Mannheim of 1848, the city was a centre for political and revolutionary activity. In 1865, Friedrich Engelhorn founded the "Badische Anilin- und Soda-Fabrik" (Baden Aniline and Soda Factory, BASF) in Mannheim, but the factory was constructed across the Rhine in Ludwigshafen because Mannheim residents feared air pollution from its operations. From this dye factory, BASF has developed into the largest chemical company in the world. After opening a workshop in Mannheim in 1871 and patenting engines from 1878, Karl Benz patented the first motor car in 1886. He was born in Mühlburg (now part of Karlsruhe). The Schütte-Lanz company, founded by
Aniline blue, which is pure aniline; aniline oil for red, a mixture of equimolecular quantities of aniline and ortho- and para-toluidines; and aniline oil for safranine, which contains aniline and ortho-toluidine and is obtained from the distillate (échappés) of the fuchsine fusion. Many analogues of aniline are known where the phenyl group is further substituted. These include toluidines, xylidines, chloroanilines, aminobenzoic acids, nitroanilines, and many others. They often are prepared by nitration of the substituted aromatic compounds followed by reduction. For example, this approach is used to convert toluene into toluidines and chlorobenzene into 4-chloroaniline. Alternatively, using Buchwald-Hartwig coupling or Ullmann