Does lysophosphatidic acid receptor 1 suppression sensitize rheumatoid fibroblast-like synoviocytes to tumor necrosis factor-induced apoptosis?
LPA(1) is an important receptor in RA FLS. Its suppression is accompanied by a global increase in the response to TNF that is ultimately dominated by sensitization to apoptosis.
Based on analyses of paired samples, the sDNA test detects nonmetastatic CRC and large adenomas with significantly greater levels of sensitivity than the SEPT9 test. These findings might be used to modify approaches for CRC prevention and early detection.