Opioid selling Indian opium which was smuggled into China in defiance of Chinese government bans. This led to the First (1839–1842) and Second Opium Wars (1856–1860) between China and Britain. In the 19th century, two major scientific advances were made that had far-reaching effects. Around 1804, German pharmacist Friedrich Sertürner isolated morphine from opium. He described its crystallization, structure, and pharmacological properties in a well-received paper in 1817. Morphine was the first alkaloid to be isolated from any medicinal plant, the beginning of modern scientific drug discovery. The second advance, nearly fifty years later, was the refinement of the hypodermic needle
Life of Joseph Smith from 1838 to 1839 David W. Patten. In consequence of the reports of the battle, the burning out of ex-Mormon 'apostates' by the Danites, the attack on non-Mormons in Caldwell County,the sacking of Gallatin by the Mormons and their reported plans to burn Richmond and Liberty, Missouri Governor Lilburn Boggs issued Missouri Executive Order 44, also known as the "Extermination Order" on October 27, 1838. The order stated that the Mormon community was in "open and avowed defiance of the laws, and of having made war upon the people of this State ... the Mormons must be treated as enemies, and must be exterminated