Does endothelin-a receptor antagonist treatment improve the periosteal microcirculation after hindlimb ischemia and reperfusion in the rat?
ET-1 plays a major role in microvascular dysfunction in the periosteum during reperfusion. The ET-1-ET-A receptor system might be an important target for tissue salvage therapy in transplantation surgery.
The results suggested that RER-positive phenotype was an early event in tumorigenesis through superficial elevated type adenomas.