Is efficacy of zoledronic acid in treatment of teoarthritis dependent on the disease progression stage in rat medial meniscal tear model?
The stage of OA progression influences the efficacy of ZOL in treating joint degeneration and pain. To obtain the maximum efficacy, bisphosphonate treatment should be initiated in rat with early stages of OA pathogenesis.
MiR-144 is functioning as a tumor suppressor in ALL, very likely through the inverse regulation of its target gene FMN2.