Does contact frequency determine outcome of basal insulin initiation trials in type 2 diabetes?
The frequency of contact with the study team is highly correlated with the improvement in HbA(1c) achieved in basal insulin initiation trials in type 2 diabetic patients. This has important implications for trial design and interpretation, as well as for clinical care.
Our results support a role for MMP-2 in mediating cross-talk between epithelial cells and myofibroblasts.