Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
Descendants of James VI and I daughter, Sophia of Hanover, became the nearest Protestant relative to the English, Scottish and Irish crowns (later British crown). Under the English Act of Settlement, the succession was settled on Sophia and her issue, so her son George Ludwig ascended the throne as George I. Charles I, the second son of James VI and I was King of England, Scotland and Ireland from 27 March 1625 until his execution in 1649. The monarchy was then abolished and a republic called the Commonwealth of England, also referred to as the Cromwellian Interregnum, was declared. Charles's son, Charles II, became king after