Do dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death?
Dual function microtubule-associated (MAP) and mitochondria-associated (MtAP) proteins generated by prolonged mitotic arrest trigger mitochondrial-induced mitotic cell death. This is a potential mechanism to prevent minimal survivable aneuploidy resulting from an aberrant cell division and cancers in general at their earliest common origin.
In patients with RI, PCI using PES provides poorer clinical outcomes than SES in terms of MACE and all-cause death.