Are electrostatic interactions important for the distribution of Gd ( DTPA ) ( 2- ) in articular cartilage?
To obtain more accurate estimates of the fixed charge density using the dGEMRIC method, interionic interactions need to be taken into account in the Donnan analysis. Furthermore, the results suggest that the combination of μMRI dGEMRIC experiments and Monte Carlo simulations are useful tools for an improved understanding of these effects. Magn Reson Med 76:500-509, 2016. © 2015 Wiley Periodicals, Inc.
Taken together, these results reveal that each of the known H3K9me3-binding proteins is dispensable for SETDB1-mediated ERV silencing. We speculate that H3K9me3 might maintain ERVs in a silent state in mESCs by directly inhibiting deposition of active covalent histone marks.