Does sphingosine 1-phosphate enhance the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3?
These results demonstrate that the enhanced excitability produced by S1P is mediated by activation of S1PR1 and/or S1PR3.
AR overexpression is an effective way of hormone refractory prostate cancer cells to overcome the growth inhibitory effects of elevated serum TGFbeta1 levels even in the absence of DHT. These findings provide an explanation for how AR overexpression favors growth in HRPC.