Does short-term overfeeding induce insulin resistance in weight-stable patients after bariatric surgery?
This study shows that overfeeding in a group of weight-stable, former morbidly obese subjects 3 years after bariatric surgery results in decreased insulin sensitivity. The mechanisms behind decreased insulin sensitivity induced by overfeeding are poorly understood, but the present results reveal that a unique human model is available to study these mechanisms, leading to a better understanding of the pathophysiology of IR.
These data clearly suggest that there is no difference between the amount of particulate debris generated in OPCAB cases versus CPB cases. In OPCAB cases where an anastomosis device was used without a partial clamp, particulate debris may be reduced but not eliminated. These findings may demonstrate the importance of aortic manipulation, particularly clamping, as a source of particulate material in cardiac surgery. However, more study needs to be done to confirm these findings with a larger number of patients.