Tonic water by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult). Still, it is often recommended as a relief for leg cramps but medical research suggests some care is needed in monitoring doses. Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. Tonic water is often used as a drink mixer for cocktails, especially gin and tonic. Vodka tonic is also popular. Tonic water with lemon or lime flavor
World Malaria Day group Malaria No More. Other former U.S. Presidents are involved in anti-malaria efforts. Former President Bill Clinton's Clinton Foundation includes an anti-malaria component that, according to director Inder Singh has distributed anti-malaria drugs to millions in Africa and Asia. Many prominent companies, organizations, and celebrities have declared initiatives to join the fight against malaria to mark this day. These include a $3 million "challenge grant" announced by ExxonMobil to match donations dollar by dollar to Malaria No More, as part of the "Idol Gives Back" episodes of American Idol, which was aired on Malaria Awareness Day. Major League Soccer Commissioner