Is human Scc4 required for cohesin binding to chromatin , sister-chromatid cohesion , and mitotic progression?
Our data indicate that human Scc4 is required for the association of cohesin with chromatin, which is a prerequisite for the establishment of sister-chromatid cohesion and for chromosome biorientation in mitosis. The proteinaceous machinery that is required for loading of cohesin onto chromatin is therefore conserved from yeast to humans. The finding that Caenorhabditis elegans MAU-2 is an ortholog of Scc4 further supports the notion that the Scc2-Scc4 complex is required for developmental processes in metazoans.
Automated ablation lesion annotation provides real-time feedback of RF ablation that may improve effective energy delivery.