Does ammonia induce RNA oxidation in cultured astrocytes and brain in vivo?
Cerebral RNA oxidation is identified as a not yet recognized consequence of acute ammonia intoxication. RNA oxidation may affect gene expression and local protein synthesis and thereby provide another link between reactive oxygen species (ROS)/reactive nitrogen oxide species (RNOS) production and ammonia toxicity.
In this cohort of Asian Indians in North India, presence of NAFLD showed independent relationships with sub-clinical inflammation.