Are genetic variants in TNF-alpha but not DLG5 associated with inflammatory bowel disease in a large United Kingdom cohort?
We have confirmed an association between the TNF-857 promoter polymorphism and IBD in a large independent UK dataset but were unable to replicate an association at the previously reported loci within DLG5. This may reflect heterogeneity between the populations, a smaller effect size than originally predicted, or possibly a false-positive result in the original study. Further fine mapping studies of the TNF promoter region and studies assessing functional consequences of TNF promoter polymorphisms are now required in IBD.
Low GGT level does not predict a SVR; however, it may be a predictor of high fibrosis scores.