Are aTF4 and the integrated stress response induced by ethanol and cytochrome P450 2E1 in human hepatocytes?
This study demonstrates that both CYP2E1 and ethanol induce ATF4 and the integrated stress response, a pathway which coordinates signals from multiple stresses, as well as established risk factors for ALD, and can display detrimental cellular effects upon prolonged activation.
Human hearts weighing 6-10 g have conduction times half that of the adult human heart which weighs 50 times as much. The contribution of the AV node to the total AV conduction time increases with diminishing heart size.