Do sphingomyelinase-induced ceramide production stimulate calcium-independent JNK and PP2A activation following cerebral ischemia?
Cerebral ischemia up-regulates the sphingomyelin-ceramide pathway, which involves calcium-independent JNK and PP2A activation in hippocampal glia; this may play a significant role in cerebral lesions post-ischemia.
We found no evidence that BMD loss, as detected during routine clinical monitoring, was a significant independent risk factor for major osteoporotic fractures.