Arthritis and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism. Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it
The Big Toe Radio Show the Big Toe team for the day, the children could see the 'behind-the-scenes' aspects of making a radio programme. If they wished to, they could also take part in the on-air features, often having the opportunity of interviewing visiting guests such as musicians, authors, scientists, and sports stars. Its counterpart was the hour-long Little Toe Radio Show for children beginning school of age four to seven, which was broadcast daily at 7am and 3pm. In 2003, the Big Toe Reporters' Club was formed where children reported on current affairs pertaining to them – often very different from topics found on