Does valproate suppress status epilepticus induced by 4-aminopyridine in CA1 hippocampus region?
We conclude that 4-AP-induced SE was suppressed by VPA at 400-600 mg/kg, whereas minor doses (100-300 mg/kg) only prevent the 4-AP-induced SE. Present results suggest the revisiting of VPA as a useful drug for the treatment of SE.
The newly proposed methodologies provide improved results compared to the previous study. The hierarchical framework is suggested for diagnostic classification of pulmonary sounds, although the algorithms are still open for further improvements.