Anthony Tupou the 2008 Rugby League World Cup. He was named in the Australia squad for the 2008 Rugby League World Cup, replacing Michael Crocker who withdrew through injury. Although also named in the Tonga training squad for the 2008 Rugby League World Cup, Tupou played for Australia. Tupou played for the Sharks mainly at second-row forward. Tupou was named in NSW's preliminary 40 man squad for the 2009 State of Origin series. He was selected for Country in the City vs Country match on 8 May 2009. In 2013, Tupou played for the Tonga national rugby league team in their Pacific
Anthony Tupou Rugby League International clash with fierce rivals Samoa. On 22 August 2014, Tupou became one of the current Sharks players to accept reduced bans from the Australian Sports Anti-Doping Authority for his role in the club's 2011 supplements scandal. On 2 November 2015, Tupou signed a 2-year contract with Super League side Wakefield Trinity Wildcats starting in 2016. In 2017, Tupou returned to his hometown to play for the Newcastle Knights on a 1-year contract. He made his Knights début in round 5 of the 2017 season against his former club Cronulla. With a hip injury limiting his time at