Do trauma-hemorrhage delays wound healing potentially by increasing pro-inflammatory cytokines at the wound site?
Because increased levels of pro-inflammatory cytokines and decreased amounts of TGF-beta have been reported to impair the process of wound healing, the increased release of IL-1 beta and IL-6 and the decreased release of TGF-beta after hemorrhage might contribute to the decreased collagen production in those animals. Thus, attempts to locally change the ratio of those cytokines in trauma victims might be useful for improving wound healing in those patients.
: Prophylactic fixation with a cephalomedullary nail was not found to be cost-effective for the average older woman who sustained a hip fracture. However, it may be appropriate for select patient populations. The study supports the need for basic science and clinical trials investigating the effectiveness of prophylactic fixation for patient populations at higher lifetime risk for contralateral hip fracture.