Do alkylphosphocholines inhibit proliferation of human retinal pigment epithelial cells?
APCs inhibit proliferation of RPE cells and RPE-mediated matrix contraction in vitro at nontoxic concentrations. This effect seems to be exerted through inhibition of PKC activity. Therefore, APCs are promising candidates for treatment of RPE-mediated proliferative processes such as proliferative vitreoretinopathy.
Our results indicate the importance of mastery in relation to diabetes patients' perceived autonomy support, self-management skills and HRQOL.