Willow bark of the willow tree have been mentioned in ancient texts from Assyria, Sumer and Egypt as a remedy for aches and fever, and in Ancient Greece the physician Hippocrates wrote about its medicinal properties in the fifth century BC. Native Americans across the Americas relied on it as a staple of their medical treatments. It provides temporary pain relief. Salicin is metabolized into salicylic acid in the human body, and is a precursor of aspirin. In 1763, its medicinal properties were observed by the Reverend Edward Stone in England. He notified the Royal Society, which published his findings. The
Endiandric acid C treatment with diethyl cinnamylphosphonate and LDA at low temperature in THF (generating en route the anionic olefination reagent) formed the desired diene in good yield in a "geometrically controlled manner", thus providing the desired endiandric acid C product. Endiandric acid C Endiandric acid C, isolated from the tree "Endiandra introrsa", is a well characterized chemical compound. Endiadric acid C is reported to have better antibiotic activity than ampicillin. This genus of trees is in the family Lauraceae. These trees are found in the north-eastern Australian rainforests and other tropical and subtropical regions. However, they are also found in southern Canada