Calcium-induced calcium release of CICR across the cell causes the significant increase in cytosolic Ca that is important in activating muscle contraction. Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely
Degree symbol the degree symbol (e.g., 10 °C). However, in many works with professional typesetting, including scientific works published by the University of Chicago Press or Oxford University Press, the degree symbol is printed with no spaces between the number, the symbol, and the Latin letters "C" or "F" representing Celsius or Fahrenheit, respectively (e.g., 10°C). This is also the practice of the University Corporation for Atmospheric Research, which operates the National Center for Atmospheric Research. Though not recommended, use of the degree symbol without a following Latin letter is done so without a space between the number and symbol (e.g., 10°);