Is nonocclusion and early reopening of the great saphenous vein after endovenous laser treatment fluence dependent?
ELT failure seems to be related to the administration of low laser fluences.
The two structures reported here provide a more complete description of the phosphoinositide binding region compared to the previously reported 2.6 A crystal structure of human PI3K-C2alpha PX where this region was highly disordered. The structures enabled us to further analyse PI specificity and to postulate that the observed conformational change could be related to ligand-binding.