Does imipramine restore the long-term impairment of appetitive behavior in socially stressed rats?
Chronic imipramine administration restores the anhedonialike absence of anticipatory behavior in socially stressed rats. Predictive validity of the social stress model of human depression is suggested by the similar action of imipramine on the modeled behavior and on the anhedonia symptoms in depressive human patients.
MTX treatment is safe and beneficial as a steroid-sparing agent in PV.