Does streptomycin inhibit electrophysiological changes induced by stretching of chronically infarcted rat hearts?
Stretch-induced MAPD90 changes and arrhythmias were observed in chronically infarcted myocardium. The use of SM in vivo decreased the incidence of PVBs but not of VT. This suggests that SACs may be involved in mechanoelectric feedback (MEF), but that there might be other mechanisms involved in causing VT in chronic MI.
Our data identify laminin gamma-1 as a novel target to combat neurodegeneration.