Do mAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction?
This study demonstrates that ERK and p38 kinase cascades play important roles in wound contraction. Additionally, these data implicate hsp27 as being a key molecule in modulating the effects of these kinases.
CRT-induced LV reverse remodelling is reflected by changes in plasma OPN. Circulating OPN may represent a marker of LV dilation/impairment and an indicator of the response to HF therapies promoting LV reverse remodelling.