Is long-term metformin use associated with decreased risk of breast cancer?
A decreased risk of breast cancer was observed in female patients with type 2 diabetes using metformin on a long-term basis.
We first investigated whether miR-499 modulates polβ, and observed the influence of miR-499 up-regulation on the sensitivity of EC cell lines to cisplatin treatment. Our study paves the way for more insightful understanding and application of chemotherapy in esophageal cancer in the future.