Iroquois Brant's crossing of the river gave the original name to the area: Brant's Ford. By 1847, European settlers began to settle nearby and named the village Brantford. The original Mohawk settlement was on the south edge of the present-day Canadian city at a location still favorable for launching and landing canoes. In the 1830s many additional Onondaga, Oneida, Seneca, Cayuga, and Tuscarora relocated into the Indian Territory, the Province of Upper Canada, and Wisconsin. Many Iroquois (mostly Mohawk) and Iroquois-descended Métis people living in Lower Canada (primarily at Kahnawake) took employment with the Montreal-based North West Company during its existence
Iroquois Falls used for official temperature readings. Winter typically lasts from November through April. Resolute Forest Products announced the permanent closure of its mill in Iroquois Falls on December 5, 2014, eliminating 180 jobs. Mayor Michael Shea commented: "it's going to affect every village in Northern Ontario." In 2015, the Town of Iroquois Falls entered into an agreement with Resolute Forest Products, and Riverside Developments, regarding redeveloping the former mill site into a multi-use industrial facility, commercial-industrial park, or possibly a greenhouse complex. The Jus Jordan Arena arena and curling rinks were completed in 1955, entirely through the volunteer effort of townspeople.