Do volatile anesthetics inhibit the activity of calmodulin by interacting with its hydrophobic site?
Our findings demonstrate that the above VAs interact with the hydrophobic core of Ca(2+)-CaM and the interaction results in the inhibition of the conformational change and activity of CaM. This in vitro study may provide us insight into the possible mechanism of anesthetic action of VAs in vivo.
The SNP513 in human CALB2 may thus be a predictive marker for colon tumors.