Where in the body are the Kupffer Cells found?
Kupffer cell Kupffer cell Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized macrophages located in the liver, lining the walls of the sinusoids. They form part of the mononuclear phagocyte system. Their development begins in the yolk sac where they differentiate into fetal macrophages. Once they enter the blood stream, they migrate to the fetal liver where they stay. There they complete their differentiation into Kupffer cells. Apart from clearing any bacteria, red blood cells are also broken down by phagocytic action, where the hemoglobin molecule is split. The globin chains are re-utilized, while the iron-containing portion, heme,
Karl Wilhelm von Kupffer from Jagellonian University in Krakow, correctly identified them as macrophages. Karl Wilhelm von Kupffer Karl Wilhelm von Kupffer (14 November 1829 – 16 December 1902) was a Baltic German anatomist who discovered stellate macrophage cells that bear his name. He was the eldest son of pastor Karl Hermann Kupffer (1797-1860). In 1854, he obtained his medical doctorate from the University of Dorpat, where shortly afterwards he served as an assistant to Friedrich Heinrich Bidder (1810-1894). In 1856-57 he took a scientific journey to Vienna, Berlin and Göttingen, an extended trip in which he studied physiology with Emil Du Bois-Reymond (1818-1896)