Do interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro?
We showed that IL-6 in combination with its soluble receptor stimulates cellular SCF and Flt-3L expression in vivo and in vitro. Cellular upregulation of SCF and Flt-3L by IL-6/sIL-6R might be used for the development of new stroma cell systems for ex vivo expansion of hematopoietic progenitor cells.
Except for children whose motor skills regress substantially, children with dynamic developmental delays are less likely than their peers with persistent delays to receive EI. This finding suggests the need for improved understanding of developmental surveillance, referral, and use of EI services.