Does synthetic LXR agonist T0901317 attenuate lipopolysaccharide-induced acute lung injury in rats?
The expressions of LXRs were significantly decreased and synthetic agonist T0901317 suppresses lung inflammatory responses and lightened histopathologic changes of lung in rats with ALI. The mechanisms of this action for T0901317 may associate with the inhibition of NF-κB activation and downregulation of adhesion molecules ICAM-1 gene.
The preservation of residual hearing after conventional CI is possible. Young age seems to have a positive impact on hearing preservation.