Are cardioprotective effects of ischaemic preconditioning mediated by prostanoids?
Preconditioning both with and without aspirin significantly reduced infarct size and the incidence of ventricular tachycardia and/or fibrillation. As the effects of preconditioning were not prevented by aspirin, this suggests that the cardioprotective effects of preconditioning are not mediated by prostanoids in the rat model.
RRP1B, a breast cancer metastasis suppressor, regulates gene expression through heterochromatinization and transcriptional repression, which helps our understanding of mechanisms that drive prognostic gene expression in human breast cancer.