Does activating transcription factor 3 gene expression suggest that tissue stress plays a role in leiomyoma development?
Alterations in ATF3 gene expression resemble the response to mechanical and ischemic stress reported in other tissues. Results suggested that ATF3 protein expression was increased in leiomyoma, and may reflect increased tissue stress.
Up-regulation of NMDA receptor activity or oxygen free radical production elicited by cerebral ischemia contributes to AMPK activation and increment of glucose uptake through facilitating the transportation of GLUT4 to the plasma membrane, involving in regulation of energy metabolism.