Does alloimmunization to transfused platelets require priming of CD4+ T cells in the splenic microenvironment in a murine model?
We report a novel model to study antigen-specific CD4+ T cells during alloimmunization to PLT transfusion. The presented data support a critical role for CD4+ T-cell help in the humoral response to PLT transfusion and establish the spleen as a required microenvironment for effective CD4+ T-cell priming against donor PLT-derived MHC I.
H2O2 induces the expression of heat shock protein 27 in human lens epithelial cell line. The effects are mediated, at least in part, through the activation of P38MAPK signaling pathway.