Are genetic Polymorphisms in the HTR2C and Peroxisome Proliferator-Activated Receptors Associated with Metabolic Syndrome in Patients with Schizophrenia Taking Clozapine?
We did not find significant associations between four polymorphisms (HTR2C-759C/T, HTR2C-697G/C, PPARα V227A, and PPARγ 161C/T) and MetS in patients with schizophrenia taking clozapine.
We have investigated the majority of the known MRX families linked to the TM4SF10 gene region. In the absence of mutations detected, our study indicates that alterations of TM4SF10 are not a frequent cause of XLMR.