Abstinence rates and predictors of outcome for smoking cessation: do Brazilian smokers need special strategies?
The higher percentage of smoking cessation was achieved using multiple therapies (counseling + NRT + bupropion). The only significant predictor of failure detected was severe nicotine dependence.
Oral administration of doxycycline significantly inhibited collagenase and gelatinase activity in human OA cartilage. The effective dose is likely to be well tolerated during chronic administration, e.g., in a clinical trial to assess the potential of the drug to modify cartilage breakdown in OA.