Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
What It Is to Burn the label. Reines offered the group a chance to perform and subsequently invited his sister, and co-label owner, Stefanie to the performance. The pair were impressed and signed the group. Pre-production and demos were done at DML Studios in Escondido, California in February and April 2001. They began recording "What It Is to Burn" in June at Big Fish Studios in Encinitas, California with producer Mark Trombino. They started tracking guitars in July. Strohmeyer used Fender guitars and Marshall amplifiers. Linares used ESP guitars and Mesa amplifiers. Trombino did guitar effects for the album, earning him a programming credit in