Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
Descendants of James VI and I in 1603, Anne was the mother of three living children (Henry Frederick, Prince of Wales, Elizabeth and Charles), but had also suffered at least three miscarriages and stillbirths, and had another four children who died in infancy. Their second son succeeded James as King Charles I. Elizabeth was the eldest daughter of James VI and I, and the sister of King Charles I. Among her suitors was King Gustavus Adolphus of Sweden, but she was eventually betrothed to Frederick V, then Elector of the Electorate of the Palatinate in Germany, in 1612. On 14 February 1613, they married and she