What soluble form of Aspirin was invented during World War II?
History of aspirin "Bayer Aspirin" made up only a small fraction of the British aspirin market because of competition from "Aspro", "Disprin" (a soluble aspirin drug) and other brands. Bayer Ltd began searching for new pain relievers to compete more effectively. After several moderately successful compound drugs that mainly utilized aspirin ("Anadin" and "Excedrin"), Bayer Ltd's manager Laurie Spalton ordered an investigation of a substance that scientists at Yale had, in 1946, found to be the metabolically active derivative of acetanilide: acetaminophen. After clinical trials, Bayer Ltd brought acetaminophen to market as "Panadol" in 1956. However, Sterling Products did not market "Panadol" in
History of aspirin products such "Cafaspirin" (aspirin with caffeine) and "Alka-Seltzer" (a soluble mix of aspirin and bicarbonate of soda) put aspirin to new uses. In 1925, the German Bayer became part of IG Farben, a conglomerate of former dye companies; IG Farben's brands of "Aspirin" and, in Latin America, the caffeinated "Cafiaspirina" (co-managed with Sterling Products) competed with less expensive aspirins such as "Geniol". After World War II, with the IG Farben conglomerate dismantled because of its central role in the Nazi regime, Sterling Products bought half of Bayer Ltd, the British Bayer subsidiary—the other half of which it already owned. However,