Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Murder Ain't What it Used to Be Murder Ain't What it Used to Be Murder Ain't What it Used to Be is the seventh episode of the popular 1969 ITC British television series "Randall and Hopkirk (Deceased)" starring Mike Pratt, Kenneth Cope and Annette Andre. Directed by Jeremy Summers, the episode was first broadcast on 2 November 1969 on ITV. Crime boss Paul Kirstner flies over to Great Britain from New York City to attend to "business" in London. Behind most of the rackets in Chicago, he hires Jeff to protect his daughter from any of his enemies whilst in London. However, Kirstner is being haunted by