Is immune response to Bordetella pertussis associated with season and undernutrition in Senegalese children?
These results are consistent with the hypothesis that environmental and nutritional factors modulate children's response to pertussis following natural infection or vaccination.
Patients in conventional cardiovascular trials, not using consecutive screening are selected and not representative of the disease under investigation. They are younger, more often male, and have lower risk. This makes such trials less reliable and useful. It prolongs the length of a trial study and makes it more expensive. Consecutive screening and enrollment are feasible and offer a detailed description of the patient selection The consecutive principles contribute to representative patient samples and should be mandatory in future clinical trials.