Does mycobacterium leprae alter classical activation of human monocytes in vitro?
Exposure to M. leprae has an inhibitory effect on M1 macrophage polarization, likely mediated through PGL-1. By directing monocyte/macrophages preferentially towards M1 activation, BCG vaccination may render the cells more refractory to the inhibitory effects of subsequent M. leprae infection.
All above the compounds were isolated from the plant for the first time and the compound 1 is a new compound.