Is p53 expression in human carotid atheroma significantly related to plaque instability and clinical manifestations?
The increased p53 expression, particularly macrophage p53 levels, is associated with the enlargement of necrotic cores, plaque rupture and clinical manifestations of carotid plaques. Concomitant increases of lysosomal cathepsin, ferritin, and p53 levels may promote the apoptosis and atheroma progression in patients with carotid atherosclerosis.
This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.