Does the Fatty Acid Synthase Inhibitor Platensimycin improve Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys?
These findings demonstrate unique properties of PTM and provide proof-of-concept of FAS inhibition having potential utility for the treatment of diabetes and related metabolic disorders.
The NAMPT rs1319501 minor allele associates with increased MI risk in young women. In young men a protective effect of the AKT1 rs3730358 minor allele was suggested, possibly related to an attenuated inflammation.