Is a non-stop S-antigen gene mutation associated with late onset hereditary retinal degeneration in dogs?
Identification of this non-stop SAG mutation in dogs affected with retinal degeneration establishes this canine disease as orthologous to Oguchi disease and SAG-associated retinitis pigmentosa in humans, and offers opportunities for genetic therapeutic intervention.
There is a survival benefit with increasing BMI in patients overall. However, while these results persist in patients>65 years, in young people there are no changes in mortality. Patients with the highest inter-annual variability in weight have an increased risk.