Is sensorimotor gating in mice disrupted after AM404 , an anandamide reuptake and degradation inhibitor?
The data indicate that AM404 (5 mg/kg) acts as a psychodysleptic, altering PPI through stimulation of cannabinoid CB1 receptors, pointing to a possible "psychosis-like" state after enhancement of anandamide bioavailability. The startle response was enhanced only following a lower AM404 dose (2.5 mg/kg), indicating that AM404 induced hyperreactivity at a dose that did not affect PPI, further reinforcing a selective disruption of PPI.
Routine postoperative nasogastric decompression is unnecessary after radical gastrectomy even in the presence of gastric outlet obstruction.