Do platelets contribute to enhanced MCP-1 levels in patients with chronic heart failure?
Platelets can contribute to enhanced MCP-1 levels in CHF. MCP-1 is markedly elevated in serum of CHF patients showing a direct correlation with the severity of symptoms and the degree of left ventricular dysfunction. Further studies are required to test whether MCP-1 blocking or sophisticated anti-platelet strategies may represent new therapeutic options in CHF.
Preexisting sequence variation could alter the effect of cyclosporine on HCV in vivo.