SOB
Sob is a verb meaning cry. 
Sob and SoB may refer to:

Souls on Board (sometimes POB for People on Board), used in Aviation communication
Seventeen or Bust, a distributed computing project
Special Operations Battalion (SOB), an elite unit of the Croatian army
Society of Old Brooklynites
Son of a bitch, an insult or curse phrase, sometimes abbreviated as "S.O.B."
Sons of Ben (MLS supporters association)
Suggested opening bid, a term in auctioneering
Super Oralloy Bomb, a nuclear bomb
Senate Office Building
Dirksen Senate Office Building
Russell Senate Office Building
Hart Senate Office Building
S.O.B. Hill, a mountain in Utah, United States
Start of business, the start of the business day (as opposed to EOB)

Biomedicine
Shortness of breath or dyspnea, a medical symptom relating to breathing difficulties
Sobralia, a genus of orchids
Super optimal broth, a bacterial growth medium

Music and media
S.O.B. (film), a 1981 film by Blake Edwards
The Sob, a 1953 Turkish film
S.O.B. (band), a Japanese grindcore band
"S.O.B." (song), by Nathaniel Rateliff and the Night Sweats, 2015
Scars on Broadway, an American rock band
Sons of Batman, a group of characters in a Batman comics miniseries
Sons of Butcher (band), a Canadian rock band
Sons of Butcher (TV show), a cartoon inspired by the band
Sounds of Blackness, an American vocal and instrumental ensemble
SOB's, Sounds of Brazil, a live music venue in New York City
Styles of Beyond, an underground rap group
Switched-On Bach, an album by Walter Carlos
S.O.B.s, an episode of the television series Arrested Development

Transport
Seaford-Oyster Bay Expressway
Balaton Airport, SOB in IATA code
South Bend station (Amtrak), SOB is its station code
Southbourne railway station, SOB in Network Rail code
Stadt-Omnibus Bern, a former public transport operator in Bern, Switzerland
Südostbahn, a railway company in Switzerland
SüdostBayernBahn, a railway company in southern Germany
MS Spirit of Britain, a Dover - Calais P&O Ferry

Toponyms
Sob (river), a river in Siberia, a tributary of the Ob
Sob River, a river in Ukraine, a tributary of Southern Bug