Do advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes?
Early glycation and AGE residue content of endoneurial ECM proteins increase markedly in STZ-induced diabetes. Glycation of laminin and fibronectin causes a reduction in neurotrophin-stimulated neurite outgrowth and preconditioned neurite outgrowth. This may provide a mechanism for the failure of collateral sprouting and axonal regeneration in diabetic neuropathy.
The Schiotz tonometer has the highest accuracy of IOP compared with the Tono-pen and gold standard digital manometry. Clinicians could consider Schiotz tonometry when measuring IOP in patients with keratoprosthesis.