Alka-Seltzer Alka-Seltzer Alka-Seltzer is an effervescent antacid and pain reliever first marketed by the Dr. Miles Medicine Company of Elkhart, Indiana, United States. Alka-Seltzer contains three active ingredients: aspirin (acetylsalicylic acid) (ASA), sodium bicarbonate, and anhydrous citric acid. The aspirin is a pain reliever and anti-inflammatory, the sodium bicarbonate is an antacid, and the citric acid reacts with the sodium bicarbonate and water to form effervescence. It was developed by head chemist Maurice Treneer. Alka-Seltzer is marketed for relief of minor aches, pains, inflammation, fever, headache, heartburn, stomachache, indigestion, acid reflux and hangovers, while neutralizing excess stomach acid. It was launched
Hippocrates of Chios would be known too. Only much later was it proven (by Ferdinand von Lindemann, in 1882) that this approach had no chance of success, because the factor pi (π) is transcendental. The number π is the ratio of the circumference to the diameter of a circle, and also the ratio of the area to the square of the radius. In the century after Hippocrates at least four other mathematicians wrote their own "Elements", steadily improving terminology and logical structure. In this way Hippocrates' pioneering work laid the foundation for Euclid's "Elements" (c. 325 BC) that was to remain the standard