Insulin oscillation oscillations. The insulin oscillations are generated by pulsatile release of the hormone from the pancreas. Insulin originates from beta cells located in the islets of Langerhans. Since each islet contains up to 2000 beta cells and there are one million islets in the pancreas it is apparent that pulsatile secretion requires sophisticated synchronization both within and among the islets of Langerhans. Pulsatile insulin secretion from individual beta cells is driven by oscillation of the calcium concentration in the cells. In beta cells lacking contact, the periodicity of these oscillations is rather variable (2-10 min). However, within an islet of Langerhans
Ryan Langerhans On April 7, Langerhans was designated for assignment to make room for Jesús Colomé. On December 14, 2010, the Mariners again re-signed Langerhans to a minor league contract. On May 9, 2011, Langerhans was again designated for assignment to make room for Mike Wilson. On July 29, 2011, Langerhans was traded to the Arizona Diamondbacks for cash considerations. Langerhans signed a minor league contract with the Los Angeles Angels of Anaheim on December 23, 2011. Ryan was recalled by the Angels on May 14, 2012, when Torii Hunter was placed on the restricted list. On May 20, Langerhans was removed