Dental amalgam controversy demonstrated that mercury released from amalgam restorations does not give rise to toxic effects on the nervous system of children. More recently, a Cochrane Systematic review in 2014 found, "insufficient evidence to support or refute any adverse effects associated with amalgam or composite restorations." Those opposed to dental amalgam suggest that mercury from dental amalgam may lead to nephrotoxicity, neurobehavioural changes, autoimmunity, oxidative stress, autism, skin and mucosa alterations, non-specific symptoms and complaints, Alzheimer's disease, and multiple sclerosis. Both those opposed and those not opposed to dental amalgam recognize that amalgam has been found to be a rare contributor to
Amalgam Digital in hip hop music and distribution. In an April 2008 issue, "The Source" proclaimed that Amalgam Digital has "its finger on the pulse of hip-hop's future." Based in East Boston, the Amalgam Digital label is distributed exclusively by Amalgam Entertainment LLC, a distribution company that offers management, marketing, and promotional services. As an independent label, Amalgam Digital been home to such artists as Max B, Saigon, Curren$y, Chuuwee, Joe Budden, Peedi Crakk, Tash, Kurious, Juggaknots, Tame One, and Lil B. Joe Budden's album released by the label, "Padded Room", reached #42 in the "Billboard" 200 chart and #21 in the