Does [ Heme oxygenase-1 inhibit thrombosis under oxidative stress ]?
Under conditions that stimulate HO-1 production, platelet-dependent thrombus formation is inhibited by HO-1 through the pathway of cGMP expression. It suggests that enhanced platelet HO-1 expression in response to physiological stress may represent an adaptive response mechanism to down-regulate platelet activation under pro-thrombotic conditions.
Our results suggest a role of PPARG gene in the development of SSc.