Calamine (mineral) enough was known of metallic zinc to make brass solder directly by combining copper and spelter (zinc ingots). In 1738 a patent was granted to William Champion, a Bristol brass founder, for the large-scale reduction of calamine to produce spelter. In 1684 a paper presented to the Royal Society touched on the medicinal and veterinary properties of the compound when in finely powdered form. Calamine (mineral) Calamine is a historic name for an ore of zinc. The name "calamine" was derived from "lapis calaminaris", a Latin corruption of Greek "cadmia (καδμία)", the old name for zinc ores in general. The
Period 4 element can also be found in semiconductors. Germanium (Ge) is an element in period 4, between gallium and arsenic. Germanium, like silicon above it, is an important semiconductor and is commonly used in diodes and transistors, often in combination with arsenic. Germanium is fairly rare on Earth, leading to its comparatively late discovery. Germanium, in compounds, can sometimes irritate the eyes, skin, or lungs. Arsenic (As) is an element in period 4, between germanium and selenium. Arsenic, as mentioned above, is often used in semiconductors in alloys with germanium. Arsenic, in pure form and some alloys, is incredibly poisonous to all