Is sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells?
These findings demonstrate that sustained response to IFN/RBV treatment for patients with CHC is closely associated with increased dynamism of NK and NKT cells in the liver.
Metastatic competence of osteosarcoma cells is dependent on efficient mRNA translation during stressful periods of metastatic progression and the mTOR inhibitor, rapamycin, can mitigate this translation and inhibit metastasis in vivo. Our data suggest that mTOR pathway inhibitors should be reconsidered in the clinic using rationally designed dosing schedules and clinical metrics related to metastatic progression.