In what year was mevastatin discovered? [SEP] Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use.
not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment