Is isoform-dependent cholesterol efflux from macrophages by apolipoprotein E modulated by cell surface proteoglycans?
The present study clarified the differential cellular cholesterol-modulating effect of apoE isoforms in macrophages, which would be due to the difference in their binding to proteoglycans.
Our results suggested that miR-378 enhanced cell migration and metastasis by down-regulating Fus expression.