Does lens intrinsic membrane protein MP19 contain a membrane-targeting signal?
It appears that the first 25 amino acids of the MP19 molecule are sufficient to target the protein to the cell membrane, and apparently integrate into the membrane. With the addition of more amino acids, the polypeptide distributes in the membrane similarly to that of the intact MP19 molecule. It appears that the first 25 amino acids of the MP19 molecule is, indeed, a membrane signal and integration sequence. Also, at least part of these 25 amino acids must integrate into the cell membrane, but not extend through the cell membrane.
We evaluated the symptoms, perioperative ECG changes, and cardiac troponin I and CK-MB plasma levels in patients who underwent SWL for renal stones and did not identify any myocardial damage. Troponin I plasma levels were not elevated after this procedure and, therefore, remain suitable for evaluation of patients complaining of chest pain after SWL.