Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
What a Treat What a Treat was retired to broodmare duty at owner George Widener's Old Kenney Farm near Lexington, Kentucky, where he bred her to Never Bend. Following Widener's death in December 1971, on February 12, 1972 What a Treat was auctioned through the Keeneland Sales to a breeding syndicate from France for a then world record price for a broodmare of US$450,000. Of the foals she birthed for her new owners, her mating to Northern Dancer was the most successful, producing the 1974 colt Be My Guest. Although Be My Guest proved to be a good miler who won three Conditions