Does inactivation of specific Pseudomonas aeruginosa biofilm factors alter virulence in infected cholesteatomas?
Our hypothesis that biofilm formation is a virulence factor in cholesteatomas infected with P. aeruginosa was not supported. A number of interpretations of these data are reasonable. It is possible that biofilms are not critical in infected cholesteatomas. Alternatively, the mutants that are deficient in generating biofilms in vitro may be able to form effective biofilms in vivo using alternative pathways.
Vitamin D deficiency is common in patients after TBI and associated with impaired cognitive function and more severe depressive symptoms.