Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
Rhine Campaign of 1796 Germany. By the spring of 1796, Jourdan and Moreau each had 70,000 men while Bonaparte's army numbered 63,000, including reserves and garrisons. François Christophe de Kellermann also counted 20,000 troops in the Army of the Alps holding the area between Moreau and Bonaparte on the western side of modern Switzerland; there was a smaller army in southern France that played no role in the Rhine Campaign. According to plan, Kléber made the first move, advancing south from Düsseldorf against Württemberg's wing of the Army of the Lower Rhine. On 1 June 1796, a division of Kléber's troops led by François