Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Tonic Trouble The only remnants of that game were found to be pieces of concept art created by Ubi Soft artist Yann Jouette. "Tonic Trouble" was met with mixed reception upon release, according to review aggregator GameRankings. "Tonic Trouble" sold 1.1 million copies as of 2001. "Electronic Gaming Monthly" thought that, in terms of level design, "Tonic Trouble" was "a tightly developed platformer"; the control scheme was similarly praised. "Game Informer" wrote that the "wide variety" of gameplay and "solid" controls would be enjoyable to platformer fans. "GamePro" commended the musical score and sound effects, noting the puzzles as what kept the