Two-second rule two seconds as inadequate, and recommend a three-second rule. German law requires a minimum 0.9 second distance but when tested under relaxed conditions researchers found that their test subjects spent 41% of the test time at following distances under 0.9 second. The United States National Safety Council suggests that a three-second rule—with increases of one second per factor of driving difficulty—is more appropriate. Factors that make driving more difficult include poor lighting conditions (dawn and dusk are the most common); inclement weather (ice, rain, snow, fog, etc.), adverse traffic mix (heavy vehicles, slow vehicles, impaired drivers, pedestrians, bicyclists, etc.), and
Lipinski's rule of five easier time in delivering optimized drug development candidates that are also drug-like. Hence the rule of five has been extended to the rule of three (RO3) for defining lead-like compounds. A rule of three compliant compound is defined as one that has: Lipinski's rule of five Lipinski's rule of five also known as the Pfizer's rule of five or simply the rule of five (RO5) is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would make it a likely orally active