History of aspirin mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it.
Willow flute Russian Republic of Karelia. It is made the same way as the willow flute, but instead of willow bark, it is made out of birch bark. The Karelian Folk Music Ensemble, based out of Petrozavodsk in Russian Karelia, uses this instrument in their music. Willow flute The willow flute, also known as sallow flute (, or "sälgpipa", or "pajupilli"), is a Nordic folk flute, or whistle, consisting of a simple tube with a transverse fipple mouthpiece and no finger holes. The mouthpiece is typically constructed by inserting a grooved plug into one end of the tube, and cutting an edged