Does selective inhibition of FAAH produce antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides?
These data expand our understanding of the ECS function and provide a novel framework for the development of future potential treatments of functional GI disorders.
Baclofen should be avoided in uremic patients. When consciousness disturbance occurs in uremic patients, baclofen-associated neurotoxicity should be included in the list of differential diagnosis. According to experiences of our patients, we conclude that neither early nor routine hemodialysis is more effective than CAPD in shortening the recovery time of baclofen-associated neurotoxicity.