Loperamide/simethicone Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the intestines. Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen. Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles
Mint condition have a slightly different meaning in each case. For instance, when describing trading cards, "perfect" condition is used to describe the condition as it is when pulled from a pack, while "mint" would be new but opened. Similar graduations of mint condition exist for other collectibles based on their specific characteristics. For example, a postage stamp may be mint or mint never hinged. Abbreviations include: Mint condition Mint condition is an expression used to denote the quality of a pre-owned good as displaying virtually no imperfections and being in pristine condition relative to its original production state. Originally, the phrase