Fort Pitt (Pennsylvania) among Native Americans devastated the tribes of Ohio Valley and the Great Lakes areas. On August 1, 1763, most of the American Indians broke off the siege to intercept the approaching force under Colonel Bouquet. In the Battle of Bushy Run, Bouquet fought off the American Indian attack and relieved Fort Pitt on August 10. In 1772, after Pontiac's War, the British commander at Fort Pitt sold the building to two colonists, William Thompson and Alexander Ross. At that time, the Pittsburgh area was claimed by the colonies of both Virginia and Pennsylvania, which struggled for power over the region.
Siege of Fort Loudoun and continued to attack frontier settlements into 1760. In February 1760, they attacked Fort Prince George in an attempt to rescue their hostages. The fort's commander was killed. The garrison, in panicked retaliation, massacred all of the hostages. And two days later the fort fired artillery into the town of Keowee. The Cherokee now attacked Fort Ninety Six, but it withstood the siege. However, settlements and lesser posts in the South Carolina backcountry quickly fell to Cherokee raids. The Cherokee were led by Standing Turkey as Principal Chief, Oconostota ("Aganstata") of Chota, Attakullakulla ("Atagulgalu") of Tanasi, Ostenaco of Tomotley, Wauhatchie