Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
What It Is to Burn single and a music video was filmed for the track. It was directed by Alexander Kosta. The band toured with From Autumn to Ashes across the US in January and February. Allister were initially planned to support before being replaced by Steel Train. In February, the band went on a co-heading US tour with The Used. While on the tour, the "What It Is to Burn" music video was posted online on February 21. Following this, the group continued touring with The Movielife, Senses Fail and A Static Lullaby until early March. In March, the group went on a tour