Crop diversity are all susceptible to a single fungus, "Fusarium oxysporum" (Panama disease); large areas of the crop were destroyed by the fungus in the 1950s. 'Gros Michel' has been replaced by the current main banana on the market, the 'Cavendish', which in turn is (2015) at risk of total loss to a strain of the same fungus, 'Tropical Race 4'. Such threats can be countered by strategies such as planting multi-line cultivars and cultivar mixes, in the hope that some of the cultivars will be resistant to any individual outbreak of disease. The implications of crop diversity are at both local
Plant disease resistance include the Ring and U-box single subunit, HECT, and CRLs. Plant signaling pathways including immune responses are controlled by several feedback pathways, which often include negative feedback; and they can be regulated by De-ubiquitination enzymes, degradation of transcription factors and the degradation of negative regulators of transcription. Plant breeders emphasize selection and development of disease-resistant plant lines. Plant diseases can also be partially controlled by use of pesticides and by cultivation practices such as crop rotation, tillage, planting density, disease-free seeds and cleaning of equipment, but plant varieties with inherent (genetically determined) disease resistance are generally preferred. Breeding for disease