Does deficiency of vasodilator-stimulated phosphoprotein ( VASP ) increase blood-brain-barrier damage and edema formation after ischemic stroke in mice?
Our study identifies VASP as critical regulator of BBB maintenance during acute ischemic stroke. Therapeutic modulation of VASP or VASP-dependent signalling pathways could become a novel strategy to combat excessive edema formation in ischemic brain damage.
Administration of the inhibitor of Src family kinases could decrease the expression of mRNA and protein of Nav1.1 in spiral ganglion neurons.