Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Foreign relations of China threat from both domestic and international sources. Social unrest and serious revolts became more common while the regular army had decayed into an ineffective force. Chinese leaders increasingly feared the impact of Western ideas. After 1724 Christian propaganda was prohibited, and after 1757 international trade was confined to the port of Canton under the strictly limited Canton System. European commercial interests sought to end the trading barriers, but China fended off repeated efforts by Britain to reform the trading system. Increasing sales of Indian opium to China by British traders led to the First Opium War (1839–1842). The superiority of