Does rFX1 regulate CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1?
RFX1 recruits SUV39H1 to the promoter regions of the CD11a and CD70 genes in CD4(+) T cells, thereby regulating local H3K9 tri-methylation levels. These findings shed further light on the central role of RFX1 down-regulation in the epigenetic de-repression of auto-immune genes in SLE.
DHEAS interference in testosterone assays is a feature of many routine testosterone methods, and occurs in both male and female matrices.