Is 24-norUrsodeoxycholic acid superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 ( Abcb4 ) knockout mice?
24-norUrsodeoxycholic acid ameliorates sclerosing cholangitis in Mdr2(-/-) mice. Its therapeutic mechanisms involve (1) increasing the hydrophilicity of biliary bile acids, (2) stimulating bile flow with flushing of injured bile ducts, and (3) inducing detoxification and elimination routes for bile acids.
The results of the presented study indicate that CAD does not influence stroke recurrence.