Does l-Tryptophan in supraphysiologic concentrations stimulate collagenase gene expression in human skin fibroblasts?
These results demonstrate that L-tryptophan in supraphysiologic concentrations is a potent inducer of collagenase gene expression in vitro at a transcriptional level by human skin fibroblasts.
Patients with isolated CAE had higher CAC than control subjects, suggesting that atherosclerosis may be involved in the pathogenesis of isolated CAE. Patients with isolated CAE may have increased cardiovascular risk and should receive appropriate risk stratification and relevant medical treatment.