Does heparin fail to inhibit the leukocyte recruitment for an extended time following inflammatory stimulus?
These findings show that the heparin effect on leukocyte recruitment varies depending on its dosage and the duration of the inflammation.
DPG has a protective effect on colitis and inflammation through the inhibition of oxidative stress. This study clarifies the two-ways mechanism by which DPG inhibits iNOS and COX-2 during inflammation and demonstrates for the first time that AMPK is a target of DPG. Uncovering this mechanism is significant to clarify the relationship between energy homeostasis and anti-oxidative responses and suggests that DPG could play a relevant role in the development of new therapy against inflammatory diseases associated to oxidative stress.