Does reverse airflow in certain chest drain may be misinterpreted as prolonged air leakage?
During deep inspiration some patients are able to create negative pressure large enough to empty small water-seals in commercial chest drainage systems and retract air back into the chest tube. This excess air escapes during the following expiration and may mislead interpretation of continued air leakage even when there is none, subsequently resulting in prolonged and unnecessary chest tube drainage. Any surgeon who treats patients with chest tubes should be aware of this phenomenon.
These findings demonstrate that the exon-definition model explains alternative splicing of exon 11 in the IR gene in-vivo but not in-vitro. The in-vitro results suggest that the regulation occurs at a later step in spliceosome assembly on this exon.