Mucinous cystic neoplasm of the pancreas: is surgical resection recommended for all surgically fit patients?
MCNs had a low prevalence of malignancy. Regardless of the histological grade, long-term outcome was excellent. Therefore, in the absence of specific symptoms, surgery may not be indicated for MCNs<3 cm without mural nodules or elevated serum tumor markers. Validation by a prospective study with very careful design is needed.
Card15/Nod2 deficiency induces an abnormal development and function of the PPs characterised by an exaggerated immune response and an increased permeability. These observations provide a comprehensive link between the molecular defect and the Human CARD15/NOD2 associated disorders: CD and GVHD.