Does vesnarinone inhibit induction of nitric oxide synthase in J774 macrophages and rat cardiac myocytes in culture?
Vesnarinone inhibited NO synthesis by inhibiting the induction of NOS in J774 macrophages and cardiac myocytes. This drug may exert a beneficial effect in patients with heart failure, in part, by attenuating the production of NO.
The possibility is raised that sleep restoration might induce a rapid antimanic response in patients experiencing their first episode of mania. The clinical implications of a rapid reversal of mania--including a reduction in number of hospital days--are discussed.