Does genetics of experimental allergic encephalomyelitis support the role of T helper cells in multiple sclerosis pathogenesis?
These results support the polygenic model of MS/EAE, whereby MHC and multiple minor loci are required for full susceptibility, and confirm a critical genetic dependence on CD4 T(H)-cell differentiation and function in the pathogenesis of both diseases.
Rectal distension inhibits postprandial small intestinal motor activity in a distension volume-dependent manner in dogs, and this inhibitory effect is at least partially mediated via the alpha and beta adrenergic pathways and does not involve any alterations in intestinal slow waves.