Does redox cycling by motexafin gadolinium enhance cellular response to ionizing radiation by forming reactive oxygen species?
Gd-Tex sensitizes cells to ionizing radiation by increasing oxidative stress as a consequence of futile redox cycling. Optimization of the concentration of ascorbate (or other reducing species) may be required when evaluating Gd-Tex activity in vitro.
The prognostic significance of VCP expression in NSCLC was demonstrated.