Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Globus Medical Globus Medical Globus Medical, Inc., based in Audubon, Pennsylvania, is a medical device company focused on the design, development, and commercialization of musculoskeletal implants that promote healing in patients with spine disorders. Globus Medical is a publicly traded company and is listed on the NYSE under the symbol GMED. The company classifies its productsinto two categories: Innovative Fusion and Disruptive Technologies. The Innovative Fusion products are used in cervical, thoracolumbar, sacral, and interbody, corpectomy fusion procedures to treat degenerative, deformity, tumor, and trauma conditions. Globus Medical to date has developed a portfolio of spine products, releasing more than 150 products.