Calcium-induced calcium release Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g. in the insulin-secreting pancreatic beta cells and many
Calcium carbonate Calcium carbonate shares the typical properties of other carbonates. Notably, Calcium carbonate will react with water that is saturated with carbon dioxide to form the soluble calcium bicarbonate. This reaction is important in the erosion of carbonate rock, forming caverns, and leads to hard water in many regions. An unusual form of calcium carbonate is the hexahydrate, ikaite, CaCO·6HO. Ikaite is stable only below 8 °C. The vast majority of calcium carbonate used in industry is extracted by mining or quarrying. Pure calcium carbonate (e.g. for food or pharmaceutical use), can be produced from a pure quarried source (usually marble).