Do loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells?
These results indicate that loratadine and its main metabolite have anti-inflammatory activity by inhibiting the release of preformed and de novo synthesized mediators from human Fc epsilon RI+ cells.
Potassium hydroxide and culture results were not available to correlate with histology. PAS staining of nail clippings has inherent diagnostic limitations.