Does eR stress response play an important role in aggregation of α-synuclein?
Our results indicate that an increase of wild-type α-synuclein can elicit ER stress response and sensitize cells to further insults. Most importantly, an increase of ER stress response can promote the aggregation of wild type α-synuclein.
Rapamycin protected livers from IRI by both autophagy and mTORC2-Akt activation mechanisms.