Does demand flow facilitate spontaneous breathing during high-frequency oscillatory ventilation in a pig model?
In moderately lung-injured anesthetized pigs during HFO ventilation, demand flow facilitated spontaneous breathing and augmented gas exchange. Demand flow decreased total breathing effort as quantified by PTP. Imposed work caused by the HFO ventilator appeared totally reduced by demand flow.
Continuous treatment of SHRs with ACRS for 21 weeks reduced blood pressure, myocardial hypertrophy and the amount of interstitial and perivascular collagen, which indicated that ACRS could prevent hypertensive ventricular remodeling. This can be attributed to suppression of the sympathetic nervous and renin angiotensin aldosterone system through the inhibition of ERK 1/2, JNK and p38 MAPK pathways.