Does aldose reductase-mediated phosphorylation of p53 lead to mitochondrial dysfunction and damage in diabetic platelets?
Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53. The degree of mitochondrial dysfunction and damage determines whether hyperactivity (mild damage) or apoptosis (severe damage) will ensue. These signaling components provide novel therapeutic targets for thrombotic complications in diabetes mellitus.
This study provides preliminary evidence of a genetic association between IL1B and IL17A genes and RLS.