Is substantia nigra an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures?
In the focal pilocarpine model, TPM does not exert its anticonvulsant effect at the site of seizure initiation. We identified the SNR as a site of action of TPM, and showed that the nigral GABA-ergic system is central to TPM's anticonvulsant effect in SNR. Anticonvulsant effects and neurochemical changes in hippocampus following intranigral TPM administration suggest the existence of a nigro-hippocampal circuit, which may be involved in the control of limbic seizures.
The accuracy of the software for space analysis evaluation on digital models is clinically acceptable and reproducible when compared with traditional plaster study model analyses.