Does vaccination with SIVmac239Deltanef activate CD4+ T cells in the absence of CD4 T-cell loss?
We demonstrated in this study that SIVmac239Deltanef vaccination did not deplete CD4(+) T cells but transiently activated and expanded the memory cell population. However, increases in numbers and activation of memory CD4(+) T cells did not appear to influence protective immunity.
The prevalence of hVISA in Croatia is low, but there are some strains with reduced susceptibility to vancomycin. Unfortunately, because of lack of clinical data neither clinical correlation with laboratory findings nor therapeutic failures can be discussed.