Is neointimal hyperplasia on a cell-seeded polytetrafluoroethylene graft promoted by transfer of tissue plasminogen activator gene and inhibited by transfer of nitric oxide synthase gene?
Engineered tPA expression in seeded SMCs causes significantly more neointimal hyperplasia, despite the favorable inhibition of luminal thrombus. eNOS expression in the seeded cells inhibits neointimal hyperplasia.
Among de novo renal cases, the new once-daily formulation of tacrolimus offered a similar short-term efficacy profile as the twice-daily tacrolimus. But it was necessary to use up to a 50% higher dose of Advagraf than Prograf to achieve similar trough levels during the first 6 months.