Do high miR-196a levels promote the oncogenic phenotype of colorectal cancer cells?
miR-196a exerts a pro-oncogenic influence in colorectal cancer.
Our results thus demonstrate a pivotal role of CYP2E1 in cisplatin-induced nephrotoxicity and apoptosis. We postulate that the interaction of cisplatin with CYP2E1 results in the generation of ROM that causes renal injury and initiates apoptosis.