Are the p110α and p110β isoforms of class I phosphatidylinositol 3-kinase involved in toll-like receptor 5 signaling in epithelial cells?
These data demonstrate that the p110α and β isoforms of class IA PI3K are both required for the proinflammatory response to flagellin.
Laparoscopic surgery for colon cancer is non-inferior to open surgery in terms of overall survival, and has been so since 2004. The majority expert opinion in the literature has considered these two techniques to be equivalent since 2002-2004. Laparoscopic surgery for rectal cancer has been increasingly accepted since 2006, but remains controversial. Knowledge translation efforts in this field appear to have paralleled the accumulation of clinical trial evidence.