Does inhibition of the CXCR3-mediated pathway suppress ultraviolet B-induced pigmentation and erythema in skin?
UVB irradiation activates CXCR3-mediated signalling that leads to melanin synthesis. PSA pretreatment shows a lightening effect partly by attenuating CXCR3-mediated signalling at the transcriptional level.
In an endemic situation with severe under-reporting, the obligatory notification of pertussis is not effective to prevent infection of insufficiently vaccinated children. Alternative vaccination strategies directed at the prevention of the spread of pertussis among insufficiently vaccinated children would probably be more effective and merit further investigation.