Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
Septic arthritis maximal in this position. In peri-articular arthritis, pain only occurs when the joint is moved, and the lesion usually lies in one specific area around the joint. The most common joint affected is the knee. Hip, shoulder, wrist, and elbow joints are less commonly affected. Spine, sternoclavicular, and sacroiliac joints can also be involved. The most common cause of arthritis in these joints is intravenous drug use. Usually only one joint is affected. More than one joint can be involved if bacteria are spread through the bloodstream. For those with artificial joint implants, there is a chance of 0.86 to