Are parkinson disease ( PARK ) genes somatically mutated in cutaneous melanoma?
The overrepresentation of somatic PARK mutations in CM suggests shared dysregulated pathways for CM and PD.
The pN models demonstrated superior prognostic value in comparison with the LNR and AJCC N staging. Future modifications of the nodal staging system should be based on the pN with a separate system for oropharyngeal cancers. Future trials should consider examining adjuvant treatment escalation in patients with >5 lymph nodes. Cancer 2016;122:1388-1397. © 2016 American Cancer Society.