Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
Fluoroacetic acid Fluoroacetic acid Fluoroacetic acid is a chemical compound with formula CHFCOOH. The sodium salt, sodium fluoroacetate, is used as a pesticide. It inhibits the aconitase step of the citric acid cycle. Fluoroacetate occurs naturally in at least 40 plants in Australia, Brazil, and Africa. It is one of only five known organic fluorine-containing natural products. It was first identified in "Dichapetalum cymosum", commonly known as gifblaar (Afrikaans) or poison leaf, by Marais in 1944. As early as 1904, colonists in Sierra Leone used extracts of "Chailletia toxicaria", which also contains fluoroacetic acid or its salts, to poison rats. Several native