Do acute lymphoblastic leukaemia cells express CCR7 but not higher amounts of IL-10 after CD40 ligation?
The results show that leukaemia-derived dendritic cells obtained with CD40 ligation express CCR7 - chemokine is involved in migration to lymph nodes and does not produce higher amounts of IL-10, a potent immunosuppressive cytokine. Our preclinical findings could be used in the design of immunotherapy trials for the treatment of children with ALL.
Low vitamin D levels are associated with disease activity in CD and increase after infliximab treatment.