Is very early detection of RET proto-oncogene mutation crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children : presence of C-cell malignant disease in asymptomatic carriers?
The consistent finding of C-cell disease in all the juvenile carriers who underwent preventive thyroidectomy emphasizes the relevance of early screening in children at risk of developing MTC. The presence of MTC in the specimen of prophylactic thyroidectomy from a 17 month old girl highlights the importance of thyroidectomy as soon as the molecular diagnosis is confirmed.
Results show guidelines for improving educational curricula and considering characteristics of nurses when planning EOL educational programs.