Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such as dicyclohexylcarbodiimide (DCC) in peptide synthesis. It acts as a neutralizing reagent for the basicity or nucleophilicity of the DCC due to its pronounced acidity (pKa 4.60) and suppresses base catalyzed side reactions, in particular racemization. Ethyl cyanohydroxyiminoacetate is obtained in the reaction of ethyl cyanoacetate and nitrous acid (from sodium nitrite and acetic acid) in 87% yield. Because of the rapid hydrolysis of the ester, the reaction should be carried out at pH 4.5, in buffered phosphoric acid the
Ethyl Corporation In 2004, Ethyl Corporation became a subsidiary of NewMarket Corporation (). Tetraethyllead has been recognized as a contributor to soil, air and water lead pollution, and is toxic to humans. While leaded gasoline made engines more efficient, lead pollution has increased by over 625 times previous levels in the past century due partly to pollution by leaded fuel. Ethyl Corporation historically denied that tetraethyllead poses significant public health risks in excess of those associated with gasoline itself. Tetraethyllead was supplied for blending with raw gasoline in the form of "Ethyl Fluid", which blended tetraethyllead with the lead scavengers 1,2-dibromoethane and