Do circular antisense oligonucleotides inhibit growth of chronic myeloid leukemia cells?
Circular oligodeoxyribonucleotides (1) inhibit the accumulation of CML cells, (2) decrease the amount of bcr-abl protein per cell, (3) have sequence-selective activity, and (4) are more active than linear oligonucleotides containing only the base-pairing region.
We found no association between having a student-run clinic in 2005 at a medical school and proportion of its graduates who currently practice primary care. Since there are considerable limitations of an institution-based study, it may be useful to study specialty choice for individual students who participate in student-run clinics, given that prior research has shown longitudinal educational experience with underserved population is associated with increased likelihood of choosing primary care careers.