History of aspirin mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it.
Asa C. Matthews as collector of the United States Internal Revenue. In 1889, President Benjamin Harrison appointed Matthews comptroller of the United States Treasury. In 1893, Matthews wrote a vignette for the World's Fair predicting what life in the U.S. would be like 100 years in the future. His predictions were grandiose, predicting the U.S. having 60 states and controlling all of North America. Matthews died suddenly at his home in Pittsfield, Illinois. Asa C. Matthews Asa Carrington Matthews (March 22, 1833 – June 14, 1908) was an American lawyer, judge, and politician. Born in Pike County, Illinois, Matthews went to the public