Are pancreatic duct glands distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia?
PDG are distinct gland-like mucinous compartments with a distinct molecular signature. In response to injury, PDG undergo an Shh-mediated mucinous gastrointestinal metaplasia with PanIN-like features. PDG may provide a link between Shh, mucinous metaplasia, and neoplasia.
The present study demonstrated that the conjugation of TMC nanoparticles with antigens is an effective strategy for nasal vaccination.