Crop diversity fruit trees and banana plants) are cloned. A single pest or disease could threaten a whole crop due to this uniformity ("genetic erosion"). A well-known historic case was the Irish Potato Famine of 1845-1847, where a vital crop with low diversity was destroyed by a single fungus. Another example is when a disease caused by a fungus affected the monocultured 1970 US corn crop, causing a loss of over one billion dollars in production. A danger to agriculture is wheat rust, a pathogenic fungus causing reddish patches, coloured by its spores. A virulent form of the wheat disease, stem rust,
Sandhoff disease Sandhoff disease have similar symptoms but to a lesser extent. Adult and juvenile forms of Sandhoff disease are more rare than the infantile form. In these cases victims suffer cognitive impairment (retardation) and a loss of muscle coordination that impairs and eventually destroys their ability to walk; the characteristic red spots in the retina also develop. The adult form of the disease, however, is sometimes milder, and may only lead to muscle weakness that impairs walking or the ability to get out of bed. Two parents carrying a mutated gene and passing it on to their offspring cause the disease.