Freckle regular use of sunblock can inhibit their development. Liver spots (also known as sun spots and lentigines) look like large freckles, but they form after years of exposure to the sun. Liver spots are more common in older people. Freckle Freckles are clusters of concentrated melaninized cells which are most easily visible on people with a fair complexion. Freckles do not have an increased number of the melanin-producing cells, or melanocytes, but instead have melanocytes that overproduce melanin granules (melanosomes) changing the coloration of the outer skin cells (keratinocytes). As such, freckles are different from lentigines and moles, which are
The Adventure of the Yellow Face loving response is reported approvingly by Watson. This story, however, should be set alongside Doyle's stereotyped caricature of a thuggish black boxer, in "The Adventure of the Three Gables" (1926). "The Yellow Face" was dramatised for BBC Radio 4 in 1992 as part of Bert Coules' complete radio adaptation of the canon, starring Clive Merrison as Holmes and Michael Williams as Watson, and featuring Helena Breck as Effie Munro. The story is also alluded to in the BBC television series "Sherlock" where a yellow smiley face is painted on the wall of Sherlock's flat. Additionally, quotes from the story are