Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of the central nervous system. The disease is characterised by bilateral diffuse uveitis, with pain, redness and blurring of vision. The eye symptoms may be accompanied by a varying constellation of systemic symptoms, such as auditory (tinnitus, vertigo, and hypoacusis), neurological
Mind–body dualism main objections to dualistic interactionism is lack of explanation of how the material and immaterial are able to interact. Varieties of dualism according to which an immaterial mind causally affects the material body and vice versa have come under strenuous attack from different quarters, especially in the 20th century. Critics of dualism have often asked how something totally immaterial can affect something totally material—this is the basic "problem of causal interaction". First, it is not clear "where" the interaction would take place. For example, burning one's finger causes pain. Apparently there is some chain of events, leading from the burning