Tame Tupou to his Bulls career by scoring 10 tries in 11 games that season. At the end of that year Tupou was selected for New Zealand's 2007 All Golds tour of Great Britain. Tupou made a poor start in 2008 due to knee injuries, starting in three games and coming on as a substitute in others. In August that year he was named in the Tonga training squad for the 2008 Rugby League World Cup but was not selected in the final squad after he had to undergo another knee reconstruction. In April 2009 Bradford released Tupou after a Rugby Football
Christian Tupou agent in 2012. Tupou received his first NFL start in the preseason against the Cleveland Browns and recorded a sack. He was released in 2013. Tupou was signed to the practice squad on January 3, 2014. Tupou was signed to 49ers roster on January 22, 2014. Tupou was released by the 49ers to make room for Josh Johnson on May 14, 2014. Tupou signed with the Arizona Cardinals in May 2014. The Cardinals released Tupou on August 30, 2014, but he shortly re-signed to their practice squad. Tupou was signed to the Cleveland Browns practice squad on October 17, 2014.