Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Castle Hill, Mere the hill. At the same time the village was expanded into a planned town with an unofficial market. The castle was renovated in 1300, possibly in response to the threat of rebellion in England at the time. Richard's son Edmund inherited the property, but on his death it was taken back by the Crown. Edward II gave it to his royal favourite, Piers Gaveston, whom he made Earl of Cornwall. Edward II and Gaveston fell from power in 1327 and John, Edward's second son, took possession as the new Earl of Cornwall. Edward III then reacquired the castle, which became