Is lipoprotein internalisation induced by oncogenic AMPK activation essential to maintain glioblastoma cell growth?
Our findings demonstrate that AMPK plays a crucial role in glioblastoma cell growth and suggest that blocking lipoprotein receptors could potentially be used as a plausible therapeutic approach for these and other type of tumours with high levels of AMPK.
The results suggested that low dose of LPS pretreatmemt induced increased CSC migration, reduced the infarct size of ischemia-reperfusion heart. The mechanism might be due to the activation and translocation of β-catenin via HSP90-dependent manner.