Does heredity for hypertension influence intra-uterine growth and the relation between fetal growth and adult blood pressure?
Our results suggest that genetic factors contributing to the development of hypertension may influence intra-uterine growth.
The RyR2 central domain, expressed as a 'correctly' folded recombinant protein, bound ATP in accord with bioinformatics evidence of conserved ATP binding sequence motifs. An interaction with FKBP12.6 was not evident. CPVT mutations did not disrupt the secondary structure nor binding to ATP.