Dense irregular connective tissue stretching forces from different directions. Dense irregular connective tissue also makes up submucosa of the digestive tract, fibrous capsules of joints and lymph nodes, and some types of fascia. Other examples include periosteum and perichondrium of bones, and the tunica albuginea of testis. In the submucosa layer, the fiber bundles course in varying planes allowing the organ to resist excessive stretching and distension. Dense irregular connective tissue Dense irregular connective tissue has fibers that are not arranged in parallel bundles as in dense regular connective tissue. Dense irregular connective tissue consists of mostly collagen fibers. It has less ground substance
Connective tissue disease also vasculitis. Connective tissue diseases can have strong or weak inheritance risks, and can also be caused by environmental factors. These are also referred to as systemic autoimmune diseases. The autoimmune CTDs may have both genetic and environmental causes. Genetic factors may create a predisposition towards developing these autoimmune diseases. They are characterized as a group by the presence of spontaneous overactivity of the immune system that results in the production of extra antibodies into the circulation. The classic collagen vascular diseases have a "classic" presentation with typical findings that doctors can recognize during an examination. Each also has "classic"