Does nitrous oxide exposure seem to be associated with increased mortality , stroke , and myocardial infarction : a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery ( GALA ) trial?
Given the greater prevalence of vascular risk factors in the nitrous oxide group and the lack of any definite effect on the primary outcome measure, these data do not support a clinically meaningful adverse effect of nitrous oxide on our composite outcome in patients undergoing carotid surgery.
These results provide further evidence that chronic antidepressant treatment can impair amygdala-dependent learning. Our findings are consistent with a role for glutamatergic neurotransmission in the final common pathway of antidepressant treatment.