Tonic water and is used mostly for its flavor. As a result of the lower quinine content, it is less bitter, and is also usually sweetened, often with high-fructose corn syrup or sugar. Some manufacturers also produce diet (or slimline) tonic water, which may contain artificial sweeteners such as aspartame. Traditional-style tonic water with little more than quinine and carbonated water is less common but may be preferred by those who desire the bitter flavor. In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm (83 mg per liter if calculated
History of malaria of drug-resistant and drug-sensitive malaria, especially cerebral malaria. These drugs are characterized by fast action, high efficacy and good tolerance. They kill the asexual forms of "P. berghei" and "P. cynomolgi" and have transmission-blocking activity. In 1985, Zhou Yiqing and his team combined artemether and lumefantrine into a single tablet, which was registered as a medicine in China in 1992. Later it became known as “Coartem”. Artemisinin combination treatments (ACTs) are now widely used to treat uncomplicated "falciparum" malaria, but access to ACTs is still limited in most malaria-endemic countries and only a minority of the patients who need artemisinin-based