Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Berkeley family Berkeley and of Robert Fitzharding either adopted, or continued the use of, the surname "de Berkeley", the former retaining the truncated feudal barony of Dursley, the latter establishing his line as feudal barons of Berkeley Castle. Both lines of Berkeleys therefore originated as cousins, but it was the line of the feudal barons of Berkeley, descended from Fitzharding in the male line, which was by far the more powerful and which would play the more prominent role in British history in the next several centuries. The Scottish Clan Barclay may or may not be descended from the family; however, the