Does a focused in situ hybridization screen identify candidate transcriptional regulators of thymic epithelial cell development and function?
Our studies have identified two developmental transcription factors that are excellent candidate regulators of thymic epithelial cell specification and differentiation during fetal development. Our results suggest that Foxg1 and Isl1 may play a role in the regulation of TEC differentiation during fetal and postnatal stages. Our results also demonstrate heterogeneity of TECs marked by the differential expression of transcription factors, potentially providing new insights into the regulation of TEC differentiation.
OC use in extremely low birthweight infants is associated with nasal mucosal injury and bleeding. Studies are needed to see if use of OCs is a risk factor for CNSS.