Do an update on using vitamin E in Alzheimer 's disease?
Supplementation of AD patients with vitamin E increases its levels in biological fluids and decreases their susceptibility to oxidative stress. However, clinical interventional and observational studies demonstrated contradicting results regarding the benefit of vitamin E in AD. Available data do not provide any clear evidence that vitamin E beneficially influences AD and are not sufficient to recommend vitamin E for primary or secondary prevention of AD. The future of vitamin E supplementation in AD should be therefore regarded with caution.
Activation of hypoxia pathways is an intrinsic self-regulated process, independent of Hb levels in endometrial adenocarcinomas. Other factors such as microvessel density (MVD), vessel/tumor cell distance or genetic events may be important.