Does navβ4 regulate fast resurgent sodium currents and excitability in sensory neurons?
INaRs are associated with inherited and acquired pain disorders. However, our ability to selectively target and study this current has been hindered due to limited understanding of how it is generated in sensory neurons. This study identified Navβ4 as an important regulator of INaR and excitability in sensory neurons. As such, Navβ4 is a potential target for the manipulation of pain sensations.
A decrease in HLA class I molecules on the cell surface is correlated with a greater expansion of the leukemic clone.