Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Baron Berkeley was created Viscount Berkeley in 1481, Earl of Nottingham in 1483, and Marquess of Berkeley in 1488. He had no surviving male issue, so the Marquessate and his other non-inherited titles became extinct on his death in 1491, whilst the barony passed "de jure" to his younger brother Maurice. However William had disinherited Maurice because he considered him to have brought shame on the noble House of Berkeley by marrying beneath his status to Isabel, daughter of Philip Mead of Wraxhall, an Alderman and Mayor of Bristol. Instead he bequeathed the castle, lands and lordships comprising the Barony of Berkeley