Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Henry Berkeley, 7th Baron Berkeley The 6th Baron had earlier been married to Mary Hastings, the daughter of George Hastings, 1st Earl of Huntingdon, by Anne Stafford (d. March 1533), daughter of Henry Stafford, 2nd Duke of Buckingham, but had no issue by her. Berkeley was made a Knight of the Bath on 28 September 1553 at the coronation of Mary I. In the following year, Berkeley Castle and other estates were restored to him when the line of male heirs of Henry VII was extinguished. As Simon Adams points out, "in 1487 William, Marquis Berkeley, had granted Berkeley Castle and its related manors to