Are symptoms in patients with ulcerative colitis in remission associated with visceral hypersensitivity and mast cell activity?
Rectal hypersensitivity is associated with mucosal presence and activation of mast cells and with IBS-like symptoms in patients with UCR.
A significant proportion of UCs revealed low positivity percentages for MLH1 expression, probably reflecting MLH1 gene dysfunction in the respective cases. Preserved MLH1 expression was associated with highly proliferating cells, which are more likely to need DNA repair systems. A reduced expression of MLH1 may exert an adverse influence on the apoptotic potential of cancer cells.