Is cleft palate caused by CNS dysfunction in Gad1 and Viaat knockout mice?
Our results are consistent with a role for Gad1 and Viaat in the central nervous system for normal development of the palate. We suggest that the alterations in GABA signaling lead to non-neural defects such as cleft palate as a secondary effect due to alterations in or elimination of fetal movements.
Interrater reliability was moderate to high for interpretation of the presence of sensory integrative dysfunction using SIPT scores. Less agreement was apparent regarding specific patterns of dysfunction. Results suggest that additional clinical information, such as clinical observations and case history, may be needed to make reliable distinctions among dysfunctional patterns.