Is a high-performance liquid chromatography method for the serotonin release assay equivalent to the radioactive method?
The HPLC-SRA has robust performance characteristics, equivalent to the historic radioactive method, but avoids the complexities of working with radioactivity.
These novel secretory polypeptides may contribute to NB growth. The proteins may reveal additional tumor markers and permit putative use in the diagnosis and treatment of NB. Detection of these proteins in serum of children with NB vs controls (using 2-dimensional polyacrylamide gel electrophoresis and mass spectrometry techniques) is currently in progress.