Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Medical state it would confirm that the patient was receiving treatment. Medical state Medical states or medical conditions are used to describe a patient's condition (that is, their clinical status) in a hospital. These general terms are most commonly used in information given to the news media, and are rarely used as clinical descriptions by physicians, who in their daily business describe medical problems more precisely. Either or both of two aspects of the patient's state may be reported. First, the patient's current state may be reported, e.g., as being good or serious. Second, the patient's short-term prognosis may be reported, e.g.,