Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
Jacobson v. Massachusetts eradicate smallpox were successful in Sweden, he did not agree with the methods. He said vaccination caused him "great and extreme suffering" that he would have to endure for the rest of his life. One of his sons "suffered adverse effects" after being vaccinated as a child. Jacobson and his wife were thus resistant when it came to mandatory vaccinations in Massachusetts. A leader in his community, Jacobson was one of the few who resisted mandatory vaccinations for smallpox in the early 20th century in Cambridge, Massachusetts. While many were pleased to hear about a vaccine for smallpox, others were