Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
Tonic vibration reflex muscle to contract. The effects of sustained vibratory stimulation on muscle contraction, posture and kinesthetic perceptions are much more complex than merely contraction of the muscle being vibrated. Russian scientists Victor Gurfinkel, Mikhail Lebedev, Andrew Polyakov and Yuri Levick used vibratory stimulation to study human posture control and spectral characteristics of electromyographic (EMG) activity. Tonic vibration reflex Tonic vibration reflex is a sustained contraction of a muscle subjected to vibration. This reflex is caused by vibratory activation of muscle spindles — muscle receptors sensitive to stretch. Tonic vibration reflex is evoked by placing a vibrator — which in this case