Is induction of pulmonary connective tissue growth factor in heart failure associated with pulmonary parenchymal and vascular remodeling?
Pulmonary CTGF was substantially increased in parallel with pulmonary remodeling in rats with HF. Our data indicate that alveolar macrophages are a major source of increased pulmonary CTGF in HF and that CTGF may be a player in the profibrotic mechanisms associated with HF.
AHRR is a novel and readily available prognosticator in patients with CHF, which may reflect autonomic tone and exercise capacity.