Berkeley Hundred and 17 days before the Pilgrims arrived aboard the "Mayflower" at Plymouth, Massachusetts to establish their Thanksgiving Day in 1621. On March 22, 1622, Opchanacanough, head of the Powhatan Confederacy, began the Second Anglo-Powhatan War with a coordinated series of attacks against English settlements along the James River, known in English histories as the Indian massacre of 1622. Nine colonists were killed at Berkeley. The assault took a heavier toll elsewhere, killing about a third of all the colonists, and virtually wiping out Wolstenholme Towne on Martin's Hundred and Sir Thomas Dale's progressive development and new college at Henricus. Jamestown
Matanzas Inlet inlet, the southernmost access for boat travel between St. Augustine and Havana, Cuba. Shortly thereafter, in 1742, a coquina stone tower square by high, now called Fort Matanzas, was built by the Spanish authorities in Florida to safeguard this strategic inlet. René Goulaine de Laudonnière founded Fort Caroline in what is now Jacksonville, in 1564, as a haven for Huguenot settlers. In response to the French encroachment on what Spain regarded as its territory, Pedro Menéndez de Avilés founded St. Augustine in 1565. Menéndez de Avilés quickly set out to attack Fort Caroline, traveling overland from St. Augustine. At the