Are corticotropin-releasing hormone receptor 1 ( CRH-R1 ) polymorphisms associated with irritable bowel syndrome and acoustic startle response?
These findings support that CRH-R1 contributes to the dysregulated stress responsiveness in IBS.
Atrophy of the heart, secondary to mechanical unloading, is associated with early activation of the UPP. The simultaneous activation of the mTOR pathway suggests active remodeling, involving both protein synthesis and degradation.