Does low-dose protamine based on heparin-protamine titration method reduce platelet dysfunction after cardiopulmonary bypass?
Low-dose administration of protamine, based on a heparin-protamine titration method, restores not only the blood coagulation but also the platelet responses to thrombin and attenuates platelet alpha-granule secretion during heparin neutralization. Overdose of protamine activates platelets and may predispose patients to excessive bleeding after cardiac surgery.
NBI seems to be useful and reliable for screening for esophageal SCC in patients with head and neck cancers.