Ménière's disease the inner ear. The American Academy of Otolaryngology–Head and Neck Surgery Committee on Hearing and Equilibrium (AAO HNS CHE) set criteria for diagnosing Ménière's, as well as defining two sub-categories of Ménière's: cochlear (without vertigo) and vestibular (without deafness). In 1972, the Academy defined criteria for diagnosing Ménière's disease as: In 1985, this list changed to alter wording, such as changing "deafness" to "hearing loss associated with tinnitus, characteristically of low frequencies" and requiring more than one attack of vertigo to diagnose. Finally in 1995, the list was again altered to allow for degrees of the disease: In 2015, the
Niemann–Pick disease, SMPD1-associated clotting (platelets). The brain is not affected in Type B and the disease often presents in the pre-teen years. Niemann–Pick disease, SMPD1-associated Niemann–Pick disease, SMPD1-associated refers to two different types of Niemann–Pick disease which are associated with the SMPD1 gene. There are approximately 1,200 cases of NPA and NPB worldwide with the majority of cases being Type B or an intermediate form. Descriptions of type E and type F have been published, but they are not well characterized, and are currently classified under type B. Mutations in the SMPD1 gene cause Niemann–Pick Types A and B. This gene carries instructions