Monsanto the disposition of product lines unrelated to agriculture. In 1985, Monsanto acquired G. D. Searle & Company, a life sciences company that focused on pharmaceuticals, agriculture and animal health. In 1993, its Searle division filed a patent application for Celebrex, which in 1998 became the first selective COX‑2 inhibitor to be approved by the U.S. Food and Drug Administration (FDA). Celebrex became a blockbuster drug and was often mentioned as a key reason for Pfizer's acquisition of Monsanto's pharmaceutical business in 2002. In 1994, Monsanto introduced a recombinant version of bovine somatotropin, brand-named Posilac. Monsanto later sold this business to
Castle of Monsanto an unknown commander. As a result of this change, in 1174, a new foral was issued to the inhabitants of Monsanto, by D. Afonso Henriques, which was confirmed in 1190 by D. Sancho I. A contemporary castle was constructed during the 13th century. It was reconstructed in the 14th century, during the reigns of King D. Dinis and D. Fernando. But, following its alignment with the Kingdom of Castile during the 1383–1385 Portuguese interregnum, the site began to fall into disorder. According to the chronicler Fernão Lopes, Monsanto was a village that had been loyal to Queen Beatrice. But, later