Irish Famine (1740–41) affect economies, energy sources, and politics. Although no barometric or temperature readings for Ireland survive from the Great Frost, a scattered few records survive from Englishmen who made personal readings. The mercury thermometer was invented 25 years earlier by the German pioneer Daniel Gabriel Fahrenheit. Indoor values during January 1740 were as low as . The one outdoor reading that has survived was stated as "thirty-two degrees of frost." This did not include the effects of the wind chill factor, which would have been severe. This kind of weather was "quite outside the Irish experience," notes David Dickson, author of
IbpB thermometer IbpB thermometer The IbpB thermometer is an RNA thermometer element found in the "ibpAB" operon. The operon contains two heat-shock genes, encoding inclusion body binding proteins A and B (IbpA/B), and is the most drastically upregulated operon under heat-shock in "Escherichia coli". "IbpA" is regulated by a ROSE element found in its 5' UTR, while "IbpB" has its own heat-sensitive cis-regulatory element. The activity of this thermoregulator was confirmed "in vitro" but was not found "in vivo", suggesting more complicated operon regulation exists in bacterial cells. The IbpB protein, whose expression is regulated by the IbpB thermometer, is 48% identical