Does coagulation factor Xa synergistically interact with serotonin in inducing vascular smooth muscle cell proliferation?
Coagulation factor Xa and serotonin are mitogenic to VSMCs and also function as amplification factors to each other, suggesting that inhibition of neointimal proliferation after vascular injury may require the combined use of multiple growth factor inhibitors to simultaneously block several critical cellular activation pathways.
These findings suggest that altered central processing of pain is particularly characteristic of individuals with moderate to severe symptomatic knee OA.