Amazon rubber boom the expansion of Iquitos in Peru. The rubber boom occurred largely between 1879 and 1912. There was heightened rubber production and associated activities from 1942 to 1945 during the Second World War. Natural rubber is an elastomer, also known as tree gum, India rubber, and "caoutchouc," which comes from the rubber tree in tropical regions. Christopher Columbus was the one of the first Europeans to bring news of this odd substance back to Europe, but he was not the only one to report it. Around 1736, a French astronomer recalled how Amerindians used rubber to waterproof shoes and cloaks. He
Substance P nominally so, as it is ubiquitous. Its receptor – the neurokinin type 1 – is distributed over cytoplasmic membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes. Substance P is a key first responder to most noxious/extreme stimuli (stressors), i.e., those with a potential to compromise biological integrity. SP is thus regarded as an immediate defense, stress, repair, survival system. The molecule, which is rapidly inactivated (or at times further activated by peptidases) is rapidly released – repetitively and