Does adenovirus-mediated overexpression of glutathione-s-transferase mitigate transplant arteriosclerosis in rabbit carotid allografts?
Our data indicate that hGSTA4-4 overexpression protects the integrity of vessel wall from oxidative injury, and attenuates transplant arteriosclerosis.
Patients with C4d deposition had an inferior graft survival, especially with diffused C4d deposition, and later experienced acute rejection. C4d deposition was an independent risk factor for graft survival.