Does a synthetic triterpenoid selectively inhibit the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines?
This study demonstrates that CDDO is a novel inhibitor of MMP-1 and MMP-13 gene expression mediated by inflammatory cytokines. Thus, CDDO may have therapeutic potential for the inhibition of joint degradation in osteoarthritis.
The findings are discussed within the framework of attribution theory, and in the context of viewing physical therapy as an applied biomedical science or a caring profession. In this study, the view of physical therapy as a caring profession prevailed among the majority of the physical therapists.