Does chronic oxaliplatin resistance induce epithelial-to-mesenchymal transition in colorectal cancer cell lines?
We hypothesize that induction of EMT may contribute to the decreased efficacy of therapy in chemoresistant CRC, as the tumor cells switch from a proliferative to invasive phenotype. Further understanding of the mechanisms of chemoresistance in CRC will enable improvements in chemotherapy for metastatic disease.
We failed to elicit positive correlation between elevated SPC levels and postoperative infection in cardio surgical patients.