Epigenetics of diabetes Type 2 have shown that miRNAs have pivotal roles in many different gene regulatory pathways. A subset of miRNAs has been shown to be involved in metabolic regulation of glucose homeostasis and in epigenetics of diabetes type 2. Pancreatic islet-specific miR-375 inhibits insulin secretion in mouse pancreatic β-cells by inhibiting the expression of the protein myotrophin. An overexpression of miR-375 can completely suppress glucose-induced insulin secretion, while inhibition of native miR-375 will increase insulin secretion. In another study, increasing the level of miR-9, a different miRNA, resulted in a severe defect in glucose-stimulated insulin release. This happens because miR-9 down-regulated the transcription
Type 1 Diabetes Association Type 1 Diabetes Association The Type 1 Diabetes Association (T1DA) is a US nonprofit charity providing type 1 diabetes information, advocacy, and resources. The Type 1 Diabetes Association was founded in 2007 by Jon Strishak, a Type 1 diabetic marathon runner. The mission of the Type 1 Diabetes Association is to improve the quality of life for those living with type 1 diabetes. To fulfill this mission, the Type 1 Diabetes Association seeks to raises awareness of Type 1 diabetes issues by educating communities on related issues, encourages type 1 diabetics to live a more healthy and active lifestyle and