Loperamide/simethicone Loperamide/simethicone Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. Loperamide is a μ-opioid receptor agonist that works in the intestines. Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen. Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles
What Is History? sometimes been made to treat history as a branch of sociology." About the rise of social history as a subject at the expense of political history, Carr wrote:"Social history is the bedrock. To study the bedrock alone is not enough; and becomes tedious; perhaps this is what happened to Annales. But you can't dispense with it". Through Carr himself had insisted that history was a social science, he regretted the decline of history as a discipline relative to the other social sciences, which he saw as a part of a conservative trend. Carr wrote: "History is preoccupied with fundamental processes