Does acute elevation of plasma PLTP activity strongly increase pre-existing atherosclerosis?
In conclusion, acute elevation of PLTP activity destabilizes atherosclerotic lesions and aggravates pre-existing atherosclerosis.
Appropriate high glucose concentration (15.5 mM) can increase osteogenic differentiation by activating PI3K/Akt pathway in MC3T3-E1 cells, but exorbitant high glucose concentrations (25.5 and 35.5 mM) inhibited the biomineralization process. Findings indicated that PI3K/Akt pathway plays an important role in the physiological process of MC3T3-E1 cells.