Does n-terminal domain of soluble epoxide hydrolase negatively regulate the VEGF-mediated activation of endothelial nitric oxide synthase?
In addition to epoxide hydrolase activity, phosphatase activity of sEH plays a pivotal role in the regulation of eNOS activity and NO-mediated EC functions.
Cholinergic mechanisms do not appear to be responsible for the nasal congestive response to irritant provocation.