Is 0.03 % Tacrolimus ointment applied once or twice daily more efficacious than 1 % hydrocortisone acetate in children with moderate to severe atopic dermatitis : results of a randomized double-blind controlled trial?
0.03% tacrolimus ointment applied once or twice daily is significantly more efficacious than 1% HA in treating moderate-severe AD in children. Twice daily application of 0.03% tacrolimus ointment results in the greatest improvement in mEASI, and is especially effective in patients with severe baseline disease.
These data demonstrate that captopril partially inhibits the changes in the neonatal rabbit bladder associated with obstruction, supporting the hypothesis that angiotensin II is involved in the regulation of bladder smooth muscle growth and collagen production.