Is interleukin-8 the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells?
In whole genome analysis of the epithelial response to H. pylori exposure, IL-8 demonstrated the most marked up-regulation, and was involved in many of the most important cellular response processes to the infection. There was dysregulation of apoptosis, tumor suppressor genes and oncogenes as early as in the first 24 h of H. pylori infection, which may represent early signs of gastric tumorigenesis. OMPLA⁺/⁻ did not affect the acute inflammatory response to H. pylori.
Depression status at angiography is associated with the need for revascularization and total healthcare costs for the following year.