Does glycoprotein 130 Inhibitor ameliorate Monocrotaline-Induced Pulmonary Hypertension in Rats?
Gp130 inhibitor upregulated BMPR2 expression in MCT-exposed lungs, restored the BMPR2/IL-6 balance, reduced IL-6-associated inflammation, inhibited pulmonary artery smooth muscle cell proliferation, and ameliorated pulmonary vascular remodelling in MCT-induced PH in rats.
These results demonstrate that AKAP12 may play an important role in tumor growth suppression and the survival of human colorectal cancer.