Do crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage?
The functional Aa-RNase III dimer is formed via mainly hydrophobic interactions, including a "ball-and-socket" junction that ensures accurate alignment of the two monomers. The fold of the polypeptide chain and its dimerization create a valley with two compound active centers at each end of the valley. The valley can accommodate a dsRNA substrate. Mn(2+) binding has significant impact on crystal packing, intermolecular interactions, thermal stability, and the formation of two RNA-cutting sites within each compound active center.
Against expectations, hypomania scores increased with the duration of the romantic relationship, suggesting that culture-related issues might shape the way romantic love may be experienced.