Copper rates, and carcass dressing percentages. Chronic copper toxicity does not normally occur in humans because of transport systems that regulate absorption and excretion. Autosomal recessive mutations in copper transport proteins can disable these systems, leading to Wilson's disease with copper accumulation and cirrhosis of the liver in persons who have inherited two defective genes. Elevated copper levels have also been linked to worsening symptoms of Alzheimer's disease. In the US, the Occupational Safety and Health Administration (OSHA) has designated a permissible exposure limit (PEL) for copper dust and fumes in the workplace as a time-weighted average (TWA) of 1 mg/m.
Lead and Copper Rule improving water treatment centers, determining copper and lead levels for customers who use lead plumbing parts, and eliminating the water source as a source of lead and copper. If the lead and copper levels exceed the "action levels" water suppliers are required to educate their consumers on how to reduce exposure to lead. A 2004-2005 study of the LCR by EPA noted that the system had been effective in 96 percent of systems serving at least 3,300 people. EPA has stated that the LCR has reduced exposure to lead "that can cause damage to brain, red blood cells, and kidneys,