Slightly absurdly, the answer is "yes on the backend, no on the frontend". We've never figured out a good way to display information about which directory (or files) within a project an update setup is targeting, so while the backend supports have multiple update setups of the same language for the same project, there's no way to add them in the frontend. If you've got a particular repo in mind, let me know and I'll take a look at whether I can get things set up manually on our side.