Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
World Malaria Day group Malaria No More. Other former U.S. Presidents are involved in anti-malaria efforts. Former President Bill Clinton's Clinton Foundation includes an anti-malaria component that, according to director Inder Singh has distributed anti-malaria drugs to millions in Africa and Asia. Many prominent companies, organizations, and celebrities have declared initiatives to join the fight against malaria to mark this day. These include a $3 million "challenge grant" announced by ExxonMobil to match donations dollar by dollar to Malaria No More, as part of the "Idol Gives Back" episodes of American Idol, which was aired on Malaria Awareness Day. Major League Soccer Commissioner