Is vulnerability to oxygen radicals more important than impaired repair in hepatocytic deoxyribonucleic acid damage in aging?
The low repair capacity in advanced age depends on a subpopulation of cells showing high DNA vulnerability to hydrogen peroxide. Therefore, an increase in the proportion of hepatocytes exhibiting high vulnerability to oxygen radicals is more important than the deterioration in DNA repair capacity in the age-related increase in DNA damage.
In ICU-resuscitated patients, targeting only ScvO(2) may not be sufficient to guide therapy. When the 70% ScvO(2) goal-value is reached, the presence of a P(cv-a)CO(2) larger than 6 mmHg might be a useful tool to identify patients who still remain inadequately resuscitated.