Tonic water and other tropical posts mixed the powder with soda and sugar, and tonic water was created. The first commercial tonic water was produced in 1858. The mixed drink gin and tonic also originated in British colonial India, when the British mixed their medicinal quinine tonic with gin. Since 2010, at least four tonic syrups have been available in the US. Consumers add carbonated water to the syrup to make tonic water, allowing drinkers to adjust the flavor intensity. Medicinal tonic water originally contained only carbonated water and a large amount of quinine. However, most tonic water today contains less quinine
Diagnosis of malaria microscope and centrifuge that can be deployed to rural areas in the third world. "Plasmodium malariae" and "P. knowlesi" (which is the most common cause of malaria in South-east Asia) look very similar under the microscope. However, "P. knowlesi" parasitemia increases very fast and causes more severe disease than "P. malariae", so it is important to identify and treat infections quickly. Therefore, modern methods such as PCR (see "Molecular methods" below) or monoclonal antibody panels that can distinguish between the two should be used in this part of the world. For areas where microscopy is not available, or where laboratory