Does de novo sequencing of circulating miRNAs identify novel markers predicting clinical outcome of locally advanced breast cancer?
Our study indicates that certain miRNAs can serve as potential blood-based biomarkers for NCT response, and that miR-122 prevalence in the circulation predicts BC metastasis in early-stage patients. These results may allow optimized chemotherapy treatments and preventive anti-metastasis interventions in future clinical applications.
Extensive preparation for cardiac surgery had a positive effect on physical wellbeing and anxiety in patients who before the operation had relatively few complaints or indicated that they were anxious. Patients who reported less anxiety and patients who felt less well physically before the operation benefited more from a information programme.