Pancreatic islets by scarce alpha, delta and PP cells in the periphery, human islets display alpha and beta cells in close relationship with each other throughout the cluster. Islets can influence each other through paracrine and autocrine communication, and beta cells are coupled electrically to six to seven other beta cells (but not to other cell types). The paracrine feedback system of the pancreatic islets has the following structure: A large number of G protein-coupled receptors (GPCRs) regulate the secretion of insulin, glucagon and somatostatin from pancreatic islets, and some of these GPCRs are the targets of drugs used to treat type-2
Ryan Langerhans In 2002, Langerhans was promoted to the Double-A Greenville Braves of the Southern League. He batted .251 with 23 doubles, 2 triples, 9 home runs, and 62 RBIs in 109 games. Langerhans was called up to the Atlanta Braves from the Double-A Greenville Braves in April, 2002. He appeared in one game that season where he had one at-bat against the Houston Astros where he did not record a hit. He was sent back down to the minors to start the 2003 season where he batted a combined .261 with 33 doubles, 4 triples, 10 home runs, and 49 RBIs