Does 16,16-Dimethyl prostaglandin E2 reverse focal mucosal ischemia associated with stress ulcers?
(1) gastric mucosal ulceration is preceded by focal decreases in gastric mucosal blood flow, and (2) topical Dm-PGE2 reverses focal mucosal ischemia during hemorrhagic shock. Dm-PGE2's ability to reverse focal ischemia suggests a mechanism for prostaglandin-mediated cytoprotection.
The high rate of UPase staining in biopsies from patients with oral SCC may be a prognostic marker for these individuals.