Does suppression of histone deacetylation promote the differentiation of human pluripotent stem cells towards neural progenitor cells?
Our study reveals that HDACs, especially HDAC3, negatively regulate the differentiation of hPSCs towards NPCs at an earlier stage of neural differentiation. Moreover, HDAC3 might function by forming a repressor complex with its cofactor SMRT during this process. Thus, our findings uncover an important epigenetic mechanism of HDAC3 in the differentiation of hPSCs towards NPCs.
The sex of the practitioner did not significantly influence patient responses to sensitive questions about their sexual behaviour.