Tonic water and is used mostly for its flavor. As a result of the lower quinine content, it is less bitter, and is also usually sweetened, often with high-fructose corn syrup or sugar. Some manufacturers also produce diet (or slimline) tonic water, which may contain artificial sweeteners such as aspartame. Traditional-style tonic water with little more than quinine and carbonated water is less common but may be preferred by those who desire the bitter flavor. In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm (83 mg per liter if calculated
History of malaria spleen in Pedanius Dioscorides's "De Materia Medica" have been suggested to have been a response to chronic malaria in the Roman empire. Some so-called "vampire burials" in late antiquity may have been performed in response to malaria epidemics. For example, some children who died of malaria were buried in the necropolis at Lugnano in Teverina using rituals meant to prevent them from returning from the dead. Modern scholars hypothesize that communities feared that the dead would return and spread disease. In 835, the celebration of Hallowmas (All Saints Day) was moved from May to November at the behest of Pope