Does down-regulation of microRNA-184 contribute to the development of cyanotic congenital heart diseases?
Our findings indicate that inhibition of microRNA-184 may contribute to the development of cyanotic CHD via decreasing proliferation and inducing apoptosis of cardiomyocytes. Moreover, miR-184 inhibition may promote hypoxia-induced apoptosis via activation of caspase-3 and caspase-9. Congenital down-regulation of miR-184 may be a mechanism leading to CHD development.
Rates of intensification at a single clinic visit were quite low in all groups and were lowest in older patients with comorbidity.