Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Tonic (Tonic album) anyone who enjoyed their first three albums will feel comfortably at home with this music." Music reviewer Chad from music website Alternative Addiction rated the album four and half out of five stars, saying, "The contrasting melodies of tracks like “Daffodil” and “Feel It Now” show that the band hasn’t lost their knack for writing melodic rock tracks either." Tonic Additional personnel Production Tonic (Tonic album) Tonic is the self-titled fourth studio album by modern rock band Tonic. The project was originally announced in 2008, with writing and recording carrying through summer and fall of 2009. Recorded primarily at Conway