Is the FSHD atrophic myotube phenotype caused by DUX4 expression?
These results constitute a proof of concept for the development of therapeutic approaches for FSHD targeting DUX4 expression.
Ventricular restoration affords significant improvement in ejection fraction compared with coronary artery bypass alone, without added mortality. Most importantly, left ventricular restoration reduces late morbidity and mortality compared with coronary artery bypass alone in patients with large ventricles.