Pancreatic islets by scarce alpha, delta and PP cells in the periphery, human islets display alpha and beta cells in close relationship with each other throughout the cluster. Islets can influence each other through paracrine and autocrine communication, and beta cells are coupled electrically to six to seven other beta cells (but not to other cell types). The paracrine feedback system of the pancreatic islets has the following structure: A large number of G protein-coupled receptors (GPCRs) regulate the secretion of insulin, glucagon and somatostatin from pancreatic islets, and some of these GPCRs are the targets of drugs used to treat type-2
Ryan Langerhans On April 7, Langerhans was designated for assignment to make room for Jesús Colomé. On December 14, 2010, the Mariners again re-signed Langerhans to a minor league contract. On May 9, 2011, Langerhans was again designated for assignment to make room for Mike Wilson. On July 29, 2011, Langerhans was traded to the Arizona Diamondbacks for cash considerations. Langerhans signed a minor league contract with the Los Angeles Angels of Anaheim on December 23, 2011. Ryan was recalled by the Angels on May 14, 2012, when Torii Hunter was placed on the restricted list. On May 20, Langerhans was removed