Is lipopolysaccharide ( LPS ) induction of nitric oxide synthase-2 and cyclooxygenase-2 impaired in fructose overloaded rats?
These results suggest that the metabolic alterations established by 15 weeks of F overload should affect the response to LPS challenge due to an attenuation in the induction of NOS-2 and COX-2. This effect would be one of the components contributing to abnormalities in the course of the inflammatory response in other conditions associated to insulin resistance, such as diabetes.
Although the heterosexual male:female ratio for gonorrhoea is one readily available and proxy measure of disease control and tracing efficiency, its sole use should be interpreted with caution. A time lag across quarters between patient and partner attendance and other recording anomalies may mislead. Ratios should therefore be interpreted in the context of partner notification outcomes, which give a more reliable measure of efficiency. The use of the ratio in critical evaluation of a unit's efficiency should be but one part of a package of measures.