Does dengue virus serotype infection specify the activation of the unfolded protein response?
This report provides evidence that Dengue infection induces and regulates the three branches of the UPR signaling cascades. This is a basis for our understanding of the viral regulation and conditions beneficial to the viral infection. Furthermore, modulators of UPR such as Salubrinal that inhibit Dengue replication may open up an avenue toward cell-protective agents that target the endoplasmic reticulum for anti-viral therapy.
The survival of 3-unit FPDs over a 20-year period is favorable and should be compared with other single-tooth replacement treatment options. There is an indication that the occurrence of a reversible complication has a predictive value for an irreversible complication later on.