Does protease-activated receptor-2 regulate the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis?
PAR2 negatively regulates the innate immune response to CVB3 infection and contributes to myocardial dysfunction. The antagonism of PAR2 is of therapeutic interest to strengthen the antiviral response after an infection with a cardiotropic virus.
These changes in synaptic transmission may contribute to the genesis of epilepsy and to seizure-associated memory deficits.