Do variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer?
Inherited mutations in UNC5C prevent apoptosis and increase risk of CRC.
FcgammaRIIa allotypes capable of initiating efficient cellular effector functions are associated with increased risk for GBS and a more severe disease course. FcgammaR alleles may constitute novel genetic risk markers for GBS.