Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
Toe ring married status. Some men frequently wore a ring on the big toe for curative purposes or to augment their masculine vigor. These rings were seldom closed circles but open hoops so that they could easily be removed. Toe rings were introduced to the United States by "Marjorie Borell" who, after returning from India began manufacturing and selling them in New York in 1973. Her first retail outlet was Fiorucci, a trendy fashion retailer located on 59th Street in New York. The ""Original Toe Ring Boutique"" sold toe rings in silver, gold and with diamonds. She eventually sold them in Bloomingdale's