Calcium metabolism Calcium metabolism Calcium metabolism refers to the movements and regulation of calcium ions (Ca) "in" and "out" of various body compartments, such as the gastrointestinal tract, the blood plasma, the extracellular and intracellular fluids, and bone tissue. An important aspect of calcium metabolism is plasma calcium homeostasis, the regulation of calcium ions in the blood plasma within narrow limits. In this process, bone tissue acts as a calcium storage center for deposits and withdrawals as needed by the blood, via continual bone remodeling. Derangement of this mechanism leads to hypercalcemia or hypocalcemia, both of which can have consequences for health.
N-type calcium channel having a role in the transmission of nociceptive information in the body. A new drug, Ziconotide, is being tested to alter N-type channels in order to treat these conditions of chronic pain. One of the newest medicines is an analgesic drug that works through targeting N-type calcium channels specifically in order to lessen the transmission of pain. Peptide ɷɷ-conotoxins are what bind to the N-type calcium channels in order to block ion permeation, which then blocks the influx of calcium and the transmission of the nociceptive responses. Neurons located in the posterior horn of the spinal cord experience ɷɷ-conotoxins that,