Does adenoviral gene transfer of nitric oxide synthase increase cerebral blood flow in rats?
Intracisternal injection of replication-defective adenovirus containing the eNOS gene can transiently increase cerebral blood flow.
The risk of late-recurring nodal disease increases and the chance of long-term survival decreases when wide local excision is performed without ELND. With the advent of sentinel lymphadenectomy, ELND can be selectively performed only for those nodal basins with occult tumor cells, thereby decreasing operative morbidity but allowing identification and early removal of nodal micrometastases.