Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Anarchism in Singapore much of which came to Singapore due to political or economic reasons – such as migrants leaving southern China to escape economic hardships, and refugees from the First Opium War (1839–1842) and Second Opium War (1856–1860) – has historically been a driving force behind radical political ideologies in the country. During the anti-Manchu upheavals of the late 19th and early 20th century in China, Chinese anarchists played an influential part opposing and eventually overthrowing the Qing Dynasty. Singapore played an important role in this process, serving as a center for Chinese revolutionary activity. In 1906 it became the headquarters of