Are life-threatening hemorrhage and prolonged wound healing remarkable phenotypes manifested by complete plasminogen activator inhibitor-1 deficiency in humans?
 Considering the results of the present study, the translation of mouse studies to humans must be performed with great care.
Around two thirds of patients treated with busulfan were outside the target AUC range after the first dose. Dose adjustment was made in 37% of patients. The relationship between CL and body weight was used to revise the initial IV dosing schedule. Sampling for AUC estimation could be reduced to 2 time points after IV dosing.