Does interleukin-6 protect hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression?
IL-6 may be hepatoprotective in acute injury through down-regulation of MMP-2. These findings suggest a role for MMP-2 in amplifying liver injury in vivo.
The study gives no definite evidence for a pathogenic genetic link of periodontitis and RA but suggests IRF5 and PRDM1 as shared susceptibility factors.