Do chREBP binding and histone modifications modulate hepatic expression of the Fasn gene in a metabolic syndrome rat model?
The results of this study indicate that expression of the Fasn gene in the livers of insulin-resistant rats is associated with increased H3K4 methylation, increased histone H3 acetylation, and increased H4 acetylation, and also, binding levels of ChREBP to promoter/enhancer region of Fasn gene is involved in the Fasn gene expression caused by hyperglycemia.
Although the sample size of women with POP studied is small, the present study shows that ERbeta gene haplotype may be associated with POP.