Does dietary fish oil attenuate cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency?
Dietary FO may attenuate cardiac hypertrophy with improvements in cardiac function and survival in JVS mice via modification of the molecular species composition of myocardial DAG and the consequent inhibition of PKC redistribution. These results suggest the implication of the molecular species composition of DAG in the pathogenesis of lipotoxic cardiomyopathy due to perturbations of fatty acid beta-oxidation.
Cumulative net negative balance quantity of fluid in survivors was much more than that in non-survivors. SOFA score and net balance quantity of fluid at Day 7 were the independent prognostic risk factors for septic shock. Cumulative net fluid balance at Day 7 was most negatively correlated with survival days. No significant inter-group difference existed in organ function at Day 7.