Growth factor profiles of human gliomas. Do non-tumour cells contribute to tumour growth in glioma?
Multiple growth factors appear to be involved in astrocytic tumours, with frequent autocrine and paracrine loops. Expression of these molecules seems to increase with increasing grade. The results argue for a contribution of non-tumour cells to the growth of a tumour.
These results lead us to suggest that, although alpha-melanotropin stimulates progesterone release in pre-ovulatory GC, this effect is blocked by the presence of interleukin-1beta or TNF-alpha.