Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
A. C. and Mamie Forehand A. C. and Mamie Forehand A. C. (also, "Asey" or "Asa") Forehand and (Blind) Mamie Forehand were husband and wife American gospel musicians. They recorded four songs for Victor Records in 1927. A. C. is credited with the two songs recorded on February 25, and Mamie with the two recorded on February 28according to which one of them sang, but both played on all four: A. C. guitar and harmonica, Mamie an instrument variously identified as triangle or finger cymbals. A. C. was born in Columbus, Georgia on August 9, 1890 (according to his second wife, Frances) or 1893 (according