Pancreatic islets by scarce alpha, delta and PP cells in the periphery, human islets display alpha and beta cells in close relationship with each other throughout the cluster. Islets can influence each other through paracrine and autocrine communication, and beta cells are coupled electrically to six to seven other beta cells (but not to other cell types). The paracrine feedback system of the pancreatic islets has the following structure: A large number of G protein-coupled receptors (GPCRs) regulate the secretion of insulin, glucagon and somatostatin from pancreatic islets, and some of these GPCRs are the targets of drugs used to treat type-2
Gland Endocrine glands secrete substances that circulate through the blood stream. The glands secrete their products through basal lamina into the blood stream. Basil lamina typically can be seen a layer around the glands to which a million maybe more tiny blood vessels are attached. These glands often secrete hormones which play an important role in maintaining homeostasis. The pineal gland, thymus gland, pituitary gland, thyroid gland, and the two adrenal glands are all endocrine glands. Exocrine glands secrete their products through a duct onto an outer surface of the body, such as the skin or the gastrointestinal tract. Secretion is