Does anti-inflammatory effect of antidiabetic thiazolidinediones prevent bone resorption rather than cartilage changes in experimental polyarthritis?
These data emphasize that higher dosages of thiazolidinediones are required for the treatment of arthritis than for restoring insulin sensitivity but that thiazolidinediones prevent inflammatory bone loss despite exposing animals to increased fatness possibly resulting from excessive activation of PPAR-gamma.
Gefitinib can improve insulin sensitivity in rats of type-2 diabetes. 2 t(1/2) after administration, the effect still existed. The effect probably due to the increase of PI3K/Akt pathway of insulin signaling, and had no relationship with body weight in our study dose range.