Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Listen to What the Man Said Linda doing it. The end of the song also features a small link used to transition into the next song on "Venus and Mars", "Treat Her Gently/Lonely Old People". The song is an optimistic love song. Even though love may be blind or may cause separated lovers to suffer, the singer believes that love will prevail. This is in accordance with what “the man” said. “The man” is not explicitly identified, but might be God. Author Vincent Benitez believes that, "McCartney is advising everyone to stick with the basics of life, which for him means focusing on love." The song