Serum amyloid P component Serum amyloid P component The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". APCS is its human gene. AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death.
Blood, Sweat & Tears (Blood, Sweat & Tears album) Blood, Sweat & Tears (Blood, Sweat & Tears album) Blood, Sweat & Tears is the second album by the band Blood, Sweat & Tears, released in 1968. It was commercially successful, rising to the top of the U.S. charts for a collective seven weeks and yielding three successive Top 5 singles. It received a Grammy Award for Album of the Year in 1970 and has been certified quadruple platinum by the RIAA with sales of more than four million units in the U.S. In Canada, it enjoyed four runs and altogether eight weeks at No. 1 on the "RPM" national