Do mechanosensation and maximum bite force in edentulous patients rehabilitated with bimaxillary implant-supported fixed dental prostheses?
IFDP/IFDPs are a valuable treatment option for restoring edentulous patients. Limitations concerning their physiological integration into the orofacial system are mainly related to a poor passive rather than active tactile sensitivity or maximum bite force.
This is the first report showing that human macrophages isolated directly from periprosthetic tissues surrounding loosened implants can differentiate into multinucleated cells showing all the functional and cytochemical characteristics of osteoclasts. In contrast with other macrophage populations, exogenous M-CSF is not required for this to occur. In the context of the heavy macrophage response to wear particles in periprosthetic tissues macrophage-osteoclast differentiation may represent an important cellular mechanism whereby osteolysis is effected in aseptic loosening.