Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Globus Medical Globus Medical Globus Medical, Inc., based in Audubon, Pennsylvania, is a medical device company focused on the design, development, and commercialization of musculoskeletal implants that promote healing in patients with spine disorders. Globus Medical is a publicly traded company and is listed on the NYSE under the symbol GMED. The company classifies its productsinto two categories: Innovative Fusion and Disruptive Technologies. The Innovative Fusion products are used in cervical, thoracolumbar, sacral, and interbody, corpectomy fusion procedures to treat degenerative, deformity, tumor, and trauma conditions. Globus Medical to date has developed a portfolio of spine products, releasing more than 150 products.