Do antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription?
Glibenclamide and glimepiride are potential ligands of FXR and modulate activation and signaling.
In our institution, undercalls account for 28% of patients who meet trauma call criteria and in patients with moderately poor probability of survival undercall is associated with decreased survival. Although trauma team activation does not guarantee better survival, better compliance with trauma team activation protocols optimises processes of care and may translate into improved survival.