Does poly ( adenosine diphosphate ribose ) polymerase inhibition modulate spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion?
Genetic deletion of PARP or inhibition of its activity (PJ34) rescued neurologic function in mice subjected to TAR. PARP inhibition might represent a novel therapeutic approach for prevention of SCI after TAR.
Despite very well-known risk of PAH in systemic sclerosis patients, the excessive increase of PAP during exercise is more commonly caused by left ventricular diastolic dysfunction than pulmonary arterial vasculopathy.