Is c-terminal cleavage of DeltaNp63alpha associated with TSA-induced apoptosis in immortalized corneal epithelial cells?
DeltaNp63alpha is the dominant active isoform in corneal epithelial cell nuclei. Loss of DeltaNp63alpha occurs during apoptotic signaling by cleavage at the C terminus. The corresponding loss of p53 suggests that a significant relationship appears to exist between these two regulatory proteins.
IMP is afterload dependent in the normal LV. IMP is afterload dependent with acute and chronic LV dysfunction by influencing the isovolumic indices and LV ejection time in opposite directions. Further systematic evaluation of IMP is needed if this index is to be useful as a prognostic indicator.