History of diabetes further clarified in 1921, when Sir Frederick Grant Banting and Charles Herbert Best repeated the work of Von Mering and Minkowski, and went further to demonstrate they could reverse induced diabetes in dogs by giving them an extract from the pancreatic islets of Langerhans of healthy dogs. The islets of Langerhans was discovered in 1869 by an anatomist named Paul Langerhans. He identified the keys cells in the pancreas which produce the main substance that controls glucose levels in the body. Banting, Best, and colleagues (especially the chemist Collip) went on to purify the hormone insulin from bovine pancreases at
Ryan Langerhans from a game against the Padres when he injured his right shoulder after crashing into the left-field wall at San Diego's Petco Park. After coming off the 15-day disabled list, Langerhans was outrighted by the Angels. On October 6, 2012, Langerhans elected free agency. On December 18, 2012, the Toronto Blue Jays announced that Langerhans had been signed to a minor league contract with an invitation to major league spring training. Langerhans played for the Triple-A Buffalo Bisons during the 2013 season until he was released on June 21. After leaving the Bisons, Langerhans played for the Sugar Land Skeeters