Does the cyclooxygenase-2-765C promoter polymorphism protect against the development of chronic obstructive pulmonary disease?
The -765C allele, which has been shown to be associated with decreased promoter activity of the cyclooxygenase-2 gene, is more common in resistant smokers. This raises the possibility that decreased activity of cyclooxygenase-2 may protect smokers against the development of COPD.
Subepidermal moisture was associated with future (1 week later) PU in persons with dark skin tones. Subepidermal moisture threshold values may assist in detecting early PU in persons with dark skin tones, allowing for earlier intervention to prevent PU. These findings should be further evaluated in persons with dark skin tones.