Does deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen result in a mild metabolic phenotype?
These results argue against the possibility of G6PC2 playing a major role in pancreatic islet stimulus secretion coupling or energy homeostasis under physiological conditions imposed by conventional animal housing. This indicates that manipulating the expression of G6PC2 for therapeutic ends may be feasible.
Volunteering is associated with reduced mortality in older adults in England, but this effect appears to be limited to volunteers who report no disabilities.