Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Protestantism in China strangled or expelled by the Chinese. In 1860 Protestant missions were confined to five coastal cities. By the end of the century, Western powers had forced the government to allow missionaries into the interior. During the second half of the century, increased numbers of missionaries entered the country. Scores of new missionary societies had been organized in the United States after the American Civil War and participation increased from Great Britain as well. Several thousand missionaries were working in all parts of China. The 1859 Awakening in Britain and the example of J. Hudson Taylor (1832–1905) were influential. By 1865