Is proximal tubule dysfunction dissociated from endothelial dysfunction in normoalbuminuric patients with type 2 diabetes mellitus : a cross-sectional study?
The increase in urinary α(1)-/β(2)-microglobulin precedes the stage of albuminuria. It may be assumed that early DN is related to PT dysfunction. Endothelial dysfunction plays a pivotal role in the brain vasculature, while its involvement in the development of early DN is not conditional on the occurrence of albuminuria.
Intensive exercise favors a negative energy balance by dually affecting energy expenditure and energy intake without changes in appetite sensations, suggesting that adolescents are not at risk of food frustration.