Panama disease in stress-tolerance, yield, or other beneficial traits necessary for commercial varieties. Nevertheless, these efforts are leading to the best control measure for Panama disease of banana. Recently, an R gene (RGA2) was transformed into Cavendish bananas which confers disease resistance to Fusarium wilt tropical race 4. This is the first case of successful resistance in the field and is a promising step towards preventing the loss of the Cavendish cultivars that are a huge portion of banana export production and subsistence of many communities. One major impediment to breeding bananas is polyploidy; Gros Michel and Cavendish bananas are triploid and
Sandhoff disease Sandhoff disease have similar symptoms but to a lesser extent. Adult and juvenile forms of Sandhoff disease are more rare than the infantile form. In these cases victims suffer cognitive impairment (retardation) and a loss of muscle coordination that impairs and eventually destroys their ability to walk; the characteristic red spots in the retina also develop. The adult form of the disease, however, is sometimes milder, and may only lead to muscle weakness that impairs walking or the ability to get out of bed. Two parents carrying a mutated gene and passing it on to their offspring cause the disease.