Are inactive or moderately active human promoters enriched for inter-individual epialleles?
Our work identifies potential key features of epiallelic variation in humans, including temporal stability of non-genetically determined epialleles, and concomitant perturbations of chromatin state. Furthermore, our work suggests a novel mechanistic link among inter-individual epialleles observed in the context of normal variation, cancer and ageing.
Our results indicate that high level of circulating VEGF predicts poor OS in lung cancer, yet it does not predict poor PFS.