Is mechanical dyssynchrony after cardiac resynchronization therapy for severely symptomatic heart failure associated with risk for ventricular arrhythmias?
Persistent or new radial dyssynchrony after CRT-D in severely symptomatic patients with heart failure with widened QRS complexes and reduced ejection fractions was associated with an increased rate of ventricular arrhythmias or death and appears to be a marker for a less favorable prognosis.
LOX-1 expression appears to be closely associated with TF expression, apoptotic events and the morphological vulnerability, suggesting the in vivo involvement of LOX-1 in the destabilization and rupture of atherosclerotic lesions and the subsequent thrombus formation. The present findings in hypercholesterolemic rabbits should help advance our understanding of the pathophysiology of atherosclerosis.