Are thiazolidione derivatives targeting the histidine kinase YycG effective against both planktonic and biofilm-associated Staphylococcus epidermidis?
The bactericidal and biofilm-killing activities of the new anti-YycG compounds were significantly better than the parent Compound 2.
These results show that leishmania exosomes are selectively and specifically enriched in small RNAs derived almost exclusively from non-coding RNAs. These exosomes are competent to deliver their cargo of novel, potential small regulatory RNAs to macrophages where they may influence parasite-host cell interactions. The remarkably high degree of congruence in exosomal RNA content between L. donovani and L. braziliensis, argues for the presence of a conserved mechanism for exosomal RNA packaging in leishmania. These findings open up a new avenue of research on non-canonical, small RNA pathways in this trypanosomatid, which may elucidate pathogenesis and identify novel therapeutic approaches.