Does helper-dependent adenoviral gene therapy mediate long-term correction of the clotting defect in the canine hemophilia A model?
Although vector-associated toxicity remains an obstacle, a single injection of HDV led to long-term transgene expression and vector persistence in two FVIII-deficient animals with conversion of their severe phenotype to a moderate one.
No relationship was found between pre-operative CT measurements and peri-operative CAS measurements used to orient the femoral component. Data obtained from CT cannot be used peri-operatively with CAS to improve rotational setting of the femoral component.