Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
Gin and tonic an "Evans". Although the origins of the use of lemons are unknown, their use dates back at least as far as the late 1930s. In addition lemons are often more readily available, and cheaper to purchase, than limes. The use of lemon or lime is a debated issue and while leading brands, such as Gordon's, Tanqueray and Bombay Sapphire recommend the use of lime, the founder of Fevertree Tonic Water prefers lemon. Some people garnish a Beefeater-based gin and tonic with a slice of orange, to complement the Seville oranges Beefeater uses in its botanicals. A gin and tonic served