Does rat strain minimally influence anesthetic and convulsant requirements of inhaled compounds in rats?
Rat strain has a minimal effect on the potency of inhaled anesthetics or the convulsant activity of inhaled compounds. It seems that the sites acted on by inhaled compounds to produce anesthesia and convulsions are conserved across common rat strains.
These data suggest that FVII overexpression is an alternative strategy for the treatment of hemophilia A with inhibitors.