Does candesartan inhibit Toll-like receptor expression and activity both in vitro and in vivo?
Pam3CSK4 and LPS induced TLR2 and TLR4 expression at mRNA and protein levels are inhibited by candesartan both in vitro and in vivo. Thus, we define a novel pathway by which candesartan could induce anti-inflammatory effects.
This study demonstrates that assistive devices can greatly reduce the forces required to move seated subjects horizontally. The sliding board and the fabric tube were most effective when used together. Such devices have the potential to make transfers easier for individuals performing seated transfers and to reduce the risk of injury among individuals assisting them.