Is hypertension a major risk factor in aneurysmal subarachnoid hemorrhage?
Patients with hypertension had a nearly seven-fold higher risk of aneurysmal subarchnoid hemorrhage. This seems to substantiate the hypothesis that aneurysm is an acquired and hemodynamically induced chronic disease.
Direct aconitase inhibition interferes with erythropoiesis in vivo and in vitro, confirming a lineage-selective regulatory role involving its enzymatic activity. This inhibition spares metabolic function but impedes EPO-induced ERK signaling and disturbs a newly identified ERK-aconitase physical interaction. We propose a model in which aconitase functions as a licensing factor in ERK-dependent proliferation and differentiation, thereby providing a regulatory input for iron in EPO-dependent erythropoiesis. Directly targeting aconitase may provide an alternative to phlebotomy in the treatment of polycythemia vera.