Is proximal tibia the major problem in varus gonarthrosis?
Distal femoral joint showing less valgus significantly contributes to the deformity in varus gonarthrosis, also a very important contributor to the deformity. Abnormal forces applied to ankle may cause collapse in distal lateral tibial metaphysis and decrease LDTA in varus knees. Medial neck shaft angle may decrease due to possible abnormal loading angles to the femoral neck in some individuals with varus gonarthrosis.
Resveratrol inhibits key steps of the mevalonate pathway by mechanisms that are partly complementary to and partly comparable with simvastatin via reducing both expression and activity of HMGCR. A combination of resveratrol and simvastatin may be of potential clinical relevance to development new treatments of human endometriosis.