Anal sphincter fatigue: is the mechanism peripheral or central?
AS exhibits a greater decline in voluntary activation during fatiguing contractions than elbow flexor muscles. This is not accompanied by peripheral changes, which implies central mechanisms are responsible. Thus, we conclude that AS is susceptible to central fatigue during maximal voluntary activations. We propose this may be a protective mechanism to conserve contractile potential of the anal sphincter for function.
This study demonstrates that the presence of septic AKI varies significantly based on the site of infection but not the type of causative organism.