Does histamine produce opposing effects to serotonin in the knee joint of rats?
The present study revealed an antinociceptive mechanism that has previously not been detected by traditional nociceptive tests. Our observations may help to improve the development of new pharmacological strategies for the treatment of clinically relevant pains that generally originate in deep structures.
As females aged and self-reported health status comparisons declined, their depressive symptoms increased steadily, but at a lower rate than males' depressive symptoms. Older persons in fair or poor self-reported health should especially be screened for increasing depressive symptoms. Although females generally report greater risk of high depressive symptoms, it is still a concern for males as they age and their health declines.