Does etodolac block the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation?
Etodolac showed a selective TRPA1 agonist action, providing evidence that etodolac desensitizes nociceptors by the selective activation of TRPA1. Etodolac may be clinically useful in the treatment of neuropathic pain.
With this technique transdiaphragmatic pressure can be measured using a single catheter which can easily be cleaned and reused. The values for sniff PDI are similar to those recorded previously with air filled balloons, suggesting that the method of recording pressure does not significantly affect the values obtained.