Is variation in the PPARalpha gene associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects?
Naturally occurring variation alters PPARalpha function, influencing plasma lipid concentrations in Type II diabetic patients but not healthy people. This demonstrates that PPARalpha is a link between diabetes and dyslipidaemia, and so could influence the risk of coronary artery disease, the greatest cause of morbidity and mortality in Type II diabetes.
Meaning-in-life is associated with all dimensions of well-being and likely plays an important role in both emotional and physical well-being.