Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
1837 Great Plains smallpox epidemic vaccination attempts to stop the spread of smallpox at the onset of the epidemic. The first by the American Fur Company was largely unsuccessful. Many traders tried to obtain vaccines but the AFC was unwilling to heed their requests. The second was by the American government. Here efforts were made under the Indian Vaccination Act of 1832. Some areas did receive vaccines for smallpox, typically ones that were in contact with Americans, usually in the southern United States. Still the Office of Indian Affairs did not have the network or information needed to vaccinate the plains people quickly, nor did