Is apo-AII an elevated biomarker of chronic non-human primate ethanol self-administration?
An open proteomic screen of serum and confirmation in a separate set of animals found Apo-AII to be increased in the serum of ethanol self-administering monkeys. These results are consistent with previous clinical studies of human ethanol consumption and serum apolipoprotein expression. Moreover, these results validate the use of non-human primates as a model organism for proteomic analysis of ethanol self-administration biomarkers.
Ad could protect against CIH-induced renal cell apoptosis through inhibiting ROS-related ER stress.