Does the phosphorylation motif at serine 225 govern the localization and function of sphingosine kinase 1 in resistance arteries?
Translocation and precise subcellular positioning of Sk1 is essential for full Sk1 function; and two distinct S1P pools, proposed to be intra- and extracellular, contribute to the maintenance of vascular tone.
Information on FH was obtained through the proband.