Is efficiency of Xist-mediated silencing on autosomes linked to chromosomal domain organisation?
This study provides insight into the requirements for efficient Xist mediated silencing and specifically identifies organisation of the chromosome into gene-rich L1-depleted and gene-poor L1-dense domains as a major influence on the ability of Xist-mediated silencing to be propagated in a continuous manner in cis.
Our results suggest that the level of lipids inside RPE cells is one of the critical factors for initiating epithelial-mesenchymal transition (EMT) processes of the PVR condition and implicate casticin as a new therapeutic modality for RPE-associated retinal disease conditions.