Does alemtuzumab preconditioning allow steroid-calcineurin inhibitor-free regimen in live-donor kidney transplant?
This clinical trial provides a good insight into a potentially effective steroid and calcineurin inhibitor-free protocol with the use of alemtuzumab induction in combination with sirolimus.
A decrease in male fertility cannot be ruled out on the basis of these results, but if present, it is minor and totally outweighed by other favorable developments. As the main explanation for our findings, we propose a decrease in the prevalence of secondary subfertility as a result of the eradication of gonorrhea.