Do molecular dynamics approach to probe PKCβII-ligand interactions and influence of crystal water molecules on these interactions?
The study showed that the nonbonding interactions contribute significantly in PKCβII-ligand binding and presence of crystal water molecules affects the interactions. The findings of present work may integrate the new aspects in the drug design process of PKCβII inhibitors.
Compared with healthy individuals, both global and intracortical transcranial magnetic stimulation measures reveal reduced motor cortex excitability in survivors of stroke. Interventions that normalize motor cortex excitability may promote better neurophysiological conditions for motor recovery to occur.