Is impaired insulin sensitivity accompanied by disturbances in skeletal muscle fatty acid handling in subjects with impaired glucose metabolism?
IFG, IGT and IFG/IGT subjects have lower insulin sensitivity and impaired β-cell function compared with age- and BMI-matched NGT controls. The increased postprandial TAG response and higher muscle TAG extraction in both IFG and IGT compared with NGT may lead to ectopic fat accumulation in the skeletal muscle, thereby contributing to insulin resistance.
LKB1 loss at the transcriptional level via alteration of the NKX2-1/p53 axis promotes cell invasion, consequently resulting in poor outcome in colorectal cancer patients.