Is mUC1 overexpression the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor ( IPMT )?
MUC1 overexpression is considered to be the most sensitive and specific marker of invasive carcinoma, followed by DPC4 and p53 with less sensitivity.
The large blocks of subtelomeric heterochromatin have arisen from the combined activity of TEs and the expansion of the tandem repeats. The expansion was likely based on a highly complex network of recombination mechanisms.