Does inhibition of mammalian target of rapamycin aggravate the respiratory burst defect of neutrophils from decompensated patients with cirrhosis?
mTOR significantly up-regulates the PMN RB of patients with cirrhosis by p38-MAPK activation. Consequently, mTOR inhibition by rapamycin dramatically aggravates their PMN RB defect, which may increase patients' susceptibility to infection. Thus, concerns should be raised about the use of rapamycin in immuno-depressed patients.
Awake ECMO bridging for retransplantation provides comparable results to elective retransplantation.