Does inactivation of the FLCN tumor suppressor gene induce TFE3 transcriptional activity by increasing its nuclear localization?
Increased TFE3 activity is a downstream event induced by FLCN inactivation and is likely to be important for renal tumor development. This study provides an important novel mechanism for induction of TFE3 activity in addition to TFE3 overexpression resulting from Xp11.2 translocations, suggesting that TFE3 may be more broadly involved in tumorigenesis.
Dietary acidification is less effective than Ty in modulating the population dynamics of selected culturable populations of enteric bacteria.