Calcium-induced calcium release of CICR across the cell causes the significant increase in cytosolic Ca that is important in activating muscle contraction. Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely
Coral calcium Coral calcium Coral calcium is a salt of calcium derived from fossilized coral reefs (primarily from limestone and coastal deposits). It has been promoted as an alternative, but unsubstantiated, treatment or cure for a number of health conditions. Coral calcium has been promoted as an alternative treatment or cure for a number of health conditions, often as part of an alkaline diet, by Robert Barefoot and others; Barefoot coauthored a book called "The Calcium Factor," and marketed coral calcium supplements with infomercials. According to a "Time" magazine article about Barefoot by Leon Jaroff, "The monthly cost of the recommended dose