Does prostaglandin D ( 2 ) synthase induce apoptosis in pig kidney LLC-PK1 cells?
We report on the induction of apoptosis by PGD(2)S in LLC-PK1 pig kidney epithelial cells, and speculate that the accumulation of PGD(2)S in the serum of kidney failure patients may further exacerbate renal problems and is most likely regulated by other prostaglandins and growth factors.
These findings suggest that NO may prevent statin-induced myopathy.