Is [ Polyglutamine-expanded ataxin-3 degraded by autophagy ]?
The data suggested that autophagy is involved in the degradation of mutant ataxin-3, resulting in a decrease in the proportions of aggregate-containing cells and cell death in HEK293 cells expressing polyglutamine-expanded ataxin-3. It is possible that autophagy may be applied as a potential therapeutic approach for SCA3/MJD.
Distortions of agency constitute a core feature of the disease that is already present in the PP but may evolve further with progression of the illness. Distortions of agency may thus represent a promising additional predictive risk factor for transition to psychosis in PP patients.