Does fluoxetine increase the expression of NCAM140 and pCREB in rat C6 glioma cells?
Our findings indicate that fluoxetine treatment regulates neuronal plasticity and neurite outgrowth by phosphorylating and activating CREB via the NCAM140 homophilic interaction-induced activation of the Ras-MAPK pathway.
The results indicate that 1) leptin is able to regulate the expression of the 3βHSD protein in a dose-dependent manner; and 2) leptin seems to exert its dual effects on P synthesis on different targets in a dose-dependent manner.