Adult-onset Still's disease Adult-onset Still's disease Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. The disease is considered a diagnosis of exclusion. Levels of the iron-binding protein ferritin may be extremely elevated with this disorder. AOSD may present in a similar manner to other inflammatory diseases and to autoimmune diseases, which must be ruled out before making the diagnosis. Prognosis is usually favorable but manifestations of the disease affecting the lungs, heart, or kidneys may occasionally cause severe
Signs and symptoms of Graves' disease a high prevalence of neuropsychiatric disorders and mental disorder symptoms in Graves' disease (and thyroid disease in general), which are similar to those in patients with organic brain disease. These manifestations are diverse, affecting the central and peripheral nervous systems. The vast majority of patients with hyperthyroidism meet criteria for some psychiatric disorders, and those with milder presentations are probably not entirely free of mental symptoms such as emotional lability, tension, depression and anxiety. Anxiety syndromes related to hyperthyroidism are typically complicated by major depression and cognitive decline, such as in memory and attention. Some studies contradict the psychological findings.