Does toxicogenomic analysis of Caenorhabditis elegans reveal novel genes and pathways involved in the resistance to cadmium toxicity?
Because many C. elegans genes and signal transduction pathways are evolutionarily conserved, these results may contribute to the understanding of the functional roles of various genes in cadmium toxicity in higher organisms.
These results suggest that the α(1A)-AR subtype activates C-fiber afferents, and that consequently α(1A)-blockade can improve bladder storage function.