Does pH and drug ionization affect ocular pressure lowering of topical carbonic anhydrase inhibitors?
Increasing the ionization of three ampholyte topical carbonic anhydrase inhibitors increases their ocular hypotensive activity. These data taken with ocular disposition data suggest that ionized compounds of this type are more readily sequestered in the cornea, which serves as a drug depot for prolonged drug delivery and activity.
In the present study, the use of BASF Sunscreen Simulator and in vitroUVA tests showed good correlations with in vivo results and could be considered as valuable resources in the development of sunscreens.