Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Medical state Medical state Medical states or medical conditions are used to describe a patient's condition (that is, their clinical status) in a hospital. These general terms are most commonly used in information given to the news media, and are rarely used as clinical descriptions by physicians, who in their daily business describe medical problems more precisely. Either or both of two aspects of the patient's state may be reported. First, the patient's current state may be reported, e.g., as being good or serious. Second, the patient's short-term prognosis may be reported, e.g., that the patient is improving, is getting worse, or