Are single nucleotide polymorphisms in the P2X7 gene associated to fracture risk and to effect of estrogen treatment?
The P2X7 Glu496Ala and the Ile568Asn single nucleotide polymorphisms are associated with 10-year fracture risk in postmenopausal women and response to hormone replacement therapy treatment. Further, the Glu496Ala polymorphism is strongly influencing osteoclast apoptosis in vitro, which could contribute to increased fracture risk.
Intraoperative use of triamcinolone during PPV is not a high risk factor for acute endophthalmitis.