Polygenic risk scores for smoking: predictors for alcohol and cannabis use?
Smoking, alcohol and cannabis use are influenced by aggregated genetic risk factors shared between these substances. The many common genetic variants each have a very small individual effect size.
Our study demonstrates that ICR specifically regulates CSC properties of ICAM-1(+)HCC cells and that ICR contributes to PVTT development. Therefore, ICR may be a promising target for HCC therapy.