Does whole genome methylation array analysis reveal new aspects in Balkan endemic nephropathy etiology?
Our data propose a new hypothesis that immunologic dysregulation has a place in BEN etiopathogenesis.
MD-354 selectively antagonizes the antinociceptive actions of (-)nicotine in the tail-flick, but not in the hot-plate assay, or either the motor effects, or discriminative stimulus effects of (-)nicotine. The most parsimonious explanation is that MD-354 might act as a negative allosteric modulator of alpha 7 nACh receptors, and radioligand binding and functional data are provided to support this conclusion.