To Have and Have Not on 15 October 1937 to a first edition print-run of approximately 10,000 copies. Cosmopolitan Magazine published a section of the novel as "One Trip Across" in 1934; Esquire Magazine published a section as "The Tradesman's Return" in 1936. The novel was adapted into a 1944 film, starring Humphrey Bogart and Lauren Bacall. The film, directed by Howard Hawks, changed the story's setting from Key West to Martinique under the Vichy regime, and made significant alterations to the plot, including getting rid of Hemingway's Marxist overtones, and turning the story into a romantic thriller centering on the sparks going on between
Sleep and weight see them start to shed pounds, especially in obese individuals. What causes this phenomenon? Two hormones, ghrelin and leptin, closely associated with appetite are key in the sleep and weight relationship. Ghrelin is the hormone that controls appetite and tells the body when to eat, and when one is sleep-deprived, they have more ghrelin. Leptin on the other hand, is the hormone that tells one to stop eating, and when an individuals is sleep deprived, they have less leptin. In order to keep these hormone levels in balance, a person needs to get adequate sleep so they do not feel