Cowpox to the mild form of smallpox and the observation that dairy farmers were immune from smallpox inspired the first smallpox vaccine, created and administered by English physician Edward Jenner. The word “vaccination,” coined by Jenner in 1796, is derived from the Latin root "vaccinus", meaning of or from the cow. Once vaccinated, a patient develops antibodies that make them immune to cowpox, but they also develop immunity to the smallpox virus, or "Variola virus". The cowpox vaccinations and later incarnations proved so successful that in 1980, the World Health Organization announced that smallpox was the first disease to be eradicated
1775–82 North American smallpox epidemic Though there was not too much known about viruses and their transitions, English colonists in North America recognized the effectiveness of isolating individuals infected with smallpox. The English colonies were more aware of the features of smallpox than of almost any other infectious disease. It was widely recognized that there were only two options for protecting oneself against this disease, quarantine or inoculation against the disease. Many feared inoculation, and instead chose isolation via quarantine. Individuals with recognized infections were sent to remote locations where they could let the disease run its course without the fear of infecting others. If