Multiple electrode aggregometry and ADP-receptors. Adding ASA (acetylsalicylic acid) reagent to a blood sample reduces the aggregation responses in ASPItest and COLtest. ASA irreversibly inhibits COX1 in platelets, thereby inhibiting the production of TXA2. The ASA Reagent is used as a quality control in the platelet function testing with Multiplate, allowing the assessment of abnormal platelet responses in ASPItest and COLtest. This reagent is used as a quality control in Multiplate platelet function testing. The GPIIb/IIIa antagonist blocks the binding of fibrinogen to the GPIIb/IIIa receptors, preventing the formation of platelet-fibrinogen bonds and resulting in significantly reduced platelet aggregation in response to all
Hippocrates of Chios would be known too. Only much later was it proven (by Ferdinand von Lindemann, in 1882) that this approach had no chance of success, because the factor pi (π) is transcendental. The number π is the ratio of the circumference to the diameter of a circle, and also the ratio of the area to the square of the radius. In the century after Hippocrates at least four other mathematicians wrote their own "Elements", steadily improving terminology and logical structure. In this way Hippocrates' pioneering work laid the foundation for Euclid's "Elements" (c. 325 BC) that was to remain the standard