Do large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles?
In summary, our data elucidate a new explanation underlying the p phenotype, implicating the deleted regions of A4GALT as crucial for P1 and P(k) synthesis, possibly due to loss of binding sites for erythroid transcription factors. Furthermore, analysis of these regions will improve genetic blood group prediction.
In this large representative sample of patients undergoing ACLR in the United States, 48.2% of the cohort was nonwhite, and racial variations in sex, age, sport at injury, and intraoperative findings at ACLR were identified. Understanding the differences in ACL injury presentation and concomitant injuries by race can be useful in helping tailor the development of an ACL injury prevention program, during the informed consent process, and in the arthroscopic portion of the procedure according to patient race-specific characteristics.