Does glyburide prevent isoflurane 's reducing effects on hydroxyl radical formation in the postischemic reperfused rat heart?
The results suggest that isoflurane reduces hydroxyl radical formation, at least in part, through activation of K(ATP) channels.
These results indicate that JTE-522 selectively inhibits PG production mediated by COX-2 in inflammatory tissues. JTE-522 may thus represent a novel type of anti-inflammatory drug without adverse effects on the gastro-intestinal tract.