Is production of interferon-gamma by tumor-sensitized T cells essential for interleukin-12-induced complete tumor eradication?
Production of IFN-gamma by IL-12-responsive tumor-sensitized T cells is both necessary and sufficient for complete tumor eradication induced by IL-12. T cells are the source, but not the target, of IFN-gamma during tumor regression.
Patients with herpes zoster are associated with an increased hazard of developing pyogenic liver abscesses.