Does tranilast attenuate myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats?
Myocardial fibrosis seen in DOCA/salt hypertensive rats might be associated with the inflammation/wound healing response. Tranilast suppresses both infiltration of monocytes/macrophages and myocardial fibrosis.
A cyclic respiratory pattern occurs commonly in patients with mild to moderate heart failure. It is related to poor left ventricular systolic function and not related to clinical status or etiology of heart failure. The cyclic respiratory pattern found commonly in patients with compensated heart failure and very poor ventricular function (ejection fraction<25%) consists of a variation in tidal volume only. Respiratory rate is relatively constant and true apnea does not occur.