Is heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines revealed by Aldefluor flow cytometry-based assay?
Aldefluor assay can be adapted successfully to measure ALDH activity in lung cancer cells and may have the advantage of providing real time changes in ALDH activity in viable cells treated with siRNA or chemotherapy.
From present observational studies, use of metformin appears to be associated with a reduced risk of pancreatic cancer in patients with T2DM. Further investigation is needed.