Is reduced interferon gamma production by antigen-stimulated cord blood mononuclear cells a risk factor of allergic disorders -- 6-year follow-up study?
Reduced IFN-gamma production by antigen-stimulated CBMCs is a risk factor of allergic disorders.
ESCC and EAC share similarly high frequencies of overall and clinically relevant genomic alterations; however, the profiles of genomic alterations in the two diseases differ widely, with KRAS and ERBB2 far more frequently altered in EAC compared with ESCC and with mammalian target of rapamycin (MTOR) pathway genes (PIK3CA and PTEN) and NOTCH1 more frequently altered in ESCC compared with EAC. Comprehensive genomic profiling highlights the promise of identifying clinically relevant genomic alterations in both ESCC and EAC and suggests new avenues for molecularly directed therapies in esophageal cancer.