Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Berkeley, Gloucestershire 824 as "Berclea", from the Old English for "birch lea". Berkeley was a significant place in medieval times. It was a port and market-town, and the meeting place of the hundred of Berkeley. After the Norman Conquest, a Flemish noble named Roger de Tosny was appointed Provost of the manor of Berkeley by his brother-in-law (or perhaps uncle) Earl William FitzOsbern. His family took the name "de Berkeley", and it was he who began the construction of Berkeley Castle, which was completed by his son, also Roger. A younger son of the elder Roger, John de Berkeley, went north to