Serum sickness proteins to form immune complexes. These complexes precipitate, enter the walls of blood vessels, and activate the complement cascade, initiating an inflammatory response and consuming much of the available complement component 3 (C3). The result is a leukocytoclastic vasculitis. This results in hypocomplementemia, a low C3 level in serum. They can also cause more reactions resulting in typical symptoms of serum sickness. Serum sickness can be developed as a result of exposure to antibodies derived from animals. These sera or antitoxins are generally administered to prevent or treat an infection or envenomation. Some of the drugs associated with serum sickness
Blood, toil, tears, and sweat Blood, toil, tears, and sweat The phrase "blood, toil, tears and sweat" became famous in a speech given by Winston Churchill to the House of Commons of the Parliament of the United Kingdom on 13 May 1940. This was Churchill's first speech on 13 May 1940 to the House of Commons after having been offered the King's commission the previous Friday, to become Prime Minister of the United Kingdom in the first year of World War II. Churchill had replaced Neville Chamberlain on 10 May, and in this speech he asked the House to declare its confidence in his Government.