Does aldosterone regulate vascular gene transcription via oxidative stress-dependent and -independent pathways?
This study defines the Aldo-regulated vascular transcriptome and characterizes a subset of proatherogenic genes with enhanced Aldo-stimulated, oxidative stress-dependent expression in the setting of vascular injury and in areas predisposed to atherosclerosis. Inhibition of MR regulation of these genes may play a role in the protective effects of Aldo antagonists in patients with vascular disease, and these pathways may provide novel drug targets to prevent atherosclerosis in humans.
RIP and nisin could be used in combination to coat medical devices to prevent drug resistant S. epidermidis infections.