Are prostaglandin metabolising enzymes and PGE2 inversely correlated with vitamin D receptor and 25 ( OH ) 2D3 in breast cancer?
The inverse correlation between VDR and both COX-2 and 15-PGDH, as well as between PGE(2) and 25(OH)(2)D(3) levels, suggests a possible link between VDR-associated target genes and prostaglandin metabolism.
The findings show that collecting such longitudinal data is possible, valuable and acceptable providing certain safeguards are in place.