Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I and Prince and Great Steward of Scotland. He was baptised "Charles James" or "James Charles" on 17 December 1566 in a Catholic ceremony held at Stirling Castle. His godparents were Charles IX of France (represented by John, Count of Brienne), Elizabeth I of England (represented by the Earl of Bedford), and Emmanuel Philibert, Duke of Savoy (represented by ambassador Philibert du Croc). Mary refused to let the Archbishop of St Andrews, whom she referred to as "a pocky priest", spit in the child's mouth, as was then the custom. The subsequent entertainment, devised by Frenchman Bastian Pagez, featured men dressed