Is cyclo-oxygenase-2 overexpression a feature of early and well-differentiated hepatocellular carcinoma with a favourable prognosis?
Overexpression of COX-2 in HCC indicates early-stage cancer with less aggressive tumour behaviour and constitutes an independent prognostic factor.
Our findings indicate NIr to be an effective therapeutic agent in a primate model of the disease and create the template for translation into clinical trials.