Does calcitonin gene-related peptide inhibit interleukin-1beta-induced interleukin-8 secretion in human type II alveolar epithelial cells?
These data imply that AEII cell-derived CGRP suppress IL-1beta-induced IL-8 secretion in an autocrine/paracrine mode. Further investigation showed that CGRP attenuated IL-1beta-aroused ROS formation, which is an early indication of pro-inflammatory factor signaling.
Almost half of patients with stable CAD have profound bone marrow iron depletion that can be accurately assessed non-invasively using serum soluble transferrin receptor.