Does melatonin abate liver ischemia/reperfusion injury by improving the balance between nitric oxide and endothelin?
Pretreatment with melatonin increased NO bioavailability and decreased endothelin expression, and consequently played a protective role in preserving both liver function and structure during ischemia and reperfusion injury.
The results of our study allow us to confirm our starting hypothesis. Statistical analysis highlights that preoperative data are significantly different for the three types of hysterectomies, both as urethral mobility values (analysis of variance P<or=0.0001) and as relative frequency of patients at higher risk of pelvic statics alterations (chi2 test P<or=0.0001).