Do people with diabetes who need to talk want to talk?
Those who want to talk are those who need to talk. Future service development issues should acknowledge the needs and expressed wishes of service users.
Together, our data implicate Top1mt for mitochondrial integrity and energy metabolism. The compensation mechanism described here contributes to the survival of Top1mt-/- cells and mice despite alterations of mitochondrial functions and metabolism. Therefore, this study supports a novel model for cellular adaptation to mitochondrial damage.