Does exogenous acid fibroblast growth factor inhibit ischemia-reperfusion-induced damage in intestinal epithelium via regulating P53 and P21WAF-1 expression?
P53 and P21WAF-1 protein accumulations are associated with intestinal barrier injury induced by I-R insult, while intravenous aFGF can alleviate apoptosis of rat intestinal cells by inhibiting P53 and P21WAF-1 protein expression.
Metformin, but not pioglitazone, decreased plasma ghrelin levels after the glucose load. This decrease may in part account for weight stability in type 2 diabetic patients treated with metformin.