Calcium-induced calcium release Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, e.g. in the insulin-secreting pancreatic beta cells and many
The Lost Symbol as the commands of an all-powerful deity. This interpretation has been lost amid centuries of scientific skepticism and fundamentalist zealotry. The Masons have (metaphorically) buried it, believing that, when the time is right, its rediscovery will usher in a new era of human enlightenment. "The Lost Symbol" had been in development for several years; originally expected in 2006, the projected publication date was pushed back multiple times. When officially announced, the hardcopy book was on pre-order lists for months leading up to its release, being heavily ordered both in the United States and Canada. The book was published on September