relationship between secondary metabolite biosynthesis and morphological differentiation in this organism. While the mode of action of SACE_5599 remains to be elucidated, the manipulation of this gene clearly shows potential for improvement of erythromycin production in S. erythraea in industrial setting. We have also demonstrated the applicability of the comparative proteomics approach for identifying new regulatory elements involved in biosynthesis of secondary metabolites in industrial conditions.
When there is a concerted effort to perform vaginal hysterectomies in lieu of abdominal ones in a residency program, the number can increase without increasing the complication rate.