Are acetylcholinesterase and butyrylcholinesterase expressed in the spinal meninges of monkeys and pigs?
These data show that the spinal meninges express acetylcholinesterase and butyrylcholinesterase; for monkeys, although not pigs, the level of cholinesterase activity is comparable with that found in the spinal cord. This finding suggests that the meninges may be an important site for acetylcholine metabolism and may play a role in the analgesic effect produced by intrathecally administered cholinesterase inhibitors.
Our findings provide evidences for the involvement of rs1801133 in the development of NSCL/P in the Brazilian population.