Is tacrolimus dose requirement in renal transplant recipients significantly higher when used in combination with corticosteroids?
A higher tacrolimus dose is required to reach target concentrations when used in combination with corticosteroids.
NOD.c3c4 and NOD control mice show marked differences in the gut microbiota. GF NOD.c3c4 mice develop a milder biliary affection compared with conventionally raised NOD.c3c4 mice. Our findings suggest that the intestinal microbiota contributes to disease in this murine model of biliary inflammation.