Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
What a Treat What a Treat What a Treat (foaled 1962 in Kentucky) was an American Thoroughbred racehorse who was voted the 1965 American Champion Three-Year-Old Filly and who was sold as a broodmare in 1972 at a world record price. Bred and raced by George D. Widener, Jr., she was conditioned for racing by future U.S. Racing Hall of Fame trainer Syl Veitch. As a three-year-old in 1965, What a Treat won seven of the top races for her age group, including a win over older stars Tosmah and Affectionately in capturing the Beldame Stakes. At age four, carrying high weight, What