Is human drug-induced liver injury severity highly associated with dual inhibition of liver mitochondrial function and bile salt export pump?
These data affirm that severe manifestations of human DILI are multifactorial, highly associated with combinations of drug potency specifically related to known mechanisms of DILI (like mitochondrial and BSEP inhibition), and, along with patient-specific factors, lead to differences in the severity and exposure thresholds associated with clinical DILI.
Findings shed light on the utility of positive expectancies in predicting concurrent and subsequent hazardous alcohol use among female student-athletes. Future research directions and potential implications for prevention efforts are discussed.