Is previous prescription of β-blockers associated with reduced mortality among patients hospitalized in intensive care units for sepsis?
As far as we are aware, this pharmacoepidemiologic assessment is the largest to examine the potential association of previous β-blocker prescription and mortality in patients with sepsis. Chronic prescription of β-blockers may confer a survival advantage to patients who subsequently develop sepsis with organ dysfunction and who are admitted to an intensive care unit. Prospective randomized clinical trials should formally test this hypothesis.
Vaginal hysterectomy in larger non-prolapsed uteri takes longer (mean 38 min longer) and is associated with more blood loss (mean increase 242 ml) compared to normal-sized uteri but is not associated with a significant increase in complication rates.