Epigenetics of diabetes Type 2 Since Type 2 diabetes is characterized by chronic hyperglycaemia as a result of impaired pancreatic beta cell function and insulin resistance in peripheral tissues, it was thought that the gene might be downregulated in type 2 diabetes patients through DNA methylation. The defects in pancreatic beta cell function and insulin resistance in peripheral tissues were thought to be the result of impaired ATP production from reduced oxidative phosphorylation. It was found that the mRNA expression of PPARGC1A was markedly reduced in pancreatic islets from type 2 diabetic donors compared with that of non-diabetic donors. Using bisulfite testing, it was also
Type 1 Diabetes Association a 501(c)(3) tax-exempt organization. Its national spokesperson is Jon Strishak, also a type 1 diabetic, who appears in public service announcements for the organization. Type 1 Diabetes Association The Type 1 Diabetes Association (T1DA) is a US nonprofit charity providing type 1 diabetes information, advocacy, and resources. The Type 1 Diabetes Association was founded in 2007 by Jon Strishak, a Type 1 diabetic marathon runner. The mission of the Type 1 Diabetes Association is to improve the quality of life for those living with type 1 diabetes. To fulfill this mission, the Type 1 Diabetes Association seeks to raises awareness