Is chronic cerebrospinal venous insufficiency associated with cognitive impairment in multiple sclerosis?
We find no evidence of an association between the presence and severity of CCSVI with cognitive impairment and depression in patients with MS.
Naloxone significantly reduces the progress of retinal lesions in DKO mice. Naloxone modulates microglia accumulation and activation at the site of retinal degeneration, which may be mediated by inhibition of the proinflammatory molecules of NO, TNF-α, and IL-β. The potential therapeutic effects of naloxone on retinal degeneration, including AMD, warrants further investigation.