Nucleic acid hybridization natural positions within a chromosome). In 1969, the two scientists published a paper demonstrating that radioactive copies of a ribosomal DNA sequence could be used to detect complementary DNA sequences in the nucleus of a frog egg. Since those original observations, many refinements have increased the versatility and sensitivity of the procedure to the extent that in situ hybridization is now considered an essential tool in cytogenetics. Nucleic acid hybridization In molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA. Though a double-stranded DNA
Hydroiodic acid Hydroiodic acid Hydroiodic acid (or hydriodic acid) is a highly acidic aqueous solution of hydrogen iodide (HI) (concentrated solution usually 48 - 57% HI). It is the second strongest hydrohalic acid, after hydroastatic acid. Hydroiodic acid is a commonly used chemical reagent and is one of the strong acids that ionize completely in an aqueous solution. Concentrated hydroiodic acid has a pH of less than 0. Hydroiodic acid readily reacts with oxygen in air, contributing to the deep colours associated with old samples; Like other halogens, hydroiodic acid will perform addition reactions with unsaturated hydrocarbons such as alkenes. The Cativa