Does histamine Receptor H1-Mediated Sensitization of TRPV1 mediate Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome?
In studies of rectal biopsy specimens from patients, we found that HRH1-mediated sensitization of TRPV1 is involved in IBS. Ebastine, an antagonist of HRH1, reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS. Inhibitors of this pathway might be developed as a new treatment approach for IBS. ClinicalTrials.gov no: NCT01144832.
Compared to earlier studies of similar design, we found that the level of preventive health care has improved during residency training, but remains unacceptably low.