Does overexpression of a constitutively active protein kinase G mutant reduce neointima formation and in-stent restenosis?
Expression of a constitutively active PKG reduces neointima formation after balloon injury in rats and reduces coronary in-stent restenosis in pigs. PKGcat gene transfer may be a promising strategy for vasculoproliferative disorders.
A novel method of deriving local activation time is described, and delayed local activation time may explain failure of ATP in terminating VT in some patients.