Does the endothelin-1 receptor antagonist BQ-123 reduce infarct size in a canine model of coronary occlusion and reperfusion?
These data indicate that endothelin-1 release during ischaemia may be involved in the pathogenesis of myocardial ischaemia and infarction.
HIV infection in the elderly is generally diagnosed in an advance stage, but antiretroviral therapy prolongs survival. Zidovudine should be reserve as a second line drug because its frequent haematological toxicity.