Does retroviral expression of human arginine decarboxylase reduce oxidative stress injury in mouse cortical astrocytes?
Our findings imply that astrocytes can be reinforced against oxidative stress by endogenous agmatine production through ADC gene transduction. The results of this study provide new insights that may lead to novel therapeutic approaches to reduce cerebral ischemic injuries.
Our results demonstrate the importance of Apelin-13 in amelioration of aortic oxidative stress, adventitial remodeling and fibrosis in hypertensive rats with TAC via modulation of the mTOR/ERK signaling, thus indicating potential therapeutic strategies by enhancing Apelin/APJ action for preventing hypertensive vascular adventitial remodeling and fibrosis and pressure overload-associated cardiovascular disorders.