Subgroup analyses in therapeutic cardiovascular clinical trials: are most of them misleading?
Subgroup analyses in recent cardiovascular RCTs were reported with several shortcomings, including a lack of prespecification and testing of a large number of subgroups without the use of the statistically appropriate test for interaction. Reporting of subgroup analysis needs to be substantially improved because emphasis on these secondary results may mislead treatment decisions.
Patients without previous surgery treated with RSA for fractures had better functional results than patients who had undergone previous surgery.