Does airway pressure release ventilation prevent ventilator-induced lung injury in normal lungs?
Continuous mandatory ventilation in normal rats for 6 hours with Vt and PEEP settings similar to those of surgery patients caused ALI. Preemptive application of APRV blocked early drivers of lung injury, preventing ARDS. Our data suggest that APRV applied early could reduce the incidence of ARDS in patients at risk.
The hypothesis that altered blood flow is related to the development of GI symptoms in endurance athletes is not supported by the results of this study. Other mechanisms for GI symptoms associated with endurance exercise should be investigated.