Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Tonic 23 normally fitted with a small outboard motor for docking and maneuvering or optionally an inboard motor could be installed. The design has a hull speed of and the fresh water tank has a capacity of Similar sailboats Tonic 23 The Tonic 23 is a French trailerable sailboat, that was designed by Philippe Harlé as a coastal cruising sailboat and first built in 1985. The design was built by Jeanneau in France from 1985 until 1992, but it is now out of production. During its production run about 750 boats were completed. The Tonic 23 is a small recreational keelboat, built