Is pravastatin , an HMG-CoA reductase inhibitor , transported by rat organic anion transporting polypeptide , oatp2?
The cloned oatp2 was identified as the transporter responsible for the active hepatocellular pravastatin uptake.
Collectively, our findings identify a key role for c-Myc in TRAIL deregulation and as a biomarker of the anticancer action of HDACi in AML. The potential improved patient stratification could pave the way towards personalized therapies.