Does modelling clinical data show active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration?
Using plasma concentrations as surrogates for clinical recommendations may lead to substantial underestimation of the risk of resistance.
According to our finding that 85 Gy brought more rapid clinical improvement without causing more complications, 85 Gy seems to be preferable to 80 Gy, but prospective randomized trials are mandatory to get a more definite conclusion on the optimal dose for GKS of TN.