Is apoptosis induction and growth suppression by U19/Eaf2 mediated through its ELL-binding domain?
These observations argue that the interaction with ELL is essential for the induction of apoptosis and growth suppression by U19/Eaf2.
In our study immunogenic proteins were extracted from SS and SI fractions and OMPs were similar to those reported in other pathogenic Leptospira strains. These OMPs being unique to all the pathogenic leptospires, can be targeted for diagnostic purpose. Further analysis of the cellular location and expression of leptospiral proteins will be useful in the annotation of genomic sequence data and in providing insight into the biology of Leptospira cells.