Serum (blood) form of immunotherapy. Blood serum and plasma are some of the largest sources of biomarkers, whether for diagnostics or therapeutics. Its vast dynamic range, further complicated by the presence of lipids, salts, and post-translational modifications, as well multiple mechanisms of degradation, presents challenges in analytical reproducibility, sensitivity, resolution, and potential efficacy. For analysis of biomarkers in blood serum samples, it is possible to do a pre-separation by free-flow electrophoresis that usually consists of a depletion of serum albumin protein. This method enables greater penetration of the proteome via separation of a wide variety of charged or chargeable analytes, ranging from
Blood, Sweat & Tears (Blood, Sweat & Tears album) Blood, Sweat & Tears (Blood, Sweat & Tears album) Blood, Sweat & Tears is the second album by the band Blood, Sweat & Tears, released in 1968. It was commercially successful, rising to the top of the U.S. charts for a collective seven weeks and yielding three successive Top 5 singles. It received a Grammy Award for Album of the Year in 1970 and has been certified quadruple platinum by the RIAA with sales of more than four million units in the U.S. In Canada, it enjoyed four runs and altogether eight weeks at No. 1 on the "RPM" national