Is chromosomal instability associated with global DNA hypomethylation associated with the initiation and progression of esophageal squamous cell carcinoma?
Our results suggested that whole genome hypomethylation caused by chronic inflammation could initiate carcinogenesis of esophageal squamous cells through chromosomal instability. In addition, chromosomal instability associated with the global hypomethylation might correlate highly with the progression of ESCC.
These results indicate that mast cells are involved in the pathogenesis of the intestinal mucosal damage induced by indomethacin.