Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Margaret Mortimer, Baroness Berkeley Margaret Mortimer, Baroness Berkeley Margaret Mortimer, Baroness Berkeley (2 May 1304 – 5 May 1337) was the wife of Thomas de Berkeley, 3rd Baron Berkeley. She was the eldest daughter of Roger Mortimer, 1st Earl of March, the "de facto" ruler of England from 1327 to 1330, and his wife Joan de Geneville, Baroness Geneville. Margaret Mortimer was the eldest of the twelve children of Roger Mortimer, 1st Earl of March and Joan de Geneville, Baroness Geneville. Her paternal grandparents were Edmund Mortimer, 2nd Baron Mortimer and Margaret de Fiennes. Her maternal grandparents were Piers de Geneville, of Trim Castle