Does partial loss of VE-cadherin improve long-term outcome and cerebral blood flow after transient brain ischemia in mice?
Partial loss of VE-cadherin results in long term stroke protection. On the cellular and molecular level, this effect appears to be mediated by improved endothelial/pericyte interactions and the resultant increase in cerebral blood flow. Our study reinforces accumulating evidence that long-term stroke outcome depends critically on vascular mechanisms.
The EGF/EGFR axis triggers EMT in CCA cells highlighting the key role of this pathway in CCA progression.