Do mammalian conserved ADAR targets comprise only a small fragment of the human editosome?
Despite the discovery of numerous editing targets, only a small number of them are conserved within mammalian evolution. These sites are extremely highly conserved and exhibit unique features, such as tight regulation, and probably play a pivotal role in mammalian biology.
Results suggest that genetic variations in the C/EBP-delta might play a role in some metabolic phenotypes.