Tonic water and other tropical posts mixed the powder with soda and sugar, and tonic water was created. The first commercial tonic water was produced in 1858. The mixed drink gin and tonic also originated in British colonial India, when the British mixed their medicinal quinine tonic with gin. Since 2010, at least four tonic syrups have been available in the US. Consumers add carbonated water to the syrup to make tonic water, allowing drinkers to adjust the flavor intensity. Medicinal tonic water originally contained only carbonated water and a large amount of quinine. However, most tonic water today contains less quinine
Malaria furthest influence reaches into some temperate zones that have extreme seasonal changes. The disease has been associated with major negative economic effects on regions where it is widespread. During the late 19th and early 20th centuries, it was a major factor in the slow economic development of the American southern states. A comparison of average per capita GDP in 1995, adjusted for parity of purchasing power, between countries with malaria and countries without malaria gives a fivefold difference ($1,526 USD versus $8,268 USD). In the period 1965 to 1990, countries where malaria was common had an average per capita GDP