Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and the English Parliament without Parliament since the "Addled Parliament" of 1614, which he had dissolved after eight weeks when it proved reluctant to grant him money. Buckingham addressed the search for alternative revenues, employing officials, such as the businessman Lionel Cranfield, who were astute in raising and saving money for the Crown. Cash was also raised by selling earldoms and other dignities, many created by James himself. Another potential source of income was the prospect of a Spanish dowry from a marriage between Charles, Prince of Wales and the Spanish Infanta, Maria. The policy of the Spanish Match, as it was called, was