Are polycomb homologs involved in teratogenicity of valproic acid in mice?
We propose that, during embryonic development, VPA may affect the gene silencing pathway mediated by the Polycomb group complex. The epigenetic mechanism of VPA teratogenicity on anteroposterior patterning is suspected.
TIMP-1 may counteract glucolipotoxicity induced β-cell death via a PI-3 kinase pathway.