Is anti-CCP2 an adjunct to , not a surrogate for , rheumatoid factor in the diagnosis of rheumatoid arthritis : diagnostic utility of anti-CCP2 antibodies in Egyptian patients with rheumatoid arthritis?
Anti-CCP2 has superior diagnostic and prognostic properties in RA compared with RF. It should not replace RF as a serological test; however, since using both tests modestly increases sensitivity and markedly enhances specificity, so that diagnosis of RA is highly probable when both tests are positive.
A high concentration of C3 is a marker of a profile at risk of atherogenesis.