Does p38 MAPK regulate ischemia-reperfusion-induced recruitment of leukocytes in the colon?
We conclude that p38 MAPK regulates leukocyte rolling and adhesion in colonic I/R. Moreover, inhibition of p38 MAPK activity decreases formation of TNF-alpha and P-selectin-dependent leukocyte attachment to activated endothelial cells. Thus, our findings suggest that interference with the p38 MAPK signaling pathway could be an effective strategy to protect against I/R-induced inflammation in the colon.
Because of these results we put more emphasis on patient information to achieve the optimal result and to meet the individual needs for every patient.