Is [ 3H ] muscimol binding to gamma-aminobutyric acid ( A ) receptors upregulated in CA1 neurons of the gerbil hippocampus in the ischemia-tolerant state?
Downregulation of ligand binding to glutamate receptors in relatively ischemia-resistant CA3 and dentate gyrus neurons destined to survive suggests marked synaptic reorganization processes despite maintained structural integrity. More importantly, upregulation of binding to inhibitory GABA(A) receptors in the hippocampus indicates a relative shift between inhibitory and excitatory neurotransmission that we suggest may participate in endogenous postischemic neuroprotection.
Occlusal force resulted in increased NOS expression. NO may mediate changes in PDL structure in response to occlusal force.