Does genetic analysis of inflammatory bowel disease in a large European cohort support linkage to chromosomes 12 and 16?
These data are consistent with linkage of IBD to chromosomes 12 and 16. The replication of genetic risk loci in a large independent family collection indicates important and common susceptibility genes in these regions and will facilitate identification of genes involved in IBD.
DBS of the SNr/STN may be an effective treatment option for patients with PME. Less impaired patients may benefit more markedly.