Aspirin to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. By 1899, Bayer had dubbed this drug Aspirin and was selling it around the world. The word
Lune of Hippocrates circle. He proved that the lune bounded by the arcs labeled "E" and "F" in the figure has the same area as triangle "ABO". This afforded some hope of solving the circle-squaring problem, since the lune is bounded only by arcs of circles. Heath concludes that, in proving his result, Hippocrates was also the first to prove that the area of a circle is proportional to the square of its diameter. Hippocrates' book on geometry in which this result appears, "Elements", has been lost, but may have formed the model for Euclid's "Elements". Hippocrates' proof was preserved through the "History