"in 1853 while working on the synthesis and properties of various acid anhydrides, French chemist Charles Frederic Gerhardt made acetylsalicylic acid by mixing acetyl chloride with a sodium salt of salicylic acid (sodium salicylate). He called the resulting compound ""salicylic-acetic anhydride"". What was this preparation later marketed as?"
History of aspirin work on the synthesis and properties of various acid anhydrides, he mixed acetyl chloride with a sodium salt of salicylic acid (sodium salicylate). A vigorous reaction ensued, and the resulting melt soon solidified. Since no structural theory existed at that time Gerhardt called the compound he obtained "salicylic-acetic anhydride" ("wasserfreie Salicylsäure-Essigsäure"). When Gerhardt tried to dissolve the solid in a diluted solution of sodium carbonate it immediately decomposed to sodium salts of salicylic and acetic acids. In 1859 an Austrian chemist, Hugo von Gilm, obtained analytically pure acetylsalicylic acid (which he called "acetylierte Salicylsäure", acetylated salicylic acid) by a reaction
Salicylic acid increase in efficacy. Some people are hypersensitive to salicylic acid and related compounds. If high concentrations of salicylic ointment are applied to a large percentage of body surface, high levels of salicylic acid can enter the blood, requiring hemodialysis to avoid further complications. Salicylic acid is biosynthesized from the amino acid phenylalanine. In "Arabidopsis thaliana" it can be synthesized via a phenylalanine-independent pathway. Sodium salicylate is commercially prepared by treating sodium phenolate (the sodium salt of phenol) with carbon dioxide at high pressure (100 atm) and high temperature (390 K) – a method known as the Kolbe-Schmitt reaction. Acidification of