Does chronic tachygastrial electrical stimulation reduce food intake in dogs?
TES at the distal antrum results in a significant reduction in food intake in dogs, and this inhibitory effect is probably attributed to TES-induced reduction in proximal gastric tone, gastric accommodation, antral contractility, and gastric emptying. These data suggest a therapeutic potential of the specific method of TES for obesity.
We discovered novel and independent associations of prediabetes and related traits with MASP1, and some evidence for associations with THBS1, GPLD1 and ApoA-IV, suggesting a role for these proteins in the pathophysiology of type 2 diabetes.