Is eIF5A2 a novel chemoresistance gene in breast cancer?
This study shows that eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells.
The results show that high-caloric saturated fat intake induced diabetes in hamsters, probably linked to delayed insulin secretion. The model was also associated with the development of a range of pathologies characteristic to human diabetes, including nephropathy and defects in vasculature. Thus, high-fat fed hamsters provide a new model that is likely to be useful in understanding the cellular and molecular mechanisms involved in the pathogenesis of diabetes.