Does abnormal methylation of the sex-determining region Y-box 17 ( SOX17 ) promoter predict poor prognosis in myelodysplastic syndrome?
These findings suggest that the hypermethylation of SOX17 promoter may be one of the early events in the development of MDS and predicts poor prognosis.
Overall, modular heterogeneity provides a framework with which to dissect cancer heterogeneity and better understand its underpinnings, thereby ultimately advancing our knowledge towards a more effective personalized cancer therapy.