Multiple electrode aggregometry and ADP-receptors. Adding ASA (acetylsalicylic acid) reagent to a blood sample reduces the aggregation responses in ASPItest and COLtest. ASA irreversibly inhibits COX1 in platelets, thereby inhibiting the production of TXA2. The ASA Reagent is used as a quality control in the platelet function testing with Multiplate, allowing the assessment of abnormal platelet responses in ASPItest and COLtest. This reagent is used as a quality control in Multiplate platelet function testing. The GPIIb/IIIa antagonist blocks the binding of fibrinogen to the GPIIb/IIIa receptors, preventing the formation of platelet-fibrinogen bonds and resulting in significantly reduced platelet aggregation in response to all
Lune of Hippocrates Lune of Hippocrates In geometry, the lune of Hippocrates, named after Hippocrates of Chios, is a lune bounded by arcs of two circles, the smaller of which has as its diameter a chord spanning a right angle on the larger circle. Equivalently, it is a non-convex plane region bounded by one 180-degree circular arc and one 90-degree circular arc. It is the first curved figure to have its exact area calculated mathematically. Hippocrates wanted to solve the classic problem of squaring the circle, i.e. constructing a square by means of straightedge and compass, having the same area as a given