Mozart and smallpox the imperial family were successful, and led to greater public acceptance for the procedure. Smallpox struck the Mozart family again in the next generation: Nannerl's eldest son Leopold and two of her stepchildren caught the disease during an outbreak in the Salzburg area in 1787. All three children survived. In 1796, the discovery of vaccination—the use of the related cowpox virus to immunize against smallpox—by Edward Jenner revolutionized the ability of medicine to deal with smallpox. Vaccination reached Vienna around 1800, when yet another local epidemic created impetus for its adoption. One of the doctors trained in the Vienna campaign,
1837 Great Plains smallpox epidemic Early vaccination efforts by the Hudson's Bay Company were sporadic and unorganized during its monopoly period. Although the HBC recognized the potential of vaccination, understanding that more people ment more fur for them, there was no systematic vaccination program in place until the epidemic was well underway. Some vaccines were sent to trading posts early in the 19th Century but were left to collect dust. The smallpox infection spiked in 1780s, as persisted up to the 1837 epidemic. In what is now Canada, fur trade strengthened communities such as the Mushego Cree, Anishinabe, and Ottawa. The Mandan tribe had previously