Smallpox one-third of the cases resulted in blindness. These deaths included those of four reigning monarchs and a queen consort. In the 20th century smallpox killed 200-300 million people. Edward Jenner discovered in 1798 that vaccination could prevent smallpox. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest in 2011. The term "smallpox" was first used in Britain in the 15th century to distinguish the disease from syphilis, which was then known as the "great pox". Other historical names for the disease include pox, speckled
1947 New York City smallpox outbreak stated that they had other diseases of the central nervous system and none had encephalitis. Three deaths were clearly related to other complications of the vaccine—a 66-year-old man who developed sepsis from an infected vaccination site, and two infants with eczema who developed generalized vaccinia after contact with others who had been vaccinated. Two additional victims who received the smallpox vaccine and died were named in newspaper reports—Benjamin F. Cohen, age 41, of Newark, N.J., who died on May 5, a little more than two weeks after being vaccinated, and Nancy Jean Vanderhoof, age 3, of New Providence, N.J., who