Is the combination of an mTORc1/TORc2 inhibitor with lapatinib synergistic in bladder cancer in vitro?
The combination of OSI-027 and lapatinib results in antitumor synergy and further exploration of this combination should be undertaken.
These findings, for the first time, provide direct evidence that P-wave-generating cells are critical for normal REM sleep-dependent memory processing. This evidence supports our hypothesis that the P-wave generator in the brainstem may act as an on switch to provide activating input to forebrain structures for sleep-dependent memory processing.