William Harvey William Harvey William Harvey (1 April 1578 – 3 June 1657) was an English physician who made seminal contributions in anatomy and physiology. He was the first known physician to describe completely, and in detail, the systemic circulation and properties of blood being pumped to the brain and body by the heart, though earlier writers, such as Realdo Colombo, Michael Servetus, and Jacques Dubois, had provided precursors of the theory. In 1973, the William Harvey Hospital was constructed in the town of Ashford, a few miles from his birthplace of Folkestone. William's father, Thomas Harvey, was a jurat of Folkestone
Nanoparticles for drug delivery to the brain treatment of various diseases. For example, one study has shown that using focused ultrasound with oscillating bubbles loaded with a chemotherapeutic drug, carmustine, facilitates the safe treatment of glioblastoma in an animal model. This drug, like many others, normally requires large dosages to reach the target brain tissue diffusion from the blood, leading to systemic toxicity and the possibilities of multiple harmful side effects manifesting throughout the body. However, focused ultrasound has the potential to increase the safety and efficacy of drug delivery to the brain. A study was performed to assess the toxicity effects of doxorubicin-loaded polymeric nanoparticle systems.