Are bone marrow monocyte/macrophages an early cellular target of pathogenic and nonpathogenic isolates of simian immunodeficiency virus ( SIVmac ) in rhesus macaques?
We conclude that bone marrow monocyte/macrophages are an important early cellular target in SIV infection regardless of viral pathogenicity and in vitro cellular tropism. SIV-infected bone marrow monocyte/macrophages may play a key role in the pathogenesis of bone marrow lesions and further dissemination and persistence of virus infection.
Our finding indicates that ethanol induces ER stress in immature neurons, providing novel insight into ethanol's detrimental effect on the developing CNS.