Loperamide 1980s, prior to the expiration of US patent on 30 January 1990, McNeil company started to develop Imodium Advanced containing loperamide and simethicone for treating both diarrhea and gas. In March 1997, the company patented such combination. The drug was approved in June 1997 by the FDA as Imodium Multi-Symptom Relief in the form of a chewable tablet. In November 1993, loperamide was launched as an orally disintegrating tablet based on Zydis technology. Imodium Instant Melts from Johnson & Johnson is currently the only loperamide available in the form of orally disintegrating tablets. In 2013, loperamide in the form of
What Is to Be Done? What Is to Be Done? What Is To Be Done? Burning Questions of Our Movement () is a political pamphlet written by the Russian revolutionary Vladimir Lenin (credited as N. Lenin) in 1901 and published in 1902. Lenin said that the article represented "a skeleton plan to be developed in greater detail in a pamphlet now in preparation for print". Its title is inspired by the novel of the same name by the 19th century Russian revolutionary Nikolai Chernyshevsky. In "What Is to Be Done?", Lenin argues that the working class will not spontaneously become political simply by fighting economic