Serum (blood) form of immunotherapy. Blood serum and plasma are some of the largest sources of biomarkers, whether for diagnostics or therapeutics. Its vast dynamic range, further complicated by the presence of lipids, salts, and post-translational modifications, as well multiple mechanisms of degradation, presents challenges in analytical reproducibility, sensitivity, resolution, and potential efficacy. For analysis of biomarkers in blood serum samples, it is possible to do a pre-separation by free-flow electrophoresis that usually consists of a depletion of serum albumin protein. This method enables greater penetration of the proteome via separation of a wide variety of charged or chargeable analytes, ranging from
New Blood (Blood, Sweat & Tears album) New Blood (Blood, Sweat & Tears album) New Blood is the fifth album by the band Blood, Sweat & Tears, released in 1972. With David Clayton-Thomas leaving as lead vocalist to pursue a solo career after the release of "BS&T 4", a nearly wholesale personnel change occurred for "New Blood". Difficulties had arisen inside the group between its pop-rock and jazz factions, with Clayton-Thomas choosing to leave in early January 1972, along with founding member Fred Lipsius. Clayton-Thomas was briefly replaced by Bobby Doyle, and a photo of the band appeared in Down Beat showing a new lineup also including