Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Mint condition Mint condition Mint condition is an expression used to denote the quality of a pre-owned good as displaying virtually no imperfections and being in pristine condition relative to its original production state. Originally, the phrase related to the way collectors described the condition of coins. As the name given to a coin factory is a "mint", then "mint condition" is the condition a coin is in when it leaves the mint. The term "mint condition" may be used to describe a variety of collectible items, including action figures, dolls, toys, stamps, records, comic books and similar items. The term may