Is integrin engagement-induced inhibition of human myelopoiesis mediated by proline-rich tyrosine kinase 2 gene products?
These studies indicate that PYK2 gene products mediate integrin-induced signals that regulate myelopoiesis.
In patients with SSc, potentially life-threatening complications and clinical symptoms with high impact on the quality of life occur independently from the extent of skin sclerosis. The diagnosis in SSc patients with a low mRSS could be missed or they could be insufficiently treated.