Does herbal medicine Shakuyaku-kanzo-to reduce paclitaxel-induced painful peripheral neuropathy in mice?
A single administration of paclitaxel (10mg/kg) produced allodynia and hyperalgesia in mice, suggesting that it could be used as an animal model resembling the painful conditions observed in humans medicated with this drug. Using this model, Shakuyaku-kanzo-to was shown to relieve paclitaxel-induced painful peripheral neuropathy.
Despite an apparent morbidity with a loss of benefit, informed consent of the patients were rarely obtained.