Clopidogrel and proton pump inhibitor (PPI) interaction: separate intake and a non-omeprazole PPI the solution?
The clopidogrel-PPI interaction does not seem to be a PPI class effect. Rabeprazole did not affect the clopidogrel effect in a subject with a clear omeprazole-clopidogrel interaction. The separate intake of PPI and clopidogrel may not be sufficient to prevent their interaction.
Iatrogenic and non-iatrogenic arterial injuries show different characteristics concerning epidemiology and management. Injury of main adjacent structures remains a major risk factor for primary as well as secondary amputation. Endovascular treatment when indicated remains a therapeutic choice with optimal results.