Is lower AMP-activated protein kinase level associated with the vulnerability of coronary atherosclerotic plaques by attenuating the expression of monocyte autophagy?
Therefore, our work is novel in showing that AMPK of PBMs may decrease plaque vulnerability and subsequent plaque rupture through activation of autophagy.
These results indicate that ZOL-mediated induction of CLU can be attenuated by OGX-011, with synergistic effects on delaying progression of osteosarcoma.