Does atorvastatin increase ecNOS levels in human platelets of hyperlipidemic subjects?
This study adds to the volume of evidence that statins have beneficial effects other than lipid lowering. Here, Atorvastatin is shown to significantly elevate intraplatelet ecNOS levels in hyperlipidemic subjects without affecting iNOS expression. The net result of this would be the elevation of NO production which would promote platelet deaggregation and vasodilation.
Patients demonstrated to have glaucoma and facial PWS are approximately 7 times more likely to have multiple dermatomes of the trigeminal nerve involved (88.3%) in contrast to isolated V(1) involvement (9.3%). PWS patterns did not correlate with embryological segments of facial development. A review of the relevant literature resolves conflicting concepts and emphasizes the importance of glaucoma screening in all patients with trigeminal dermatome involvement of the PWS.