Does lack of Galectin-3 prevent Cardiac Fibrosis and Effective Immune Responses in a Murine Model of Trypanosoma cruzi Infection?
These results suggest that galectin-3 is strongly involved in Chagas disease, not only in the immune response against T. cruzi, but also in mediating cardiac tissue damage.
These data indicate that abrogating PGE2's actions during burn sepsis can restore the balance in bone marrow granulocyte and monocyte production, further consolidating the pivotal role PGE2 plays in the pathogenesis of burn sepsis.