Does depo-provera treatment abrogate protection from intravenous SIV challenge in female macaques immunized with an attenuated AIDS virus?
Depo-Provera did not diminish the control of viral replication after intravenous SIV challenge in female macaques immunized with a live-attenuated lentivirus. This result contrasts with the previously reported effect of Depo-Provera(R) on protection from vaginal SIV challenge and strongly implies that the decreased protection from vaginal challenge is due to effects of progesterone on the genital tract rather than to systemic effects. Further, these results demonstrate that the effects of hormonal contraceptives on vaccine efficacy need to be considered in the context of testing and use of an AIDS vaccine.
Application of capsicum plasters on acupoints offers a valuable choice in the prevention of EA in children.