Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
The Old Blue Mayor She Ain't What She Used to Be The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the twenty-ninth season of the animated television series "The Simpsons", and the 624th episode of the series overall. It aired in the United States on Fox on November 12, 2017. The track of the old Springfield Monorail (from "Marge vs. the Monorail") is converted into a "sky park". At the official opening, Mayor Quimby turns on the electricity which causes the monorail car to activate and destroy the boardwalk, running down Sebastian Cobb