Ghrelin growth hormone secretagogue receptor, with the "GHS-R1b" splice being inactive) is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase in hunger, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion, protection of neuronal and cardiovascular cells, and regulation of immune function. They are present in high density in the hypothalamus and pituitary, on the vagus nerve (on both afferent cell bodies and afferent nerve endings) and throughout the gastrointestinal tract. Ghrelin promotes intestinal cell proliferation and inhibits apoptosis during inflammatory states and oxidative stress. It also suppresses
Adrenocorticotropic hormone (medication) Adrenocorticotropic hormone (medication) Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test. The form that is purified from pig pituitary glands is known as corticotropin (INN, BAN) is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior pituitary gland. The form that is made synthetically is tetracosactide (INN), also known as tetracosactrin (BAN) and cosyntropin (USAN), and the acetate ester, tetracosactide acetate (JAN), also known as tetracosactrin acetate (BAN). It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function