Is regulated and polarized PtdIns ( 3,4,5 ) P3 accumulation essential for apical membrane morphogenesis in photoreceptor epithelial cells?
Spatially localized PtdIns(3,4,5)P3 mediates directional sensing during neutrophil and Dictyostelium chemotaxis. We conclude that a conserved mechanism also operates during photoreceptor epithelial cell morphogenesis in order to achieve normal differentiation of the apical membrane.
The results indicate neural over-recruitment in healthy aging, which appears most likely linked to alterations in multiple factors associated with sensory and cognitive aspects of motor control, and which does not consistently or directly impact response speed.