Do circulating plasma factors induce tubular and glomerular alterations in septic burns patients?
Plasma from burns patients with sepsis-associated ARF contains factors that affect the function and survival of tubular cells and podocytes. These factors are likely to be involved in the pathogenesis of acute tubular injury and proteinuria, which is a negative prognostic factor and an index of renal involvement in the systemic inflammatory reaction.
These studies demonstrate that factors from both the immune and endocrine systems can interact to control HLA-DR expression in the ovary.