Are induction of 11beta-hydroxysteroid dehydrogenase type 2 and hyperaldosteronism essential for enhanced sodium absorption after total colectomy in rats?
Induction of 11beta-HSD 2 is essential for enhanced mineralocorticoid action in the remnant ileum after total colectomy in rats.
This is the first known study to identify the association between SNPs in the UGT1A-3'-UTR and atazanavir-induced nephrolithiasis. Further studies are warranted to confirm this association and to elucidate how these SNPs might influence atazanavir exposure.