Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Impossible Is Nothing (Tonic Breed song) Impossible Is Nothing (Tonic Breed song) "Impossible is Nothing" is a song by heavy metal band Tonic Breed. It is the only song release from the band not to appear on a full-length studio album. The song was recorded in What it's Worth Studios in Råde, Norway, and is the first song by Tonic Breed to include Thomas Koksvik on lead guitar. On drums, the band hired a guest, Paal Johannesen. Impossible is Nothing was originally made for the Global Battle of the Bands competition, where Tonic Breed advanced to the national final in 2012. Impossible is Nothing did however