Does renal-targeting triptolide-glucosamine conjugate exhibit lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats?
The renal-targeting TPG is more effective and less toxic than TP, in amelioration of I/R-induced rat renal injury, which may provide a new avenue for the treatment of acute kidney injury.
Our study suggests for the first time that higher PDCD4 expression might play an important role in PCOS pathogenesis by affecting obesity, insulin resistance, lipid metabolism disorders, and GC apoptosis.