Does whole genome sequencing of Ethiopian highlanders reveal conserved hypoxia tolerance genes?
Our study reveals evolutionarily conserved genes that modulate hypoxia tolerance. In addition, we show that many of our results would likely be unattainable using data from exome sequencing or microarray studies. This highlights the importance of whole genome sequencing for investigating adaptation by natural selection.
We found no evidence to support the idea that changes in physical activity are a gateway for changes in dietary factors in middle-aged and older adults.