Is osteopontin expression correlated with differentiation and good prognosis in medullary thyroid carcinoma?
The expression of OPN in normal C-cells and C-cell hyperplasia suggests that OPN is a differentiation marker of C-cells, rather than a marker of biological aggressiveness in this setting. At variance with other cancers, OPN expression is associated with good prognostic features in MTC.
These small differences in reporting rates would not warrant regulatory action and support the usual assumption of similar reporting for similar drugs.