Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Berkeley Castle around 1067 by William FitzOsbern shortly after the Conquest. This was subsequently held by three generations of the first Berkeley family, all called Roger de Berkeley, and rebuilt by them in the first half of the 12th century. The last Roger de Berkeley was dispossessed in 1152 for withholding his allegiance from the House of Plantagenet during the conflict of The Anarchy, and the feudal barony of Berkeley was then granted to Robert Fitzharding, a wealthy burgess of Bristol and supporter of the Plantagenets. He was the founder of the Berkeley family which still holds the castle. In 1153–54, Fitzharding