Copper toxicity toxicity. Some of the effects of aging may be associated with excess copper. One manifestation of copper toxicity, cirrhosis of the liver in children (Indian childhood cirrhosis), has been linked to boiling milk in copper cookware. The Merck Manual states recent studies suggest that a genetic defect is associated with this particular cirrhosis. An inherited condition called Wilson's disease causes the body to retain copper, since it is not excreted by the liver into the bile. This disease, if untreated, can lead to brain and liver damage, and bis-choline tetrathiomolybdate is under investigation as a therapy against Wilson's disease. Elevated
Brain-body interaction shown that brain activity in different brain areas are coupled and form brain networks that can be studied using graph theory. Brain-body interactions can be studied using a similar approach by estimating functional connectivity between brain activity and peripheral electrophysiology, for example between brain activity and ECG, EGG or EMG activity. Synchrony between slow pulse fluctuations (related to sympathetic activity) and brain fMRI signal has revealed a network of sensory brain regions that appear to be relevant for characterizing human personality and emotions. These analyses can be extended to investigate interactions between multiple organ systems that together form a brain-body