Are mutations in chaperonin-like BBS genes a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population?
While overlap between the MKKS and BBS phenotypes has previously been reported for cases with BBS6 mutations, we also observed MKKS phenotypes involving BBS10 and BBS12 and Alström-like phenotypes associated with mutations in BBS1, BBS2, BBS6, BBS7, BBS9, BBS10 and BBS12 for the first time.
A dimeric oleosin approach can be used to express KGF2 with the non-symmetrical O-O::KGF2 construct showing the highest expression and bioactivity.