Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
1837 Great Plains smallpox epidemic the epidemic these groups were never able to recover. Ethnic backgrounds also merged as survivors from different communities joined together. As some communities such as the Saulteaux were able to take advantage of vaccination efforts by the HBC they also took advantage of struggling Indigenous groups. The HBC vaccination efforts were focused on populations that produced furs. As result, the Plains Cree and Saulteaux pushed out its borders as others retreated during the epidemic. There have been many documented cases of smallpox being intentionally spread among the indigenous people of the Americas by colonizers. As observed by academic researchers in