Tame Tupou to his Bulls career by scoring 10 tries in 11 games that season. At the end of that year Tupou was selected for New Zealand's 2007 All Golds tour of Great Britain. Tupou made a poor start in 2008 due to knee injuries, starting in three games and coming on as a substitute in others. In August that year he was named in the Tonga training squad for the 2008 Rugby League World Cup but was not selected in the final squad after he had to undergo another knee reconstruction. In April 2009 Bradford released Tupou after a Rugby Football
Anthony Tupou Rugby League International clash with fierce rivals Samoa. On 22 August 2014, Tupou became one of the current Sharks players to accept reduced bans from the Australian Sports Anti-Doping Authority for his role in the club's 2011 supplements scandal. On 2 November 2015, Tupou signed a 2-year contract with Super League side Wakefield Trinity Wildcats starting in 2016. In 2017, Tupou returned to his hometown to play for the Newcastle Knights on a 1-year contract. He made his Knights début in round 5 of the 2017 season against his former club Cronulla. With a hip injury limiting his time at