Diagnostic implications of informant disagreement about rage outbursts: bipolar disorder or another condition?
The context in which a rage outburst occurs may impact the diagnosis; however, diagnosis alone does not explain this difficult and impairing behavior.
Induction of PSC apoptosis upon alcohol withdrawal is a key mechanism mediating the resolution of pancreatic fibrosis. Conversely, continued alcohol intake perpetuates pancreatic injury by inhibiting apoptosis and promoting activation of PSCs. Characterisation of the pathways mediating PSC apoptosis has the potential to yield novel therapeutic strategies for chronic pancreatitis.