Is oxygen tissue saturation lower in nonsurvivors than in survivors after early resuscitation of septic shock?
In septic shock patients, tissue oxygen saturation below 78% is associated with increased mortality at day 28. Further investigations are required to determine whether the correction of an impaired level of tissue oxygen saturation may improve the outcome of these patients.
Mechanical restitution is affected by the mechanical events of preceding contractions, implying that previous beat contraction history and restitution share a common mechanism and that restitution sets the stage for previous beat contraction history. Hence restitution is not simply a useful tool for assessing calcium cycling or interval dependent behaviour and should be viewed more broadly as a fundamental process in the beat to beat regulation of cardiac contraction.