Does collagenase-3 ( MMP-13 ) deficiency protect C57BL/6 mice from antibody-induced arthritis?
MMP-13 deficiency acts to suppress the local inflammatory responses. Therefore, MMP-13 has a role in the pathogenesis of arthritis, suggesting MMP-13 is a potential therapeutic target.
Our results suggest that the increase in sex hormone levels could be mediated by the induction of testicular steroidogenic enzymes.