Copper-64 specific activity (the number of decays per second per amount of substance) and low yield through the Cu(n,γ)Cu reaction. At the University of Missouri Research Reactor Center (MURR) Cu was produced using high-energy neutrons via the Zn(n,p)Cu reaction in high specific activity but low yield. Using a biomedical cyclotron the Ni(p,n)Cu nuclear reaction can produce large quantities of the nuclide with high specific activity. Wilson’s disease is a rare condition in which copper is retained excessively in the body. Toxic levels of copper can lead to organ failure and premature death. Cu is used to study whole body retention of
Mechanism of anoxic depolarization in the brain infarction, the release of glutamate and aspartate into the extracellular space causes an uncontrollable intracellular mobilization of Ca, mainly through the NMDA receptors. This is a critical stage in the development of neuronal damage, because it is the Ca overload that gives rise to several downstream cascades of events that lead to necrotic neuronal death, or to apoptosis, including free radical and nitric oxide productions that cause damage to the membrane. Another cytotoxic event that follows anoxic depolarization is lactate accumulation and acidosis as a result of glycolysis, which causes damage to the mitochondria. Ischemic insult also causes blood-brain barrier