Does endoxifen ( 4-hydroxy-N-desmethyl-tamoxifen ) have anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen?
Since endoxifen is present at greater concentrations than 4-OH-Tam in human plasma of breast cancer patients receiving chronic tamoxifen, these results provide further evidence that endoxifen is as important as, or more important than, 4-OH-Tam to the anti-estrogenic action of tamoxifen.
Our study shows that the use of a new hemostatic devices reduce significantly OT and EBL in children underwent renal ablative surgery for benign pathologies compared with the use of monopolar coagulation.