Does heat shock protein 90 ( Hsp90 ) inhibition target canonical TGF-β signalling to prevent fibrosis?
Hsp90 is upregulated in SSc and is critical for TGF-β signalling. Pharmacological inhibition of Hsp90 effectively blocks the profibrotic effects of TGF-β in cultured fibroblasts and in different preclinical models of SSc. These results have translational implications, as several Hsp90 inhibitors are in clinical trials for other indications.
The pharmacokinetics of olanzapine are similar in both Chinese and Caucasian racial groups.