Are soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in synovial fluid correlated with disease severity of knee osteoarthritis?
SF sLOX-1 levels were independently and positively associated with disease severity in knee OA.
Our results indicate that the C allele of JAK2 rs4495487, in addition to the 46/1 haplotype, contributes significantly to the occurrence of JAK2 V617F-positive and JAK2 V617F-negative MPNs in the Japanese population. Because lack of the GCC genotype represents a distinct clinical-hematological subset of MPN, analyzing JAK2 SNPs and quantifying JAK2 V617F mutations will provide further insights into the molecular pathogenesis of MPN.