Does bortezomib-mediated downregulation of S-phase kinase protein-2 ( SKP2 ) cause apoptotic cell death in chronic myelogenous leukemia cells?
Altogether, these findings suggest that bortezomib suppresses the cell proliferation via induction of apoptosis in CML cells by downregulation of SKP2 with concomitant accumulation of p27Kip1, suggesting that proteasomal pathway may form novel therapeutic targets for better management of CML.
These data further implicate MMP17 in the control of articular cartilage extracellular matrix aggrecan integrity in an inflammatory environment.