Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
Birch bark manuscript In Indian sculpture, a Birch bark manuscript is easily identified by the droop. A palm leaf manuscript is stiff. On July 26, 1951, during excavations in Novgorod, a Soviet expedition led by Artemiy Artsikhovsky found the first Russian birch bark writing in a layer dated to c. 1400. Since then, more than 1,000 similar documents were discovered in Staraya Russa, Smolensk, Torzhok, Pskov, Tver, Moscow, Ryazan, and Vologda, although Novgorod remains by far the most prolific source of them. In Ukraine, birch bark documents were found in Zvenyhorod, Volynia. In Belarus, several documents were unearthed in Vitebsk and Mstislavl. The