Does medial medullary infarct aggravate central poststroke pain caused by previous lateral medullary infarct?
This observation has implications regarding the pathogenesis of CPSP. CPSP may be related to hyperexcitation of the spinothalamic pathway by the reticulothalamic system, which in turn is modulated by the medial lemniscus pathway.
These results indicate that hypokalemic renal injury is mediated, at least in part, by Ang II via the Ang II type 1 receptor, with a lesser contribution mediated by a reduction in nitric oxide. Losartan may be beneficial in preventing hypokalemic tubulointerstitial injury.