Does elevated osteonectin/SPARC expression in primary prostate cancer predict metastatic progression?
In summary, we propose that evaluation of SPARC in primary CaP has potential as a prognostic marker of metastatic progression.
Lack of transgene expression by the prostate can be explained on the basis of the apparent species specificity previously observed for PSA. Expression in salivary gland is best attributed to identity between the nucleotide sequences of the PSA promoter and of a mouse glandular kallikrein normally secreted by the salivary gland.