Does mDR1a/1b gene silencing enhance drug sensitivity in rat fibroblast-like synoviocytes?
MDR1a/1b gene silencing by siRNA could effectively inhibit P-gp in rat FLS, resulting in a significant enhancement of the anti-inflammatory effects of DEX. The in vivo siRNA transduction could successfully silence MDR gene expression in the rat synovium. These findings indicate that the siRNA targeting MDR gene could be a useful tool for treating refractory arthritis in RA.
Differential S6 phosphorylation may have a role in abnormal keratinocyte proliferation/differentiation.