Growth hormone secretagogue receptor of selective ligands for the GHS-R receptor are now available and are being developed for several clinical applications. GHS-R agonists have appetite-stimulating and growth hormone-releasing effects, and are likely to be useful for the treatment of muscle wasting and frailty associated with old-age and degenerative diseases. On the other hand, GHS-R antagonists have anorectic effects and are likely to be useful for the treatment of obesity. Growth hormone secretagogue receptor Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R
Counterregulatory hormone rise in blood concentrations of these counterregulatory hormones is dependent upon both exercise intensity and duration, and is proportional to the rate of glucose uptake by the contracting skeletal muscle. Similarly, the natriuretic peptides counterregulate against renin, angiotensin, and aldosterone which elevate blood pressure. In the reproductive system, inhibins and follistatin counterregulate activins, to control follicle-stimulating hormone and so the release of gonads. Inhibins and activins also regulate bone mass. Counterregulatory hormone A counterregulatory hormone is a hormone that opposes the action of another. The action of insulin is counterregulated by glucagon, epinephrine (adrenaline), norepinephrine (noradrenaline), cortisol, and growth hormone.