Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
What It Is to Burn single and a music video was filmed for the track. It was directed by Alexander Kosta. The band toured with From Autumn to Ashes across the US in January and February. Allister were initially planned to support before being replaced by Steel Train. In February, the band went on a co-heading US tour with The Used. While on the tour, the "What It Is to Burn" music video was posted online on February 21. Following this, the group continued touring with The Movielife, Senses Fail and A Static Lullaby until early March. In March, the group went on a tour