Are resting blood pressure and bone mineral content inversely related in overweight and obese Hispanic women?
These results reveal that BMC is partially and inversely correlated with resting SBP and DBP in premenopausal Hispanic women; in addition hypertensive women have lower adjusted means of BMC than normotensive women. Sustained hypercalciuria and ensuing hyperparathyroidism as consequences of high BP may be the mechanisms that explain the pathophysiology of increased bone mineral loss in hypertension.
These findings exclude mutations that could be located deep in the introns and affecting either normal splicing or lead to mechanisms causing some unknown rearrangements of the FVIII gene. In fact, our results point to the presence of still unknown factor(s) causing HA, which might be either allelic or in the close proximity of the FVIII gene or non-allelic associated with other genetic loci that are involved in the processing of the FVIII protein.