Arthur Eichengrün the invention of aspirin in 1897. Impure acetylsalicylic acid (ASA, the active compound of aspirin) had been synthesized already in 1853 by French chemist Charles Frédéric Gerhardt; the 1897 process developed at Bayer was the first to produce pure ASA that could be used for medical purposes. Due to the rise of the Nazis in Germany, Eichengrün was unable to object when Hoffman first made the claim that "he" (Hoffman) invented aspirin, in the footnote of a 1934 German Encyclopedia. Hoffman's claim was once widely accepted, but many historians now consider it to be discredited. Eichengrün first claimed to have
Bernardino Ramazzini medicine and played a substantial role in its development. He proposed that physicians should extend the list of questions that Hippocrates recommended they ask their patients by adding, "What is your occupation?". Ramazzini saw prevention as being better than cure. In his Oratio given in 1711, he suggested that "it is much better to prevent than to cure, and so much easier to foresee future harm and avoid it rather than have to get rid of it after having fallen prey". In regards to malaria, Ramazzini was one of the first to support the use of the quinine-rich bark cinchona.