Is the protective effect of moderate hypothermia during intestinal ischemia-reperfusion associated with modification of hepatic transcription factor activation?
The protective effect of moderate hypothermia on liver is not mediated by HSP expression at this time-point. Hypothermia may act by decreasing hepatic STAT activation, supporting the potential therapeutic role of moderate hypothermia. Modulation of STAT activation may also provide novel therapeutic targets.
Supplementation with creatine or creatine precursors almost normalised low muscle PCr/Pi ratios of patients with GA.