Do atrial and C-type natriuretic peptides amplify growth factor activity in primary aortic smooth muscle cells?
ANP enhances the mitogenic effect of FGF-2, via a mechanism that may involve elevation of immediate early gene expression but not enhancement of FGF receptor protein levels. We speculate that ANP and CNP released from macrophages and endothelial cells could enhance the mitogenic effect of FGF-2 or EGF in vivo.
MiR-378 transfection could effectively promote MSCs survival and vascularization under hypoxic-ischemic condition in vitro.