Does methylnaltrexone potentiate body weight and fat reduction with leptin?
The data suggest the existence of a peripheral opioid-related mechanism in leptin-active modulation of body weight.
In experienced hands, duration is a strong predictor of UM in patients undergoing TE. Examinations longer than 4 min are more likely to be unreliable. Examinations longer than 8 min are unlikely to yield a valid result and should be considered a futility endpoint. Older age and increased BMI and nonhepatitis B aetiology are independent, albeit weaker, predictors of UM.