Is the role of serum adipocyte fatty acid-binding protein on the development of metabolic syndrome independent of pro-inflammatory cytokines?
Baseline serum FABP4 levels appear to be a significant predictor for the future development of MetS, independent of pro-inflammatory cytokines.
In summary, short-term therapy with either tacrolimus or sirolimus causes insulin resistance in normal rats. Combination tacrolimus-sirolimus causes greater islet changes suggesting early islet failure.