Patrick Edward McGovern ca. 7000-6600 B.C. It was a mixed fermented beverage of rice, honey, and grape and/or hawthorn ("Crataegus pinnatifida" and "C. cuneata") fruit. The laboratory and collaborators began studying some of the most ancient chocolate from ancient Mesoamerica (ca. 1400-1100 B.C.) in 2004 Jars from Puerto Escondido in Honduras were in the shape of the cacao ("Theobroma cacao") pod or fruit, as if to advertise the contents as being a chocolate beverage. The fruit's sweet pulp contains about 15% sugar, which naturally ferments to a 5 to 7% alcoholic beverage. This beverage might have led to the domestication of the tree.
Cacao swollen-shoot virus ambitious and costly eradication effort of any country in the world against a viral plant disease. Cacao swollen-shoot virus (CSSV) principally infects "Theobroma cacao" (cacao tree) and has a major effect on crop yields. Within one year of infection yields decrease by 25%, and within two years by 50%. The trees are usually killed within 3 to 4 years. Symptoms vary depending on the strain of virus. Main symptoms include: leaf chlorosis (interveinal), root necrosis, red vein banding in young leaves, small mottled pods, and stem/root swelling followed by die-back. CSSV has also been isolated from alternative hosts "Cola chlamydanta",