Is cellular resistance to mitomycin C associated with overexpression of MDR-1 in a urothelial cancer cell line ( MGH-U1 )?
Urothelial cancer cell resistance to mitomycin C is associated with cross-resistance to epirubicin and overexpression of MDR-1, suggesting that mitomycin C falls within the MDR category. Clinical application of this methodology may allow patients to be identified who are unlikely to benefit from intravesical chemotherapy.
Methacholine challenge is an insufficient screening test to detect bronchial hyper-responsiveness in a symptomatic military population. In military recruits, EIB is associated with training failure.