Does rosiglitazone ameliorate diabetic nephropathy by inhibiting reactive oxygen species and its downstream-signaling pathways?
Rosiglitazone treatment prevented glomerular injury in diabetic rats, which was closely related with its roles of reducing reactive oxygen species, NF-kappaB activation and MCP-1 expression in the early phase of diabetic nephropathy.
The extract induced a significant decrease in the number of inflammatory cells. This effect is likely due to higher concentrations of tannins and phenolic compounds in the extract of plant. Thus this study provides a scientific validation of the use of this plant against asthma and cough in the Ivorian pharmacopoeia. However, its mechanism of action remains to be elucidated.