Are pGC-1alpha downstream transcription factors NRF-1 and TFAM genetic modifiers of Huntington disease?
These results underscore that impairment of mitochondrial function plays a critical role in the pathogenesis of HD and that upstream transcriptional activators of PGC-1alpha may be useful targets in the treatment of HD.
MDE recurrence strongly depended on the number of preceding episodes. Those at highest risk of recurrence can be easily identified by their number of past episodes.