Willow bark of the willow tree have been mentioned in ancient texts from Assyria, Sumer and Egypt as a remedy for aches and fever, and in Ancient Greece the physician Hippocrates wrote about its medicinal properties in the fifth century BC. Native Americans across the Americas relied on it as a staple of their medical treatments. It provides temporary pain relief. Salicin is metabolized into salicylic acid in the human body, and is a precursor of aspirin. In 1763, its medicinal properties were observed by the Reverend Edward Stone in England. He notified the Royal Society, which published his findings. The
Hippocrates of Chios geometry textbook for many centuries. Hippocrates is believed to have originated the use of letters to refer to the geometric points and figures in a proposition, e.g., "triangle ABC" for a triangle with vertices at points A, B, and C. Two other contributions by Hippocrates in the field of mathematics are noteworthy. He found a way to tackle the problem of 'duplication of the cube', that is, the problem of how to construct a cube root. Like the quadrature of the circle this was another of the so-called three great mathematical problems of antiquity. Hippocrates also invented the technique of