Are protein C levels regulated by a quantitative trait locus on chromosome 16 : results from the Genetic Analysis of Idiopathic Thrombophilia ( GAIT ) Project?
These results illustrate the application of genomic scans to identify the genetic determinants of quantitative variation in a component of the hemostatic pathways. They provide strong evidence for a locus (QTL) on chromosome 16 that influences PC levels.
We show that HtrA protease and chaperone activities contribute differently to C. jejuni's interaction with mammalian host cells, with the chaperone activity playing the major role in host cell binding.