Dental amalgam controversy demonstrated that mercury released from amalgam restorations does not give rise to toxic effects on the nervous system of children. More recently, a Cochrane Systematic review in 2014 found, "insufficient evidence to support or refute any adverse effects associated with amalgam or composite restorations." Those opposed to dental amalgam suggest that mercury from dental amalgam may lead to nephrotoxicity, neurobehavioural changes, autoimmunity, oxidative stress, autism, skin and mucosa alterations, non-specific symptoms and complaints, Alzheimer's disease, and multiple sclerosis. Both those opposed and those not opposed to dental amalgam recognize that amalgam has been found to be a rare contributor to
Dental amalgam controversy removing toxic substances from the body, when such treatment is performed solely at the recommendation or suggestion of the dentist, is improper and unethical". Under the comments of the American Dental Association before the FDA's Dental Products Panel of the Medical Devices Advisory Committee, the ADA supports the 2009 FDA ruling on dental amalgam. ADA states that "dental amalgam has an established record of safety and effectiveness, which the scientific community has extensively reviewed and affirmed." The ADA also supports the 2017 EPA wastewater regulation and is providing information and assistance to its members in implementation of amalgam separators. The