Is lymphopenia in patients with chronic idiopathic neutropenia associated with decreased number of T-lymphocytes containing T-cell receptor excision circles?
The aberrant T-cell expansions associated with the pathogenesis of CIN result in increased proliferation/apoptosis and possibly exhaustion of peripheral blood T cells which, in association with the inadequate compensatory thymic export of new TREC expressing T cells partially because of IL-7 deficiency, may contribute to lymphopenia in CIN.
Despite the fact that the component gap values were significantly higher compared to the original gap value in deep flexion, there is a positive correlation between the original and component gap throughout the ROM. The discrepancy during deep flexion was due to the posterior design of the prosthesis that is designed to be thinner than the actual thickness of the posterior osteotomy. These results suggest that the tibia first technique with the tensor have the advantage that surgeons can predict final soft tissue tension before femoral osteotomies with the prosthetic design and help restore natural knee kinematics, potentially improving implant survival and functional outcomes.