Growth hormone secretagogue receptor secretagogue receptor is activated, a variety of different intracellular signaling cascades can result, depending on the cell type in which the receptor is expressed. These intracellular signaling cascades include mitogen-activated protein kinase (MAPK)), protein kinase A (PKA), protein kinase B (PKB), also known as AKT), and AMP Activated Protein Kinase (AMPK) cascades. It is well-characterized that activating the growth hormone secretagogue receptor with ghrelin induces an orexigenic state, or general feeling of hunger. However, ghrelin may also play a role in behavioral reinforcement. Studies in animal models, found that food intake increased when ghrelin was specifically administered to just the
Maximum the Hormone suffering a herniated disc. Maximum the Hormone performs nu metal and hardcore punk but incorporates many elements of pop, funk, ska, hip hop and extreme metal into their music as well which helps to distinguish them from many typical nu metal and hardcore punk bands. The band is also labeled as alternative metal, funk metal, groove metal and more recently metalcore by some critics. AllMusic's Alexey Eremenko writes that Maximum the Hormone is distinguished by "a general lack of the teenage angst and self-importance characteristic of true nu-metalers". Their funky sound, heard in many songs such as "Maximum 21st Century",