Do bile acids regulate nuclear receptor ( Nur77 ) expression and intracellular location to control proliferation and apoptosis?
These findings establish a direct link between Nur77 and the carcinogenic effect of BAs.
Spironolactone prevents the decrease in eNOS in the LV and aorta and improves NO-dependent vasorelaxation, suggesting that one potential mechanism of spironolactone is an improvement in vasoreactivity mediated though an increase in NO.