Do high CD34 cell doses worsen regimen-related toxicity or early mortality after autologous blood stem cell transplantation for breast cancer?
We conclude that CD34(+) cell doses >20 x 10(6)/kg do not affect transplant outcome in a negative or positive fashion.
This study demonstrates that beta(2)-receptor blockade reduces macrophage cytokine production and improves survival showing the critical importance of catecholamines to the immunologic response in surgery.