Calcium metabolism Calcium metabolism Calcium metabolism refers to the movements and regulation of calcium ions (Ca) "in" and "out" of various body compartments, such as the gastrointestinal tract, the blood plasma, the extracellular and intracellular fluids, and bone tissue. An important aspect of calcium metabolism is plasma calcium homeostasis, the regulation of calcium ions in the blood plasma within narrow limits. In this process, bone tissue acts as a calcium storage center for deposits and withdrawals as needed by the blood, via continual bone remodeling. Derangement of this mechanism leads to hypercalcemia or hypocalcemia, both of which can have consequences for health.
N-type calcium channel when binding to the receptors, can inhibit the release of the pro-nociceptive neurotransmitters and neuromodulators that come from the central nerve terminals of the afferent neurons. This inhibition is what ultimately can stop the transmission of pain to the person from damaged cells. Ziconotide is an inorganic version of the ɷɷ-conotoxin, MVIIA. This medicine is able to inhibit the release of pro-nociceptive receptors, which will then block the transmission of pain. N-type calcium channel N-type calcium channels are voltage gated calcium channels that are distributed throughout the entire body. These channels are high voltage activated channels composed of alpha-1B subunits.