Does heme oxygenase-1 prevent liver fibrosis in rats by regulating the expression of PPARγ and NF-κB?
Our data demonstrate a potential mechanism that HO-1 can prevent liver fibrosis by enhancing the expression of PPARγ and decreasing the expression of NF-κB in liver tissues.
The surgical patient should be evaluated according to age and the presence of unerupted/impacted third molars. Prevention is focused on adequate osteotomy design, eliminating sharp angle where abnormal stress occurs on bony segments, completion of adequate cuts into the retrolingular depression and through the inferior border, and careful separation of the segments. The SSO is an extremely technical and sensitive procedure, and careful attention will probably prevent most unfavorable splits. If a fracture occurs, the fractured segments should be incorporated into the fixation scheme if possible. The occurrence of bad splits cannot always be avoided. When adequately treated the chances of functional success are good.