Dental amalgam controversy an increasing number of studies with larger sample sizes are being conducted. Those who are not opposed to amalgam claim that, aside from rare and localized tissue irritation, recent evidence-based research has continued to demonstrate no ill effects from the minute amounts of mercury exposure from amalgam fillings. A 2004 systematic review conducted by the Life Sciences Research Office, whose clients include the FDA and NIH, concluded that, "the current data are insufficient to support an association between mercury release from dental amalgam and the various complaints that have been attributed to this restoration material." A systematic review in 2009
Amalgam Digital in hip hop music and distribution. In an April 2008 issue, "The Source" proclaimed that Amalgam Digital has "its finger on the pulse of hip-hop's future." Based in East Boston, the Amalgam Digital label is distributed exclusively by Amalgam Entertainment LLC, a distribution company that offers management, marketing, and promotional services. As an independent label, Amalgam Digital been home to such artists as Max B, Saigon, Curren$y, Chuuwee, Joe Budden, Peedi Crakk, Tash, Kurious, Juggaknots, Tame One, and Lil B. Joe Budden's album released by the label, "Padded Room", reached #42 in the "Billboard" 200 chart and #21 in the