Does the CFTR Potentiator Ivacaftor augment Mucociliary Clearance Abrogating CFTR Inhibition by Cigarette Smoke?
Cigarette smoking transmits acute reductions in CFTR activity, adversely affecting the airway surface. These effects are reversible by a CFTR potentiator in vitro, representing a potential therapeutic strategy in COPD patients with chronic bronchitis.
US reduces the number of attempts, LA volume, and postoperative pain when compared with NS for ISB.