Does natural cardiogenesis-based template predict cardiogenic potential of induced pluripotent stem cell lines?
Transcriptome analysis attuned to natural embryonic cardiogenesis provides a robust platform to probe coordinated cardiac specification and maturation from bioengineered stem cell-based model systems. A panel of developmental-related genes allowed differential prognosis of cardiogenic competency, thus prioritizing cell lines according to natural blueprint to streamline functional applications.
Attitude toward mental disorders is an important trait of relatives supporting mentally ill persons. Differences in the effects of disorder-specific attitudes on relatives' well-being and their perception of burden have to be investigated further to enable the development of supportive strategies suited to the various groups of psychiatric patient relatives.