Is lactic acidosis after cardiac surgery associated with polymorphisms in tumor necrosis factor and interleukin 10 genes?
Genetic factors have a role in the development of lactic acidosis after cardiac surgery.
The present study demonstrates the existence of previously undetected systematic conformational and dynamic differences between the heavy chains of the 2 HLA-B27 subtypes. Since effector cell recognition of cells expressing HLA antigens is dependent on the dynamic properties of the interacting cell surface molecules, this HLA-B27 subtype-specific heavy chain flexibility could have a role in the distinct association of HLA-B27 subtypes with spondylarthritides.