Post-transition metal defined transition elements as finishing at group 10 (nickel, palladium and platinum), therefore excluding group 11 (copper, silver and gold), and group 12 (zinc, cadmium and mercury). A survey of chemistry books in 2003 showed that the transition metals ended at either group 11 or group 12 with roughly equal frequency. Where the post-transition metals end depends on where the metalloids or nonmetals start. Boron, silicon, germanium, arsenic, antimony and tellurium are commonly recognised as metalloids; other authors treat some or all of these elements as nonmetals. The diminished metallic nature of the post-transition metals is largely attributable to the
Germanium element for any living organism. Some complex organic germanium compounds are being investigated as possible pharmaceuticals, though none have yet proven successful. Similar to silicon and aluminum, natural germanium compounds tend to be insoluble in water and thus have little oral toxicity. However, synthetic soluble germanium salts are nephrotoxic, and synthetic chemically reactive germanium compounds with halogens and hydrogen are irritants and toxins. In his report on "The Periodic Law of the Chemical Elements" in 1869, the Russian chemist Dmitri Mendeleev predicted the existence of several unknown chemical elements, including one that would fill a gap in the carbon family