Salicylic acid the OH group is "ortho" to the carboxyl group. It is also known as 2-hydroxybenzoic acid. It is poorly soluble in water (2 g/L at 20 °C). Aspirin (acetylsalicylic acid or ASA) can be prepared by the esterification of the phenolic hydroxyl group of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride. Salicylic acid can also be prepared using the Kolbe-Schmitt reaction. Salicylic acid is used as a food preservative, a bactericidal and an antiseptic. Sodium salicylate is a useful phosphor in the vacuum ultraviolet spectral range, with nearly flat quantum efficiency for wavelengths between 10
Bernardino Ramazzini medicine and played a substantial role in its development. He proposed that physicians should extend the list of questions that Hippocrates recommended they ask their patients by adding, "What is your occupation?". Ramazzini saw prevention as being better than cure. In his Oratio given in 1711, he suggested that "it is much better to prevent than to cure, and so much easier to foresee future harm and avoid it rather than have to get rid of it after having fallen prey". In regards to malaria, Ramazzini was one of the first to support the use of the quinine-rich bark cinchona.