Does interferon-gamma induce caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter?
Interferon-gamma induces procaspase-8 expression in neuroblastoma cells, and this induction is not dependent on demethylation of the caspase-8 promoter. Therapies aimed at inducing caspase-8 expression by adjunctive treatment, such as interferon-gamma, may increase the effectiveness of current chemotherapeutic regimens.
From the results obtained in the present study it would seem that the experience of a false positive breast screen does not deter women from reattending in the future. However, many women living in inner city areas who attend for an initial breast screen are failing to attend for subsequent routine mammograms. This may have a deleterious effect for these women in terms of the benefits of attendance for regular screening.