Does diosgenin induce ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells?
These results indicate that diosgenin obviously generates ROS and this oxidative pressure not only produces cytotoxic effect on CML cells but also induces autophagy. What's more, autophagy functions as a cytoprotective mechanism to overcome cytotoxicity of diosgenin in tumor cells and inhibition of autophagy can enhance the anti-CML activity of diosgenin.
A caring gastroenterologist trying to optimize his/her patient's well-being should try to assess the potential influence of truth on the patient's psyche and dispense it accordingly.