Serum (blood) form of immunotherapy. Blood serum and plasma are some of the largest sources of biomarkers, whether for diagnostics or therapeutics. Its vast dynamic range, further complicated by the presence of lipids, salts, and post-translational modifications, as well multiple mechanisms of degradation, presents challenges in analytical reproducibility, sensitivity, resolution, and potential efficacy. For analysis of biomarkers in blood serum samples, it is possible to do a pre-separation by free-flow electrophoresis that usually consists of a depletion of serum albumin protein. This method enables greater penetration of the proteome via separation of a wide variety of charged or chargeable analytes, ranging from
Blood, Sweat and Stanley Poole Blood, Sweat and Stanley Poole Blood, Sweat and Stanley Poole is a 1961 play by William Goldman and James Goldman. Both Goldman brothers had served in the army and the play is about a supply sergeant at an army post in the south. William Goldman later recalled "we had both been in the army at the same time and it seemed like a decent enough idea and magically we got it on." William and James Goldman had been permitted to serve together in the army in 1955. They were stationed with the 101th Airborne division. The Goldman brothers had received