Pancreatic islets and transdifferentiate into beta cells in both healthy and diabetic human and mouse pancreatic islets, a possible future source for beta cell regeneration. Pancreatic islets The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. The pancreatic islets constitute 1 to 2% of the pancreas volume and receive 10–15% of its blood flow. The pancreatic islets are arranged in density routes throughout the human pancreas, and are important in the metabolism of glucose. There are about 3 million islets distributed in the
Islets of Granada for the residents and for tourists. Hotels and shops are established on some of the islets, and boating tours are available. The fort of San Pablo is located on the islets in Lake Nicaragua. The fort of San Pablo was built in order to protect the city of Granada from Pirates in the 18th century. The San Pablo Fort on the Islets has witnessed the battles and conflicts endured during the Colonial Period. Many residents of the islands were forced to relocate to the mainland in the 1990s after having lived there for several generations. During Somoza's dictatorship, members of