Alpha decay helium produced on Earth is the result of the alpha decay of underground deposits of minerals containing uranium or thorium. The helium is brought to the surface as a by-product of natural gas production. Alpha particles were first described in the investigations of radioactivity by Ernest Rutherford in 1899, and by 1907 they were identified as He ions. By 1928, George Gamow had solved the theory of alpha decay via tunneling. The alpha particle is trapped in a potential well by the nucleus. Classically, it is forbidden to escape, but according to the (then) newly discovered principles of quantum mechanics,
Karyopherin alpha 2 Karyopherin alpha 2 Importin subunit alpha-2 is a protein that in humans is encoded by the "KPNA2" gene. The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import are members of the alpha importin