Does helicobacter pylori with high thioredoxin-1 expression promote stomach carcinogenesis in Mongolian gerbils?
High Trx1 expression in H. pylori promoted stomach carcinogenesis. More studies are needed to confirm this finding.
Based on the co-location of mutations from different organisms and their proximity to the enzyme active site, we have extrapolated observed mutations from one species to homologous positions in other organisms, as a predictive approach for detecting likely alpha-mannosidosis. Besides predicting new disease mutations, this approach also provides a way for detecting mutation hotspots in the gene, where novel mutations could be implicated in disease. The current study has identified five mutational hot-spot regions along the MAN2B1 gene. Structural mapping can thus provide a rational approach for predicting the phenotype of a disease, based on observed genotypic variations.