Is in the absence of ( early ) invasive carcinoma , vulvar intraepithelial neoplasia associated with lichen sclerosus mainly of undifferentiated type : new insights in histology and aetiology?
VIN related to LS without coexisting SCC is likely to be undifferentiated, in contrast to what was previously thought. HPV DNA was demonstrated in 31% of the lesions, and was strongly related to high-grade VIN.
Our results demonstrate the prognostic relevance of tumor proliferation in recurrent melanoma patients. Data also support restratification of risk assessment upon recurrence that considers tumor biology in addition to clinical variables evaluated as part of the standard of care.