Ethyl acetate Fischer equilibrium mentioned above. In the laboratory, and usually for illustrative purposes only, ethyl esters are typically hydrolyzed in a two-step process starting with a stoichiometric amount of a strong base, such as sodium hydroxide. This reaction gives ethanol and sodium acetate, which is unreactive toward ethanol: The rate constant is 0.111 L/mol·s at 25 °C. The for rats is 5620 mg/kg, indicating low toxicity. Given that the chemical is naturally present in many organisms, there is little risk of toxicity. Overexposure to ethyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness,
Di-deuterated linoleic acid ethyl ester Di-deuterated linoleic acid ethyl ester Di-deuterated ethyl linoleate (also known as RT001; Di-deuterated linoleic acid ethyl ester, 11,11-D2-Ethyl Linoleate, Ethyl 11,11-D2-Linoleate) is an experimental, orally-bioavailable synthetic deuterated polyunsaturated fatty acid (PUFA), an isotopologue of an essential omega-6 PUFA, linoleic acid. The deuterated compound, while identical to natural linoleic acid, is resistant to lipid peroxidation which makes studies of its cell-protective properties worthwhile. Investigations of 11,11-D2-Ethyl linoleate (RT001) are being conducted in several neurological indications, including Friedreich’s ataxia and Infantile Neuroaxonal Dystrophy. A double-blind comparator-controlled Phase I/II clinical trial sponsored by Retrotope and Friedreich’s Ataxia Research Alliance was conducted to determine