Does targeting galectin-1 in carcinoma-associated fibroblasts inhibit oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression?
Our findings demonstrate that Gal-1 regulates CAF activation and indicate that targeting Gal-1 in CAFs inhibits OSCC metastasis by modulating MCP-1 expression.
Inhibition of pulmonary NF-κB activity by IκBα overexpression reduced the severity of VILI in a rat model.