Does rectal gel application of Withania somnifera root extract expound anti-inflammatory and muco-restorative activity in TNBS-induced inflammatory bowel disease?
Dose of the rectal gel applied at 1000 mg of WSRE per kg rat weight showed significant muco-restorative efficacy in the IBD-induced rats, validated by histo-pathological studies.
These results for the first time demonstrated that SalA protected against IS/RP-induced endothelial barrier dysfunction through suppression of VLDL receptor expression.