Does immunostimulatory oligodeoxynucleotide induce TH1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice?
The data demonstrate that the coadministration of cedar pollen allergens and ISS-ODNs before secondary T(H2) and IgE responses or during ongoing primary T(H2) and IgE responses brings about a T(H1)-shifted immune response and inhibition of IgE antibody production, suggesting that this coadministration strategy may provide a novel type of immunotherapy for cedar pollinosis.
C-Raf siRNA knock-down results in decreased viability of YULAC (B-Raf(V600K)) and YUROB (B-Raf(WT)) melanoma cells, likely mediated by Bcl-2 inhibition rather than mitogen-activated protein kinase inhibition. Cotargeting C-Raf and parallel pathways might be an effective therapeutic approach for melanoma. C-Raf expression is up-regulated in a subset of melanomas but not in nevi, suggesting that it might be a valuable diagnostic marker and therapeutic target.