Do human eosinophils preferentially survive on tissue fibronectin compared with plasma fibronectin?
These observations show preferential survival of eosinophils cultured on tissue Fn as a result of alpha 4 beta 1-dependent interaction with the CS-1 region of tissue Fn triggering autocrine cytokine synthesis and release, thereby promoting their survival and persistence within the tissues.
The marrow explant model indicates the inflammatory and immune pathways to be an integral part of the osteogenesis process.