Does targeting filamin A reduce K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice?
We conclude that FLNA is important for lung tumor growth and that endothelial Flna impacts local tumor growth. The data shed new light on the biological importance of FLNA and suggest that targeting this protein might be useful in cancer therapeutics.
We cannot exclude the risk of false positive errors due to the relatively small sample sizes.