Does aPR-246 exhibit anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells?
We conclude that APR-246 is effective in AML cells irrespectively of TP53 mutational status and that it has promising properties for combination studies in AML.
This study demonstrates the importance of restoration of the anatomic insertion point of the MPFL when performing MPFL reconstruction and proposes that this procedure should not be performed in isolation in patients with high-grade trochlear dysplasia.