Is the erythropoietin receptor required for the development , function , and aging of rods and cells in the retinal periphery?
Our data suggest that expression of EPOR in rod photoreceptors, Müller cells, and amacrine, horizontal, and ganglion cells of the peripheral retina is not required for the maturation, function, and survival of these cells in aging tissue. Based on the expression of the EPOR-signaling target genes, we postulate that expression of soluble EPOR in the retina may modulate endogenous EPO-EPOR signaling.
Focal radiotherapy with safety margins of<4 cm appears to be associated with a very high rate of out-field recurrence, but the use of a radiation field with generous safety margins (>or = 4 cm) appears to be worth further investigation.