John Gough (natural philosopher) wife and seven of their children. He was buried in the parish churchyard of Kendal. Gough had wide-ranging scientific interests. He published papers in natural history, mechanics, mathematics, chemistry, and experimental physics. One of his most interesting pieces of work was an investigation into the properties of natural rubber or Caoutchouc. He was the first to describe the heat released when a rubber band is quickly stretched, the heat being detected by the lips to which the band is pressed. When stretched rubber is heated, it contracts, a reversal of the normal behaviour of materials when heated. Gough published these
Substance P of the SP preferring receptor, i.e., by drugs known as neurokinin type 1 antagonists (also termed: SP antagonists, or tachykinin antagonists.) One such drug is aprepitant to prevent the nausea and vomiting that accompanies chemotherapy, typically for cancer. With the exception of chemotherapy-induced nausea and vomiting, the patho-physiological basis of many of the disease groups listed below, for which NK1RAs have been studied as a therapeutic intervention, are to varying extents hypothesized to be initiated or advanced by a chronic non-homeostatic inflammatory response. High levels of BDNF and substance P have been found associated with increased itching in eczema. To