Willow bark of the willow tree have been mentioned in ancient texts from Assyria, Sumer and Egypt as a remedy for aches and fever, and in Ancient Greece the physician Hippocrates wrote about its medicinal properties in the fifth century BC. Native Americans across the Americas relied on it as a staple of their medical treatments. It provides temporary pain relief. Salicin is metabolized into salicylic acid in the human body, and is a precursor of aspirin. In 1763, its medicinal properties were observed by the Reverend Edward Stone in England. He notified the Royal Society, which published his findings. The
Asa Gray Gray had to borrow money from his father. Soon he was able to repay his father and help his family by supplementing his income giving lectures outside of Harvard, including at the Lowell Institute. Gray was considered a weak lecturer, but because of his expert knowledge, he was highly regarded by his peers. His skills were better suited to teaching advanced rather than introductory classes. He also gained renown for his textbooks and high quality illustrations. Gray moved into what became known as the Asa Gray House in the Botanic Garden in the summer of 1844. It had been built