Ethyl acetate Fischer equilibrium mentioned above. In the laboratory, and usually for illustrative purposes only, ethyl esters are typically hydrolyzed in a two-step process starting with a stoichiometric amount of a strong base, such as sodium hydroxide. This reaction gives ethanol and sodium acetate, which is unreactive toward ethanol: The rate constant is 0.111 L/mol·s at 25 °C. The for rats is 5620 mg/kg, indicating low toxicity. Given that the chemical is naturally present in many organisms, there is little risk of toxicity. Overexposure to ethyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness,
Ethyl cyanoacetate This reactivity is similar to that of esters of malonic acid. As an example of reactivity at the nitrile, diethyl malonate is obtained from cyanoacetic acid ethyl ester by reaction with ethanol in the presence of strong acids. Heating in the presence of sodium ethoxide forms the dimeric 3-amino-2-cyano-2-pentendiaciddiethylester. Due to its functionality cyanoacetate reacts: Ethyl cyanoacetate is a building block for the synthesis of heterocycles which are used for example as drugs: Also many other functional heterocycles are in good yields accessible from ethyl cyanoacetate, such as 3-substituted coumarin derivatives. Non-cyclic products from this starting material include: Ethyl cyanoacetate