Berkeley Hundred and 17 days before the Pilgrims arrived aboard the "Mayflower" at Plymouth, Massachusetts to establish their Thanksgiving Day in 1621. On March 22, 1622, Opchanacanough, head of the Powhatan Confederacy, began the Second Anglo-Powhatan War with a coordinated series of attacks against English settlements along the James River, known in English histories as the Indian massacre of 1622. Nine colonists were killed at Berkeley. The assault took a heavier toll elsewhere, killing about a third of all the colonists, and virtually wiping out Wolstenholme Towne on Martin's Hundred and Sir Thomas Dale's progressive development and new college at Henricus. Jamestown
Raid on St. Augustine town overnight and the following day razed the whole of St. Augustine to the ground. All buildings were torched, crops were destroyed and anything of value was either taken or destroyed. The fort of San Juan was burnt and all the artillery pieces were carried away by the English among other booty. Once the English had gone Menéndez and the rest of the Spanish settlers returned to find a smoldering ruins and very little left of their settlement. He soon begged for help from the viceroy of Cuba and the settlement took a while to build itself back up. The