Does an Arf-GEF regulate antagonism between endocytosis and the cytoskeleton for Drosophila blastoderm development?
We propose that Steppke-dependent endocytosis keeps the cytoskeleton in check as early PM furrows form. Specifically, a cytohesin Arf-GEF-Arf G protein-AP-2 endocytic axis appears to antagonize Rho1 cytoskeletal pathways to restrain the membrane cytoskeleton. However, as furrows lengthen during cellularization, the cytoskeleton gains strength, blocks the endocytic inhibition, and finally closes off the base of each cell to form the blastoderm.
The clinical course, long-term outcome, and genetic mechanism of schwannomatosis differ from that of NF2.