Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Murder Ain't What it Used to Be Murder Ain't What it Used to Be Murder Ain't What it Used to Be is the seventh episode of the popular 1969 ITC British television series "Randall and Hopkirk (Deceased)" starring Mike Pratt, Kenneth Cope and Annette Andre. Directed by Jeremy Summers, the episode was first broadcast on 2 November 1969 on ITV. Crime boss Paul Kirstner flies over to Great Britain from New York City to attend to "business" in London. Behind most of the rackets in Chicago, he hires Jeff to protect his daughter from any of his enemies whilst in London. However, Kirstner is being haunted by