Does dietary arginine supplementation attenuate renal damage after relief of unilateral ureteral obstruction in rats?
Dietary ARG supplementation during UUO relief did not improve ERPF or GFR. However, renal damage, including fibrosis, apoptosis, and macrophage infiltration was significantly improved by ARG treatment. This suggests that increasing NO availability could be beneficial in the setting of UUO relief.
Based on the physiopathology put forward to account for the aetiological factors of diseases such as Parkinson, Alzheimer or post-traumatic epilepsy, we found reasons to consider severe TBI to be another predisposing factor of delayed ischemic stroke, with all the implications this involves in medical-legal matters. More extensive case mixes will be needed in order to confirm our proposition.