Does haemoxygenase modulate cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury?
RIPC protects hepatic microcirculation by induction of HO and modulation of CINC in hepatic IR.
Tobacco plants are able to correctly process viral and murine IL-10 into biologically active dimers, therefore representing a suitable platform for the production for these cytokines. The accumulation levels obtained are high enough to allow delivery of an immunologically relevant dose of IL-10 in a reasonable amount of leaf material, without extensive purification. This study paves the way to performing feeding studies in mouse models of autoimmune diseases, that will allow the evaluation the immunomodulatory properties and effectiveness of the viral IL-10 in inducing oral tolerance compared to the murine protein.