Does high aldolase with normal creatine kinase in serum predict a myopathy with perimysial pathology?
Selectively elevated serum aldolase is associated with syndromes including myopathies with discomfort and weakness, systemic disorders and myopathology in perimysial connective tissue. The myopathy with perimysial pathology and the associated clinical syndromes seen in our patients are similar to disorders associated with antisynthetase antibodies. In patients with muscle discomfort or mild weakness and a normal CK, measurement of serum aldolase can be useful in the evaluation of possible myopathies.
EFT, which has been suggested as a cardiometabolic risk factor in various diseases, is also independently associated with psoriasis.