Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Knaster's condition Knaster's condition In mathematics, a partially ordered set "P" is said to have Knaster's condition upwards (sometimes property (K)) if any uncountable subset "A" of "P" has an upwards-linked uncountable subset. An analogous definition applies to Knaster's condition downwards. The property is named after Polish mathematician Bronisław Knaster. Knaster's condition implies the countable chain condition (ccc), and it is sometimes used in conjunction with a weaker form of Martin's axiom, where the ccc requirement is replaced with Knaster's condition. Not unlike ccc, Knaster's condition is also sometimes used as a property of a topological space, in which case it means