Is high dosage of dextran 70 associated with severe bleeding in patients admitted to the intensive care unit for septic shock?
In patients with septic shock, fluid treatment had changed from mainly dextran 70 in 2006 to crystalloids and albumin in 2008. The administration of high-dosage dextran 70 was associated with more patients experiencing severe bleeding.
Freeze-dried preparations of plasma-derived FVIII seem to be resistant to heat-induced structural denaturation.