Berkeley, Gloucestershire Berkeley, Gloucestershire Berkeley ( ) is a small town and parish in Gloucestershire, England. It lies in the Vale of Berkeley between the east bank of the River Severn and the M5 motorway, within the Stroud administrative district. The town is noted for Berkeley Castle, where the imprisoned Edward II was murdered, as well as the birthplace of the physician Edward Jenner, pioneer of the smallpox vaccine, the world's first vaccine. The parish also includes the village of Berkeley Heath, which runs along the A38 Bristol to Gloucester road and the adjacent B4066 towards Berkeley. Berkeley lies midway between Bristol
Berkeley Castle Hugh Despenser, the favourite of Edward II. Then in 1327, Edward was deposed by his wife Queen Isabella and her ally Roger Mortimer, and placed in the joint custody of Mortimer’s son-in-law, Thomas de Berkeley, and de Berkeley‘s brother-in-law, John Maltravers. They brought Edward to Berkeley Castle, and held him there for five months from April to September. During that time a band of Edward's supporters attacked, entered the castle and rescued him, only for him to be recaptured soon afterwards. It is possible that his captors then moved him around between several castles to make further rescue more difficult,