Serum amyloid P component Serum amyloid P component The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". APCS is its human gene. AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death.
Greatest Hits (Blood, Sweat & Tears album) Greatest Hits (Blood, Sweat & Tears album) Greatest Hits is a compilation album by the band Blood, Sweat & Tears, initially released in 1972. Although Blood, Sweat & Tears continued to record and tour for several more years, the band's lineup changed dramatically after "Blood, Sweat & Tears 4". This compilation album includes all of the group's best-known material up to that time. This was the group's last album to earn a Gold Record award. Columbia initially chose to incorporate the edited single versions of many of the songs, a decision which was poorly received by some fans. Some later