Does human monocyte-endothelial cell interaction induce platelet-derived growth factor expression?
These results indicate that the direct cell-to-cell interaction between human monocytes and ECs induces PDGF synthesis in both types of cells, suggesting that PDGF produced locally by monocyte-EC adhesive interaction plays an important role in the pathogenesis of atherosclerosis by promoting the migration and accumulation of vascular smooth muscle cells.
Sildenafil prevents myocardial remodelling in pulmonary hypertension through an indirect action via right-ventricular unloading.