Does whole-exome sequencing and an iPSC-derived cardiomyocyte model provide a powerful platform for gene discovery in left ventricular hypertrophy?
Combining evidence from cutting-edge genetic and cellular experiments can enable identification of novel LVH risk loci.
Mesangial cells from single remaining kidneys in culture maintain an exaggerated capacity to produce IL-6 in response to IL-1. IL-6 was reported to enhance or inhibit mesangial cell proliferation in vitro. We suggest that the local over production of IL-6 by a single remaining kidney may play a role in regulating a sequence of physiological events in compensatory renal growth, initially stimulating mesangial cell proliferation and later blunting the process.