Does pretransplant donor peripheral blood mononuclear cells infusion induce transplantation tolerance by generating regulatory T cells?
Donor-specific regulatory T cells play a role in tolerance induction by donor PBMC infusion. Regulatory activity is concentrated in the CD4+ CD25+ subset and requires cell-to-cell contact. Regulatory CD4+ T cells accumulate in tolerized kidney grafts where they could exert a protective function against host immune response.
More frequent self-weighing seemed to be most beneficial for obese individuals. These findings may aid in the refinement of self-weighing frequency recommendations used in the context of weight management interventions.