Does cD45 regulate Src family member kinase activity associated with macrophage integrin-mediated adhesion?
Using primary bone marrow macrophages, these studies demonstrate that CD45 regulates Src family kinases and is required to maintain macrophage adhesion. CD45 decreases Src family kinase activity by dephosphorylating the tyrosine residue located within the kinase domain.
A1AT reduces lung bacterial infection in mice in part by preventing NE-mediated SPLUNC1 degradation.