Do circulating angiopoietin-2 levels increase with progress of chronic kidney disease?
Circulating Ang-2, a putative marker and potential mediator of accelerated atherosclerosis, is inversely related to GFR and increases with advanced CKD. The correlation between Ang-2 and ADMA points towards the hypothesis that the ADMA-driven NO deficiency might trigger Ang-2 release and account for the Ang-2 increase in CKD patients.
In severe COPD, IPPV increases dPAP and reduces pulmonary pulse pressure during inspiration.