Does insulin-stimulated glucose transport inhibit Ca2+ influx and contraction in vascular smooth muscle?
Since the effects of insulin on serotonin-stimulated Ca2+ transport, intracellular Ca2+ concentration, and contraction were dependent on glucose transport and were duplicated when glucose transport was stimulated by high extracellular glucose concentration rather than insulin per se, it is concluded that insulin-stimulated glucose transport is an early event that leads to decreased Ca2+ influx and contraction in vascular smooth muscle.
Epistemologically, the use of inconsistent language among texts and educators may be playing a role in the continuing marginalization of theory, research and reasoning in nursing education and practice; ultimately, hindering the profession's epistemological growth. Recommendations include a call for consensus of key words and meanings associated with theory, research and reasoning and the development of a language essentials document to support development of competency.