Does neoadjuvant Systemic Therapy Before Radical Prostatectomy in High-Risk Prostate Cancer Increase Surgical Morbidity : Contemporary Results Using the Clavien System?
The use of neoadjuvant systemic therapy did not appear to increase the risk of perioperative complications. These findings support current clinical trials, which might elucidate the oncologic benefit of this multimodality approach.
In view of our observation that ER beta but not ER alpha is expressed regularly in normal human synovia in high amounts, we propose that estrogen could play a significant role in synovial membrane function in women and men, operating preferably via the ER beta isoform.