Is early monitoring of ribavirin serum concentration useful to optimize hepatitis C virus treatment in HIV-coinfected patients?
Intracellular RBV accumulation early in treatment might improve the kinetics of HCV response in difficult to treat patients. Although this hypothesis and the potential interaction between RBV and tenofovir warrant further research, our data do not support RBV serum monitoring as a tool to optimize treatment in HCV-HIV-coinfected patients.
Transumbilical pyloromyotomy with umbilicoplasty combines ease of exposure with ease of mobilization of the pylorus. There is minimal morbidity and an excellent cosmetic result. Time to average feeding, length of stay, and complications are similar to published reports of both open and laparoscopic pyloromyotomy.