Dental amalgam controversy an increasing number of studies with larger sample sizes are being conducted. Those who are not opposed to amalgam claim that, aside from rare and localized tissue irritation, recent evidence-based research has continued to demonstrate no ill effects from the minute amounts of mercury exposure from amalgam fillings. A 2004 systematic review conducted by the Life Sciences Research Office, whose clients include the FDA and NIH, concluded that, "the current data are insufficient to support an association between mercury release from dental amalgam and the various complaints that have been attributed to this restoration material." A systematic review in 2009
Dental amalgam controversy they contain Bis-phenol A (BPA) a chemical known to cause reproductive toxicity at high doses. In Canada, amalgam use is considered safe and effective. A 2005 position statement from the Canadian Dental Association (CDA) states that "current scientific evidence on the use of dental amalgam supports that amalgam is an effective and safe filling material that provides a long-lasting solution for a broad range of clinical situations. The CDA has established its position based on the current consensus of scientific and clinical experts and on recent extensive reviews of strong evidence by major North American and international organizations, which have