Do hyperglycemia and oxidized-LDL exert a deleterious effect on endothelial progenitor cell migration in type 2 diabetes mellitus?
Hyperglycemia and elevated circulating OxLDL in DM patients with CAD severely impair EPC migration. These results suggest that the underlying mechanism for this impaired EPC migration is linked to the CXCR4/Pi3K/Akt/eNOS signaling pathway.
There is divided opinion on managing the acute presentation of terminal ileal Crohn's disease. Surgeons appear more conservative in their approach compared to gastroenterologists. This merits further clarification before acceptance amongst the majority of physicians and particularly surgeons.