Does completion of cytokinesis in C. elegans require a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex?
We have shown that BFA disrupts the terminal phase of cytokinesis in the embryonic blastomeres of C. elegans. We observed that membrane accumulates at the apices of the late cleavage furrow by means of a BFA-sensitive mechanism. We suggest that this local membrane accumulation is necessary for the completion of cytokinesis and speculate that the spindle midzone region of animal cells is functionally equivalent to the phragmoplast of plants and acts to target secretion to the equatorial plane of a cleaving cell.
Serum VAP-1 predicts mortality independently and improves risk stratification in CRC subjects.