Do sleep deprivation and time of day interact with mild obstructive sleep apnea to worsen performance and neurobehavioral function?
The results suggest that subjects with mild OSA are not primarily different than subjects without OSA in their response to sleep deprivation or time-of-day influences. Consistent with previous literature, there were clear effects of sleep deprivation and time of day in all subjects. The finding that perception of daytime sleepiness after sleep deprivation was blunted in subjects with OSA compared with subjects without OSA, despite similar performance decrements, warrants further study.
A dose response to MAA haptenated protein-induced cell death is seen in antigen-presenting cells, lymphocytes, and hepatocytes in vitro. Recent reports have associated both apoptotic and necrotic cell death with the development of autoimmune disease; thus, it is possible that this may be one mechanism by which in vivo immunogenicity is mediated by aldehyde haptenated proteins.