Does antithrombin inhibit lipopolysaccharide-induced tumor necrosis factor-alpha production by monocytes in vitro through inhibition of Egr-1 expression?
These observations suggest that AT might inhibit LPS-induced production of TNF-alpha by inhibiting the increase in Egr-1 expression in monocytes via interaction with heparin-like substances expressed on the cell surface.
Herpes simplexvirus, especially HSV-1, may have a role in the causation of perforated duodenal ulcers.