Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Acetic acid (medical use) Acetic acid (medical use) Acetic acid, which at low concentrations is known as vinegar, is used as a medication to treat a number of conditions. As an eardrop it is used to treat infections of the ear canal. It may be used with an ear wick. As a liquid it is used to flush the bladder in those who have a urinary catheter in an attempt to prevent infection or blockage. As a gel it may be used to adjust the pH of the vagina. It may also be applied to the cervix to help detect cervical cancer during screening.