Are serine residues 994 and 1023/25 important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta?
The data suggest that the HIR-domain which contains the serine residues 994 and 1023/25 is important for the inhibitory effect of protein kinase C isoforms beta2 and theta on insulin receptor autophosphorylation.
CS is associated with intestinal barrier dysfunction in the small intestine but not in the large intestine of mice.