Does angiotensin-converting enzyme inhibition increase human vascular tissue-type plasminogen activator release through endogenous bradykinin?
ACE inhibition increases constitutive endothelial t-PA release through endogenous bradykinin.
Our findings show that although pluripotent cells with teratocarcinogenic potential can be produced in vitro by the overexpression of pluripotency regulators in explanted somitogenesis-stage somatic cells, the in vivo induction of these genes does not yield tumours. This suggests a restrictive regulatory role of the embryonic microenvironment in the induction of pluripotency.