Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
History of smallpox in Mexico Zacatecas. This outbreak is notable because that was the first time that sanitary and preventive campaigns were implemented in New Spain, such as quarantines, inoculation, isolation and the closing of roads. Different institutions provided health and public services to fight against the smallpox epidemic: the most important were The “Ayuntamiento” or city council. The Catholic Church and "Real Tribunal del Protomedicato", which was an institution founded in 1630, managed all sanitary aspects of New Spain including the establishment of quarantines. Charity boards were created, where rich people of the city donated money to build hospitals and to help and cure