Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
What It Is to Burn the label. Reines offered the group a chance to perform and subsequently invited his sister, and co-label owner, Stefanie to the performance. The pair were impressed and signed the group. Pre-production and demos were done at DML Studios in Escondido, California in February and April 2001. They began recording "What It Is to Burn" in June at Big Fish Studios in Encinitas, California with producer Mark Trombino. They started tracking guitars in July. Strohmeyer used Fender guitars and Marshall amplifiers. Linares used ESP guitars and Mesa amplifiers. Trombino did guitar effects for the album, earning him a programming credit in