Is haploinsufficiency of TNFAIP3 ( A20 ) by germline mutation involved in autoimmune lymphoproliferative syndrome?
Haploinsufficiency of TNFAIP3 (A20) by a germline heterozygous mutation leads to the ALPS phenotype.
Insulin sensitivity is impaired in some children who are SGA already at baseline and decreases with GH treatment in most of them. Children close to puberty and children who are less underweight have the highest risk to become insulin resistant.