Is osteocalcin related to enhanced insulin secretion in gestational diabetes mellitus?
In GDM osteocalcin was higher and thus less restrained than in women with NGT during pregnancy and furthermore correlated with insulin secretion parameters. Therefore, it could be hypothesized that osteocalcin can enhance insulin secretion in insulin-resistant states; alternatively an effect of hyperinsulinemia on osteocalcin secretion cannot be excluded.
This is the first evidence that CB(2) and TRPV(1) receptors cooperate to modulate MDR1 expression.