Do frequency of Acentric Fragments Are Associated with Cancer Risk in Subjects Exposed to Ionizing Radiation?
AFs are associated with cancer risk and have a similar sensitivity to dicentric chromosomes in subjects exposed to IR. Because automated AF scoring can be easily introduced using fast flow cytometry combined with the pan-centromere staining, this biomarker may hold promise as a potential sensitive biomarker of exposure to IR and cancer risk.
Our observation supports the hypothesis that ozone in healthy children is associated with eosinophil inflammation, most likely in the airways.