Is tumor volume in insignificant prostate cancer : Increasing the threshold a safe approach to reduce over-treatment?
Our results have shown that, with a median follow-up of 84 (IQR 70-102) months, patients in our cohort with localized Gleason 6 PCa with a total TV 0.5-2.5 cm(3) have a BCR rate of 0%. We would support a more liberal total TV threshold of 2.5 cm(3) for the further development of algorithms to identify patients suitable for active surveillance.
We present a thorough summary that could serve as a common standard and as a basis for comparison of future trials.