Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
Mozart and smallpox both children's illness to contend with, the Mozarts spent a total of four months away from Vienna. They eventually returned there and were received in the Imperial court on 19 January, 1768. The Empress, who had by now lost three children to smallpox, conversed with Frau Mozart about the disease. The remainder of the trip was not especially successful. Leopold apparently misinterpreted a chance remark of the Emperor as a firm invitation for Wolfgang to compose an opera; this resulted in Wolfgang writing "La finta semplice". However, the opera went unperformed in Vienna; the singers and musicians did not like