Is weekly bortezomib , pegylated liposomal doxorubicin , and dexamethasone a safe and effective therapy for elderly patients with relapsed/refractory multiple myeloma?
Bortezomib/ PLD/dexamethasone combination is safe and effective in elderly patients with resistant-relapsing MM.
Ethanol-induced HMGB1/TLR signaling contributes to induction of the proinflammatory cytokine, IL-1β. Increased expression of HMGB1, TLR2, TLR3, and TLR4 in alcoholic brain and in mice treated with ethanol suggests that chronic alcohol-induced brain neuroimmune activation occurs through HMGB1/TLR signaling.