Is the combination of gemcitabine and vinorelbine an active regimen as second-line therapy in patients with metastatic breast cancer pretreated with taxanes and/or anthracyclines : a phase I-II study?
The optimal GemVin schedule is an effective and well tolerated second-line therapy in patients with metastatic breast cancer pre-treated with anthracycline-based schedules or with combinations of anthracyclines and taxanes.
Tranilast significantly decreases tissue TGF-beta, resulting in a reduction in tubular apoptosis and an increase in tubular proliferation. This finding suggests that tranilast is a promising agent for preventing renal tubular damage in unilateral ureteral obstruction.