Is somatosensory processing impaired in temporal lobe epilepsy?
Patients with medically intractable TLE have impaired tactile GrOr discrimination bilaterally that is not due to nonspecific effects of AEDs. This impaired perceptual ability may be reversible with surgical removal of the seizure focus.
This study shows that in the early lesions of experimental OA cartilage in situ, activation of the caspase cascade is responsible for induction of chondrocyte death. Marked inhibition of cell death by caspase inhibitors indicates a significant participation of apoptosis in the phenomenon. This phenomenon is linked to the activation of at least 2 major kinase pathways, MEK 1/2 and p38. These pathways are responsible for upregulating the expression of iNOS and COX-2, each of which seems essential for the induction of apoptosis. Data are provided about possible regulation and interregulation of the COX-2 and iNOS systems by prostaglandin E2 and NO.