Diabetes and Inflammation Laboratory Diabetes and Inflammation Laboratory The JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/WT DIL), centred in the Cambridge Institute for Medical Research, is a multi-disciplinary research programme within the department of Medical Genetics at the University of Cambridge. The current director is John Todd FMedSci FRS and Professor of Medical Genetics at the University of Cambridge. The goals of the JDRF/WT DIL are to identify and characterise the effects of the susceptibility genes for type 1 diabetes in order to better understand the earliest events in human physiology that lead to autoimmune destruction of the insulin-producing beta-cells of pancreas. Other notable
Epigenetics of diabetes Type 2 associated FTO gene, which has shown to increase susceptibility to both obesity and Type 2 Diabetes. When looked at further, it was shown to have increased methylation levels in a haplotype associated with Type 2 Diabetes. To find exactly which portion of the gene led to the higher levels of risk, one group of researchers performed a sliding window analysis. Using the information, they narrowed the search down to the 46 kb linkage disequilibrium block, and within that region found a 7.7 kb region in which methylation levels were abnormally high. Pyrosequencing found that this difference was due to single