Calcium-induced calcium release Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g. in the insulin-secreting pancreatic beta cells and many
Society for Scientific Exploration Society for Scientific Exploration The Society for Scientific Exploration, or SSE, is a group committed to studying fringe science. The opinions of the organization in regard to what are the proper limits of scientific exploration are often at odds with those of mainstream science. Critics argue that the SSE is devoted to disreputable ideas far outside the scientific mainstream. The Society was founded in 1982. Its first meeting took place at the University of Maryland, College Park in 1982. Of the SSE and its journal, journalist Michael D.. Lemonick writes, "Pretty much anything that might have shown up on The