Does vitamin A exert its antiinflammatory activities in colitis through preservation of mitochondrial activity?
The results indicate that tissue damage in colitis is accompanied by the arrest of mitochondrial respiration, loss of mitochondrial DNA, and the expression of mitochondrial proteins. Vitamin A effectively protects colon mitochondria by upregulation of mitochondrial transcription factors, NFR-1 and TFAM, and prevents inflammatory and necrotic changes in colitis. Vitamin A is therefore a potential therapeutic agent in inflammatory bowel disease.
Independent of age, gender, and operative side, a majority of PCLs are more than 50% destabilized following the standard transverse tibial cut.