Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Kenilworth Castle of the Midlands, in an area that held several nobles who still supported Edward and were believed to be trying to rescue him. Henry's loyalty was also coming under question. In due course, Isabella and Mortimer had Edward moved by night to Berkeley Castle, where he died shortly afterwards. Isabella continued to use Kenilworth as a royal castle until her fall from power in 1330. Henry of Grosmont, the Duke of Lancaster, inherited the castle from his father in 1345 and remodelled the great hall with a grander interior and roof. On his death Blanche of Lancaster inherited the castle.