Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Ryukyuan missions to Imperial China Ryukyuan missions to Imperial China Ryukyuan missions to Imperial China were diplomatic missions which were intermittently sent from the Ryukyuan kings to the Ming and Qing emperors. These diplomatic contacts were within the Sinocentric system of bilateral and multinational relationships in East Asia. A total of 347 Ryukyuan missions to China have been recorded. King Satto of Chūzan established formal relations with China in 1374. Satto became the first Ryukyuan king to send a mission to China. He was also the first to receive investiture and to submit to Chinese suzerainty in 1372. The Ming and Qing archival records identify