Do folliculin deficient renal cancer cells show higher radiosensitivity through autophagic cell death?
Findings suggest that folliculin deficient renal cell carcinoma cells are highly sensitive to irradiation due to increased autophagic cell death, unlike other types of renal cell carcinoma. Irradiation plus autophagy inducers, eg rapamycin, might be a potentially more effective therapeutic approach to folliculin deficient renal cell carcinoma.
Defective MBL2 polymorphisms did not predict increased IPD susceptibility in children born in Northern Europe.