Do an update expert opinion on management and research strategies in Parkinson 's disease psychosis?
Management of PD psychosis is complex. Challenges pertaining to study design, rating scales, subject recruitment and completion have limited PD psychosis treatment trials. Novel research strategies focus on nondopaminergic systems and incorporate neuroimaging, genetic associations and animal models. These strategies also have challenges but have the potential to enhance our understanding of PD psychosis and advance the development of agents that can ultimately be tested in well-designed, randomized, controlled trials.
A functional difference between the 2 main liver lobes in utero is believed to reflect differences of the vascular supply. The current findings indicate a persisting functional heterogeneity of the liver after birth not caused by perfusion differences. A relatively higher uptake of I-123 MIBG and a lower uptake of In-111 pentetreotide of the left liver lobe are normal findings.