Does fluoxetine inhibit calcium-activated currents of salamander rod photoreceptor somata and presynaptic terminals via modulation of intracellular calcium dynamics?
We conclude that in addition to blocking ICl(Ca), fluoxetine inhibits IK(Ca). We further conclude that the inhibition of both of these currents is the consequence of inhibition of the normal sustained elevation in intracellular calcium following depolarization and initial calcium influx. Combined, the data suggest that fluoxetine may have multiple sites of action in rod photoreceptors instead of acting as a specific inhibitor of ICl(Ca).
Inflammation was associated with morphological and clinical progression of atherosclerotic disease. Patients with elevated levels of hs-CRP exhibit an increased risk for adverse cardiovascular outcome attributable to clinical adverse events of progressive atherosclerotic disease.