Does latrunculin-A cause mydriasis and cycloplegia in the cynomolgus monkey?
In monkeys, LAT-A causes mydriasis and cycloplegia, perhaps related to its known ability to disrupt the actin microfilament network and consequently to affect cell contractility and adhesion. Effects of LAT-A on the iris and CM may have significant physiological and clinical implications.
Even though the CVS is not exclusively found in MS-WMLs, SWI may be a useful adjunct in patients with possible MS.