Is hydrogen sulfide derived from periadventitial adipose tissue a vasodilator?
These results suggested PAT could endogenously generate H(2)S, which might act as an adipocyte-derived relaxing factor and contribute to the pathogenesis of hypertension.
Rosiglitazone can effectively attenuate activation of HTFs induced by TGF-β1 without obvious toxicity. The possible mechanism might be that rosiglitazone interferes with TGF-β/Smad signaling pathway.