Femur the medial, gives attachment to the fibular collateral ligament of the knee-joint. The femur develops from the limb buds as a result of interactions between the ectoderm and the underlying mesoderm, formation occurs roughly around the fourth week of development. By the sixth week of development, the first hyaline cartilage model of the femur is formed by chondrocytes. Endochondral ossification begins by the end of the embryonic period and primary ossification centers are present in all long bones of the limbs, including the femur, by the 12th week of development. The hindlimb development lags behind forelimb development by 1–2 days.
Femur the bone. Some species of whales, snakes, and other non-walking vertebrates have vestigial femurs. One of the earliest known vertebrates to have a femur is the "eusthenopteron", a prehistoric lobe-finned fish from the Late Devonian period. Structures analogous to the third trochanter are present in mammals, including some primates. In invertebrate zoology the name "femur" appears in arthropodology. The usage is not homologous with that of vertebrate anatomy; the term "femur" simply has been adopted by analogy and refers, where applicable, to the most proximal of (usually) the two longest jointed segments of the legs of the arthropoda. The two