Patrick Edward McGovern ca. 7000-6600 B.C. It was a mixed fermented beverage of rice, honey, and grape and/or hawthorn ("Crataegus pinnatifida" and "C. cuneata") fruit. The laboratory and collaborators began studying some of the most ancient chocolate from ancient Mesoamerica (ca. 1400-1100 B.C.) in 2004 Jars from Puerto Escondido in Honduras were in the shape of the cacao ("Theobroma cacao") pod or fruit, as if to advertise the contents as being a chocolate beverage. The fruit's sweet pulp contains about 15% sugar, which naturally ferments to a 5 to 7% alcoholic beverage. This beverage might have led to the domestication of the tree.
Theobroma cacao up to 8% of cacao pods dry weight. The cacao genome appears close to the hypothetical hexaploid ancestor of all dicotyledonous plants, and it is proposed as an evolutionary mechanism by which the 21 chromosomes of the dicots' hypothetical hexaploid ancestor underwent major fusions leading to cacao's 10 chromosome pairs. The genome sequence enables cacao molecular biology and breeding for elite varieties through marker-assisted selection, in particular for genetic resistance to fungal, oomycete and viral diseases responsible for huge yield losses each year. In 2017-18, due to concerns about survivability of cacao plants in an era of global warming in