Rule 34 (novel) revelations by Edward Snowden, Stross announced that there would be no third book in the planned trilogy. ""Halting State" wasn't intended to be predictive when I started writing it in 2006. Trouble is, about the only parts that haven't happened yet are Scottish Independence and the use of actual quantum computers for cracking public key encryption (and there's a big fat question mark over the latter—what else are the NSA up to?)" Rule 34 (novel) Rule 34 is a near-future science fiction novel by Charles Stross. It is a loose sequel to "Halting State", and was released on 5 July
Lipinski's rule of five easier time in delivering optimized drug development candidates that are also drug-like. Hence the rule of five has been extended to the rule of three (RO3) for defining lead-like compounds. A rule of three compliant compound is defined as one that has: Lipinski's rule of five Lipinski's rule of five also known as the Pfizer's rule of five or simply the rule of five (RO5) is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would make it a likely orally active