Does ebola virus glycoprotein demonstrate differential cellular localization in infected cell types of nonhuman primates and guinea pigs?
Ebola virus GP appears to selectively accumulate in many cell types infected in vivo, but not in macrophages and monocytes. This finding suggests that many cell types may have a GP-processing pathway that differs from the pathway described by previous in vitro studies. Differential cellular localization of GP could be relevant to the pathogenesis of Ebola hemorrhagic fever.
In this population the elderly had more non-significant hemorrhagic complications but their higher in-hospital mortality was not associated with the adoption of an invasive approach. We therefore suggest that age by itself does not limit the adoption of a systematic invasive strategy.