Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Thomas de Berkeley, 5th Baron Berkeley to that of his contemporary Sir Maurice Russell (d.1416) at Dyrham, who was the father-in-law of Gilbert Denys, one of Berkeley's feoffees. Having died without male progeny the succession to the vast Berkeley estates became disputed, and eventually resulted in the Battle of Nibley Green (1469/70), the last battle fought in England entirely between the private armies of feudal magnates, fought near Berkeley Castle on 20 March 1469/70 between the troops of Thomas Talbot, 2nd Viscount Lisle and William Berkeley, 2nd Baron Berkeley, later 1st Marquess of Berkeley. Lisle and William Berkeley had long been engaged in a dispute over