Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
History of smallpox in Mexico smallpox, and when the Narvaez expedition stopped at Cozumel and Veracruz in 1520, the disease gained a foothold in the region. The introduction of smallpox among the Aztecs has been attributed to an African slave (by the name of Francisco Eguía, according to one account) but this has been disputed. From May to September, smallpox spread slowly to Tepeaca and Tlaxcala, and to Tenochtitlán by the fall of 1520. At this time, Cortes was returning to conquer the city after being thrown out on the Noche Triste. Cortes names only one indigenous leader who died of smallpox, Maxixcatzin. However, Cuitláhuac