Does inhibition of lipolysis during acute GH exposure increase insulin sensitivity in previously untreated GH-deficient adults?
The study of acute administration of GH to previously untreated GHD patients provides compelling evidence that (i) GH-induced insulin resistance is mainly due to induction of lipolysis by GH; and (ii) inhibition of lipolysis can prevent the deterioration of insulin sensitivity. The question remains whether GH replacement therapy should, at least at the beginning of therapy, be combined with means to prevent an excessive stimulation of lipolysis by GH.
HK2 is a promising treatment target for NSCLC with Kras activating and p53 function loss.