The development of the immuno-suppressant drug ciclosporin in the 1980s gave a fillip to what type of surgeries?
Ciclosporin an ophthalmic ointment for dogs called Optimmune, manufactured by Intervet, which is part of Merck. It is also used to treat sebaceous adenitis (immune response against the sebaceous glands), pemphigus foliaceus (autoimmune blistering skin disease), Inflammatory bowel disease, anal furunculosis (anal inflammatory disease), and myasthenia gravis (a neuromuscular disease). It is sometimes prescribed for extreme cases of immune-mediated hemolytic anemia. Ciclosporin Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is taken by mouth or by injection into a vein for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection.
Inhaled ciclosporin the vehicle for administration by nebulizer or have used more complicated aqueous-based formulations involving liposomes or other dispersions. Dry powder inhaler as well as propellant metered dose inhaler (pMDI) formulations have also been created and evaluated in the laboratory and in early clinical studies. Ciclosporin was brought to market in 1983 but the first non human aerosol studies were not published until the late 1980s. These efforts probed the anti-inflammatory and immunosuppressive properties of ciclosporin after regional deposition of drug in the lungs. Ciclosporin has been touted as a therapeutic option in moderate to severe asthmatic patients as a corticosteroid