Does high-dose atorvastatin improve hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response?
Atorvastatin improves hypercholesterolemia-induced endothelial dysfunction without appreciable changes in collateral-dependent perfusion. Increased myocardial expression of endostatin, decreased expression of vascular endothelial growth factor, and chronic Akt activation associated with atorvastatin treatment may account for the diminished angiogenic response.
Pitavastatin effectively attenuated ischemia-induced leukocyte-endothelial interactions in the rat retina.