Does a bioavailable cathepsin S nitrile inhibitor abrogate tumor development?
In summary, these results highlight the characterisation of this nitrile cathepsin S inhibitor using in vitro and in vivo tumor models, presenting a compound which may be used to further dissect the role of cathepsin S in cancer progression and may hold therapeutic potential.
We conclude that AMPK activation is required for resveratrol to improve endothelial function in diabetic mice.