Does pertussis toxin normalize enhanced renovascular responses to angiotensin II in spontaneously hypertensive rats?
1) Gi and/or Go contributes importantly to the signalling mechanism through which Ang II affects renal vascular resistance; and, 2) An alteration in the Gi and/or Go-mediated signalling pathway in the renal vasculature appears to mediate the enhanced renal vascular response to Ang II in SHR.
MicroRNA-375 regulates invadopodia maturation and function potentially by suppressing the expression and secretion of proteases.