Do histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts?
HDAC inhibitors are most efficient at amplifying transient transgene expression in NHDF cells. This suggests that NHDF cells may be most suitable as transgene targets for transient gene transfection using HDAC inhibitors. Specific HDAC inhibitors may not prove so useful for treating genetic dermatoses requiring cells stably expressing the correct gene, but may be advantageous in treating nonhealing cutaneous wounds or cancer.
Lower limb IPC protects against systemic inflammation and acute lung injury in lower limb I/R injury.