Are in women , no significant variances of calculated free testosterone ( cFT ) observed when a fixed value of albumin ( Alb : 4.3 g/dL ) is used instead of measured albumin values?
A fixed Alb of 4.3 g/dL is acceptable for most clinical evaluations. If Alb is ≤ 3.5 g/dL, along with SHBG ≤ 30 nmol/L, the variance increases and a free testosterone (FT) measurement by equilibrium dialysis is warranted for better accuracy.
We identify a novel protumorigenic PD-1(hi) B-cell subset in human HCC that exhibits a phenotype distinct from that of peripheral regulatory B cells. TLR4-mediated BCL6 upregulation is critical for induction of PD-1(hi) B cells, which operate via IL10-dependent pathways upon interacting with PD-L1 to cause T-cell dysfunction and foster disease progression. Cancer Discov; 6(5); 546-59. ©2016 AACR.See related commentary by Ren et al., p. 477This article is highlighted in the In This Issue feature, p. 461.