Is endogenous fibrinolytic potential in tissue-plasminogen activator-modified thromboelastography analysis significantly decreased in dogs suffering from diseases predisposing to thrombosis?
Addition of t-PA activates fibrinolysis in TEG of blood from both healthy dogs and dogs with diseases predisposing to thrombosis. The significantly decreased fibrinolysis in diseased dogs suggests that this may be a potential prothrombotic risk factor in dogs.
In CF, platelet proinflammatory activity is increased at very young age already and might promote inflammation and tissue damage. On the other hand, platelets seem to downregulate the activation of their most important integrin (alpha(IIb)beta(3)) for clot formation.