Does vitamin C improve endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus?
Vitamin C selectively restores the impaired endothelium-dependent vasodilation in the forearm resistance vessels of patients with insulin-dependent diabetes mellitus. These findings indicate that nitric oxide degradation by oxygen-derived free radicals contributes to abnormal vascular reactivity in humans with insulin-dependent diabetes mellitus.
These data may explain perioperative pulmonary vasoconstriction in pediatric patients.