Collagen hereditary link. Collagen is one of the long, fibrous structural proteins whose functions are quite different from those of globular proteins, such as enzymes. Tough bundles of collagen called "collagen fibers" are a major component of the extracellular matrix that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. Collagen has great tensile strength, and is the main component of fascia, cartilage, ligaments, tendons, bone and skin. Along with elastin and soft keratin, it is responsible for skin strength and elasticity, and its degradation leads to wrinkles that accompany aging. It
National Institute of Arthritis and Musculoskeletal and Skin Diseases regulate differentiation and regeneration of skeletal muscle. The ultimate goal of these studies is to provide a practical conceptual PDCTC framework. Laboratory of Oral Connective Tissue Biology—studies the molecular biology of dental-oral-craniofacial development, with a focus on teeth, gums and jaws. The aim of these studies is to understand cells and signals influencing tooth, bone, and periodontal ligament development. Laboratory of Skin Biology—studies the regulation of epidermal differentiation, skin barrier formation, and inflammatory responses associated with barrier dysfunction. A major focus is basic investigation of ectodermal appendage development and the study of human ectodermal dysplasias. Laboratory of Stem Cell Biology—studies