Does wortmannin inhibit the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase?
The results of the current study demonstrate that wortmannin can inhibit the growth of murine and human mammary tumors despite the presence of novel wortmannin-insensitive PtdIns 3-kinases in these tissues suggesting that some other target is responsible for wortmannin's antitumor activity.
Weekend TV viewing in early childhood continues to influence BMI in adulthood. Interventions to influence obesity by reducing sedentary behaviors must begin in early childhood. Interventions focusing on weekend TV viewing may be particularly effective.