Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Tonic Trouble Stahl, Casamassina found there to be too few sound effects. Reviewing the game on PC, Vincent Lopez of "IGN" compared the game to "Rayman 2" like Casamassina, faulting "Tonic Trouble" for being too much like past platformers. The camera was subject to reproval for how it would inherently worsen the gameplay experience, adding to his dissatisfaction with the "wonky" controls. Jones derided the game's "shamelessly derivative" nature. "Nintendo Power" complained about certain areas where "hit detection" failed to give effect. Tonic Trouble Tonic Trouble is an action-adventure game developed by Ubi Soft Montreal and published by Ubi Soft. Conceptualized by