Does the dipeptide Arg-Gln inhibit retinal neovascularization in the mouse model of oxygen-induced retinopathy?
Arg-Gln dramatically inhibited retinal neovascularization in the OIR model. This effect was associated with a reduction in retinal VEGF mRNA levels. Similarly the dipeptide reduced VEGF expression in hRPE cells, a cell type likely to respond to retinal hypoxia by expressing VEGF. Arg-Gln appears to be safe and, with future studies in human infants, may prove beneficial in the prevention of ROP.
Pretreatment ADC values may be an independent predictor of bladder cancer recurrence.