Copper for treatment of Wilson's disease have been investigated for use in cancer therapy. Copper is an essential trace element in plants and animals, but not all microorganisms. The human body contains copper at a level of about 1.4 to 2.1 mg per kg of body mass. Copper is absorbed in the gut, then transported to the liver bound to albumin. After processing in the liver, copper is distributed to other tissues in a second phase, which involves the protein ceruloplasmin, carrying the majority of copper in blood. Ceruloplasmin also carries the copper that is excreted in milk, and is particularly
Copper(II) sulfate the ingestion of copper sulfate. However, if copper sulfate is retained in the stomach, the symptoms can be severe. After 1–12 grams of copper sulfate are swallowed, such poisoning signs may occur as a metallic taste in the mouth, burning pain in the chest, nausea, diarrhea, vomiting, headache, discontinued urination, which leads to yellowing of the skin. In cases of copper sulfate poisoning, injury to the brain, stomach, liver, or kidneys may also occur. Copper sulfate is highly soluble in water and therefore is easily distributed in the aquatic environments. Too much copper in water damage marine and freshwater organisms