Is downregulation of HNF-1B in renal cell carcinoma associated with tumor progression and poor prognosis?
The level of HNF-1B mRNA expression significantly decreases with tumor progression, and patients with high HNF-1B mRNA levels have a significantly better prognosis. HNF-1B might be a useful prognostic factor for metastatic RCC and also a potential therapeutic target in the future.
Regular conduct of board rounds in a medium-sized UK ED is worthwhile and provides an additional teaching opportunity for juniors.