Cobalt chelatase Cobalt chelatase Cobalt chelatase () is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are ATP, hydrogenobyrinic acid a,c-diamide, Co, and HO, whereas its 4 products are ADP, phosphate, cob(II)yrinic acid a,c-diamide, and H. The aerobic cobalt chelatase (aerobic cobalamin biosynthesis pathway) consists of three subunits, CobT, CobN () and CobS (). Cobalamin (vitamin B12) can be complexed with metal via the ATP-dependent reactions (aerobic pathway) (e.g., in "Pseudomonas denitrificans") or via ATP-independent reactions (anaerobic pathway) (e.g., in "Salmonella typhimurium"). The corresponding cobalt chelatases are not homologous. However, aerobic cobalt chelatase subunits CobN and CobS
Cobalt poisoning One such example was seen in an experiment involving the effects of increased cobalt concentration on tomato plants. As the dosage of cobalt in the soil surrounding the plants increased, so too did the rate of necrosis of the leaves of the tomato plant. Over time this led to an inability of the plant to produce fruit and eventually the plant died. Cobalt poisoning Cobalt poisoning is intoxication caused by excessive levels of cobalt in the body. Cobalt is an essential element for health in animals in minute amounts as a component of Vitamin B. A deficiency of cobalt, which