Is interleukin-6 an important in vivo inhibitor of intestinal epithelial cell death in mice?
IL-6 inhibited both constitutive and induced enterocyte cell death in vivo. Loss of IL-6 in mice resulted in increased activation of pro-apoptotic and necrotic pathways in enterocytes after injury. Therapies that augment IL-6 or its signalling pathways may help manage intestinal disorders associated with increased apoptosis, necrosis and gut injury.
Long term (5 years) follow up showed that transnasal endoscopic marsupilization of Thornwaldt's cyst using micodebrider is a safe and effective maneuver with no cyst recurrence, eustachian tube affection or post-operative complications.