Do glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes?
These results support an important role of the presynaptic partner in the induction and differentiation of the postsynaptic structures.
4alphaPDD selectively activates TRPV4 in sensory neurons projecting from the colon, and TRPV4 activation causes visceral hypersensitivity. TRPV4 activation is implicated in the nociceptive response to CRD in basal conditions and in PAR(2) agonist-induced hypersensitivity. These results suggest a pivotal role for TRPV4 in visceral nociception and hypersensitivity.