Are tumours with loss of MSH6 expression MSI-H when screened with a pentaplex of five mononucleotide repeats?
these results show that the pentaplex assay efficiently discriminates the MSI status of tumours with an MSH6 defect.
The findings suggest that environmental risks for psychosis act additively, and that the level of environmental risk combines synergistically with non-clinical developmental expression of psychosis to cause abnormal persistence and, eventually, need for care.