Does extracellular Matrix of Current Biological Scaffolds promote the Differentiation Potential of Mesenchymal Stem Cells?
Differences in the extracellular matrix composition of scaffolds significantly impact their potential to promote differentiation of bMSCs. Comparing the native RCT to the tested scaffolds showed that a high content of type I and III collagen significantly increased the potential of bMSCs to differentiate toward bone, tendon, fat, and cartilage lineages.
Altogether, these results support a role for MBH DEPTOR in the regulation of energy balance and metabolism.