Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate Ethyl cyanohydroxyiminoacetate (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such as dicyclohexylcarbodiimide (DCC) in peptide synthesis. It acts as a neutralizing reagent for the basicity or nucleophilicity of the DCC due to its pronounced acidity (pKa 4.60) and suppresses base catalyzed side reactions, in particular racemization. Ethyl cyanohydroxyiminoacetate is obtained in the reaction of ethyl cyanoacetate and nitrous acid (from sodium nitrite and acetic acid) in 87% yield. Because of the rapid hydrolysis of the ester, the reaction should be carried out at pH 4.5, in buffered phosphoric acid the
Ethyl macadamiate similar to that of some silicone derivatives, however, Ethyl Macadamiate is non-volatile. Ethyl macadamiate is used in cosmetics, especially in skincare, haircare and suncare formulation. The dry skinfeel and high spread make ethyl macadamiate well suited for increasing sunscreen coverage. Ethyl macadamiate is an alternative to cyclomethicone and dimethicone as a skinfeel modifier where a botanical, nonvolatile and/or lipid-soluble substance is preferred. Ethyl macadamiate Ethyl macadamiate is the ester of ethyl alcohol and the fatty acids derived from "Macadamia terifolia" seed oil (q.v.). Ethyl macadamiate is commonly used in cosmetic formulations. Ethyl macadamiate is the ethyl ester of the free