Is treatment persistence with monthly zoledronic acid associated with lower risk and frequency of skeletal complications in patients with breast cancer and bone metastasis?
ZA treatment was associated with lower risk and frequency of skeletal complications and longer follow-up time. Greater persistence with ZA treatment was associated with better outcomes.
FoxO1 plays a crucial role in the transdifferentiation and proliferation of HSCs in liver fibrosis. Hyperinsulinemia inactivates FoxO1 in HSCs, resulting in HSC activation and may result in the fibrosis in nonalcoholic fatty liver disease.