Is antiapoptotic protein Bcl-x ( L ) up-regulated during megakaryocytic differentiation of CD34 ( + ) progenitors but is absent from senescent megakaryocytes?
Although little is known regarding the functional significance of survival proteins within the megakaryocytic compartment, the changes in the Bcl-x(L) expression pattern observed in UT7 and CD41(+) cells may play a role in the survival of developing megakaryocytes and the lifespan of mature platelets.
Collectively, these data demonstrate that adiponectin has the molecular potential to inhibit the oncogenic actions of leptin by blocking downstream effector molecules.