Dental amalgam controversy demonstrated that mercury released from amalgam restorations does not give rise to toxic effects on the nervous system of children. More recently, a Cochrane Systematic review in 2014 found, "insufficient evidence to support or refute any adverse effects associated with amalgam or composite restorations." Those opposed to dental amalgam suggest that mercury from dental amalgam may lead to nephrotoxicity, neurobehavioural changes, autoimmunity, oxidative stress, autism, skin and mucosa alterations, non-specific symptoms and complaints, Alzheimer's disease, and multiple sclerosis. Both those opposed and those not opposed to dental amalgam recognize that amalgam has been found to be a rare contributor to
Amalgam (dentistry) or longer to reach a reasonably high value. At the time when the patient is dismissed from the surgery, typically some 15–20 minutes after placing the filling, the amalgam is relatively weak. Therefore, dentists need to instruct patients not to apply undue stress to their freshly placed amalgam fillings. In addition, amalgam restorations are brittle and susceptible to corrosion. The alloys are broadly classified as low-copper (5% or less copper) and high-copper alloys (13% to 30% copper). The solid particles of the alloy are either spherical or irregularly shaped microspheres of various sizes or a combination of the two. The