History of malaria and brain which are the most constant post-mortem indications of chronic malaria infection. He related the prevalence of malaria in swampy areas to the presence of flies and recommended swamp drainage to prevent it. In the nineteenth century, the first drugs were developed to treat malaria and parasites were first identified as its source. French chemist Pierre Joseph Pelletier and French pharmacist Joseph Bienaimé Caventou separated in 1820 the alkaloids cinchonine and quinine from powdered fever tree bark, allowing for the creation of standardized doses of the active ingredients. Prior to 1820, the bark was simply dried, ground to a
History of malaria and make them more susceptible to other diseases. Spanish missionaries found that fever was treated by Amerindians near Loxa (Peru) with powder from Peruvian bark (later established to be from any of several trees of genus "Cinchona"). It was used by the Quechua Indians of Peru to reduce the shaking effects caused by severe chills. Jesuit Brother Agostino Salumbrino (1561–1642), who lived in Lima and was an apothecary by training, observed the Quechua using the bark of the cinchona tree for that purpose. While its effect in treating malaria (and hence malaria-induced shivering) was unrelated to its effect in controlling