Adrenaline of epinephrine can be seen in autonomic neuropathy or following adrenalectomy. Failure of the adrenal cortex, as with Addisons disease, can suppress epinephrine secretion as the activity of the synthesing enzyme, phenylethanolamine-"N"-methyltransferase, depends on the high concentration of cortisol that drains from the cortex to the medulla. In 1901, Jokichi Takamine patented a purified extract from the adrenal glands, and called it "adrenalin" (from the Latin for "on top of the kidneys" ("ad" and "renal"), which was trademarked by Parke, Davis & Co in the US. The British Approved Name and European Pharmacopoeia term for this drug is hence "adrenaline".
Autonomic networking as the human autonomic nervous system, each of the areas can be metaphorically related to functional and structural aspects of a living being. In the human body, the autonomic system facilitates and regulates a variety of functions including respiration, blood pressure and circulation, and emotive response. The autonomic nervous system is the interconnecting fabric that supports feedback loops between internal states and various sources by which internal and external conditions are monitored. Autognostics includes a range of self-discovery, awareness, and analysis capabilities that provide the autonomic system with a view on high-level state. In metaphor, this represents the perceptual sub-systems