Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and the English Parliament Fawkes's arrest and deliberately allowed to mature in order to catch the culprits red-handed and the plotters unawares. James's difficulties with the Commons and his waning public popularity notwithstanding, the sensational discovery of the Gunpowder Plot aroused a potent wave of national relief at the delivery of the king and his sons and inspired in the ensuing parliament a mood of loyalty and goodwill which Salisbury astutely exploited to extract higher subsidies for the king than any but one granted in Elizabeth's reign. In his speech to both houses on 9 November, James expounded on two emerging preoccupations of his