Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Thomas de Berkeley, 5th Baron Berkeley including in 1395 when he served jointly with Gilbert Denys. Nigel Saul states that such feoffees were likely to have been members of Lord Berkeley's retinue. These were very significant positions of trust granted to his feoffees as Berkeley died leaving only a daughter and the succession to the vast Berkeley lands, including the castle itself, became a matter of much dispute amongst his possible heirs resulting in a series of feuds which led in 1470 to the last private battle fought on English soil at the Battle of Nibley Green, between Lord William Berkeley and Viscount Lisle, and there