Is transforming growth factor alpha ( TGF-alpha ) expression in biopsies of colorectal carcinoma a significant prognostic indicator?
It is concluded, therefore, that low or absent expression of TGF-alpha in pre-operative biopsies of patients with CRCA, as detected by immunohistochemistry, is a significant predictor of an unfavorable outcome.
(1) In old age, there is a polyclonal TPO autoantibody response but the majority of the autoantibodies are directed to the TPO region mapped by or close to mAb9 (domain A); (2) the autoantibody response does not differ in elderly subjects with or without the clinical manifestations of autoimmune thyroid disease and does not depend on the iodine supply of the elderly subjects.