Is deletion of alloreactive T cells by veto cytotoxic T lymphocytes mediated through extracellular signal-regulated kinase phosphorylation?
These results suggest that the interaction between CD8 on veto CTL and the MHC class I alpha3 domain on the effector cell, leads to phosphorylation of MEK/ERK in the latter cell, associated with a significant reduction of XIAP levels which, in turn, enables potent triggering of Fas-FasL mediated apoptosis on cognate binding of the veto CTLs.
Angina symptoms in ages as low as 40-49 years were associated with elevated long-term CHD mortality in Norwegian women and men. This indicates that the three-item version of the Rose Angina Questionnaire, although a screening tool rather than a diagnostic test, adds information on undiagnosed CHD in both sexes.