Diabetes and Inflammation Laboratory members include:- Diabetes and Inflammation Laboratory The JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/WT DIL), centred in the Cambridge Institute for Medical Research, is a multi-disciplinary research programme within the department of Medical Genetics at the University of Cambridge. The current director is John Todd FMedSci FRS and Professor of Medical Genetics at the University of Cambridge. The goals of the JDRF/WT DIL are to identify and characterise the effects of the susceptibility genes for type 1 diabetes in order to better understand the earliest events in human physiology that lead to autoimmune destruction of the insulin-producing beta-cells of pancreas.
Epigenetics of diabetes Type 2 obtained from Diabetes mellitus type 1 and Diabetes type 2 patients was seen. Acetylation at these promoters increases gene expression and increases the inflammatory response as a result. Genome-wide location studies using chromatin immunoprecipitation (ChIP) coupled with DNA microarray analysis revealed significant changes in H3K4me2 and H3K9me2 patterns at key gene regions in high glucose-treated THP-1 monocytes, with relevant changes being observed in primary monocytes from diabetes patients. A possible treatment for vascular complications of diabetes exists with the SIRT1 gene, a member of Sirtuin family of genes. The SIRT1 enzyme has HDAC activity, and has been shown to modulate