Does folic acid inhibit homocysteine-induced proliferation of human arterial smooth muscle cells?
A possible role of homocysteine in the formation of atherosclerotic lesions is through a direct proliferative effect on VSMCs in a dose-dependent fashion. Folic acid intake at levels available in dietary supplements may prove protective in hyperhomocysteinemia-induced atherosclerosis. Vitamins B(6) and B(12) alone do not appear to exhibit a substantial inhibitory effect in the setting of elevated homocysteine levels.
These results indicate that combination of t-AUCB and quercetin may be a potential approach to treating glioblastoma.