Is histologic eosinophilic gastritis a systemic disorder associated with blood and extragastric eosinophilia , TH2 immunity , and a unique gastric transcriptome?
EG is a systemic disorder involving profound blood and gastrointestinal tract eosinophilia, TH2 immunity, and a conserved gastric transcriptome markedly distinct from the eosinophilic esophagitis transcriptome. The data herein define germane cellular and molecular pathways of EG and provide a basis for improving diagnosis and treatment.
In this study, our results indicate that that leptin and cholesterol might play differently important pathophysiological roles in these psychiatric disorders.