Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
England in the Late Middle Ages English heir in her power, Isabella refused to return to England unless Edward II dismissed his favourites and also formed a relationship with Roger Mortimer, 1st Earl of March. The couple invaded England and, joined by Henry, 3rd Earl of Lancaster, captured the king. Edward II abdicated on the condition that his son would inherit the throne rather than Mortimer. He is generally believed to have been murdered at Berkeley Castle by having a red-hot poker thrust into his bowels. In 1330 a coup by Edward III ended four years of control by Isabella and Mortimer. Mortimer was executed, but