Growth hormone secretagogue receptor secretagogue receptor is activated, a variety of different intracellular signaling cascades can result, depending on the cell type in which the receptor is expressed. These intracellular signaling cascades include mitogen-activated protein kinase (MAPK)), protein kinase A (PKA), protein kinase B (PKB), also known as AKT), and AMP Activated Protein Kinase (AMPK) cascades. It is well-characterized that activating the growth hormone secretagogue receptor with ghrelin induces an orexigenic state, or general feeling of hunger. However, ghrelin may also play a role in behavioral reinforcement. Studies in animal models, found that food intake increased when ghrelin was specifically administered to just the
Doctor Hormone lured Doctor Hormone and Jane into a mysterious gorge where they descended into The Chaos and fell into a state of suspended animation. The character has not appeared since. Doctor Hormone was a scientific genius who developed powerful "hormones" which were capable of creating great changes in the human body, including restoring youth and transforming people into animals or bizarre human-animal hybrids. The Thinker endowed Doctor Hormone with powers that included superhuman strength, a stentorian voice, and super-breath. Presumably, this was temporary. Doctor Hormone Doctor Hormone is a fictional character created by Bob Bugg, who briefly appeared in comic books