Is ordinal scoring of coronary artery calcifications on low-dose CT scans of the chest predictive of death from cardiovascular disease?
Visual assessment of CAC on low-dose CT scans provides clinically relevant quantitative information as to cardiovascular death.
MTAP activity is frequently lost, and ODC activity is frequently elevated in both pancreatic adenocarcinoma and neuroendocrine tumors. Inhibition of ODC activity caused decreased cell growth and increased apoptosis in pancreatic tumor-derived cell lines. These findings suggest that MTAP and polyamine metabolism could be potential therapeutic targets in the treatment of pancreatic cancer.