Do tEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases?
The deletion of the central region did not affect the TEL/AML1-specific phenotype; we did not find any relevant differences in clinical and biological features when variant versus classical TEL/AML1-positive cases were compared. Thus, our data does not support hypothesis that the central region of TEL is indispensable for TEL/AML1 driven leukemogenesis.
The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC.