Does pirfenidone ameliorate concanavalin A-induced hepatitis in mice via modulation of reactive oxygen species/nuclear factor kappa B signalling pathways?
Pirfenidone hepatoprotective activity may be mediated through its antioxidant ability that suppresses NF-κB activation signalling pathways suggesting that PFD may be a new candidate for treatment of acute hepatitis.
GST pi occurs in normal cervical epithelium and in all stages of premalignant cervix, suggesting an important role in the detoxification process in all these stages. Its ubiquitous presence indicates, in contrast to the earlier reports, that the enzyme does not play a crucial role in the initiation of the carcinogenic cascade. However, the absence of this detoxificating enzyme in the nucleus of the majority of cervical carcinomas may indicate that xenobiotic compounds are not catabolized and may therefore exert their mutagenic activity, resulting in tumor progression.