Does valproic Acid prolong survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts?
We have developed intracerebellar orthotopic models that closely recapitulated the biological features of human medulloblastomas and characterized their in vivo growth characteristics. Valproic acid treatment of these xenografts showed potent in vivo anti-medulloblastoma activity. These xenograft models should facilitate the understanding of medulloblastoma pathogenesis and future preclinical evaluation of new therapies against medulloblastoma.
Maximal leg-strength training improves cycling economy in previously untrained subjects. Increases in leg strength during the final 4 wk of training with unchanged LLM suggest that neural adaptations were present.