Does pigment epithelium-derived factor associate with neuropathy and fibrosis in pancreatic cancer?
PEDF increases PSC activity, thereby contributing to the desmoplasia of pancreatic cancer. PSC overactivation likely leads to periacinar fibrosis and degeneration of fine acinar innervation. Increased focal PEDF expression in cancer cells correlates with neuropathic changes and better patient survival.
CDK10 is not a target for aberrant DNA methylation in breast cancer.