Does overexpression of activator of G-protein signaling 3 decrease the proliferation of esophageal squamous cell carcinoma?
This study shows that AGS3 is an important regulator of ESCC proliferation.
Our results are significant and clinically relevant as they provide the first biomarker of asbestos exposure and indicate that hyperacetylated HMGB1 is an accurate biomarker to differentiate malignant mesothelioma patients from individuals occupationally exposed to asbestos and unexposed controls. A trial to independently validate these findings will start soon. Clin Cancer Res; 22(12); 3087-96. ©2016 AACR.