Cheers Cheers Cheers is an American sitcom that ran on NBC from September 30, 1982, to May 20, 1993, with a total of 275 half-hour episodes for eleven seasons. The show was produced by Charles/Burrows/Charles Productions in association with Paramount Network Television. The show was created by the team of James Burrows, Glen Charles, and Les Charles. The show is set in a bar named Cheers in Boston, Massachusetts, where a group of locals meet to drink, relax, and socialize. The show's main theme song, co-written and performed by Gary Portnoy, lent its refrain "Where Everybody Knows Your Name" as the
Daniel A. Portnoy secreted by "L. monocytogenes" through multidrug resistance efflux transporters. Dr. Portnoy and Dr. Russell Vance identified that STING was the host receptor of cyclic-di-nucleotides (CDNs) that leads to the production of type I interferon and other co-regulated genes. Modified CDNs are now being evaluated for clinical application as adjuvants and for cancer immunotherapy. Dr. Portnoy has been awarded a number of honors over the course of his career including the Eli Lilly and Company Research Award in Microbiology & Immunology, NIH Merit Award, Fellow of the American Academy of Microbiology, Senior Scholar Award in Global Infectious Diseases from the Ellison