Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
Double tonic including Beck's "Puttin It Down". Double tonic patterns may be classified as beginning on the lower ("Sumer is Icumen in", "The Woods so Wild", "The Irish Washerwoman") or upper (most Scottish tunes, passamezzo antico, "Roun' de Corn, Sally", "Shallow Brown", "Mkwaze mmodzi") note and may repeat open endedly, though they are often closed through a tonic close, as in : They are also often varied through a binary scheme ending on the dominant then tonic, as in: or, A variation of this last progression is the passamezzo antico. Double tonic A double tonic is a chord progression, melodic motion, or