Does c-reactive protein induce interleukin-6 and thrombospondin-1 protein and mRNA expression through activation of nuclear factor-ĸB in HK-2 cells?
CRP induces IL-6 and TSP-1 protein release and mRNA expression from HK-2 cells via activation of the p38MAPK and NF-κB signaling pathways and TGF-β(1) was highly expressed in HK-2 cells, suggesting that CRP plays an important role in the propagation and prolongation of inflammation in renal fibrosis.
The majority of the applicants for meals-on-wheels were at risk for poor nutritional status. Thus, many independent-living older adults may need additional nutrition assessment and intervention to remain independent and in good nutritional status.