Are genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas globally coordinated but not locally targeted?
This work, using a novel and robust statistical approach demonstrates that, although a "second hit" mechanism is not likely the predominant mode of action for epigenetic dysregulation in cancer, the patterns of methylation events are associated with the patterns of allele loss. Our work further highlights the utility of integrative genomics approaches in exploring the driving somatic alterations in solid tumors.
The results clearly showed that TRO19622 promoted myelin formation with consequent functional improvement.