Do cartilage Thickness and Cyst Volume Are Unchanged 10 Years After Periacetabular Osteotomy in Patients Without Hip Symptoms?
Ten years after PAO, approximately 25% of the patients who have the procedure will have substantial hip pain and/or undergo hip arthroplasty. Of the patients who do not have substantial hip pain or an arthroplasty, cartilage thickness appears to be preserved. Future studies are needed to help us decide which patients are most likely to succeed with PAO at long-term followup.
These data show that obese pregnant women demonstrate decreased skeletal muscle mitochondrial respiratory chain enzyme activity and decreased mitochondrial antioxidant defense. Furthermore, reduced skeletal muscle SIRT3 activity may play a role in the increased oxidative stress associated with pregnancies complicated by obesity.