Does iFN-gamma increase efficiency of DNA vaccine in protecting ducks against infection?
DHBV preS/S DNA vaccine can protect ducks against DHBV infection, DuIFN-gamma gene as an immune adjuvant enhances its efficacy.
These data are critical for further study to more fully identify the determinants that mediate the evolution of biological transmission among flaviviruses. It also will be useful for studies that look to provide a comprehensive molecular definition of flavivirus-host cell interactions. And it will provide a cadre of information to design wet lab experiments to investigate the genetic changes that facilitate host switching, which may lead to new vertebrate pathogens or transmission pathways.