History of smallpox In the late 1770s, during the American Revolutionary War, smallpox returned once more and killed thousands. Peter Kalm in his "Travels in North America", described how in that period, the dying Indian villages became overrun with wolves feasting on the corpses and weakened survivors. Smallpox was also used as a weapon by the British. In 1799, the physician Valentine Seaman administered the first smallpox vaccine in the United States. He gave his children a smallpox vaccination using a serum acquired from Edward Jenner, the British physician who invented the vaccine from fluid taken from cowpox lesions. Though vaccines were misunderstood
Smallpox years before exposure was 1.3 percent; it was 7 percent among those vaccinated 11 to 20 years prior, and 11 percent among those vaccinated 20 or more years prior to infection. By contrast, 52 percent of unvaccinated persons died. There are side effects and risks associated with the smallpox vaccine. In the past, about 1 out of 1,000 people vaccinated for the first time experienced serious, but non-life-threatening, reactions, including toxic or allergic reaction at the site of the vaccination (erythema multiforme), spread of the vaccinia virus to other parts of the body, and to other individuals. Potentially life-threatening reactions