Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Mint condition have a slightly different meaning in each case. For instance, when describing trading cards, "perfect" condition is used to describe the condition as it is when pulled from a pack, while "mint" would be new but opened. Similar graduations of mint condition exist for other collectibles based on their specific characteristics. For example, a postage stamp may be mint or mint never hinged. Abbreviations include: Mint condition Mint condition is an expression used to denote the quality of a pre-owned good as displaying virtually no imperfections and being in pristine condition relative to its original production state. Originally, the phrase