Calcium-induced calcium release of CICR across the cell causes the significant increase in cytosolic Ca that is important in activating muscle contraction. Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely
Calcium lactate Calcium lactate Calcium lactate is a white crystalline salt with formula , consisting of two lactate anions (CHOH) for each calcium cation . It forms several hydrates, the most common being the pentahydrate ·5. Calcium lactate is used in medicine, mainly to treat calcium deficiencies; and as a food additive with E number of E327. Some cheese crystals consist of calcium lactate. The lactate ion is chiral, with two enantiomers, D (−,"R") and L (+,"S"). The L isomer is the one normally synthesized and metabolized by living organisms, but some bacteria can produce the D form or convert the L