Does the aging process significantly modify the Mean Heart Rate?
The MHR decreased with age. Women had higher values of MHR, regardless of the age group. Correlations between MHR and age or gender, albeit significant, showed the effect magnitude had little statistical relevance. The prevalence of SAH, dyslipidemia and diabetes mellitus did not influence the results.
Up-regulation of OGN in response to Ang II stimulation inhibits CFs proliferation and migration and protects against hypertensive cardiac interstitial fibrosis. Therefore, targeting OGN is a promising strategy for hypertensive cardiac remodeling.(Figure is included in full-text article.).