Origin and use of the term metalloid antimony and tellurium, was recorded merely on a 'sometimes' basis. Use of the term metalloid subsequently underwent a period of great flux up to 1940. Consensus as to its application to intermediate or borderline elements did not occur until the ensuing years, between 1940 and 1960. In 1947, Pauling included a reference to metalloids in his classic and influential textbook, "General chemistry: An introduction to descriptive chemistry and modern chemical theory." He described them as 'elements with intermediate properties ... occupy[ing] a diagonal region [on the periodic table], which includes boron, silicon, germanium, arsenic, antimony, tellurium, and polonium.' In 1959
Period 5 element diverse functions of the remainder of the enzymes, molybdenum is a required element for life in higher organisms (eukaryotes), though not in all bacteria. Technetium, ruthenium, rhodium, palladium, silver, tin, and antimony have no biological role. Although cadmium has no known biological role in higher organisms, a cadmium-dependent carbonic anhydrase has been found in marine diatoms. Indium has no biological role and can be toxic as well as Antimony. Tellurium has no biological role, although fungi can incorporate it in place of sulfur and selenium into amino acids such as tellurocysteine and telluromethionine. In humans, tellurium is partly metabolized into