Are pancreatic islet and stellate cells the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer?
Islet and/or PSC-derived PK1 might act through its receptors on endothelial cells to increase angiogenesis in pancreatic diseases.
This study suggest that renotrophin could be a multifactorial system that can cross the placenta. The fall in renal fetal weight following maternal nephrectomy was consequent to a lesser tissue water content. Hypoplasia or hypotrophy did not play a role in this event. However, the fall in fetal kidney water was independent of the amount of maternal renal tissue that was removed.