Salicylic acid 4-aminosalicylic acid, sandulpiride, and landetimide (via Salethamide). Salicylic acid was one of the original starting materials for making acetylsalicylic acid (aspirin) in 1897. Bismuth subsalicylate, a salt of bismuth and salicylic acid, is the active ingredient in stomach relief aids such as Pepto-Bismol, is the main ingredient of Kaopectate and "displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic". Other derivatives include methyl salicylate used as a liniment to soothe joint and muscle pain and choline salicylate used topically to relieve the pain of mouth ulcers. Salicylic acid has the formula CH(OH)COOH, where
Bernardino Ramazzini medicine and played a substantial role in its development. He proposed that physicians should extend the list of questions that Hippocrates recommended they ask their patients by adding, "What is your occupation?". Ramazzini saw prevention as being better than cure. In his Oratio given in 1711, he suggested that "it is much better to prevent than to cure, and so much easier to foresee future harm and avoid it rather than have to get rid of it after having fallen prey". In regards to malaria, Ramazzini was one of the first to support the use of the quinine-rich bark cinchona.