Does intracardiac injection of a capsid-modified Ad5/35 result in decreased heart toxicity when compared to standard Ad5?
Ultrasound-guided intramyocardial injection is an effective and safe way to deliver vectors to the heart. The observed severe tissue damage of Ad5-lacZ greatly undermines the efficient transgene expression and suggests that Ad5/35 capsid modification can result in safer adenoviral vectors for cardiovascular gene therapy, although at the cost of some vector transduction efficacy.
The presented findings suggest that long-term tea intake is associated with reduced levels of fasting blood glucose and lower prevalence of diabetes, in a cohort of elderly people living in Mediterranean islands.