Are thin < or = 1 mm level III and IV melanomas higher risk lesions for regional failure and warrant sentinel lymph node biopsy?
Thin level III and IV melanomas are at increased risk for late recurrence when compared with all thin melanomas. Because there is effective adjuvant therapy with alpha interferon for patients with stage III melanoma to treat regional and systemic disease, and because sentinel lymph node biopsy (SLNB) offers minimal morbidity, we suggest using SLNB to accurately stage and treat all patients with thin melanoma that are high Clark levels that are at increased risk for metastases.
The prevalence of use of HRT and characteristics of users among Portuguese women living in Porto and entering menopause in the last 20 years have not changed substantially.