Is homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells mediated by PI3 Kinase and p38 MAPK?
The data suggest that Hcy participates in inflammatory cytokines production by glomerular MC and that Hcy-induced MIP-2 mediates leukocyte adhesion to MC.
Severe CSA in CHF patients is associated with elevated levels of CRP, a systemic marker of inflammation and cardiovascular risk. This might explain in part the negative prognostic impact of CSA in these patients.