Are serum TNF-α , B2M and sIL-2R levels biological correlates of outcome in adjuvant IFN-α2b treatment of patients with melanoma?
Low TNF-α levels are negatively associated with relapse-free survival. Conversely, high TNF-α levels are correlated with toxicity but seem to be beneficial to patients with regard to relapse-free survival. B2M and sIL-2R are biological markers of adjuvant IFN-α2b treatment.
We hypothesize that our patients had passed the top of the Frank-Starling curve and were on the descending limb at the initial examination. With UF, patients first shifted to the left and upward on the curve. With further UF, they came down the ascending limb of the curve. In conclusion, paradoxical blood pressure rise during UF is caused by increased cardiac output, mediated by volume overload and can be treated by intensified UF.