Insulin (medication) testing and occasionally skin biopsy. First line therapy against insulin hypersensitivity reactions include symptomatic therapy with antihistamines. The affected persons are then switched to a preparation that does not contain the specific agent they are reacting to or undergo desensitization. Insulin is an endogenous hormone, which is produced by the pancreas. The insulin protein has been highly conserved across evolutionary time, and is present in both mammals and invertebrates. The insulin/insulin-like growth factor signalling pathway (IIS) has been extensively studied in species including nematode worms (e.g."C. elegans"), flies ("Drosophila melanogaster") and mice ("Mus musculus"). Its mechanisms of action are highly
Violet gland Violet gland The violet gland or supracaudal gland is a gland located on the upper surface of the tail of certain mammals, including European badgers and canids such as foxes, wolves, and the domestic dog, as well as the domestic cat. Like many other mammalian secretion glands, the violet gland consists of modified sweat glands and sebaceous glands. It is used for intra-species signalling, scent marking, and contributes to the strong odor of foxes in particular. Although it secretes a mixture of volatile terpenes similar to those produced by violets (hence the name), the chemicals are produced in much greater