Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
The Iron Tonic 19th-century-engraving style, the work comprises 14 panels of illustration and rhyming text in iambic pentameter. It tells the story of an eerie, melancholy manor whose inhabitants are either old or unwell. Wim Tigges described the book as "a compilation of hardly related couplets," in which nonsense objects "are seen to be falling unaccountably out of the sky." Tigges notes it uses a device commonly used in Gorey's writing, "the unexplained recurrence of an irrelevant object". The Iron Tonic The Iron Tonic: Or, A Winter Afternoon in Lonely Valley is a Surrealist country-house mystery—that is, a series of clues that don't