Berkeley Hundred and 17 days before the Pilgrims arrived aboard the "Mayflower" at Plymouth, Massachusetts to establish their Thanksgiving Day in 1621. On March 22, 1622, Opchanacanough, head of the Powhatan Confederacy, began the Second Anglo-Powhatan War with a coordinated series of attacks against English settlements along the James River, known in English histories as the Indian massacre of 1622. Nine colonists were killed at Berkeley. The assault took a heavier toll elsewhere, killing about a third of all the colonists, and virtually wiping out Wolstenholme Towne on Martin's Hundred and Sir Thomas Dale's progressive development and new college at Henricus. Jamestown
Railways in Plymouth Plympton on 3 March 1959, and the Tavistock line on 31 December 1962. The old LSWR line through Devonport was closed on 7 September with remaining trains to Gunnislake running over the CR route to St Budeaux where they used the wartime connection to rejoin the old PDSWJR route. The remaining suburban services to Saltash, which had been reduced after 1961 following the opening of the Tamar Bridge for the A38 road, were withdrawn in 1972. Plymouth railway station is an important station on the Exeter to Plymouth line. Great Western Railway trains from London Paddington station either terminate here