Theobromine Theobromine Theobromine, formerly known as xantheose, is a bitter alkaloid of the cacao plant, with the chemical formula CHNO. It is found in chocolate, as well as in a number of other foods, including the leaves of the tea plant, and the kola nut. It is classified as a xanthine alkaloid, others of which include theophylline and caffeine. The compounds differ in that caffeine has an extra methyl group (see under Pharmacology section). Despite its name, the compound contains no bromine—"theobromine" is derived from "Theobroma", the name of the genus of the cacao tree (which itself is made up of
Theobroma cacao classic period (around 400 AD) vessels from a tomb at the Maya archaeological site of Rio Azul. As cacao is the only known commodity from Mesoamerica containing both of these alkaloid compounds, it seems likely these vessels were used as containers for cacao drinks. In addition, cacao is named in a hieroglyphic text on one of the Rio Azul vessels. Cacao is also believed to have been ground by the Aztecs and mixed with tobacco for smoking purposes. Cocoa was being domesticated by the Mayo Chinchipe of the upper Amazon around 3,000 BC. Cacao beans constituted both a ritual beverage