Is lipodystrophy in HIV-1-positive patients associated with insulin resistance in multiple metabolic pathways?
Post-absorptive glucose production is increased in HIV-1-infected patients with lipodystrophy. Moreover, both the ability of insulin to suppress endogenous glucose production and lipolysis, and to stimulate peripheral glucose uptake and its metabolic pathways is reduced, indicating severe resistance concerning multiple effects of insulin.
Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats.