Does aminoguanidine prevent the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes?
AG therapy prevented not only the contractile dysfunction of the heart, but also the augmentation in LV internal resistance in rats with STZ and NA-induced type 2 diabetes.
The efficacy of HA14-1 is cell line dependent and is not reliant on apoptosis induction.