Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I some symptoms. James described his urine to physician Théodore de Mayerne as being the "dark red colour of Alicante wine". The theory is dismissed by some experts, particularly in James's case, because he had kidney stones which can lead to blood in the urine, colouring it red. In early 1625, James was plagued by severe attacks of arthritis, gout, and fainting fits, and fell seriously ill in March with tertian ague and then suffered a stroke. He died at Theobalds House on 27 March during a violent attack of dysentery, with Buckingham at his bedside. James's funeral on 7 May