Does endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 target misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation?
The present findings indicate that the UPR ERAD pathway can dispose of HLA-B27 dimers, thus presenting a potential novel therapeutic target for modulation of HLA-B27-associated inflammatory disease.
Accurate determination of insertion depth of the cochlear implant array can be determined by assessment of the implant tip on axial, coronal, and oblique CT images, but description of the tip location can be inaccurate due to lack of standardized terminology. We propose using a standardized terminology to communicate tip location by using the round window as the zero reference and quadrant numbering to describe cochlear turns. This results in improvement in radiology report accuracy and consistency regarding the cochlear implant insertion depth.