Does smurf2 E3 ubiquitin ligase modulate proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner?
Our results therefore suggest a novel relation between Smurf2 and CNKSR2 thereby regulating AKT-dependent cell proliferation and invasion. Owing to the fact that PI3K-AKT signaling is hyperactivated in various human cancers and that Smurf2 also regulates cellular transformation, our results indicate that Smurf2 may serve as a potential molecule for targeted cancer therapy of certain tumour types including breast cancer.
Primary tumor location is an important prognostic factor for survival of Chinese women with T1-2N0M0 breast cancer.