Is localisation of COX-2 protein different in breast ductal carcinoma and adjacent non-tumour ductal epithelium?
The non-tumour ductal epithelium adjacent to invasive ductal carcinoma shows a higher COX-2 expression than does the invasive ductal carcinoma. However, the different localisation of the immunohistochemically-detected protein suggests a possible post-translational regulation of the protein.
Altogether, our data strongly support a scenario in which microsporidia is the earliest-diverging clade of sequenced fungi.