Detection and treatment of subclinical hypothyroidism in patients with irritable bowel syndrome. Does it modify the use of health resources?
The detection and treatment of subclinical hypothyroidism do not modify the utilization of healthcare resources in IBS.
Our data suggest that S. cerevisiae HMO1 protects linker DNA from nuclease digestion, a property also characteristic of mammalian linker histone H1. Notably, association with HMO1 creates a less dynamic chromatin environment that depends on its lysine-rich domain. That HMO1 has linker histone function has implications for investigations of chromatin structure and function as well as for evolution of proteins with roles in chromatin compaction.