Does na-Ca exchange tail current indicate voltage dependence of the Cai transient in rabbit ventricular myocytes?
The results of this study suggest that in cells dialyzed with 10 mM Na, the voltage dependence of the Cai transient is different from the L-type Ca current, since this current declines at potentials > +20 mV. The results obtained using Fura-2 suggest that the INa-Ca tail current measurement tracked the Cai sufficiently well to reflect the voltage dependence of the Cai transient. The data also confirm that the voltage dependence of the Cai transient in rabbit cells can be modulated by altering dialyzing Na concentration.
Underdiagnosis and undertreatment of childhood asthma still seem to be a major problem in the management of childhood asthma, especially in preschool children, even after the recommendations of guidelines.