Cast of ER Cast of ER "ER" is an American drama series that aired on NBC from September 19, 1994 until April 2, 2009. The series featured a large ensemble cast that changed dramatically over its long run. The main cast was augmented by a wealth of recurring characters and award-winning guest stars. The original starring cast consisted of Anthony Edwards as Dr. Mark Greene, George Clooney as Dr. Douglas "Doug" Ross, Sherry Stringfield as Dr. Susan Lewis, Noah Wyle as medical student (later Dr.) John Carter, and Eriq La Salle as Dr. Peter Benton. Julianna Margulies guest starred in the pilot as
Parminder Nagra and Mekhi Phifer, Nagra became the longest-serving cast member and lead actor of "ER" and remained so until the series concluded with season 15: episode 22, the two-hour series finale titled "And in the End..." which aired on 2 April 2009. When Nagra finished filming the eleventh season of "ER" in 2005, she returned to her native Leicester to star in "Love in Little India" directed by Amit Gupta. She was nominated in 2006 for an Asian Excellence Award, in the category of Outstanding Female Television Performance, for her work in "ER", and won the award the following year. Nagra