Cobalt chelatase Cobalt chelatase Cobalt chelatase () is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are ATP, hydrogenobyrinic acid a,c-diamide, Co, and HO, whereas its 4 products are ADP, phosphate, cob(II)yrinic acid a,c-diamide, and H. The aerobic cobalt chelatase (aerobic cobalamin biosynthesis pathway) consists of three subunits, CobT, CobN () and CobS (). Cobalamin (vitamin B12) can be complexed with metal via the ATP-dependent reactions (aerobic pathway) (e.g., in "Pseudomonas denitrificans") or via ATP-independent reactions (anaerobic pathway) (e.g., in "Salmonella typhimurium"). The corresponding cobalt chelatases are not homologous. However, aerobic cobalt chelatase subunits CobN and CobS
Chemical element plants, the calcium in mollusc shells, or the iron in the hemoglobin in vertebrate animals' red blood cells. The concept of an "element" as an undivisible substance has developed through three major historical phases: Classical definitions (such as those of the ancient Greeks), chemical definitions, and atomic definitions. Ancient philosophy posited a set of classical elements to explain observed patterns in nature. These "elements" originally referred to "earth", "water", "air" and "fire" rather than the chemical elements of modern science. The term 'elements' ("stoicheia") was first used by the Greek philosopher Plato in about 360 BCE in his dialogue Timaeus,