Does aBT-888 enhance cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells?
PARPi mediated potentiation of TMZ is independent of TMZ sensitivity and can override MGMT(-) mediated resistance when administered simultaneously. Response to combination therapy was associated with increased double strand breaks induction, and coincided by increased apoptosis and autophagy. PARPi addition potentiates TMZ treatment in primary GSCs. PARPi could potentially enhance the therapeutic efficacy of the standard of care in GBM.
The COX-2-1195 AA genotype may render subjects more susceptible to diffuse-type GC.