Does review suggest that cleft lip and palate patients have more caries?
Individuals with CLP, when compared with matched non-CLP controls, tend to have a higher prevalence of dental caries, as detected using the decayed, missing and filled index. This holds true both for permanent and for deciduous teeth. One must keep in mind, however, that relatively few studies were included in the present meta-analysis, and the reporting on the methods in the individual studies was not always transparent.
The degree of tachyphylaxis with beta-agonists is dependent on and increases with the gestational age of the target tissue. beta-Agonist type was not an important determinant of the duration of inhibitory response. We speculate that the effect of gestational age on tachyphylaxis may be related to increased myometrial expression of inactivating beta-adrenergic receptor kinases.