Are cytosine-based nucleoside analogs selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress?
We propose that cytarabine-based chemotherapy regimens may represent a tumour-selective treatment strategy for mismatch repair-deficient cancers.
The results of the study indicate that doctors can profit by preparing a dialogue with parents who are in doubt about MMR vaccination. Especially it seems that a profound knowledge of the scientific evidence of virus-caused diseases, of their risks and of immunology is necessary to balance parents' most essential misconceptions and their reasons for not choosing vaccination.