Is clevudine efficiently phosphorylated to the active triphosphate form in primary human hepatocytes?
These results are consistent with once daily CLV dosing currently being used in Phase III clinical studies.
These results demonstrate that etanercept partially restores the antinociceptive effect of morphine in morphine tolerance after a morphine challenge. Etanercept has potential for use in the clinical management of pain, particularly in patients who require long-term opioid treatment, and the effectiveness of which can be hampered by tolerance.