Opioid as codeine, has similarly demonstrated little benefit in several recent studies.) Low dose morphine may help chronic cough but its use is limited by side effects. In cases of diarrhea-predominate irritable bowel syndrome, opioids may be used to suppress diarrhea. Loperamide is a peripherally selective opioid available without a prescription used to suppress diarrhea. The ability to suppress diarrhea also produces constipation when opioids are used beyond several weeks. Naloxegol, a peripherally-selective opioid antagonist is now available to treat opioid induced constipation. Opioids may help with shortness of breath particularly in advanced diseases such as cancer and COPD among others.
What Is History? sometimes been made to treat history as a branch of sociology." About the rise of social history as a subject at the expense of political history, Carr wrote:"Social history is the bedrock. To study the bedrock alone is not enough; and becomes tedious; perhaps this is what happened to Annales. But you can't dispense with it". Through Carr himself had insisted that history was a social science, he regretted the decline of history as a discipline relative to the other social sciences, which he saw as a part of a conservative trend. Carr wrote: "History is preoccupied with fundamental processes