William Harvey was also an intense and dedicated observer of birds during his free time: several long and detailed passages of citations could be written delineating his observations in such places as the "Pile of Boulders" (a small island in Lancashire) and 'Bass Rock' (island off the East Coast of Scotland). William Harvey William Harvey (1 April 1578 – 3 June 1657) was an English physician who made seminal contributions in anatomy and physiology. He was the first known physician to describe completely, and in detail, the systemic circulation and properties of blood being pumped to the brain and body by the
Drug delivery to the brain because most molecules are transported across the barrier, it does a very effective job of maintaining homeostasis for the most vital organ of the human body. Because of the difficulty for drugs to pass through the blood–brain barrier, a study was conducted to determine the factors that influence a compound’s ability to transverse the blood–brain barrier. In this study, they examined several different factors to investigate diffusion across the blood–brain barrier. They used lipophilicity, Gibbs Adsorption Isotherm, a Co CMC Plot, and the surface area of the drug to water and air. They began by looking at compounds whose blood–brain