Nucleic acid thermodynamics of base incompatibility by quantifying the temperature at which two strands anneal can provide information as to the similarity in base sequence between the two strands being annealed. The complexes may be dissociated by thermal denaturation, also referred to as melting. In the absence of external negative factors, the processes of hybridization and melting may be repeated in succession indefinitely, which lays the ground for polymerase chain reaction. Most commonly, the pairs of nucleic bases A=T and G≡C are formed, of which the latter is more stable. DNA denaturation, also called DNA melting, is the process by which double-stranded deoxyribonucleic
A Is for Acid A Is for Acid A Is for Acid is a 2002 British television film based on the life of the serial killer John George Haigh, known as the Acid Bath Murderer, because he dissolved the bodies of six people in sulphuric acid. Haigh, hanged in 1949 for his crimes, had wrongly believed that murder could not be proven without the presence of a body. Starring Martin Clunes in the lead role, the film was shot in Scarborough, chosen because its appearance was believed similar to that of London when Haigh lived there during the 1940s. The film was produced by