Does transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveal lasting epithelial cell alterations?
Analysis of the gene signature associated with remission allowed us to unravel pathways permanently deregulated in UC despite histological recovery. Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth.
Primary care physicians prefer computed-generated discharge summaries to dictated discharge summaries.