Does the orexin antagonist SB-649868 promote and maintains sleep in men with primary insomnia?
The data demonstrate the sleep-promoting properties of the orexin antagonist SB-649868 in male patients with insomnia.
Increased expression of eIF-2alpha took place in both benign and malignant neoplasms of melanocytes and colonic epithelium. These findings suggest that elevated expression of this translation initiation factor may contribute to tumor initiation and progression but that it is not sufficient for establishing a malignant phenotype in the tumors analyzed in this study.