Is imipenem heteroresistance in nontypeable Haemophilus influenzae linked to a combination of altered PBP3 , slow drug influx and direct efflux regulation?
The present study provides robust evidence indicating that in combination with the altered PBP3, the slowed drug influx and its enhanced efflux due to the loss of regulation led to the development of imipenem heteroresistance in NTHi.
In three out of 25,057 pregnancies (0.01%), non-invasive prenatal testing and fetal ultrasound would have missed a chromosomal anomaly that would have been identified by NT measurement. © 2015 John Wiley&Sons, Ltd.