Are expression and activity of thimet oligopeptidase ( TOP ) modified in the hippocampus of subjects with temporal lobe epilepsy ( TLE )?
The results show that these alterations could be related to a failure in the mechanisms involved in clearance of inflammatory peptides in the hippocampus, suggesting an accumulation of potentially harmful substances in nervous tissue such as Aβ, bradykinin, and antigenic peptides. These accumulations could be related to hippocampal inflammation observed in TLE subjects.
We found no evidence of an improvement in physical function following vitamin D3 supplementation for 1 year.