Is rbAp48 a target of nuclear factor-kappaB activity in thyroid cancer?
Our results show that RbAp48 is a NF-kappaB-regulated gene playing an important role in thyroid cancer cell autonomous proliferation.
Biological availability of thyroid hormones in patients with toxic adenomas might be elevated in selected organs although serum levels of fT4, fT3 and TSH are normal. This might be due to an increased production rate of T4 on the one hand and a specific peripheral T4/T3 conversion rate on the other hand. This might lead to an organ-selective thyrotoxicosis in the periphery without concerning the thyrotroph, so that TSH stays within the normal range. Necessity of therapeutic interventions depends on clinical signs and symptoms.