Hepatitis In hemochromatosis, excess amounts of iron accumulate in multiple body sites, including the liver, which can lead to cirrhosis. In Wilson's disease, excess amounts of copper accumulate in the liver and brain, causing cirrhosis and dementia. When the liver is involved, alpha-1-antitrypsin deficiency and Wilson's disease tend to present as hepatitis in the neonatal period or in childhood. Hemochromatosis typically presents in adulthood, with the onset of clinical disease usually after age 50. Ischemic hepatitis (also known as shock liver) results from reduced blood flow to the liver as in shock, heart failure, or vascular insufficiency. The condition is most
Copper gluconate higher than the UL may cause liver damage. Copper gluconate Copper gluconate is the copper salt of -gluconic acid. It is an odorless light blue or blue-green crystal or powder which is easily soluble in water and insoluble in ethanol. The U.S. Institute of Medicine (IOM) sets Tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. In the case of copper the adult UL is set at 10 mg/day. Copper gluconate is sold as a dietary supplement to provide copper. The typical dose is 2.0 mg copper per day. This is one-fifth what the IOM considers