Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
When I Was One-and-Twenty that he understands the consequences, which is a broken heart, but shows no desire to the reader of preventing it. In the poem, the character is warned not to give his heart away out of lust, but to guard it with care as it is shown in this quote from the poem, “Give crowns and pounds and guineas, but not your heart away” (3-4). When the end of the poem is reached, the reader then understands the intention of the poem was not blithe, but the opposing adjective as Housman writes “I am two-and-twenty and oh ’tis true ’tis true”