Does substance P induce inflammatory responses involving NF-κB in genetically diabetic mice skin fibroblasts co-cultured with macrophages?
The promoting effects of SP on diabetic wound healing was dependent on enhanced inflammatory responses, especially the activation of NF-κB. This study provided evidence for the potential usage of SP in accelerating diabetic wound healing.
Recombinant human BMP-2 appears to be able to accelerate bone formation of mandibular distraction osteogenesis in rabbits.