Does inhalation therapy with the synthetic TIP-like peptide AP318 attenuate pulmonary inflammation in a porcine sepsis model?
In summary, AP318 significantly attenuated intrapulmonary inflammatory response even without the presence or resolution of severe pulmonary edema in a porcine model of systemic sepsis-associated lung injury. These findings suggest an anti-inflammatory mechanism of the lectin-like domain beyond mere edema reabsorption in endotoxemic lung injury in vivo.
Inflammatory mediators play a role in acute ischaemic brain damage independently of hyperthermia.