Does volatility of serum creatinine relative to tacrolimus levels predict kidney transplant rejection?
Increased volatility of SCr relative to [Tac] is associated with an increased risk of rejection. Whereas increased variation in [Tac] levels has been shown to indicate reduced adherence, increased VCT may signal 'immunologic unrest' in the graft. Further studies are warranted to determine if intervention at the time when volatility increases can lower the risk of an acute rejection episode.
One week of creatine supplementation (25 g/day) enhances muscular performance during repeated sets of bench press and jump squat exercise.