Does oral health affect self perceptions, parental ratings and video-based assessments of children's smiles?
Poor oral health is significantly related to children's smiling patterns and the way others perceived their smiles. Poor oral health may prevent children from expressing positive emotions, which can impact their social interactions and the way they feel about themselves.
In aggregate, these data suggest that the GAS5-derived snoRNAs are under control of p53 and that they have an important role in mediating the p53 response to DNA damage, which may not relate to their function in the ribosome. We suggest that these snoRNAs are not processed by DICER to form smaller snoRNA-derived RNAs with microRNA (miRNA)-like functions, but their precise role requires further evaluation. Furthermore, since GAS5 host snoRNAs are often used as endogenous controls in qPCR quantifications we show that their use as housekeeping genes in DNA damage experiments can lead to inaccurate results.