Ernest Lawrence a scrap of a paper napkin. While sitting in the library one evening in 1929, Lawrence glanced over a journal article by Rolf Widerøe, and was intrigued by one of the diagrams. This depicted a device that produced high-energy particles by means of a succession of small "pushes". The device depicted was laid out in a straight line using increasingly longer electrodes. At the time, physicists were beginning to explore the atomic nucleus. In 1919, the New Zealand physicist Ernest Rutherford had fired alpha particles into nitrogen and had succeeded in knocking protons out of some of the nuclei. But
Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor alpha (PPAR-alpha), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein that in humans is encoded by the "PPARA" gene. Together with peroxisome proliferator-activated receptor delta and peroxisome proliferator-activated receptor gamma, PPAR-alpha is part of the subfamily of peroxisome proliferator-activated receptors. It was the first member of the PPAR family to be cloned in 1990 by Stephen Green and has been identified as the nuclear receptor for a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. PPAR-alpha is a transcription factor and a