Does inhibition of CXCR4 activity with AMD3100 decrease invasion of human colorectal cancer cells in vitro?
The CXCL12/CXCR4 system is an important mediator of proliferation and invasion of CXCR4-expressing colorectal cancer cells. AMD3100 inhibited invasion and metastasis activity of the colorectal cancer cell line SW480 through down-regulation of VEGF and MMP-9 expression.
Findings suggest that high altitude may increase the risk of BPD development among preterm infants.