Does two weeks of pretreatment with escitalopram facilitate extinction learning in healthy individuals?
Escitalopram administered for 14 days prior to a fear conditioning paradigm did not influence acquisition of a conditioned fear response but did facilitate extinction learning. Impairments in extinction learning have been identified as a key component of posttraumatic stress disorder; our preliminary findings suggest that additional experimental and clinical studies assessing the efficacy of selective serotonin reuptake inhibitors for posttraumatic stress disorder prevention are warranted.
Perfusion deficits are found in TIA patients using whole brain CTP and associated with components of the ABCD2 score.