Do anesthetics affect the uptake but not the depolarization-evoked release of GABA in rat striatal synaptosomes?
These results indicate that most of the intravenous but not the volatile anesthetics inhibit the specific high-affinity 3H-GABA uptake process in vitro in striatal nerve terminals. However, this action was observed at clinically relevant concentrations only for propofol and etomidate. In contrast, the depolarization-evoked 3H-GABA release was not affected by anesthetics. Together, these data suggest that inhibition of GABA uptake, which results in synaptic GABA accumulation, might contribute to propofol and etomidate anesthesia.
The 2-thumb-encircling hands technique can produce a compression depth meeting the current guidelines recommendation without negative influence on ventilation, whereas the TF technique cannot. The 2-thumb-encircling hands technique generates a significant higher ratio of correct compression position than the TF technique. Furthermore, the 2-thumb-encircling hands technique is less fatiguing than the TF technique.