Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of the central nervous system. The disease is characterised by bilateral diffuse uveitis, with pain, redness and blurring of vision. The eye symptoms may be accompanied by a varying constellation of systemic symptoms, such as auditory (tinnitus, vertigo, and hypoacusis), neurological
Tinnitus masker wide band white or pink noise, narrow band white noise, a notched soundfield, frequency or amplitude modulated sound, intermittent pulsed sound, or other patterned sound. Temporally patterned sound may be more effective than white noise or background music in masking tinnitus. Studies have found that bandpass maskers are less annoying than pure tone maskers, that the annoyance rating of bandpass maskers is proportional to bandwidth, that intermittent maskers were more annoying than continuous ones, and that control over the center frequency and bandwidth was important in minimizing the annoyance of maskers. In addition to the spectrum of masking sound, the