Could the expression of L-selectin be an early marker of arterial hypertension and microangiopathy in the course of type 1 diabetes mellitus in juvenile patients?
In juvenile patients with type 1 diabetes the percentage of T lymphocytes expressing L-selectin was increased independently on the du-ration of the disease. In children with type 1 diabetes and diagnosed vascular complications the highest percentage of T lymphocytes expressing L-selectin was found.
AVS is associated with a thinner aortic wall at the level of the sinus of Valsalva. This novel finding suggests that a thinner aortic wall, a reflection of its constituents, likely acting through its contribution to reduced aortic compliance and increased aortic stress, leads to the thickening of aortic valve leaflets characteristic of AVS. Further understanding of this relationship may unravel the pathophysiology of this type of aortic valve disease.