Does inhibition of notch1-dependent cardiomyogenesis lead to a dilated myopathy in the neonatal heart?
Notch1 signaling is a critical determinant of CSC growth and differentiation; when this cascade of events is altered, cardiomyogenesis is impaired, physiological cardiac hypertrophy is prevented, and a life-threatening myopathy supervenes.
People with IEI-EMF might be able to detect the presence of the MF to a small extent; however, their symptom reports are connected to perceived exposure.