Does precoagulation minimize blood loss during standardized hepatic resection in an experimental model?
Precoagulation of liver tissue before transection is associated with less blood loss compared with ultrasonic dissection.
The observed promiscuous expression of Dll4 and the increase in cell proliferation, apoptosis and vascularization are events compatible with loss of the tip/stalk phenotype. Excessive (although very likely defective) decidual angiogenesis due to such vascular alterations is the most likely cause of subsequent interruption of embryo development and related pregnancy in Dll4 treated mice.