Does platelet-activating factor priming of inflammatory cell activity require cellular adherence?
PAF primes mononuclear cells by increasing Toll-mediated signaling only under adherent conditions. This, therefore, would limit PAF-induced priming in vivo to foci of stimulated adherent inflammatory cells with little effect systemically on circulating cells.
Alkannin can inhibit the growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway.