Is islet amyloid polypeptide response to maximal hyperglycemia and arginine altered in impaired glucose tolerance and type 2 diabetes mellitus?
Basal IAPP secretion is higher in T2DM and IGT versus NGT but is reduced in response to hyperglycemia and arginine. The IAPP/C-peptide ratio is reduced with prolonged and more severe hyperglycemia in T2DM individuals.
Our studies indicate that IQGAP1 is a novel essential component of the CXCR2 "chemosynapse".