Do hypercholesterolaemia and treatment with statins alter L-arginine-induced changes of renal haemodynamics?
In contrast to studies performed in the vasculature of the human forearm or the coronary circulation, our results suggest that hypercholesterolaemia is not associated with an impaired L-arginine-induced renal vascular relaxation.
The results support the idea that membranes containing more cardiolipin and more sphingolipids and having higher levels of saturation are more resistant to oxidation and protect cells from oxidative stress. Development of a therapy to increase sphingomyelins and lipid saturation in the lens may delay the onset of cataract.