Is serum carboxymethyl-lysine , a dominant advanced glycation end product , associated with chronic kidney disease : the Baltimore longitudinal study of aging?
Serum CML, a dominant AGE, is independently associated with CKD and eGFR.
Our results support the concept that a reduced tissue availability of fatty acids consequent to a massive lipid malabsorption influences glucose metabolism acting through the regulation of PDH complex. In fact, as shown in animals, a higher level of FFA availability is likely to induce overexpression of PDK4 also in humans.