Is overexpression of the human homologue for Caenorhabditis elegans cul-4 gene associated with poor outcome in node-negative breast cancer?
Our data provide evidence for the first time that CUL-4 could play an important role in the development and progression of human cancer.
Synthetic PACAP ameliorates acute small intestinal inflammation and extra-intestinal sequelae by down-regulating Th1-type immunopathology, reducing oxidative stress and up-regulating anti-inflammatory cytokine responses. These findings provide novel potential treatment options of inflammatory bowel diseases.