Smallpox one-third of the cases resulted in blindness. These deaths included those of four reigning monarchs and a queen consort. In the 20th century smallpox killed 200-300 million people. Edward Jenner discovered in 1798 that vaccination could prevent smallpox. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest in 2011. The term "smallpox" was first used in Britain in the 15th century to distinguish the disease from syphilis, which was then known as the "great pox". Other historical names for the disease include pox, speckled
History of smallpox in Mexico smallpox, and when the Narvaez expedition stopped at Cozumel and Veracruz in 1520, the disease gained a foothold in the region. The introduction of smallpox among the Aztecs has been attributed to an African slave (by the name of Francisco Eguía, according to one account) but this has been disputed. From May to September, smallpox spread slowly to Tepeaca and Tlaxcala, and to Tenochtitlán by the fall of 1520. At this time, Cortes was returning to conquer the city after being thrown out on the Noche Triste. Cortes names only one indigenous leader who died of smallpox, Maxixcatzin. However, Cuitláhuac