Is signal transducer and activator of transcription 3 involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion?
Insulin-induced cardioprotection at reperfusion occurs through activation of STAT3. Inhibiting STAT3 by AG490, or STAT3 depletion in cardiac myocytes affects activation of Akt, suggesting close interaction between STAT3 and Akt in the cardioprotective signalling pathway activated by insulin treatment at reperfusion.
The mean hepatic AEF can provide an accurate, fast, noninvasive assessment of the degree of fibrosis in chronic liver disease.