Are prostasomes neuroendocrine-like vesicles in human semen?
The presence of synaptophysin has recently been shown in the serotonincontaining vesicles in platelets. A protein with a similar structure denoted granulophysin has been found in granulocytes and prostasomes. It is suggested that synaptophysin and granulophysin molecules are members of a family of proteins, maybe expressed in all cells that have regulated release of granule content. Our presented data indicate a neurotransmittor function of the prostasomes. The target cells are however not known but could be either the spermatozoa, the epithelial mucous cells of the uterus or tubas or perhaps the ovum.
The current results showed that GART expression was associated with glioma grade and that high GART protein expression might be related to poor outcome.