Is nuclear aldehyde dehydrogenase 1A1 ( ALDH1A1 ) expression a favorable prognostic indicator in colorectal carcinoma?
Whole-tissue is better than TMA for the detection of ALDH1A1 nuclear staining in CRC patients, and nuclear expression is associated with a better outcome. Cytoplasmic expression is not a suitable prognostic marker of CRC.
Addition of EDTA quantification into standard MS/MS tests is a simple and useful method to avoid false-positive or false-negative neonatal screening results in lanthanide fluorescence-based tests.