Jaundice management may involve treating infectious causes and stopping medication that could be contributing. Among newborns, depending on age and prematurity, a bilirubin greater than 4–21 mg/dL (68-360 µmol/L) may be treated with phototherapy or exchanged transfusion. The itchiness may be helped by draining the gallbladder or ursodeoxycholic acid. The word "jaundice" is from the French "jaunisse", meaning "yellow disease". The main sign of jaundice is a yellowish discoloration of the white area of the eye and the skin. Urine is dark in colour. Slight increases in serum bilirubin are best detected by examining the sclerae, which have a particular affinity
Hand-colouring of photographs 1839. Coloured powder was fixed on the delicate surface of the daguerreotype by the application of heat. Variations of this technique were patented in England by Richard Beard in 1842 and in France by Étienne Lecchi in 1842 and Léotard de Leuze in 1845. Later, hand-colouring was used with successive photographic innovations, from albumen and gelatin silver prints to lantern slides and transparency photography. Parallel efforts to produce coloured photographic images affected the popularity of hand-colouring. In 1842 Daniel Davis Jr. patented a method for colouring daguerreotypes through electroplating, and his work was refined by Warren Thompson the following year.