Do extra-embryonic endoderm cells derived from ES cells induced by GATA factors acquire the character of XEN cells?
We show here that Gata-induced extra-embryonic endoderm cells derived from ES cells mimic the character of XEN cells. These findings indicate that Gata transcription factors are sufficient for the derivation and propagation of XEN-like extra-embryonic endoderm cells from ES cells.
These immortal OSE cell lines are likely to be an important tool for studying human OSE biology and carcinogenesis.