Does the novel gene MIA2 act as a tumour suppressor in hepatocellular carcinoma?
This study presents MIA2 as an inhibitor of HCC growth and invasion both in vitro and in vivo, and consequently, as a tumour suppressor of HCC. Further, our findings indicate a novel mechanism, how loss of HNF-1 expression in HCC affects tumorigenicity via down-regulation of MIA2.
Bilateral benefit for delayed sequentially implanted adults is less than previously reported for simultaneous and sequentially implanted adults. Delayed sequential implantation benefit seems to relate to the availability of the ear with the most favourable SNR.