DNA measurement on histologic slides. Does it work on human tissue?
Reliable results can be obtained only when knowing the exact section thickness. In very thin sections the method of Bins leads to reliable results; in medium-thick sections the methods of McCready and Haraske result in correct ploidy values. Sections thicker than 7 microns do not need histogram correction.
Our method provides a new imaging modality to facilitate clinical diagnosis. It also provides a way to validate/correlate cellular MRI data used for tracking immune-cell infiltration in cardiac transplant rejection and cardiac ischemic injury.