Does calreticulin mediate an invasive breast cancer phenotype through the transcriptional dysregulation of p53 and MAPK pathways?
Besides confirming calreticulin overexpression in invasive breast cancer tissues, this study reveals a calreticulin-dependent pro-invasive potential and suggests possible contributing pathways. Defining the mechanistic role of invasion and characterizing the possible calreticulin-dependent molecular targets will be the focus of future work.
This analysis provides additional support for the ECA survey's prevalence estimate of late-life depression. This research failed to find evidence that the highly structured nature of the DIS makes it unsuitable for ascertaining symptoms of depression in the elderly.