Is c-Met expression a marker of poor prognosis in patients with locally advanced head and neck squamous cell carcinoma treated with chemoradiation?
c-Met is expressed in the majority of locally advanced HNSCC cases, and high c-Met expression predicts for worse clinical outcomes. High c-Met expression predicted for worse DFS in p16-negative patients but not in p16-positive patients. c-Met predicted for worse outcome regardless of EGFR status.
These results suggest that chronic HCV infection is not a strong promoter of breast carcinoma in adult females of any age.