Single-use bioreactor providing a family of single-use bioreactors from bench-top to full-scale production. Three challenges exist for faster and greater single use bioreactor adoption 1) higher quality and lower cost disposable bags and containers, 2) more reusable and disposable sensors and probes that can provide high quality analytics including real-time cell culture level data points, and 3) a family of bioreactors from lab to production that has full scale-up of the bioprocess. Suppliers are working to improve plastic bag materials and performance and also to develop a broader range of sensors and probes that provide scientists greater insight to cell density, quality
Single-use bioreactor the pH, and the color, of the dye. The color change can be detected with a laser external to the bag. This and other methods of non-invasive measurement have been developed for single-use bioreactors. Single-use process steps available are: media and buffer preparation, cell harvesting, filtration, purification and virus inactivation. Other manufacturers include Cellexus with their CellMaker with an air lift system for bacterial production,PBS Biotech, Inc. with its novel Air-Wheel mixing mechanism and low shear and scalability from lab to cGMP (Good manufacturing practice) production and is fully integrated, easy to use www.pbsbiotech.com as well as Millipore, which is