Is improvement in left ventricular function in response to carvedilol accompanied by attenuation of neurohumoral activation in patients with dilated cardiomyopathy?
The improvement in EF with carvedilol therapy was proved to be accompanied by an improvement in neurohumoral factors.
NF-κB canonical pathway was activated in PA-mediated βTC3 cell apoptosis, whereas non-canonical pathway was inhibited. Reduced PGC-1α expression by PA in βTC3 cells could involve the activation of canonical NF-κB pathway, so as to deteriorate the PA induced apoptosis.