Does aSIC3 contribute to the blunted muscle metaboreflex in heart failure?
Compared with those in controls, cardiovascular responses to lactic acid administered into the hind limb muscles are blunted in HF rats owing to attenuated ASIC3. This suggests that ASIC3 plays a role in engagement in the attenuated metaboreceptor component of the exercise pressor reflex in HF.
Moderately increased albuminuria is an independent predictor of cardiovascular events in the general Japanese population under 75 years of age.