Is promoter hypermethylation of the p16 gene and loss of its protein expression correlated with tumor progression in extrahepatic bile duct carcinomas?
Promoter hypermethylation is an important mechanism in the inactivation of the p16 gene in EBD carcinogenesis. Furthermore, the loss of p16 expression, with or without p16 gene promoter hypermethylation, is closely related to the tumor progression in EBD carcinomas.
Posterior displacement was larger in the lateral compartment at both flexion angles with manual posterior stress. As the knees flexed from 90 degrees to 135 degrees , posterior displacement became larger in the lateral compartment.