Are mutants in the mouse NuRD/Mi2 component P66alpha embryonic lethal?
mp66alpha is an essential gene, required for early mouse development. The lethal phenotype supports a role in execution of methylated DNA silencing.
Advances in imaging modalities made during the study period did not improve our ability to discriminate between benign inflammatory conditions and neoplastic disease. The inability to distinguish benign from neoplastic disease justifies the use of pancreaticoduodenectomy in the appropriate clinical setting.