Theobroma cacao which climates become more extreme in the narrow band of latitudes where cacao is grown (20 degrees north and south of the equator), the commercial company, Mars, Incorporated and the University of California, Berkeley are using CRISPR to adjust DNA for improved hardiness of cacao in hot climates. Theobroma cacao Theobroma cacao, also called the cacao tree and the cocoa tree, is a small ( tall) evergreen tree in the family Malvaceae, native to the deep tropical regions of the Americas. Its seeds, cocoa beans, are used to make cocoa mass, cocoa powder, confectionery, ganache and chocolate. Leaves are alternate,
Cacao necrosis virus translucent veinal necrosis of leaves, necrotic or chlorotic spots of leaves, defoliation, and dieback of shoots that rarely leads to seedling death if infected by the Ghanaian isolate. A following recovery phase of live plants shows limited leaf symptoms. The virus has been transmitted to numerous diagnostically susceptible host species including "Beta vulgaris", "Chenopodium amaranticolor", "Chenopodium quinoa", "Cucumis sativus", "Glycine max", "Gomphrena globosa", "Nicotiana clevelandii", "Nicotiana glutinosa", "Nicotiana tabacum", "Petunia × hybrida", "Phaseolus vulgaris", "Tetragonia tetragonioides", "Theobroma cacao", and "Vigna unguiculata", but these plants are not infected in nature. The strain used to infect these species was the Ghanian isolate.