Natural product to modern discovery of their active ingredients and eventually to the development of new drugs. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. A few representative examples are listed below. Some of the oldest natural product based drugs are analgesics. The bark of the willow tree has been known from antiquity to have pain relieving properties. This is due to presence of the natural product salicin which in turn may be hydrolyzed into salicylic acid. A synthetic derivative acetylsalicylic acid better known as aspirin is a widely used pain reliever.
Willow flute Russian Republic of Karelia. It is made the same way as the willow flute, but instead of willow bark, it is made out of birch bark. The Karelian Folk Music Ensemble, based out of Petrozavodsk in Russian Karelia, uses this instrument in their music. Willow flute The willow flute, also known as sallow flute (, or "sälgpipa", or "pajupilli"), is a Nordic folk flute, or whistle, consisting of a simple tube with a transverse fipple mouthpiece and no finger holes. The mouthpiece is typically constructed by inserting a grooved plug into one end of the tube, and cutting an edged