Dense irregular connective tissue stretching forces from different directions. Dense irregular connective tissue also makes up submucosa of the digestive tract, fibrous capsules of joints and lymph nodes, and some types of fascia. Other examples include periosteum and perichondrium of bones, and the tunica albuginea of testis. In the submucosa layer, the fiber bundles course in varying planes allowing the organ to resist excessive stretching and distension. Dense irregular connective tissue Dense irregular connective tissue has fibers that are not arranged in parallel bundles as in dense regular connective tissue. Dense irregular connective tissue consists of mostly collagen fibers. It has less ground substance
Collagenopathy, types II and XI Collagenopathy, types II and XI The type II and XI collagenopathies are a group of disorders that affect connective tissue, the tissue that supports the body's joints and organs. These disorders are caused by defects in type II or type XI collagen. Collagens are complex molecules that provide structure, strength, and elasticity to connective tissue. Type II and type XI collagen disorders are grouped together because both types of collagen are components of the cartilage found in joints and the spinal column, the inner ear, and the jelly-like substance that fills the eyeball (the vitreous). The type II and XI