Is chromatin decondensation accompanied by a transient increase in transcriptional output?
We propose a model whereby the initiation of transcription is not impaired in condensed chromatin, but inefficient elongation in these conditions leads to the accumulation of RNA polymerase II at the transcription site. Upon chromatin decondensation, release of the RNA polymerase II halt triggers a wave of transcription, which we detect as a transient spike in activity.
The introduction of a fast-track programme after primary LRYGB improves short-term recovery and may reduces direct hospital-related resources.