Does overexpression of human decoy receptor 3 in mice result in a systemic lupus erythematosus-like syndrome?
These results show that DcR3 overexpression could lead to an SLE-like syndrome in mice.
This study demonstrates that RA patients have increased aortic (18)F-fluorodeoxyglucose uptake in comparison with patients who have stable cardiovascular disease. Anti-tumor necrosis factor-α therapy reduces aortic inflammation in patients with RA, and this effect correlates with the decrease in aortic stiffness. These results suggest that RA patients exhibit a subclinical vasculitis, which provides a mechanism for the increased cardiovascular disease risk seen in RA.