Are discrepancies between FISH and immunohistochemistry for assessment of the ALK status associated with ALK 'borderline'-positive rearrangements or a high copy number : a potential major issue for anti-ALK therapeutic strategies?
The discrepancies observed between the IHC and FISH data revealed unexpected biological events, rather than technical issues, which potentially can have a strong impact on the therapeutic strategy with crizotinib.
The study supports the hypothesis that nurses' aides who were exposed to ETS at home during childhood have an increased risk of long-term sickness absence.