Is salivary cortisol release and hypothalamic pituitary adrenal axis feedback sensitivity in fibromyalgia associated with depression but not with pain?
The presented data suggest depression to be an important factor in HPA axis-related dysfunction in fibromyalgia. This might be one explanation for equivocal findings in the literature.
Hypoxia within the physiological range releases ATP from HUVEC, particularly from apical/adluminal surfaces by exocytosis, via an increase in [Ca(2+)]i, PI3K and ROCK, independently of NO. We propose that hypoxia releases ATP at concentrations sufficient to induce umbilical vein dilation via PGs and NO and improve fetal blood flow, but curbs amplification of ATP release by autocrine actions of ATP, so limiting its pro-inflammatory effects.