Is the maternal transcriptome of the crustacean Parhyale hawaiensis inherited asymmetrically to invariant cell lineages of the ectoderm and mesoderm?
In contrast to Drosophila, the four primary germ layer cell lineages in Parhyale are specified during the maternal control phase of the embryo. A key step in this process is the asymmetric distribution of a large number of maternal RNAs to the germ layer progenitor cells.
High serum amphiregulin levels were associated with early disease progression in these patients, possibly due to AKT and ERK signaling activation by amphiregulin.