Smallpox vaccine Smallpox vaccine Smallpox vaccine, the first successful vaccine to be developed, was introduced by Edward Jenner in 1796. He followed up his observation that milkmaids who had previously caught cowpox did not later catch smallpox by showing that inoculated cowpox protected against inoculated smallpox. Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been
1837 Great Plains smallpox epidemic Early vaccination efforts by the Hudson's Bay Company were sporadic and unorganized during its monopoly period. Although the HBC recognized the potential of vaccination, understanding that more people ment more fur for them, there was no systematic vaccination program in place until the epidemic was well underway. Some vaccines were sent to trading posts early in the 19th Century but were left to collect dust. The smallpox infection spiked in 1780s, as persisted up to the 1837 epidemic. In what is now Canada, fur trade strengthened communities such as the Mushego Cree, Anishinabe, and Ottawa. The Mandan tribe had previously