Does th2 immune response play a critical role in the development of nickel-induced allergic contact dermatitis?
We confirmed the participation of Th2-type immune reactions in Ni-induced allergy using GATA-3 Tg mice.
Our results demonstrate that alendronate treatment opposes growth of orthotopic PC-3 tumors and decreases tumor metastasis to prostate-draining lymph nodes. This effect could be at least partly explained by decreased angiogenesis and increased apoptosis. The results suggest that bisphosphonates have anti-tumoral and anti-invasive effects on primary prostate cancer.