Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and the English Parliament the delight of the British people. Embittered by their treatment in Spain, Charles and Buckingham now turned James’s Spanish policy upon its head and called for a French match and a war against the Habsburg empire. To raise the necessary finance, they prevailed upon James to call another Parliament, which met in February 1624. For once, the outpouring of anti-Catholic sentiment in the Commons was echoed in court, where control of policy had shifted from James to Charles and Buckingham, who pressured the king to declare war and engineered the impeachment and imprisonment of the Lord Treasurer, Lionel Cranfield, earl