Growth hormone secretagogue receptor Growth hormone secretagogue receptor Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R is thought to be in regulating energy homeostasis and body weight. In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra. Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even
Counterregulatory hormone rise in blood concentrations of these counterregulatory hormones is dependent upon both exercise intensity and duration, and is proportional to the rate of glucose uptake by the contracting skeletal muscle. Similarly, the natriuretic peptides counterregulate against renin, angiotensin, and aldosterone which elevate blood pressure. In the reproductive system, inhibins and follistatin counterregulate activins, to control follicle-stimulating hormone and so the release of gonads. Inhibins and activins also regulate bone mass. Counterregulatory hormone A counterregulatory hormone is a hormone that opposes the action of another. The action of insulin is counterregulated by glucagon, epinephrine (adrenaline), norepinephrine (noradrenaline), cortisol, and growth hormone.