Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
Toe the line Toe the line "Toe the line" is an idiomatic expression meaning either to conform to a rule or standard, or to stand poised at the starting line in a footrace. Other phrases which were once used in the early 1800s and have the same meaning were toe the mark and toe the plank. The expression has disputed origins. Those suggested are from public school, the armed services, or possibly the British House of Commons. It is common practice in many long-established schools for roll-call to be taken twice a day, at which the pupils line up with their toes exactly