Loperamide/simethicone Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the intestines. Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen. Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles
What Is to Be Done? What Is to Be Done? What Is To Be Done? Burning Questions of Our Movement () is a political pamphlet written by the Russian revolutionary Vladimir Lenin (credited as N. Lenin) in 1901 and published in 1902. Lenin said that the article represented "a skeleton plan to be developed in greater detail in a pamphlet now in preparation for print". Its title is inspired by the novel of the same name by the 19th century Russian revolutionary Nikolai Chernyshevsky. In "What Is to Be Done?", Lenin argues that the working class will not spontaneously become political simply by fighting economic