Salix nigra bark of the tree contains salicylic acid, a chemical compound similar to aspirin (acetylsalicylic acid). It may also be used as an environmental restorative. Swamp trees in general are, by necessity, good at surviving and thriving in areas where highly mobile environmental toxins are present. Black Willow is very resistant to herbivory and flooding and is also a fantastic erosion control tool. Thus, it is useful for any sort of marshland stabilization or restorative as long as the roots don’t penetrate any clay liner that may be in place. In a relatively extensive phytoremediation study, "Salix nigra" demonstrated some success
Bernardino Ramazzini medicine and played a substantial role in its development. He proposed that physicians should extend the list of questions that Hippocrates recommended they ask their patients by adding, "What is your occupation?". Ramazzini saw prevention as being better than cure. In his Oratio given in 1711, he suggested that "it is much better to prevent than to cure, and so much easier to foresee future harm and avoid it rather than have to get rid of it after having fallen prey". In regards to malaria, Ramazzini was one of the first to support the use of the quinine-rich bark cinchona.