Cobalt chelatase Cobalt chelatase Cobalt chelatase () is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are ATP, hydrogenobyrinic acid a,c-diamide, Co, and HO, whereas its 4 products are ADP, phosphate, cob(II)yrinic acid a,c-diamide, and H. The aerobic cobalt chelatase (aerobic cobalamin biosynthesis pathway) consists of three subunits, CobT, CobN () and CobS (). Cobalamin (vitamin B12) can be complexed with metal via the ATP-dependent reactions (aerobic pathway) (e.g., in "Pseudomonas denitrificans") or via ATP-independent reactions (anaerobic pathway) (e.g., in "Salmonella typhimurium"). The corresponding cobalt chelatases are not homologous. However, aerobic cobalt chelatase subunits CobN and CobS
Period 4 element in period 4, between chromium and iron. Manganese is often found free in nature, but is also found in combination with iron. Manganese, like chromium before it, is an important component in stainless steel, preventing the iron from rusting. Manganese is also often used in pigments, again like chromium. Manganese is also poisonous; if enough is inhaled, it can cause irreversible neurological damage. Iron (Fe) is an element in period 4, between manganese and cobalt. Iron is probably the most well-known element in period 4, being the most common element in the earth and a major component of steel. Iron-56