Is cellular proliferation and infiltration following interstitial irradiation of normal dog brain altered by an inhibitor of polyamine synthesis?
There is substantial cell proliferation and infiltration in response to interstitial irradiation of normal brain, and these responses are significantly altered by DFMO treatment. Although the precise mechanisms by which DFMO exerts its effects in this model are not known, the results from this study suggest that modification of radiation injury may be possible by manipulating the response of normal cells to injury.
Our results indicate that Kupffer cell blockage with GdCl3 attenuates the myocardial injury induced by aortic IR. We think that the novel findings of the present study may be a basis for further studies investigating the role of GdCl3 pretreatment in reducing myocardial morbidity and mortality caused by aortic IR during aortic surgery.