Copper-64 specific activity (the number of decays per second per amount of substance) and low yield through the Cu(n,γ)Cu reaction. At the University of Missouri Research Reactor Center (MURR) Cu was produced using high-energy neutrons via the Zn(n,p)Cu reaction in high specific activity but low yield. Using a biomedical cyclotron the Ni(p,n)Cu nuclear reaction can produce large quantities of the nuclide with high specific activity. Wilson’s disease is a rare condition in which copper is retained excessively in the body. Toxic levels of copper can lead to organ failure and premature death. Cu is used to study whole body retention of
Alcohol-related brain damage and NMDA suppression causes alcohol induced neurotoxicity and kindling, or worsening of alcohol withdrawal symptoms with each subsequent withdrawal period. This may cause CNS depression leading to acute tolerance to these withdrawal effects. This tolerance is followed by a damaging rebound effect during withdrawal. This rebound causes hyperexcitability of neurotransmission systems. If this hyperexcitability state occurs multiple times, kindling and neurotoxicity can occur leading to increased alcohol-related brain damage. Damaging excitotoxicity may also occur as a result of repeated withdrawals. Similar to people who have gone through multiple detoxifications, binge drinkers show a higher rate of emotional disturbance due to