Does a non-erythropoietic peptide derivative of erythropoietin decrease susceptibility to diet-induced insulin resistance in mice?
Chronic treatment of mice with an EPO derivative, devoid of haematopoietic effects, improved metabolic abnormalities induced by a high-fat high-sucrose diet, by affecting several levels of the insulin signalling and inflammatory cascades within skeletal muscle, while enhancing mitochondrial biogenesis.
The study did not show that the C242T polymorphism of the CYBA gene is a risk factor of ischaemic stroke in children.