Does all-trans retinoic acid induce XAF1 expression through an interferon regulatory factor-1 element in colon cancer?
XAF1 participates in ATRA-induced growth suppression through IRF-1-mediated transcriptional regulation.
Our institution's 5-year OS (93.3%) for Z11-eligible patients closely resembled those from the Z11 trial (92.5%) and our 10-year data provide evidence of what to expect for Z11-enrolled patients with continued follow-up. Larger tumor, nonductal, ER(+), PR(+), and HER2- were predictive for further +LNs on ALND, which might reflect surgical bias.