Is ischemia-reperfusion injury more severe in older versus young rat livers?
Aging in rats is associated with greater hepatocellular injury and poor survival rate after 75 min of warm hepatic ischemia.
A significant gene-environment interaction affects airways function in laboratory animal workers. More highly endotoxin-exposed workers with CD14/-1619G alleles have significantly lower FEV(1) and FEF(25-75) percent predicted than those with CD14/-1619AA alleles. Atopic workers are particularly affected by cumulative endotoxin exposures.