Hyperkalemia Hyperkalemia may only become apparent when a person's platelet concentration is more than 500,000/microL in a clotted blood sample (serum blood sample). Potassium leaks out of platelets after clotting has occurred. On the other hand, processing of heparinised, unclot blood does not cause falsely elevated potassium. In addition to that, high white cell count (greater than 120,000/microL) in patient with chronic lymphocytic leukemia increases red blood cells fragility, thus causing pseudohyperkalemia during blood processing. This problem can be avoided by processing serum samples, because formation of clot protect the cells from haemolysis during processing. A familial form of pseudohyperkalemia may
Ebola virus disease causes swelling and shock due to loss of blood volume. The dysfunctional bleeding and clotting commonly seen in EVD has been attributed to increased activation of the extrinsic pathway of the coagulation cascade due to excessive tissue factor production by macrophages and monocytes. After infection, a secreted glycoprotein, small soluble glycoprotein (sGP or GP) is synthesized. EBOV replication overwhelms protein synthesis of infected cells and the host immune defenses. The GP forms a trimeric complex, which tethers the virus to the endothelial cells. The sGP forms a dimeric protein that interferes with the signaling of neutrophils, another type of white