Mark Selby with a shock 3–5 defeat to Andrew Pagett in the qualifying rounds of the 2013 Wuxi Classic. The tournament was the first to use a new format that required top-16 players to compete in qualifiers. In minor-ranking tournaments, Selby was runner-up in the Yixing Open, where he lost 1–4 to Joe Perry, and the Rotterdam Open, where he lost 3–4 to Mark Williams. He won the Antwerp Open, defeating Ronnie O'Sullivan 4–3 in the final. In December, in the seventh frame of his UK Championship semi-final against Ricky Walden, Selby compiled snooker's 100th officially recognised maximum break in professional competition.
Mark Selby beat his good friend Shaun Murphy 10–6 to win the tournament. Selby also participated at the Players Tour Championship. He successfully defended his Paul Hunter Classic title with a 4–1 win over Joe Swail in the final. He then lost in the final of the Antwerp Open 1–4 against Mark Allen, and won the Munich Open by defeating Graeme Dott 3–4 in the final. He then finished number one on the Order of Merit, and qualified for the Finals, where he lost 3–4 against Jack Lisowski. Selby then went on to win his third Masters title, beating Stuart Bingham 6–5