Sentinel lymph node biopsy in contralateral prophylactic mastectomy: are we overtreating?
SLNB was performed in 37 (21.8%) of patients who underwent CPM in a community hospital. Only 3 (1.76%) of 170 patients who underwent CPM had findings on final pathology that would have justified axillary staging. This correlates with other published data regarding SLNB in CPM. Because SLNB is associated with significant morbidity, guidelines for SLNB in prophylactic mastectomy need to be established so to avoid overtreatment.
Our results suggest that expression of MIF may contribute to the progression and enhanced angiogenesis in a substantial portion of GCs.