Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
When the Heartache Is Over of the joy of liberation from a love gone bad—once the heartache has passed. It's a positive message that will bring in a new generation of pop listeners, while allowing adults to crack a smile and tap a toe to the worldwide return of one of contemporary music's greatest achievers and most-cherished performers." The music video, which was filmed by British director Paul Boyd, features Turner dancing on a giant "T" with other dancers around her on the ground. The video was choreographed by Tina Landon. The background is black with a big screen that has flashing colours on it.