Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Berkeley family docent and genealogist at the Berkeley Castle listed the Barclay clan as also descending from the de Berkeley clan through the matriarchal line Alice De Berkeley -- the woman who married Robert Fitzharding and restored the family's name. Additionally, historians on Scottish clans and surnames point out that the Barclay clan spelling moves into the Berkeley (pronounced Bar-Clay) spelling. This descends from Sir Maurice Berkeley (by 1514–81), a politician who rose rapidly in the Tudor court. He came from the Berkeleys of Stoke Gifford, a cadet branch of the main Berkeley family, as a descendant of Sir Maurice de Berkeley