Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
Generalized tonic–clonic seizure hazards. Long-term therapy may include the use of antiepileptic drugs, surgical therapy, diet therapy, vagus nerve stimulation, or radio surgery. Generalized tonic-clonic seizures can have a focal onset (described above) that progresses into a generalized seizure or be a generalized seizure at onset. The term "Grand Mal" is nonspecific; referring to generalized tonic-clonic seizures with either a focal or generalized onset. Due to this lack of specificity in describing the onset of a seizure and being considered an archaic term, it is not typically used by medical professionals. Generalized tonic–clonic seizure A generalized tonic–clonic seizure (commonly known as a grand