Does sustained vascular endothelial growth factor delivery enhance angiogenesis and perfusion in ischemic hind limb?
The PLG-VEGF scaffolds resulted in sustained VEGF delivery, improved tissue perfusion, greater capillary density, and more mature vasculature compared to the controls. The sustained-release PLG polymer vehicle is a promising delivery system for therapeutic neovascularization applications.
The TF-MUSIC algorithm is suitable for extracting a target response whose spectrum changes significantly during the observation.