Does selection of human anti-HIV broadly neutralizing antibodies occur within the context of frozen 1F7-idiotypic repertoire?
These results demonstrate that HIV-specific antibody responses are restricted within the 1F7 idiotype from early infection onwards, and that six well characterized BnAbs developed within the context of 1F7-idiotypic repertoire freeze. Future research should evaluate the necessity of the 1F7 idiotype for broad neutralization, and determine if vaccines should target Abs within or outside this idiotypic space.
These findings have important implications for developing interventions early in life to improve academic test scores and future opportunities available to children in this setting.