Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
Asa Gray Gray had to borrow money from his father. Soon he was able to repay his father and help his family by supplementing his income giving lectures outside of Harvard, including at the Lowell Institute. Gray was considered a weak lecturer, but because of his expert knowledge, he was highly regarded by his peers. His skills were better suited to teaching advanced rather than introductory classes. He also gained renown for his textbooks and high quality illustrations. Gray moved into what became known as the Asa Gray House in the Botanic Garden in the summer of 1844. It had been built