Insulin oscillation oscillations. The insulin oscillations are generated by pulsatile release of the hormone from the pancreas. Insulin originates from beta cells located in the islets of Langerhans. Since each islet contains up to 2000 beta cells and there are one million islets in the pancreas it is apparent that pulsatile secretion requires sophisticated synchronization both within and among the islets of Langerhans. Pulsatile insulin secretion from individual beta cells is driven by oscillation of the calcium concentration in the cells. In beta cells lacking contact, the periodicity of these oscillations is rather variable (2-10 min). However, within an islet of Langerhans
Carotid body sustentacular supportive cells. The carotid body contains the most vascularized tissue in the human body . The thyroid gland is very vascular, but not quite as much as the carotid body. The carotid body functions as a sensor: it responds to a stimulus, primarily O partial pressure, which is detected by the type I (glomus) cells, and triggers an action potential through the afferent fibers of the glossopharyngeal nerve, which relays the information to the central nervous system. The carotid body chemoreceptors are primarily sensitive to decreases in the partial pressure of oxygen (P). This is in contrast to the