Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Tonic (Tonic album) Tonic (Tonic album) Tonic is the self-titled fourth studio album by modern rock band Tonic. The project was originally announced in 2008, with writing and recording carrying through summer and fall of 2009. Recorded primarily at Conway Studios in Hollywood, California, the album was co-produced by Tonic and Nathaniel Kunkel. Critical reception to "Tonic" was generally positive. The album was released on May 4, 2010 in North America, and spent one week on the "Billboard" 200 album chart, where it ranked 150. The band subsequently embarked on a tour to coincide with this album's release. Band member Jeff Russo originally