Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Knaster's condition Knaster's condition In mathematics, a partially ordered set "P" is said to have Knaster's condition upwards (sometimes property (K)) if any uncountable subset "A" of "P" has an upwards-linked uncountable subset. An analogous definition applies to Knaster's condition downwards. The property is named after Polish mathematician Bronisław Knaster. Knaster's condition implies the countable chain condition (ccc), and it is sometimes used in conjunction with a weaker form of Martin's axiom, where the ccc requirement is replaced with Knaster's condition. Not unlike ccc, Knaster's condition is also sometimes used as a property of a topological space, in which case it means