Does matrix Metalloproteinase-12 induce Blood-Brain Barrier Damage After Focal Cerebral Ischemia?
These results demonstrate the adverse role of MMP-12 in acute brain damage that occurs after ischemic stroke and, thereby, suggesting that MMP-12 suppression could be a promising therapeutic target for cerebral ischemia.
This study provides encouraging evidence as to the effectiveness of  intense PT for individuals with SCI. Future research is needed to identify the optimal therapy dosage and specific therapeutic activities required to generate clinically meaningful recovery for individuals with SCI including those who elect to undergo a neural recovery/regenerative surgical  procedure and those that elect intense therapy alone.