Does sirtuin 1 ( SIRT1 ) activation mediate sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice?
Our study shows that activation of SIRT1 following SIL treatment plays an essential role in mediating the SIL-induced cardioprotection against I-R injury. This newly identified SIRT1-activating property of SIL may have enormous therapeutic implications.
Administration of NAC prior to or shortly after circulatory arrest results in a marked reduction of inflammation during the warm ischemic phase.