Gout Less antigenic versions are in development. Gout Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint. Pain typically comes on rapidly, reaching maximal intensity in less than twelve hours. The joint at the base of the big toe is affected in about half of cases. It may also result in tophi, kidney stones, or urate nephropathy. Gout is due to persistently elevated levels of uric acid in the blood. This occurs due to a combination of diet and genetic factors. At high levels, uric acid crystallizes and the crystals deposit
Systemic inflammatory response syndrome Systemic inflammatory response syndrome Systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. It is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. SIRS is frequently complicated by failure of one or more organs or organ systems. The complications of SIRS include: The causes of SIRS are broadly classified as infectious or noninfectious. Causes of SIRS include: Other causes include: SIRS is a serious condition related to systemic inflammation, organ dysfunction, and organ failure. It is