Does umbilical cord blood expansion with nicotinamide provide long-term multilineage engraftment?
UCB-derived hematopoietic stem and progenitor cells expanded in the presence of nicotinamide and transplanted with a T cell-containing fraction contain both short-term and long-term repopulating cells. The results justify further study of NiCord transplantation as a single UCB graft. If long-term safety is confirmed, NiCord has the potential to broaden accessibility and reduce the toxicity of UCB transplantation.
The present study provided some evidences that the impairment of host immunity induced by PDAC may play a role in the survival of patients.