Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
1837 Great Plains smallpox epidemic were critical to limiting the spread of smallpox in Canada. After the epidemic the HBC implemented a territory wide vaccination program which further reduced smallpox deaths. Unfortunately, as people entered communities with the intention of vaccinating against smallpox, they brought with them additional diseases that worked to keep mortality rates high. The epidemic would alter power structures of impacted nations. As the Assinboine and Niitsitapi did not get the opportunity for vaccination and as a result both their populations and territory shrunk considerably. The disease was particularly deadly among these people because of the denser populations. After being hit by