Salix nigra bark of the tree contains salicylic acid, a chemical compound similar to aspirin (acetylsalicylic acid). It may also be used as an environmental restorative. Swamp trees in general are, by necessity, good at surviving and thriving in areas where highly mobile environmental toxins are present. Black Willow is very resistant to herbivory and flooding and is also a fantastic erosion control tool. Thus, it is useful for any sort of marshland stabilization or restorative as long as the roots don’t penetrate any clay liner that may be in place. In a relatively extensive phytoremediation study, "Salix nigra" demonstrated some success
Nonsteroidal anti-inflammatory drug inflammation and also used willow bark to mitigate them. On 25 April 1763, Edward Stone wrote to the Royal Society describing his observations on the use of willow bark-based medicines in febrile patients. The active ingredient of willow bark, a glycoside called salicin, was first isolated by Johann Andreas Buchner in 1827. By 1829, French chemist Henri Leroux had improved the extraction process to obtain about 30g of purified salicin from 1.5 kg of bark. By hydrolysis, salicin releases glucose and salicylic alcohol which can be converted into salicylic acid, both in vivo and through chemical methods. The acid is