Tonic water and other tropical posts mixed the powder with soda and sugar, and tonic water was created. The first commercial tonic water was produced in 1858. The mixed drink gin and tonic also originated in British colonial India, when the British mixed their medicinal quinine tonic with gin. Since 2010, at least four tonic syrups have been available in the US. Consumers add carbonated water to the syrup to make tonic water, allowing drinkers to adjust the flavor intensity. Medicinal tonic water originally contained only carbonated water and a large amount of quinine. However, most tonic water today contains less quinine
Clausena anisata half maximal effective concentration (EC50) value was 74 μg/mL. The authors concluded that these results encourage further investigation of the use of this plant as complementary treatment options for ascariasis. This species is used in treating an uncommonly wide range of ailments and conditions. Decoctions of the leaves or roots are taken for gastro-intestinal disorders, fever, pneumonia, headache, hypotension, sore throat and sinusitis, venereal diseases, as an aphrodisiac and anthelmintic, as a tonic for pregnant women, and as a tonic for infants to prevent rickets and to control convulsions. Root decoctions and infusions are also taken for whooping cough, malaria,