Does overexpression of a stabilized mutant form of the cyclin-dependent kinase inhibitor p27 ( Kip1 ) inhibit cell growth?
These data are consistent with the hypothesis that the mutated form of p27(Kip1) is more effective in cell growth inhibition than the wild-type p27(Kip1) protein.
Taken together, our results suggest that Nrf2 may represent a strategic target for SCI therapies.