Is sIN1 , a critical component of the mTOR-Rictor complex , overexpressed and associated with AKT activation in medullary and aggressive papillary thyroid carcinomas?
Sin1, a critical factor of the mTORC2 complex is overexpressed in clinically aggressive thyroid cancer types and is associated strongly with activation of AKT kinase. Sin1-dependent AKT activation might represent a target for experimental therapy.
There was no association between BMI SDS and age at diagnosis in children with new onset T1D. Further studies are needed to test whether the accelerator hypothesis is relevant in developing countries.