Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such as dicyclohexylcarbodiimide (DCC) in peptide synthesis. It acts as a neutralizing reagent for the basicity or nucleophilicity of the DCC due to its pronounced acidity (pKa 4.60) and suppresses base catalyzed side reactions, in particular racemization. Ethyl cyanohydroxyiminoacetate is obtained in the reaction of ethyl cyanoacetate and nitrous acid (from sodium nitrite and acetic acid) in 87% yield. Because of the rapid hydrolysis of the ester, the reaction should be carried out at pH 4.5, in buffered phosphoric acid the
Ethyl sulfate the according carbonate, or bicarbonate salt. As an example, ethyl sulfate and potassium carbonate forms potassium ethyl sulfate and potassium bicarbonate. Ethyl sulfate Ethyl sulfate (IUPAC name: ethyl hydrogen sulfate), also known as sulfovinic acid, is an organic chemical compound used as an intermediate in the production of ethanol from ethylene. It is the ethyl ester of sulfuric acid. This substance was studied alongside ether for the first time by German alchemist August Siegmund Frobenius in 1730, subsequently by French chemists Fourcroy in 1797 and Gay-Lussac in 1815. Swiss scientist Nicolas-Théodore de Saussure also studied it in 1807. In 1827,