Calcium-induced calcium release of CICR across the cell causes the significant increase in cytosolic Ca that is important in activating muscle contraction. Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely
Answering the Question: What is Enlightenment? II of Prussia for creating these preconditions. Kant focused on religious issues, saying that "our rulers" had less interest in telling citizens what to think in regard to artistic and scientific issues. Kant answers the question in the first sentence of the essay: "Enlightenment is man's emergence from his self-incurred immaturity (Unmündigkeit)." He argues that the immaturity is self-inflicted not from a lack of understanding, but from the lack of courage to use one's reason, intellect, and wisdom without the guidance of another. He exclaims that the motto of enlightenment is "Sapere aude"! – Dare to be wise! In the