What substance is formed through ossification?
Endochondral ossification bone until its ultimate thickness is achieved, at which point the rate of formation on the outside and degradation from the inside is constant. During endochondral ossification, five distinct zones can be seen at the light-microscope level. During fracture healing, cartilage is often formed and is called callus. This cartilage ultimately develops into new bone tissue through the process of endochondral ossification. Recently it has been shown that biomimetic bone like apatite inhibits formation of bone through endochondral ossification pathway via hyperstimulation of extracellular calcium sensing receptor (CaSR). Endochondral ossification Endochondral ossification is one of the two essential processes during
Ossification center the epiphyses. Ossification center The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed as an ossification center, enlarge and arrange themselves in rows. The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other. A deposit of calcareous material now takes place in this matrix, between the rows of cells, so that they become separated from each other by longitudinal columns of calcified matrix, presenting a granular and opaque appearance. Here and there the matrix between