Do [ IL-18 and TNF-α promote the expression of IL-18Rβ in 3T3-L1 adipocytes and RAW264.7 macrophages ]?
IL-18Rβ could be up-regulated by IL-18 or TNF-α in 3T3-L1 adipocytes and RAW264.7 macrophages. IL-18 may be an important factor involved in the inflammation of adipose tissues in diabetes and obesity.
These studies suggest that cysteine proteinase inhibitors may limit tissue destruction in diseases such as rheumatoid arthritis.