Does the expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage cause impaired glucose homeostasis?
Our observations support a cell autonomous role for TCF7L2 in pancreatic β-cells suggested by most, though not all, investigations. βTCFDN is a novel model for further exploring the role of TCF7L2 in β-cell genesis and metabolic homeostasis.
The main factors which influenced the survival of patients treated by PEIT were: the size of the HCC, the Child-Pugh class, the Barcelona stage and the level of alpha-fetoprotein at the time of initiation of therapy.