Does treatment of obesity with diet/exercise versus pioglitazone have distinct effects on lipoprotein particle size?
In obese, insulin resistant non-diabetic adults, pioglitazone improved LDL particle characteristics in a manner similar to diet/exercise without changing TG, diabetic control, total or LDL cholesterol. This effect could have implications for atherosclerotic risk.
Increased Ca2+ influx through L-type voltage-dependent Ca2+ channels seems to be responsible for the sustained mechanical tone of proximal colon from mdx mice. The mechanisms for sequestering calcium appear to be unaltered.