Nucleic acid hybridization natural positions within a chromosome). In 1969, the two scientists published a paper demonstrating that radioactive copies of a ribosomal DNA sequence could be used to detect complementary DNA sequences in the nucleus of a frog egg. Since those original observations, many refinements have increased the versatility and sensitivity of the procedure to the extent that in situ hybridization is now considered an essential tool in cytogenetics. Nucleic acid hybridization In molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA. Though a double-stranded DNA
What Work Is Fame" and "Growth" are direct accounts of two of Levine's jobs as a young man. "Fear and Fame" is based on a job Levine had cleaning out and refilling acid vats in his mid twenties. "Growth" is about the job Levine held at a soap factory at the age of fourteen. Many of Levine's poems are based on his experience growing up in Detroit. The titular poem, "What Work Is", is based on Levine's experience of waiting in a Detroit employment line. "The Right Cross" is related to a boxing teacher who taught Levine to defend himself while growing up