Is human sterile alpha motif domain 9 , a novel gene identified as down-regulated in aggressive fibromatosis , absent in the mouse?
SAMD9 and SAMD9L are a novel family of genes, which play a role regulating cell proliferation and suppressing the neoplastic phenotype. This is the first report as far as we know about a human gene that exists in rat, but is lost in mouse, due to a mouse specific rearrangement, resulting in the loss of the SAMD9 gene.
These results indicate that trauma patients present a dysregulation of the innate immune system that persists during the first 14 days after hospital admission.