Natural product to modern discovery of their active ingredients and eventually to the development of new drugs. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. A few representative examples are listed below. Some of the oldest natural product based drugs are analgesics. The bark of the willow tree has been known from antiquity to have pain relieving properties. This is due to presence of the natural product salicin which in turn may be hydrolyzed into salicylic acid. A synthetic derivative acetylsalicylic acid better known as aspirin is a widely used pain reliever.
Birch bark manuscript In Indian sculpture, a Birch bark manuscript is easily identified by the droop. A palm leaf manuscript is stiff. On July 26, 1951, during excavations in Novgorod, a Soviet expedition led by Artemiy Artsikhovsky found the first Russian birch bark writing in a layer dated to c. 1400. Since then, more than 1,000 similar documents were discovered in Staraya Russa, Smolensk, Torzhok, Pskov, Tver, Moscow, Ryazan, and Vologda, although Novgorod remains by far the most prolific source of them. In Ukraine, birch bark documents were found in Zvenyhorod, Volynia. In Belarus, several documents were unearthed in Vitebsk and Mstislavl. The