Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I the crown's interest groups in Ireland, obtaining insufficient political benefit with his open-handed patronage, an unfortunate lack of attention to the image of monarchy (particularly after the image-obsessed regime of Elizabeth), pursuing a pro-Spanish foreign policy that fired religious prejudice and opened the door for Arminians within the English church, and enforcing unpalatable religious changes on the Scottish Kirk. Many of these criticisms are framed within a longer view of James' reigns, including the legacy – now understood to be more troubled – which he left Charles I. In Scotland, James was "James the sixth, King of Scotland", until 1604.