Urinary prostate specific antigen: is the clinical use likely?
Determination of uPSA cannot differentiate BPH and CaP. However, in the group of pts. with proven localized CaP, uPSA can provide additional information concerning T-staging. Moreover, simultaneous monitoring of PSA and uPSA response on hormonal therapy, can provide an early recognition of androgen-indiferent CaP (AIPCA) and hormone-resistent CaP (HRPCA).
These results may provide novel guidelines towards improved strategies using VA extracts based on the inhibition of angiogenesis of tumors.