Anthrax vaccines known to result in far less scarring, and greatly reduced mortality, in comparison with the naturally acquired disease. The English physician Edward Jenner (1749–1823) had also discovered (1796) the process of vaccination by using cowpox to give cross-immunity to smallpox and by Pasteur's time this had generally replaced the use of actual smallpox material in inoculation. The difference between smallpox vaccination and anthrax or chicken cholera vaccination was that the weakened form of the latter two disease organisms had been "generated artificially", so a naturally weak form of the disease organism did not need to be found. This discovery revolutionized
1972 Yugoslav smallpox outbreak 1972 Yugoslav smallpox outbreak The 1972 Yugoslav smallpox outbreak was the last major outbreak of smallpox in Europe. It was centred in Kosovo and Belgrade (both then part of the Socialist Federal Republic of Yugoslavia). A Muslim pilgrim had contracted the smallpox virus in the Middle East. Upon returning to his home in Kosovo, he started the epidemic in which 175 people were infected, 35 of whom died. The epidemic was efficiently contained by enforced quarantine and mass vaccination. The 1982 film "Variola Vera" is based on the event. By 1972, vaccination for smallpox had long been widely available and