Is interferon-gamma involved in the intestinal manifestations of the acute murine semiallogenic graft-versus-host disease?
These findings indicate that IFN-gamma is not crucial for the development of crypt hyperplasia and villous atrophy in the murine semiallogenic GvHD.
Dronedarone reduced heart rate without affecting MAP or contractility, effects that differ from L-type calcium channel blockade. Dronedarone did not antagonize BAR stimulation, and its heart-rate lowering effects were eliminated by prior administration of ivabradine. Thus, dronedarone's bradycardic action is likely due to inhibition of If and not to blockade of either L-type calcium channels or BAR.