Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
Mozart and smallpox wrote, 'the most terrible of all the ministers of death.' Those who survived smallpox did not always survive intact; it frequently inflicted blindness on its survivors. The survival rate was particularly low for children. The physical appearance of the disease was frightening to patients and to their caretakers: the patient's skin became covered with large, bulging pustules, which often left conspicuous pitting on the skin of patients who survived the disease. Medicine had made only slight progress against the disease in Mozart's time. Around the second decade of the 18th century the method of inoculation, which had originated in Asia,