Is surveillance of small renal masses safe in the elderly?
Increased size of tumour increases the risk of malignancy and the likelihood of high-stage and high-grade disease. Among patients aged>75 years there was a higher risk of malignancy and high-stage disease than in those aged ≤ 75 years. As such, the decision for observation should not be based upon age alone, and should be approached with caution in patients aged>75 years, particularly for larger lesions.
We demonstrated an activation of Wnt-2 signaling via the Frizzled-8 receptor in NSCLC cells. A novel dnhWnt-2 construct significantly inhibits Wnt-2 signaling, reduces colony formation of NSCLC cells in vitro and tumor growth in a xenograft mouse model. The dnhWnt-2 construct may provide a new therapeutic avenue for targeting the Wnt pathway in lung cancer.