History of aspirin mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it.
A. C. and Mamie Forehand A. C. and Mamie Forehand A. C. (also, "Asey" or "Asa") Forehand and (Blind) Mamie Forehand were husband and wife American gospel musicians. They recorded four songs for Victor Records in 1927. A. C. is credited with the two songs recorded on February 25, and Mamie with the two recorded on February 28according to which one of them sang, but both played on all four: A. C. guitar and harmonica, Mamie an instrument variously identified as triangle or finger cymbals. A. C. was born in Columbus, Georgia on August 9, 1890 (according to his second wife, Frances) or 1893 (according