Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
What a Treat a Treat finished off the board in the February 15, 1966 Columbiana Handicap at Florida's Hialeah Park Race Track. On that same track, she then won the March 2 Black Helen Handicap and won again at Aqueduct Racetrack on April 14 before running second in the Bed O' Roses Handicap. The rest of her 1966 campaign brought What a Treat limited success, with her finishing off the board in important races such as the Diana Handicap, Ladies Handicap, and Maskette Handicap. Although What a Treat was in training in May 1967, her career ended that year without further racing success.