Do identification of UQCRB as an oxymatrine recognizing protein using a T7 phage display screen?
In this study, using the T7 phage display system, we have identified UQCRB as a direct binding protein of oxymatrine. Furthermore, the specificity and molecular interaction of oxymatrine with UQCRB were also determined. The binding of UQCRB to oxymatrine suggests that UQCRB is a potential target of oxymatrine in treating CHB. These results provide new understanding into the mechanism of oxymatrine and insights into the strategy on the treatment of CHB.
Our data suggest that the clinician's gaze significantly affects the medical encounter but that the converse is not true.