Nucleic acid hybridization natural positions within a chromosome). In 1969, the two scientists published a paper demonstrating that radioactive copies of a ribosomal DNA sequence could be used to detect complementary DNA sequences in the nucleus of a frog egg. Since those original observations, many refinements have increased the versatility and sensitivity of the procedure to the extent that in situ hybridization is now considered an essential tool in cytogenetics. Nucleic acid hybridization In molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA. Though a double-stranded DNA
Silicotungstic acid Silicotungstic acid Silicotungstic acid (also known as tungstosilicic acid) is the most commonly encountered heteropoly acid. It is a pale yellow solid with the chemical formula H[WSiO]. It is used as a catalyst in the chemical industry. Silicotungstic acid is used to manufacture ethyl acetate by the alkylation of acetic acid by ethylene: It has also been commercialized for the oxidation of ethylene to acetic acid: This route is claimed as a "greener" than methanol carbonylation. The heteropoly acid is dispersed on silica gel at 20-30 wt% to maximize catalytic ability. It has also recently been proposed as a mediator