Bayer 1853—a modification of salicylic acid or salicin, a folk remedy found in the bark of the willow plant. By 1899 Bayer's trademark Aspirin was registered worldwide for Bayer's brand of acetylsalicylic acid, but it lost its trademark status in the United States, France and the United Kingdom after the confiscation of Bayer's US assets and trademarks during World War I by the United States, and because of the subsequent widespread usage of the word. The term "aspirin" continued to be used in the US, UK and France for all brands of the drug, but it is still a registered trademark
Tetrolic acid (water, ethanol) and may be recrystallized from non polar solvents (such as heptane, toluene). The compound is a white crystalline solid which can exist in two polymorphous crystalline forms. The proton nuclear magnetic resonance (H-NMR) spectrum in deuterated dimethyl sulfoxide shows a characteristic singlet peak at 1.99 ppm corresponding to the -CH protons. Tetrolic acid Tetrolic acid (2-butynoic acid) is a short-chain unsaturated carboxylic acid, described by the formula CH-C≡C-COH. Salts and esters of tetrolic acid are known as tetrolates. The first reported synthesis of tetrolic acid is believed to be by German chemist Johann Georg Anton Geuther in 1871