Insulin oscillation oscillations. The insulin oscillations are generated by pulsatile release of the hormone from the pancreas. Insulin originates from beta cells located in the islets of Langerhans. Since each islet contains up to 2000 beta cells and there are one million islets in the pancreas it is apparent that pulsatile secretion requires sophisticated synchronization both within and among the islets of Langerhans. Pulsatile insulin secretion from individual beta cells is driven by oscillation of the calcium concentration in the cells. In beta cells lacking contact, the periodicity of these oscillations is rather variable (2-10 min). However, within an islet of Langerhans
Ryan Langerhans from a game against the Padres when he injured his right shoulder after crashing into the left-field wall at San Diego's Petco Park. After coming off the 15-day disabled list, Langerhans was outrighted by the Angels. On October 6, 2012, Langerhans elected free agency. On December 18, 2012, the Toronto Blue Jays announced that Langerhans had been signed to a minor league contract with an invitation to major league spring training. Langerhans played for the Triple-A Buffalo Bisons during the 2013 season until he was released on June 21. After leaving the Bisons, Langerhans played for the Sugar Land Skeeters