Are cytochrome P450 2B6 ( CYP2B6 ) and constitutive androstane receptor ( CAR ) polymorphisms associated with early discontinuation of efavirenz-containing regimens?
These data indicate that genetic variability in CYP2B6 and CAR contributes to early treatment discontinuation for efavirenz-based antiretroviral regimens. Further studies are now required to define the clinical utility of these associations.
These data reveal novel functional roles for AMPK in regulating mTOR signaling, cell cycle, survival and metabolic responses to IR.