Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Berkhamsted Castle the growing wool trade. Richard died at the castle in 1272, and it passed to his son Edmund. The castle passed on through Edward I, who found the castle in an apparently poor condition, and his second wife, Margaret, to Edward II. Edward II gave it to his royal favourite, Piers Gaveston, whom he made Earl of Cornwall. Gaveston was married there in 1307, with Edward in attendance. Edward II and Gaveston fell from power in 1327 and John, Edward's second son, took possession as the new Earl of Cornwall. When John died, Edward III reclaimed Berkhamsted Castle; a survey