Does pGF2α-F-prostanoid receptor signalling via ADAMTS1 modulate epithelial cell invasion and endothelial cell function in endometrial cancer?
These data demonstrate elevated ADAMTS1 expression in endometrial adenocarcinoma. Furthermore we have highlighted a mechanism whereby FP receptor signalling regulates epithelial cell invasion and endothelial cell function via the PGF2α-FP receptor mediated induction of ADAMTS1.
Variable implementation of MCI diagnostic criteria may significantly complicate the homogeneity of this condition.