Are hPV16 CpG methyl-haplotypes associated with cervix precancer and cancer in the Guanacaste natural history study?
This study demonstrates that NGS of bisulfite treated HPV DNA is a useful and efficient technique to survey methylation patterns in HPV16. This procedure provides quantitative information on both individual CpG sites and methyl-haplotypes that identify women with elevated present or subsequent risk for HPV16 CIN3 and cancer.
We provide a scientific rationale for the use of sorafenib in combination with radiotherapy in colorectal cancer.