Coccinellidae of deadly crimes. Ladybirds have served as the US state insects of Delaware, Massachusetts, New Hampshire, New York, Ohio, and Tennessee, though only New York has selected a species native to the United States ("Coccinella novemnotata"); the other states have all adopted an invasive European species ("Coccinella septempunctata"). They have also been adopted as the mascot of Candanchú, a ski resort near Canfranc in the Spanish Pyrenees. Coccinellidae Coccinellidae () is a widespread family of small beetles ranging in size from 0.8 to 18 mm (0.03 to 0.71 inches). The family is commonly known as ladybugs in North America, and
Histone variants common histone H3 variants are H3.3 and centromeric H3 variant (cenH3, called also CENPA in humans). Well studied species specific variants include H3.1, H3.2, TS H3.4 (mammals), H3.5 (hominids), H3.Y (primates). Except for cenH3 histone, H3 variants are highly sequence conserved differing only by a few amino acids. Histone H3.3 has been found to play an important role in maintaining genome integrity during the mammalian development. Histone H4 is one of the slowest evolving proteins with no functional variants in the majority of species. The reason for a lack of sequence variants remains unclear. Trypanosoma are known to have a