Does supra-physiological rhGH administration induce gender-related differences in the hypothalamus-pituitary-thyroid ( HPT ) axis in healthy individuals?
We suggest that rhGH inhibits TSH at central level both in males and females. The pattern of normalization was different in the two genders probably due to gonadal steroids modulation on GH-IGF-I axis.
It is concluded that up-regulation of tumor suppressor and growth regulatory genes may play an important role in the pathogenesis of severe early-onset preeclampsia.