Does ghrelin hyporesponsiveness contribute to age-related hyperinflammation in septic shock?
These findings suggest that the reduced central (brain) responsiveness to ghrelin due to the decreased GH, plays a major role in producing the hyperinflammatory state, resulting in severe organ injuries and high mortality after endotoxemia in aged animals. Ghrelin and GH can be developed as a novel therapy for sepsis in the geriatric population.
The results of this in vitro study suggest that the precise selection and placement of attachments may affect the clinical success of maxillary implant-retained overdentures.