Smallpox 1718. In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. In 1796, Edward Jenner, a doctor in Berkeley, Gloucestershire, rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine, from the root word "vacca", which is Latin for cow. The procedure was much safer than variolation, and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox was soon practiced all over the world. During the
Vaccination and religion missionaries vaccinated Northwest Coast Native Americans during an 1862 smallpox epidemic. In the UK, a number of Vaccination Acts were introduced to control vaccination and inoculation, starting in 1840, when smallpox inoculation was banned. The 1853 Act introduced compulsory free infant vaccination enforced by local authorities. By 1871, infant vaccination was compulsory and parents refusing to have their child vaccinated were fined and imprisoned if the fines were not paid. Resistance to compulsion grew, and in 1889, after riots in Leicester, a Royal Commission was appointed and issued six reports between 1892 and 1896. It recommended the abolition of cumulative