Is shear stress downregulation of platelet-derived growth factor receptor-beta and matrix metalloprotease-2 associated with inhibition of smooth muscle cell invasion and migration?
SS inhibits SMC migration and invasion via diminished PDGF-Rbeta expression. This effect of SS is associated with decreased MMP-2 secretion and MT-MMP downregulation.
Human BAT, but not WAT, expresses FGF21. The expression of FGF21 is especially high in inducible, also called beige/brite, neonatal BAT, but it is also found in the interscapular, developmentally-programmed, BAT of neonates.