Are urinary N-acetyl-β-D-glucosaminidase levels positively correlated with 2-hr plasma glucose levels during oral glucose tolerance testing in prediabetes?
These results suggest that postprandial hyperglycemia is an independent factor that causes renal tubular damage in prediabetes patients.
In the genetically obese Zucker rat, the myocardial signal transduction cascade PKC-MAPK-ANP mRNA seems to be markedly impaired. It can be speculated that this abnormal cardiac cell signaling in obese rats reflects an early phase in the cardiac pathogenesis accompanying obesity.