Does propofol facilitate glutamatergic transmission to neurons of the ventrolateral preoptic nucleus?
Propofol induces sedation, at least in part, by increasing firing of GABAergic neurons in the VLPO, indirectly by activation of GABA(A) receptors on glutamatergic afferents: Because these axons/terminals have a relatively high internal Cl concentration, they are depolarized by GABAergic agents such as propofol, which thus enhance glutamate release.
Hypertrophy of multifidus occurred over a 3 month period during which dynamic mobilisation exercises were the only exercise performed.