Is partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis related to persistent nocturnal polyuria on wet nights?
Persistence of nocturnal polyuria on wet nights in partial desmopressin responders may be related to an insufficient antidiuretic effect. In addition to poor compliance and suboptimal dosing, the poor bioavailability of intranasal desmopressin may be a pathogenic factor. Further prospective studies are needed.
In this study, 8 of 9 patients had 95% to 100% coverage of an isolated acetabular chondral lesion or acetabular lesion associated with a femoral head lesion, with grade 1 or 2 appearance of the repair product at an average of 20 months follow-up. One patient who had diffuse osteoarthritis failed, with only 25% coverage with a grade IV appearance of the repair product 10 months after index arthroscopy.