Smallpox one-third of the cases resulted in blindness. These deaths included those of four reigning monarchs and a queen consort. In the 20th century smallpox killed 200-300 million people. Edward Jenner discovered in 1798 that vaccination could prevent smallpox. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest in 2011. The term "smallpox" was first used in Britain in the 15th century to distinguish the disease from syphilis, which was then known as the "great pox". Other historical names for the disease include pox, speckled
1837 Great Plains smallpox epidemic vaccination attempts to stop the spread of smallpox at the onset of the epidemic. The first by the American Fur Company was largely unsuccessful. Many traders tried to obtain vaccines but the AFC was unwilling to heed their requests. The second was by the American government. Here efforts were made under the Indian Vaccination Act of 1832. Some areas did receive vaccines for smallpox, typically ones that were in contact with Americans, usually in the southern United States. Still the Office of Indian Affairs did not have the network or information needed to vaccinate the plains people quickly, nor did