Do [ Notochord cells enhance proliferation and phenotype-keeping of intervertebral disc chondroid cells ]?
The notochord cells are conducive for the proliferation and phenotype-keeping of the chondroid cells and may play a key role in preventing degeneration of the disc.
These data indicate that STAT-1 is a key player in immune-mediated early beta-cell dysfunction and death. When considering the many effector mechanisms contributing to beta-cell death following islet transplantation, multiple combined interventions will be needed for prolongation of beta-cell survival in the autoimmune context of type 1 diabetes.