Does the novel NF-kappaB activation inhibitor dehydroxymethyl-epoxyquinomicin suppress anti-Thy1.1-induced glomerulonephritis in rats?
DHMEQ inhibited NF-kappaB and thereby suppressed the inflammatory renal responses in rats with Thy1.1 GN.
Kaerophyllin inhibited AB-induced LX-2 activation and migration with downregulation of Akt/ERK phosphorylations and NF-κB activity. Our study suggests a novel platform for screening anti-fibrotic compounds with ABs.