Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
What a Treat What a Treat was retired to broodmare duty at owner George Widener's Old Kenney Farm near Lexington, Kentucky, where he bred her to Never Bend. Following Widener's death in December 1971, on February 12, 1972 What a Treat was auctioned through the Keeneland Sales to a breeding syndicate from France for a then world record price for a broodmare of US$450,000. Of the foals she birthed for her new owners, her mating to Northern Dancer was the most successful, producing the 1974 colt Be My Guest. Although Be My Guest proved to be a good miler who won three Conditions