Does vagotomy attenuate brain cytokines and sleep induced by peripherally administered tumor necrosis factor-α and lipopolysaccharide in mice?
We conclude that vagal afferents mediate peripheral TNF-α-induced brain TNF-α and IL-1β mRNA expressions to affect sleep. We also conclude that vagal afferents alter sleep induced by peripheral pro-inflammatory stimuli in mice similar to those occurring in other species.
The changes shown could be important factors for the reduced mesenteric perfusion during sepsis.