Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and the English Parliament James flatly told them not to interfere in matters of royal prerogative or they would risk punishment; to which provocation they reacted by issuing a statement protesting their rights, including freedom of speech. Urged on by Buckingham and the Spanish ambassador Gondomar, James ripped the protest out of the record book and dissolved Parliament. Denied the military option, James ignored public opinion and returned to the Spanish match as his only hope of restoring the possessions of Elizabeth and Frederick. When negotiations began to drag, Prince Charles, now 23, and Buckingham, decided to seize the initiative and travel to Spain