Are confirmatory assays essential when using molecular testing for Neisseria gonorrhoeae in low-prevalence settings : insights from the third National Survey of Sexual Attitudes and Lifestyles ( Natsal-3 )?
We highlight the low PPV for gonorrhoea of an unconfirmed reactive test when deploying molecular testing in a low-prevalence population. Failure to undertake confirmatory testing in low-prevalence settings may lead to inappropriate diagnoses, unnecessary treatment and overestimation of population prevalence.
These data suggest that increased apelin receptor expression by SMC provides a paracrine pathway in injured vessels that allows endothelial-derived apelin to stimulate their division and migration into the neointima.