Berkeley Hundred and 17 days before the Pilgrims arrived aboard the "Mayflower" at Plymouth, Massachusetts to establish their Thanksgiving Day in 1621. On March 22, 1622, Opchanacanough, head of the Powhatan Confederacy, began the Second Anglo-Powhatan War with a coordinated series of attacks against English settlements along the James River, known in English histories as the Indian massacre of 1622. Nine colonists were killed at Berkeley. The assault took a heavier toll elsewhere, killing about a third of all the colonists, and virtually wiping out Wolstenholme Towne on Martin's Hundred and Sir Thomas Dale's progressive development and new college at Henricus. Jamestown
Fugitive slaves in the United States first free settlement of former slaves in the Americas was Santa Teresa de Mosé, near St. Augustine, Florida. This community disbanded when Florida became a British possession in 1763, most of the slaves withdrawing to Cuba with the Spanish troops defending the San Marcos fort in Saint Augustine. Florida became a Spanish colony again in 1783, and it again became a fugitive slave destination. Heavy U.S. pressure caused Spain to rescind its formal welcoming of slaves, but it had little effect. Runaway slaves from as far as Virginia and Tennessee continued to emigrate to Florida, and the Spaniards, whose control