Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
Malaria vaccine Malaria vaccine Malaria vaccine is a vaccine that is used to prevent malaria. The only approved vaccine as of 2015 is RTS,S. It requires four injections, and has a relatively low efficacy. Due to this low efficacy, WHO does not recommend the use of RTS,S vaccine in babies between 6 and 12 weeks of age. The vaccine is going to be studied further in Africa in 2018. Research continues into recombinant protein and attenuated whole organism vaccines. RTS,S (developed by PATH Malaria Vaccine Initiative (MVI) and GlaxoSmithKline (GSK) with support from the Bill and Melinda Gates Foundation) is the most