Do ewing tumors that overexpress BMI-1 are a distinct molecular subclass with variant biology : a report from the Children 's Oncology Group?
ESFT that do not overexpress BMI-1 represent a novel subclass with a distinct molecular profile and altered activation of and dependence on cancer-associated biological pathways.
Our findings provide direct in vitro and in vivo evidence for spreading of β-amyloid through neuronal connections, and suggest possible therapeutic approaches to blocking this spread.