Growth hormone secretagogue receptor of selective ligands for the GHS-R receptor are now available and are being developed for several clinical applications. GHS-R agonists have appetite-stimulating and growth hormone-releasing effects, and are likely to be useful for the treatment of muscle wasting and frailty associated with old-age and degenerative diseases. On the other hand, GHS-R antagonists have anorectic effects and are likely to be useful for the treatment of obesity. Growth hormone secretagogue receptor Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R
Trophic hormone Trophic hormone Trophic hormone is a hormone that has a growth effect, hyperplasia or hypertrophy, on the tissue it is stimulating. The term "trophic" is from Ancient Greek τροφικός ("trophikós") meaning "pertaining to food or nourishment", here used to mean "growth"; this is the same origin as "atrophy." This should not be confused with "tropic," as in the similar-sounding tropic hormone – the words and concepts are both unrelated. A key example of this is thyroid-stimulating hormone stimulating the thyroid; excess thyroid-stimulating hormone can create a goitre. Trophic hormones from the anterior pituitary include: Gastrin is a trophic hormone that