Does investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirm high degree of overlap?
A novel JIA susceptibility locus was identified, CD247, which represents another JIA susceptibility gene whose protein product is important in T-cell activation and signalling. The authors have also confirmed association of the PTPN2 and IL2RA genes with JIA, both reaching genome-wide significance in the combined analysis.
Results show that individuals who have a chemical-dependent family member use more health care services than the general population. Morbidity among the subject group appears to be similar to that among chemical-dependent individuals; diagnoses related to stress and trauma are common.