Does enhanced glucocorticoid-induced leucine zipper in dendritic cells induce allergen-specific regulatory CD4 ( + ) T-cells in respiratory allergies?
This proof of concept study shows that the re-establishment of GILZ expression in patients' DCs to normal levels restores their capacity to activate allergen-specific IL-10-Tregs . We thus highlight the up-regulation of GILZ in DCs as a new interventional approach to restore the immune tolerance to allergens.
Only 1 intervention group.