Is preoperative prostate specific antigen doubling time a useful predictor of biochemical progression after radical prostatectomy?
In our series of men with newly diagnosed, clinically localized prostate cancer shorter preoperative prostate specific antigen doubling time was associated with nonorgan confined disease but not with biochemical progression after radical prostatectomy. All calculations of prostate specific antigen kinetics may not be equivalent. Caution should be exercised when using prostate specific antigen doubling time in the pretreatment setting.
These observations suggest that humoral autoimmune reactions against recoverin and hsc 70 might be involved in the pathogenesis of CAR.