Does two-stage genome-wide association study identify integrin beta 5 as having potential role in bull fertility?
We have identified molecular markers associated with bull fertility and established that at least one of the genes harboring such variation has a role in fertility. The findings are important in understanding mechanisms of uncompensatory infertility in bulls, and in other male mammals. The findings set the stage for more hypothesis-driven research aimed at discovering the role of variation in the genome that affect fertility and that can be used to identify molecular mechanisms of development.
Higher- and lower-functioning adults with symptomatic knee OA appear to use different strategies when standing from a chair. Higher-functioning men flexed more at the hip and produced greater knee power than lower-functioning men. Higher-functioning women used less knee flexion than lower-functioning women. Since STS is an important mobility task, these parameters may serve as foci for rehabilitation aimed at reducing mobility limitations.