Does nitric oxide from rat liver sinusoidal endothelial cells induce apoptosis in IFN gamma-sensitized CC531s colon carcinoma cells?
(i) LSECs induce apoptosis in IFNgamma-sensitized CC531s in vitro; (ii) LSECs express FasL; (iii) Fas on CC531s becomes active after IFNgamma-treatment; however, (iv) blocking the Fas/FasL pathway had no effect; (v) apoptosis was inhibited by NO-inhibitors; (vi) the immune system uses this IFNgamma-activated pathway to support LSECs in killing tumor cells.
The VEGF +936 T allele is associated with an increased risk of stage III-IV endometriosis in a Japanese population.