Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Transition from Ming to Qing tribesmen and were largely acculturated to their ways. The Jurchen Manchus accepted and assimilated Han Chinese soldiers who went over to them, and Han Chinese soldiers from Liaodong often adopted and used Manchu names. Indeed Nurhaci's secretary Dahai may have been one such individual. There were too few ethnic Manchus to conquer China, but they absorbed defeated Mongols, and, more importantly, added Han Chinese to the Eight Banners. The Manchus had to create an entire "Jiu Han jun" (Old Han Army) due to the very large number of Han Chinese soldiers absorbed into the Eight Banners by both capture and