History of diabetes further clarified in 1921, when Sir Frederick Grant Banting and Charles Herbert Best repeated the work of Von Mering and Minkowski, and went further to demonstrate they could reverse induced diabetes in dogs by giving them an extract from the pancreatic islets of Langerhans of healthy dogs. The islets of Langerhans was discovered in 1869 by an anatomist named Paul Langerhans. He identified the keys cells in the pancreas which produce the main substance that controls glucose levels in the body. Banting, Best, and colleagues (especially the chemist Collip) went on to purify the hormone insulin from bovine pancreases at
Ryan Langerhans On April 7, Langerhans was designated for assignment to make room for Jesús Colomé. On December 14, 2010, the Mariners again re-signed Langerhans to a minor league contract. On May 9, 2011, Langerhans was again designated for assignment to make room for Mike Wilson. On July 29, 2011, Langerhans was traded to the Arizona Diamondbacks for cash considerations. Langerhans signed a minor league contract with the Los Angeles Angels of Anaheim on December 23, 2011. Ryan was recalled by the Angels on May 14, 2012, when Torii Hunter was placed on the restricted list. On May 20, Langerhans was removed