Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
Herb Treat the player-coach of Boston's first professional football team—the Boston Bulldogs in the first American Football League. The team lasted only six games, playing one home game in Braves Field and one in Fenway Park. In 1927, Treat played a role in the rescue of four youths who broke through the ice on Boston's Jamaica Pond. During World War II, Treat worked at Bethlehem Steel Co.'s Hingham Shipyard. He suffered serious head injuries in August 1943 when he was struck by an automobile while crossing the street in Weymouth, Massachusetts. He was in critical condition on arrival and spent several days