Cast of ER Cast of ER "ER" is an American drama series that aired on NBC from September 19, 1994 until April 2, 2009. The series featured a large ensemble cast that changed dramatically over its long run. The main cast was augmented by a wealth of recurring characters and award-winning guest stars. The original starring cast consisted of Anthony Edwards as Dr. Mark Greene, George Clooney as Dr. Douglas "Doug" Ross, Sherry Stringfield as Dr. Susan Lewis, Noah Wyle as medical student (later Dr.) John Carter, and Eriq La Salle as Dr. Peter Benton. Julianna Margulies guest starred in the pilot as
Noah Wyle he returned in guest appearances for a four-episode arc during the twelfth season. He stated that he left because he wanted to spend more time with his family and friends and to make room for the upcoming generation. However, in 2009, Wyle returned to "ER" during its fifteenth and final season for five episodes, including the series finale. According to the Guinness World Records 2005 Special 50th Anniversary Edition, Wyle became the holder of a "Highest paid TV drama actor per episode" record during the 2003–2004 tenth season, earning approximately $400,000 per episode. While on "ER", Wyle's estimated salary was