Are dNA sequence variants in PPARGC1A , a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex , associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways?
Ligands and co-activators of the ω-3 LCPUFA sensing PPAR-RXR axis may influence retinal angiogenesis in NV AMD via the complement and VEGF signaling systems. We have linked the co-activator of a lipid-sensing transcription factor (PPARG co-activator 1 alpha, PPARGC1A) to age-related macular degeneration (AMD) and AMD-associated genes.
These findings suggest that economics and geography are more likely to influence a woman's initial choice of provider than medical and obstetric risk.