Is the Wnt/β catenin signalling pathway activated in Seminoma?
The results does not indicate the activation of the Wnt pathway, due to the lack of vimentin expression in 13/24 seminomas, the low expression in the rest of the cases, the lack of β-catenin in nuclei and the absence of CD1 and C-Myc expression. Further work is needed to confirm these observations and to test other signaling pathways in seminomas.
The CHR includes the vast majority of factor concentrate users and is therefore ideal as the basis for a national monitoring system.