Does hepatocyte growth factor secreted by ovarian cancer cells stimulate peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum?
We demonstrated that HGF secreted by ovarian cancer cells plays an important role in cancer peritoneal implantation.
East Asian variant ALDH2*2 genotypes and, hence, deficient ALDH2 activity were associated with CSA in Japanese. These data support further investigation of treatment targeting aldehydes for CSA.