Serum (blood) form of immunotherapy. Blood serum and plasma are some of the largest sources of biomarkers, whether for diagnostics or therapeutics. Its vast dynamic range, further complicated by the presence of lipids, salts, and post-translational modifications, as well multiple mechanisms of degradation, presents challenges in analytical reproducibility, sensitivity, resolution, and potential efficacy. For analysis of biomarkers in blood serum samples, it is possible to do a pre-separation by free-flow electrophoresis that usually consists of a depletion of serum albumin protein. This method enables greater penetration of the proteome via separation of a wide variety of charged or chargeable analytes, ranging from
Blood, Sweat & Tools Blood, Sweat & Tools Blood, Sweat & Tools is a Canadian television series broadcast on Discovery Channel. The series is hosted by Helder Brum, Rob Koci and Hillary Manion, who also act as the challenge judges and expert advisers to the contestants. The series is the successor of "Canada's Worst Handyman", and has a broadly similar format, but with an emphasis on rewarding competent handiwork rather than finding the nation's worst handyman. The couples are divided into teams, who are each tasked with undertaking a number of handiwork-related challenges, with the overall goal of improving their skills and confidence. At