Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
Open Up Your Heart (And Let the Sunshine In) two measures to the published version of Aloha Oe by Princess Lili`uokalani (1878), and "There's Music In the Air" by George F. Root (1854), and all three share the same chord progression IV-I-V-I. The 1969 #1 hit song Aquarius/Let the Sunshine In by The 5th Dimension contains the refrain "Let the Sunshine In" and backing vocals that include the phrase "Open Up Your Heart". Open Up Your Heart (And Let the Sunshine In) "Open up Your Heart (and Let the Sunshine in)" is a popular song. It was written by Stuart Hamblen. The song was published in 1954. The biggest