Is toll-like receptor 2 signaling a mediator of apoptosis in herpes simplex virus-infected microglia?
We demonstrate here that HSV induces an apoptotic response in microglial cells which is mediated through TLR2 signaling.
These findings provide evidence that KLF4 plays an important role in the pathophysiology of TBI. Blocking KLF4 may be a potential therapeutic strategy for the treatment of TBI, either alone or in combination with agents that target complementary mechanisms.