Does dual ACE-inhibition and AT1 receptor antagonism improve ventricular lusitropy without affecting cardiac fibrosis in the congenic mRen2.Lewis rat?
We conclude that the lusitropic benefit of early dual RAS blockade may be due to improved vascular hemodynamics and/or cardiac calcium handling rather than effects on extracellular matrix reduction.
Our findings implicate MAPK activation as an early event in melanoma progression, and MAPK may be a potential target for pharmacologic intervention.