Does hepatocyte growth factor gene therapy slow down the progression of diabetic nephropathy in db/db mice?
The HGF gene delivery thus appeared to slow down the aggravation of diabetic nephropathy in db/db mice by attenuating progression from the hyperfiltration phase into the sclerotic phase through antiapoptotic and antifibrotic actions. The present findings suggest that the HGF gene delivery can be a novel therapeutic approach against diabetic nephropathy.
Our results suggest that intrathecal inflammation increases in association with the severity of MTA in AD.