Loperamide/simethicone Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the intestines. Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen. Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles
No Way to Treat a Lady (novel) No Way to Treat a Lady (novel) No Way to Treat a Lady is a 1964 novel by William Goldman. Goldman wrote the original novel while experiencing writer's block, when writing "Boys and Girls Together" (published in 1964). He was inspired by an article about the Boston Strangler which suggested there might be two stranglers operating, and Goldman wondered what would happen if that were the case and they got jealous of each other. (In the film adaptation, there is only one strangler; Goldman hated this change.) He says as he walked to his office, "the book simply jumped into