Does dobutamine modulate lipopolysaccharide-induced macrophage inflammatory protein-1alpha and interleukin-8 production in human monocytes?
Macrophage inflammatory protein (MIP)-1alpha and interleukin (IL)-8 are reported to play an important role in early inflammatory stages, wound healing, sepsis, and some cardiovascular diseases. Our study suggests that dobutamine may inhibit macrophage chemotaxis, as well as lipopolysaccharide-induced MIP-1alpha and IL-8 production by human monocytes.
Use of NIRF imaging was associated with improved short-term renal functional outcomes when compared with RPN without selective arterial clamping and NIRF imaging. With this effect attenuated at later follow-up, randomized prospective studies and long-term assessment of kidney-specific functional outcomes are needed to further assess the benefits of this technology.