Outcome of carotid endarterectomy in African Americans: is race a factor?
CEA can be accomplished with acceptable morbidity and mortality in black patients with an expectation of similar protection from ipsilateral ischemic stroke as in white patients. Black patients, however, have a higher incidence of all strokes at long-term follow-up due to the higher risk of stroke in patients with symptoms of carotid bifurcation disease.
We suggest that EBNA-3 by direct protein-protein interaction induces the nuclear accumulation of a novel enzyme, that is part of the ribonucleotide salvage pathway. Increased intranuclear levels of UK/UPRT may contribute to the metabolic build-up that is needed for blast transformation and rapid proliferation.