Diabetes mellitus type 2 and primarily a lack of insulin secretion. Other potentially important mechanisms associated with type 2 diabetes and insulin resistance include: increased breakdown of lipids within fat cells, resistance to and lack of incretin, high glucagon levels in the blood, increased retention of salt and water by the kidneys, and inappropriate regulation of metabolism by the central nervous system. However, not all people with insulin resistance develop diabetes, since an impairment of insulin secretion by pancreatic beta cells is also required. The World Health Organization definition of diabetes (both type 1 and type 2) is for a single raised glucose reading
Diabetes Health Profile Diabetes Health Profile The Diabetes Health Profile (DHP) is a diabetes-specific patient reported outcome measure (PROM) developed to evaluate the health-related quality of life (HRQoL) of people living with Type 1 and Type 2 diabetes aged 16 years and older. It has been used in community surveys, research studies, clinical trials, and educational interventions both in Europe and completed globally by more than 10,000 patients. The DHP is the diabetes-specific PROM selected by the UK Department of Health for their Long Terms Conditions PROM Pilot Study being carried out by Oxford University. Based on a conceptual model the DHP-1 was