Is macrophage migration inhibitory factor ( MIF ) -173 polymorphism associated with clinical erythema nodosum in Löfgren 's syndrome?
The MIF -173C allele is associated with erythema nodosum in Löfgren's syndrome, but not with susceptibility to sarcoidosis. This indicates a role for MIF after antigen presenting to the T cell has taken place and the sarcoid inflammatory response has begun.
This study provides evidence for association of SNPs in the RPTPsigma gene with T2D in Swedish Caucasians. SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing T2D.