Does endothelial-specific expression of mitochondrial thioredoxin promote ischemia-mediated arteriogenesis and angiogenesis?
These in vivo and in vitro data support that Trx2 maintains EC function by two parallel pathways-scavenging ROS to increase NO bioavailability and inhibiting ASK1 activity to enhance EC survival, facilitating ischemia-mediated arteriogenesis and angiogenesis.
Preinterventional arterial remodeling influenced the development of intimal hyperplasia after stenting.