Are increased susceptibility of tumorigenicity and decreased anti-tumor effect of DC vaccination in aged mice potentially associated with increased number of NK1.1+CD3+ NKT cells?
Based on these data, we conclude that NK1.1+CD3+ NKT cells from aged mice mediate immunosuppression, and further suggest that increased number of NK1.1+CD3+ NKT cells in aged mice might, among others, diminish their immune function by mediation of immunosuppression.
The stratum corneum barrier function is less effective in chronically UVB-exposed skin than in normal non-exposed skin, but more effective than in tape stripped skin. A higher penetration rate of ALA into (pre)cancerous lesions may be (partly) responsible for the greater accumulation of PpIX in such lesions.