Do cNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling?
In sum, our data demonstrate that axon regeneration inhibitors such as Nogo trigger gene expression programs including an SRF-dependent IEG response via MAP kinases and Rho-GTPases.
The NO-induced decrease of ACh release is probably due to an NO-induced increase of GABAergic system inhibition.