Does simvastatin improve retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice?
This specific combination of behavioral measurements of visual function, cortical activity imaging, and histologic analyses is ideally suited to follow ischemia-induced changes and to monitor the effect of therapeutic approaches. Statin therapy may be a promising pharmacologic tool for the treatment of acute retinal ischemia in particular because, in our study, simvastatin was applied after ischemia, a treatment regimen with much greater clinical relevance than preventive administration, as in previous studies.
Taken together, these results demonstrate the ashwaganda WSE as a valid candidate for evaluation of therapeutic potential for the treatment of chronic renal dysfunction.