Does activation of Adenosine Triphosphate-regulated Potassium Channels during Reperfusion restore Isoflurane Postconditioning-induced Cardiac Protection in Acutely Hyperglycemic Rabbits?
KATP channel activation restored anesthetic postconditioning-induced myocardial protection under acute hyperglycemia. This effect occurred without increasing Akt or eNOS phosphorylation, suggesting that KATP channels are located downstream to Akt and eNOS in the pathway of isoflurane-induced myocardial postconditioning.
We propose that palmitoyl-protein desaturation defines a new mechanism of proteolipid modification, and that deficiency of this process leads to the signs and symptoms of Batten's disease.