Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
Sex effects of water pollution longer present much of a threat. This is also true for small amounts of chemicals present in the water. However, when there are very large amounts of chemicals, organic or inorganic, present in the water as it cycles through the atmosphere, harmful effects can be seen in areas where this water falls as precipitation. This precipitation re-enters the ongoing circulation of water pollution. Another path in which the water can circulate is by flowing directly to the ocean. Pollutants are prevalent in coastal and open-ocean waters as contaminated water flows from point sources to the sea. These pollutants are then