Do nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide?
ITK and BTK regulate thermal homeostasis during septic response through mast cell function in mice. They share regulatory function downstream of Toll-like receptor 4/LPS in mast cells, through regulating the activation of canonical nuclear factor kappa B, phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt, and p38 signaling pathways.
This study shows that patients with prostates of>or=50 mL have an IPSS comparable with those who have prostates of<50 mL. Large prostates should not be considered an exclusion criterion when an intraoperative planning technique is used for brachytherapy.