Are in enterovirus 71 encephalitis with cardio-respiratory compromise , elevated interleukin 1β , interleukin 1 receptor antagonist , and granulocyte colony-stimulating factor levels markers of poor prognosis?
Given that IL-1β has a negative inotropic action on the heart, and that both its natural antagonist, IL-1Ra, and G-CSF are being assessed as treatments for acute cardiac impairment, the findings suggest we have identified functional markers of EV71-related cardiac dysfunction and potential treatment options.
In this study we observed that, in locally advanced cervical patients showing complete clinical response to neo-adjuvant chemoradiation, the cone biopsy feasibility was almost 75%, and that there is a complete pathological correspondence between cone and definitive pathology.