Are the common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients?
Hyperhomocysteinemia, serum folate levels and both C677T and A1298C MTHFR mutations are associated with CVD in HD patients.
The implementation of the European guidelines could imply a doubling of the numbers of Norwegian adults on cardiovascular medication for primary prevention. Contributors to the increase would be more frequent drug use in men and elderly people, particularly for LLD use.