Are sex hormones weak regulators of HPV16 DNA-immortalized human uterine exocervical epithelial cells?
These results suggest that the proliferation of HCE16/3 cells is still dependent on growth factors and sex hormones upregulate the HPV 16 early gene expression. More researches should be done before elucidating the effects of sex hormones on human cervical cancinogenesis.
Diabetics with erectile dysfunction often have a CFR in the lower range of normal. Sildenafil did not further reduce CFR. Asymptomatic, severe coronary artery disease often can be found in diabetics with erectile dysfunction. Cardiological screening for contraindications for sildenafil seems mandatory in diabetics with a high cardiovascular risk profile.