Does glucosamine Hydrochloride but Not Chondroitin Sulfate prevent Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants?
The results suggest that GH prevents cartilage degradation mediated by aggrecanases ADAMTS-4 and -5, and may also reduce inflammation. This could be part of the mechanisms by which GH is effective in maintaining joint integrity and function, and preventing or delaying early symptoms of OA.
MCAK is a cognate substrate of PAK1.