Smallpox vaccine Smallpox vaccine Smallpox vaccine, the first successful vaccine to be developed, was introduced by Edward Jenner in 1796. He followed up his observation that milkmaids who had previously caught cowpox did not later catch smallpox by showing that inoculated cowpox protected against inoculated smallpox. Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been
Rhine Campaign of 1796 Germany. By the spring of 1796, Jourdan and Moreau each had 70,000 men while Bonaparte's army numbered 63,000, including reserves and garrisons. François Christophe de Kellermann also counted 20,000 troops in the Army of the Alps holding the area between Moreau and Bonaparte on the western side of modern Switzerland; there was a smaller army in southern France that played no role in the Rhine Campaign. According to plan, Kléber made the first move, advancing south from Düsseldorf against Württemberg's wing of the Army of the Lower Rhine. On 1 June 1796, a division of Kléber's troops led by François