Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
Septic arthritis 1.1% of getting infected in knee joint, and 0.3 to 1.7% of getting infected in hip joint. There are three phases of artificial joint infection: early, delayed, and late. Septic arthritis is most commonly caused by bacteria reaching the synovial membrane of a joint. Bacteria can enter the joint by: Micro-organisms in the blood may come from infections elsewhere in the body such as wound infections, urinary tract infections, meningitis , or endocarditis. Sometimes the infection comes from an unknown location. Joints with preexisting arthritis, such as rheumatoid arthritis, are especially prone to bacterial arthritis spread through the blood. In