Does levosimendan cardioprotection reduce the metabolic response during temporary regional coronary occlusion in an open chest pig model?
Levosimendan used throughout myocardial ischemia-reperfusion might have a cardioprotective affect on the response to myocardial ischemia as compared with levosimendan started during the ischemia.
SAMe depletion occurs already after 8 weeks of alcohol feeding and is fully corrected by PPC, in parallel with the prevention by PPC of the alcohol-induced oxidative stress. Since phosphatidylcholines (PCs) are produced in the liver via methylation of phosphatidylethanolamine by SAMe, it is likely that PPC, by providing PCs, decreases the utilization of SAMe and thereby contributes to its restoration, with replenishment of GSH and correction of the alcohol-induced oxidative stress.