Does urocortin attenuate myocardial fibrosis in diabetic rats via the Akt/GSK-3β signaling pathway?
These results suggest that urocortin exhibits a therapeutic benefit in the treatment of DCM by attenuating fibrosis and inflammation. Furthermore, inhibition of the Akt/GSK-3β signaling pathway may be partially responsible for these effects.
The maintenance of a scalar-linear increase in RPE by the brain remains the primary mechanism for pace regulation during both single and multi-modal endurance performance, with physiological responses being only indirectly related to this process. The apparent absence of any RPE 'resetting' between disciplines suggests that during shorter distance multi-sport performances (60-90 min) a cognitive pacing strategy for the entire event is employed. However, as subtle alterations in RPE development between disciplines were observed the existence of discipline-specific RPE 'templates' should not be discounted.