Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and the English Parliament James VI and I and the English Parliament James I, the first king to reign in both England and Scotland, faced many difficulties with the Parliament of England. Though recent studies have shown that the Parliament of Scotland may have been more of a thorn in his side than was previously believed, James developed his political philosophy of the relationship between monarch and parliament in Scotland and never reconciled himself to the independent stance of the English Parliament and its unwillingness to bow readily to his policies. The crucial source of concern was that the King and Parliament adhered to