Simon & Marcy "everyone [working on the series] was pitching in to make this one special". The episode features the voice of Ava Acres, who portrays the young version of Marceline. Acres had previously appeared in the third season episode "Memory of a Memory". As mentioned above, the episode makes notable use of the 1982 song "Where Everybody Knows Your Name" by Gary Portnoy—better known as the theme to the sitcom "Cheers". According to Sugar's father, Rob, on his official YouTube channel, the use of the song started merely as a placeholder. However, as the episode developed, Sugar decided to keep it in
Daniel A. Portnoy Pennsylvania, where he collaborated with Dr. Lewis Tilney in the Biology Department and made the observation that "L. monocytogenes" spreads from one cell to another by exploiting a host cell system of actin polymerization. His lab also defined the role of the listerial hemolysin in mediating dissolution of phagosomes. In collaboration with Dr. Philip Youngman, he showed that expression of the "L. monocytogenes" hemolysin by "Bacillus subtilis" led to its growth inside of host cells. Dr. Portnoy collaborated with Dr. Yvonne Paterson, who also arrived at Penn in 1988, on the use of "L. monocytogenes" as a recombinant vector-based vaccine