Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
What It Is to Burn the label. Reines offered the group a chance to perform and subsequently invited his sister, and co-label owner, Stefanie to the performance. The pair were impressed and signed the group. Pre-production and demos were done at DML Studios in Escondido, California in February and April 2001. They began recording "What It Is to Burn" in June at Big Fish Studios in Encinitas, California with producer Mark Trombino. They started tracking guitars in July. Strohmeyer used Fender guitars and Marshall amplifiers. Linares used ESP guitars and Mesa amplifiers. Trombino did guitar effects for the album, earning him a programming credit in