Are filaggrin gene defects independent risk factors for atopic asthma in a Polish population : a study in ECAP cohort?
In a Polish population FLG 2282del4 and R501X carriage increases risk for development of AD and atopic asthma (also in the absence of AD or history thereof). This suggests that interventions aimed at restoring epidermal barrier may have a general role in asthma prophylaxis/treatment.
The present results provide novel evidence that the reduced GLP-1R expression in SHR renal arteries is most likely mediated through PKCβ upregulation; the latter probably contributes to the impaired GLP-1R-mediated vasorelaxations in hypertension.