Is high density lipoprotein turnover dependent on peroxisome proliferator-activated receptor α in mice?
We conclude that the plasma HDL turnover rate is retarded in PPARα-null mice, perhaps more prominently in females.
The different splice variants in RUNX2 gene in the two cell lines might be related to their different phenotypes. The less differentiated stage of MG63 could also be related to bFGF over-production and more bFGF receptors. The consequent increase in bFGF-bFGF receptor binding could explain the bFGF differentiative effects on MG 63. We suggest an autocrine role of bFGF endogenous release in controlling the different osteosarcoma phenotypes.