Is a bacteria-specific 2 [ 4Fe-4S ] ferredoxin essential in Pseudomonas aeruginosa?
The gene of the very low potential 2[4Fe-4S] ferredoxin displays characteristics of a housekeeping gene, and it belongs to the minority of genes that are essential in Pseudomonas aeruginosa. These data identify a new potential antimicrobial target in this and other pathogenic Proteobacteria.
Although depression is more common among various subgroups, our data show that the investigation of each high prevalence subgroup would detect only a minority of all cases in the total population. It is not possible to rely on active case finding in high prevalence subgroups for a high detection rate of depression in a practice population.