Les Demoiselles d'Avignon Les Demoiselles d'Avignon Les Demoiselles d'Avignon (The Young Ladies of Avignon, and originally titled The Brothel of Avignon) is a large oil painting created in 1907 by the Spanish artist Pablo Picasso. The work, part of the permanent collection of the Museum of Modern Art, portrays five nude female prostitutes from a brothel on Carrer d'Avinyó (Avignon Street) in Barcelona. Each figure is depicted in a disconcerting confrontational manner and none is conventionally feminine. The women appear as slightly menacing and rendered with angular and disjointed body shapes. Three figures on the left exhibit facial features in the Iberian style
Alternative explanations of the "grandmother" cell a study performed by Logothetis and Pauls, this is seen with the spiking of a single macaque monkey neuron when presented with a paper clip bent in a certain way at a variety of angles. At a specific angle, the neuron fires rapidly. At different angles or shapes, it does not. A grandmother cell, by contrast, would seem to fire at many different shapes and angles. And it is very difficult to imagine what kind of mechanism "will bind ... information from disparate sensory sources" in a cell, which makes a grandmother cell "a tremendous connectivity puzzle". In 2001, Kreiman