Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
History of malaria of drug-resistant and drug-sensitive malaria, especially cerebral malaria. These drugs are characterized by fast action, high efficacy and good tolerance. They kill the asexual forms of "P. berghei" and "P. cynomolgi" and have transmission-blocking activity. In 1985, Zhou Yiqing and his team combined artemether and lumefantrine into a single tablet, which was registered as a medicine in China in 1992. Later it became known as “Coartem”. Artemisinin combination treatments (ACTs) are now widely used to treat uncomplicated "falciparum" malaria, but access to ACTs is still limited in most malaria-endemic countries and only a minority of the patients who need artemisinin-based