Calcium-induced calcium release of CICR across the cell causes the significant increase in cytosolic Ca that is important in activating muscle contraction. Calcium-induced calcium release Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s, it is now known that CICR is unlikely to be its primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle and it is now obvious that CICR is a widely
International breastfeeding symbol public places. These signs need to be designed carefully because they need to be understood at a glance by most people without written descriptions explaining what they mean. The International Breastfeeding Symbol was created specifically to address the perceived problem of not having a universally accepted and understood symbol for breastfeeding available in public places. The modern iconography representing infancy usually involves artificial feeding or soothing objects, like a nurser bottle icon or pacifier symbol. Nursing rooms traditionally use a baby bottle symbol to designate what they are instead of a symbol of a mother nursing a child. The International