Does activation of phospholipase C gamma 1 protect renal arteriolar VSMCs from H2O2-induced cell death?
H2O2 increased PLCgamma1 expression and almost doubled total PLC activity, changes abolished by catalase. We conclude that H2O2 is cytotoxic to cultured VSMCs of renal preglomerular arterioles, a process that is attenuated by compensatory increases in PLCgamma1 protein level, tyrosine phosphorylation of PLCgamma1 and PLC enzymatic activity to generate IP3.
HRQoL was associated with physical fitness, especially aerobic fitness, and to a lesser extent with reported physical activity. These findings underline the importance of physical fitness for HRQoL in CF and provide an additional rationale for exercise testing in this population.