Is evolutionary pressure on mitochondrial cytochrome b consistent with a role of CytbI7T affecting longevity during caloric restriction?
Our results suggest the relationship between caloric restriction and increased longevity in human mitochondrial haplogroup H is determined by cytbI7T which likely enhances the ability of water to replenish the Q(i) binding site and decreases the time ubisemiquinone is at the Q(o) site, resulting in a decrease in the average production rate of radical oxygen species (ROS).
Our novel findings demonstrate that NPD1 treatment could represent a valuable therapeutic approach to control SK lesions.