Aspirin to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. By 1899, Bayer had dubbed this drug Aspirin and was selling it around the world. The word
Lymphatic endothelium vessels considered less important. Later it was discovered that VEGF-R3 and VEGF-C/VEGF-D were the key growth factors controlling lymphatic endothelial proliferation. Markers of lymphatic endolthelium were not discovered until relatively recently. These being LYVE-1 (Jackson et al.,1999) and podoplanin (Kerjaschki,1999). Endothelium Lymphatic endothelium The lymphatic endothelium is a specialised form of epithelium, distinct from but similar to vascular endothelium. A lymph capillary endothelial cell is distinct from other endothelial cells in that collagen fibers are directly attached to its plasma membrane. Although lymphatics were first described by Hippocrates in 400BC and rediscovered as "milky veins in the gut of a