Berkeley Hundred and 17 days before the Pilgrims arrived aboard the "Mayflower" at Plymouth, Massachusetts to establish their Thanksgiving Day in 1621. On March 22, 1622, Opchanacanough, head of the Powhatan Confederacy, began the Second Anglo-Powhatan War with a coordinated series of attacks against English settlements along the James River, known in English histories as the Indian massacre of 1622. Nine colonists were killed at Berkeley. The assault took a heavier toll elsewhere, killing about a third of all the colonists, and virtually wiping out Wolstenholme Towne on Martin's Hundred and Sir Thomas Dale's progressive development and new college at Henricus. Jamestown
History of the Southern United States now Virginia and Maryland. It preceded Jamestown, the English colony, by as much as one hundred years. The first French settlement in what is now the Southern United States was Fort Caroline, located in what is now Jacksonville, Florida, in 1562. It was established as a haven for the Huguenots and was founded under the leadership of René Goulaine de Laudonnière and Jean Ribault. It was destroyed by the Spanish from the nearby colony of St. Augustine in 1565. Later French arrived from the north. Having established agricultural colonies in Canada and built a fur trading network with Indians in