Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
To Have and to Hold To Have and to Hold To Have and to Hold (1899) is a novel by American author Mary Johnston. Published by Houghton Mifflin, it was the bestselling novel in the United States in the following year (1900). "To Have and to Hold" is the story of an English soldier, Ralph Percy, turned Virginian explorer in colonial Jamestown. Ralph buys a wife for himself - a girl named Jocelyn Leigh - little knowing that she is the escaping ward of King James I, fleeing a forced marriage to Lord Carnal. Jocelyn hardly loves Ralph - indeed, she seems to abhor him.