Iroquois Brant's crossing of the river gave the original name to the area: Brant's Ford. By 1847, European settlers began to settle nearby and named the village Brantford. The original Mohawk settlement was on the south edge of the present-day Canadian city at a location still favorable for launching and landing canoes. In the 1830s many additional Onondaga, Oneida, Seneca, Cayuga, and Tuscarora relocated into the Indian Territory, the Province of Upper Canada, and Wisconsin. Many Iroquois (mostly Mohawk) and Iroquois-descended Métis people living in Lower Canada (primarily at Kahnawake) took employment with the Montreal-based North West Company during its existence
Iroquois have often identified the "Massawomeck / Antouhonoron" as the Haudenosaunee. In 1649, an Iroquois war party, consisting mostly of Senecas and Mohawks, destroyed the Huron village of Wendake. In turn, this ultimately resulted in the breakup of the Huron nation. With no northern enemy remaining, the Iroquois turned their forces on the Neutral Nations on the north shore of Lakes Erie and Ontario, the Susquehannocks, their southern neighbor. Then they destroyed other Iroquoian-language tribes, including the Erie, to the west, in 1654, over competition for the fur trade. Then they destroyed the Mohicans. After their victories, they reigned supreme in