Does the synthetic triterpenoid TP-222 inhibit RANKL stimulation of osteoclastogenesis and matrix metalloproteinase-9 expression?
Our data demonstrate that TP-222 inhibits osteoclast formation and MMP-9 expression in vitro and in vivo, and suggest that triterpenoids may be useful compounds for modulating bone resorption diseases.
The present study suggests that PN does not stimulate tumor proliferation in malnourished patients affected by gastric cancer.