Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Political theology in China In the 18th century, the Chinese Rites controversy had raised tension between the Vatican and Qing dynasty's Emperors. Emperor Yongzheng was formally against Christian converts among Manchu people and banned the mission again. After the First Opium War (1839–1842), with the aid of several unequal treaties, Christian missionaries were allowed to evangelize in China and continue to import the Western civilization to China. Due to an impression that missionaries were allies with foreign colonial governments, many Chinese became hostile to Christianity. This further influenced the relationship between Christianity and politics. Many anti-missionary riots ("Jiao'an"), the Boxer Rebellion, and the anti-Christian