Is wnt signalling in human breast cancer : expression of the putative Wnt inhibitor Dickkopf-3 ( DKK3 ) frequently suppressed by promoter hypermethylation in mammary tumours?
DKK3 mRNA expression and consequently DKK3 protein expression become frequently downregulated during human breast cancer development due to aberrant methylation of the DKK3 promoter. Since DKK3 is thought to negatively regulate oncogenic Wnt signalling, DKK3 may be a potential tumour suppressor gene in normal breast tissue.
Regular transfusion which lowers stroke risk is associated with a significant reduction in PFH. A role for PFH in promoting stroke in SCD should be investigated.