Single-use bioreactor providing a family of single-use bioreactors from bench-top to full-scale production. Three challenges exist for faster and greater single use bioreactor adoption 1) higher quality and lower cost disposable bags and containers, 2) more reusable and disposable sensors and probes that can provide high quality analytics including real-time cell culture level data points, and 3) a family of bioreactors from lab to production that has full scale-up of the bioprocess. Suppliers are working to improve plastic bag materials and performance and also to develop a broader range of sensors and probes that provide scientists greater insight to cell density, quality
Single-use bioreactor primarily upstream equipment www.millipore.com, GE Healthcare Life Sciences with its WAVE brand rocking, single-use bioreactor and Thermo Scientific www.thermo.com with its traditional stirred or impeller shaft based mixing approach does also have some of this technologies available. Only Sartorius Stedim, PBS Biotech, Thermo Fisher Hyclone, and Xcellerex (now part of GE Healthcare Life Sciences) have the ability to provide a fully scalable solution for a complete lab-to-production bioprocess. The BioProcess Systems Alliance (BPSA) is the single use association advocating broader application of single-use to include cGMP Good manufacturing practice use which will require FDA support. The agency has stated in