Is use of a medium buffered with N-hydroxyethylpiperazine-N-ethanesulfonate ( HEPES ) in intracytoplasmic sperm injection procedures detrimental to the outcome of in vitro fertilization?
Our study showed that the use of media buffered with HEPES, during the microinjection of sperm into the oocytes, is detrimental for IVF outcome and should be avoided.
The reduced PIPRblue-red indicates a characteristic impairment of the melanopsin-driven pathway of ipRGCs in glaucoma patients, whereas the reduced MRA and increased SORRS suggest a disturbed synaptic function and altered interaction between outer photoreceptors, RGCs, and ipRGCs.