Does bMP-2 inhibit TF expression in human monocytes by shutting down MAPK signaling and AP-1 transcriptional activity?
BMP-2 can inhibit LPS-induced TF protein expression and surface presentation in human MNCs by downregulation of Erk1/2, p38, and JNK signaling, as well as reduced transcriptional activity of AP-1, but not NF-kB.
The serostatus of individuals migrating to low-prevalence countries as well as their sexual behaviour in the country of residence affect considerably the spread of HIV. Preventive measures should focus on targeted interventions, promoting safe sex practices, HIV testing, and entry to specialized HIV care among migrants.