Gamma-coniceine and coniine are the two principles which contribute most to the poisonous effect of what plant?
Coniine transamination using alanine:5-keto-octanal aminotransferase. The amine then spontaneously cyclizes and is dehydrated to form the coniine precursor γ–coniceine. This is then reduced using NADPH dependent y-coniceine reductase to form coniine. Coniine is the murder weapon in Agatha Christie's mystery novel "Five Little Pigs". Coniine Coniine refers to a poisonous chemical compound, an alkaloid present in and isolable from poison hemlock ("Conium maculatum"), where its presence has been a source of significant economic, medical, and historico-cultural interest; coniine is also produced by the yellow pitcher plant ("Sarracenia flava"), and fool's parsley ("Aethusa cynapium"). Its ingestion and extended exposure are toxic to
Coniine coniine have been effected, of which that of Diels and Alder is of special interest. The initial adduct of pyridine and dimethyl acetylenedicarboxylate is tetramethylquinolizine-1,2,3,4-tetracarboxylate, which on oxidation with dilute nitric acid is converted into trimethyl indolizine-tricarboxylate. This, on hydrolysis and decarboxylation, furnishes indolizine, the octahydro-derivate of which, also known as octahydropyrrocoline is converted by the cyanogen bromide method successively into the bromocyanoamide, cyanoamide and "rac."-coniine. A synthesis of the alkaloid, starting from indolizine (pyrrocoline) is described by Ochiai and Tsuda. The preparation of -("R")-coniine by the reduction of β-coniceine (-propenylpiperidine) by Löffler and Friedrich is interesting as a means