Physician's preference-based instrumental variable analysis: is it valid and useful in a moderate-sized study?
The lesser statistical precision limits the usefulness of instrumental variable analysis in a study that might be of sufficient size for conventional analyses, even if a strong and plausible instrument is available.
We have determined the genetic landscape of human α- and β-cells based on chromatin accessibility and transcript levels, which allowed for detection of novel α- and β-cell signature genes not previously known to be expressed in islets. Using fine-mapping of open chromatin, we have identified thousands of potential cis-regulatory elements that operate in an endocrine cell type-specific fashion.