Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such as dicyclohexylcarbodiimide (DCC) in peptide synthesis. It acts as a neutralizing reagent for the basicity or nucleophilicity of the DCC due to its pronounced acidity (pKa 4.60) and suppresses base catalyzed side reactions, in particular racemization. Ethyl cyanohydroxyiminoacetate is obtained in the reaction of ethyl cyanoacetate and nitrous acid (from sodium nitrite and acetic acid) in 87% yield. Because of the rapid hydrolysis of the ester, the reaction should be carried out at pH 4.5, in buffered phosphoric acid the
Ethyl Corporation 1,2-dichloroethane. Ethyl fluid contained a dye which would distinguish treated gasoline from untreated gasoline and discourage the diversion of gasoline for other purposes, such as cleaning. Ethyl Corporation Ethyl Corporation is a fuel additive company headquartered in Richmond, Virginia in the United States. The company is a distributor of fuel additives. Among other products, Ethyl Corporation distributes tetraethyllead, an additive used to make leaded gasoline. Founded in 1923, Ethyl Corp was formed by General Motors and Standard Oil of New Jersey (Esso). General Motors had the "use patent" for tetraethyllead (TEL) as an antiknock, based on the work of Thomas