Are mutations in the gene encoding paired box domain ( PAX8 ) a frequent cause of congenital hypothyroidism ( CH ) in Iranian patients with thyroid dysgenesis?
Our results, once again, indicate that the PAX8 mutation rate is very low and can only explain a minority of the cases. Therefore, it is highly needed to further investigate the genes controlling development and function of thyroid.
Our results suggest that HT22 cells possess functional cholinergic properties, and can be used for an in vitro model for defining the mechanisms in cognitive deficits of Alzheimer's disease.