Is growth rate of human preimplantation embryos sex dependent after ICSI but not after IVF?
A clear sex-related growth difference was found in human blastocysts originating from ICSI, but not in blastocysts originating from IVF. It is as yet unknown which mechanism is responsible for our findings. We hypothesize that the ICSI procedure might interfere with the process of imprinted X-inactivation.
Our findings suggest that growth hormone therapy alone can result in normal phallic size in patients with micropenis secondary to isolated congenital growth hormone deficiency.