Is the GABAB receptor agonist baclofen administered into the median and dorsal raphe nuclei rewarding as shown by intracranial self-administration and conditioned place preference in rats?
Baclofen injections into the midbrain raphe nuclei are rewarding. Baclofen was more readily self-administered into the MR than into the DR, while baclofen injections into the DR more readily induced conditioned place preference than those into the MR. These sites may be differentially involved in aspects of reward. These findings suggest that MR or DR neurons containing GABAB receptors are involved in tonic inhibitory control over reward processes.
Surgery at first recurrence of GBM improves outcome if complete resection of contrast-enhancing tumor is achieved.