Does poly ( ADP-ribose ) polymerase inhibition reduce tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts?
PARP inhibition reduces the production of inflammatory mediators and the proliferation of RA FLS (in response to TNF), suggesting that PARP inhibitors could have therapeutic benefits in RA.
The VNTR polymorphism of the GPIbalpha gene, which affects the structure and function of this platelet glycoprotein, seems to be associated with risk for oral cancer, especially in patients without a family history of cancer.