Crop diversity are all susceptible to a single fungus, "Fusarium oxysporum" (Panama disease); large areas of the crop were destroyed by the fungus in the 1950s. 'Gros Michel' has been replaced by the current main banana on the market, the 'Cavendish', which in turn is (2015) at risk of total loss to a strain of the same fungus, 'Tropical Race 4'. Such threats can be countered by strategies such as planting multi-line cultivars and cultivar mixes, in the hope that some of the cultivars will be resistant to any individual outbreak of disease. The implications of crop diversity are at both local
Plant disease resistance for disease resistance originated with Sir Rowland Biffen, who identified a single recessive gene for resistance to wheat yellow rust. Nearly every crop was then bred to include disease resistance (R) genes, many by introgression from compatible wild relatives. The term GM ("genetically modified") is often used as a synonym of transgenic to refer to plants modified using recombinant DNA technologies. Plants with transgenic/GM disease resistance against insect pests have been extremely successful as commercial products, especially in maize and cotton, and are planted annually on over 20 million hectares in over 20 countries worldwide (see also genetically modified crops).