Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Gin and tonic an "Evans". Although the origins of the use of lemons are unknown, their use dates back at least as far as the late 1930s. In addition lemons are often more readily available, and cheaper to purchase, than limes. The use of lemon or lime is a debated issue and while leading brands, such as Gordon's, Tanqueray and Bombay Sapphire recommend the use of lime, the founder of Fevertree Tonic Water prefers lemon. Some people garnish a Beefeater-based gin and tonic with a slice of orange, to complement the Seville oranges Beefeater uses in its botanicals. A gin and tonic served