Does early detection of ureteropelvic junction obstruction improve surgical outcome in terms of renal function?
We believe that patients who undergo prenatal imaging and are diagnosed early with ureteropelvic junction obstruction should be carefully and meticulously followed. Special efforts should be made to ensure that patients are not lost to followup. After any sign of deterioration develops early surgery is indicated. According to our data operative treatment results in improved renal function.
Sorafenib and DDP show a synergistic effect in inhibiting the proliferation and inducing apoptosis of HepG2 cells. The mechanisms of this synergistic effect can be closely related to the double blockage of the cell cycle and Raf/MEK/ERK pathway inhibition.