Is [ Poorly-immunogenic tumor capable of inducing proliferation of CD4 ( + ) CD25 ( + ) regulatory T-lymphocytes in vitro ]?
Poorly-immunogenic tumor cells can induce the proliferation of TR cells, which may play an important role in tumor evasion.
Our findings suggest that amplification of the arterial contractile response to thrombin caused by platelet-derived mediators may be due to activation of protein kinase C. There may also be a protective role for the cerebrovascular endothelium since endothelium reduced the extent of augmentation of protein kinase C-mediated tone by vasoactive agents released by activated platelets. Thus, increased vascular responsiveness caused by activated platelets may in part be due to protein kinase C-mediated changes in the intracellular sensitivity to Ca2+.