Do pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells Have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1?
The present study reports on a simple, low-cost, and reproducible method for the generation of multilineage-differentiating stress-enduring cells from human adipose tissue lipoaspirates without the aid of cell sorting and genetic manipulation methods. This stem cell population does not form teratoma in vivo when injected into immunodeficient mice and has immunomodulatory properties with potential therapeutic effects on immune disorders.
Elevated levels of PAI-1 activity and t-PA antigen measured in-hospital in STEMI patients were associated with AGR classified at 3-month follow-up. Additionally, changes in the levels of F(1+2) were more pronounced in patients with AGR compared with NGR. The data suggest an enhanced prothrombotic state after an acute STEMI in patients with AGR without known diabetes.