Is hedgehog-dependent regulation of angiogenesis and myogenesis impaired in aged mice?
The present study demonstrates that Hh signaling is impaired in aged mice because of Dhh and smoothened downregulation. Moreover, it shows that hegdehog-dependent regulation of angiogenesis and myogenesis involves distinct mechanisms.
These data suggest that mild cognitive impairment may be the earliest clinical manifestation of common age-related neurologic diseases.