Does dietary compound α-asarone alleviate ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages?
α-Asarone blocked 7β-hydroxycholesterol-induced macrophage apoptosis through allaying ER stress-specific signaling involving caspase activation and CHOP induction. α-Asarone was an anti-atherosclerotic agent antagonizing ER stress-mediated macrophage apoptosis by 7β-hydroxycholesterol.
In this first evaluation of the impact of SDB on cardiac readmissions in heart failure, CSA was an independent risk factor for 6 months' cardiac readmissions. The effect size of CSA exceeded that of all known predictors of heart failure readmissions.