Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Japanese missions to Ming China Japanese missions to Ming China Japanese missions to Ming China represent a lens for examining and evaluating the relationships between China and Japan in the 15th through the 17th centuries. The nature of these bilateral contacts encompassed political and ceremonial acknowledgment as well as cultural exchanges. The evolution of diplomatic ties accompanied the growing commercial ties which grew over time. As many as twenty trade missions traveled from Japan to China between 1401 and 1547. Every one of these missions were headed by a Zen Buddhist monk from one of the so-called or "five great Zen temples of Kyoto", consisting