Does nF-kappaB p50 facilitate neutrophil accumulation during LPS-induced pulmonary inflammation?
p50 makes essential contributions to neutrophil accumulation elicited by LPS in the lungs. This p50-dependent pathway for neutrophil accumulation can be overcome by bacterial products other than LPS and does not require IL-6.
Our findings suggest that serum TGF-β1 level increases during postmenopause and declines in old age. Sclerostin production is inhibited by TGF-β1 during early postmenopause.