Is increase in maternal adiposity and poor lipid profile associated with oxidative stress markers during pregnancy?
Normal pregnancy is associated with marked changes in lipid metabolism, prooxidant and antioxidant status. Dyslipidemia-associated oxidative stress was demonstrated with advancing gestational age. Appropriate preventive and compensatory measures should be practiced to minimize the effect of oxidative stress throughout pregnancy.
Our findings demonstrate an aberrant peripheral/spinal mechanism that induces and maintains thermal and to a greater degree tactile cutaneous hypersensitivity in the cuff model of neuropathic pain, and raise the prospect that altered peripheral/spinal nociceptive mechanisms in humans with peripheral neuropathy may have a pathologically relevant role in both inducing and sustaining neuropathic pain.