Does dominant negative suppression of major histocompatibility complex genes occur in trophoblasts?
These data indicate that dominant negative trophoblast factors, either directly or indirectly, suppress expression of the MHC genes. If these factors can be cloned, the potential exists for developing transgenic animals that cannot express MHC or peptide antigen to T cell receptors through the MHC system.
More frequent statin use is associated with accelerated CAC in T2DM patients with advanced atherosclerosis.