The Description of the Human Body He believed the heat of the heart somehow caused all movement of the body. Blood vessels he realized were pipes, he saw that veins carried digested food to the heart. (This was brought further by William Harvey. Harvey developed the idea of the circulation of the blood.) Descartes felt that an energetic part of blood went to the brain and there gave the brain a special type of air imbued with vital force that enabled the brain to experience, think and imagine. This special air then went through the nerves to the muscles enabling them to move. The Description of
Drug delivery to the brain because most molecules are transported across the barrier, it does a very effective job of maintaining homeostasis for the most vital organ of the human body. Because of the difficulty for drugs to pass through the blood–brain barrier, a study was conducted to determine the factors that influence a compound’s ability to transverse the blood–brain barrier. In this study, they examined several different factors to investigate diffusion across the blood–brain barrier. They used lipophilicity, Gibbs Adsorption Isotherm, a Co CMC Plot, and the surface area of the drug to water and air. They began by looking at compounds whose blood–brain