Is high glucose-induced intercellular adhesion molecule-1 ( ICAM-1 ) expression through an osmotic effect in rat mesangial cells PKC-NF-kappa B-dependent?
These results suggest that high glucose can upregulate intercellular adhesion molecule-1 protein and mRNA expression but not vascular adhesion molecule-1 expression in mesangial cells and promote leukocyte adhesion through up-regulation of intercellular adhesion molecule-1 through osmotic effect, possibly depending on the protein kinase C nuclear factor-kappa B (PKC-NF-kappa B) pathway. High glucose itself can also promote mesangial cell proliferation through the PKC-NF-kappa B pathways. We conclude that hyperglycaemia in itself seems to be an important factor in the development of early diabetic nephropathy.
Radical parotid surgery, which involves a great loss of quality of life for the patient, does not positively influence life expectancy. Moreover, the long-term prognosis is influenced by the type of the tumor and the stage at which the disease is first diagnosed.