Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
Hippocrates the year 460 BC on the Greek island of Kos; other biographical information, however, is likely to be untrue. Soranus of Ephesus, a 2nd-century Greek physician, was Hippocrates' first biographer and is the source of most personal information about him. Later biographies are in the "Suda" of the 10th century AD, and in the works of John Tzetzes, Aristotle's "Politics", which date from the 4th century BC. Soranus wrote that Hippocrates' father was Heraclides, a physician, and his mother was Praxitela, daughter of Tizane. The two sons of Hippocrates, Thessalus and Draco, and his son-in-law, Polybus, were his students. According