Is restenosis following angioplasty in the swine coronary artery inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor , RPR101511A?
RPR101511A, which acts by inhibition of the PDGFr-TK, completely prevented angiographic loss of gain following PTCA and significantly reduced histological intimal hyperplasia.
These findings suggest changes in the regulation of GH and ghrelin secretion dynamics in early stage HD patients that could become more prominent in the later stages of the disease.