Serum amyloid P component conserved in all vertebrates and also found in distant invertebrates such as the horseshoe crab (Limulus polyphemus). Serum amyloid P component The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". APCS is its human gene. AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal
Blood, Sweat & Tears 4 Blood, Sweat & Tears 4 Blood, Sweat & Tears 4 is the fourth album by the band Blood, Sweat & Tears, released in 1971. It peaked at number 10 on the Billboard Pop albums chart. The band invited former member Al Kooper to contribute the song "John the Baptist (Holy John)." Trombonist Dave Bargeron replaced Jerry Hyman. David Clayton-Thomas left as lead vocalist to pursue a solo career after the release of "BS&T 4", as did founding members Dick Halligan and Fred Lipsius. Clayton-Thomas would return to the lineup for "New City". Writing for Allmusic, critic William Ruhlman wrote "the