Femur the medial, gives attachment to the fibular collateral ligament of the knee-joint. The femur develops from the limb buds as a result of interactions between the ectoderm and the underlying mesoderm, formation occurs roughly around the fourth week of development. By the sixth week of development, the first hyaline cartilage model of the femur is formed by chondrocytes. Endochondral ossification begins by the end of the embryonic period and primary ossification centers are present in all long bones of the limbs, including the femur, by the 12th week of development. The hindlimb development lags behind forelimb development by 1–2 days.
Tibia taking an axial force during walking that is up to 4.7 bodyweight. Its bending moment in the sagittal plane in the late stance phase is up to 71.6 bodyweight times millimetre. Fractures of the tibia can be divided into those that only involve the tibia; bumper fracture, Segond fracture, Gosselin fracture, toddler's fracture, and those including both the tibia and fibula; trimalleolar fracture, bimalleolar fracture, Pott's fracture. In Judaism, the tibia, or shankbone, of a goat is used in the Passover Seder plate. The structure of the tibia in most other tetrapods is essentially similar to that in humans. The