Development of the endocrine system alpha cells. The insulin concentration within the fetal pancreas is 3.6 pmol/g at seven to ten weeks, which rises to 30 pmol/g at 16–25 weeks of gestation. Near term, the insulin concentration increases to 93 pmol/g. The endocrine cells have dispersed throughout the body within 10 weeks. At 31 weeks of development, the islets of Langerhans have differentiated. While the fetal pancreas has functional beta cells by 14 to 24 weeks of gestation, the amount of insulin that is released into the bloodstream is relatively low. In a study of pregnant women carrying fetuses in the mid-gestation and near term
Islets of Granada for the residents and for tourists. Hotels and shops are established on some of the islets, and boating tours are available. The fort of San Pablo is located on the islets in Lake Nicaragua. The fort of San Pablo was built in order to protect the city of Granada from Pirates in the 18th century. The San Pablo Fort on the Islets has witnessed the battles and conflicts endured during the Colonial Period. Many residents of the islands were forced to relocate to the mainland in the 1990s after having lived there for several generations. During Somoza's dictatorship, members of