Does tumor necrosis factor-alpha potentiate RhoA-mediated monocyte transmigratory activity in vivo at a picomolar level?
Picomolar concentrations of TNF-alpha in the bloodstream may prime the RhoA-dependent activities of circulating monocytes to enhance recruitment to active inflammatory foci.
The signatures were identified as risk predictors that patients who had a high-risk score tended to have unfavorable outcome, demonstrating their potential for personalizing cancer management.