Does streptozotocin-induced diabetes increase amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-κB pathway?
Our study suggests that there is a close linkage of DM and cerebral amyloidosis in the pathogenesis of AD.
These results suggest a direct role for aberrant methylation of the TMS1 gene in the progression of breast and gastric cancer involving down-regulation of the proapoptotic TMS1 gene.