Does sevelamer hydrochloride prevent ectopic calcification and renal osteodystrophy in chronic renal failure rats?
These results suggest that sevelamer treatment might contribute to the suppression of ectopic calcification and ROD.
CYP3A4 seems to be of minor importance in clozapine metabolism in humans. Itraconazole, and probably also other inhibitors of CYP3A4, can be used concomitantly with clozapine.