Do early initiation of dialysis and late implantation of catheters adversely affect outcomes of patients on chronic peritoneal dialysis?
Our data do not support earlier initiation of PD, but underscore the importance of planned implantation of catheters before commencement of chronic PD.
These data support a model in which the 3'-oxyanion leaving group of the transesterification reaction is stabilized by a hydrogen-bonding triad consisting of the 2'-OH groups of U(-1) and A207 and the exocyclic amine of G22. Because all three nucleotides occur within highly conserved non-canonical base pairings, this stabilization mechanism is likely to occur throughout group I introns. Although this mechanism utilizes functional groups distinctive of RNA enzymes, it is analogous to the transition states of some protein enzymes that perform similar phosphoryl-transfer reactions.