Do n-methyl D-aspartate channels link ammonia and epithelial cell death mechanisms in Helicobacter pylori Infection?
A/A affects gastric epithelial cell viability by allowing excessive Ca(2+) permeation through NMDA channels. NMDA channels might thereby regulate cell survival and death pathways during development of gastric cancers associated with H pylori infection.
Replication of a mutation previously implicated in other populations suggests a role for the MSX1 A34G variant in the development of CL(P).