Does upregulation of natural killer cells function underlies the efficacy of intratumorally injected dendritic cells engineered to produce interleukin-12?
Overall, these results point out an important role played by NK cell activation in the potent immunotherapeutic effects elicited by intratumoral injection of IL-12--secreting DC and that NK activation under these conditions is mainly, if not only, dependent on IL-12.
Although it is not an independent factor, thickness is a significant predisposing factor for lymph node metastasis.