Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Prostitution in China administrative regions of China and subject to different laws: prostitution in Hong Kong is legal, as is prostitution in Macau. This has led to a higher incidence of prostitution in these regions than in mainland China. Women travel from mainland China to Hong Kong and Macau in order to engage in the trade. There are also allegations of women being trafficked for the purpose. The trafficked women are said to come from mainland China, Mongolia, Southeast Asia, Europe, and South Africa. Elizabeth Wheeler Andrew (1845–1917) and Katharine Caroline Bushnell (5 February 1856 January 26, 1946), who wrote extensively on the