The determinants of excellent health: different from the determinants of ill-health?
The processes by which excellent health is generated probably have much in common with those which generate ill-health. At the same time it is obvious that our understanding of the determinants of ill-health is better than that of the determinants of excellent health, and further study of the latter is recommended.
YY1 is overexpressed in fibroblasts in both human IPF and murine models in a NF-κB-dependent manner, and YY1 regulates fibrogenesis at least in part by increasing α-SMA and collagen expression. Decreasing YY1 expression may provide a new therapeutic strategy for pulmonary fibrosis.