Does in vitro Anti-Urolithiasis potentials of Argemone mexicana L. leave?
The extracts were tested the percentage inhibition of anti-urolithiasis potentials against preformed calcium oxalate crystal. The results of A. mexicana extracts on nucleation assay were found to be significant and the methanol leaf extract showed considerable inhibition (72.26 %) compared to standard cystone drug (62.96%) and in aggregation assay also the methanol leaf extract of A.mexicana showed significant inhibition (77.24 %) compared to cystone (69.33 %) at 100 mg/ml concentration. The microscopic assay clearly indicated that A. mexicana leaves extracts capable to dissolve the calcium oxalate crystals.
The present results suggest that caspase-3 activation is required for delayed paraplegia and motor neuron degeneration after spinal cord ischemia.