Smallpox vaccine Smallpox vaccine Smallpox vaccine, the first successful vaccine to be developed, was introduced by Edward Jenner in 1796. He followed up his observation that milkmaids who had previously caught cowpox did not later catch smallpox by showing that inoculated cowpox protected against inoculated smallpox. Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been
Practical joke victimized or humiliated. Thus most practical jokes are affectionate gestures of humour and designed to encourage laughter. However, practical jokes performed with cruelty can constitute bullying, whose intent is to harass or exclude rather than reinforce social bonds through ritual humbling. Some countries in Western culture traditionally emphasize the carrying out of practical jokes on April Fools' Day. A practical joke is "practical" because it consists of someone doing something physical, in contrast to a verbal or written joke. For example, the joker who is setting up and conducting the practical joke might hang a bucket of water above a