Loperamide bloody diarrhea. In 1990, all formulations for children of the antidiarrheal loperamide were banned in Pakistan. Loperamide is not recommended in the UK for use during pregnancy or by nursing mothers. In the US, loperamide is classified by the FDA as pregnancy category C. Studies in rat models have shown no teratogenicity, but sufficient studies in humans have not been conducted. One controlled, prospective study of 89 women exposed to loperamide during their first trimester of pregnancy showed no increased risk of malformations. This, however, was only one study with a small sample size. Loperamide can be present in breast
Loperamide abuse were made. In 2015, however, case reports of extremely high-dose loperamide resulting in opioid misuse were published. Dubbing it “the poor man's methadone", clinicians warned that increased restrictions on the availability of prescription opioids passed in response to the opioid epidemic were prompting recreational users to turn to loperamide as an over-the-counter treatment for withdrawal symptoms. The FDA responded to these warnings by calling on drug manufacturers to voluntarily limit the availability of loperamide for public-safety reasons, in an analogous manner to restrictions put on the sales of pseudoephedrine, to be sold only in limited amounts. Since 2015, several