Is diabetic nephropathy associated with increased urine excretion of proteases plasmin , prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells?
DN is associated with increased urinary excretion of plasmin, prostasin and urokinase and proteolytic activation of ENaC that might contribute to impaired renal Na(+) excretion and hypertension.
Routine histopathologic examination of specimens from patients undergoing hemorrhoid or anal fistula surgery is of value for identifying unexpected pathologic malignancy. An age older than 60 years may be a remarkable risk factor.