Are bone marrow lesions from osteoarthritis knees characterized by sclerotic bone that is less well mineralized?
Our preliminary data localize specific changes in bone mineralization, remodeling and defects within BMLs features that are adjacent to the subchondral plate. These BMLs appear to be sclerotic compared with unaffected regions from the same individual based on the increased bone volume fraction and increased trabecular thickness. The mineral density in these lesions, however, is reduced and may render this area to be mechanically compromised, and thus susceptible to attrition.
To accurately compare trauma center performance and injury severity, the inclusion of autopsy data is critically important. Present state law does not permit sharing of this information with the trauma centers. When comparing mortality rates of New York State trauma centers, data must be carefully interpreted.