Are multiple superoxide dismutase 1/splicing factor serine alanine 15 variants associated with the development and progression of diabetic nephropathy : the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study?
Multiple variations in SOD1 are significantly associated with persistent microalbuminuria and severe nephropathy in the DCCT/EDIC study.
Among its other biological activities, pifithrin-alpha is an inhibitor of firefly luciferase activity. Caution must therefore be taken when using this compound, which has been characterised as an inhibitor of p53 transcriptional activity, to investigate effects on gene expression using transiently transfected reporter plasmids. Furthermore, these results demonstrate that when using novel compounds, the choice of vectors used in the experimental procedures might be of great importance for the correct conclusions to be made.