Does 5HT ( 3 ) antagonism abolish the emotion potentiated startle effect in humans?
These results suggest an involvement of 5HT3 receptors in certain aspects of fear processing in humans. These effects are consistent with anxiolytic actions of 5HT3 antagonism in animal models and suggest that the 5HT3 receptor may play a role in the effects of serotonergic manipulations on fear and anxiety.
Only male rats were investigated, and the THC/CBD coadministration experiment was carried out in a subset of individuals.