Do exogenous insulin requirements differ between youth and adults with cystic fibrosis related diabetes?
Modest insulin requirements suggest the persistence of endogenous insulin secretion in both youth and adults with CFRD. In adolescents, residual endogenous insulin secretion likely compensates for the insulin resistance during puberty, keeping insulin requirements low.
Our results suggest that the higher prevalence of obesity among black women plays an important role in explaining their relative disadvantage in stage at diagnosis of breast cancer. Nonetheless, a racial difference in stage of breast cancer at diagnosis persists after adjustment for obesity.