Whipple's disease Whipple's disease Whipple's disease is a rare, systemic infectious disease caused by the bacterium "Tropheryma whipplei". First described by George Hoyt Whipple in 1907 and commonly considered a gastrointestinal disorder, Whipple's disease primarily causes malabsorption but may affect any part of the body including the heart, brain, joints, skin, lungs and the eyes. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms, but the presentation can be highly variable and approximately 15% of patients do not have these classic signs and symptoms. Whipple's disease is significantly more common in men, with 87% of the patients being male. When
Lewy body dementia with Parkinson's disease, and according to his widow he experienced depression, anxiety, and increasing paranoia. Upon autopsy his widow said he was found to have diffuse DLB. Ian G. McKeith, a dementia researcher and professor of old age psychiatry, commented that DLB was still too little known, and that Williams' symptoms were explained by DLB. The LBDA clarified the distinction between the term used in the autopsy report, "diffuse Lewy body dementia"—which is more commonly called "diffuse Lewy body disease" and refers to the underlying disease process—and the umbrella term, "Lewy body dementia," which encompasses both PDD and DLB. According