Does exposure to thrombus diminish endothelial derived relaxation in the rabbit carotid artery?
The presence of thrombus within the rabbit carotid artery for a period of 4 h decreases endothelial-dependent relaxation. Four hours of endothelial ischemia without thrombus did not change endothelial-dependent vasorelaxation. Neither thrombus nor ischemia alone had any effect on the endothelium-independent vasorelaxation. We conclude that thrombus is deleterious to endothelial function independent of smooth muscle function in the acute setting as measured by endothelial-dependent vasorelaxation.
Preoperative administration of parecoxib for postoperative analgesia provided significant effect on reducing PACU length of stay (LOS) and discharge time, and improving patient outcome after ambulatory LC.