Development of the endocrine system alpha cells. The insulin concentration within the fetal pancreas is 3.6 pmol/g at seven to ten weeks, which rises to 30 pmol/g at 16–25 weeks of gestation. Near term, the insulin concentration increases to 93 pmol/g. The endocrine cells have dispersed throughout the body within 10 weeks. At 31 weeks of development, the islets of Langerhans have differentiated. While the fetal pancreas has functional beta cells by 14 to 24 weeks of gestation, the amount of insulin that is released into the bloodstream is relatively low. In a study of pregnant women carrying fetuses in the mid-gestation and near term
Ryan Langerhans from a game against the Padres when he injured his right shoulder after crashing into the left-field wall at San Diego's Petco Park. After coming off the 15-day disabled list, Langerhans was outrighted by the Angels. On October 6, 2012, Langerhans elected free agency. On December 18, 2012, the Toronto Blue Jays announced that Langerhans had been signed to a minor league contract with an invitation to major league spring training. Langerhans played for the Triple-A Buffalo Bisons during the 2013 season until he was released on June 21. After leaving the Bisons, Langerhans played for the Sugar Land Skeeters