Is nephrotoxic nephritis mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells?
Despite previous evidence that mesangial cells express Fcgamma receptors in vitro, they have no role in an FcRgamma-dependent model of glomerulonephritis in vivo.
These results demonstrate that administration of the LXR agonist GW3965 increases the rate of RCT from macrophages to feces in vivo.