Do enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide?
Our results show that the activation of glial cells in the context of neuroinflammation kills enteric neurons. Mediators of inflammation that include ATP and NO activate neurotoxic pathways that converge on glial Cx43 hemichannels. The glial response to inflammatory mediators might contribute to the development of motility disorders.
Diagnostic terminology does not appear to have a potent influence on symptom expectation and injury perceptions in contact-sport players.