Performance profiling in primary care: does the choice of statistical model matter?
Differences among models were relatively small, but the choice of statistical model did affect the rankings. In addition, most measures appear to be driven largely by chance, regardless of the model that is used. Profilers should pay careful attention to the choice of both the statistical model and the performance measures.
Our observations support a cell autonomous role for TCF7L2 in pancreatic β-cells suggested by most, though not all, investigations. βTCFDN is a novel model for further exploring the role of TCF7L2 in β-cell genesis and metabolic homeostasis.