Thanksgiving (United States) The most prominent historic thanksgiving event in American popular culture is the 1621 celebration at the Plymouth Plantation, where the settlers held a harvest feast after a successful growing season. Autumn or early winter feasts continued sporadically in later years, first as an impromptu religious observance and later as a civil tradition. The Plymouth settlers, known as Pilgrims, had settled in land abandoned when all but one of the Patuxet Indians died in a plague. After a harsh winter killed half of the Plymouth settlers, the last surviving Patuxet, Squanto (who had learned English and avoided the plague as a
History of Massachusetts of the Indian population before the first large-scale arrival of settlers in the 1630s. Large numbers of natives were decimated by virgin soil epidemics such as smallpox, measles, influenza, and perhaps leptospirosis, against which they had no immunity. In 1617–1619, smallpox killed 90% of the Native Americans in the region. The first English settlers in Massachusetts, the Pilgrims, established their settlement at Plymouth in 1620, and developed friendly relations with the native Wampanoag. This was the second successful permanent English colony in North America, after the Jamestown Colony. Before heading to the New World, they migrated to Holland to escape