Diabetes mellitus type 1 Diabetes mellitus type 1 Diabetes mellitus type 1, also known as type 1 diabetes, is a form of diabetes mellitus in which very little or no insulin is produced by the pancreas. Before treatment this results in high blood sugar levels in the body. The classic symptoms are frequent urination, increased thirst, increased hunger, and weight loss. Additional symptoms may include blurry vision, feeling tired, and poor wound healing. Symptoms typically develop over a short period of time. The cause of type 1 diabetes is unknown. However, it is believed to involve a combination of genetic and environmental factors. Risk
Genetic causes of diabetes mellitus type 1 Genetic causes of diabetes mellitus type 1 At least 20 different chromosomal regions have been linked to type 1 diabetes (T1D) susceptibility in humans, using genome screening, candidate gene testing, and studies of human homologues of mouse susceptibility genes. The largest contribution to the pathogenesis of Type 1 Diabetes comes from a single locus called IDDM1, which comes from several genes located in the Major histocompatibility complex on the 6p21.3 chromosome. This is believed to be responsible for at least 40% of the disease's familial aggreagation. Additionally, nearly 30% of Type I Diabetes patients are heterozygous for several HLA-DQ2 (specifically