Does an aqueous extract of Poncirus fructus activate the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction?
It was found that PF-W exerts its prokinetic activity through a 5-HT4R-mediated pathway, with no interaction with hERG channels. Therefore, PF-W is a good candidate that might be developed as a prokinetic agent with fewer expected cardiac side effects.
Inspired gas humidity cannot be predicted reliably from humidifier temperature. Accurate control will require a new generation of humidifiers that measure inspired gas humidity.