Nobel Prize controversies works there were available only in samizdat-published, clandestine form. After the Swedish government refused to hold a public award ceremony and lecture at its Moscow embassy, Solzhenitsyn refused the award altogether, commenting that the conditions set by the Swedes (who preferred a private ceremony) were "an insult to the Nobel Prize itself." Solzhenitsyn later accepted the award on 10 December 1974, after the Soviet Union banished him. Critics suggest that Solzhenitsyn was awarded the prize because of his political stance, not his writing. Leo Tolstoy was nominated for the two first-ever Nobel Prizes in Literature. In the first year, the
Nobel Prize in Physiology or Medicine award. The front side of the medal displays the same profile of Alfred Nobel depicted on the medals for Physics, Chemistry, and Literature. The reverse side is unique to this medal. The most recent Nobel prize was announced by Karolinska Institute on 1 October 2018, and has been awarded to American James P. Allison and Japanese Tasuku Honjo – for their discovery of cancer therapy by inhibition of negative immune regulation. As of 2015, 106 Nobel Prizes in Physiology or Medicine have been awarded to 198 men and 12 women. The first one was awarded in 1901 to the German