Does tRPC6 channel protect retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death?
This study documents the pattern of TRPC6 expression in the retinal IR model and provides evidence that activating TRPC channels before ischemia has early neuroprotective effects on RGCs in vivo. The protection of TRPC6 is BDNF mediated, and proBDNF-p75(NTR) signaling may contribute to the death of RGCs in retinal ischemia injury.
The results showed that quality of evidence is a key determinant for making a strong vs. a weak recommendation.