I Love to Laugh Mr. Wigg, is said to float because of an excess of "laughing gas", although it is clear that the term is not used in the chemical sense. So-called "laughing gas" (nitrous oxide) was one of the earliest effective anaesthetics developed in the Nineteenth century. it was popularised by dentists, for pain-free tooth extractions, as well as by showground novelty booths. Customers at the booth would be gassed and, as they were recovering from the drugged sleep they often felt euphoric and giggly. Hence the name. A famous 1931 British comedy sketch starring Cicely Courtneidge, called "Laughing Gas", was based on
Chemical ionization reactions for charge-exchange chemical ionization are as follows. Chemical ionization in an atmospheric pressure electric discharge is called atmospheric pressure chemical ionization (APCI), which usually uses water as the reagent gas. An APCI source is composed of a Liquid Chromatography outlet, nebulizing the eluent, a heated vaporizer tube, a corona discharge needle and a pinhole entrance to 10 torr vacuum. The analyte is a gas or liquid spray and ionization is accomplished using an atmospheric pressure corona discharge. This ionization method is often coupled with high performance liquid chromatography where the mobile phase containing eluting analyte sprayed with high flow