Does a376S in the connection subdomain of HIV-1 reverse transcriptase confer increased risk of virological failure to nevirapine therapy?
The A376S substitution in the connection subdomain of HIV-1 RT causes selective nevirapine resistance and confers an increased risk of virological failure to nevirapine-based ART.
Antecedent growth conditions determine the physiological state of bacteria including the resistance towards UV-C irradiation. In particular, the specific growth rate was shown to markedly affect UV-C resistance of E. coli. The observed pattern of UV-C resistance exhibiting a minimum at intermediate specific growth rates must be explained by two or several counteracting mechanisms. For lower specific growth rates, the regulator of the global stress response, RpoS, is at least partly involved in the physiological processes responsible for UV-C resistance.