Is the Alcohol Intolerance Produced by Isoniazid Due to a Disulfiram-Like Reaction Despite Aldehyde Dehydrogenase Inhibition?
Our results demonstrate for the first time that despite ALDH inhibition ISO does not provoke a typical DIS-like reaction since it does not increase blood acetaldehyde levels after co-administration with ETH. The possibility that the ETH intolerance observed in ISO treatment is a central synergistic effect cannot be excluded.
It is suggested from this study that brief (Garcina manii) stick-chewing confers a caries prevention/control benefit by reversing acidogenic challenge to teeth.