Does linear extrapolation of missing radiographic change scores in clinical trials spuriously overestimate group radiographic changes in rheumatoid arthritis?
LE led to stable estimates of progression at the group level, but increasing variability with increasing proportions of missingness. In contrast, LOCF imputation systemically underestimated mean progression with increasing proportions of missingness, with artificially reduced variability estimates.
Normalization of peak exercise oxygen consumption for predicted values adds only minimal prognostic information. A peak exercise oxygen consumption<14 ml/kg/min remains a reasonable guideline by which to time heart transplantation.