Smallpox vaccine Smallpox vaccine Smallpox vaccine, the first successful vaccine to be developed, was introduced by Edward Jenner in 1796. He followed up his observation that milkmaids who had previously caught cowpox did not later catch smallpox by showing that inoculated cowpox protected against inoculated smallpox. Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been
History of smallpox in Mexico that started in Valley of Mexico, principally affecting children. More people recovered than died. In Mexico City, of 5400 cases admitted to the hospital, 4431 recovered and 1,331 died. This epidemic coincided with the rise of prices of corn and a typhus epidemic, which caused a slight demographic decrease in central Mexico. Another smallpox epidemic came into Mexico from Guatemala in 1794. Oaxaca and Chiapas were the first places affected by smallpox because of proximity. The epidemic traveled from Oaxaca to Puebla, and then spread to Mexico City and Veracruz by 1797. By 1798, the epidemic had reached Saltillo and