Is lung growth induced by tracheal occlusion in the sheep augmented by airway pressurization?
TO results in a gradual increase in ITP over 15 to 24 hours, which plateaus at 4 to 5 mm Hg. Further increasing ITP by infusion of crystalloid significantly augments lung growth beyond that observed with TO alone. These data support the hypothesis that airway pressure and secondary mechanical stretch are the primary stimuli of TO induced lung growth.
Ketamine's antidepressant efficacy may occur independently of baseline peripheral vitamin levels.