Does combined use of SSRIs and NSAIDs increase the risk of gastrointestinal adverse effects?
SSRIs increase the risk of gastrointestinal adverse effects in first time users as compared with nonselective antidepressants. The combined use of SSRIs and NSAIDs strongly increases the risk of gastrointestinal adverse effects and should be avoided. The combination of nonselective antidepressants and NSAIDs does not have this effect.
Delaying a quit attempt prospectively predicts less success among smokers actively trying to quit. Whether this represents a causal effect is unclear. Further replication tests of our findings and, possibly, randomized trials of quitting sooner versus later are indicated. If delaying reduces cessation success, then treatments for smoking cessation should encourage quitting very soon upon treatment entry.