Does sural sparing pattern discriminate Guillain-Barré syndrome from its mimics?
Common electrodiagnostic abnormalities in early demyelinating GBS do not usually exclude other rare differential diagnoses. An exception to this is the sural sparing pattern described here, which strongly supports the diagnosis of demyelinating GBS.
In this model of progressive central hypovolemia secondary to application of LBNP in humans, radial pulse character score decreased in concert and was highly correlated with decreases in SBP. In support of our hypothesis, changes in pulse character, SBP, and mental status occurred only after significant reductions in SV, suggesting that these standard vital signs may not be early indicators of central hypovolemia.