Single-handed sailing circumnavigation, as it was contained within the southern hemisphere; however, he made the first single-handed passage of the three great capes, and indeed the first successful single-handed passage of Cape Horn. With only three landfalls, Vito Dumas described the legs of his trip as the longest that had been made by a single-hander, and in the most ferocious oceans on the Earth. Organised single-handed yacht racing was pioneered by Britons "Blondie" Hasler and Francis Chichester, who conceived the idea of a single-handed race across the Atlantic Ocean. This was a revolutionary concept at the time, as the idea was thought
Single-use bioreactor and other metrics needed to improve yields and product efficacy. New perfusion devices are also becoming popular for certain cell culture applications. Environmental aspects for single-use bioreactors are important to consider due to the amount of disposable material used compared with conventional bioreactors. A complete life cycle assessment comparing single-use bioreactors and conventional bioreactors does not exist, but many ecological reasons are supporting the concept of single-use bioreactors. For a complete life cycle assessment not only the manufacturing, but also the repeated use need to be considered. Even the main part of a single-use bioreactor is not a disposable, but