Does the scorpion venom peptide BmKn2 induce apoptosis in cancerous but not in normal human oral cells?
This study has suggested for the first time that BmKn-2 exerts selective cytotoxic effects on human oral cancer cells by inducting apoptosis via a p53-dependent intrinsic apoptotic pathway. BmKn-2 peptide originally derived from a natural source shows great promise as a candidate treatment for oral cancer, with minimal effects on healthy tissue.
COX-1 is the dominant isoform regulating the normal thickness of the protective surface pH gradient in mouse stomach.