Does p27 ( Kip1 ) inhibit systemic autoimmunity through the control of Treg cell activity and differentiation?
Our results point to p27 as a critical regulator of Treg cell differentiation and function through the positive modulation of TGFβ signaling strength in T cells.
The results show that APOE effects may be mediated early in the progression of ARM to AMD and thus may not be detected by standard genome scans for more severe disease.