Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
Renaissance in the Low Countries Renaissance in the Low Countries The Renaissance in the Low Countries was a cultural period in the Northern Renaissance that took place in around the 16th century in the Low Countries (corresponding to modern-day Belgium, the Netherlands and French Flanders). Culture in the Low Countries at the end of the 15th century was influenced by the Italian Renaissance, through trade via Bruges which made Flanders wealthy. Its nobles commissioned artists who became known across Europe. In science, the anatomist Andreas Vesalius led the way; in cartography, Gerardus Mercator's map assisted explorers and navigators. In art, Dutch and Flemish Renaissance painting