Does rectal acetaminophen reduce morphine consumption after major surgery in young infants?
Acetaminophen, as an adjuvant to continuous morphine infusion, does not have an additional analgesic effect and should not be considered as standard of care in young infants, 0-2 months of age, after major thoracic (non-cardiac) or abdominal surgery.
Our findings question the applicability of cost-effectiveness analyses that assume constant returns to scale.