Does a furanocoumarin-free grapefruit juice establish furanocoumarins as the mediators of the grapefruit juice-felodipine interaction?
Furanocoumarins are the active ingredients in GFJ responsible for enhancing the systemic exposure of felodipine and probably other CYP3A4 substrates that undergo extensive intestinal first-pass metabolism.
Early ST variability detectable in real time is associated with worse outcome.