Do antibody to tropomyosin isoform 5 and complement induce the lysis of colonocytes in ulcerative colitis?
hTM5 acts as an autoantigen in UC. hTM5-specific IgG autoantibody in sera from UC patients induces C3b deposition and destruction of colonic epithelial cells, suggesting a direct pathogenic effect. If used as a diagnostic test to distinguish UC from CD, IFA would have 79% sensitivity and 100% specificity. Development of blocking antibodies may lead to novel therapies.
Primary-length extensively coated stems provided reliable fixation for ½ of our Paprosky Type I to IIIA femoral revisions. When considering the use of such a component, the revision surgeon should take into account a small risk of failed osseointegration and technical challenges associated with this technique.