Does lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibit hepatocellular carcinoma growth through down-regulation of stathmin?
Results from our study suggested for the first time that EZH2 plays a key role in HCC tumorigenesis, and is a novel therapeutic target for HCC.
The results suggest that suppression of the TNF-alpha expression by EPA is partly attributed to its inhibitory effect on NF-kappaB activation. EPA appears to prevent NF-kappaB activation by preventing the phosphorylation of IkappaB-alpha.