Is polymorphism in signal transduction a major route through which osteoarthritis susceptibility is acting?
The FRZB, ASPN and CALM1 results are compelling and highlight that polymorphism in signal transduction pathways is a major component of osteoarthritis susceptibility. This is an exciting observation since signal transduction pathways are malleable and therefore potentially amenable to intervention and modification.
Endogenous catecholamines appear to act on alpha(1D) receptors in the urothelium to facilitate mechanosensitive bladder afferent nerve activity and reflex voiding.