Is a High RORγT/CD3 Ratio a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer : Analysis of Helper T Cell Lymphocytes ( Th1 , Th2 , Th17 and Regulatory T Cells )?
This study confirmed a high RORγT/CD3 ratio as a strong prognostic marker for postoperative survival. The immunohistochemistry results suggest that Th17 may affect lymph node metastasis in CRC. If new immunotherapies reducing Th17 expression are established, they may improve the efficiency of cancer treatment and prolong the survival of patients with CRC.
These data suggest that inflammatory activity, in part mediated by TNFalpha, leads to perturbation of the endothelial glycocalyx in humans. This may contribute to the vascular vulnerability induced by inflammation.