Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?
No conclusive evidence showing that 472G/A polymorphism is a reliable marker for panic disorder was found; moreover, large heterogeneity between studies existed. Large and more rigorous association studies investigating also the interaction with other genetic/environmental factors might provide more conclusive evidence.
In cirrhotic rats, atorvastatin inhibits hepatic RhoA/Rho-kinase signaling and activates the NO/PKG-pathway. This lowers intrahepatic resistance, resulting in decreased portal pressure. Statins might represent a therapeutic option for portal hypertension in cirrhosis.