Is presence of circulating Her2-reactive CD8 + T-cells associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells , and better survival in older breast cancer patients?
Our data demonstrate a negative role of both MDSCs and Tregs in the prognosis of breast cancer patients, the mechanism of which might be through dampening favourable CD8+ T cell immune responses to tumour-associated antigens.
Ineffective erythropoiesis of in vitro cultured beta-thalassemic cells is likely related to impaired cell maturation. KCC activity appears to contribute to erythroid cell growth during late erythropoiesis.