Is testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes?
These data suggest a catalytic effect of PPAR ligands on cellular testosterone activation by 5alpha-reduction and the importance of the latter for the regulation of sebaceous lipids.
Although the number of study subjects was little, abnormal AXR sweating in patients with AD was observed. Correlative analysis suggests possible involvement of continuous anxiety and the immune system in such abnormal sudomotor function.