Do cell-cell contacts induce STAT3 activity in colon carcinoma cells through an autocrine stimulation loop?
Changing cultivation conditions of the CRC cell line HT-29 toward detachment and aggregation, thus toward the situation in tumors, induces STAT3 activity and evokes an autocrine STAT3 activation loop.
These data demonstrate that the gonadal hormones influence the amount, distribution, and intensity of sleep but do not account for all sex differences in the sleep-wake cycle.