Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
Near to the Wild Heart read the originals chapter by chapter, but Clarice vividly rejected his occasional suggestions: “When I reread what I’ve written,” she told him, “I feel like I’m swallowing my own vomit.” Cardoso suggested a title, borrowed from James Joyce’s "Portrait of the Artist as a Young Man": “He was alone. He was unheeded, happy, and near to the wild heart of life.” This became the book’s epigraph, which, together with the occasional use of the stream-of-consciousness method, led certain critics to describe the book as “Joycean.” The comparison annoyed Lispector, who had not read Joyce; instead, the book bears the much