Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Charles Treat Stotsenburg, Philippines, remaining on active duty until retiring in 1922. In 1930 he was promoted to Major General on the retired list. Treat received the Army Distinguished Service Medal for his World War I service. He was also a recipient of the Order of the White Eagle (Serbia) with swords and the Italian Order of Saints Maurice and Lazarus. His Distinguished Service Medal citation reads: Treat resided in Washington, D.C., and died at Walter Reed Army Medical Center on October 11, 1941. He is buried at West Point Cemetery, Section 1, Site B-25. In 1889 Treat married Margaret Louise Cornell,