Is coronary artery disease associated with higher epicardial retinol-binding protein 4 ( RBP4 ) and lower glucose transporter ( GLUT ) 4 levels in epicardial and subcutaneous adipose tissue?
Retinol-binding protein 4 levels behave differently in EAT and SAT with respect to CAD. However, both adipose tissues have lower GLUT4 levels in patients with CAD. These findings suggest a differential regulation of RBP4 production in EAT and SAT that may be influenced by local factors.
These data indicate that OPG may be involved in tumorigenesis and the progression of colon cancer.