Epicanthic fold Epicanthic fold The epicanthic fold is the skin fold of the upper eyelid, covering the inner corner (medial canthus) of the eye. Various factors influence whether epicanthic folds form, including ancestry, age, and certain medical conditions. The highest frequency of occurrence of epicanthic folds are found in: East Asians, Southeast Asians, Central Asians, North Asians, some South Asians, Polynesians, Micronesians, Indigenous Americans (as well as Mestizos), the Khoisan, Malagasy. In some of these populations the trait is almost universal. Epicanthic folds occur, but at considerably lower frequency, in: Europeans (e.g., Scandinavians, English, Irish, Hungarians, Russians, Poles, Lithuanians, Finns, Estonians and
Nasal bridge canthorum, which is a lateral displacement of the inner canthi of the eyes. Dystopia canthorum is associated with Waardenburg syndrome. Nasal bridge The nasal bridge is the upper, bony part of the human nose, which overlies the nasal bones. Low-rooted nasal bridges are closely associated with epicanthic folds. A lower nasal bridge is more likely to cause an epicanthic fold, and vice versa. A lower or higher than average nasal bridge can be a sign of various genetic disorders, such as fetal alcohol syndrome. A flat nasal bridge can be a sign of Down syndrome (Trisomy 21), Fragile X syndrome,