Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Protestant missions in China countries. They entered China at a time of growing power by the British East India Company, but were initially restricted from living and traveling in China except for the limited area of the Thirteen Factories in Canton, now known as Guangzhou, and Macau. In the 1842 treaty ending the First Opium War missionaries were granted the right to live and work in five coastal cities. In 1860, the treaties ending the Second Opium War with the French and British opened up the entire country to missionary activity. Protestant missionary activity exploded during the next few decades. From 50 missionaries in