Thomas Howard, 3rd Duke of Norfolk wed Norfolk's other niece, Catherine Howard, as his fifth wife. As a result of this marriage, for a time, Norfolk enjoyed political prominence, royal favour, and material rewards. However, when Queen Catherine's premarital sexual indiscretions and her alleged adultery with Sir Thomas Culpeper were revealed to King Henry VIII by Archbishop Cranmer, the King's wrath turned on the Howard family, who were accused of concealing her misconduct. Queen Catherine Howard was condemned by a bill of attainder and was later executed on 13 February 1542. Several other members of the Howard family were sent to the Tower, including Norfolk's stepmother,
Catherine of Siena court and writing letters to persuade others. For many years she had accustomed herself to a rigorous abstinence. She received the Holy Eucharist almost daily. This extreme fasting appeared unhealthy in the eyes of the clergy and her own sisterhood. Her confessor, Blessed Raymond, ordered her to eat properly. But Catherine claimed that she was unable to, describing her inability to eat as an "infermità" (illness). From the beginning of 1380, Catherine could neither eat nor swallow water. On February 26 she lost the use of her legs. Catherine died in Rome, on 29 April 1380, at the age of