Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Acetic acid (medical use) Acetic acid (medical use) Acetic acid, which at low concentrations is known as vinegar, is used as a medication to treat a number of conditions. As an eardrop it is used to treat infections of the ear canal. It may be used with an ear wick. As a liquid it is used to flush the bladder in those who have a urinary catheter in an attempt to prevent infection or blockage. As a gel it may be used to adjust the pH of the vagina. It may also be applied to the cervix to help detect cervical cancer during screening.