Does sucralfate prevent apoptosis occurring in the ischemia/reperfusion-induced intestinal injury?
The present study shows that 1) the experimental model of I/R-induced intestinal injury induces enterocyte apoptosis; 2) sucralfate decreases enterocyte apoptosis in the experimental model of I/R-induced intestinal injury which may play a key role in the pathophysiological events leading to failure of the intrinsic gut barrier defense mechanisms.
Abdominal obesity increases the risk of developing a parastomal hernia, therefore, it might be advisable to place a prophylactic mesh during colostomy formation when the patient's waist exceeds 100 cm.