Does isoflurane enhance both fast and slow synaptic inhibition in the hippocampus at amnestic concentrations?
Isoflurane enhances both types of phasic GABA A receptor-mediated inhibition to similar degrees at amnesic concentrations. This pattern differs from etomidate, which at low concentrations selectively enhances slow inhibition. These effects of isoflurane are sufficiently large that they may contribute substantially to its suppression of hippocampal learning and memory.
The activation of the p53 pathway is involved in SBHA-induced apoptosis in MCF-7 cells.