Does hydroxyurea accelerate the loss of epidermal growth factor receptor genes amplified as double-minute chromosomes in human glioblastoma multiforme?
These studies suggest the potential use of low-dose hydroxyurea in the treatment of GBMs.
OPN upregulation during liver injury is a conserved repair response, and influences liver progenitor cell function. OPN-neutralisation abrogates the liver progenitor cell response and fibrogenesis in mouse models of liver fibrosis.