Tonic water Tonic water Tonic water (or Indian tonic water) is a carbonated soft drink in which quinine is dissolved. Originally used as a prophylactic against malaria, tonic water usually now has a significantly lower quinine content and is consumed for its distinctive bitter flavor. It is often used in mixed drinks, particularly in gin and tonic. Quinine was added to the drink as a prophylactic against malaria, since it was originally intended for consumption in tropical areas of South Asia and Africa, where the disease is endemic. Quinine powder is so bitter that British officials stationed in early 19th century India
Human genetic resistance to malaria and loss of the Gerbich antigen and the Duffy antigen. These names refer to various proteins, enzymes, and the shape or function of red blood cells. The potent effect of genetically controlled innate resistance is reflected in the probability of survival of young children in areas where malaria is endemic. It is necessary to study innate immunity in the susceptible age group (younger than four years), because in older children and adults, the effects of innate immunity are overshadowed by those of adaptive immunity. It is also necessary to study populations in which random use of antimalarial drugs does not