Loperamide of a number of types of diarrhea. This includes control of acute nonspecific diarrhea, mild traveler's diarrhea, irritable bowel syndrome, chronic diarrhea due to bowel resection, and chronic diarrhea secondary to inflammatory bowel disease. It is also useful for reducing ileostomy output. Off-label uses for loperamide also include chemotherapy-induced diarrhea, especially related to irinotecan use. Loperamide should not be used as the primary treatment in cases of bloody diarrhea, acute exacerbation of ulcerative colitis, or bacterial enterocolitis. Loperamide is often compared to diphenoxylate. Recent studies suggest that loperamide is more effective and has lower neural side effects. Adverse drug reactions
Invitation to treat in the "Boots" case (described below) the offer is made by an action without any negotiations—such as presenting goods to a cashier—the offer will be presumed to be on the terms of the invitation to treat. Generally, advertisements are not offers but invitations to treat, so the person advertising is not compelled to sell. In "Partridge v Crittenden" [1968] 1 WLR 1204, a defendant who was charged with "offering for sale protected birds"—bramblefinch cocks and hens that he had advertised for sale in a newspaper—was "not" offering to sell them. Lord Parker CJ said it did not make business sense