Does deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuate cytotoxicity of human natural antibodies?
A DKO mice strain lacking both Gal and NeuGc antigens in several tissues has been generated. Comparing CDC of human sera against mouse thymocytes, the DKO strain shows a statistically significant but a small additional reduction in CDC compared to that already achieved in GalT(-/-) mice.
Simulated physiological in vivo hydrodynamic loading has no significant degradative effect on an innovative sutureless stent-graft made from POSS-PCU nanocomposite polymer. Sutureless technology incorporating nitinol stents proved to be robust, with no separation over an accelerated 10-year cycle, which may allow development of durable stent-grafts with better compliance.