CUSUM: a tool for early feedback about performance?
We recommend the use of this simple, yet versatile cusum technique in the early evaluation of a clinical procedure before its implementation.
If it is true that too little folic acid results in nervous tissue damage, as is accepted by the scientific community in regard to neural tube defects (NTDs), then it seems plausible that too much folic acid may result in nervous tissue damage associated with autism. Although the correlations described here do not provide proof of causation, these data provide an impetus for further study. Children who develop autism may be receiving a massive dose of folic acid in utero, as well as, after birth. It would be of interest to carry out a case-control study using medical record data to document folic acid intake for pregnant women whose offspring were later diagnosed with autism and controls.