Is hepatic lentiviral gene transfer associated with clonal selection , but not with tumor formation in serially transplanted rodents?
We did not find evidence for vector-induced tumors. LV hepatic gene therapy showed a favorable risk profile for stable and long-term therapeutic gene expression. Polyclonality of hepatocyte regeneration was maintained even in an environment of enforced proliferation.
Impregnation with antimicrobials presents a challenge to the physical and mechanical properties of a polymer. However, despite increased water uptake SBS remained acceptable for a temporary lining material and comparable to drug-free long-term lining materials. Moreover, the enhanced water uptake could contribute to improved leaching.