Does association of RhoGDIalpha with Rac1 GTPase mediate free radical production during myocardial hypertrophy?
Myocardial hypertrophy is characterized by activation of Rac1 and NADPH oxidase. The association of the regulatory protein RhoGDIalpha with Rac1 represents a necessary step in the Rac1-dependent release of ROS. Rac1-RhoGDIalpha binding may represent a target for anti-hypertrophic pharmacologic interventions, potentially by statin treatment.
Results from this study demonstrate that VEGF potentially promotes bone repair, warranting further research in this direction.