Localized disease diseases. Some diseases are capable of changing from local to disseminated diseases. Pneumonia, for example, is generally confined to one or both lungs but can become disseminated through sepsis, in which the microbe responsible for the pneumonia "seeds" the bloodstream or lymphatic system and is transported to distant sites in the body. When that occurs, the process is no longer described as a localized disease, but rather as a disseminated disease. Localized disease A localized disease is an infectious or neoplastic process that originates in and is confined to one organ system or general area in the body, such as
Lewy body dementia with Parkinson's disease, and according to his widow he experienced depression, anxiety, and increasing paranoia. Upon autopsy his widow said he was found to have diffuse DLB. Ian G. McKeith, a dementia researcher and professor of old age psychiatry, commented that DLB was still too little known, and that Williams' symptoms were explained by DLB. The LBDA clarified the distinction between the term used in the autopsy report, "diffuse Lewy body dementia"—which is more commonly called "diffuse Lewy body disease" and refers to the underlying disease process—and the umbrella term, "Lewy body dementia," which encompasses both PDD and DLB. According