Is the helicase-like transcription factor a strong predictor of recurrence in hypopharyngeal but not in laryngeal squamous cell carcinomas?
Our results demonstrate, for the first time, that hypopharyngeal SCCs presenting high levels of HLTF have a worse prognosis. The quantitative determination of HLTF in hypopharyngeal SCCs was an independent prognostic marker alongside tumour node metastasis staging. HNSCCs expressed the truncated HLTF variant lacking the domains involved in DNA repair.
Transcatheter closure of complex ASDs is safe and effective under intracardiac echocardiographic guidance.