History of malaria and brain which are the most constant post-mortem indications of chronic malaria infection. He related the prevalence of malaria in swampy areas to the presence of flies and recommended swamp drainage to prevent it. In the nineteenth century, the first drugs were developed to treat malaria and parasites were first identified as its source. French chemist Pierre Joseph Pelletier and French pharmacist Joseph Bienaimé Caventou separated in 1820 the alkaloids cinchonine and quinine from powdered fever tree bark, allowing for the creation of standardized doses of the active ingredients. Prior to 1820, the bark was simply dried, ground to a
Tonic (music) atonal context, often acting as axis or line of symmetry in an interval cycle. Pitch centricity was coined by Arthur Berger in his "Problems of Pitch Organization in Stravinsky". The tonic diatonic function includes 4 separate activities or roles as the principal goal tone, initiating event, generator of other tones, and the stable center neutralizing the tension between dominant and subdominant Tonic (music) In music, the tonic is the first scale degree of a diatonic scale (the first note of a scale) and the tonal center or final resolution tone that is commonly used in the final cadence in tonal