Does intrinsic Resistance to Cixutumumab be Conferred by Distinct Isoforms of the Insulin Receptor?
This study identifies total IR as a biomarker predictive of primary resistance to IGF-IR antibodies and provides a rationale for new clinical trials enriched for patients whose tumors display low IR expression.
Since KLF15 is an endogenous repressor of cardiac hypertrophy, our results suggest early administration of MR antagonists or addition to drug eluting stents for protection of the myocardium.