Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Maurice de Berkeley, 2nd Baron Berkeley his wife he had children including: His second marriage, in about 1316, was to Isabella de Clare, daughter of Gilbert de Clare, 6th Earl of Hertford by his wife Alice de Lusignan. Berkeley was imprisoned by the Despencers in Wallingford Castle in Berkshire (now in Oxfordshire), where he died on 31 May 1326 and was eventually buried in St Augustine's Abbey (now Bristol Cathedral) in Bristol, founded by his ancestor. He was succeeded by his eldest son Thomas de Berkeley, 3rd Baron Berkeley (born c. 1296). Maurice de Berkeley, 2nd Baron Berkeley Maurice de Berkeley, 2nd Baron Berkeley (April 1271