Does puerarin decrease bone loss and collagen destruction in rats with ligature-induced periodontitis?
Puerarin reduced the alveolar bone loss and collagen destruction in rats with ligature-induced periodontitis by inhibiting the production of RANKL, IL-1β, TNF-α, MMP-2 and MMP-9. Thus, puerarin can be considered a promising agent for adjunctive therapy of periodontitis.
This study suggests that a reduced recruitment of naïve T-helper cells and increased frequency of T-helper cells with lymph node homing marker expression reflect mucosal healing in IBD. Surprisingly, the degree of activation of mucosal T-helper cells did not correlate with disease remission.