Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
History of smallpox in Mexico that started in Valley of Mexico, principally affecting children. More people recovered than died. In Mexico City, of 5400 cases admitted to the hospital, 4431 recovered and 1,331 died. This epidemic coincided with the rise of prices of corn and a typhus epidemic, which caused a slight demographic decrease in central Mexico. Another smallpox epidemic came into Mexico from Guatemala in 1794. Oaxaca and Chiapas were the first places affected by smallpox because of proximity. The epidemic traveled from Oaxaca to Puebla, and then spread to Mexico City and Veracruz by 1797. By 1798, the epidemic had reached Saltillo and