Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder?
On average, the risk of dementia seems to increase with the number of episodes in depressive and bipolar affective disorders.
Stable TNF trimers, created by internal covalent cross-linking, show improved signaling. The high structural homology within the TNF superfamily provides an opportunity to extend internal cross-linking to other TNF superfamily proteins to produce active trimers with improved stability and receptor signaling, and with potential applications for cancer, autoimmunity, infections, and transplantation.