Does unconjugated bilirubin inhibit proteolytic cleavage of von Willebrand factor by ADAMTS13 protease?
Unconjugated bilirubin directly inhibits ADAMTS13's ability to cleave both peptidyl and native VWF substrates in addition to its interference with certain fluorogenic assays. Our findings may help proper interpretation of ADAMTS13 results under pathological conditions. Whether elevated serum unconjugated bilirubin has prothrombotic effect in vivo remains to be determined in our future study.
CI failure as a result of anatomical abnormalities can be remedied by an ABI.