Are interferon regulatory factor 5 genetic variants associated with cardiovascular disease in patients with rheumatoid arthritis?
Our results reveal that IRF5 gene variants are associated with risk of CV events in patients with RA.
Thus, alteration of Cl- transport by bumetanide enables the anticonvulsant action of phenobarbital in immature brain. This is a mechanistic demonstration of rational anticonvulsant polypharmacy. The combination of these agents may comprise an effective therapy for early-life seizures.