Is prolyl oligopeptidase inhibited in relapsing-remitting multiple sclerosis?
The decrease in circulating POP activity measured in MS is reverted by reductants. This suggests that POP inactivation in MS might be a result of the oxidative conditions prevailing in the plasma of the diseased patients. Plasma levels of POP activity as well as those of their endogenous inhibitor are suggested as biomarkers of inflammation and oxidative stress in MS.
These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension.