Does overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induce a steatotic phenotype?
The induction of a steatotic phenotype implies that p62 plays a role in hepatic pathophysiology.
PGF is the major cause of early mortality after cardiac transplantation. Significant risks for PGF are long allograft ischemic time and increased donor age. Once the patient has survived 30 days, however, the longer-term survival is not influenced by PGF. Our management strategy of early mechanical support has yielded good outcomes in this population with a high risk of early death.