Do pPARgamma ligands attenuate mesangial contractile dysfunction in high glucose?
MAPK suppresses PPARgamma1 at the transcriptional level, and the reduction of PPARgamma1 in cultured rat mesangial cells under the high glucose condition induces phenotypic change and loss of contractile function. PPARgamma ligands recover both reductions of PPARgamma 1 protein and contractile response.
Further, hsCRP, PP, age and DM are positively related to arterial stiffness in HD patients.