Does deletion of the GABAA α2-subunit alter self administration of cocaine or reinstatement of cocaine seeking?
Despite a reported absence of sensitisation, motivation to obtain cocaine remains unchanged in KO and HT mice. Reinstatement of cocaine seeking by cocaine and cocaine-paired cues is also unaffected. We postulate that whilst not directly involved in reward perception, the α2-subunit may be involved in modulating the "energising" aspect of cocaine's effects on reward-seeking.
HAV seropositivity is associated with slower psychomotor speed among the U.S. community-dwelling elders.