Is thiazide use associated with reduced risk for incident lower extremity fractures in men with spinal cord injury?
Thiazide use is common in men with SCI and is associated with a decreased likelihood for lower extremity fractures.
The physiological signal for T-cell activation, antigen recognition, is a three-step process reminiscent of the three steps previously observed in the interaction between neutrophils and endothelial cells. During these successive steps, a mobile, weakly interacting T cell is transformed into an immobile cell fully engaged in the activation pathway. Thus, antigenic recognition is not instantaneous, but evolves slowly by progressive amplification of the signal given by a few antigen molecules, eventually resulting in T-cell activation.