Does a variant of Smurf2 protect mice against colitis-associated colon cancer by inducing transforming growth factor β signaling?
T cell-specific ΔE2Smurf2 degrades wild-type Smurf2 and controls intestinal tumor growth in mice by up-regulating TGF-β receptor type II, reducing proliferation and production of proinflammatory cytokines.
A reduced kidney function, even mildly, is significantly associated with CAD severity, independently of other traditional CAD risk factors.