Does 12/15-Lipoxygenase gene disruption attenuate atherogenesis in LDL receptor-deficient mice?
12/15-LO plays a dominant role in promoting atherogenesis in LDL-R(-/-) mice.
ACE2 inhibits myocardial collagen accumulation and improves LV remodeling and function in a rat model of diabetic cardiomyopathy. Thus, ACE2 provides a promising approach to the treatment of patients with diabetic cardiomyopathy.