Malaria with other antimalarials (known as artemisinin-combination therapy, or ACT), which decreases resistance to any single drug component. These additional antimalarials include: amodiaquine, lumefantrine, mefloquine or sulfadoxine/pyrimethamine. Another recommended combination is dihydroartemisinin and piperaquine. ACT is about 90% effective when used to treat uncomplicated malaria. To treat malaria during pregnancy, the WHO recommends the use of quinine plus clindamycin early in the pregnancy (1st trimester), and ACT in later stages (2nd and 3rd trimesters). In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia. Infection with "P. vivax", "P. ovale" or "P. malariae" usually do not require
Sex effects of water pollution Sex effects of water pollution Sex is influenced by water pollutants that are encountered in everyday life. These sources of water can range from the simplicity of a water fountain to the entirety of the oceans. The pollutants within the water range from endocrine disruptor Chemicals (EDCs) in birth control to Bisphenol-A (BPA). Foreign substances such as chemical pollutants that cause an alteration of sex have been found in growing prevalence in the circulating waters of the world. These pollutants have affected not only humans, but also animals in contact with the pollutants. Endocrine Disruptor Chemicals (EDCs) are a type