Do gene conversion events between GYPB and GYPE abolish expression of the S and s blood group antigens?
The three GYPB-E-B hybrid genes reported here constitute the first evidence of recombination events between GYPB and GYPE. As these GYPB-E-B hybrid genes drive the S-s- blood phenotype, it is important to know they are a limitation for the current blood group genotyping methods, including those performed by commercial platforms.
Although more complex in design, ASDs have the potential to be more efficient and more powerful than conventional designs.