Are islet insulin content and release increased in male mice with elevated endogenous GH and IGF-I , without evidence of systemic insulin resistance or alterations in β-cell mass?
Taken together, these results suggest moderate elevations in circulating GH and IGF-I can directly increase basal insulin secretion without impacting β-cell mass, independent of changes in whole body insulin sensitivity and hyperlipidemia.
When publishing cancer maps we recommend evaluating the spatial patterns observed using Tango's MEET, a global clustering test, and the spatial scan statistic, a cluster detection test.