Is harm avoidance associated with progression of parkinsonism in community-dwelling older adults : a prospective cohort study?
A higher level of the harm avoidance trait is associated with a more rapid progression of parkinsonism in older adults.
This is the first large-scale genetic association study of circulating NT-proANP levels performed with replication and functional assessment that identified genetic variants in the MTHFR-CLCN6-NPPA-NPPB cluster to be significantly associated with NT-proANP levels. The clinical significance of this variation is related to lower NT-proANP levels, higher blood pressures, and an increased risk of stroke in the general community.