Is erythrocyte insulin receptor tyrosine kinase activity increased in glyburide-treated patients with type 2 diabetes in good glycaemic control?
These findings are quite similar to previously published data in metformin-treated patients. As such, it is suggested that decreases in insulin receptor tyrosine kinase activity may contribute to the loss of insulin sensitivity in hyperglycaemic subjects (glucotoxicity), and that an improvement in glycaemic control, irrespective of how it is achieved, will help rectify this abnormality.
MELD score had no predictive ability for the outcomes of patients with hepatitis B ACLF after orthotopic liver transplantation.