Is the small cell lung cancer-specific isoform of RE1-silencing transcription factor ( REST ) regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa ( nSR100 )?
The splicing factor nSR100 may be novel SCLC-specific biomarker, as well as a therapeutic target.
These findings indicate that the repression of TNF-alpha associated with moderate hypothermia during cardiac surgery is associated with inhibition of the mitogen-activated protein kinase p38/activating protein-1 pathway and not with inhibition of NF-kappaB. The use of moderate hypothermia during cardiac surgery may mitigate the perioperative systemic inflammatory response and its complications.