Does [ Nuclear protein 1 knockdown inhibit proliferation and migration of HepG2 cells ]?
Knockdown of Nupr1 inhibited the proliferation and migration of HepG2 hepatocellular carcinoma cells.
This report defines the role of trypsin in AP and shows that cytosolic cathepsin B but not trypsin activates cell death pathways. This report also suggests that trypsin is a requisite for AP only because it causes release of cathepsin B into the cytosol.