Do genetic variants of pulmonary SP-D predict disease outcome of COPD in a Chinese population?
Genetic haplotype of SP-D may serve as a valuable prognostic indicator in Chinese patients with COPD.
In patients developing RO, increases in oesophageal HIF-2α correlate with increased pro-inflammatory molecule expression. In oesophageal epithelial cells, acidic bile salts stabilise HIF-2α, which mediates expression of pro-inflammatory molecules. HIF-2α appears to have a role in RO pathogenesis.