Does cyclooxygenase-2 preserve flow-mediated remodelling in old obese Zucker rat mesenteric arteries?
COX2 preserved in part flow-mediated arterial remodelling in old obese rats. Nevertheless, this effect was not sufficient to keep endothelium-dependent relaxation to the level obtained in lean rats.
The double dose of analgesia results in lower maternal nighttime plasma estradiol concentrations and significantly less nocturnal contraction activity. These observations further confirm an association between increased maternal plasma estrogen concentrations and increased myometrial contractility in the nonhuman primate. In addition, they suggest that adjustment of the level of postoperative analgesia may be of importance in preventing premature labor after chuman intrauterine fetal surgery.