Do all men with pathological Gleason score 8-10 prostate cancer have poor outcomes?
In patients with high grade (Gleason score 8-10) prostate cancer after RP, the presence of either PSMs, ECE or SVI was associated with an increased risk of early BCR, with a 2-year BCR risk of ≥50%. Conversely, men with organ-confined margin-negative disease had a very low risk of early BCR despite Gleason score 8-10 disease.
Due to the low risk of progression, we believe that immediate eradication is not always necessary, thus reducing the adverse impact of repeat resections.