Does transmembrane activator and CAML interactor ( TACI ) haploinsufficiency result in B-cell dysfunction in patients with Smith-Magenis syndrome?
Our findings suggest that haploinsufficiency of the TACI gene results in humoral immune dysfunction, highlighting the role of genomic copy number variants in complex traits.
The combination of mitoxantrone/etoposide and imatinib is well tolerated, with mild nonhematologic toxicity even in older patients. Eligible patients benefit from allo-SCT after response to the induction treatment.