Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Tonic (Tonic album) #50 on the Billboard Rock album chart, and #25 on the Billboard Independent Albums chart. The album did not chart on either one of those listings after its debut week though. Initial critical reception to the album was positive. Allmusic critic Mark Demming rated the album three out of five stars, saying, "Thankfully, Tonic doesn't sound like the work of a band struggling to re-create their past success, and instead finds them confidently embracing their signature sound and doing what they do with a sure hand and genuine inspiration...Tonic is less a comeback than an enthusiastic return to form, and