Is apoptotic cell death a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage : a study of proliferation , programmed cell death ( apoptosis ) , and viability of chondrocytes in normal and osteoarthritic human knee cartilage?
Our results confirm the findings of previous studies showing that cell proliferation occurs in OA cartilage. They also show that, contrary to previous suggestions, apoptotic cell death is not a widespread phenomenon in aging or OA cartilage.
LDL electrostatic interactions with decorin and biglycan in the valve leaflets and vascular wall is a major source of LDL retention. The complementary electrostatic sites on LDL or these proteoglycans may provide a novel therapeutic target for preventing one of the earliest events in these cardiovascular diseases.