Does long-term phlebotomy with low-iron diet therapy lower risk of development of hepatocellular carcinoma from chronic hepatitis C?
Long-term iron depletion for CHC patients is a promising modality for lowering the risk of progression to HCC.
Reduction in low molecular weight hemoglobin concentrations to less than 1% is insufficient to abrogate the vasoconstrictor effects of HBOC infusion in healthy awake sheep or in mice with reduced vascular nitric oxide levels associated with endothelial dysfunction. These findings suggest that testing HBOCs in animals with endothelial dysfunction can provide a more sensitive indication of their potential vasoconstrictor effects.