Is [ Th17/Treg unbalance involved in the pathogenesis of experimental autoimmune encephalomyelitis ]?
Th17/Treg unbalance may be involved in the pathogenesis of EAE.
The role of PLA(2)R as a major antigen in iMN was confirmed in an independent, European patient cohort, and levels of circulating anti-PLA(2)R revealed a strong correlation with clinical disease activity. We propose that detection and measurement of these autoantibodies may provide a tool for monitoring of disease activity and treatment efficacy.