Does platelet-derived growth factor regulate breast cancer progression via β-catenin expression?
Our results suggest that PDGF-BB regulates protein expression of β-catenin and is associated with cancer cell behavior.
This study suggests that acquired TKI resistance should be managed aggressively. The higher antitumor response and survival outcome with a taxane-based regimen in this retrospective study could encourage further prospective investigation to confirm the efficacy of taxane over nontaxane chemotherapy in patients with NSCLC whose disease progresses with EGFR TKI treatment.