Loperamide/simethicone Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the intestines. Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen. Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles
What a Treat What a Treat was retired to broodmare duty at owner George Widener's Old Kenney Farm near Lexington, Kentucky, where he bred her to Never Bend. Following Widener's death in December 1971, on February 12, 1972 What a Treat was auctioned through the Keeneland Sales to a breeding syndicate from France for a then world record price for a broodmare of US$450,000. Of the foals she birthed for her new owners, her mating to Northern Dancer was the most successful, producing the 1974 colt Be My Guest. Although Be My Guest proved to be a good miler who won three Conditions