Does polymorphism of the transforming growth factor-beta 1 gene correlate with the development of coronary vasculopathy following cardiac transplantation?
This study demonstrates a correlation between a high-producing TGF-beta1 genotype and an earlier onset of cardiac-transplant coronary vasculopathy. This gives an important insight into the pathophysiology of cardiac transplant vasculopathy and suggests new treatment options.
Pulse pressure is a risk factor for stroke among normotensive individuals with systolic blood pressure below 140 mmHg, which suggests that pulse pressure may be useful to predict the risk of stroke among middle-aged nonsystolic hypertensive patients.