Do novel genes dramatically alter regulatory network topology in amphioxus?
Domain rearrangements can potentially alter the topology of protein-protein interaction (and regulatory) networks. The extent of such arrangements in the innate immune network of amphioxus suggests that domain shuffling, which is an important mechanism in the evolution of multidomain proteins, has also shaped the development of immune systems.
AAA PWM is negligible and may not therefore be a potential tool to assess efficacy of endovascular aneurysm exclusion.