Does endothelial-specific deletion of connexin40 promote atherosclerosis by increasing CD73-dependent leukocyte adhesion?
Cx40-mediated gap junctional communication contributes to a quiescent nonactivated endothelium by propagating adenosine-evoked antiinflammatory signals between endothelial cells. Alteration in this mechanism by targeting Cx40 promotes leukocyte adhesion to the endothelium, thus accelerating atherosclerosis.
comprehensive and unambiguous national eligibility criteria should be introduced to reflect clinical needs and provide equity of access.