Mark Selby in the first round of the UK Championship, scoring 6 breaks over 40 in those five frames. On 17 January 2010, Selby won his second Masters title after reaching the final for the third time in as many years in a repeat of the previous year's final, where he lost to Ronnie O'Sullivan. O'Sullivan took a commanding lead at 9–6 leaving him just one frame from victory, but Selby played some of his best snooker of the season to overcome the three-frame deficit, taking the championship 10–9 and the £150,000 winner's cheque. At the 2011 China Open, Selby beat Tian
Mark Selby Pengfei, Robert Milkins, Ali Carter, and home favourite Ding Junhui, but was defeated 8–10 by Judd Trump in the final. At the 2011 World Championship, Selby set the record for the most century breaks compiled in a world championship match when he made six in his second round tie with Stephen Hendry. It was also a record for a best-of-25 match and took Selby's century tally for the season to 54, setting a new record for the most centuries compiled in a season. Selby's 2011/2012 season began by winning the non-ranking Wuxi Classic with a 9–7 victory over Ali Carter.