Loperamide/simethicone Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the intestines. Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen. Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles
What It Is to Burn the label. Reines offered the group a chance to perform and subsequently invited his sister, and co-label owner, Stefanie to the performance. The pair were impressed and signed the group. Pre-production and demos were done at DML Studios in Escondido, California in February and April 2001. They began recording "What It Is to Burn" in June at Big Fish Studios in Encinitas, California with producer Mark Trombino. They started tracking guitars in July. Strohmeyer used Fender guitars and Marshall amplifiers. Linares used ESP guitars and Mesa amplifiers. Trombino did guitar effects for the album, earning him a programming credit in