Loperamide bloody diarrhea. In 1990, all formulations for children of the antidiarrheal loperamide were banned in Pakistan. Loperamide is not recommended in the UK for use during pregnancy or by nursing mothers. In the US, loperamide is classified by the FDA as pregnancy category C. Studies in rat models have shown no teratogenicity, but sufficient studies in humans have not been conducted. One controlled, prospective study of 89 women exposed to loperamide during their first trimester of pregnancy showed no increased risk of malformations. This, however, was only one study with a small sample size. Loperamide can be present in breast
Pre-existing condition The University of Pittsburgh Medical Center defines a pre-existing condition as a "medical condition that occurred before a program of health benefits went into effect". J. James Rohack, president of the American Medical Association, has stated on a "Fox News Sunday" interview that exclusions, based upon these conditions, function as a form of "rationing" of health care. Conditions can be broken down into two further categories, according to Lisa Smith of Investopedia: Which definition may be used was sometimes regulated by state laws. Some states required insurance companies to use the objective standard, while others required the prudent person standard.