Are notch-induced transcription factors predictive of survival and 5-fluorouracil response in colorectal cancer patients?
The present study is the first to discover that HEY1 overexpression correlates with poorer outcome in CRC, and NTF expression is predictive of CRC patient survival with 5-FU chemotherapy. If confirmed in future studies, testing of NTF expression has the potential to enter routine pathological practice for the selection of patients to undergo chemotherapy alone or in combination with Notch inhibitors.
PON1 gene polymorphisms may influence the features of Japanese patients with OAG.