Do genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene?
Deletion of 14q is a frequent event in clear cell renal carcinoma and portends a poor prognosis. In this study, we provide genetic and functional evidence that HIF1α is a target of 14q loss in kidney cancer.
Our results suggest that serum indoxyl sulfate level was a valuable marker in predicting cardiovascular disease and renal function decline in patients with advanced chronic kidney disease.