Chris O'Brien
Chris O'Brien may refer to:

Chris O'Brien (American football) (1881–1951), owner of the Chicago Cardinals and co-founder of the National Football League
Chris O'Brien (baseball) (born 1989), minor league baseball player
Chris O'Brien (rugby) (born 1950), Welsh rugby league player
Chris O'Brien (surgeon) (1952–2009), Australian oncologist and surgeon
Chris O'Brien (rugby union) (born 1964), United States rugby union player

See also
Christopher O'Brien (disambiguation)