Circulating tumor cells in metastatic colorectal cancer: do we need an alternative cutoff?
The presence of at least 1 CTC at baseline count is predictive for poor prognosis in mCRC patients. Patients with 1-2 CTC should be switched from the favorable prognostic group--conventionally defined by the presence of<3 CTC--to the unfavorable, deserving a more careful monitoring.
The response to bronchodilator treatment in patients not using aerosol inhalers correctly improves significantly upon use of either inhalation chambers or spacers with the former demonstrating the best results.