Loperamide have negative effects from rebound constipation. If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as or "Salmonella", loperamide is contraindicated as a primary treatment. Loperamide treatment is not used in symptomatic "C. difficile" infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. Additionally, caution should be used when treating people with advanced HIV, as cases of both viral and bacterial toxic megacolon have been reported. If abdominal distension is noted, therapy
Charles Treat Stotsenburg, Philippines, remaining on active duty until retiring in 1922. In 1930 he was promoted to Major General on the retired list. Treat received the Army Distinguished Service Medal for his World War I service. He was also a recipient of the Order of the White Eagle (Serbia) with swords and the Italian Order of Saints Maurice and Lazarus. His Distinguished Service Medal citation reads: Treat resided in Washington, D.C., and died at Walter Reed Army Medical Center on October 11, 1941. He is buried at West Point Cemetery, Section 1, Site B-25. In 1889 Treat married Margaret Louise Cornell,