Does hemofiltration influence early S-100B serum levels in septic shock patients receiving stress doses of hydrocortisone or placebo?
Early S-100B serum levels in septic shock patients receiving either stress doses of hydrocortisone or placebo were not influenced by CVVH. For the first time, we observed a similar extent of S-100B serum increase in CVVH patients, who had significantly higher S-100B serum values compared to those without CVVH, as reported for out-of-hospital cardiac arrest or severe traumatic brain injury. Hypercortisolemia induced by the infusion of stress doses of hydrocortisone did not significantly reduce early S-100B serum concentrations with time.
These findings suggest that elevated plasma levels of CRP are associated with subsequent allograft failure in cardiac transplant recipients.