Variolation shortly after variolation began to outweigh the benefits of the procedure. From the 1760s, a number of individuals, including John Fewster, Peter Plett, Benjamin Jesty, and particularly Edward Jenner, were interested in the use of material from cowpox, an animal infection, to protect against smallpox. In 1796, Jenner vaccinated James Phipps, did more vaccinations in 1798, and was the first to publish evidence that cowpox protected against smallpox, was safer than variolation, and that his vaccine could be maintained by arm-to-arm transfer. The use of variolation soon began to decline as the smallpox vaccine became widely used and its benefits
History of smallpox in Mexico were buried and to build cemeteries outside the city. This strategy was approved by City Council in September 1779. The next phase of eradication started in 1803 when Francisco Javier Balmis started the vaccination campaign in New Spain. This vaccine was used until 1951 when smallpox was declared officially eradicated in Mexico. History of smallpox in Mexico The history of smallpox in Mexico spans approximately 500 years of prevalence from the arrival of the Spanish to the official eradication in the country in 1951. It was brought to Mexico by those in Spanish ships, then spread to the center of