Does thrombopoietin contribute to enhanced platelet activation in cigarette smokers?
Elevated TPO contributes to enhance platelet activation and platelet-monocyte cross-talk in cigarette smokers.
During 12 months of treatment of RA patients with TNF-alpha blockers, bone formation seems increased while bone resorption seems decreased. The reduced rate of OP seems supported by the same mechanisms involved in the decreased bone joint resorption during anti-TNF-alpha therapy (i.e. increase of osteoblastic activity and decrease osteoclastic activity).