Does the ldis1 lens mutation in RIIIS/J mice map to chromosome 8 near cadherin 1?
We have discovered and mapped a recessive mutation to mouse chromosome 8 between 105 and 109 Mb. Homozygous mutant mice have a selective and severe effect on lens integrity. On the basis of the phenotype and the locus position, several candidate genes have been identified.
The highest frequency of funisitis was observed in cervical insufficiency among cases with spontaneous preterm birth.