Do expression of hypoxia-inducible factors in human endometrium and suppression of matrix metalloproteinases under hypoxic conditions support a major role for hypoxia in regulating tissue breakdown at menstruation?
These results do not support a role for hypoxia in the focally increased production and activation of MMP observed prior to and during menstruation.
While these databases have been commonly used for orthopaedic trauma research, differences in the populations they represent are not always readily apparent. Care must be taken to understand fully these differences before performing or evaluating database research, as the outcomes they detail can only be analysed in context.