Differential expression of urocortin in human testicular germ cells in course of spermatogenesis: role for urocortin in male fertility?
The expression of urocortin in normal adult and fetal testicular germ cells in the cell division arrest phases suggests a probable role for this peptide in the pathophysiology of germ cell differentiation and division. In human germ cells, the separate location of urocortin and its receptors indicates a receptor-independent action of urocortin in the course of spermatogenesis.
Endothelium, when exposed to high density CACs, releases PTX3 which markedly impairs the vascular regenerative response in an autocrine manner. Therefore, CAC density and accompanying release of angiocrine PTX3 are critical considerations when using these cells as a cell therapy for ischemic disease.