Is increased use of regional radiotherapy associated with improved outcome in a population-based cohort of women with breast cancer with 1-3 positive nodes?
Post-BCS LRRT use in British Columbia increased almost threefold in patients with 1-3N+ after 1997. Adjuvant LRRT was associated with improved LRC, but not with improved BCSS compared to breast RT alone.
Our data suggest that Hsp60 release is the result of an active secretion mechanism and, since extracellular release of the chaperone was demonstrated in all tumor cell lines investigated, our observations most likely reflect a general physiological phenomenon, occurring in many tumors.