Is polymorphism in the TNF-alpha gene promoter at position -1031 associated with increased circulating levels of TNF-alpha , myeloperoxidase and nitrotyrosine in primary Sjögren 's syndrome?
Polymorphism in the TNF-alpha gene promoter at position -1031 is associated with increased circulating levels of TNF-alpha which is correlated with increased plasma MPO activity and protein nitration in Sjögren's syndrome.
This study demonstrates that HLA-class-II-bearing HCE cells can activate allogeneic PBL by a major histocompatibility complex class II-dependent mechanism. In addition, HCE cells may regulate immune reactions, probably through prostaglandin production caused by IL-1.