Is interleukin-6 production upregulated by interaction between disc tissue and macrophages?
Our results demonstrated that interaction between disc tissue and macrophage is necessary for upregulation of IL-6 production. Immunohistochemical staining also indicated that infiltrated macrophages played a major role in production of IL-6, suggesting that infiltration of macrophages into herniated disc material may be a trigger for IL-6 production and associated neurologic symptoms.
Our findings suggest that TS fatigue affects EMG parameters, PT and pain in athletes and non-athletes similarly.