Does miR-34a attenuate paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms?
MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance, all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer.
These results suggest that a change in SEP in young adulthood is an important predictor of BMI, independent of childhood SEP.