Does aMP-activated protein kinase regulate GLUT4 transcription by phosphorylating histone deacetylase 5?
These data reveal a signal transduction pathway linking cellular energy charge to gene transcription directed at restoring cellular and whole-body energy balance and provide new therapeutic targets for the treatment and management of insulin resistance and type 2 diabetes.
LUSI in patients with early-stage endometrioid endometrial cancer is associated with decreased survival.