Natural product to modern discovery of their active ingredients and eventually to the development of new drugs. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. A few representative examples are listed below. Some of the oldest natural product based drugs are analgesics. The bark of the willow tree has been known from antiquity to have pain relieving properties. This is due to presence of the natural product salicin which in turn may be hydrolyzed into salicylic acid. A synthetic derivative acetylsalicylic acid better known as aspirin is a widely used pain reliever.
Willow Bunch, Saskatchewan Willow Bunch community, settled in what is part of the present-day Jean Louis Légaré Regional Park. Légaré, who married into the Métis community, opened a trading post/store there, and often traded various necessities to the local Métis for bison goods. In the spring of 1881, it was estimated he had around $3,000 worth of bison products in his store. A boy named Édouard Beaupré, better known as the Willow Bunch Giant, was the first child born and baptized in the area in 1881. The forerunner settlement of Willow Bunch was established in 1883, around two miles east of Légaré's store