Adrenaline of epinephrine can be seen in autonomic neuropathy or following adrenalectomy. Failure of the adrenal cortex, as with Addisons disease, can suppress epinephrine secretion as the activity of the synthesing enzyme, phenylethanolamine-"N"-methyltransferase, depends on the high concentration of cortisol that drains from the cortex to the medulla. In 1901, Jokichi Takamine patented a purified extract from the adrenal glands, and called it "adrenalin" (from the Latin for "on top of the kidneys" ("ad" and "renal"), which was trademarked by Parke, Davis & Co in the US. The British Approved Name and European Pharmacopoeia term for this drug is hence "adrenaline".
Grading of the tumors of the central nervous system Typing of Tumours of the Central Nervous System", whose first edition dates back to 1979, the second to 1993 and last one to 2007. The WHO grade has four categories of tumors: From the histological point of view the WHO system is based on the same criteria as the St Anne-Mayo system. In the following table the various grading systems are compared (the IDC-O scale is not comprised because it is not considered a real grading system): Grading of the tumors of the central nervous system The concept of grading of the tumors of the central nervous system, agreeing for