Berkeley Hundred and 17 days before the Pilgrims arrived aboard the "Mayflower" at Plymouth, Massachusetts to establish their Thanksgiving Day in 1621. On March 22, 1622, Opchanacanough, head of the Powhatan Confederacy, began the Second Anglo-Powhatan War with a coordinated series of attacks against English settlements along the James River, known in English histories as the Indian massacre of 1622. Nine colonists were killed at Berkeley. The assault took a heavier toll elsewhere, killing about a third of all the colonists, and virtually wiping out Wolstenholme Towne on Martin's Hundred and Sir Thomas Dale's progressive development and new college at Henricus. Jamestown
Berkeley Plantation American "firsts" that occurred at Berkeley Plantation are: On December 4, 1619, a group of 38 English settlers arrived at Berkeley Hundred, about on the north bank of the James River near Herring Creek in an area then known as Charles Cittie (sic). It was named for one of the original founders, Richard Berkeley, a member of the Berkeley family of Gloucestershire, England. It was about 20 miles upstream from Jamestown, where the first permanent settlement of the Colony of Virginia was established on May 14, 1607. The group's London Company charter required that the day of arrival be observed