Is expression of toll-like receptors 2 and 4 upregulated during hospital admission in traumatic patients : lack of correlation with blunted innate immune responses?
These results indicate that trauma patients present a dysregulation of the innate immune system that persists during the first 14 days after hospital admission.
We found that TLX1 and NOTCH synergistically regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of MYC. We conclude that the TLX1/NOTCH/MYC network is a central determinant promoting the growth and survival of TLX1+ T-ALL cells. In addition, the TLX1/NOTCH/MYC transcriptional network coregulates genes involved in T cell development, such as CD1 and RAG family members, and therefore may prescribe the early cortical stage of differentiation arrest characteristic of the TLX1 subgroup of T-ALL.