Is claudin-7 down-regulation an important feature in oral squamous cell carcinoma?
Loss of claudin-7 expression is associated with important subcellular processes in OSCC with impact on clinical parameters.
PAI-1 is significantly downregulated in PASMC in IPAH, on the mRNA and protein level. PAI-1 negatively regulates PASMC proliferation, while it increases PASMC migration. Thus, its loss in IPAH may therefore contribute to pathologic vascular remodelling in IPAH.