Is p16 a major inactivation target in hepatocellular carcinoma?
Among the 3 cell cycle regulator proteins encoded at the 9p21 genetic locus, inactivation of p16 is the most frequent event in HCCs in which promoter hypermethylation and homozygous deletions are the common mechanisms.
Ginsenoside Rg3 protected INS-1 cell death from IHG with reducing apoptosis and increasing proliferation.