Does microRNA-204-5p regulate epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4?
Our data provide firm evidence of a role for miR-204-5p in the direct regulation of EMT through its targeting of SMAD4 and, consequently, TGF-β signaling. Because of its ability to repress the EMT, miR-204-5p may be a novel target for PCO therapeutic intervention.
RADPs were equivalent to LDPs in nearly all measures of outcome and safety but significantly reduced the risk of conversion to open resection, despite a statistically greater probability of malignancy in the robotic cohort. We concluded that robotic assistance may broaden indications for minimally invasive pancreatectomy.