Is heart rate associated with increased risk of major cardiovascular events , cardiovascular and all-cause death in patients with stable chronic cardiovascular disease : an analysis of ONTARGET/TRANSCEND?
This large study examined and quantitated associations between heart rate and CV events in a contemporary medically optimized population with stable CV disease. Resting and, in particular, in-trial average heart rate are independently associated with significant increases in CV events and all-cause death.
Mutant LXR-α protein in CHD subjects is degraded by BARD1/BRCA1 complex and Vitamin D3 can rescue and restore its function.