Does apolipoprotein E4 genotype increase the risk of postoperative cognitive dysfunction in patients undergoing coronary artery bypass graft surgery?
This study suggests an association between ApoE4 and early POCD, but further studies are needed to clarify a causative association. Such new studies should include a more homogenous patient sample and a longer follow-up.
These data suggest a defective DC function in patients with operable breast cancer. Switched-off DCs in patients with early breast cancer and decreased IL-12 production may be important factors for progressive tumour growth.