Berkeley Hundred and 17 days before the Pilgrims arrived aboard the "Mayflower" at Plymouth, Massachusetts to establish their Thanksgiving Day in 1621. On March 22, 1622, Opchanacanough, head of the Powhatan Confederacy, began the Second Anglo-Powhatan War with a coordinated series of attacks against English settlements along the James River, known in English histories as the Indian massacre of 1622. Nine colonists were killed at Berkeley. The assault took a heavier toll elsewhere, killing about a third of all the colonists, and virtually wiping out Wolstenholme Towne on Martin's Hundred and Sir Thomas Dale's progressive development and new college at Henricus. Jamestown
Hispanic and Latino Americans Portolà, Pedro Menéndez de Avilés, Álvar Núñez Cabeza de Vaca, Tristán de Luna y Arellano and Juan de Oñate, and non-Spanish explorers working for the Spanish Crown, such as Juan Rodríguez Cabrillo. In all, Spaniards probed half of today's lower 48 states before the first English colonization effort in 1585 at Roanoke Island off the East Coast. In 1565, the Spanish created the first permanent European settlement in the continental United States, at St. Augustine, Florida. Santa Fe, New Mexico was founded before Jamestown, Virginia (founded in 1607) and the New England Plymouth Colony (1620, of "Mayflower" and Pilgrims fame).