Is frequent mutation in the ABCC6 gene ( R1141X ) associated with a strong increase in the prevalence of coronary artery disease?
The presence of the R1141X mutation in the ABCC6 gene is associated with a sharply increased risk of premature CAD.
National mortality statistics strongly underestimate the number of deaths associated with HF. Moreover, the high mortality rate in HF patients amounts to a remarkably large number of life years lost given the advanced age of disease onset.