Does galanin negatively modulate opiate withdrawal via galanin receptor 1?
Opiate administration and withdrawal increase galanin expression in the LC. Galanin opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1.
Addition of a PPI to celecoxib conferred extra protection for patients ages>/=75 years. PPI did not seem necessary with celecoxib for patients ages 66-74 years.