Does after Intestinal Transplantation Kidney Function be Impaired by Downregulation of Epithelial Ion Transporters in the Ileum?
Our data strongly suggest that tacrolimus impairs absorption of NaCl and water from the transplanted ileum, leading to volume depletion and impaired renal function. This may be reversible by reduction of tacrolimus to lower levels without increased rates of rejection or chronic graft failure.
Our findings do not support the hypothesis that ARBs increase the risk of MI.