Is pediatric onset Crohn 's colitis characterized by genotype-dependent age-related susceptibility?
In early-onset pediatric CD, children with NOD2/CARD15 mutations demonstrate more ileocolitis and less isolated ileitis. Young children without NOD2/CARD15 mutations have an isolated colonic disease distribution, suggesting that this phenotype is associated with genes that lead to a specific phenotype of early-onset disease.
The sole use of parental occupation or area-based measures to monitor widening participation programmes requires caution given the proportion of applicants who do not provide this information and the age and ethnic group differences noted.