Does small interfering RNA-mediated downregulation of beta-catenin inhibit invasion and migration of colon cancer cells in vitro?
siRNA-mediated downregulation of beta-catenin could be valuable for defining gene expression and functional programs downstream of oncogenic beta-catenin signals, which, in turn, may be helpful to isolate novel diagnostic markers, and for designing tumor-specific intervention at downstream targets of oncogenic beta-catenin.
In conclusion, our investigation suggests that: (1) the general activity of NF-kappaB is attenuated in IPC kidneys, and (2) the remaining activation of NF-kappaB is dominated with p50/p50 homodimer. Both of these effects might subsequently downregulate IL-18 expression, as well as provide renal protective effects of IPC. Though we focused on the phenomenological observations in this study, the detailed mechanism is still to be determined.