Does simvastatin reduce MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation?
These results demonstrate that simvastatin, by inhibiting Rac1 activity, reduces MMP1 expression and collagen degradation in human smooth muscle cells.
Our experiments support a dual function of PSTI-I: monitoring protein in the gut due to its 'moderate' affinity for trypsin and a protective role in the pancreas.