Is epigenetic inactivation of transforming growth factor-β1 target gene HEYL , a novel tumor suppressor , involved in the P53-induced apoptotic pathway in hepatocellular carcinoma?
HEYL is frequently downregulated by promoter methylation in HCC. HEYL may be a tumor suppressor of liver carcinogenesis through upregulation of P53 gene expression and activation of P53-mediated apoptosis.
Propolis showed a significant protective effect on ileal mucosa and reduced bacterial translocation in the experimental obstructive jaundice model. Further studies should be carried out to explain the mechanisms of these effects.