Is lINE-1 hypomethylation in noncancerous esophageal mucosae associated with smoking history?
A history of tobacco use was significantly associated with LINE-1 hypomethylation in noncancerous esophageal mucosae of ESCC patients. These results support the potential of LINE-1 methylation level as an indicator of epigenetic field for ESCC cancerization, particularly when caused by tobacco smoking.
PF joint OA was highly prevalent, more so than TF joint OA, and even in individuals ages<50 years. Further research is needed to elucidate the cause and effect relationship between chronic PF pain and PF joint OA.