Is a higher radiotherapy dose associated with more durable palliation and longer survival in patients with metastatic melanoma?
RT was found to provide effective palliation of non-CNS metastasis from malignant melanoma and should be considered for symptomatic patients. RT doses >30 Gy and a BED >39.0 Gy(10) were found to be associated with longer palliation.
We can hypothesize that CD10 positive neoplasia display a more invasive behaviour, independently from the N score and the G score, compared to CD10 negative neoplasia.