Adult-onset Still's disease Adult-onset Still's disease Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. The disease is considered a diagnosis of exclusion. Levels of the iron-binding protein ferritin may be extremely elevated with this disorder. AOSD may present in a similar manner to other inflammatory diseases and to autoimmune diseases, which must be ruled out before making the diagnosis. Prognosis is usually favorable but manifestations of the disease affecting the lungs, heart, or kidneys may occasionally cause severe
Effect of spaceflight on the human body changes included a flattening of the eyeball and changes to the retina. Space traveler's eye-sight can become blurry after too much time in space. Another effect is known as Cosmic ray visual phenomena Because weightlessness increases the amount of fluid in the upper part of the body, astronauts experience increased intracranial pressure. This appears to increase pressure on the backs of the eyeballs, affecting their shape and slightly crushing the optic nerve. This effect was noticed in 2012 in a study using MRI scans of astronauts who had returned to Earth following at least one month in space. Such eyesight