Does valproic acid protect against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model?
Changes in GSK3β-Ser(9) phosphorylation in in vivo haemorrhagic shock models can be modelled in vitro, and this has identified a role for PPARγ activation in the protective role of VPA.
Given the rarity of pediatric stroke, future studies will require multicenter efforts and possibly a national surveillance system.