Is depression in old age fatal only when people feel lonely?
The data suggest that the increased mortality risk attributable to depression in the presence of perceived loneliness may result from motivational depletion.
We conclude that the host response to ovarian carcinoma in this animal model recapitulates many aspects of the host response to bacterial sepsis especially concerning pituitary gene expression. These data suggest that, as in sepsis, a hypothalamic-hypophyseal-mediated cytokine response in ovarian carcinoma may result in hypermetabolism, accelerated nitrogen loss, anorexia, and cachexia.