Is exercise training following lung transplant now evidence-based practice?
In patients following lung transplant, exercise training conferred immediate and sustained gains in physical activity during daily life and exercise capacity. Gains in HRQL also appear to be evident, but took longer to be realised.
We here show that FGFR-mediated reactivation of the MAPK pathway attenuates the antiproliferation effects of imatinib in GISTs. The imatinib-induced ERK rebound can be repressed by the FGFR inhibitor BGJ398, and combined KIT and FGFR inhibition leads to increased efficacy in vitro and in patient-derived xenografts.