Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
The Big Toe Radio Show conventional current affairs programmes. "The Big Toe Radio Show" ended on 16 March 2007, but the format was adapted to become the hour-long Big Toe Books on BBC Radio 7 at 4pm on weekdays and 8am on weekends. The show consisted of a presenter (Christopher Pizzey, formerly Kirsten O'Brien) introducing the story or summarising previous episodes. The last episode was broadcast on BBC Radio 4 Extra on Saturday 2 April 2011. The main presenters were: Other presenters: The Big Toe Radio Show The Big Toe Radio Show was a daily show (seven days a week) for children on the DAB