Does the Drosophila Anion Exchanger ( DAE ) lack a detectable interaction with the spectrin cytoskeleton?
Based on the lack of colocalization and the lack of sequence conservation at the ankyrin-binding site, it appears that the well-characterized interaction between AE1 and the spectrin cytoskeleton in erythrocytes is not conserved in Drosophila. The results establish a pattern in which most of the known interactions between the spectrin cytoskeleton and the plasma membrane in mammals do not appear to be conserved in Drosophila.
These findings provide evidence for the specific involvement of SERT in MDMA reinforcing properties.