From which creatures can Newcastle disease transfer to humans, causing mild conjunctivitis and flu symptoms?
Newcastle disease infected birds (for example in poultry processing plants) can cause mild conjunctivitis and influenza-like symptoms, but the Newcastle disease virus (NDV) otherwise poses no hazard to human health. Interest in the use of NDV as an anticancer agent has arisen from the ability of NDV to selectively kill human tumour cells with limited toxicity to normal cells. No treatment for NDV exists, but the use of prophylactic vaccines and sanitary measures reduces the likelihood of outbreaks. The causal agent, Newcastle disease virus (NDV), is a variant of avian paramyxovirus 1 (APMV-1), a negative-sense, single-stranded RNA virus. NDV/APMV-1 belong to the
Ligneous conjunctivitis Ligneous conjunctivitis Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich pseudomembranous lesions of wood-like consistency that develop mainly on the underside of the eyelid (tarsal conjunctiva). It is generally a systemic disease which may involve the periodontal tissue, the upper and lower respiratory tract, kidneys, middle ear, and female genitalia. It can be sight-threatening, and death can occasionally occur from pulmonary involvement. It has been speculated that ligneous conjunctivitis may be a manifestation of IgG4-related disease (IgG4-RD) involving the conjunctiva. Histopathological findings from affected humans indicate that wound healing is impaired due to a deficiency