Is the up-regulation of monocyte chemoattractant protein-1 ( MCP-1 ) in Ea.hy 926 endothelial cells under long-term low folate stress mediated by the p38 MAPK pathway?
During long-term folate stress, p38 is the primary determinant of CCL2 transcription. Long-term folate insufficiency "primes" Ea.hy 926 endothelial cells to have a quantitatively more vigorous response to cytokine-mediated inflammatory stress.
Anemia was frequent among RTRs displaying microalbuminuria, which may reflect EPO deficiency due to the tubulointerstitial injury of chronic allograft nephropathy. The EPO deficiency may begin before significant deterioration in excretory function of the kidney.