Does chronotropic Incompetence Limit Exercise Capacity in Chronic Heart Failure?
The data refute the contention that CI contributes to impaired exercise capacity in CHF. This finding has widespread implications for pacemaker programming and the use of heart-rate lowering agents. (The Influence of Heart Rate Limitation on Exercise Tolerance in Pacemaker Patients [TREPPE]; NCT02247245).
These results suggest that serum IL-33 levels generally reflect increased inflammation in patients with psoriasis.