Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
2017 China–India border standoff with weapons and two bulldozers, entered Doklam to stop the Chinese troops from constructing the road. On 28 August, both India and China announced that they had withdrawn all their troops from the face-off site in Doklam. Doklam is an area disputed between China and Bhutan located near their tri-junction with India. Unlike China and Bhutan, India does not claim Doklam but supports Bhutan's claim. China's claim on Doklam is based on the 1890 Convention of Calcutta between China and Britain, which states in Article I: The boundary of Sikkim and Tibet shall be the crest of the mountain range