Shakespeare at the Tobacco Factory which, after a spring run in Bristol, transferred to the Barbican Centre in London for a five-week run in the autumn. In May 2004 the company was reborn as a charity as it now continues, named Shakespeare at the Tobacco Factory 2004 Limited. This new status allowed charitable donations and an element of subsidy to be sought. In subsequent years the company has produced many more Shakespeare plays, as well as Anton Chekhov's "The Cherry Orchard" and "Uncle Vanya", and Molière's "The Misanthrope". Jonathan Miller was guest director for a 2008 production of "Hamlet". Polinina Kalinina joined the company as
Vanya and Sonia and Masha and Spike Nielsen and Liesel Allen Yaeger. In September/October 2013, a separate production ran in the Phoenix Theatre, Indianapolis, produced by Bryan Fonseca. In 2014, the show ran at the Guthrie Theater in Minneapolis, and in Tucson and Phoenix, Arizona. The show was produced in Seattle at the ACT Theatre from October 17 – November 16, 2014. Playwright Durang starred as Vanya alongside Marilu Henner as Masha in a production at the Bucks County Playhouse from July 17 to August 10, 2014. Although "Vanya and Sonia and Masha and Spike" is a comedy, it has some darker elements that pervade its themes.