Salicylic acid 4-aminosalicylic acid, sandulpiride, and landetimide (via Salethamide). Salicylic acid was one of the original starting materials for making acetylsalicylic acid (aspirin) in 1897. Bismuth subsalicylate, a salt of bismuth and salicylic acid, is the active ingredient in stomach relief aids such as Pepto-Bismol, is the main ingredient of Kaopectate and "displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic". Other derivatives include methyl salicylate used as a liniment to soothe joint and muscle pain and choline salicylate used topically to relieve the pain of mouth ulcers. Salicylic acid has the formula CH(OH)COOH, where
Hippocrates of Chios geometry textbook for many centuries. Hippocrates is believed to have originated the use of letters to refer to the geometric points and figures in a proposition, e.g., "triangle ABC" for a triangle with vertices at points A, B, and C. Two other contributions by Hippocrates in the field of mathematics are noteworthy. He found a way to tackle the problem of 'duplication of the cube', that is, the problem of how to construct a cube root. Like the quadrature of the circle this was another of the so-called three great mathematical problems of antiquity. Hippocrates also invented the technique of