Developing community-specific recommendations for first-line treatment of acute otitis media: is high-dose amoxicillin necessary?
In our community, although the prevalence of NSSP among isolates of S pneumoniae identified from the nasopharynx of symptomatic children is high (48%), the probability of NSSP-A infection among symptomatic children is<5%. Our data support a recommendation to treat most children who have uncomplicated AOM with standard-dose amoxicillin. Children who attend child care or have recently received an antibiotic may require treatment with high-dose amoxicillin. Other communities may benefit from a similar assessment of the prevalence of NSSP and NSSP-A.
In patients with STEMI undergoing pPCI, administration of exenatide at the time of reperfusion increases myocardial salvage.