Does oral therapy with proteolytic enzymes decrease excessive TGF-beta levels in human blood?
These results support the concept that OET is beneficial in diseases characterized in part by TGF-beta1 overproduction.
Our data indicate that HDAC inhibitors downregulate Gnrh1 gene expression via repressing Otx2-driven transcriptional activity. This study should provide an insight for our understanding on the effects of HDACs in the reproductive system and suggests that HDACs could be potential novel targets for the therapy of GnRH-related diseases.