John Gough (natural philosopher) wife and seven of their children. He was buried in the parish churchyard of Kendal. Gough had wide-ranging scientific interests. He published papers in natural history, mechanics, mathematics, chemistry, and experimental physics. One of his most interesting pieces of work was an investigation into the properties of natural rubber or Caoutchouc. He was the first to describe the heat released when a rubber band is quickly stretched, the heat being detected by the lips to which the band is pressed. When stretched rubber is heated, it contracts, a reversal of the normal behaviour of materials when heated. Gough published these
Natural product the isolation of "analytical quantities" of the substance of interest, where the focus is on identification and quantitation of the substance (e.g. in biological tissue or fluid), and where the quantity isolated depends on the analytical method applied (but is generally always sub-microgram in scale). The ease with which the active agent can be isolated and purified depends on the structure, stability, and quantity of the natural product. The methods of isolation applied toward achieving these two distinct scales of product are likewise distinct, but generally involve extraction, precipitation, adsorptions, chromatography, and sometimes crystallizations. In both cases, the isolated substance