Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Medical tattoo a person has diabetes mellitus; people with this condition may fall into a diabetic coma and be unable to communicate that information. Tattoos have been used as fiducial markers as an aid in guiding radiotherapy. During breast reconstruction after mastectomy (removal of the breast for treatment of cancer), or breast reduction surgery, tattooing is sometimes used to replace the areola which has been removed during mastectomy, or to fill in areas of pigment loss which may occur during breast reduction performed with a free nipple graft technique. Medical tattoo A medical tattoo is a tattoo used to treat a condition,