Hepatitis In hemochromatosis, excess amounts of iron accumulate in multiple body sites, including the liver, which can lead to cirrhosis. In Wilson's disease, excess amounts of copper accumulate in the liver and brain, causing cirrhosis and dementia. When the liver is involved, alpha-1-antitrypsin deficiency and Wilson's disease tend to present as hepatitis in the neonatal period or in childhood. Hemochromatosis typically presents in adulthood, with the onset of clinical disease usually after age 50. Ischemic hepatitis (also known as shock liver) results from reduced blood flow to the liver as in shock, heart failure, or vascular insufficiency. The condition is most
Alcohol-related brain damage these damaging effects. A nutritional deficiency in thiamine can worsen alcohol-related brain damage. There is a genetic component to thiamine deficiency that causes intestinal malabsorption. More frequently however, thiamine deficiency is caused by excessive alcohol consumption. This leads to Wernicke’s encephalopathy and Korsakoff’s Syndrome which frequently occur simultaneously, known as Wernicke-Korsakoff syndrome. Lesions, or brain abnormalities, are typically located in the diencephalon which result in anterograde and retrograde amnesia, or memory loss. Neuroimaging is used to study the effect that alcohol has on the brain. The two main imaging methods are hemo-dynamic and electromagnetic. These techniques have allowed for the