Is telomerase reverse transcriptase promoter mutation an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis?
Frequency of TERT promoter mutations rapidly increases during the different steps of the transformation of premalignant lesions into HCC on cirrhosis. Consequently, somatic TERT promoter mutation is a new biomarker predictive of transformation of premalignant lesions into HCC.
Calculations of organ doses for the CT examination of the thorax and abdomen can lead to considerable errors due to different topographic relations between phantom and man. In contrast the calculated effective dose is realistic. Hence, dose calculations with the help of mathematical phantom is an efficient method to estimate the total radiogenic risk.