Is glutathione S-transferase pi upregulated in the stromal compartment of hormone independent prostate cancer?
The current results suggest that prostate cancer cells induce an injury response in the stroma during progression to hormone independence, which results in GST pi expression. Stromal GST pi may contribute to chemoresistence of advanced prostate cancer.
This suggests that other factors, with or without these miRNAs, are involved in mediating the observed trans-effect.