Does a multistage genetic association study identify breast cancer risk loci at 10q25 and 16q24?
Our data supports the association of two novel loci, at 10q25.3 and 16q23.1, with risk of breast cancer.
TNX interacts with VEGF-B and enhances the ability of VEGF-B to stimulate cell proliferation. This enhanced mitogenecity is caused by increased signals mediated by the VEGFR-1 receptor. This finding suggests a role for TNX in the regulation of the development of blood vessels such as vasculogenesis and angiogenesis.