Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Berkeley Castle before returning him to Berkeley Castle in September. Some commentators have claimed that Edward's escape was actually successful, and that someone else was later murdered in his place. Historical sources record that Edward was murdered there on 21 September 1327. Raphael Holinshed's "Chronicles" (1587 edition), drawing on earlier sources, describes Edward's murder in detail:they [the murderers] came suddenlie one night into the chamber where he laie in bed fast asléepe, and with heauie featherbeds or a table (as some [sources] write) being cast vpon him, they kept him down and withall put into his fundament [i.e., his anus] an horne,