Do somatic copy number alterations predict response to platinum therapy in epithelial ovarian cancer?
We established that amplifications in 14q32.33 were associated with reduced OS, PFS, PFI and platinum resistance in three independent cohorts, suggesting that AKT1 amplifications act as a potentially predictive marker for EOC treated with platinum-based chemotherapy.
In this study, an ANN-based equation to estimate VO(2max) from 20 mSRT performance (stage), sex, age, weight, and height in adolescents was developed and cross-validated. The newly developed equation was shown to be more accurate than Léger's. The proposed model has been coded in a user-friendly spreadsheet.