Does acidosis plus melphalan induce nitric oxide-mediated tumor regression in an isolated limb perfusion human melanoma xenograft model?
Acidosis enhances the antitumor effect of melphalan. NO induction appears to play a role in tumor regression.
The 5α-reductase is the gatekeeper of the backdoor pathway, whereas the 17,20-lyase activity of CYP17A1 is the regulator of the flux through the androgen pathways.