Are dimethylarginine dimethylaminohydrolase-1 transgenic mice protected from ischemic stroke?
Our study demonstrates that hDDAH-1 transgenic mice are not protected from ischemic cerebral tissue damage in tMCAO. This lack of protection is due to high basal cerebral DDAH activity, which is not further increasable by transgenic overexpression of DDAH.
These results do not support the routine use of T3 to enhance or accelerate onset of antidepressant response in patients with major depressive disorder.