Is miR-146b highly expressed in adult papillary thyroid carcinomas with high risk features including extrathyroidal invasion and the BRAF ( V600E ) mutation?
Our results show the potential importance of miR-221, miR-222, and miR-146b in determining the aggressive properties of PTCs and highlight the need to identify the gene targets of these miRNAs.
These findings indicate that administration of a low dose of TNF-alpha can induce cross-tolerance to endotoxin by induction of endogenous anti-inflammatory mechanisms.