Does l-threo-dihydroxyphenylserine correct neurochemical abnormalities in a Menkes disease mouse model?
We conclude that (1) L-DOPS crosses the blood-brain barrier in mo-br mice and corrects brain neurochemical abnormalities, (2) norepinephrine deficiency is not the cause of neurodegeneration in mo-br mice, and (3) L-DOPS treatment may ameliorate noradrenergic hypofunction in Menkes disease.
Single-source 80 kV pancreatic phase scanning results in higher conspicuity of pancreatic adenocarcinoma and FOM and in significant dose reduction while maintaining acceptable image quality.