Is t cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism?
These findings demonstrate that induction of mixed chimerism with a nonmyeloablative regimen can prevent vascularized xenograft rejection by cellular and anti-Gal Ab-dependent pathways in GalT+/+-to-GalT-/- species combinations.
Maternal PS activity decreased as normal pregnancies progressed but decreased over time in cases with FGR. Excessive decreases in PS activity during pregnancy could contribute to development of FGR.