Does the HIV Tat protein affect processing of ribosomal RNA precursor?
Our data contribute to understanding the function of Tat in the nucleolus, where ribosomal RNA synthesis and cell cycle control take place. The impairment of nucleolar pre-rRNA maturation through the interaction of Tat with fibrillarin-U3snoRNA complex suggests a process by which the virus modulates host response, thus contributing to apoptosis and protein shut-off in HIV-uninfected cells.
The cause of pulmonary hypertension in neonates does influence the survival. Primary pulmonary hypertension in neonates was noted to be associated with poor outcome as compared to secondary pulmonary hypertension.