Are eSR1 and ESR2 gene polymorphisms associated with human reproduction outcomes in Brazilian women?
ER polymorphisms have an association with the assisted reproduction outcomes in Brazilian women.
CaNaPC diminishes mineralization in a cutaneous calcergy model and a model of OA in which intraarticular mineralization is a prominent feature. In the OA guinea pig model, inhibition of calcification is accompanied by diminished cartilage degeneration. CaNaPC has no therapeutic effect in the hemi-meniscectomy model. We conclude that pathologic calcification may initiate or amplify processes leading to cartilage degeneration and that CaNaPC may interrupt such a pathway.