Does ipsilateral varus knee alignment correlate with increased femoral stem anteversion in primary total hip arthroplasty?
The ipsilateral knee varus deformity should be considered to optimise the femoral component position during contemporary total hip arthroplasty.
We hypothesise that loss of response to melatonin treatment can be caused by slow metabolisation of exogenous melatonin. As melatonin is metabolised in the liver almost exclusively by cytochrome P450 enzyme CYP1A2, this slow melatonin metabolism is probably due to decreased activity/inducibility of CYP1A2. In patients with loss of response to melatonin, a melatonin clearance test should be considered and a considerably dose reduction is advised.