Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and the English Parliament of Middlesex, when he opposed the idea on grounds of cost. The outcome of the Parliament of 1624 was ambiguous: James still refused to declare war, but Charles believed the Commons had committed themselves to financing a war against Spain, a stance which was to contribute to his problems with Parliament in his own reign. James VI and I and the English Parliament James I, the first king to reign in both England and Scotland, faced many difficulties with the Parliament of England. Though recent studies have shown that the Parliament of Scotland may have been more of a thorn