Does a pre-emptive multimodal pathway featuring peripheral nerve block improve perioperative outcomes after major orthopedic surgery?
Patients undergoing THA or TKA using a comprehensive, pre-emptive, multimodal analgesic regimen emphasizing peripheral nerve block may have significantly improved perioperative outcomes, and fewer adverse events, when compared with patients receiving traditional intravenous opioids during the initial postoperative period. Improved perioperative outcomes include a shortened hospital length of stay, and a significant reduction in postoperative urinary retention and ileus formation.
Our results indicate that blocking the Rho-kinase pathway during cold preservation may lead to a better graft function upon reperfusion.