Does silencing of Apurinic/Apyrimidinic Endonuclease 1 inhibit the Growth and Migration in Ovarian Cancer Cell via Activator-Protein-1 Signaling?
Overexpressed APE1 promotes ovarian cancer growth and metastasis. Downregulated APE1 could suppress cell activity via AP-1 pathway, suggesting that APE1 gene may be a potential therapeutic target for ovarian cancer.
Genetic factors are important for SOC, but genetic influences are much greater in supportive family environments. This emphasizes the importance of childhood home for the development of strong SOC.