Does computer analysis of mFISH chromosome aberration data uncover an excess of very complicated metaphases?
Standard models of DNA damage induction/repair/misrepair explain the main trends of the data as regards the fraction of metaphases having a particular number of colours involved in colour junctions. However, all standard models systematically under-predict the observed fraction of metaphases where a large number of different chromosomes participate in aberrations. An early appearance of chromosomal instability could explain most of the discrepancies.
Knowing former smokers was associated with increased likelihood of achieving smoking abstinence among homeless smokers.