Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
The Big Toe Radio Show The Big Toe Radio Show The Big Toe Radio Show was a daily show (seven days a week) for children on the DAB radio station BBC 7 at breakfast time and from 4 to 6pm. It was aimed at children aged nine to eleven. It featured music, games, stories read from well-known books such as those by Roald Dahl and fun. It began in December 2002, as BBC 7 launched A notable feature was the involvement of children in the making of the programme. Each day, three children were invited to the specially-designed studios at Broadcasting House. Becoming part of