Is there an independent association between waist-to-hip ratio and cardiovascular risk factors in overweight and obese women?
The results showed that in overweight and obese women, chances of having cardiovascular risk factors increased with WHR>or = 0.78 for premenopausal and with WHR>or = 0.84 for postmenopausal women.
Regulatory inhibition of GSK-3beta by Akt-1 in hypertrophied hearts is impaired, leading to activation during ischemia. Inhibition of GSK-3beta by Li or IMI improves tolerance to ischemia/reperfusion injury in hypertrophied myocardium. The likely protective mechanism is an increase in insulin-mediated glucose uptake, resulting in greater substrate availability for glycolysis during ischemia and early reperfusion.