Virology in order to immunize others. In 1717 Lady Mary Wortley Montagu observed the practice in Istanbul and attempted to popularize it in Britain, but encountered considerable resistance. In 1796 Edward Jenner developed a much safer method, using cowpox to successfully immunize a young boy against smallpox, and this practice was widely adopted. Vaccinations against other viral diseases followed, including the successful rabies vaccination by Louis Pasteur in 1886. The nature of viruses however was not clear to these researchers. In 1892, the Russian biologist Dmitry Ivanovsky used a Chamberland filter to try to isolate the bacteria that caused tobacco mosaic
1775–82 North American smallpox epidemic Though there was not too much known about viruses and their transitions, English colonists in North America recognized the effectiveness of isolating individuals infected with smallpox. The English colonies were more aware of the features of smallpox than of almost any other infectious disease. It was widely recognized that there were only two options for protecting oneself against this disease, quarantine or inoculation against the disease. Many feared inoculation, and instead chose isolation via quarantine. Individuals with recognized infections were sent to remote locations where they could let the disease run its course without the fear of infecting others. If