Is an artificial sphincter the best choice for incontinent boys with Spina Bifida?
In our experience, the AS-800 model artificial sphincter has a long term survival which rarely exceeds 8 to 9 years putting into question whether it or bladder neck reconstruction is the best long term solution for treating children with neurogenic incontinence. This question may be only answered by a randomized, controlled trial comparing these two modalities.
The results indicate an Ang II-induced NO release in Af of mice, which is mediated by AT1-R. Thus, Ang II balances its own constrictor action in Af. This control mechanism is very important in view of high renin and angiotensin II concentration in the juxtaglomerular apparatus.