Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Double tonic including Beck's "Puttin It Down". Double tonic patterns may be classified as beginning on the lower ("Sumer is Icumen in", "The Woods so Wild", "The Irish Washerwoman") or upper (most Scottish tunes, passamezzo antico, "Roun' de Corn, Sally", "Shallow Brown", "Mkwaze mmodzi") note and may repeat open endedly, though they are often closed through a tonic close, as in : They are also often varied through a binary scheme ending on the dominant then tonic, as in: or, A variation of this last progression is the passamezzo antico. Double tonic A double tonic is a chord progression, melodic motion, or