Does human stanniocalcin-1 block TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells?
STC1 maintains endothelial permeability in TNF-alpha-treated HCAECs through preservation of tight junction protein expression, suppression of superoxide anion production, and inhibition of the activation of NFkappaB and JNK, suggesting an important role for STC1 in regulating endothelial functions during cardiovascular inflammation.
Older adults enrolled in PICT with more symptoms may sacrifice QOL for experimental treatment.