Lipid-binding serum glycoprotein airway smooth muscle contractility by binding to and inhibiting the Ca2+ influx channel Orai1. BPI; BPIL1; BPIL2; BPIL3; CETP; LBP; LPLUNC1; LPLUNC3; LPLUNC4; PLTP; PLUNC; SPLUNC2; Lipid-binding serum glycoprotein In molecular biology, the lipid-binding serum glycoproteins family, also known as the BPI/LBP/Plunc family or LBP/BPI/CETP family represents a family which includes mammalian lipid-binding serum glycoproteins. Members of this family include: These proteins consist of N- and C-terminal domains, which share a similar two-layer alpha/beta structure, but show little sequence identity to each other. Bactericidal permeability-increasing protein (BPI) is a potent antimicrobial protein of 456 amino acids that binds to and
Blood, toil, tears, and sweat Blood, toil, tears, and sweat The phrase "blood, toil, tears and sweat" became famous in a speech given by Winston Churchill to the House of Commons of the Parliament of the United Kingdom on 13 May 1940. This was Churchill's first speech on 13 May 1940 to the House of Commons after having been offered the King's commission the previous Friday, to become Prime Minister of the United Kingdom in the first year of World War II. Churchill had replaced Neville Chamberlain on 10 May, and in this speech he asked the House to declare its confidence in his Government.