Loperamide/simethicone in the intestinal tract, making them easier to pass. Simethicone is not absorbed from the gastrointestinal tract so there are no systemic side effects. Anti-diarrheal medications should be avoided if diarrhea is secondary to an infection. Avoid using such products in the presence of fever, black stools, bloody stools, or stools containing mucus. Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the
What Is to Be Done? (Tolstoy) the same Biblical reference (Luke 3:10–14). What Is to Be Done? (Tolstoy) What Is To Be Done? (sometimes translated as What Then Must We Do?) is a non-fiction work by Leo Tolstoy, in which Tolstoy describes the social conditions of Russia in his day. Tolstoy completed the book in 1886, and the first English language publication came in 1887 as What To Do?. A revised translation with the current title was published in 1899. The English title was also used for two better-known works by Nikolai Chernyshevsky and Vladimir Lenin; Tolstoy's Russian title is similar but not identical to Chernyshevsky's