Does stability of cytadherence-related proteins P140/P110 in Mycoplasma genitalium require MG218 and unidentified factors?
Expression of truncated MG218 in M. genitalium mg218 mutants appears to be due to the presence of a putative promoter upstream to the point of mg218 disruption; this truncated protein possesses the C-terminal region of MG218. However, pulse chase results from spontaneously arising, non-cytadhering P140-deficient M. genitalium mutants suggest that the stability of P140 and P110 requires not only MG218 but also additional factors.
High NLR (≥4) before initiating ipilimumab treatment in patients with metastatic melanoma is an independent prognostic indicator of poor survival.