Is a photodynamic therapy combined with topical 5-aminolevulinic acid and systemic hematoporphyrin derivative more efficient but less phototoxic for cancer?
The combined PDT not only shows high cure rate for skin cancers but also decreases the dose of the pro-toxic HPD and significantly shortens the photosensitive period, from which the patients are able to benefit.
These findings are indicative of antigen-dependent network perturbation being a causative factor in polyclonal lymphocyte activation.