Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
Practical joke victimized or humiliated. Thus most practical jokes are affectionate gestures of humour and designed to encourage laughter. However, practical jokes performed with cruelty can constitute bullying, whose intent is to harass or exclude rather than reinforce social bonds through ritual humbling. Some countries in Western culture traditionally emphasize the carrying out of practical jokes on April Fools' Day. A practical joke is "practical" because it consists of someone doing something physical, in contrast to a verbal or written joke. For example, the joker who is setting up and conducting the practical joke might hang a bucket of water above a