Does peptide deformylase inhibitor actinonin reduce celastrol 's HSP70 induction while synergizing proliferation inhibition in tumor cells?
Concurrent use of the chemical agent actinonin could reduce celastrol's HSP70 elevation and also enhance proliferation inhibition by celastrol. This combination presents a novel alternative to siRNA technology and is worth further investigation for its potentially effective anti-tumor action.
Behavioral depression/learned helplessness can be maintained over time by processes that may be similar to those occurring in depression and PTSD, thereby strengthening the possibility that this paradigm is indeed a reasonable model of these disorders.