Aspirin to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. By 1899, Bayer had dubbed this drug Aspirin and was selling it around the world. The word
Lune of Hippocrates give the only constructible squarable lunes; in particular, there are no constructible squarable convex lunes. Lune of Hippocrates In geometry, the lune of Hippocrates, named after Hippocrates of Chios, is a lune bounded by arcs of two circles, the smaller of which has as its diameter a chord spanning a right angle on the larger circle. Equivalently, it is a non-convex plane region bounded by one 180-degree circular arc and one 90-degree circular arc. It is the first curved figure to have its exact area calculated mathematically. Hippocrates wanted to solve the classic problem of squaring the circle, i.e. constructing