Members of the western concert flute family the instrument is a prototype built for Italian flautist Roberto Fabbriciani by Francesco Romei, a Florentine craftsman. Members of the western concert flute family The western concert flute family has a wide range of instruments. The piccolo is the highest-pitched member of the flute family, with a range an octave above that of the concert flute. It is usually the highest-pitched instrument within orchestras and bands. The piccolo has a stereotype for being difficult to play in tune; its small size makes it difficult to construct an evenly tuned scale. The treble flute is pitched in the key of G,
Shroom family member 2 gene. [provided by RefSeq, Mar 2016]. Shroom family member 2 Shroom family member 2 is a protein that in humans is encoded by the SHROOM2 gene. This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript