Does iKVAV regulate ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation?
Our results demonstrated that IKVAV stimulated BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways. This study is the first to reveal an enhancement effect of IKVAV peptide on BMMSC at the signal transduction level, and the outcome could provide experimental evidence for application of IKVAV-grafted scaffolds in the field of BMMSC-based tissue engineering.
Although practices have been willing to devote considerable time and effort to the project, the diversity of software has precluded a simple methodology for data collection and analysis. The amount of useful information retrieved so far, has been limited but a number of important lessons have been learned which have implications for similar information projects and the use of primary care information in service planning.