Do cyclooxygenase metabolites mediate glomerular monocyte chemoattractant protein-1 formation and monocyte recruitment in experimental glomerulonephritis?
Our studies demonstrate that COX products may serve as endogenous repressors of MCP-1 formation in experimental glomerulonephritis. The data suggest that COX-1 and COX-2 products mediate these effects differently because the selective COX-2 inhibitors had less influence on chemokine expression.
OSA is associated with higher CRP levels in patients with normal or impaired renal function, but cTnT is elevated in OSA patients with impaired renal function only. In this pilot study, both parameters suggest an important role of sleep related breathing disorders on cardiac stress and chronic inflammation.