Does formoterol thrice weekly result in the development of tolerance to bronchoprotection?
Thrice weekly dosing does not result in the development of tolerance to bronchoprotection against the direct acting stimulus methacholine.
Reduction and adduct formation by GSH likely limits the reactivity of bisretinoid photoproducts and may aid their elimination from the cells. These findings are significant to forms of macular degeneration associated with bisretinoid formation and maculopathy stemming from GSH synthase deficiency.