Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
Campaigns of 1796 in the French Revolutionary Wars signed the Second Treaty of San Ildefonso with France on 19 August 1796, entering the war against Britain on the side of France in return for concessions in Italy. In response, Britain withdrew from Corsica in order to concentrate the Mediterranean fleet at Gibraltar against the combined threat. This article makes use of the out-of-copyright work "History of the French Revolution" by François Mignet (1824): Campaigns of 1796 in the French Revolutionary Wars The French Revolutionary Wars continued from 1795, with the French in an increasingly strong position as members of the First Coalition made separate peaces. Austria and Great