Does the suppression of bromodomain and extra-terminal domain inhibit vascular inflammation by blocking NF-κB and MAPK activation?
BET bromodomain is important for regulating endothelial inflammation. Strategies targeting endothelial BET bromodomain may provide a new therapeutic approach for controlling inflammatory-related diseases.
Obesity is prevalent in this breast cancer population. BSA is not a sensitive index of large body size. We consistently detected more frequent empiric dose reductions at cycle one of adjuvant chemotherapy, with reductions of greater magnitude in the largest women (BSA>or = 2 m2) and those who were overweight (BMI>or = 25 kg/m2).