Is the nociception induced by glutamate in mice potentiated by protons released into the solution?
The nociception induced by glutamate is a useful method for investigation of the mechanisms of nociception and the effects of new analgesic drugs. Our findings showed that the protons released from glutamic acid have to be removed from the solution to avoid misinterpretation of results in the search for new analgesic drugs.
The ability to voluntarily activate back extensor muscles maximally does not appear to be impaired in subjects with a history of LBP during pain-free episodes.