Are dietary intake patterns reflected in metabolomic profiles : potential role in dietary assessment studies?
Habitual dietary patterns are shown in metabolomic data. This approach successfully identified potential biomarkers of red-meat and vegetable intakes.
In NASH patients, hepatic PPAR-γ induction by rosiglitazone was associated with increased hepatic expression of pro-inflammatory genes which may explain the lack of long-term histological benefit shown in human studies with this drug. It is unclear whether these results are a class effect of PPAR-γ agonists or a specific effect of rosiglitazone.