Heart Motu Cordis" (1628) by the English physician William Harvey. Harvey's book completely describes the systemic circulation and the mechanical force of the heart, leading to an overhaul of the Galenic doctrines. Otto Frank (1865–1944) was a German physiologist; among his many published works are detailed studies of this important heart relationship. Ernest Starling (1866–1927) was an important English physiologist who also studied the heart. Although they worked largely independently, their combined efforts and similar conclusions have been recognized in the name "Frank–Starling mechanism". Although Purkinje fibers and the bundle of His were discovered as early as the 19th century, their
Personal relationships of James VI and I Castle as a guest but then kept him as prisoner for ten months. The Lord Enterprisers forced him to banish Lennox. The duke journeyed back to France and kept a secret correspondence with James. Lennox in these letters says he gave up his family "to dedicate myself entirely to you"; he prayed to die for James to prove "the faithfulness which is engraved within my heart, which will last forever." The former duke wrote "Whatever might happen to me, I shall always be your faithful servant... you are alone in this world whom my heart is resolved to serve. And