Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Malaria Day in the Americas Malaria Day in the Americas Malaria Day in the Americas is commemorated annually on November 6 to promote awareness, recognize past and current efforts to prevent and control malaria in the region of the Americas, build commitment, and to mobilize action to advance malaria goals and targets as the region works towards elimination. Awareness of this disease is very important in the region of the Americas, where an estimated 120 million people in 21 endemic countries are at risk of malaria. In 2012, there were 469,000 confirmed malaria cases in the region with 108 deaths. Nonetheless, declining incidence of disease