Dental amalgam controversy demonstrated that mercury released from amalgam restorations does not give rise to toxic effects on the nervous system of children. More recently, a Cochrane Systematic review in 2014 found, "insufficient evidence to support or refute any adverse effects associated with amalgam or composite restorations." Those opposed to dental amalgam suggest that mercury from dental amalgam may lead to nephrotoxicity, neurobehavioural changes, autoimmunity, oxidative stress, autism, skin and mucosa alterations, non-specific symptoms and complaints, Alzheimer's disease, and multiple sclerosis. Both those opposed and those not opposed to dental amalgam recognize that amalgam has been found to be a rare contributor to
Dental amalgam controversy years. All available world-wide research indicates that amalgam is not harmful to health... No Government or reputable scientific, medical or dental body anywhere in the world accepts, on any published evidence, that dental amalgam is a hazard to health." The Irish Dental Association provides additional detail in a published patient information letter. France has publicly recognized the safety and effectiveness of amalgam restorations. A position paper on the Association Dentaire Française website states that amalgam restorations have proven to have no biological or toxic effect. They also mention that no serious pathological fact has ever been observed and no general