Is IP-10 an accurate marker for detecting M. tuberculosis-specific response in HIV-infected persons?
HIV infection does not impair RD1-specific response detected by IP-10, while it significantly decreases IFN-γ-mediated responses. At the moment it is unclear whether higher detection is related to higher sensitivity or lower specificity of the assay. Further studies in high and low TB endemic countries are needed to elucidate this.
The extent to which these findings generalize to other populations of people with stroke, such as those with stroke <7 days prior, remains uncertain.