Does raloxifene inhibit menin-dependent estrogen receptor activation in breast cancer cells?
Raloxifene inhibits the binding of menin to the AF-2 domain of ERα, suggesting that raloxifene is one of the therapeutic options for menin-positive breast cancer.
Perioperative complications after adolescent scoliosis fusion surgery are more frequent in lower volume settings. This may reflect a learning curve required for more complex cases as the trends are magnified in neuromuscular/congenital scoliosis cases or simply that higher volume surgeons are more adept at these fusions. The impact of volume on reduced length of stay and hospital charges has implications for future health care economics measures.