Epigenetics of diabetes Type 2 have shown that miRNAs have pivotal roles in many different gene regulatory pathways. A subset of miRNAs has been shown to be involved in metabolic regulation of glucose homeostasis and in epigenetics of diabetes type 2. Pancreatic islet-specific miR-375 inhibits insulin secretion in mouse pancreatic β-cells by inhibiting the expression of the protein myotrophin. An overexpression of miR-375 can completely suppress glucose-induced insulin secretion, while inhibition of native miR-375 will increase insulin secretion. In another study, increasing the level of miR-9, a different miRNA, resulted in a severe defect in glucose-stimulated insulin release. This happens because miR-9 down-regulated the transcription
The Environmental Determinants of Diabetes in the Young The Environmental Determinants of Diabetes in the Young The Environmental Determinants of Diabetes in the Young is a longitudinal study examining the environmental causes of Type 1 diabetes(T1D), formerly known as juvenile diabetes. The study follows children at high genetic risk for T1D from birth to 15 years of age. Although genetic markers for Type 1 Diabetes have been identified, genetic predisposition is not the only factor in development of the disease. An increasing body of evidence, including rising rates of T1D diagnosis and incomplete penetrance of the disease in genetically predisposed individuals, suggests that environment may play an equally