Does platelet GPIIb/IIIa receptor blockade reduce infarct size in a canine model of ischemia-reperfusion?
Diminished infarct size with MK-0852 treatment suggests an additional mechanism of benefit for GPIIb/IIIa blockers beyond stabilization of a "culprit" acute coronary lesion. This cytoprotective effect was unrelated to preservation of coronary vasoreactivity (assessed by reactive hyperemia), restoration of blood flow across the myocardium or acute improvement in contractility.
Propranolol effectively blunts the stress response due to CO2 pneumoperitoneum during laparoscopic cholecystectomy.