Is hypochlorous acid a potent inactivator of human plasminogen at concentrations secreted by activated granulocytes?
Since neutrophils have been shown to secrete HOCl/OCl(-) up to 100 micromol/L, inactivation of plasmin molecules by neutrophil-generated HOCl/OCl(-) could partly explain the increased thrombo-genicity observed in inflammatory conditions, in smokers and in other diseases. Thus, dietary intervention or the use of thiols or large doses of taurine compounds may be useful as coadjuvant therapeutic measures.
A common genetic variant of the BDNF gene is associated with increased risk of moderate-to-severe AR, and the AA genotype is associated with increased BDNF mRNA levels in peripheral blood. Together, these data indicate that functional BDNF gene variants increase the risk of moderate-to-severe AR.