Cerebral hemodynamic changes induced by simulated tracheal intubation: a possible role in perioperative stroke?
Simulated TI is safe yet induces distinct and potentially detrimental flow abnormalities. Individuals identified with the biological markers of hypoplasia, carotid and vertebral occlusion, severe stenosis, or prior ischemic vascular disease should receive special attention to neck position not only during surgery but also in the postoperative period. Sustained neck hyperextension greater than 12 minutes appears to be a neglected potential hemodynamic factor that may play a pivotal role in the pathogenesis of perioperative stroke.
Hemithorax irradiation induces time-dependent pneumonitis and fibrosis in C57BL/6J mice. While hemithorax irradiation with 12.5 Gy is sufficient to induce lung inflammation, it is below the threshold for collagen deposition and fibrosis development by day 210.