Is it safer to intubate premature infants in the delivery room?
The success of ENCPAP improved with increased GA and with staff experience over time. Infants treated successfully with ENCPAP were unlikely to develop intraventricular hemorrhage of grade III or IV. Infants who experienced ENCPAP failure were at increased risk for the development of necrotizing enterocolitis. Infants who were intubated briefly in the DR were at increased risk for prolonged oxygen requirement. An individualized approach should be considered for respiratory support of VLBW infants.
These results show that the distribution of circulating insulin-like growth factor I between its binding proteins 1 and 3 is altered in essential hypertension. Thus, there is a subgroup (53%) of hypertensive patients with increased serum levels of insulin-like growth factor I-binding protein 1. Access of the circulating factor to tissues is more easily achieved in these patients. The clinical characteristics of this subgroup of patients suggest that the tissue availability of insulin-like growth factor I is a determinant of organ damage and insulin sensitivity in essential hypertension.