Does 5alpha-dihydrotestosterone inhibit 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells?
We demonstrated, for the first time, that DHT reduces the ability of 1alpha,25-(OH)(2)D(3) to induce 24-hydroxylase expression. Our results not only support the earlier finding of a cross-talk between androgen and vitamin D in human prostate cancer cells but also provide a possible mechanism how androgen and vitamin D signaling pathways may interact.
Non-O blood type is not associated with either 30-day cardiovascular complications or long-term mortality in vascular surgery patients.