Is the effect of the expression of angiotensin II on extracellular matrix metalloproteinase inducer ( EMMPRIN ) in macrophages mediated via the AT1/COX-2/PGE2 pathway?
Ang II can up-regulate EMMPRIN expression in THP-1 macrophages via the AT(1)/COX-2/PGE(2) signal transduction pathway, and the effect can be inhibited by losartan and NS-398.
Based on the findings of this study, we recommend that the concept of 'clinico-radiologico paradox' in multiple sclerosis be extended to CROP-'clinico-radiologico-ophthalmological paradox'. Furthermore, OCT data of MS patients should be interpreted with caution.