Are nerve growth factor and artemin paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma?
The neurotrophic effects of PCa extend into the peritumoral "normal" pancreatic areas without neuro-cancer interactions. The neurotrophic characteristics of PCa can be mimicked by in vitro analyses and reveal NGF and Artemin as potential key players in the generation of pancreatic neuropathy in PCa.
D1R might be applied in improving both HSC expansion ex vivo and HSC engraftment in vivo in transplantation.