Insulin effect of increasing glucose uptake and storage. Finally, insulin is degraded, terminating the response. In mammals, insulin is synthesized in the pancreas within the beta cells. One million to three million pancreatic islets form the endocrine part of the pancreas, which is primarily an exocrine gland. The endocrine portion accounts for only 2% of the total mass of the pancreas. Within the pancreatic islets, beta cells constitute 65–80% of all the cells. Insulin consists of two polypeptide chains, the A- and B- chains, linked together by disulfide bonds. It is however first synthesized as a single polypeptide called preproinsulin in
Violet gland dog's violet gland tends to fall out when androgen levels are high over a prolonged time. In short-haired breeds the usually inconspicuous gland may thus appear as a noticeably sparsely haired patch, and it is this condition of the gland area that is most frequent in stud dogs. In foxes, the violet gland is found on the upper surface of the tail, at roughly one-third of the tail's length from the body, and measures about 25 by 7.5 millimeters in red foxes. Due to its role in steroid hormone metabolism (and possibly production), foxes cannot be "de-scented" by removing this