Does activation of the peroxisome proliferator-activated receptor γ counteract sepsis-induced T cell cytotoxicity toward alloantigenic target cells?
In the sepsis CLP mouse model, CTLs are activated toward alloantigenic target cells. Sepsis-mediated alloantigenic CTL activation is blocked in vivo by PPARγ activation. PPARγ deletion or antagonization restored rosiglitazone-dependent inhibition of CTL cytotoxicity. PPARγ inhibits the expression of Fas and granzyme B in CTLs.
Subjects can adapt to TR by repeated exposure. At the same time, susceptibility to HN increases. Strategies for pre-adaptation to space motion sickness need to be chosen carefully as they could actually be counterproductive.