Does bevacizumab-induced tumor vessel remodeling in rhabdomyosarcoma xenografts increase the effectiveness of adjuvant ionizing radiation?
Our findings support the hypothesis that VEGF inhibition with bevacizumab transiently normalizes the dysfunctional vasculature of RMS xenografts, improving tumor oxygenation and increasing tumor sensitivity to adjuvant IR.
These prospective results do not support the hypothesis that statin drugs protect against prostate cancer in the setting of regular prostate cancer screening.