Does conversion of nanoscale topographical information of cluster-assembled zirconia surfaces into mechanotransductive events promote neuronal differentiation?
Our work provides a deep insight into the molecular mechanotransductive mechanisms that realize the conversion of the nanoscale topographical information of SCBD-fabricated surfaces into cellular responses, in this case neuronal differentiation. The results lay a profound cell biological foundation indicating the strong potential of these surfaces in promoting neuronal differentiation events which could be exploited for the development of prospective research and/or biomedical applications. These applications could be e.g. tools to study mechanotransductive processes, improved neural interfaces and circuits, or cell culture devices supporting neurogenic processes.
Lateral pelvic lymph node metastasis is an important prognostic factor for low rectal cancer.