Is autoinsertion of soluble oligomers of Alzheimer 's Abeta ( 1-42 ) peptide into cholesterol-containing membranes accompanied by relocation of the sterol towards the bilayer surface?
Cholesterol is known to regulate membrane lipid order, and this can affect a wide range of membrane mechanisms, including intercellular signalling. Previously unrecognised Abeta-dependent rearrangement of the membrane sterol could have an important role in AD.
The pretreatment with nitrous oxide is a time effective and safe method for use at paediatric outpatient departments to reduce pain, facilitate venous cannulation, and thereby reduce the number of costly cancellations of planned procedures.