Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
Toe to Toe Toe to Toe Toe to Toe are an Australian hardcore band from Sydney, New South Wales, Australia. The band was most prominent in the Australian hardcore scene during the 1990s, touring and recording less frequently by the 2000s. They have been described as "one of the best hardcore outfits ever to grace the planet" by "Punknews.org". Toe to Toe's stated aim is "to reintroduce the sounds and ethics of 80's hardcore punk", having been influenced by the emergence of the Washington, D.C. hardcore band Bad Brains, Portland hardcore band Poison Idea and later, New York hardcore bands such as Agnostic