Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Frederick Augustus Berkeley, 5th Earl of Berkeley Berkeley once had on the road:He had always declared that any one might without disgrace be overcome by superior numbers, but that he would never surrender to a single highwayman. As he was crossing Hounslow Heath one night, on his way from Berkeley Castle to London, his travelling carriage was stopped by a man on horseback, who put his head in at the window and said, ‘I believe you are Lord Berkeley?’ ‘I am.’ ‘I believe you have always boasted that you would never surrender to a single highwayman?’ ‘I have.’ ‘Well,’ presenting a pistol, ‘I am a single highwayman,