Does cataract-causing αAG98R-crystallin mutant dissociate into monomers having chaperone activity?
The present study shows that the G98R mutation in αA-crystallin produces unstable oligomers that dissociate into active chaperone subunits. The chaperone activity of the dissociated subunits against four client proteins suggests that the αA-crystallin subunits are the minimal units of chaperone activity.
These results indicate that partial upper airway obstruction in women should be clinically recognized like obstructive sleep apnea.