Does dNA aptamer raised against advanced glycation end products inhibit neointimal hyperplasia in balloon-injured rat carotid arteries?
The present study suggests that AGE-aptamer could prevent balloon injury-induced neointimal hyperplasia by reducing PDGF-BB and macrophage infiltration via suppression of the AGE-RAGE-mediated oxidative stress generation. AGE-aptamer might be a novel therapeutic strategy for suppressing neointima formation after balloon angioplasty.
These findings demonstrate that those mice treated with a clinically relevant dose of morphine sulfate after an "immunologically insignificant" burn displayed immunosuppression and a Th-2 cytokine profile. Thus, the therapeutic administration of exogenous opiates appears to contribute to the development of post-burn immune dysfunction.