Does pioglitazone modulate the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma?
Pioglitazone inhibits VSMCs proliferation and promotes apoptosis of VSMCs through a PPARγ signaling pathway. Up-regulation of caspase 3 and down-regulation of cyclins mediates pioglitazone's anti-proliferative and pro-apoptotic effects. Our results imply that pioglitazone prevents the VSMCs proliferation via modulation of caspase and cyclin signaling pathways in a PPARγ-dependent manner.
Unicompartmental knee arthroplasty with the Marmor/Mod 2 prosthesis has provided satisfactory long-term durability in this cohort of elderly patients, in comparison with similar published studies featuring other prostheses.