Calcium-induced calcium release Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g. in the insulin-secreting pancreatic beta cells and many
Gender symbol two standard sex symbols are the Mars symbol ♂ (often considered to represent a shield and spear) for male and Venus symbol ♀ (often considered to represent a bronze mirror with a handle) for female, derived from astrological symbols, denoting the classical planets Mars and Venus, respectively. They were first used to denote the effective sex of plants (i.e. sex of individual in a given crossbreed, since most plants are hermaphroditic) by Carl Linnaeus in 1751. They are still used in scientific publications to indicate the sex of an individual, for example of a patient. Pedigree charts published in scientific