Willow bark of the willow tree have been mentioned in ancient texts from Assyria, Sumer and Egypt as a remedy for aches and fever, and in Ancient Greece the physician Hippocrates wrote about its medicinal properties in the fifth century BC. Native Americans across the Americas relied on it as a staple of their medical treatments. It provides temporary pain relief. Salicin is metabolized into salicylic acid in the human body, and is a precursor of aspirin. In 1763, its medicinal properties were observed by the Reverend Edward Stone in England. He notified the Royal Society, which published his findings. The
Quinic acid Quinic acid Quinic acid is a cyclitol, a cyclic polyol, and a cyclohexanecarboxylic acid. It is a colorless solid that can be extracted from plant sources. Quinic acid is implicated in the perceived acidity of coffee. The compound is obtained from cinchona bark, coffee beans, the bark of "Eucalyptus globulus". It is a constituent of the tara tannins. Urtica dioica is another common source. It is made synthetically by hydrolysis of chlorogenic acid. Quinic acid is also implicated in the perceived acidity of coffee. This substance was isolated for the first time in 1806 by French pharmacist Nicolas Vauquelin and