Do prolonged esophageal acid exposures induce synaptic downscaling of cortical membrane AMPA receptor subunits in rats?
This study along with our previous findings suggests that synaptic AMPA receptor subunits expression and phosphorylation may be involved bidirectionally in both esophageal acid-induced neuronal sensitization and acid-dependent homeostatic plasticity in cortical neurons. The impairment of homeostatic compensatory mechanism as observed following early-in-life acid exposure could be the underlying mechanism of heightening cortical sensitization and esophageal hypersensitivity in patients with gastroesophageal reflux disease.
Elevated Lp-PLA2 levels predict CHD events in apparently healthy older adults, independent of CHD risk factors.