Is percutaneous transluminal angioplasty feasible and effective in patients on chronic dialysis with severe peripheral artery disease?
PTA is feasible and effective in dialysis patients with PAD, and should be preferred to other more invasive interventions.
The insulin secretory response was associated with the extent of ossification of the posterior longitudinal ligament. Since insulin receptor substrate-1 is expressed both in the spinal ligament and in the tissues regulating glucose metabolism, we speculate that some other molecules related to insulin signaling that are impaired only in the tissues regulating glucose metabolism may be responsible for the progression of ossification. We also speculate that the upregulation of insulin production due to the impairment of insulin action may stimulate osteoprogenitor cells in the ligament to induce ossification.