John Gough (natural philosopher) wife and seven of their children. He was buried in the parish churchyard of Kendal. Gough had wide-ranging scientific interests. He published papers in natural history, mechanics, mathematics, chemistry, and experimental physics. One of his most interesting pieces of work was an investigation into the properties of natural rubber or Caoutchouc. He was the first to describe the heat released when a rubber band is quickly stretched, the heat being detected by the lips to which the band is pressed. When stretched rubber is heated, it contracts, a reversal of the normal behaviour of materials when heated. Gough published these
Substance dependence Substance dependence Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use. A "drug addiction", a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An "addictive drug" is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral addiction and drug addictions, but not dependence. Within the framework of the 4th edition of