Is serum interleukin-18 level associated with the outcome of patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP regimens?
Serum IL-18 might be a powerful prognostic factor for DLBCL in R-era.
The GnRH-pulse generator is very radiosensitive as low dose irradiation causes precocious puberty, whereas high dose irradiation is associated with delayed sexual maturation. Radiation induced precocious puberty might be caused by damage to inhibitory GABAergic neurons leading to desinhibition and premature activation of GnRH neurons. Our animal model of cranial irradiation seems to be suitable to study neurotransmitter disorders, molecular mechanisms and potential preventive intervention of radiation induced pubertal changes.