Does c4b-binding protein ( C4BP ) inhibit development of experimental arthritis in mice?
Although human C4BP was cleared relatively fast from the circulation and was only moderately affecting complement activity, its effect on the disease severity was substantial, suggesting that minor alterations in complement activity can have significant therapeutic value in RA.
The abnormality of metabolic factors in type 2 diabetes mellitus had a close relationship to the microinflammatory state and chronic kidney disease. Hypertension and hyperlipidemia were independent factors of chronic kidney disease in type 2 diabetes mellitus.