Does the location of hepatocytes in the rat liver acinus determine their sensitivity to calcium-mobilizing hormones?
Hepatocyte location in the acinus determines cellular sensitivity to Ca(2+)-mobilizing agonists. Intercellular Ca2+ waves in the liver could be driven by sensitivity gradients along the hepatocyte plate.
Piroxicam treatment had no beneficial effects on the chronic stable inflammation in this model and might even delay histological resolution. As the anti-inflammatory effect of piroxicam is restricted to acute inflammation, the use of NSAIDs during periods of chronic stable arthritis in humans, such as in RA, may need to be investigated.