Does lifelong treatment with oral DHEA sulfate preserve immune function , prevent disease , or improve survival in genetically heterogeneous mice?
Although differences among species in pharmacokinetics complicate interpretation of studies in which DHEA or DHEAS is administered to rodents, our data provide no support for the idea that chronic exposure to this steroid retards immune senescence or prevents late life illness.
A spontaneous acrosome reaction does not necessarily predispose a spermatozoon to fuse with the oocyte after SUZI. It remains to be elucidated whether this relative inefficiency of acrosome-reacted spermatozoa is related to technical aspects of SUZI or whether, in a more general sense, the acrosomal exocytosis and the development of sperm-oocyte fusion capacity are distinctly regulated, though closely related, phenomena.