The Florida Wildlife Corridor Expedition the Okaloacoochee Slough, across the Caloosahatchee River, over to Babcock Ranch, and west along Fisheating Creek toward Lake Okeechobee. From Lake Okeechobee, the heart of the Greater Everglades system, the Expedition traveled up the Kissimmee River with excursions toward the Lake Wales Ridge, up the Kissimmee Chain of Lakes, east around Orlando, and into Ocala National Forest. Once in the existing Ocala to Osceola corridor, the trip continued north in Georgia and into the Okefenokee National Wildlife Refuge. The vision for the second Florida Wildlife Corridor Expedition is to connect natural lands and waters throughout the northwest region of Florida,
Lake Okeechobee that the lake's water quality was a State issue. The Florida Department of Environmental Protection and Martin County had carried out toxicity testing on the algae, but had not funded any work to clean up the water, and a FEMA spokesman said that "The state has robust capability to respond to emergencies and disasters." On June 23, 2017, the South Florida Water Management District was granted emergency permission to back pump clean water into Lake Okeechobee to save animals and plants in bloated water conservation areas." Lake Okeechobee sits in a shallow geological trough that also underlies the Kissimmee River