Do clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia?
hNSC therapy represents a promising treatment option for critical limb ischemia.
This study provides direct evidence in vitro that exposing isoflurane to HBVECs can trigger HIF-1α activation, leading to lower protein levels of occludin, and increased permeability of the BBB.