Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Treat You Better Show", and again on October 8, 2018 with Jimmy Fallon and his house band The Roots as backing using "classroom instruments". On November 20, 2016, Mendes performed the 'Treat You Better' at the 2016 American Music Awards. "Treat You Better" is being used in a series of commercials for Southwest Airlines. In July 2017 Swedish melodic metal band Sonic Syndicate released a cover version of the song. Treat You Better "Treat You Better" is a song recorded by Canadian singer and songwriter Shawn Mendes. It was co-written by Mendes with Teddy Geiger, and Scott Harris. It was released on June