Does high-dose chlorogenic acid induce inflammation reactions and oxidative stress injury in rats without implication of mast cell degranulation?
High-dose, but not Low-dose CA induced inflammation reaction, and in this process an imbalance between oxidant and antioxidant mechanism may be involved, providing more information for better understanding the rationale behind the adverse effects of CA.
Our findings demonstrate the importance of the E3 ubiquitin ligase synoviolin in liver fibrosis.