Smallpox 1718. In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. In 1796, Edward Jenner, a doctor in Berkeley, Gloucestershire, rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine, from the root word "vacca", which is Latin for cow. The procedure was much safer than variolation, and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox was soon practiced all over the world. During the
Early clashes in the Rhine campaign of 1796 systematically divested of old men who might have tempered the rash impulses of teenagers and young adults. It had already made itself odious, by rumor and action, throughout France. Furthermore, it was an army entirely dependent upon the countryside for its material support. After April 1796, pay was made in metallic value, but pay was still in arrears. Throughout the spring and early summer, the unpaid French army was in almost constant mutiny: in May 1796, in the border town of Zweibrücken, the 74th Demi-brigade revolted. In June, the 17th Demi-brigade was insubordinate (frequently) and in the 84th Demi-brigade, two