Lumbar fascia Lumbar fascia The lumbar fascia is an anatomic structure of the lumbar region. It consists of a band or sheet of connective tissue fibres, primarily collagen, that attaches, stabilizes, encloses and separates muscles not limited to the lumbar region as the name suggests, but extending upwards over the thorax to the neck and downwards over the muscles covering the sacrum. The upper thoracic portion is thin while the lumbar and sacral regions are thicker and stronger. The lumbar fascia binds the deep muscles of the back to the spine and to the transverse processes of the vertebrae. Additionally the lumbar
Collagen, type XVII, alpha 1 of laminin 5 into the matrix requires collagen XVII. Mutations in the human collagen XVII gene, , lead to the absence or structural alterations and mutations of collagen XVII. The functional consequences include diminished epidermal adhesion and skin blistering in response to minimal shearing forces. The disorder caused by biallelic COL17A1 mutations and is called junctional epidermolysis bullosa, an autosomal recessive skin disease with variable clinical phenotypes. Morphological characteristics of junctional epidermolysis bullosa are rudimentary hemidesmosomes and subepidermal tissue separation. Clinical hallmarks, in addition to blisters and erosions of the skin and mucous membranes, include nail dystrophy, loss of hair,