Are increased ALK gene copy number and amplification frequent in non-small cell lung cancer?
The study reveals a significant frequency of ALK amplification and its association with EGFR FISH positivity in lung adenocarcinomas. Based on these findings, a potential role of ALK amplification in the response to ALK inhibitors alone or combined with EGFR inhibitors in NSCLC merits further studies.
arBVMD can be caused by the compound heterozygous mutation L41P and I201T in the BEST1 gene.