Is epidermal growth factor-stimulated extravillous cytotrophoblast motility mediated by the activation of PI3-K , Akt and both p38 and p42/44 mitogen-activated protein kinases?
We demonstrate a role for PI3-K, p42/44 MAPK and p38 MAPK in the stimulation of CTB cell motility by EGF, however activation of beta-catenin alone was insufficient to stimulate cell motility.
This study showed that tumor sterilization is significantly correlated with overall treatment time and probably with cumulative dose delivered to the HR-CTV. These results emphasize the attention that must be given to treatment organization and dosimetry optimization.