Does angiopoietin-1 inhibit mouse glomerular endothelial cell senescence via Tie2 receptor-modulated ERK1/2 signaling?
The present studies suggest that Ang1 inhibits H(2)O(2)-induced senescence in MGECs via the Ang1-Tie2-ERK1/2 signaling pathway.
The association between the risk alleles of the two SNPs studied and levels of proinsulin in plasma, identified when adjusting for insulin sensitivity using euglycaemic-hyperinsulinaemic clamp measurements in this study, is an important novel finding.