Is sero-reactivity to microbial components in Crohn 's disease associated with disease severity and progression , but not NOD2/CARD15 genotype?
Reactivity to microbial components is associated with severe CD characterized by small bowel involvement, frequent disease progression, longer disease duration, and greater need for intestinal surgery.
Interventions which relieve depression and pain improve daily functioning and QOL among patients with MDD. The proposed model can provide quantitative estimates of improvement in treating patients with MDD.