Does proteasome inhibitor MG132 modulate inflammatory pain by central mechanisms in adjuvant arthritis?
Our results indicate that proteasome inhibitor MG132 attenuates pain in adjuvant arthritis by targeting the sensory neuropeptide substance P in the peripheral and central nervous systems. These effects may be mediated through the inhibition of NF-κB activation.
The higher rate of colonization amongst HCW raises the possibility of occupational risk as well as horizontal spread of infections.