Are polymorphisms within Toll-like receptors associated with systemic lupus erythematosus in a cohort of Danish females?
These results obtained from a female lupus population of Danish ancestry suggest that variations in TLR3, TLR8 and TLR9 genes are implicated in the pathogenesis of the disease. If these polymorphisms are associated with innate immune dysfunction they may add to the growing field of theoretically well founded new therapeutic targets.
National pediatric intensivists identified the same drug strategy to obtain analgesia and sedation in their patients, according to last published guidelines. Assessment of analgesia and sedation was more diffuse but not regularly performed and different methods were used. Withdrawal syndrome was monitored in a minority of contacted centres. Considering our data the practice of analgesia and sedation in Italian Pediatric Intensive Care Units is improved but not yet completely adherent to last international recommendations.