Does manganese superoxide dismutase polymorphism affect the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery disease?
Our data indicate that the alanine variant of signal peptide increases the mitochondrial MnSOD activity, protects macrophages against the oxLDL-induced apoptosis, and reduces the risk of CAD and AMI.
These findings demonstrate that FXR agonists may be useful for the treatment of non-alcoholic steatohepatitis.