Does endogenous adrenomedullin protect against vascular response to injury in mice?
The overproduction of oxidative stress induced by the increased NAD(P)H oxidase activity might be involved in cuff-injured arterial intimal hyperplasia in AM+/- mice. Thus, it is suggested that endogenous AM possesses a protective action against the vascular response to injury, possibly through the inhibition of oxidative stress production.
Significant interobserver differences in prostate volume defined on postimplant CT scans were observed. These differences led to significant differences in commonly used dosimetric quantifiers according to the individual reviewer. Until a greater degree of agreement among reviewers can be established, inferences concerning postimplant CT-based dosimetric analysis will be problematic at best. Additional efforts to increase interobserver agreement are required.