Dental amalgam controversy an increasing number of studies with larger sample sizes are being conducted. Those who are not opposed to amalgam claim that, aside from rare and localized tissue irritation, recent evidence-based research has continued to demonstrate no ill effects from the minute amounts of mercury exposure from amalgam fillings. A 2004 systematic review conducted by the Life Sciences Research Office, whose clients include the FDA and NIH, concluded that, "the current data are insufficient to support an association between mercury release from dental amalgam and the various complaints that have been attributed to this restoration material." A systematic review in 2009
Dental amalgam controversy ADA asserts the best scientific evidence supports the safety of dental amalgam. Clinical studies have not established an occasional connection between dental amalgam and adverse health effects in the general population. In 2002, Dr. Maths Berlin of The Dental Material Commission published an overview and assessment of the scientific literature published between November 1997 – 2002 for the Swedish Government on amalgam and its possible environmental and health risks. A final report was submitted to the Swedish Government in 2003 and included his report as an annex to the full report. In the final report from 2003, Berlin states that