To Have and Have Not on 15 October 1937 to a first edition print-run of approximately 10,000 copies. Cosmopolitan Magazine published a section of the novel as "One Trip Across" in 1934; Esquire Magazine published a section as "The Tradesman's Return" in 1936. The novel was adapted into a 1944 film, starring Humphrey Bogart and Lauren Bacall. The film, directed by Howard Hawks, changed the story's setting from Key West to Martinique under the Vichy regime, and made significant alterations to the plot, including getting rid of Hemingway's Marxist overtones, and turning the story into a romantic thriller centering on the sparks going on between
Sleep and breathing of atonia of the pharyngeal dilator muscles and partial airway collapse. Many studies have shown this, but not all. Some have shown unchanged airway resistance during REM sleep, others have shown it to increase to NREM levels. Hypoxemia due to hypoventilation is noted in REM sleep but this is less well studied than NREM sleep. These changes are equal to or greater than NREM sleep Pulmonary arterial pressure fluctuates with respiration and rises during REM sleep. Arousals cause return of airway resistance and airflow to near awake values. Refer arousals in NREM sleep. Snoring is a condition characterized by noisy