Does down-regulation of osteopontin suppress growth and metastasis of hepatocellular carcinoma via induction of apoptosis?
Osteopontin may facilitate tumorigenesis and metastasis through prevention of tumor cells from apoptosis. RNA interference-mediated depletion of osteopontin may be a promising strategy for the treatment of HCC by sensitizing the chemotherapeutic drugs.
A single-center, retrospective study.