Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and the English Parliament session on 5 November 1605, a soldier called Guy Fawkes was discovered in the cellars of the parliament buildings guarding a pile of slaves, not far from about twenty barrels of gunpowder with which he intended to blow up Parliament House the following day and cause the destruction, as James put it, "not only...of my person, nor of my wife and posterity also, but of the whole body of the State in general". A Catholic conspiracy led by a disaffected gentleman called Robert Catesby, the Gunpowder Plot, as it quickly became known, had in fact been discovered in advance of