Does changes in blood coagulability as it traverse the ischemic limb?
Passage of blood down an atherosclerotic artery leads to an increase in coagulability proportional to the degree of stenosis in that vessel. Passage of blood through ischemic tissue may also contribute to increased coagulability in peripheral arterial occlusive disease.
A single oral dose of Madopar co-administered with talipexole does not significantly change talipexole's pharmacokinetics in human.