Is laparoscopic colorectal cancer surgery associated with an increased risk in obese patients?
With sufficient experience, laparoscopic colorectal cancer surgery is feasible and safe in obese Chinese patients.
This report documents that half of T790M-positive EGFR-mutant lung cancers treated with rociletinib are T790-wild-type upon progression, suggesting that T790-wild-type clones can emerge as the dominant source of resistance. We show that tumor heterogeneity has important clinical implications and that plasma ctDNA analyses can sometimes predict emerging resistance mechanisms.