Is aMPK alpha1 activation required for stimulation of glucose uptake by twitch contraction , but not by H2O2 , in mouse skeletal muscle?
These results provide strong genetic evidence that alpha(1) AMPK, but not alpha(2) AMPK, Akt or AS160, is necessary for regulation of twitch-contraction stimulated glucose uptake. To our knowledge, this is the first report to show a major and essential role of alpha(1) AMPK in regulating a physiological endpoint in skeletal muscle. In contrast, AMPK is not essential for H(2)O(2)-stimulated muscle glucose uptake, as proposed by recent studies.
Although female patients with SPNP outnumbered male patients with SPNP, there were no gender-specific trends in expression of sex hormone receptor protein or clinicopathologic characteristics.