Does intracoronary shunt insertion prevent myocardial stunning in a juvenile porcine MIDCAB model absent of coronary artery disease?
Our data show that in a porcine MIDCAB model 15 min LAD occlusion and 30 min reperfusion result in significant myocardial stunning. In contrast, maintenance of LAD perfusion using intracoronary shunt insertion minimizes ischemia/reperfusion injury and prevents regional LV dysfunction. Although our experiments were conducted in healthy pig hearts absent from coronary artery disease, similar results may--at least partially--be expected in humans, and thus, intracoronary shunts could be a useful tool for myocardial protection during 'off-pump revascularization'.
These results describe the altered transportome profile in CD and open the possibility of restoring transportome complications with commensal bacteria.