Does toll-like receptor 4 mediate oxidized LDL-induced macrophage differentiation to foam cells?
TLR4 is necessary for oxLDL-induced macrophage differentiation to foam cells. Macrophage foam cell clustering may indicate an underlying intercellular signaling mechanism that facilitates foam cell formation. We conclude that TLR4 contributes to the pathogenesis of atherosclerosis by promoting foam cell formation.
A stroke patient's use of mechanical ventilation on the first day of hospitalization is a valid proxy indicator of level of consciousness.