Are [ Volumes of total prostate and transitional zone positively correlated with age in benign prostatic hyperplasia patients ]?
TPV and TZV increase with age in BPH patients, the latter even more obviously than the former.
This work, using a novel and robust statistical approach demonstrates that, although a "second hit" mechanism is not likely the predominant mode of action for epigenetic dysregulation in cancer, the patterns of methylation events are associated with the patterns of allele loss. Our work further highlights the utility of integrative genomics approaches in exploring the driving somatic alterations in solid tumors.