Does mechano-growth factor E peptide inhibit the differentiation and mineralization of osteoblasts?
MGF-E could inhibit osteoblast differentiation and mineralization. The possible mechanisms are increased Erk activity and decreased Cbfα-1 nuclear translocation.
A clinical advantage of minimized over standard extracorporeal circulation was not found. Furthermore, a higher number of patients in the minimized extracorporeal circulation group required postoperative norepinephrine infusions for hemodynamic stabilization. In summary, the presumed superiority of minimized extracorporeal circulation for coronary artery bypass grafting in standard patients could not be confirmed.