Is cytotoxic sensitivity to tumor necrosis factor-alpha in PC3 and LNCaP prostatic cancer cells regulated by extracellular levels of SGP-2 ( clusterin )?
These results suggest that SGP-2 can act as an extracellular mediator of anti-TNF-induced cytotoxicity.
Our results are in concert with earlier studies describing the induction of glutamate transport by ethanol. Enhanced expression of EAAT1 and EAAT2 after ethanol exposure can be viewed as a maladaptive process that disposes the developing brain to fetal alcohol syndrome.