Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Western imperialism in Asia China vulnerable to Western, Meiji period Japanese, and Russian imperialism. In 1839, China found itself fighting the First Opium War with Britain. China was defeated, and in 1842, signed the provisions of the Treaty of Nanjing which were first of the unequal treaties signed during the Qing Dynasty. Hong Kong Island was ceded to Britain, and certain ports, including Shanghai and Guangzhou, were opened to British trade and residence. In 1856, the Second Opium War broke out. The Chinese were again defeated, and now forced to the terms of the 1858 Treaty of Tientsin. The treaty opened new ports to