Is visfatin related to lipid dysregulation , endothelial dysfunction and atherosclerosis in patients with chronic kidney disease?
Overall, the study showed that in CKD patients, higher visfatin levels are associated with decreased GFR, increased serum triglyceride and LDL cholesterol levels and impaired endothelial function. Moreover, visfatin levels also correlated with hsCRP levels and carotid IMT, suggesting that visfatin may play an important role in uremia-related atherosclerosis.
In the C. elegans male, DM domain genes dmd-3 and mab-23 regulate expression of cell sub-type characteristics that are critical for mating success. In particular, these factors limit the number of DA neurons in the male nervous system by sex-specifically regulating a phylogenetically conserved dopamine biosynthesis gene transcription factor. Homologous interactions between vertebrate counterparts could regulate sex differences in neuron sub-type populations in the brain.