Do a systems approach to mapping transcriptional networks controlling surfactant homeostasis?
Within the transcriptional network, SREBP, CEBPA, FOXA2, ETSF, GATA6 and IRF1 were identified as regulatory hubs displaying high connectivity. SREBP, FOXA2 and CEBPA together form a common core regulatory module that controls surfactant lipid homeostasis. The core module cooperates with other factors to regulate lipid metabolism and transport, cell growth and development, cell death and cell mediated immune response. Coordinated interactions of the TFs influence surfactant homeostasis and regulate lung function at birth.
Women experienced slightly more second-degree tears when residents were involved in their deliveries. The increased number of second-degree tears might be because of residents' limited experience in providing intrapartum care. More important, there was no increase in other serious perineal trauma or episiotomy when residents provided supervised intrapartum care. This should reassure women and family practice obstetricians who choose to receive and provide obstetric care in a family practice teaching unit. The increase in rates of epidural use and cesarean sections and the decrease in rates of vacuum-assisted births reflect obstetric trends in Canada over the past decade.