Is neuroprotective effects of Paeonia Lactiflora extract against cell death of dopaminergic SH-SY5Y cells mediated by epigenetic modulation?
The results suggested that MPP(+)-induced cell death in the dopaminergic SH-SY5Y cells was related with transcriptional induction of HATs and increased histone H3 acetylation and that PLE might prevent the cells from MPP(+)-induced cell death via tempering histone H3 acetylation.
In the case of patients on multiple medication, the doctor must try to establish simple dosage patterns (once or twice a day) of the most efficient efficacious medication.