Are non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1A gene associated with pre-eclampsia in the Finnish population?
The sequence variants in the exon 12 of the HIF1A gene were not associated with pre-eclampsia in the Finnish population.
Our study revealed an inverse relationship between urine aMT6s and arterial stiffness as determined by CAVI. Although it is impossible to determine causality, our results suggest that melatonin may have a beneficial role in the pathogenesis of atherosclerosis. Further prospective studies are required to establish the clinical significance of our study.