Do substrate properties influence calcification in valvular interstitial cell culture?
Collectively, VIC properties are highly linked to the culture microenvironment. Both, the biochemical and mechanical environment of tissue culture has an effect on the spontaneous calcification of VICs, and may also have a profound effect on their molecular properties, as related to an understanding of the disease process in vivo.
Because no differences were detected in costs but improvements were seen in clinical outcomes, the interventions offered in the WCDVS may be more efficient than usual care.