Do combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy?
This combination of agents causes an inhospitable microenvironment for tumor cells and shows great promise for use in the clinic.
Despite general genotype-related differences, we had to reject our hypothesis of an increased CNP induced lung inflammation and an impairment of its resolution in PPARγ defective mice. Although earlier studies showed ligand-induced activation of nuclear receptor PPARγ to promote resolution of lung inflammation, its reduced activity did not provide signs of resolution impairment in the settings investigated here.