Does mapping of a novel susceptibility locus suggest a role for MC3R and CTSZ in human tuberculosis?
These results demonstrate how a genomewide approach to the complex phenotype of human tuberculosis can identify novel targets for further research.
PRAME expression in neuroblastoma is extraordinarily common and was universally seen in patients with advanced-stage disease in our study. Furthermore, significant impact of PRAME expression on the outcome of patients was shown. Thus, PRAME may present a particularly attractive target for immunotherapeutic strategies in neuroblastoma.