Are plasminogen fragmentation and increased production of extracellular matrix-degrading proteinases associated with serous epithelial ovarian cancer progression?
These data suggest that proteolytic activity of the plasminogen activation cascade increases in serous epithelial ovarian carcinoma.
The calculated shear stresses exceeded by orders of magnitude the maximum physiologically tolerated stresses. This suggests that shear stresses associated with regurgitant jets in MHVs may damage the endothelial cells, leading to the activation of the inflammatory reaction, enhanced procoagulation, platelet activation and aggregation, and mechanical cell denudation.