Is induction of IL-6 and IL-8 by house dust mite allergen Der p1 in cultured human nasal epithelial cells associated with PAR/PI3K/NFkappaB signaling?
These findings demonstrate that the PAR/PI3K/NFκB signaling pathway is involved in the induction of IL-6 and IL-8 in Der-p1-stimulated NECs from AR patients, and may have potential implications for the prevention and treatment of AR and asthma.
The model examined shows utility in predicting alcohol-treatment seeking in this sample. Age-related factors may deter treatment seeking by older male medical inpatients.