Does ethanol stimulate endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway?
These data demonstrate that ethanol, at levels consistent with moderate consumption, enhances endothelial angiogenic activity in vitro by stimulating a novel Notch/CBF-1/RBP-JK-Ang1/Tie2-dependent pathway. These actions of ethanol may be relevant to the cardiovascular effects of alcohol consumption purported by epidemiological studies.
Spinal anesthesia in diabetic patients is associated with a reduction in VO2, the extent of which appears to be, at least in part, a function of the level of spinal sensory block.