Does tCTP increase stability of hypoxia-inducible factor 1α by interaction with and degradation of the tumour suppressor VHL?
These data have demonstrated that TCTP binds to the β domain of VHL through competition with HIF1α, which promotes VHL degradation by the ubiquitin-proteasome system and HIF1α stability.
The results demonstrated that nicorandil reduces minor cardiac marker elevation after coronary stenting.