Diabetes mellitus type 2 and primarily a lack of insulin secretion. Other potentially important mechanisms associated with type 2 diabetes and insulin resistance include: increased breakdown of lipids within fat cells, resistance to and lack of incretin, high glucagon levels in the blood, increased retention of salt and water by the kidneys, and inappropriate regulation of metabolism by the central nervous system. However, not all people with insulin resistance develop diabetes, since an impairment of insulin secretion by pancreatic beta cells is also required. The World Health Organization definition of diabetes (both type 1 and type 2) is for a single raised glucose reading
Saturated fat and cardiovascular disease increasing consumption of monounsaturated fats and polyunsaturated fats could lower risk of cardiovascular disease by about 30%. A 2015 systematic review also found no association between saturated fat consumption and risk of heart disease, stroke, diabetes, or death. A 2015 systematic review of randomized control trials by the Cochrane Library found that reducing saturated fat intake resulted in a 17% reduction in cardiovascular events, and that replacing saturated fats with "cis" unsaturated fats in particular is beneficial. It concluded: "Lifestyle advice to all those at risk of cardiovascular disease and to lower risk population groups should continue to include permanent