Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Gin and tonic a gin and tonic. On one occasion where he serves as a bartender, the audience learns that he does not know what the drink consists of. Gin and tonic is one of John Constantine's drinks of choice in the "Hellblazer" comics. Gin and tonic is also the drink of choice for hero, Cat, in Jeaniene Frost's "Night Huntress" Series. Founded in 2010, International Gin & Tonic Day is celebrated worldwide on 19 October. Gin and tonic A gin and tonic is a highball cocktail made with gin and tonic water poured over ice. It is usually garnished with a slice