Neurologic toxicity caused by zelitrex (valaciclovir) in 3 patients with renal failure. Is overdose associated with improvement of product bioavailability improvement?
Our cases focus attention on the possible neurotoxicity of valacyclovir, which is an amino acid ester prodrug of acyclovir, rapidly and almost completely hydrolysed to acyclovir prior to systemic exposure. The bioavailability of valacyclovir is 54% compared to approximately 20% for oral acyclovir and may account for unexpected overdoses, which may lead to serious neurological toxicity.
When women are unaware of the negative consequences of IPV, the physical and mental well-being of themselves and their children they do not ask for professional support. Abused women view informal support is important in the changing process. FPs should be trained to pay more attention to informal support and be alert to children's well-being.