Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Medical tattoo Medical tattoo A medical tattoo is a tattoo used to treat a condition, communicate information, or mark a body location. A crude practice of corneal tattooing was performed by Galen in 150 CE. He tried to cover leukomatous opacities of the cornea by cauterizing the surface with a heated stilet and applying powdered nutgalls and iron or pulverized pomegranate bark mixed with copper salt; the practice was revived in the 1800s. With the rise of Christianity, tattooing declined and eventually became banned by a papal edict in 787 CE. The practice of corneal tattooing was revived by Louis Von Wecker