Panama disease when the seedling is aneuploid, results are not as good. Second-generation breeding using those new tetraploids as both parents has tended not to yield good results, because the first generation contains the Gros Michel triploid gene set intact (plus possibly useful features in the added fourth chromosome set), but in the second generation, the Gros Michel gene set has been broken up by meiosis. The Honduras Foundation for Agricultural Research cultivates several varieties of the Gros Michel. They have succeeded in producing a few seeds by hand-pollinating the flowers with pollen from diploid seeded bananas. Panama disease Panama disease is
Little cherry disease the fruit crop less hidden by the canopy, and leaf symptoms, varying from a slight marginal up-curl of the leaves to marked reddening of leaf surfaces. The general vigor of infected trees may be impaired, though this is not always apparent. Diagnosis of the disease can be assisted by RT-PCR assays. Other "Prunus" species may act as symptomless or tolerant carriers of the disease; especially cultivars of Japanese flowering cherry ("Prunus serrulata") have been implicated as such. There is no known cure for little cherry disease and tolerance breeding programs have not yielded any cultivars able to withstand the effects