Does stem cell transplantation reveal that absence of macrophage CD36 is protective against atherosclerosis?
Protection in this model is primarily caused by loss of CD36 macrophage function.
The data suggest that butyrate oxidation deficiency in intestinal inflammation is a consequence of reduction in MCT1-mediated butyrate uptake. This reinforces the proposition that butyrate oxidation deficiency in IBD is not a primary defect.