Little Sister
Little Sister may refer to:

Birth order

Literature
The Little Sister, a 1949 novel by Raymond Chandler
Kana: Little Sister, a 1999 Japanese visual novel

Film and television
The Little Sister (1911 film), a short
The Little Sister (1914 film), a short starring Tom Mix
Little Sister (1921 film), a 1921 Italian silent film
The Little Sister (1986 film), featuring Peter Gerety
Little Sister (1992 film), a comedy starring Jonathan Silverman and Alyssa Milano
Little Sister (1995 film), a Dutch film
Little Sister (2010 film), directed and written by Richard Bowen
Little Sister (2016 film), directed and written by Zach Clark
"The Little Sister" (Roseanne), a 1989 episode of the TV sitcom Roseanne
"Little Sister" (Golden Girls episode)

Music
Little Sister (band), Sly & the Family Stone's background vocalists
"Little Sister" (Elvis Presley song), a song released by Elvis Presley in 1961, and later covered by Ry Cooder and by Dwight Yoakam
"Little Sister" (Queens of the Stone Age song)
"Little Sister", a song by Jewel from Pieces of You
"Little Sister", a song by the Runaways from Waitin' for the Night
"Little Sister", a song by Lou Reed from the Get Crazy soundtrack
"Little Sister", a song by Nico from Chelsea Girl
"Little Sister", a song by Cheap Trick from Standing on the Edge
"Bonnie Jean (Little Sister)", by David Lynn Jones
"Little Sister", a song by Trixie Mattel from One Stone

Religion
Little Sisters of the Abandoned Elderly, founded in Spain, a Roman Catholic religious congregation
Little Sisters of the Assumption, a Roman Catholic religious institute
Little Sisters of Jesus, a Roman Catholic congregation
Little Sister Magdeleine of Jesus (1898–1989), founder of the Little Sisters of Jesus
Little Sisters of the Lamb, a branch of a Roman Catholic religious institute, shaped both by Dominican and by Franciscan spirituality
Little Sisters of the Poor, founded in France, a Roman Catholic religious institute for women
Little Sisters of the Sacred Heart, a religious congregation in Montpellier

Other uses
Little Sisters, an informal name for a group of some of the smaller members of the British Virgin Islands
Little Sister (BioShock), fictional young girls in BioShock and BioShock 2
Little Sister's Book and Art Emporium, a bookstore in Vancouver, Canada
Little Sisters Book and Art Emporium v Canada (Minister of Justice), a court case regarding freedom of speech involving the bookstore

See also

Nation's Little Sister, an informal title in the South Korean entertainment industry
"Baby Sister", a 1985 song by La Toya Jackson
LittleSis, an accountability project of the Public Accountability Initiative
All pages with titles beginning with Little Sister 
All pages with titles containing Little Sister
Lillasyster (Swedish for "little sister"), a Swedish rock band
Petite soeur (disambiguation) (French: little sister)