Italian War of 1542–1546 and six decades of conflict. Italian War of 1542–1546 The Italian War of 1542–46 was a conflict late in the Italian Wars, pitting Francis I of France and Suleiman I of the Ottoman Empire against the Holy Roman Emperor Charles V and Henry VIII of England. The course of the war saw extensive fighting in Italy, France, and the Low Countries, as well as attempted invasions of Spain and England. The conflict was inconclusive and ruinously expensive for the major participants. The war arose from the failure of the Truce of Nice, which ended the Italian War of 1536–38, to
Catherine of Siena court and writing letters to persuade others. For many years she had accustomed herself to a rigorous abstinence. She received the Holy Eucharist almost daily. This extreme fasting appeared unhealthy in the eyes of the clergy and her own sisterhood. Her confessor, Blessed Raymond, ordered her to eat properly. But Catherine claimed that she was unable to, describing her inability to eat as an "infermità" (illness). From the beginning of 1380, Catherine could neither eat nor swallow water. On February 26 she lost the use of her legs. Catherine died in Rome, on 29 April 1380, at the age of