Does mannose-binding lectin promote local microvascular thrombosis after transient brain ischemia in mice?
MBL promotes brain damage and functional impairment after brain ischemia/reperfusion in mice. These effects are secondary to intravascular thrombosis and impaired relative cerebral blood flow during reperfusion. Argatroban protects WT mice, but not MBL knockout mice, emphasizing a role of MBL in local thrombus formation in acute ischemia/reperfusion.
EP warrants further evaluation as a therapeutic agent to ameliorate postoperative ileus.