Does inhibition of nuclear factor-kappa B activation attenuate hydrogen peroxide-induced cytotoxicity in human lens epithelial cells?
NF-kappaB signal pathway may be important in the development of H(2)O(2)-induced damage in HLE cells that is involved in cataractogenesis.
As all of the 5-HT1A compounds tested in this series share antagonistic activity in models of postsynaptic 5-HT1A receptor function, it is proposed that this action accounts for their effects on defence.