Does niflumic Acid reduce Histamine-Induced MUC5AC Expression in Human Conjunctival Epithelial Cells?
Histamine-induced MUC5AC production could be decreased by niflumic acid, a calcium-activated chloride channel inhibitor.
CA2 expression is strongly regulated by intracellular pH and by cAMP, suggesting a role for soluble adenylyl cyclase. Regulation occurs in opposite directions which may be explained by an incoherent feedforward loop consisting of activation by pCREB and repression by ICER.