Does chungsimyeonja-eum inhibit inflammatory responses in RAW 264.7 macrophages and HaCaT keratinocytes?
Our results suggest a possible therapeutic application of CSYJE for treating inflammatory diseases.
Purine depletion causes slow cell death in cells that have passed the G1 checkpoint, but cytostasis in cells that are arrested at the G1 checkpoint. The GARFT inhibitor, at physiological folate concentrations, thus causes selective cytotoxicity to cells lacking a functional G1 checkpoint.