Is the combined treatment of 1,25-dihydroxyvitamin D3 and a non-steroid anti-inflammatory drug highly effective in suppressing prostate cancer cell line ( LNCaP ) growth?
Although both 1,25(OH)2D3 and ibuprofen demonstrate in vitro anti-carcinogenic activities as a single drug treatment, the present results showed that the combined use of 1,25(OH)2D3 with ibuprofen is superior to treatment with a single drug.
These data are suggestive of a modest protective effect of estrogen exposure on the lenses of women. Further evaluation of this may be possible in studies currently under way in which postmenopausal estrogens are being tested for other (protective) effects.