Salicylic acid the product with sulfuric acid gives salicylic acid: It can also be prepared by the hydrolysis of aspirin (acetylsalicylic acid) or methyl salicylate (oil of wintergreen) with a strong acid or base. Hippocrates, Galen, Pliny the Elder and others knew that willow bark could ease pain and reduce fevers. It was used in Europe and China to treat these conditions. This remedy is mentioned in texts from ancient Egypt, Sumer and Assyria. The Cherokee and other Native Americans used an infusion of the bark for fever and other medicinal purposes. In 2014, archaeologists identified traces of salicylic acid on 7th
Hippocrates widely considered to be the "Father of Medicine". His contributions revolutionized the practice of medicine; but after his death the advancement stalled. So revered was Hippocrates that his teachings were largely taken as too great to be improved upon and no significant advancements of his methods were made for a long time. The centuries after Hippocrates' death were marked as much by retrograde movement as by further advancement. For instance, "after the Hippocratic period, the practice of taking clinical case-histories died out," according to Fielding Garrison. After Hippocrates, the next significant physician was Galen, a Greek who lived from AD