Prediction of microcephaly at birth using three reference ranges for fetal head circumference: can we improve prenatal diagnosis?
The evaluated reference ranges all result in considerable over-diagnosis of fetal microcephaly. The use of the two new HC reference ranges did not significantly improve micB prediction compared with that of Jeanty et al., whilst use of additional characteristics and stricter HC cut-offs could improve the PPV with an increase in false negatives. The postnatal OFC deviates significantly less from the mean compared with the prenatal HC, and we propose that adjustment for this would enable better prediction of the actual OFC deviation at birth. Copyright © 2015 ISUOG. Published by John Wiley&Sons Ltd.
Providing a collateral may have an impact on respondent's self-reported drinking. Alternate explanations for this finding are discussed.