Is lymphocytic alveolitis associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects?
These findings suggest that alveolitis associated with HIV-1 infection is caused by the recruitment of HIV-1-specific CD4(+) and CD8(+) T cells to the lung. These antigen-specific T cells display an impaired proliferative capacity that is caused by increased expression of PD-1.
The efficacy of kappa opioids appears to be affected by animal sex, an effect that can be contributed to by both oestradiol and testosterone.