Does [ The Fc region of immunoglobulin suppress atherosclerosis in apolipoprotein E knockout mice ]?
Immunoglobulin therapy remarkably suppressed atherosclerosis due to Fc receptor-mediated anti-inflammatory action. The suppression of the disease is associated with remarkably reduction of macrophage density in the lesions, but not with the reduction of high serum lipid levels.
In this retrospective longitudinal study, we provide initial evidence that FA can recover within TAI lesions. However, FA recovery did not correlate with improved functional outcomes. Prospective histopathological and clinical studies are needed to further elucidate whether lesional FA recovery indicates axonal healing and has prognostic significance.