Is treatment response in Kawasaki disease associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G?
Our data indicate sialylation levels of therapeutic IVIG are unrelated to treatment response in KD. Rather, lower sialylation of endogenous IgG and lower blood levels of ST6GALI mRNA and ST6Gal-I enzyme predict therapy resistance. These differences were stable over time, suggesting a genetic basis. Because IVIG-resistance increases risk of coronary artery aneurysms, our findings have important implications for the identification and treatment of such individuals.
There is a substantial positive association between PA and HRQoL, which is consistent over time for CRC survivors >2 years since diagnosis.