Is the expression of apoptosis inducing factor ( AIF ) associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer 's disease?
Taken together, these data suggest that AIF is likely to play a region-specific role in AD-related caspase-independent PCD, which is consistent with aging-associated mitochondrial impairment and oxidative stress.
ANK, by modulating local PP(i), controls cervical cementum apposition and extracellular matrix. Loss of ANK created a local environment conducive to rapid cementogenesis; therefore, approaches modulating PP(i) in periodontal tissues have potential to promote cementum regeneration.