Is high serum YKL-40 concentration associated with severe bone disease in newly diagnosed multiple myeloma patients?
Newly diagnosed MM patients with elevated serum concentrations of YKL-40 have more severe bone destruction including increased bone resorptive activity and shorter time to progression of bone disease. At this point, a potential role for YKL-40 in myeloma-related bone disease must be considered.
Our proposed fiber-tracking method was shown to be a clinically feasible technique that correlates well with clinical symptoms.