Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Mint condition have a slightly different meaning in each case. For instance, when describing trading cards, "perfect" condition is used to describe the condition as it is when pulled from a pack, while "mint" would be new but opened. Similar graduations of mint condition exist for other collectibles based on their specific characteristics. For example, a postage stamp may be mint or mint never hinged. Abbreviations include: Mint condition Mint condition is an expression used to denote the quality of a pre-owned good as displaying virtually no imperfections and being in pristine condition relative to its original production state. Originally, the phrase