Does the orphan nuclear receptor COUP-TFII coordinate hypoxia-independent proangiogenic responses in hepatic stellate cells?
This study elucidates a novel transcriptional pathway in HSC that is involved in the acquisition of the proangiogenic phenotype and regulates the paracrine signals between HSC and sinusoidal endothelial cells during hepatic wound healing.
Two surgical observations that are reliable to confirm a complete release of the TCL were described. The first, called the "fat pad" sign, is useful to determine whether or not the distal end of the TCL has been adequately released, whereas the "little finger pulp" sign indicates whether or not the proximal end of the TCL has been fully divided.