Does histone deacetylase inhibitor suppress virus-induced proinflammatory responses and type 1 diabetes?
Microbial infections have been implicated in triggering type 1 diabetes in humans and animal models. The LEW1.WR1 rat develops inflammation and T1D following infection with Kilham rat virus. The histone deacetylase inhibitor ITF-2357 suppresses virus-induced inflammation and prevents diabetes. ITF-2357 prevents T1D without altering virus-specific adaptive immunity or virus clearance. ITF-2357 therapy may be an efficient approach to prevent T1D in genetically susceptible individuals.
The present findings suggest that latitude affects hyperthymic temperament, and ambient temperature might mediate this effect.