Does administration of systemic matrix metalloproteinase inhibitors maintain bone mechanical integrity in adjuvant arthritis?
These data suggest that tetracycline derived antimetalloproteinase compounds can significantly and positively influence bone mechanical integrity associated with inhibition of collagen breakdown.
We propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease.