Nucleic acid hybridization natural positions within a chromosome). In 1969, the two scientists published a paper demonstrating that radioactive copies of a ribosomal DNA sequence could be used to detect complementary DNA sequences in the nucleus of a frog egg. Since those original observations, many refinements have increased the versatility and sensitivity of the procedure to the extent that in situ hybridization is now considered an essential tool in cytogenetics. Nucleic acid hybridization In molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA. Though a double-stranded DNA
Hexafluorosilicic acid Hexafluorosilicic acid Hexafluorosilicic acid is an inorganic compound with the chemical formula (also written as ). It is a colorless liquid rarely encountered undiluted. Hexafluorosilicic acid has a distinctive sour taste and pungent smell. It is produced naturally on a large scale in volcanoes. It is manufactured as a precursor to aluminum trifluoride and synthetic cryolite. It is commonly used as a source of fluoride for water fluoridation. Salts derived from hexafluorosilicic acid are called hexafluorosilicates. In aqueous solution, the hydronium cation (HO) is traditionally equated with a solvated proton, and as such, the formula for this compound is often