Are sex , ethnicity , and slow acetylator profile the major causes of hepatotoxicity induced by antituberculosis drugs?
This study showed that a patient's NAT-2 acetylator status, gender, and ethnic origin may be regarded as important risk factors for developing hepatotoxicity. Contrary to expectations, the CYP2E1 c1/c2 polymorphism did not show a significant association with hepatotoxicity in this study. Given the increases in TB cases and ATDH incidence levels, as well as the associated hospitalization costs, it may also be helpful to know patients' acetylator status prior to or at the beginning of the TB treatment regimen.
Our findings suggest that elevated levels of PCNT2 might be implicated in the pathophysiology of bipolar disorder.