Serum sickness proteins to form immune complexes. These complexes precipitate, enter the walls of blood vessels, and activate the complement cascade, initiating an inflammatory response and consuming much of the available complement component 3 (C3). The result is a leukocytoclastic vasculitis. This results in hypocomplementemia, a low C3 level in serum. They can also cause more reactions resulting in typical symptoms of serum sickness. Serum sickness can be developed as a result of exposure to antibodies derived from animals. These sera or antitoxins are generally administered to prevent or treat an infection or envenomation. Some of the drugs associated with serum sickness
Blood, Sweat & Tears 4 Blood, Sweat & Tears 4 Blood, Sweat & Tears 4 is the fourth album by the band Blood, Sweat & Tears, released in 1971. It peaked at number 10 on the Billboard Pop albums chart. The band invited former member Al Kooper to contribute the song "John the Baptist (Holy John)." Trombonist Dave Bargeron replaced Jerry Hyman. David Clayton-Thomas left as lead vocalist to pursue a solo career after the release of "BS&T 4", as did founding members Dick Halligan and Fred Lipsius. Clayton-Thomas would return to the lineup for "New City". Writing for Allmusic, critic William Ruhlman wrote "the