Ghrelin growth hormone secretagogue receptor, with the "GHS-R1b" splice being inactive) is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase in hunger, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion, protection of neuronal and cardiovascular cells, and regulation of immune function. They are present in high density in the hypothalamus and pituitary, on the vagus nerve (on both afferent cell bodies and afferent nerve endings) and throughout the gastrointestinal tract. Ghrelin promotes intestinal cell proliferation and inhibits apoptosis during inflammatory states and oxidative stress. It also suppresses
Trophic hormone causes hyperplasia of enterochromaffin cells which may transform into carcinoid tumors. Trophic hormone Trophic hormone is a hormone that has a growth effect, hyperplasia or hypertrophy, on the tissue it is stimulating. The term "trophic" is from Ancient Greek τροφικός ("trophikós") meaning "pertaining to food or nourishment", here used to mean "growth"; this is the same origin as "atrophy." This should not be confused with "tropic," as in the similar-sounding tropic hormone – the words and concepts are both unrelated. A key example of this is thyroid-stimulating hormone stimulating the thyroid; excess thyroid-stimulating hormone can create a goitre. Trophic hormones