Does chemokine CXCL8 promote HIV-1 replication in human monocyte-derived macrophages and primary microglia via nuclear factor-κB pathway?
Our results show that CXCL8 mediates productive infection of HIV-1 in MDM and microglia via receptors CXCR1 and CXCR2. These results demonstrate that CXCL8 exerts its downstream effects by increasing translocation of nuclear factor-κB into the nucleus, thereby promoting HIV-1 LTR activity.
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