History of electromagnetic theory used to create positively charged anodes and negatively charged cathodes. When a conductor was attached between these, the difference in the electrical potential (also known as voltage) drove a current between them through the conductor. The potential difference between two points is measured in units of volts in recognition of Volta's work. The first mention of voltaic electricity, although not recognized as such at the time, was probably made by Johann Georg Sulzer in 1767, who, upon placing a small disc of zinc under his tongue and a small disc of copper over it, observed a peculiar taste when the
Transepithelial potential difference increased in cystic fibrosis, making it a potential diagnostic tool for this disorder. In the kidney, TEPD contributes to tubular reabsorption. Transepithelial potential difference Transepithelial potential difference (TEPD) is the voltage across an epithelium, and is the sum of the membrane potentials for the outer and inner cell membranes. The diagnosis of Cystic Fibrosis (CF) is usually based on high sweat chloride concentrations, characteristic clinical findings (including sinopulmonary infections), and/or family history. However, a small portion of patients with Cystic Fibrosis especially those with "mild" mutations of the Cystic Fibrosis Transmembrane Regulator ion channel (CFTR), have near-normal sweat tests. In