Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
Early clashes in the Rhine campaign of 1796 systematically divested of old men who might have tempered the rash impulses of teenagers and young adults. It had already made itself odious, by rumor and action, throughout France. Furthermore, it was an army entirely dependent upon the countryside for its material support. After April 1796, pay was made in metallic value, but pay was still in arrears. Throughout the spring and early summer, the unpaid French army was in almost constant mutiny: in May 1796, in the border town of Zweibrücken, the 74th Demi-brigade revolted. In June, the 17th Demi-brigade was insubordinate (frequently) and in the 84th Demi-brigade, two