Gin and tonic plasma levels at the lower limit of therapeutic efficacy and may, in fact, cause transitory suppression of parasites". This method of consumption of quinine was impractical for malaria prophylaxis, as the amount of drug needed "can not be maintained with even large amounts of tonic". The authors conclude that it is not an effective form of treatment for malaria. In Spain, a variation on the drink called Gin-Tonic has become popular. This differs from a traditional gin and tonic as it is served in a balloon glass (copa de balon) or coupe glass with plenty of ice and a garnish
History of malaria Dmitri Leonidovich Romanowsky independently developed techniques using a mixture of Eosin Y and modified methylene blue (methylene azure) that produced a surprising hue unattributable to either staining component: a shade of purple. Malachowski used alkali-treated methylene blue solutions and Romanowsky used methylene blue solutions which were molded or aged. This new method differentiated blood cells and demonstrated the nuclei of malarial parasites. Malachowski's staining technique was one of the most significant technical advances in the history of malaria. In 1891, Paul Guttmann and Ehrlich noted that methylene blue had a high affinity for some tissues and that this dye had