Effects of surgical manipulation on coronary stents: should surgical strategy be altered?
The findings from this study indicate that once the need for surgical revascularization arises, a previously stented coronary artery should be bypassed even if the angiographic findings are normal, because of the likelihood that manipulation during an open heart operation will result in significant deformity or obliteration of the stent.
Endogenous eATP produced by P. aeruginosa serves as a signalling molecule to co-ordinate complex multicellular behaviours of this pathogen. Given the propensity for P. aeruginosa to infect damaged epithelial tissues, our observations suggest that eATP released by damaged cells may provide a cue to reduce twitching motility of P. aeruginosa in order to establish infection at the site of damage. Furthermore, eATP produced by P. aeruginosa biofilms and by damaged epithelial cells may play a role in P. aeruginosa pathogenesis by inducing inflammatory damage and fibrosis. Our findings have significant implications in the development and pathogenesis of P. aeruginosa biofilm infections.