Is general anaesthesia better suitable than epidural anaesthesia for surgical removal of giant intraperitoneal tumours?
General anaesthesia under intubation and mechanical ventilation is better suited for surgical removal of giant intraperitoneal tumours.
These results suggest that activated fibroblastic status at the invading tumour front sets the stage for stromatogenesis and new blood vessel formation, facilitating deep transmural invasion in colorectal adenocarcinomas. This complicity of peritumorous fibroblasts in the overall aggressiveness/invasive and metastatic ability of colorectal tumours, occurring within the framework of cancer-stromal cell interactions, is probably favoured by the altered microenvironmental conditions of hypoxia and acidity.