Are functional dissection of DNA supercoiling factor : EF-hand domains and C-terminal HDEF motif essential for its activity?
Two regions of SCF play critical roles in the supercoiling activity. The C-terminal HDEF is essential for the factor binding to topoisomerase II. The EF-hand domains II and III are functional for the Ca2+ binding that induces a mobility change in the factor upon gel electrophoresis.
Postoperative AF affects early and late mortality after isolated coronary artery bypass graft surgery. Patients affected by AF are at higher risk of fatal embolic events. Careful postoperative surveillance with a specific antiarrhythmic and antithrombotic prophylaxis, aimed at reducing AF and its complications, is recommended.