Does tissue inhibition of angiotensin-converting enzyme activity stimulate angiogenesis in vivo?
ACE inhibition with quinaprilat promotes angiogenesis in a rabbit model of hindlimb ischemia. Thus, nonsulfhydryl ACE inhibitors with high tissue affinity may be potentially useful for therapeutic angiogenesis in ischemic tissues. Moreover, previous evidence that ACE inhibition benefits patients with myocardial ischemia may be due in part to augmented collateral development.
Plasma tHcy is the best marker of those measured to investigate suspected tissue deficiency of cobalamin/folate.