Is wolcott-Rallison syndrome the most common genetic cause of permanent neonatal diabetes in consanguineous families?
WRS is the most common cause of permanent neonatal diabetes mellitus in consanguineous pedigrees. In addition to testing patients with a definite clinical diagnosis, EIF2AK3 should be tested in patients with isolated neonatal diabetes diagnosed after 3 wk of age from known consanguineous families, isolated populations, or countries in which inbreeding is frequent.
The present study provides the first evidence that exposure to Methylene blue during late gestation induces preterm delivery and fetal growth restriction. These findings seem to favour the idea that soluble guanylate cyclase and its catalytic product play a role in the control of myometrial contractility and fetal growth process.