Patrick Edward McGovern ca. 7000-6600 B.C. It was a mixed fermented beverage of rice, honey, and grape and/or hawthorn ("Crataegus pinnatifida" and "C. cuneata") fruit. The laboratory and collaborators began studying some of the most ancient chocolate from ancient Mesoamerica (ca. 1400-1100 B.C.) in 2004 Jars from Puerto Escondido in Honduras were in the shape of the cacao ("Theobroma cacao") pod or fruit, as if to advertise the contents as being a chocolate beverage. The fruit's sweet pulp contains about 15% sugar, which naturally ferments to a 5 to 7% alcoholic beverage. This beverage might have led to the domestication of the tree.
Ceratocystis cacaofunesta Ceratocystis cacaofunesta Ceratocystis cacaofunesta is an ascomycete fungus that causes a wilt disease in cacao trees. It has led to significant economic losses in Latin America. Once considered to be a form of "Ceratocystis fimbriata", the fungus was described as a new species in 2005. The specific epithet "cacaofunesta" means "cacao-killing". Two closely related sublineages exist within this species, one centered in western Ecuador and the other containing isolates from Brazil, Colombia and Costa Rica. The disease known as "Ceratocystis wilt of cacao" (or "Mal de machete") is a serious disease of the cocoa tree ("Theobroma cacao") in Latin America.