Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
James Berkeley, 1st Baron Berkeley cousin Elizabeth, daughter of the fifth Baron Berkeley and wife of Richard de Beauchamp, 13th Earl of Warwick. He was unable initially to claim Berkeley Castle, as it was taken in possession by the Earl and Countess of Warwick. In 1421, when the Warwicks finally gave up Berkeley Castle, James was summoned to Parliament by writ as Lord Berkeley. The feud did not end there as his third wife Isabel was captured by the Countess of Warwick's son-in-law the Earl of Shrewsbury, and held imprisoned until her death in 1452. Lord Berkeley was succeeded by his son from his third