History of aspirin History of aspirin The history of aspirin (IUPAC name acetylsalicylic acid ) begins with its synthesis and manufacture in 1899. Before that, salicylic acid had been used medicinally since antiquity. Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to their use of salicylic tea to reduce fevers around 400 BC, and were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. Willow bark extract became recognized for its specific effects on fever, pain and inflammation in the
Tetrolic acid (water, ethanol) and may be recrystallized from non polar solvents (such as heptane, toluene). The compound is a white crystalline solid which can exist in two polymorphous crystalline forms. The proton nuclear magnetic resonance (H-NMR) spectrum in deuterated dimethyl sulfoxide shows a characteristic singlet peak at 1.99 ppm corresponding to the -CH protons. Tetrolic acid Tetrolic acid (2-butynoic acid) is a short-chain unsaturated carboxylic acid, described by the formula CH-C≡C-COH. Salts and esters of tetrolic acid are known as tetrolates. The first reported synthesis of tetrolic acid is believed to be by German chemist Johann Georg Anton Geuther in 1871