Do reactive oxygen species modulate endothelin-I-induced c-fos gene expression in cardiomyocytes?
These findings clearly indicate that Et-1 treatment to cardiomyocytes can induce ROS via Ras pathway and the increased ROS are involved in the increase of c-fos expression. Our studies thus emphasize the importance of ROS as second messengers in Et-1-induced responses on cardiomyocytes.
Tumor size can be a predictable surrogate of biological behavior in the preoperative period. When tumor size is 2.1-5 cm, transplantation should be considered first, irrespective of the underlying liver condition. In patients with tumors 5.1-10 cm in size, liver resection is preferred.