Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Global silver trade from the 16th to 18th centuries its way across other parts of the world as well. India and Europe both received a fair amount of silver. This silver was often locally traded for other commodities, such as gold or crops. In India, silver flowed from the south to the north, and gold flowed the opposite way. Often silver and gold were manufactured into jewelry or hoarded as treasure. China was the ultimate destination in which silver would flow towards. In exchange, the Chinese traded their popular goods such as silk and porcelain. China had a high demand for silver due to its shift from paper money