Does transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibit cytochrome P450 3A2 activity in male rats?
Topical application of antisense PMO in rats is a feasible delivery strategy for gene targets in liver and underlying skin.
The results of this study suggest that both spontaneous fluctuations and thigh cuff deflation techniques are able to provide reliable estimates of ARI, with the estimates from both spontaneous fluctuations and thigh cuff deflation techniques being in keeping with those reported elsewhere in the literature. dCA was impaired following AIS compared to controls when stroke subtype was considered. Importantly, no differences were observed between UA and AF. This has implications for the assessment of CA after stroke and reinforces the need to define a 'gold standard' test for the investigation of CA.