Does overproduced interleukin 6 decrease blood lipid levels via upregulation of very-low-density lipoprotein receptor?
Overproduced IL6 decreased blood lipid levels by increasing VLDLR expression in several tissues. It is concluded that IL6 blockade normalises reduced lipid levels caused by IL6, but does not affect normal lipid metabolism.
Our findings suggest that GOLPH3 expression status may be a potential prognostic biomarker and therapeutic target in PCAC.