Panama disease include mostly sanitation and quarantine practices to prevent the spread of Panama disease out of infected fields. However, the most effective tool against Panama disease is the development of banana trees resistant to "Fusarium oxysporum f. sp. Cubense". Unfortunately, the clonal reproduction of banana has led to a consequential lack of other varieties. Efforts are being made to produce resistant varieties, but with bananas being triploids which do not produce seeds, this is not an easy task. Creating clones from tissue cultures, rather than suckers, has proven somewhat successful in breeding resistant varieties, however, these tend to have decreased success
Crop diversity possess valuable traits for crop breeding, such as pest and disease resistance. Some 6% of wild relatives of cereal crops such as wheat, maize, rice, and sorghum are under threat, as are 18% of legumes (Fabaceae), the wild relatives of beans, peas and lentils, and 13% of species within the botanical family (Solanaceae) that includes potato, tomato, eggplant (aubergine), and peppers ("Capsicum"). In 2016, 29% of wild relative plant species were completely missing from the world’s genebanks, with a further 24% represented by fewer than 10 samples. Over 70% of all crop wild relative species worldwide were in urgent need