Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I witches and wrote "Daemonologie" in 1597, a tract inspired by his personal involvement that opposed the practice of witchcraft and that provided background material for Shakespeare's "Tragedy of Macbeth". James personally supervised the torture of women accused of being witches. After 1599, his views became more sceptical. In a later letter written in England to his son Henry, James congratulates the prince on "the discovery of yon little counterfeit wench. I pray God ye may be my heir in such discoveries ... most miracles now-a-days prove but illusions, and ye may see by this how wary judges should be in