Is hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 required to promote the angiogenic phenotype in uveal melanoma?
Targeting both ANGPTL4 and VEGF may be required for the effective inhibition of angiogenesis in UM.
These results indicated that NZ inhibited the generations of NO and pro-inflammatory cytokines by suppressing TLR4/MyD88/NF-κB pathway, suggesting that NZ could be an effective candidate for ameliorating LPS-induced inflammatory responses.