Is inhibition of the tumor necrosis factor-alpha pathway radioprotective for the lung?
Radiation-induced lung TNF-alpha production correlates with early cell apoptosis and latent lung function damage. Inhibition of lung TNFR1 is selectively radioprotective for the lung without compromising tumor response. These findings support the development of a novel radioprotection strategy using inhibition of the TNF-alpha pathway.
Decreased expression of FREM1 in the nitrofen-induced CDH model may disturb the formation of the diaphragmatic mesenchyme, thus contributing to the development of diaphragmatic defects.