Are disposition and sterol-lowering effect of ezetimibe influenced by single-dose coadministration of rifampin , an inhibitor of multidrug transport proteins?
Coadministration of rifampin increases the maximum serum concentrations of ezetimibe but reduces its enterosystemic recycling, most likely by inhibition of the secretion of ezetimibe and its glucuronide via P-gp and MRP2.
The findings support the view that both shared and differential self-evaluative processes are involved in depression and social anxiety.