Chemical element or an electrophile; similarly "Nu" denotes a nucleophile. "L" is used to represent a general ligand in inorganic and organometallic chemistry. "M" is also often used in place of a general metal. At least two additional, two-letter generic chemical symbols are also in informal usage, "Ln" for any lanthanide element and "An" for any actinide element. "Rg" was formerly used for any rare gas element, but the group of rare gases has now been renamed noble gases and the symbol "Rg" has now been assigned to the element roentgenium. Isotopes are distinguished by the atomic mass number (total protons and
Chemical element plants, the calcium in mollusc shells, or the iron in the hemoglobin in vertebrate animals' red blood cells. The concept of an "element" as an undivisible substance has developed through three major historical phases: Classical definitions (such as those of the ancient Greeks), chemical definitions, and atomic definitions. Ancient philosophy posited a set of classical elements to explain observed patterns in nature. These "elements" originally referred to "earth", "water", "air" and "fire" rather than the chemical elements of modern science. The term 'elements' ("stoicheia") was first used by the Greek philosopher Plato in about 360 BCE in his dialogue Timaeus,