Natural product to modern discovery of their active ingredients and eventually to the development of new drugs. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. A few representative examples are listed below. Some of the oldest natural product based drugs are analgesics. The bark of the willow tree has been known from antiquity to have pain relieving properties. This is due to presence of the natural product salicin which in turn may be hydrolyzed into salicylic acid. A synthetic derivative acetylsalicylic acid better known as aspirin is a widely used pain reliever.
Willow pattern set up on his own account in c.1793 in Stoke-on-Trent producing earthenwares: he is thought to have engraved versions of willow designs for Spode and for various other factories. It was probably for Spode that the English Willow pattern was created and first produced perhaps around 1790, because it incorporates particular, distinctive features of earlier Chinese willow scenes which were already known and imitated at the Spode factory. The Willow pattern is commonly presented in a circular or ovate frame. The waterside landscape represents a garden in the lower right side, in which a large two-storey pavilion stands. Approached by