Do senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion?
Senescent CAFs from GU-OSCC promote a more aggressive oral cancer phenotype by production of active MMP-2, disruption of epithelial adhesion and induction of keratinocyte invasion.
Systematic invitations for consultation and spirometry in general practice as COPD prevention has proven to be difficult. Various models should be assessed before large scale interventions are implemented.