Does respiratory syncytial virus infection provoke airway remodelling in allergen-exposed mice in absence of prior allergen sensitization?
Our data show for the first time that RSV infection can prime the lung of mice that are not previously systemically sensitized, to develop airway remodelling in response to allergen upon sole exposure via the airways. Moreover, our results implicate RSV-induced FGF-2 in the remodelling process in vivo.
Our findings underscore the need for an increased awareness amongst health and social care professionals of the extent and nature of the problem, as well as intervention options. A co-ordinated approach to detection and intervention is discussed and recommendations are made for future research in this area.