Does conditional knockout of macrophage PPARgamma increase atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice?
Thus, macrophage PPARgamma deficiency increases atherosclerosis under conditions of mild and severe hypercholesterolemia, indicating an antiatherogenic role for PPARgamma, which may be caused, at least in part, by modulation of CCR2 expression and monocyte recruitment.
From the presented data it may be concluded that 5-year survival of implant-supported single crowns is high, although biologic and mechanical complications are anticipated.