Is foot process effacement an early marker of nephropathy in young classic Fabry patients without albuminuria?
Podocyte foot process effacement was found in the majority of eight young classical Fabry patients of both genders after the age of 11 years, without clinical signs of Fabry nephropathy. Kidney biopsies are essential in the early diagnosis of nephropathy and in the evaluation of the response to enzyme replacement therapy of early Fabry nephropathy.
Our data suggest that a substantial body weight loss per se does not affect olfactory perception. However, our results point towards improved olfactory perception after sleeve gastrectomy but not Roux-en-Y gastric bypass.