Is the severity of periodontitis related to gingival crevicular fluid and serum high-sensitivity C-reactive protein concentrations?
IL-1β in GCF could be a marker of disease severity and activity. Neither serum nor GCF levels of hs-CRP differed with disease severity. Serum hs-CRP levels did not reflect GCF levels in periodontitis patients. Local and systemic involvement of CRP in periodontal disease remains to be determined.
These data indicate that MWA, anxiety disorders, and major depression can be components of a distinct clinical syndrome associated with allelic variations within the DRD2 gene. Clinical recognition of this genetically based syndrome has significant diagnostic and therapeutic implications.