Is the magnitude of the central response to esophageal electrical stimulation intensity dependent?
The clear dose-response relationship in the brain response with increasing stimulus intensities probably reflects increased recruitment of afferent fibers. Early peaks originate from deep central brain structures, whereas later peaks are localized exclusively in cortical regions.
Subconjunctival injections of SM-345431 promoted a robust network of regenerating nerves as well as functional recovery of corneal sensation in a mouse keratoplasty model, suggesting a novel therapeutic strategy for treating neurotrophic corneal disease.