Does altering PI3K-Akt signalling in zebrafish embryos affect PTEN phosphorylation and gastrulation?
These results suggest that Ptena454 regulation is correlated to changes in phospho-Akt levels. We propose a model in which homoeostasis in rapidly dividing and migrating embryonic cells depends on a counterbalance between pro-survival signalling employing CK2 and GSK-3 and the pro-apoptotic activity of Ptena454.
We conclude that the FTO gene contributes to determine weight changes in children with celiac disease on GFD.