Science and invention in Birmingham 1054 Mk XVIs) had been built. CBAF became the largest and most successful plant of its type during the 1939–45 conflict. As the largest Spitfire factory in the UK, by producing up to 320 aircraft per month, it built over half of the approximately 20,000 aircraft of this type. 1944: Anthony Ernest Pratt takes out his first patent for a board game named 'Murder', this is later to become the world-renowned murder mystery game 'Cluedo'. 1946: Chance Brothers produce the first all-glass syringe with interchangeable barrel and plunger, thereby allowing mass sterilisation of components without the need for matching them.
Mystery fiction contribution to mystery fiction in the 1920s was the development of the juvenile mystery by Edward Stratemeyer. Stratemeyer originally developed and wrote the Hardy Boys and Nancy Drew mysteries written under the Franklin W. Dixon and Carolyn Keene pseudonyms respectively (and were later written by his daughter, Harriet Adams, and other authors). The 1920s also gave rise to one of the most popular mystery authors of all time, Agatha Christie, whose works include "Murder on the Orient Express" (1934), "Death on the Nile" (1937), and the world's best-selling mystery "And Then There Were None" (1939). The massive popularity of pulp