Anthony Tupou the 2008 Rugby League World Cup. He was named in the Australia squad for the 2008 Rugby League World Cup, replacing Michael Crocker who withdrew through injury. Although also named in the Tonga training squad for the 2008 Rugby League World Cup, Tupou played for Australia. Tupou played for the Sharks mainly at second-row forward. Tupou was named in NSW's preliminary 40 man squad for the 2009 State of Origin series. He was selected for Country in the City vs Country match on 8 May 2009. In 2013, Tupou played for the Tonga national rugby league team in their Pacific
Christian Tupou agent in 2012. Tupou received his first NFL start in the preseason against the Cleveland Browns and recorded a sack. He was released in 2013. Tupou was signed to the practice squad on January 3, 2014. Tupou was signed to 49ers roster on January 22, 2014. Tupou was released by the 49ers to make room for Josh Johnson on May 14, 2014. Tupou signed with the Arizona Cardinals in May 2014. The Cardinals released Tupou on August 30, 2014, but he shortly re-signed to their practice squad. Tupou was signed to the Cleveland Browns practice squad on October 17, 2014.