Does overexpression of truncated I kappa B alpha potentiate TNF-alpha-induced apoptosis in mesangial cells?
Overexpression of I kappa B delta N potentiates TNF-alpha-induced apoptosis and augments caspase-8 and caspase-3 activity in rat MCs without changing Bcl-2 or Bax protein expression. These results suggest the potential usefulness of AdexI kappa B delta N to induce apoptosis in MCs under inflammatory conditions.
Early mortality has been substantially reduced in congenital heart defect patients, and corresponds with significantly improved long-term survival.