Dental amalgam controversy an increasing number of studies with larger sample sizes are being conducted. Those who are not opposed to amalgam claim that, aside from rare and localized tissue irritation, recent evidence-based research has continued to demonstrate no ill effects from the minute amounts of mercury exposure from amalgam fillings. A 2004 systematic review conducted by the Life Sciences Research Office, whose clients include the FDA and NIH, concluded that, "the current data are insufficient to support an association between mercury release from dental amalgam and the various complaints that have been attributed to this restoration material." A systematic review in 2009
Amalgam (dentistry) or longer to reach a reasonably high value. At the time when the patient is dismissed from the surgery, typically some 15–20 minutes after placing the filling, the amalgam is relatively weak. Therefore, dentists need to instruct patients not to apply undue stress to their freshly placed amalgam fillings. In addition, amalgam restorations are brittle and susceptible to corrosion. The alloys are broadly classified as low-copper (5% or less copper) and high-copper alloys (13% to 30% copper). The solid particles of the alloy are either spherical or irregularly shaped microspheres of various sizes or a combination of the two. The