Is [ Causes of socioeconomic group-related mortality in the Federal Republic of Germany -- tobacco consumption the predominant risk factor ]?
This paper investigates the four most common hypotheses for the internationally well-documented phenomenon of socioeconomic group-related mortality on the basis of nationwide German longitudinal data. Regular nicotine consumption is by far the most significant controllable risk factor for mortality in both genders.
Younger age and the presence of CYP2C19 gain-of-function alleles were associated with subtherapeutic voriconazole concentrations. Starting doses based on age and CYP2C19 status could increase the number of patients achieving therapeutic voriconazole exposure.