Do oral bisphosphonates increase the risk of severe upper gastrointestinal complications : a nested case-control study?
Further evidence that BPs dispensed for secondary prevention of osteoporotic fractures are not associated with increased risk of severe gastrointestinal complications is supplied from this study. Further research is required to clarify the role BPs and other drugs of co-medication in inducing UGIC.
This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation.