Are overexpression of CDC25B , CDC25C and phospho-CDC25C ( Ser216 ) in vulvar squamous cell carcinomas associated with malignant features and aggressive cancer phenotypes?
Our results suggest that CDC25C and phospho-CDC25C (Ser216) play a crucial role and CDC25B a minor role in the pathogenesis and/or progression of vulvar carcinomas. CDC25B, CDC25C and phospho-CDC25C (Ser216) were associated with malignant features and aggressive cancer phenotypes. However, the CDC25s isoforms were not independently correlated to prognosis.
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