Aspirin to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. By 1899, Bayer had dubbed this drug Aspirin and was selling it around the world. The word
Willow flute tempered scale. Modern willow flutes are typically made of plastic (PVC tubing is often used), but the original willow flutes were made from sections of bark cut from green willow branches. Willow flutes could only be made this way during the spring, and became unplayable when the bark dried out. Noted modern willow flute artists include the group Hedningarna and Anders Norudde of Sweden. Other Scandinavian groups that use the Seljefløyte in traditional arrangements include Eivind Groven, Steinar Ofsdal, Groupa and Bask. There is also a Karelian variant of the willow flute that is made in Finnish Karelia and the