Is the silencing of microRNA 148a production by DNA hypermethylation an early event in pancreatic carcinogenesis?
We show that the hypermethylation of the DNA region encoding miR-148a is responsible for its repression in PDAC precursor lesions and can be a useful tool for the differential diagnosis of PDAC and CP.
Considering the risk of quinolone-resistance in pneumococci, the observation might be of clinical importance.