Are iGF-I and IGF binding protein-3 levels during initial GH dosage step-up indicators of GH sensitivity in GH-deficient children and short children born small for gestational age?
IGFs increase during initial GH therapy, thus raising questions about short-term IGF generation tests. (I) In terms of IGF generation, substantially lower sensitivity to GH was observable in SGA. (II) Higher GH sensitivity during first year catch-up growth is associated with GHD, but in SGA it is attributable to increases in IGF. A wider range of GH dosages needs to be explored in order to gain further insight into the relationship between GH dose, IGF levels, and growth. Monitoring IGFs is a practical means for exploring GH sensitivity during dosage stepping up.
Idebenone failed to slow cognitive decline in AD that was of sufficient magnitude to be clinically significant.