Are patients with limb and head tremor a clinically distinct subtype of essential tremor?
Several demographic and clinical variables suggest that ET patients with HT have a distinct clinical phenotype.
The severer impairment of cortical GABAergic neurons in alkalosis patients leads to more critical neural excitotoxicity, so that alkalosis-induced brain dysfunction is difficultly corrected, compared to acidosis. The vulnerability of cortical GABAergic neurons to high pH is likely a basis of severe clinical outcomes in alkalosis versus acidosis.