Is cXCR4 overexpression associated with poor outcome in females diagnosed with stage IV non-small cell lung cancer?
CXCR4 is expressed in the majority of NSCLC tumors, and overexpression is associated with significantly poorer survival in stage IV NSCLC patients. Interestingly, this poor outcome is disproportionately represented in the female population. Our results suggest a gender-dependent difference in clinical outcome based on CXCR4 overexpression in stage IV NSCLC.
Tbx5 and Osr1 interact to regulate posterior SHF cell cycle progression for cardiac septation.