Does genetic variation in the B-type natiuretic peptide pathway affect BNP levels?
Genetic variation in NPPB significantly impacts BNP levels after adjustment for clinical/physiologic factors. The full linear regression model predicted up to a 50% relative difference in BNP levels between NPPB -381 T > C genotype groups. This suggests that NPPB sequence variants affect BNP physiology, possibly via transcriptional regulation. Further studies are needed to define whether these variants impact the clinical interpretation of BNP levels.
We showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP.