Does application of a graded Sorensen test evoke spatially organized lumbar muscle fatigue?
By using this modified Sorensen test, muscular fatigue can be evoked. Electrophysiological assessment of lumbar fatigue should consider spatial differences.
In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway. In vivo, AND significantly retarded tumor growth and caused regression of well-formed tumors in vivo. Furthermore, AND did not induce apoptosis or activate ERK and p53 in primary cultured astrocyte cells, and it may serve as a potential therapeutic candidate for the treatment of glioma.