Epicanthic fold facial similarities (epicanthic folds) with those of Blumenbach's Mongolian race. While the term "mongoloid" (also "mongol" or "mongoloid idiot") continued to be used until the early 1970s, it is now considered pejorative and inaccurate and is no longer in common use about medical conditions. In Zellweger syndrome, epicanthic folds are prominent. Other examples are fetal alcohol syndrome, phenylketonuria, and Turner syndrome. Epicanthic fold The epicanthic fold is the skin fold of the upper eyelid, covering the inner corner (medial canthus) of the eye. Various factors influence whether epicanthic folds form, including ancestry, age, and certain medical conditions. The highest frequency
Fold change ""X"-fold increase". As such, several dictionaries, including the Oxford English Dictionary and Merriam-Webster Dictionary, as well as Collins's Dictionary of Mathematics, define "-fold" to mean "times", as in "2-fold" = "2 times" = "double". Likely because of this definition, many scientists use not only "fold", but also "fold change" to be synonymous with "times", as in "3-fold larger" = "3 times larger".. More ambiguous is fold decrease, where, for instance, a decrease of 50% between two measurements would generally be referred to a "half-fold change" rather than a "2-fold decrease". Fold change is often used in analysis of gene expression