Does chemokine ( C-C motif ) receptor 2 mediate mast cell migration to abdominal aortic aneurysm lesions in mice?
The increased AAA formation and associated lesion characteristics in Apoe(-/-)Kit(W-sh/W-sh) mice after receiving BMMC from Apoe(-/-) mice, but not from Apoe(-/-)Ccr2(-/-) mice, suggests that mast cells use CCR2 as the chemokine receptor for their recruitment in Ang II-induced mouse AAA lesions.
The higher percentage of smoking cessation was achieved using multiple therapies (counseling + NRT + bupropion). The only significant predictor of failure detected was severe nicotine dependence.