Does overexpression of a mutant form of TGFBI/BIGH3 induce retinal degeneration in transgenic mice?
Cellular degeneration in the retina of transgenic animals suggest that perturbation of the transforming growth factor beta (TGFbeta) family regulation may affect photoreceptor survival and may induce possible accelerated aging in several tissues. No corneal phenotype could be observed, probably due to the lack of transgene expression in this tissue.
Low-volume exercise rehabilitation can improve activity of daily living-related functional capacity and self-reported functional status of nonanemic dialysis patients.