Does inhibition of the multidrug transporter P-glycoprotein improve seizure control in phenytoin-treated chronic epileptic rats?
These findings show that TQD significantly improves the anticonvulsive action of PHT, thus establishing a proof-of-concept that the administration of AEDs in combination with P-gp inhibitors may be a promising therapeutic strategy in pharmacoresistant patients.
Red hair seems to be a distinct phenotype linked to anesthetic requirement in humans that can also be traced to a specific genotype.