Are effects of early-life LiCl-pilocarpine-induced status epilepticus on memory and anxiety in adult rats associated with mossy fiber sprouting and elevated CSF S100B protein?
We showed that LiCl-pilocarpine-induced SE during development produced long-lasting behavioral abnormalities, which might be associated with mossy fiber sprouting and elevated CSF S100B levels at adulthood.
Our results confirm a role for FTO in responsiveness to hunger and satiety cues in adults in an experimental setting. The epistatic interaction suggests that DNA methylation, an epigenetic process, affects appetite.