Loperamide bloody diarrhea. In 1990, all formulations for children of the antidiarrheal loperamide were banned in Pakistan. Loperamide is not recommended in the UK for use during pregnancy or by nursing mothers. In the US, loperamide is classified by the FDA as pregnancy category C. Studies in rat models have shown no teratogenicity, but sufficient studies in humans have not been conducted. One controlled, prospective study of 89 women exposed to loperamide during their first trimester of pregnancy showed no increased risk of malformations. This, however, was only one study with a small sample size. Loperamide can be present in breast
St. Jude Medical had served as company chief operating officer since 2001. In January 2005, St. Jude Medical acquired Saint Paul, Minnesota-based Endocardial Solutions for $272 million. Endocardial Solutions manufactured diagnostic and therapeutic devices used to treat atrial fibrillation. Later that year the company acquired Plano, Texas-based Advanced Neuromodulation Systems for $1.3 billion. At the time of its acquisition, Advanced Neuromodulation Systems was the second-largest supplier of devices that use electrotherapy to treat chronic pain and nerve disorders. In 2008, St. Jude Medical acquired MediGuide, an Israeli company that developed technology that uses tiny sensors to locate medical devices inside of a patient's