Does systemic Escherichia coli infection influence clinical symptoms and neurodegeneration in experimental autoimmune encephalomyelitis?
We could not confirm the detrimental effect of lipopolysaccharide-induced systemic inflammation, a model frequently used to mimic the bacterial infection, previously observed in animal models of MS. Our results indicate that the effect of an acute E. coli infection on the course of MS is less pronounced than suspected and underline the need for adequate models to test the role of systemic infections in the pathogenesis of MS.
A systems approach identified a novel genetic contribution to human HF and a promising therapeutic agent efficacious in an HF model.