Does single-cell profiling of human megakaryocyte-erythroid progenitors identify distinct megakaryocyte and erythroid differentiation pathways?
Our study clarifies the cellular hierarchy in human megakaryocyte/erythroid lineage commitment and highlights the importance of using a combination of single-cell approaches to dissect cellular heterogeneity and identify rare cell types within a population. We present a novel immunophenotyping strategy that enables the prospective identification of specific intermediate progenitor populations in erythro-megakaryopoiesis, allowing for in-depth study of disorders including inherited cytopenias, myeloproliferative disorders, and erythromegakaryocytic leukemias.
Collectively, the outcome of innate and adaptive immune responses in AD is modulated by the TLR-2 R753Q SNP.