Is flurbiprofen concentration in soft tissues higher after topical application than after oral administration?
Topical application is an effective method to deliver flurbiprofen to the human body, particularly to soft tissues near the body surface.
Early induction of JNK and Foxo1 activation plays an important role in fatty acid-induced apoptosis. Expressing a dominant-negative allele of Foxo1 reduces expression of apoptotic and ER stress markers and promotes beta-cell survival from fatty acid and ER stress, identifying a potential therapeutic target for preserving beta-cells in type 2 diabetes.