Pancreatic islets by scarce alpha, delta and PP cells in the periphery, human islets display alpha and beta cells in close relationship with each other throughout the cluster. Islets can influence each other through paracrine and autocrine communication, and beta cells are coupled electrically to six to seven other beta cells (but not to other cell types). The paracrine feedback system of the pancreatic islets has the following structure: A large number of G protein-coupled receptors (GPCRs) regulate the secretion of insulin, glucagon and somatostatin from pancreatic islets, and some of these GPCRs are the targets of drugs used to treat type-2
Passions of the Soul of a final cause in physics, the nature of his work on examining the origins and functions of desires in the human soul necessitates the existence of a final goal towards which the individual is working. The problem of the "Passions" treatise is also the problem of Cartesian Dualism. In the first part of his work, Descartes ponders the relationship which exists between the thinking substance and the body. For Descartes, the only link between these two substances is the pineal gland (art. 31), the place where the soul is attached to the body. The passions that Descartes studies are