Does magnesium prevent phosphate-induced calcification in human aortic vascular smooth muscle cells?
Increasing Mg(2+) concentrations significantly reduced VC, improved cell viability and modulated secretion of VC markers during cell-mediated matrix mineralization clearly pointing to a cellular role for Mg(2+) and 2-APB further involved TRPM7 and a potential Mg(2+) entry to exert its effects. Further investigations are needed to shed light on additional cellular mechanism(s) by which Mg(2+) is able to prevent VC.
In experimental meningitis increase in volume and water diffusion of the hippocampus are significantly associated with accompanying bacteremia.