Structural rule A famous structural rule is known as cut. Considerable effort is spent by proof theorists in showing that cut rules are superfluous in various logics. More precisely, what is shown is that cut is only (in a sense) a tool for abbreviating proofs, and does not add to the theorems that can be proved. The successful 'removal' of cut rules, known as "cut elimination", is directly related to the philosophy of "computation as normalization" (see Curry–Howard correspondence); it often gives a good indication of the complexity of deciding a given logic. Structural rule In proof theory, a structural rule is
Lipinski's rule of five easier time in delivering optimized drug development candidates that are also drug-like. Hence the rule of five has been extended to the rule of three (RO3) for defining lead-like compounds. A rule of three compliant compound is defined as one that has: Lipinski's rule of five Lipinski's rule of five also known as the Pfizer's rule of five or simply the rule of five (RO5) is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would make it a likely orally active