Is expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice critical for development and function of human T and B cells?
Our study demonstrates the critical role of HLA class II molecules for development of functional human T cells able to support immunoglobulin class switching and efficiently respond to vaccination.
This study suggests compromised breast cancer survival among postmenopausal women who reported drinking at least one alcoholic beverage per week, a preliminary finding that warrants further investigation.