Does short-Term Caloric Restriction suppress Cardiac Oxidative Stress and Hypertrophy Caused by Chronic Pressure Overload?
Chronic pressure overload increased cardiac oxidative damage, in association with cardiac hypertrophy and fibrosis. Short-term CR suppressed oxidative stress and improved cardiac function, suggesting that short-term CR could be a useful strategy to prevent pressure overload-induced cardiac injury.
Our results indicate that a dysfunction of the cytokine network associates with aging and point to a specific role of IL-1alpha in endothelial senescence.