Does angiotensin IV have mixed effects on left ventricle systolic function and speeds relaxation?
AT4 receptor agonism has mixed effects on LV systolic function, depressing pressure-generation and ejection capabilities, but enhancing the sensitivity of pressure development to volume change. It also speeds relaxation. The effect of Ang IV on systolic function is generally opposite to the effect of Ang II, whereas the Ang IV influence on relaxation is similar to the effect of Ang II.
Airway intervention was not found to be a risk factor for poor oncological or functional outcome in this patient group.