Does curcumin induce apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells?
This study demonstrates that curcumin inhibits proliferation and induces apoptosis in THP-1 cells via inhibiting the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously. Our data suggest that curcumin is a promising anti-tumor agent in acute monocytic leukemia.
Cross innervation does seem to occur in mandibular central and lateral incisors. However, the success rates in these teeth with bilateral inferior alveolar nerve blocks were below 75%. The failure of the inferior alveolar nerve blocks to anesthetize the anterior teeth was the overriding reason for failure. Clinically, bilateral inferior alveolar nerve blocks to provide profound pulpal anesthesia in mandibular anterior teeth are not recommended on the basis of the results of this study.