Is electrical impedance tomography able to track changes in respiratory function in endotoxin-challenged rodents?
This study has demonstrated for the first time that eight-electrode EIT readily tracks the inflammatory response of lung tissue in a rodent model of ALI. EIT may thus provide a promising, non-invasive technique for monitoring the time-course of ALI in rodent models, and for testing novel pharmacological strategies to counter it.
The data suggest that mice respond to oxidative stress by increasing tissue vitamin E incorporation and cellular synthesis of glutathione in the lung when exposed to moderate levels (40%) of hyperoxia.