Does lubiprostone increase spontaneous bowel movement frequency and quality of life in patients with chronic idiopathic constipation?
In phase 3 studies in Japan, lubiprostone increased the weekly average number of SBMs and increased the quality of life of patients with CIC. Clinical Trial Notification of the Japanese Regulatory Authorities: 20-3296 and 20-3300.
We conclude that Usa1 has two important roles in ERAD substrate ubiquitylation.