Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I peace and comparatively low taxation during the Jacobean era. "As he lived in peace," remarked the Earl of Kellie, "so did he die in peace, and I pray God our king [Charles I] may follow him". The earl prayed in vain: once in power, Charles and Buckingham sanctioned a series of reckless military expeditions that ended in humiliating failure. James had often neglected the business of government for leisure pastimes, such as the hunt; and his later dependence on favourites at a scandal-ridden court undermined the respected image of monarchy so carefully constructed by Elizabeth. Under James the Plantation of