Are vitamin D receptor polymorphisms associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations?
The genotype 'BB' as well as 'B' allele at BsmI polymorphism of the VDR gene contribute to the risk of PBC development.
Sustained and quite intensive health promotion activity had only a limited effect in men identified as being at high risk of CHD. In particular, there was little change in body mass or serum cholesterol. Although improved blood pressure control and a moderate reduction in the prevalence of smoking can be achieved, further research is needed to determine the most effective methods of risk factor reduction in order to realize the full potential of the 'high-risk' approach to the prevention of CHD.