Does adenovirus-mediated p16 gene transfer change the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells?
These results suggest that in SKOV-3 cells, G1-arrest induced by p16-transduction prevents paclitaxel- and vindesine-induced cell death, and in OVCAR-5 cells, the other unknown mechanisms play a role of chemoresistance.
This study offers the first indication that MB may be associated with gait disturbances, independently of other coexisting markers of SVD.