Is hydrogen peroxide-mediated induction of SOD1 gene transcription independent from Nrf2 in a cellular model of neurodegeneration?
Although our data suggest that SOD1 is transcriptionally regulated in response to OS, Nrf2 does not appear to associate with SOD1 promoter in this cellular model of neurodegeneration. Our results open new perspectives in the comprehension of two key antioxidant pathways involved in neurodegenerative disorders.
UI equally impacts the functional and psychological QOL in women regardless of age. UI in women<55 results in a greater negative impact on level of physical activity, whereas women<45 are significantly more frustrated.