Does the matrix metalloproteinase inhibitor RS-130830 attenuate brain injury in experimental pneumococcal meningitis?
This study identifies MMP inhibition, specifically with RS-130830, as an efficient strategy to attenuate disease severity and cortical brain injury in PM.
Chemokines, in particular CCL2, are associated with survival in IPD and correlate with pneumococcal bacterial loads, disease presentation, and outcome.