Are leptin receptor somatic mutations frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma?
Based on analysis of liver tissue samples from patients, somatic mutations accumulate in LEPR in cirrhotic liver with chronic HCV infection. These mutations could disrupt LEPR signaling and increase susceptibility to hepatocarcinogenesis.
Data suggest that in patients with schizophrenia, functioning at least in part depends on the interaction between disorganization and OCS.