Is wnt but not BMP signaling involved in the inhibitory action of sclerostin on BMP-stimulated bone formation?
Sclerostin inhibits BMP-stimulated bone formation but does not affect BMP signaling. Instead, it antagonizes Wnt signaling in osteoblastic cells. High bone mass in sclerosteosis and van Buchem disease may, therefore, result from increased Wnt signaling.
Our findings suggest that 4-MU induces apoptosis in CML cells by activating components associated with the intrinsic apoptosis pathway.