Italian War of 1542–1546 and six decades of conflict. Italian War of 1542–1546 The Italian War of 1542–46 was a conflict late in the Italian Wars, pitting Francis I of France and Suleiman I of the Ottoman Empire against the Holy Roman Emperor Charles V and Henry VIII of England. The course of the war saw extensive fighting in Italy, France, and the Low Countries, as well as attempted invasions of Spain and England. The conflict was inconclusive and ruinously expensive for the major participants. The war arose from the failure of the Truce of Nice, which ended the Italian War of 1536–38, to
Siege of Perpignan (1542) Rheims; in the meantime, Charles attacked Wilhelm, invading the Duchy of Julich and capturing Düren. The Duke of Orléans captured Luxembourg on 10 September, but the French conquest was useless, and Luxembourg was recaptured by the Imperial troops under the Prince of Orange. The Duke of Jülich-Cleves-Berg surrendered on 7 September, signing the Treaty of Venlo with the Emperor. Siege of Perpignan (1542) The Siege of Perpignan took place in 1542, at Perpignan ("Spanish: Perpiñán"), between a larger French army commanded by Henry, Dauphin of France and the Spanish garrison at Perpignan. The Spaniards resisted until the arrival of the