Does lipopolysaccharide pretreatment promote cardiac stem cell migration through heat shock protein 90-dependent β-catenin activation?
The results suggested that low dose of LPS pretreatmemt induced increased CSC migration, reduced the infarct size of ischemia-reperfusion heart. The mechanism might be due to the activation and translocation of β-catenin via HSP90-dependent manner.
These findings indicate that atorvastatin inhibits fructose-induced ChREBP activity and increases CPT-I expression by activating PKA.