Do novel genetic markers in the 5'-flanking region of ANKH are associated with ankylosing spondylitis?
Our results indicate that ANKH-OR and ANKH-TR are novel genetic markers that are significantly associated with AS.
This study reveals that the binding properties of Nanobodies need to be compatible with achieving an occupancy of >95% saturation of the parasite surface VSG in order to exert an anti-trypanosomal activity. As such, Nb-based approaches directed against the VSG target would require binding to an accessible, conserved epitope with high affinity.