Does high dose of caffeine administered to pregnant rats cause histopathological changes in the cornea of newborn pups?
Excessive gestational caffeine intake has been shown histopathologically to have some teratogenic effects on newborn rat cornea.
Coadministration of desloratadine and ketoconazole was well tolerated and was associated with minimal increase in AUC and C(max). The combination did not induce any clinically relevant electrocardiographic changes.