Is abnormally extended ductal tissue into the aorta indicated by similar histopathology and shared apoptosis in patients with coarctation?
Abnormal extension of ductal tissue into the aorta in CoA patients was indicated by similar histology and shared apoptosis. SMC phenotypic modulation may be involved in the formation of CoA. Our results strongly support the hypothesis that abnormal extension of ductal tissue in the aorta plays a crucial role in the pathogenesis of CoA.
Hemolysis and leukocytosis were independent risk factors for an early decline in lung volumes in this pediatric SCD cohort.