Does [ Metformin inhibit THP-1 macrophage-derived foam cell formation induced by lipopolysaccharide ]?
Met could inhibit THP-1-derived foam cell formation induced by LPS, reduce intracellular lipid accumulation, and down-regulate the expression of ADRP.
In this small cohort of patients with early septic shock, short-term IV infusion of NAC was well-tolerated, improved respiratory function, and shortened ICU stay in survivors. The attenuated production of IL-8, a potential mediator of septic lung injury, may have contributed to the lung-protective effects of NAC.