Does alendronate interfere with 99mTc-methylene diphosphonate bone scanning?
Alendronate did not competitively inhibit uptake of 99mTc-MDP in the skeleton or tumor metastasis. Use of alendronate before bone scanning is unlikely to result in decreased detection of lesions or falsely decreased 99mTc-MDP activity at metastatic bone tumor sites.
The study did not include a depressed patient group, which restricted our ability to interpret the observed group differences.