Do women who experience detrusor overactive at lower bladder volumes report greater bother?
Women who experience DOI at lower volumes during urodynamics report greater bother and QOL impact from incontinence than women who leak at higher volumes.
The present study suggests that AGE-RAGE-mediated ROS generation activates TGF-beta-Smad signaling and subsequently induces mesangial cell hypertrophy and fibronectin synthesis by autocrine production of Ang II. This pathway may provide an important link between metabolic and haemodynamic factors in promoting the development and progression of diabetic nephropathy.