Does an intraductal human-in-mouse transplantation model mimic the subtypes of ductal carcinoma in situ?
The intraductal HIM transplantation model provides an invaluable tool that mimics human breast heterogeneity at the noninvasive stages and allows the study of the distinct molecular and cellular mechanisms of breast cancer progression.
These results identify ER-TR7 as an important component of LN structure in tolerance and a direct target for immune modulation.