Does roux-en-Y gastric bypass decrease pro-inflammatory and thrombotic biomarkers in individuals with extreme obesity?
We observed that individuals with obesity that have hyperleptinemia have higher circulating PAI-1 levels, which could indicate increased risk for cardiovascular disease. The biomarkers of inflammation and thrombosis measured in this study decreased after RYGB, suggesting that the surgery may be effective in reducing pro-inflammatory and thrombotic risk in individuals with extreme obesity.
The findings of this study demonstrate a universal acceleration in the metabolic rates of both intermediary glucose metabolism and protein/amino acid catabolism during sepsis. Except for alanine, however, there appears to be no coupling between these two physiologic responses to sepsis.