Does nOTCH1 signaling promote human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches?
These results reveal a functional hierarchy within the LIC population based on NOTCH1 activation, which renders LIC susceptible to targeted NOTCH1 inhibition and highlights the utility of NOTCH1 antibody targeting as a key component of malignant stem cell eradication strategies.
LAG-3 negatively regulated the function of HCV-specific CD8(+) T cells in CHC patients.