Does gentamicin release from commercially-available gentamicin-loaded PMMA bone cement in a prosthesis-related interfacial gap model and their antibacterial efficacy?
Although marketed as the original gentamicin-loaded Palacos cement, orthopaedic surgeons should be aware that the successor cements do not appear to have the same release characteristics as the original one. Overall, high gentamicin concentrations were reached inside our prosthesis-related interfacial gap model. These concentrations may be expected to effectively decontaminate the prosthesis-related interfacial gap directly after implantation, provided that these bacteria are sensitive for gentamicin.
The association between aortic valve allograft structural deterioration and high titer human leukocyte class 2 antigen antibodies, a subset detected by ELISA adds further information about the link between HLA class 2 mismatch and structural deterioration. Further studies are needed to confirm the importance of class 2 antibodies on outcome, and to determine by which method these antibodies should be detected. Potential recipients with pre-existing antibodies of these specific types might be expected to sustain accelerated allograft damage.