Do very-long-chain fatty acids activate lysosomal hydrolases in neonatal human skin tissue?
Experimen tal dysfunction of peroxisomes mimicked by elevated VLCFA or ATZ-mediated catalase inhibition significantly increased the activities of lysosomal hydrolases in human dermal tissue, suggesting that activation of the lysosomal system could be one of the factors responsible for cellular damage during pathogenesis of peroxisomal diseases.
Two randomized clinical trials are scheduled for completion within the next year, and they should offer answers about mechanisms of myopia control. Treatments for myopia are moving beyond questions of safety and efficacy and on to reductions of complications and refinement of vision to produce super vision. At least one eye drop, pirenzepine, is being investigated for myopia control and may show promise for prevention of myopia in the future.