Does [ Autocrine IL-1beta secretion lead to NF-kappabeta-mediated chemoresistance in pancreatic carcinoma cells in vivo ]?
The autocrine secretion of IL-1beta contributes to a constitutively increased NF-kappaB activity in PDAC cells along with a chemoresistant phenotype.
The protective effect of metformin against free fatty acid induced apoptosis is potentially clinically relevant as metformin is first line treatment for patients with T2D, a patient group which is rapidly increasing and carries a high burden of cardiovascular disease.