Does genome-wide association study identify candidate genes for Parkinson 's disease in an Ashkenazi Jewish population?
We have demonstrated the utility of the AJ dataset in PD candidate gene and SNP discovery both by replication in dbGaP datasets with a larger sample size and by replicating association of previously identified PD susceptibility genes. Our GWAS study has identified candidate gene regions for PD that are implicated in neuronal signalling and the dopamine pathway.
Androgenesis and gynogenesis are unlikely to be causative in the cause of human early pregnancy loss, but germline mutations even in the presence of a normal karyotype could be influential.