Does a functional polymorphism of the stromelysin gene ( MMP-3 ) influence susceptibility to primary sclerosing cholangitis?
Stromelysin polymorphism may influence susceptibility and disease progression in PSC.
Growth factor and catabolic cytokine concentrations were influenced by the cellular composition of PRP. Platelets increased anabolic signaling and, in contrast, leukocytes increased catabolic signaling molecules. Platelet-rich plasma products should be analyzed for content of platelets and leukocytes as both can influence the biologic effects of PRP.