Does intravenous or oral high-dose N-acetylcysteine in addition to saline prevent contrast-induced nephropathy assessed by cystatin C?
In this study, there was no detectable benefit of either high-dose oral or i.v. NAC over an aggressive hydration protocol in patients with moderate-to-severe renal insufficiency.
The posterolateral region of the endplate provides the greatest resistance to subsidence while the central region provides the least resistance. A larger-diameter solid support has the greater MLF and the lower the risk of subsidence, suggesting a more efficient transfer of force to the endplate with the hollow indenters. Parameters such as the geometry of structural support and the position and preparation of the endplate can influence the resistance of an interbody support to subside. Partial removal of the endplate may provide both, for adequate mechanical advantage and a highly vascular site for fusion.