James Herrick is credited with the description of a genetic disease in which red-blood cells are in what shape instead of the normal disc shape?
Pleiotropy to have protein. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal flexible, round shape. It is caused by a change in one nucleotide, a point mutation in the HBB gene. The HBB gene encodes information to make the beta-globin subunit of hemoglobin, which is the protein red blood cells use to carry oxygen throughout the body. Sickle cell anemia occurs when the HBB gene mutation causes both beta-globin subunits of hemoglobin to change into hemoglobinS (HbS). Sickle cell anemia is a pleiotropic disease because the expression
Biconcave disc Biconcave disc A biconcave disc is a geometric shape resembling an oblate spheroid with two concavities on the top and on the bottom. Erythrocytes are in the shape of a biconcave disc. It has been suggested that this shape is optimal for surface area to volume ratio, but this hypothesis has not been widely accepted. In addition, it has been suggested that the biconcave shape is needed to optimise the blood's flow properties. Biconcave shape of the red blood cells. Mammalian red blood cells also known as erythrocyte are a cellular component of the blood which give the blood its