Are higher arterial stiffness , greater peripheral vascular resistance and lower blood flow in lower-leg arteries associated with long-term hyperglycaemia in type 2 diabetic patients with normal ankle-brachial index?
Long-term hyperglycaemia is a major cause of impaired peripheral circulation in lower-leg arteries in diabetic patients without peripheral artery occlusive disease.
Our data suggest that loss of PTPRR in clinical PCa is one factor that might contribute to activation of the RAS/ERK1/2 pathway.