Does lineage tracing demonstrate no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis?
Hepatocytes and cholangiocytes do not undergo EMT in murine models of hepatic fibrosis.
These data suggest that intrathecal morphine is effective in reducing the visceromotor response to UCD and that the reduction in efficacy of systemic morphine in this model is unlikely to reflect a reduction of the efficacy of morphine at the spinal level. These data agree with clinical studies that indicate that systemic morphine, in doses that reduce acute postoperative pain, have minimal to no effect in women in labor, yet intrathecal injection of opioids provides rapid, complete analgesia.