Does osteoprotegerin exert its pro-inflammatory effects through nuclear factor-κB activation?
These results indicate that OPG has pro-inflammatory properties because it induces gut barrier dysfunction and secretion of other pro-inflammatory cytokines. These results also provide evidence that OPG is likely to exert its pro-inflammatory effects through NF-κB activation and may potently contribute to IBD pathogenesis.
Methotrexate can be a steroid sparing agent in acute sarcoidosis.