Are aBCA1 mutation carriers with low high-density lipoprotein cholesterol characterized by a larger atherosclerotic burden?
Carriers of loss of function ABCA1 mutations display a larger atherosclerotic burden compared with age and sex-matched controls, implying a higher risk for CVD. Further studies are needed to elucidate the full function of ABCA1 in the protection against atherosclerosis. These data support the development of strategies to up-regulate ABCA1 in patients with established CVD.
The preservation of the PCL was not helpful for improving kinematics and clinical outcome in highly conforming mobile-bearing TKA.