Does glycyrrhizin protect against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms?
Gly blocks infarction by inhibiting IFNγ-mediated T cell activity, which is at least partly modulated by HMGB1 activity.
The consensus of this group of experts is that the economic evaluation of diagnostics-based PM may not require a new paradigm. However, greater complexity means that existing approaches and tools may require improvement to undertake these more analyses.