Do rat bone marrow mesenchymal stem cells differentiate into hepatocytes in vitro?
The method combining gradient density centrifugation with plastic adherence can isolate MSCs. Rat MSCs may be differentiated into hepatocytes by FGF-4 and HGF. Cytokines may play a more important role in differentiation from rat MSCs into hepatocytes.
These results demonstrate that canine PNP closely correlates to the human counterpart and may therefore represent an excellent model for the human disease.