Substance
Substance may refer to:

Matter, anything that has mass and takes up space

Chemistry
Chemical substance, a material with a definite chemical composition
Drug substance
Substance abuse, drug-related healthcare and social policy diagnosis or label
Substance dependence, drug-related healthcare and social policy diagnosis or label

Arts, entertainment, and media
Music
Substance (Blank & Jones album), 2002
Substance (Joy Division album), 1988
Substance 1987, a New Order album
"Substance", a song by Haste the Day on the album That They May Know You
"Substance" (song), a 2022 song by Demi Lovato

Other media
SubStance, an interdisciplinary journal on literature published by the University of Wisconsin Press
Metal Gear Solid 2: Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty

Religion and philosophy
Dravya, a term used in Jainism to refer a substance
Ousia, term for substance in ancient Greek philosophy and Christian theology
Substance theory, an ontological theory positing that a substance is distinct from its properties

See also
Substance control (disambiguation)
Substantial (rapper)