Are serum leptin levels influenced by physical training in type 2 diabetes mellitus patients?
No effect of physical training on leptin levels was detectable in elderly, obese type 2 diabetes mellitus patients.
Sorafenib alters macrophage polarization, reduces IGF-1-driven cancer growth in vitro and partially inhibits macrophage activation in vivo. Thus macrophage modulation might contribute to the anti-cancer activity of sorafenib. However, more efficient macrophage-directed therapies are required.