Urinary tract infection during pregnancy: a risk factor for cerebral palsy?
Urinary tract infection during pregnancy was found to be a risk factor for development of cerebral palsy in offspring. Assessment for UTI should occur at the initial prenatal visit and more frequently for women with symptoms or who are at risk. Pregnant women should be educated about preventive measures for UTI. Future research is needed to assess more directly the relationship between UTI during pregnancy and cerebral palsy in offspring.
Our results identify a novel outcome of Th17 plasticity in humans that may account for the enrichment of GM-CSF-expressing T cells in the joints of patients with JIA. The association of GM-CSF expression with systemic inflammation highlights the potential role of Th17-related cytokines in the pathology of JIA.