Abstract art based on Cézanne's idea that all depiction of nature can be reduced to three solids: cube, sphere and cone. With the painting "Les Demoiselles d'Avignon" (1907), Picasso dramatically created a new and radical picture depicting a raw and primitive brothel scene with five prostitutes, violently painted women, reminiscent of African tribal masks and his own new Cubist inventions. Analytic cubism was jointly developed by Pablo Picasso and Georges Braque, from about 1908 through 1912. Analytic cubism, the first clear manifestation of cubism, was followed by Synthetic cubism, practiced by Braque, Picasso, Fernand Léger, Juan Gris, Albert Gleizes, Marcel Duchamp and
Alternative explanations of the "grandmother" cell a study performed by Logothetis and Pauls, this is seen with the spiking of a single macaque monkey neuron when presented with a paper clip bent in a certain way at a variety of angles. At a specific angle, the neuron fires rapidly. At different angles or shapes, it does not. A grandmother cell, by contrast, would seem to fire at many different shapes and angles. And it is very difficult to imagine what kind of mechanism "will bind ... information from disparate sensory sources" in a cell, which makes a grandmother cell "a tremendous connectivity puzzle". In 2001, Kreiman