Does fasting hyperglycemia impair glucose- but not insulin-mediated suppression of glucagon secretion?
Insulin-mediated suppression of glucagon secretion is unrelated to the fasting plasma glucose concentration and is not impaired by chronic hyperglycemia. Thus, the defect in plasma glucagon suppression during the OGTT most likely results from impaired glucose-mediated glucagon suppression. The close correlation between fasting plasma glucose concentration and reduced glucagon suppression suggests a glucotoxic effect on alpha-cell function.
HSF1 can inhibit heat stress-induced apoptosis in Raw264.7 macrophages.