Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
James VI and I Kingly Family of the House of Stuarts" (1652); Arthur Wilson's "History of Great Britain, Being the Life and Reign of King James I" (1658); and Francis Osborne's "Historical Memoirs of the Reigns of Queen Elizabeth and King James" (1658). David Harris Willson's 1956 biography continued much of this hostility. In the words of historian Jenny Wormald, Willson's book was an "astonishing spectacle of a work whose every page proclaimed its author's increasing hatred for his subject". Since Willson, however, the stability of James's government in Scotland and in the early part of his English reign, as well as his relatively