Is contralateral metachronous tumor occurrence more frequently associated with distant metastases or postoperative intrarenal recurrence in renal cell carcinoma patients?
Metachronous occurrence of RCC in the contralateral kidney is associated with an unfavorable prognosis, suggesting that metachronous contralateral tumors might be metastasis of the original tumors. A stricter follow-up schedule is advisable for metachronous bilateral RCC patients.
TSU-68 inhibits stromal PDGF signaling activated by cancer cells and suppresses HCC growth.