Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Medical tattoo a person has diabetes mellitus; people with this condition may fall into a diabetic coma and be unable to communicate that information. Tattoos have been used as fiducial markers as an aid in guiding radiotherapy. During breast reconstruction after mastectomy (removal of the breast for treatment of cancer), or breast reduction surgery, tattooing is sometimes used to replace the areola which has been removed during mastectomy, or to fill in areas of pigment loss which may occur during breast reduction performed with a free nipple graft technique. Medical tattoo A medical tattoo is a tattoo used to treat a condition,