Does nitric oxide inhibit a rise of ATP-introduced cytosolic free Ca2+ concentration and release from intracellular stored Ca2+?
The ATP induced [Ca2+]i rise that release Ca2+ from both Insp3 and ryanochine receptors and Ca2+ entry through calcium channels. The inhibition of NO on ATP induced [Ca2+]i rise that was mediated by cGMP.
These data suggest that there is a high serum level of E-selectin in psoriatic subjects even after clearing of the disease. Serum E-selectin may reflect the general activation of endothelial cells in the disease and may be a new sensitive marker of disease activity.