Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
Willow flute Russian Republic of Karelia. It is made the same way as the willow flute, but instead of willow bark, it is made out of birch bark. The Karelian Folk Music Ensemble, based out of Petrozavodsk in Russian Karelia, uses this instrument in their music. Willow flute The willow flute, also known as sallow flute (, or "sälgpipa", or "pajupilli"), is a Nordic folk flute, or whistle, consisting of a simple tube with a transverse fipple mouthpiece and no finger holes. The mouthpiece is typically constructed by inserting a grooved plug into one end of the tube, and cutting an edged