Does deletion of p75NTR impair regeneration of peripheral nerves in mice?
Our data suggest that p75NTR plays an important role in the regeneration of injured peripheral nerves.
CPB reduces ERK1/2 and p38 activity in peripheral tissue, potentially by MKP-1. Contractile responses of peripheral arterioles to phenylephrine and vasopressin are dependent on ERK1/2 and p38 and are decreased after CPB. These results suggest that alterations in MAPK pathways in part regulate peripheral microvascular dysfunction after CPB in humans.