Are higher levels of cystatin C associated with worse cognitive function in older adults with chronic kidney disease : the chronic renal insufficiency cohort cognitive study?
In individuals with CKD, higher serum cystatin C levels were associated with worse cognition and greater likelihood of poor cognitive performance on attention, executive function, and naming. Cystatin C is a marker of cognitive impairment and may be associated with cognition independent of eGFR.
Theoretically, our findings indicated that cognitive-control representations (e.g., working memory accuracy) could serve as the optimal frame of reference for later retrospective metacognitive judgments.