Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
Jacobite line of succession to the English and Scottish thrones in 1714 succession crisis which ultimately led to an Act of Parliament to designate Anne's successor. The Act of Settlement, drawn up in 1701, settled the succession on Sophia of the Palatinate, Electress of Hanover, and the heirs of her body, barring any Roman Catholics or spouses of Roman Catholics from the succession. This was a deliberate attempt to disinherit Anne's nearest blood relation, the exiled Roman Catholic James Stuart (who would later be known as the 'Old Pretender'), her half-brother, from inheriting the throne. The Act changed the course of British history and had many political consequences, primarily leading to the