Cunningham's Rule constructions because they tend to average out how many times a variable pivots. It has recently been shown by David Avis and Oliver Friedmann that there is a family of linear programs on which the simplex algorithm equipped with Cunningham's rule requires exponential time. Cunningham's Rule In mathematical optimization, Cunningham's rule (also known as least recently considered rule or round-robin rule) is an algorithmic refinement of the simplex method for linear optimization. The rule was proposed 1979 by W.H. Cunningham to defeat the deformed hypercube constructions by Klee and Minty et. al. (see, e.g. Klee–Minty cube). Cunningham's rule assigns a
Lipinski's rule of five easier time in delivering optimized drug development candidates that are also drug-like. Hence the rule of five has been extended to the rule of three (RO3) for defining lead-like compounds. A rule of three compliant compound is defined as one that has: Lipinski's rule of five Lipinski's rule of five also known as the Pfizer's rule of five or simply the rule of five (RO5) is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would make it a likely orally active