Does chymase inhibitor ameliorate eosinophilia in mice infected with Nippostrongylus brasiliensis?
Chymase released by activated mast cells may play a role in helminth-induced eosinophilia.
This study demonstrated distinct disparity between myotubes derived from lean compared with obese and obese diabetic individuals following gAd and AICAR treatment. Further understanding of the regulation of PDK4 in obese and diabetic skeletal muscle and its interaction with adiponectin signalling is required as this appears to be an important early molecular event in these disease states that may improve blood glucose control and metabolic flux.