Does minocycline reduce reactive gliosis in the rat model of hydrocephalus?
Minocycline treatment is effective in reducing the gliosis and delaying the development of hydrocephalus with prospective to be the auxiliary therapeutic method of hydrocephalus.
To answer our provocative title "Pedicle screw instrumentation have we gone too far?" Definitively we can answer that for some spinal deformities instrumented with all-pedicle-screw instrumentation, we have observed cases where the surgeons have gone way too far; in other cases, where such instrumentation was used in a comprehensive and rational manner, the answer to "Have we gone too far" is no, and such use of pedicle screw has improved outcome with minimum complications.