Are baseline and amphetamine-stimulated dopamine activity related in drug-naïve schizophrenic subjects?
In drug-naïve patients with schizophrenia but not in control subjects, stimulated and baseline DA release are both increased and positively correlated. At the neuronal level this association suggests that capacity for storage in presynaptic terminals, measured with the amphetamine paradigm, and baseline intrasynaptic DA release, measured with the alpha-methyl-para-tyrosine (alpha MPT) paradigm, are associated in schizophrenia, both consistent with increased midbrain DA cells activity.
Our study results have sufficiently shown that the relationship of a number of factors (age, primary histologic findings, smaller peritoneal trauma) had an important impact on a significant difference in reoperation rate between vaginal, laparoscopic and namely abdominal hysterectomies in female patients with preserved adnexa.