Are vitamin D deficiency and a CYP27B1-1260 promoter polymorphism associated with chronic hepatitis C and poor response to interferon-alfa based therapy?
Chronic hepatitis C virus infection is associated with vitamin D deficiency. Reduced 25-hydroxyvitamin D levels and CYP27B1-1260 promoter polymorphism leading to reduced 1,25-dihydroxyvitamin D levels are associated with failure to achieve SVR in HCV genotype 1, 2, and 3 infected patients.
Neuropsychological assessment focused on attention and cortisol measurement at three time points daily.