Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
What a Treat a Treat finished off the board in the February 15, 1966 Columbiana Handicap at Florida's Hialeah Park Race Track. On that same track, she then won the March 2 Black Helen Handicap and won again at Aqueduct Racetrack on April 14 before running second in the Bed O' Roses Handicap. The rest of her 1966 campaign brought What a Treat limited success, with her finishing off the board in important races such as the Diana Handicap, Ladies Handicap, and Maskette Handicap. Although What a Treat was in training in May 1967, her career ended that year without further racing success.