Is phosphoglycerate dehydrogenase a novel predictor for poor prognosis in gastric cancer?
PHGDH is important in predicting patient outcomes and is a potential target for the development of therapeutic approaches to GC.
This study is the first to show that a bioactive compound derived from cruciferous vegetables, I3C, abolishes the E2-mediated stimulation of cell activities including, proliferation and differentiation, in rat osteoblasts and increases the 2-hydroxylation of E1, resulting in the formation of inactive and anti-estrogenic metabolites. These results suggest that in neonatal rat osteoblasts, the anti-estrogenic effect of I3C is mediated by 2-OHE2 through ER-α.