Are seasonal modifications in blood pressure mainly related to interdialytic body weight gain in dialysis patients?
Our results establish a strong link between blood pressure variations and interdialytic body weight gain, showing the important participation of volume state in modulating blood pressure in this group of patients.
We demonstrate that EPO, administered at the point of reperfusion, reduced infarct size in an isolated perfused rat heart, in an ERK and PI3K dependent manner; in addition the mechanism was also confirmed in a whole animal model of ischaemia-reperfusion. These results suggest that EPO may be able to directly protect the myocardium against lethal reperfusion-induced injury and so offer the myocardium an additional clinical advantage over and above its ability to improve the oxygen carrying capacity of the blood.