Are markers of cellular senescence elevated in murine blastocysts cultured in vitro : molecular consequences of culture in atmospheric oxygen?
Elevated SA-β-gal, γ-H2A.X, and p21 suggest that in vitro stress can induce a senescence-like phenotype. Reduced oxygen during embryo culture minimizes these effects, providing further evidence for potential adverse effects of culturing embryos at ambient oxygen concentrations.
STEAP4 genetic variations are likely to be associated with metabolic syndrome in a female Uygur general population.