Does antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 ( Everolimus ) increase radiosensitivity in solid cancer?
Endothelial cells seem to be most sensitive to combination of mTOR inhibition and radiotherapy. Additive tumor growth delay using the mTOR inhibitor RAD001 and radiotherapy in vivo therefore might rely on combined antiangiogenic and antivascular effects.
Pyeloplasty is the most effective and permanent treatment for PUJ obstruction. Newer endoscopic procedures currently used must be carefully assessed against this 'gold standard' before becoming widespread.