Calcium-induced calcium release of CICR across the cell causes the significant increase in cytosolic Ca that is important in activating muscle contraction. Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely
A Scientific Support for Darwinism case, as well as announce the results in a press release. The petition was not completed sufficiently early to submit it as part of an "amicus curae" brief for the Dover case. However, if the case was to go to the US Supreme Court, the petition could have been submitted as an "amicus" brief at that time. R. Joe Brandon emphasized that this "Four Day Petition" did not mean that scientific issues are settled by majority vote. What Brandon maintains is that this is an indication of the level of scientific consensus that accepts evolution as a viable established scientific