Opioid as codeine, has similarly demonstrated little benefit in several recent studies.) Low dose morphine may help chronic cough but its use is limited by side effects. In cases of diarrhea-predominate irritable bowel syndrome, opioids may be used to suppress diarrhea. Loperamide is a peripherally selective opioid available without a prescription used to suppress diarrhea. The ability to suppress diarrhea also produces constipation when opioids are used beyond several weeks. Naloxegol, a peripherally-selective opioid antagonist is now available to treat opioid induced constipation. Opioids may help with shortness of breath particularly in advanced diseases such as cancer and COPD among others.
What Is to Be Done? What Is to Be Done? What Is To Be Done? Burning Questions of Our Movement () is a political pamphlet written by the Russian revolutionary Vladimir Lenin (credited as N. Lenin) in 1901 and published in 1902. Lenin said that the article represented "a skeleton plan to be developed in greater detail in a pamphlet now in preparation for print". Its title is inspired by the novel of the same name by the 19th century Russian revolutionary Nikolai Chernyshevsky. In "What Is to Be Done?", Lenin argues that the working class will not spontaneously become political simply by fighting economic