Does inhibition of inducible nitric oxide synthase ameliorate functional and histological changes of acute lung allograft rejection?
(1) iNOS expression and increased NO production occurred during the early stages of acute rejection, persisted throughout the unmodified rejection process, and localized to infiltrating inflammatory cells, but not allograft parenchymal cells; (2) aminoguanidine ameliorated the histological and functional changes of acute rejection; and (3) increased NO production, detected by the presence of iNOS mRNA, protein, or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection.
Phosphorus ylides might be valuable EPI compounds to reverse efflux related MDR in bacteria.