Is brain penetration of the OAB drug trospium chloride increased in aged mice?
Based on our in vivo data in a mouse model, we conclude that trospium chloride permeation across the BBB is not increased in ageing per se, and therefore, the occurrence of adverse CNS drug effects is also not expected to increase with ageing.
Though rare before PVI, new esophageal LGE is seen in almost one-third of patients after PVI. The clinical implications to remain to be explored, but clinicians should be aware of this frequent imaging finding.