Does inhibition of matrix metalloproteinases reduce local and distant organ injury following experimental acute pancreatitis?
Pancreatitis results in increased local and distant MMP activity. Pulmonary and pancreatic injury following AP can be abrogated by treatment with an MMP inhibitor (Batimistat; BB-94) which may result in decreased morbidity and mortality.
We believe this represents a previously unreported hereditary syndrome.