Does vitamin D insufficiency affect bone mineral density response to raloxifene?
We conclude that vitamin D status at initiation of raloxifene therapy does not affect the subsequent BMD response when coadministered with cholecalciferol and calcium. After 7 months of cholecalciferol therapy, very few women continued to have 25OHD levels in the deficient range; however, 25OHD levels remained suboptimal in nearly one fourth of the cohort. Additional research is needed to determine whether these observations can be generalized to other antiresorptive agents.
The results confirmed the hypothesis that fibers oriented toward the vertical plane reduce disk and fiber stresses and disk bulging. By aligning annular fibers toward the vertical plane axial distraction may help reduce disk and fiber stresses. Axial disk stresses decrease radially from outside to inside under compressive loading and that the anterior annulus is more stressed than the posterior-lateral annulus during both compression and distraction. Stresses decreased in both the annulus tissue matrix and fibers with increasing fiber angles and increasing fiber slope to 90 degrees (vertical fibers) is further anticipated to reduce the compressive disk stresses. The fibers in tension apply compression to the annulus tissue matrix, thus, decreasing annulus stresses in the axial and circumferential directions.