Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
No Way to Treat a Lady (novel) No Way to Treat a Lady (novel) No Way to Treat a Lady is a 1964 novel by William Goldman. Goldman wrote the original novel while experiencing writer's block, when writing "Boys and Girls Together" (published in 1964). He was inspired by an article about the Boston Strangler which suggested there might be two stranglers operating, and Goldman wondered what would happen if that were the case and they got jealous of each other. (In the film adaptation, there is only one strangler; Goldman hated this change.) He says as he walked to his office, "the book simply jumped into