Does inhibition of Phosphatidylcholine-Specific Phospholipase C interfere with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma?
These data suggest that the inhibition of PC-PLC activity may represent a new therapeutic approach to selectively target the most aggressive and tumor promoting sub-population of floating spheres originated from squamous cancer cells possessing different proliferative and stemness potential.
Collectively, these findings underscore the importance of TNF-α and highlight the interaction between IL-6 and IL-1α to generate an inflammatory microenvironment in driving (PSMA,PSA) prostate clones.