Does iL-4 induce differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells?
The current study demonstrates that IL-4 induces differentiation of stem/precursor cells into fibroblast-like cells that demonstrate a more fibrogenic phenotype, which is due to reduced expression of miR-155. These findings provide a novel mechanism for the persistent abnormalities in IL-4-related diseases and a novel target to regulate tissue remodeling by fibroblasts.
Preischemic intracoronary mimosine infusion improves myocardial functional recovery after I/R.