Does cortical hyperexcitability precede lower motor neuron dysfunction in ALS?
The findings in the present study suggest that cortical hyperexcitability occurs upstream to a seemingly intact lower motor neuronal system.
These data contrast with the established literature which suggests that CHPG is a selective mGluR5 agonist. Instead, CHPG appears to act equally well as an agonist at mGluR1. While some weak biased agonism was observed with CHPG acting on mGluR1, but not mGluR5, favoring Gi/o signaling over Gq/11, this effect does not appear sufficient to fully explain the discrepancies in the literature.