Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Baron Berkeley Berkeley" held extensive lands in-chief of the king in 1086, as recorded by Domesday Book, including Dursley and retired as a monk to St Peter's Abbey, Gloucester in about 1091. His son Roger II (d. about 1131) and grandson Roger III (d. after 1177) also held the manor of Dursley in-chief of the king. In 1152 Roger III was deprived of the farm of Berkeley during the civil war between King Stephen and the Empress Maud. He was later restored to Dursley, and founded the family of "Berkeley of Dursley", but Berkeley Castle was granted by barony to Robert FitzHarding,