Does sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration require Galpha12/13 protein-mediated phospholipase C activation?
S-1-P induces oxygen free radical generation through a Galpha12/13, PLC-beta-mediated mechanism that facilitates VSMC migration. To our knowledge, this is the first description of PLC-mediated oxygen free radical generation as a mediator of S-1-P VSMC migration and illustrates the need for the definition of cell signaling to allow targeted strategies in molecular therapeutics for restenosis.
In non-obese Japanese adults, LDL-C/HDL-C ratio may be the best reliable marker of insulin resistance.