Diabetes and Inflammation Laboratory members include:- Diabetes and Inflammation Laboratory The JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/WT DIL), centred in the Cambridge Institute for Medical Research, is a multi-disciplinary research programme within the department of Medical Genetics at the University of Cambridge. The current director is John Todd FMedSci FRS and Professor of Medical Genetics at the University of Cambridge. The goals of the JDRF/WT DIL are to identify and characterise the effects of the susceptibility genes for type 1 diabetes in order to better understand the earliest events in human physiology that lead to autoimmune destruction of the insulin-producing beta-cells of pancreas.
Epigenetics of diabetes Type 2 was seen in an experiment when a high glucose treatment of cultured monocytes increased recruitment of the HATs CREB-binding protein (CPB) and PCAF, leading to increased histone lysine acetylation at the cyclooxygenase-2 (COX-2) and TNF-inflammatory gene promoters. This led to a corresponding increase in gene expression, which was similar to the increased histone lysine acetylation at these gene promoters in type 1 diabetes and type 2 diabetes patients compared to healthy control volunteers. There are several factors that put people at higher risk of contracting Type 2 diabetes. Among these are obesity, lack of exercise, and aging. But, not everyone