Serum amyloid P component conserved in all vertebrates and also found in distant invertebrates such as the horseshoe crab (Limulus polyphemus). Serum amyloid P component The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". APCS is its human gene. AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal
Eccrine sweat gland duct, the "acrosyringium"; a dermal duct, consisting of a straight and coiled portion; and a secretory tubule, coiled deep in the dermis or hypodermis. The eccrine gland opens out through the sweat pore. The coiled portion is formed by two concentric layer of columnar or cuboidal epithelial cells. The epithelial cells are interposed by the myoepithelial cells. Myoepithelial cells support the secretory epithelial cells. The duct of eccrine gland is formed by two layers of cuboidal epithelial cells. Eccrine glands are active in thermoregulation by providing cooling from water evaporation of sweat secreted by the glands on the body surface