Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
Smallpox demon parts of India, China, Africa and Latin America, sacrifices were made to appease the gods of smallpox. In medieval Europe, prayer and pious living were recommended as one way to guard against sickness. Many Japanese textbooks on dermatology stated that red light was able to weaken the symptoms of smallpox. This was common in China, India, Turkey and Georgia. In western Africa, the Yoruba god of smallpox, Sopona, was associated with the color red. The red treatment was given scientific authority by Finsen, who claimed that the treatment of smallpox patients with red light reduced the severity of scarring, and