Multiple electrode aggregometry and ADP-receptors. Adding ASA (acetylsalicylic acid) reagent to a blood sample reduces the aggregation responses in ASPItest and COLtest. ASA irreversibly inhibits COX1 in platelets, thereby inhibiting the production of TXA2. The ASA Reagent is used as a quality control in the platelet function testing with Multiplate, allowing the assessment of abnormal platelet responses in ASPItest and COLtest. This reagent is used as a quality control in Multiplate platelet function testing. The GPIIb/IIIa antagonist blocks the binding of fibrinogen to the GPIIb/IIIa receptors, preventing the formation of platelet-fibrinogen bonds and resulting in significantly reduced platelet aggregation in response to all
Hippocrates of Chios Hippocrates of Chios Hippocrates of Chios (; c. 470 – c. 410 BC) was an ancient Greek mathematician, geometer, and astronomer. He was born on the isle of Chios, where he was originally a merchant. After some misadventures (he was robbed by either pirates or fraudulent customs officials) he went to Athens, possibly for litigation. There he became a leading mathematician. On Chios, Hippocrates may have been a pupil of the mathematician and astronomer Oenopides of Chios. In his mathematical work there probably was some Pythagorean influence too, perhaps via contacts between Chios and the neighbouring island of Samos, a