Do sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington 's disease?
HD is primarily accompanied by night-time sleep disturbances and a delayed sleep phase, which are associated with depression and lower cognitive as well as functional performance.
The amount of metastatic melanoma in an SLN is an independent predictor of survival. Patients with SLN metastatic deposits>2 mm in diameter have significantly decreased survival.