Does ascorbic acid induce osteoblast differentiation of human suspension mononuclear cells?
Ascorbic acid alone was sufficient to induce osteoblast differentiation from suspension MNCs; 30-90 μg/mL of ascorbic acid was found to be the optimal concentration. Ascorbic acid can be used as a nutritional supplement for cellular therapy of bone-related disease.
We conclude that urea hydrolysis is an acute nitrogen-sparing mechanism that can counterbalance a postprandial higher urea production, and the efficiency of this recycling is higher when the usual protein intake is lower.