Does sH3BP2 gain-of-function mutation exacerbate inflammation and bone loss in a murine collagen-induced arthritis model?
Gain-of-function of SH3BP2 augments inflammation and bone loss in the CIA model through increased macrophage activation and osteoclast formation. Therefore, modulation of the SH3BP2 expression may have therapeutic potential for the treatment of rheumatoid arthritis.
UKA was more precise using a semiactive robotic system with dynamic bone tracking technology compared to the manual technique.