Does infliximab partially impair the anti-Mycobacterium tuberculosis immune responses of severe psoriasis patients with positive tuberculin skin-test?
Infliximab affected some, but not all aspects of the in vitro antituberculosis immune responses tested. The preserved effector-memory responses, putatively related to exposure to environmental mycobacteria, may help to explain the lower than expected susceptibility to tuberculosis reactivation in our setting.
Our findings are in accord with the concept that LMN degeneration in ALS is related to local factors in the spinal cord.