Is major depression in young girls related to altered cortisol awakening response?
A causal interpretation of the data is restricted, because of its cross-sectional nature. The effect size of the mean differences is rather small.
We developed a sensitive method to analyze SNAP-25 levels in individual CSF samples that to our knowledge was not possible previously. Our results support the notion that synaptic biomarkers may be important tools for early diagnosis, assessment of disease progression, and to monitor drug effects in treatment trials.