Copper-64 specific activity (the number of decays per second per amount of substance) and low yield through the Cu(n,γ)Cu reaction. At the University of Missouri Research Reactor Center (MURR) Cu was produced using high-energy neutrons via the Zn(n,p)Cu reaction in high specific activity but low yield. Using a biomedical cyclotron the Ni(p,n)Cu nuclear reaction can produce large quantities of the nuclide with high specific activity. Wilson’s disease is a rare condition in which copper is retained excessively in the body. Toxic levels of copper can lead to organ failure and premature death. Cu is used to study whole body retention of
Alcohol-related brain damage persistent changes in neuroimmune signalling from binge drinking. The cerebral atrophy that alcoholics often present with is due to alcohol induced neurotoxicity. Evidence of neurodegeneration can be supported by an increased microglia density and expression of proinflammatory cytokines in the brain. Animal studies find that heavy and regular binge drinking causes neurodegeneration in corticolimbic brain regions areas which are involved in learning and spatial memory. The corticolimbic brain regions affected include the olfactory bulb, piriform cortex, perirhinal cortex, entorhinal cortex, and the hippocampal dentate gyrus. It was found that a heavy 2-day drinking binge caused extensive neurodegeneration in the entorhinal