Aniline Germany. Today, the name of BASF, originally "Badische Anilin- und Soda-Fabrik" (English: Baden Aniline and Soda Factory), now the largest chemical supplier, echoes the legacy of the synthetic dye industry, built via aniline dyes and extended via the related azo dyes. The first azo dye was aniline yellow. In the late 19th century, aniline emerged as an analgesic drug, its cardiac-suppressive side effects countered with caffeine. During the first decade of the 20th century, while trying to modify synthetic dyes to treat African sleeping sickness, Paul Ehrlich – who had coined the term "chemotherapy" for his "magic bullet" approach to
Aniline to 1.39 Å, indicating the -bonding between N and C. Industrial aniline production involves two steps. First, benzene is nitrated with a concentrated mixture of nitric acid and sulfuric acid at 50 to 60 °C to yield nitrobenzene. The nitrobenzene is then hydrogenated (typically at 200–300 °C) in the presence of metal catalysts: The reduction of nitrobenzene to aniline was first performed by Nikolay Zinin in 1842, using inorganic sulfide as a reductant (Zinin reaction). Aniline can alternatively be prepared from ammonia and phenol derived from the cumene process. In commerce, three brands of aniline are distinguished: aniline oil for