Fort Pitt Museum Pitt, after William Pitt the Elder. As a result, in 1763 local Delawares and Shawnees took part in Pontiac's Rebellion, an effort to drive the British out of their territory. The Indians' siege of Fort Pitt began on June 22, 1763, but the fort was too strong to be taken by force. In negotiations during the siege, the commander of Fort Pitt gave two Delaware emissaries blankets that had been exposed to smallpox, in hopes of infecting the surrounding Indians and ending the siege. The effectiveness of this attempt is unclear. Outbreaks of smallpox had plagued Native Americans for years
Siege of Fort Loudoun and continued to attack frontier settlements into 1760. In February 1760, they attacked Fort Prince George in an attempt to rescue their hostages. The fort's commander was killed. The garrison, in panicked retaliation, massacred all of the hostages. And two days later the fort fired artillery into the town of Keowee. The Cherokee now attacked Fort Ninety Six, but it withstood the siege. However, settlements and lesser posts in the South Carolina backcountry quickly fell to Cherokee raids. The Cherokee were led by Standing Turkey as Principal Chief, Oconostota ("Aganstata") of Chota, Attakullakulla ("Atagulgalu") of Tanasi, Ostenaco of Tomotley, Wauhatchie