Does activation of Src-dependent Smad3 signaling mediate the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury?
Our data suggest that hyperoxia-increased high-tidal-volume ventilation-induced ALI partially depends on the Src and Smad3 pathways.
The reported risk of adenocarcinoma in subjects with BE is low and not significantly decreased by a surgical antireflux procedure. Antireflux surgery in the setting of BE should not be recommended as an antineoplastic measure.