Does levosimendan improve contractility in vivo and in vitro in a rodent model of post-myocardial infarction heart failure?
In HF animals, LEV improved the contractility by increasing the Ca(2+) sensitivity. Furthermore loading conditions were changed, and LEV could consequently change organ perfusion. An observed increase in diastolic Ca(2+) following LEV treatment and clinical implications of this should be further addressed.
We found that thyroid hormone regulates the expression of SHP mRNA through interference with the transcription factor, LRH-1.