Does selective cyclo-oxygenase-2 inhibition with parecoxib acutely impair endothelium-dependent vasodilatation in patients with essential hypertension?
COX-2 inhibition with the prodrug, parecoxib, diminishes the acetylcholine-induced vasodilatation in the forearm circulation of patients with essential hypertension. It is speculated that the production of vasodilator prostaglandins may be important in pathological states with endothelial dysfunction, at least in patients with essential hypertension.
Lesch's typology may not be related with the genotype of alcoholics - at least in terms of genes with an established role in the development of dependency.