Do cysteinyl leukotrienes regulate TGF-β ( 1 ) and collagen production by bronchial fibroblasts obtained from asthmatic subjects?
Fibroblasts from asthmatic subjects express high level of CysLT1R. LTD(4) regulates procollagen I(α(1)) transcription in fibroblasts derived from asthmatic patients by modulating TGF-β(1) expression. This suggests that CysLTs may play a role in regulating collagen deposition in asthma.
The antipsychotic effect of ECT is related to normalization of subgenual ACC theta hypoactivity.