Does vascular leak ensue a vigorous proinflammatory cytokine response to Tacaribe arenavirus infection in AG129 mice?
Our findings suggest that vascular leak may be a contributing factor in the demise of TCRV-infected mice, as histopathologic findings are generally mild to moderate in nature, and as evidenced with MY-24 treatment, animals can survive in the face of high viral loads.
We propose that sensitivities to ethanol- and ketamine-induced locomotion are genetically correlated and that the combined effects of ethanol and ketamine in FAST mice reflect a leftward shift in ethanol's biphasic dose-response curve.