Does inhibition of glycogen synthase kinase-3β suppress inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes and collagen-induced arthritis?
Treatment with GSK-3β inhibitors suppressed inflammatory responses in RA FLS and CIA mice. These findings suggest that the inhibition of GSK-3β can be used as an effective therapeutic agent for RA.
These data suggest that independent of age, gender, and neck size, objective anatomical assessment can significantly differentiate those with mild versus moderate-to-severe OSA in a clinical setting, and may have utility as a component in stratifying risk of OSA.