Smallpox 1718. In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. In 1796, Edward Jenner, a doctor in Berkeley, Gloucestershire, rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine, from the root word "vacca", which is Latin for cow. The procedure was much safer than variolation, and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox was soon practiced all over the world. During the
Renaissance in the Low Countries Renaissance in the Low Countries The Renaissance in the Low Countries was a cultural period in the Northern Renaissance that took place in around the 16th century in the Low Countries (corresponding to modern-day Belgium, the Netherlands and French Flanders). Culture in the Low Countries at the end of the 15th century was influenced by the Italian Renaissance, through trade via Bruges which made Flanders wealthy. Its nobles commissioned artists who became known across Europe. In science, the anatomist Andreas Vesalius led the way; in cartography, Gerardus Mercator's map assisted explorers and navigators. In art, Dutch and Flemish Renaissance painting