Does dual antibiotic prophylaxis better prevent surgical site infections in total joint arthroplasty?
The addition of vancomycin as a prophylactic antibiotic agent apparently did not reduce the rate of SSI compared to cefazolin alone. Use of vancomycin in addition to cefazolin appeared to reduce the incidence of MRSA infections; however, the number needed to treat to prevent a single MRSA infection was very high.
Heteroresistance is an important factor for the inconsistency between the results of phenotype and genotype drug susceptibility tests. For improving the rapid detection of drug resistant tuberculosis, novel genotypic drug susceptibility test methods with higher sensitivity should be developed and applied.