Is the urine output definition of acute kidney injury too liberal?
A 6-hour urine output threshold of 0.3 ml/kg/hour best associated with mortality and dialysis, and was independently predictive of both hospital mortality and 1-year mortality. This suggests that the current AKI urine output definition is too liberally defined. Shorter urine collection intervals may be used to define AKI using lower urine output thresholds.
Overall, these data indicate that running-wheel access modulates microglia activation, but these effects vary by age, sex, and brain region.