Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
Endiandric acid C treatment with diethyl cinnamylphosphonate and LDA at low temperature in THF (generating en route the anionic olefination reagent) formed the desired diene in good yield in a "geometrically controlled manner", thus providing the desired endiandric acid C product. Endiandric acid C Endiandric acid C, isolated from the tree "Endiandra introrsa", is a well characterized chemical compound. Endiadric acid C is reported to have better antibiotic activity than ampicillin. This genus of trees is in the family Lauraceae. These trees are found in the north-eastern Australian rainforests and other tropical and subtropical regions. However, they are also found in southern Canada