Do obese subjects have significantly higher serum prooxidantantioxidant balance values compared to normal-weight subjects?
The high levels of PAB values in obese subjects without overt signs/symptoms of cardiovascular disease may be related to a heightened state of oxidative stress associated with obesity.
Our results suggest that, in response to multiple extracellular signals, phosphorylation of Ste11p by Ste20p removes an amino-terminal inhibitory domain, leading to activation of the Ste11 protein kinase. This mechanism may serve as a paradigm for the activation of mammalian MEKKs.