Does tumor necrosis factor alpha negatively regulate the expression of the carcinoma-associated antigen epithelial cell adhesion molecule?
The current results provide the first insights into the regulation of EpCAM expression, which is regulated negatively by TNFalpha and TPA through the activation of NF-kappaB. The repression may rely on the competition of NF-kappaB for p300/CBP histone acetyl transferase activity, because the overexpression of p300 reverts TNFalpha effects.
Together with previous otoacoustic emission measurements in humans, this result demonstrates that the suppressive effect of contralateral noise suppression is greater when measured with compound action potential than otoacoustic emissions, and that contralateral sound suppressive effect is at least as strong in humans as in animals.