Is the Pathological Response to Anthracycline Associated with Topoisomerase IIα Gene Amplification in the HER2 Breast Cancer Subset?
TOP2A amplification could predict anthracycline-sensitivity. Thus, the HER2/TOP2A co-amplified subtype may be effectively treated by anthracycline-containing regimens alone.
Loss of PTEN expression is associated with poor DFS and OS in patients with AA after curative surgery. PTEN expression may be used as a prognostic marker for patients with resected AA.