Is time-of-intake ( morning versus evening ) of extended-release fluvastatin in hyperlipemic patients without influence on the pharmacodynamics ( mevalonic acid excretion ) and pharmacokinetics?
This study demonstrates that fluvastatin ER is equally effective in inhibiting cholesterol biosynthesis when given once daily in the morning and once daily in the evening.
These results support our hypothesis that reducing myocardial temperature reduces infarct size. However, it is important the reduction in temperature be produced as early as possible following coronary artery occlusion.