Is large-conductance calcium-activated potassium channel activity , as determined by whole-cell patch clamp recording , decreased in urinary bladder smooth muscle cells from male rats with partial urethral obstruction?
Our findings show that obstruction of the rat bladder is associated with decreased Maxi-K channel activity of bladder smooth muscle cells, determined via direct current measurement. Increased expression of the β1 subunit points to a compensatory reaction to decreased Maxi-K channel activity. Maxi-K channel openers or gene therapy may therefore provide therapeutic benefit for the overactive bladder.
Anal fistulae plug was associated with a lower success rate than previously reported. Septic complications were the main reason for failure.