Does azithromycin reverse airflow obstruction in established bronchiolitis obliterans syndrome?
This case series confirms the benefit of azithromycin in not only halting, but reversing the declining lung function seen in patients with BOS. This benefit appears to be maintained over time. Low-dose macrolides offer a new and exciting therapeutic strategy for the treatment of progressive BOS, and further clinical and translational mechanistic studies are required.
These findings suggest that locally produced IL-5 plays an important role in eosinophil accumulation of AEP.