Do cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells?
These results demonstrate the utility of human ES cell to evaluate specific stimuli that regulate cell fate decisions and the survival of specific lineages. Moreover, the method used to promote differentiation of ES cells may alter the cytokines or growth factors required to isolate specific cell types.
The PIAS1 results in particular may represent a basis for new approaches for efficiently distinguishing adenomas from colon cancer.