Gin and tonic Gin and tonic A gin and tonic is a highball cocktail made with gin and tonic water poured over ice. It is usually garnished with a slice or wedge of lime. The amount of gin varies according to taste. Suggested ratios of gin to tonic are between 1:1 and 1:3. In some countries (e.g., UK), gin and tonic is also marketed pre-mixed in single-serving cans. In the United States, most bars use "soda out of a gun that in no way, shape or form resembles quinine water", according to bartender Dale DeGroff. To get a real gin and tonic, DeGroff
Human genetic resistance to malaria foothold among African populations until larger sedentary communities emerged in association with the evolution of domestic agriculture in Africa (the agricultural revolution). Several inherited variants in red blood cells have become common in parts of the world where malaria is frequent as a result of selection exerted by this parasite. This selection was historically important as the first documented example of disease as an agent of natural selection in humans. It was also the first example of genetically controlled innate immunity that operates early in the course of infections, preceding adaptive immunity which exerts effects after several days. In malaria,