Tonic water and other tropical posts mixed the powder with soda and sugar, and tonic water was created. The first commercial tonic water was produced in 1858. The mixed drink gin and tonic also originated in British colonial India, when the British mixed their medicinal quinine tonic with gin. Since 2010, at least four tonic syrups have been available in the US. Consumers add carbonated water to the syrup to make tonic water, allowing drinkers to adjust the flavor intensity. Medicinal tonic water originally contained only carbonated water and a large amount of quinine. However, most tonic water today contains less quinine
History of malaria of drug-resistant and drug-sensitive malaria, especially cerebral malaria. These drugs are characterized by fast action, high efficacy and good tolerance. They kill the asexual forms of "P. berghei" and "P. cynomolgi" and have transmission-blocking activity. In 1985, Zhou Yiqing and his team combined artemether and lumefantrine into a single tablet, which was registered as a medicine in China in 1992. Later it became known as “Coartem”. Artemisinin combination treatments (ACTs) are now widely used to treat uncomplicated "falciparum" malaria, but access to ACTs is still limited in most malaria-endemic countries and only a minority of the patients who need artemisinin-based