Does genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicate several CYP2B6 variants?
Three CYP2B6 polymorphisms were independently associated with efavirenz estimated Cmin at genome-wide significance, and explained one-third of interindividual variability. These data will inform continued efforts to translate pharmacogenomic knowledge into optimal efavirenz utilization.
Only 1 endoscopist performed endoscopic procedures, and interobserver agreement could not be assessed.