Is iQGAP1 a novel CXCR2-interacting protein and essential component of the `` chemosynapse ''?
Our studies indicate that IQGAP1 is a novel essential component of the CXCR2 "chemosynapse".
In a prospective study of 46 patients with cirrhosis, we found muscle wasting, probably owing to reduced processing of ammonia, to be associated with the development of HE after TIPS placement. Sarcopenia should be considered in selecting patients for TIPS therapy. Nutritional status should be evaluated in patients with sarcopenia before TIPS placement, which might reduce the incidence of HE.