Does insulin therapy improve islet functions by restoring pancreatic vasculature in high-fat diet-fed streptozotocin-diabetic rats?
The results suggest that insulin treatment improves islet recovery by increasing angiogenesis in the pancreas. The mechanism is related to the induction of VEGF and VEGFR2 expression in diabetic rats.
Our results show that the LMP2 proteasome subunit can directly influence both MHC class I-restricted antigen presentation and class I surface expression.