Do gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function?
Minor allele carriers for E298D and i19342 have an impaired postprandial MEF and increased oxidative stress. Our results both provide insight into the higher risk of CVD attributed to E298D and identify variants that affect MEF in a healthy population.
The findings obtained increase the knowledge on the mode of action of rosiglitazone in promoting the survival of MHC Class II-mismatched cardiac transplants in which the CD8 T cells and eosinophils play key roles. PPAR-γ signaling combined with IL-5 blockade prevents graft rejection.