Does brief, clinically based, intensive multimodal behavior therapy enhance the effects of methylphenidate in children with ADHD?
No evidence was found for the additive effect of multimodal behavior therapy next to optimally titrated methylphenidate.
The mitochondrial IDHs are redundant for insulin secretion. When both enzymes are severely knocked down, their low activities (possibly assisted by transport of IDH products and other metabolic intermediates from the cytosol into mitochondria) are sufficient for cell growth, but inadequate for insulin secretion when the requirement for intermediates is certainly more rapid. The results also indicate that IDH2 can support the citric acid cycle.