History of aspirin History of aspirin The history of aspirin (IUPAC name acetylsalicylic acid ) begins with its synthesis and manufacture in 1899. Before that, salicylic acid had been used medicinally since antiquity. Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to their use of salicylic tea to reduce fevers around 400 BC, and were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. Willow bark extract became recognized for its specific effects on fever, pain and inflammation in the
Endiandric acid C treatment with diethyl cinnamylphosphonate and LDA at low temperature in THF (generating en route the anionic olefination reagent) formed the desired diene in good yield in a "geometrically controlled manner", thus providing the desired endiandric acid C product. Endiandric acid C Endiandric acid C, isolated from the tree "Endiandra introrsa", is a well characterized chemical compound. Endiadric acid C is reported to have better antibiotic activity than ampicillin. This genus of trees is in the family Lauraceae. These trees are found in the north-eastern Australian rainforests and other tropical and subtropical regions. However, they are also found in southern Canada