Are urinary interleukin-8 levels elevated in subjects with transitional cell carcinoma?
IL-8 levels were greater in subjects with TCC compared with those with successfully treated TCC. IL-8 levels increased with TCC stage, indicating that they are greater in more invasive (ie, angiogenic) tumors. A reduction in urinary IL-8 levels after treatment with bacille Calmette-Guérin or mitomycin C may reflect a decrease in bladder cancer cells and/or in other cells that produce IL-8.
During the year of this study, there were substantial temperature fluctuations but HbA1c concentration was more stable than FPG in non-diabetic individuals. It is therefore unlikely that temperature-related variation in HbA1c could affect the use of HbA1c as a diagnostic test for type 2 diabetes, but could affect the use of HbA1c as a glycemia control test for diabetes.