Windows Communication Foundation what communication protocols are used to access the service, whether security mechanisms are to be used, and the like. WCF includes predefined bindings for most common communication protocols such as SOAP over HTTP, SOAP over TCP, and SOAP over Message Queues, etc. Interaction between WCF endpoint and client is done using a SOAP envelope. SOAP envelopes are in simple XML form, which makes WCF platform-independent. When a client wants to access the service via an endpoint, it not only needs to know the contract, but it also has to adhere to the binding specified by the endpoint. Thus, both client
Proof of concept Proof of Principle or PoP relates to early clinical development and typically refers to an evaluation of the effect of a new treatment on disease biomarkers, but not the clinical endpoints of the condition. Early stage clinical trials may aim to demonstrate Proof of Mechanism, or Proof of Principle, or both. A decision is made at this point as to whether to progress the drug into later development, or if it should be dropped. Proof of Concept PoC refers to early clinical drug development, conventionally divided into "Phase I" and "Phase IIa". "Phase I" is typically conducted with 10 to