Is resveratrol equipotent to perindopril in attenuating post-infarct cardiac remodeling and contractile dysfunction in rats?
Treatment with resveratrol or perindopril was equivalent in significantly improving remodeling and attenuation of contractile dysfunction in MI rats. Combination treatment also attenuated the cardiac abnormalities. The improvement in cardiac abnormalities may partly be through reducing oxidative stress by preventing the decrease in the activity of superoxide dismutase and catalase, and decreasing cardiac inflammation and fibrosis.
We demonstrated the efficacy of a pilot community-based educational cardiovascular program in reducing cardiometabolic risk and inflammation in high-risk African American women. Our successful culturally appropriate and sustainable model could be implemented as part of comprehensive efforts to improve community-based health outcomes.