Does transfection with CD40L induce tumour suppression by dendritic cell activation in an orthotopic mouse model of pancreatic adenocarcinoma?
The induction of anti-tumour activity initiated after treating mice with the CD40L plasmid was achieved. Further investigations showed that this is mediated by mature myeloid dendritic cells which activate CD8 cells. Clinical trials investigating CD40L-based therapies should be extended.
Higher HSV, not HSD, is significantly associated with abdominal obesity, which can be partially explained by increased caloric intake, especially from carbohydrate, in adolescents. This study suggests that more attention should be paid to establish and maintain regular sleep patterns in adolescents.