Does the inhibition of PARP but not EGFR result in the radiosensitization of HPV/p16-positive HNSCC cell lines?
PARP-inhibition effectively radiosensitizes HPV-positive HNSCC cells and may therefore represent a viable alternative to chemotherapy possibly even allowing for a reduction in radiation dose. For the latter, PARP-inhibition may be combined with the inhibition of Chk1. In contrast, the inhibition of EGFR cannot be expected to radiosensitize HPV-positive HNSCC through the modulation of cellular radiosensitivity.
Even a modest thyroid hormone excess is associated with a reduced physical function in elderly men.