Cumberland River Cumberland River The Cumberland River is a major waterway of the Southern United States. The river drains almost of southern Kentucky and north-central Tennessee. The river flows generally west from a source in the Appalachian Mountains to its confluence with the Ohio River near Paducah, Kentucky, and the mouth of the Tennessee River. Major tributaries include the Obey, Caney Fork, Stones, and Red rivers. Although the Cumberland River basin is predominantly rural, there are also some large cities on the river, including Nashville and Clarksville, both in Tennessee. In addition, the river system has been extensively developed for flood control,
Middlesex Township, Cumberland County, Pennsylvania 11 cross in a triangle formation near the center of the township. There is no direct access between I-76 and I-81; instead, a stretch of US 11 connects Exit 226 on I-76 with Exit 52 on I-81. The borough of Carlisle, the county seat, is about southwest of the highway crossing area via US 11, and Harrisburg, the state capital, is about to the east. The Appalachian Trail crosses the northern half of the Cumberland Valley following a route near the eastern border of Middlesex Township. According to the United States Census Bureau, the township has a total area of