Is gRK2 blockade with βARKct essential for cardiac β2-adrenergic receptor signaling towards increased contractility?
GRK2 inhibition in vivo with βARKct is absolutely essential for cardiac β2AR pro-contractile signaling and function. In addition, β2AR anti-apoptotic signaling in post-MI HF is augmented by βARKct, although this effect is short-lived.
Frequenting rheumatology clinics and referrals to other specialists significantly varies between centres, after adjustment by patient characteristics.