Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
Willow flute tempered scale. Modern willow flutes are typically made of plastic (PVC tubing is often used), but the original willow flutes were made from sections of bark cut from green willow branches. Willow flutes could only be made this way during the spring, and became unplayable when the bark dried out. Noted modern willow flute artists include the group Hedningarna and Anders Norudde of Sweden. Other Scandinavian groups that use the Seljefløyte in traditional arrangements include Eivind Groven, Steinar Ofsdal, Groupa and Bask. There is also a Karelian variant of the willow flute that is made in Finnish Karelia and the