Which virus, which interferes with the endothelial cells lining the interior surface of blood vessels and coagulation causing hypovolemic shock, first emerged in 1976 in Zaire and came to international attention in 1989 after a widely publicized outbreak in Virginia, USA?
Ebola virus time, a third team introduced the name "Ebola virus", derived from the Ebola River where the 1976 outbreak occurred. The International Committee on Taxonomy of Viruses (ICTV) identifies Ebola virus as species "Zaire ebolavirus", which is included into the genus "Ebolavirus", family "Filoviridae", order "Mononegavirales". The name "Ebola virus" is derived from the Ebola River—a river that was at first thought to be in close proximity to the area in Democratic Republic of Congo, previously called Zaire, where the 1976 Zaire Ebola virus outbreak occurred—and the taxonomic suffix "virus". In 2000, the virus name was changed to Zaire Ebola virus,
Distributive shock and others with normal to high blood flow. The endothelial cells lining the blood vessels become less responsive to vasocontrictive agents, lose their glycocalyx (normal coating) and negative ionic charge, become leaky and cause extensive over-expression of nitric oxide. The coagulation cascade is also disrupted. Tissue factor that initiates the clotting cascade is produced by activated monocytes and the endothelial cells lining the blood vessels while antithrombin and fibrinolysis are impaired. Disseminated intravascular coagulation (DIC) can result from the thrombin produced in the inflammatory response. The ability of red blood cells to change shape decreases and their tendency to clump