Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
Pinky and the Brain more eloquent manner, Pinky has a straight tail, blue eyes, and a severe overbite, is taller than the Brain, and speaks in a high pitched voice with a cockney accent. Pinky's name was inadvertently given to him by Brain himself: when insulting the two scientists responsible for their gene splicing while talking to himself, Brain claimed the scientists had "less knowledge in both their heads than I do in my... pinky!" Pinky then responded with "Yes?", believing Brain was referring to him. Pinky is more open-minded, kinder, and happier than the Brain. Troubles never ruin his day, arguably because he