Does incomplete Dll4/Notch signaling inhibition promote functional angiogenesis supporting the growth of skin papillomas?
Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Dll4 targeting therapies.
Chronic hyperammonemia may negatively affect attention. Eating breakfast improves attention and executive functions of patients with MHE. Prolonged periods of starvation may be partly responsible for these changes. This trial was registered at clinicaltrials.gov as NCT01083446.