Is sensation of abdominal pain induced by peritoneal carcinomatosis accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice?
Both the up-regulation of substance P and down-regulation of μ-opioid receptor seen in the dorsal root ganglia may be, at least in part, responsible for the abdominal pain-like state associated with peritoneal carcinomatosis.
The ACE D allele has a significant effect on the in vivo degradation of bradykinin in humans. The ratio of BK1-5:bradykinin may serve as a marker for tissue ACE activity.