Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
Practical joke victimized or humiliated. Thus most practical jokes are affectionate gestures of humour and designed to encourage laughter. However, practical jokes performed with cruelty can constitute bullying, whose intent is to harass or exclude rather than reinforce social bonds through ritual humbling. Some countries in Western culture traditionally emphasize the carrying out of practical jokes on April Fools' Day. A practical joke is "practical" because it consists of someone doing something physical, in contrast to a verbal or written joke. For example, the joker who is setting up and conducting the practical joke might hang a bucket of water above a