Does pyrophosphorolysis-activated polymerization detect circulating tumor DNA in metastatic uveal melanoma?
Bi-PAP assays detect and quantify ctDNA in patients with metastatic uveal melanoma. A prospective study is ongoing to assess the clinical usefulness of ctDNA level in uveal melanoma.
Optical coherence tomography thickness measurements of both pRNFL and mIRL are influenced by image degradation caused by optical density filters as a model for media opacities. An underestimation of the thickness of these layers was observed, caused by a shift of retinal layer boundary placement due to image quality loss. This underestimation is not the same for each individual and also differed between the pRNFL and mIRL thickness measurements. These individual and interindividual differences demonstrate that an individual approach will be necessary to correct for this underestimation per layer.