Smallpox one-third of the cases resulted in blindness. These deaths included those of four reigning monarchs and a queen consort. In the 20th century smallpox killed 200-300 million people. Edward Jenner discovered in 1798 that vaccination could prevent smallpox. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest in 2011. The term "smallpox" was first used in Britain in the 15th century to distinguish the disease from syphilis, which was then known as the "great pox". Other historical names for the disease include pox, speckled
Smallpox vaccine in Koltsovo, Russia. These states report that their repositories are for possible antibioweaponry research and insurance if some obscure reservoir of natural smallpox is discovered in the future. The word "vaccine" is derived from "Variolae vaccinae" (i.e. smallpox of the cow), the term devised by Jenner to denote cowpox and used in the long title of his "An enquiry into the causes and effects of Variolae vaccinae, known by the name of cow pox". Vaccination, the term which soon replaced "cowpox inoculation" and "vaccine inoculation", was first used in print by Jenner's friend, Richard Dunning in 1800. Initially, the terms