Is curcusone D , a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition , synergistic with bortezomib against multiple myeloma cell growth?
Curcusone D is novel UPP inhibitor that acts via the ROS-induced inhibition of DUBs to produce strong growth inhibition and apoptosis of MM cells and synergize with bortezomib.
home rehabilitation for frail elderly after acute hospitalisation is a viable option for selected patients and is associated with a lower risk of delirium, greater patient satisfaction, lower cost and more efficient hospital bed use.