Are the long-term time trends of peptic ulcer and ulcerative colitis interrelated?
The sudden rise of peptic ulcer disease during the 19th century and the 10-20-yr time lag between gastric and duodenal ulcer are difficult to explain based on changing infection rates with Helicobacterpylori alone. The similarity between the time trends of duodenal ulcer and ulcerative colitis suggests the influence of one or more shared risk factors.
HS treatment may ameliorate the tissue damage induced by intestinal I/R. This protective effect is possibly due to its ability to activate the CD4(+) and CD8(+) T-lymphocytes cells in the intestinal tissues and inhibit the intestinal I/R-induced expression of pro-inflammatory cytokines.