Does yeast histone H3 lysine 4 demethylase Jhd2 regulate mitotic rDNA condensation?
Our results show that yeast Jhd2, which demethylates histone H3 Lys4 near the rDNA locus, regulates rDNA repeat stability and rDNA silencing in a Sir2-independent manner by maintaining Csm1/Lrs4 and condensin association with rDNA regions during mitosis. These data suggest that Jhd2-mediated alleviation of excessive Csm1/Lrs4 or condensin at the NTS1 region of rDNA is required for the integrity of rDNA repeats and proper rDNA silencing during mitosis.
Although falling and OH were both highly prevalent in nursing home residents, no relationship between OH and falling was found.