Are [ Continuous Svo2 measurements and co-oximetry interchangeable immediately after cardiopulmonary bypass ]?
Our results demonstrate that, in the immediate aftermath of cardiopulmonary bypass, the continuous measurement of SvO(2) and the co-oxymetry determination of mixed blood is not inter-changeable. Other studies will be necessary to confirm these results and enable us to understand the pathophysiological phenomena accounting for the lack of agreement between the two methods.
Cortactin is a direct binding partner and novel substrate of ACK1. Tyrosine phosphorylation of cortactin by ACK1 creates an additional means to amplify Arp2/3 dynamics through N-WASp activation, potentially contributing to the overall necessary tensile and/or propulsive forces utilized during EGFR endocytic internalization and trafficking involved in receptor degradation.