Is endoplasmic reticulum stress-induced JNK activation a critical event leading to mitochondria-mediated cell death caused by β-lapachone treatment?
Our results indicate that β-lap triggers induction of endoplasmic reticulum (ER) stress, thereby leading to JNK activation and mitochondria-mediated apoptosis. The signaling pathways that we revealed in this study may significantly contribute to an improvement of NQO1-directed tumor therapies.
At this date, methicillin remains in our institution a relevant marker of multiresistance but trend is changing.