Does differential proteomic analysis highlight metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations?
In the two chemostat conditions, used to generate biomass for proteomic analysis, mycelia grew with the same rate and with similar glucose-biomass conversion efficiencies. Global gene expression analysis revealed a differential metabolic adaptation, highlighting strategies for energetic supply and biosynthesis of metabolic intermediates required for biomass production and, in LP, for balhimycin biosynthesis. These data, confirming a relationship between primary metabolism and antibiotic production, could be used to increase antibiotic yield both by rational genetic engineering and fermentation processes improvement.
A flexible endoscopy robotic system can be used to perform ESD and effectively treat patients with early gastric neoplasia.