Does hepatitis B virus X protein stimulate IL-6 expression in hepatocytes via a MyD88-dependent pathway?
In hepatocytes and hepatoma cells, HBx stimulates the production of IL-6 in a MyD88-dependent manner, indicating that parenchymal liver cells are an additional source of high levels of IL-6 in the HBV-infected liver microenvironment. HBx could be involved in HBV-mediated liver carcinogenesis, through this mechanism of action.
RA volume and reservoir function and their combined use with RVEF are novel predictors of CW in patients with pre-capillary PH.