Does piper sarmentosum prevent glucocorticoid-induced osteoporotic bone resorption by increasing 11β-hydroxysteroid dehydrogenase type 1 activity?
This suggests that 11βHSD1 acts as the local regulator of glucocorticoid and its activity in bone was not correlated to systemic corticosterone level.
sVCAM and sTNF RII levels in the serum of SPMS patients are increased during IFNbeta-1b therapy and may at least in part explain some of the treatment effects, like reduced immune cell transmigration.