Does igG2 anti-Galalpha1-3Gal induce porcine aortic endothelial cell accommodation in vitro?
Using primary PAEC monolayers, we were unable to induce resistance to CDC with human normal immunoglobulin and its IgG2 anti-Gabeta1-3Gal subset. This contradicts previous experiments using trypsinized, immortalized cells. Although resistance to CDC is not an ideal marker of accommodation, the detrimental effects of IgG make it unlikely that it will become a useful clinical means of inducing accommodation.
We conclude that glutamine or zinc protects against malnutrition-induced brain developmental impairments.