Does nF-kappaB-induced oxidative stress contribute to mitochondrial and cardiac dysfunction in type II diabetes?
This study demonstrates that NF-kappaB blockade with PDTC mitigates oxidative stress and improves mitochondrial structural integrity directly, through down-regulation of increased oxygen-free radicals, thereby increasing ATP synthesis and thus restoring cardiac function in type II diabetes.
The results indicated that long-term steroid use within one year is associated with lower risk of colonic diverticulitis.