Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
History of smallpox in Mexico in Mexico) in which he included an introduction about what is smallpox and instructions to treat it, such as drinking warm water with salt and honey, gargling with water and vinegar, keep tidy and clean and finish treatment by taking a purgative. He thought that smallpox was a remedy of nature to clear bad mood and doctors should not accelerate the process of healing because it was against nature. He wrote a letter to propose his measures as a strategy to combat smallpox in which he also included recommendations like purify air with gunpowder and scent, ventilate churches where bodies