Vaccination disease people tried to prevent by inoculation and was the first disease for which a vaccine was produced. The smallpox vaccine was invented in 1796 by English physician Edward Jenner and although at least six people had used the same principles years earlier he was the first to publish evidence that it was effective and to provide advice on its production. Louis Pasteur furthered the concept through his work in microbiology. The immunization was called "vaccination" because it was derived from a virus affecting cows ( 'cow'). Smallpox was a contagious and deadly disease, causing the deaths of 20–60% of
Vaccination the English ambassador at Istanbul between 1716 and 1718, who almost died from smallpox as a young adult and was physically scarred from it. Inoculation was adopted both in England and in America nearly half a century before Jenner's famous smallpox vaccine of 1796 but the death rate of about 2% from this method meant that it was mainly used during dangerous outbreaks of the disease and remained controversial. It was noticed during the 18th century that people who had suffered from the less virulent cowpox were immune to smallpox, and the first recorded use of this idea was by