Is rGS9-1 required for normal inactivation of mouse cone phototransduction?
(1) The amplitudes and sensitivities of the cone-driven responses indicate that cones and cone-driven neurons in RGS9-1 -/- mice have normal generator currents. (2) The greatly retarded recovery of cone-driven responses of RGS9-1 -/- mice relative to those of WT mice establishes that RGS9-1 is required for normal inactivation of the cone phototransduction cascades of both UV- and M-cones.
Infants with recurrent wheezing who had a positive stringent API already had higher FE(NO) levels than those with a negative API. This finding needs to be corroborated in a larger prospective study.