Does repetitive supply-demand ischemia with dobutamine increase glucose uptake in postischemic and remote myocardium?
Unlike repetitive coronary artery occlusion-reperfusion, repetitive supply-demand ischemia with dobutamine alters glucose uptake within the remote myocardium, possibly as a result of AMP kinase activation. Clinically, these data suggest that (18)F-FDG studies have a limited role in discriminating postischemic from remote myocardium after dobutamine stress.
This is the first report of dye-protein conjugates as tissue solders. These conjugates may have applications in ophthalmology.