Does regulation of renal sympathetic neurotransmission by renal α ( 2A ) -adrenoceptors is impair in chronic renal failure?
In our model of renal failure autoregulation of renal sympathetic neurotransmission was impaired. Presynaptic inhibition of noradrenaline release was diminished and the facilitatory effect of presynaptic angiotensin AT₁ receptors on noradrenaline release was markedly decreased in renal failure and depended on functioning α(2A)-adrenoceptors.
The extent of viable myocardium with disturbed sympathetic innervation was greater in patients with low heart rate variability as compared to those with normal heart rate variability 3 mo after myocardial infarction.