Does phosphorylation of the MBF repressor Yox1p by the DNA replication checkpoint keep the G1/S cell-cycle transcriptional program active?
This study shows that checkpoint-dependent phosphorylation of Yox1p at Ser114, Thr115 results in de-repression of the MBF transcriptional program. The remodeling of the cell cycle transcriptional program by the DNA replication checkpoint is likely to comprise an important mechanism for the avoidance of genomic instability.
All children made a full recovery without surgical morbidity. However, none of these cases fulfilled the recommended criteria for laparotomy in children with blunt abdominal trauma and splenectomy may have been avoidable.