Does disruption of nNOS-PSD95 protein-protein interaction inhibit acute thermal hyperalgesia and chronic mechanical allodynia in rodents?
nNOS-PSD95 interaction is important in maintaining hypersensitivity in acute and chronic pain. Disruption of the nNOS-PSD95 interaction provides a novel approach to obtain selective anti-hyperalgesic compounds.
This study suggests that transfer of SOCS3 by an oncolytic adenovirus represents a potent approach for cancer therapy.