Does tenuigenin protect dopaminergic neurons from inflammation-mediated damage induced by the lipopolysaccharide?
Our results suggest that TEN may play a role in protecting dopaminergic neurons against inflammatory challenge.
These results indicated that Ac2-26 exerted broad inhibitory effects on airway inflammation and hyperresponsiveness in a rat model of asthma. Exogenous PGD₂ reversed the inhibitory effects of AC2-26 on eosinophil recruitment. Ac2-26 exhibited anti-asthmatic, immunomodulatory activity that was substantially mediated by decreasing PGD₂ production and its CRTH2 receptor expression in vivo.