Simon & Marcy "everyone [working on the series] was pitching in to make this one special". The episode features the voice of Ava Acres, who portrays the young version of Marceline. Acres had previously appeared in the third season episode "Memory of a Memory". As mentioned above, the episode makes notable use of the 1982 song "Where Everybody Knows Your Name" by Gary Portnoy—better known as the theme to the sitcom "Cheers". According to Sugar's father, Rob, on his official YouTube channel, the use of the song started merely as a placeholder. However, as the episode developed, Sugar decided to keep it in
Daniel A. Portnoy secreted by "L. monocytogenes" through multidrug resistance efflux transporters. Dr. Portnoy and Dr. Russell Vance identified that STING was the host receptor of cyclic-di-nucleotides (CDNs) that leads to the production of type I interferon and other co-regulated genes. Modified CDNs are now being evaluated for clinical application as adjuvants and for cancer immunotherapy. Dr. Portnoy has been awarded a number of honors over the course of his career including the Eli Lilly and Company Research Award in Microbiology & Immunology, NIH Merit Award, Fellow of the American Academy of Microbiology, Senior Scholar Award in Global Infectious Diseases from the Ellison