Do collagen barrier membranes decrease osteoclastogenesis in murine bone marrow cultures?
These in vitro findings demonstrate that CBM can reduce the formation but not the activity of multinucleated osteoclasts. Our data further reveal that the formation of osteogenic cells from their progenitors is not reduced by the CBM. Overall, our results suggest that the beneficial effects of CBM during graft consolidation may involve their direct impact on osteoclastogenesis.
Our findings suggest that interpersonal functioning deficits are in some regards a stable feature among people with a history of depression; however, they possess temporary features as well. Depression may scar interpersonal functioning, but only if it occurs early in life.