Does gamma-aminobutyric acid type A receptor beta 2 subunit mediate the hypothermic effect of etomidate in mice?
The GABAA receptor beta 2 subunit mediates a significant proportion of the hypothermic effects of etomidate. As the beta 2 subunit mediates postrecovery ataxia and sedation, anesthetic agents that do not have in vivo potency at beta 2 subunit-containing receptors offer the potential for surgical anesthesia with improved recovery characteristics.
The results reported above show that FLT3 mutations and MDR1 expression represent two independent clinical prognostic factors for AML patients.