Dental amalgam controversy an increasing number of studies with larger sample sizes are being conducted. Those who are not opposed to amalgam claim that, aside from rare and localized tissue irritation, recent evidence-based research has continued to demonstrate no ill effects from the minute amounts of mercury exposure from amalgam fillings. A 2004 systematic review conducted by the Life Sciences Research Office, whose clients include the FDA and NIH, concluded that, "the current data are insufficient to support an association between mercury release from dental amalgam and the various complaints that have been attributed to this restoration material." A systematic review in 2009
Dental amalgam controversy years. All available world-wide research indicates that amalgam is not harmful to health... No Government or reputable scientific, medical or dental body anywhere in the world accepts, on any published evidence, that dental amalgam is a hazard to health." The Irish Dental Association provides additional detail in a published patient information letter. France has publicly recognized the safety and effectiveness of amalgam restorations. A position paper on the Association Dentaire Française website states that amalgam restorations have proven to have no biological or toxic effect. They also mention that no serious pathological fact has ever been observed and no general