Does impaired coupling of local and global functional feedbacks underlie abnormal synchronization and negative symptoms of schizophrenia?
Our study implicates that patients with schizophrenia might have the impaired coupling of inter- and intra-regional functional feedbacks and that the CLGF circuit might serve as a critical bridge between abnormal synchronization and the negative symptoms of schizophrenia.
In trying to prevent early adolescents from alcohol and tobacco use, it might be of key importance to acknowledge the mutual influence between certain personality profiles and substance use. Specifically, sensation seeking and impulsivity are relevant during early adolescence and awareness of early adolescents' vulnerability for these personality predispositions is warranted.