Is chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate associated with increased mortality and loss of ATP in rats after myocardial infarction?
Rats with an 87% predepletion of myocardial PCr content cannot survive an acute MI. Chronically infarcted hearts subjected to additional PCr depletion cannot maintain ATP homeostasis.
High BMI and ASA IV are independent risk factors for block failure in ambulatory surgery patients.