Do the efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn?
A single intraperitoneal dose of 5-FU had a preventive effect on stricture formation after caustic esophageal burn. This observation suggests that 5-FU may prevent this undesirable complication in the clinical setting. Clinical studies are now required to verify this form of treatment. Local intraesophageal application of 5-FU immediately after the burn injury was not effective. Further investigations are required to determine the appropriate timing of application of 5-FU at the local site of injury.
In this prospective population-based study, exposure to tricyclic antidepressants was associated with higher risk of first CHD events.