Does comparative genomic analysis of the DUF71/COG2102 family predict roles in diphthamide biosynthesis and B12 salvage?
This detailed analysis of the DUF71 family members provides an example of the power of integrated data-miming for solving important "missing genes" or "missing function" cases and illustrates the danger of functional annotation of protein families by homology alone.
These findings suggest that child-dependent ALEs are potentially an important outcome after youth with ADHD have an episode of MDD. Youth with ADHD who develop comorbid MDD should be closely monitored and offered interventions to address the potential burden of child-dependent ALEs lingering after a depressive episode.