Do thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia?
We have described/discovered a complex, cell-type and tissue-specific expression pattern following the hypoxia/ischemia and reoxygenation. Particularly, Grx2 and Trx1 showed distinct changes during tissue recovery following hypoxia/ischemia and reoxygenation. Silencing of these proteins in SH-SY5Y cells subjected to hypoxia-reoxygenation confirmed that these proteins are required to maintain the normal neuronal phenotype.
The mean FRI obtained in this study is lower than the reported in constipated adults (2,8 min).We hypothesized that the higher FRI found in children with retentive fecal incontinence may be associated with retention behavior in cases of severe constipation and to higher anal resting pressure in patients with retentive incontinence.