Does β-Amyloid Burden predict Lower Extremity Performance Decline in Cognitively Unimpaired Older Adults?
In cognitively unimpaired older adults, Aβ burden overall and in specific brain regions are risk factors for lower extremity motor decline, independent of memory function. These findings provide the first empirical evidence that Aβ burden is a risk factor for mobility decline in older adults.
Our results indicate that lateral inhibition is mainly responsible for the interaction effect.