Aquae Calidae, Bulgaria well as from Kabyle, Mesambria (now Nessebar), Odessos, Histria, Tomis, Byzantium, Abdera, Maroneia and the islands of the Aegean, the oldest from Apollonia Pontica from the 5th century BC. The first baths at the Sanctuary of the Three Nymphs originated when the Roman Empire under Lucullus conquered the region, during the Third Mithridatic War in 72 BC. Under Trajan (98-117) nearby Anchialos became the administrative centre of the region and the baths were expanded and extended with two more swimming pools. During this time the Via Pontica was built connecting Constantinople via Deultum, Anchialos, Aquae Calidae with Dorostorum and Sexaginta
Aphanizomenon flos-aquae it had a profound effect on natural killer cells (NKCs). "A. flos-aquae" triggers the movement of 40% of the circulating NKCs from the blood to tissues. Some compressed tablets of powdered "A. flos-aquae" cyanobacteria (named as "blue green algae") have been sold as food supplements, notably those filtered from Upper Klamath Lake in Oregon. Aphanizomenon flos-aquae Aphanizomenon flos-aquae is a brackish and freshwater species of cyanobacteria found around the world, including the Baltic Sea and the Great Lakes. "Aphanizomenon flos-aquae" can form dense surface aggregations in freshwater (known as "cyanobacterial blooms"). These blooms occur in areas of high nutrient loading,