Dental amalgam controversy an increasing number of studies with larger sample sizes are being conducted. Those who are not opposed to amalgam claim that, aside from rare and localized tissue irritation, recent evidence-based research has continued to demonstrate no ill effects from the minute amounts of mercury exposure from amalgam fillings. A 2004 systematic review conducted by the Life Sciences Research Office, whose clients include the FDA and NIH, concluded that, "the current data are insufficient to support an association between mercury release from dental amalgam and the various complaints that have been attributed to this restoration material." A systematic review in 2009
Dental amalgam controversy removing toxic substances from the body, when such treatment is performed solely at the recommendation or suggestion of the dentist, is improper and unethical". Under the comments of the American Dental Association before the FDA's Dental Products Panel of the Medical Devices Advisory Committee, the ADA supports the 2009 FDA ruling on dental amalgam. ADA states that "dental amalgam has an established record of safety and effectiveness, which the scientific community has extensively reviewed and affirmed." The ADA also supports the 2017 EPA wastewater regulation and is providing information and assistance to its members in implementation of amalgam separators. The