Loperamide/simethicone Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the intestines. Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen. Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles
The Old Blue Mayor She Ain't What She Used to Be tonight, flock to Marge not because she’s clearly a better candidate and person than perennially elected, womanizing, cartoonishly corrupt Diamond Joe Quimby, but because resident political operative Lindsey Naegle convinces her to use Professor Frink’s micro-targeted campaigning." "The Old Blue Mayor She Ain't What She Used to Be" scored a 1.9 rating with a 7 share and was watched by 4.75 million people, making it Fox's highest rated show of the night. The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the