Is deficient carbonic anhydrase 9 expression in UPR-impaired cells associated with reduced survival in an acidic microenvironment?
Our data indicate that UPR-impaired U373 cell lines have a defect in pH regulation due to reduced CA9 expression that sensitizes to acidic conditions. We speculate that this defect may contribute to the poor growth of UPR-defective tumors.
These data suggest that completion of follow-up questionnaires in either informed or blind format will have little impact on HHI responses, most likely because of the many other factors that combined to influence hearing aid outcome.