Growth hormone secretagogue receptor Growth hormone secretagogue receptor Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R is thought to be in regulating energy homeostasis and body weight. In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra. Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even
Trophic hormone causes hyperplasia of enterochromaffin cells which may transform into carcinoid tumors. Trophic hormone Trophic hormone is a hormone that has a growth effect, hyperplasia or hypertrophy, on the tissue it is stimulating. The term "trophic" is from Ancient Greek τροφικός ("trophikós") meaning "pertaining to food or nourishment", here used to mean "growth"; this is the same origin as "atrophy." This should not be confused with "tropic," as in the similar-sounding tropic hormone – the words and concepts are both unrelated. A key example of this is thyroid-stimulating hormone stimulating the thyroid; excess thyroid-stimulating hormone can create a goitre. Trophic hormones