Matzo must be ground from one of the five grains specified in Jewish law for Passover matzo: wheat, barley, spelt, rye or oat. Per Ashkenazic tradition, matzo made with wine, fruit juice, onion, garlic, etc., is not acceptable for use at any time during the Passover festival except by the elderly or unwell. Matzo dough is quickly mixed and rolled out without an autolyse step as used for leavened breads. Most forms are pricked with a fork or a similar tool to keep the finished product from puffing up, and the resulting flat piece of dough is cooked at high temperature
Meta-selective C–H functionalization copper catalyzed C–H arylation. "Meta"-olefinated biologically important biphenyl, amino acid and Baclofen derivatives have been accessed by remote C–H activation assisted by the "end-on" template. These demonstrate the potential applications of meta-selective C–H functionalization in medicinal chemistry. Meta-selective C–H functionalization "Meta"-selective C–H functionalization refers to the regioselective reaction of a substituted aromatic ring on the C–H bond "meta" to the substituent. Substituted aromatic ring is an important type of substructure in pharmaceuticals and industrial compounds. Thus, synthetic methods towards substituted aromatic rings are always of great interest to chemists. Traditionally, regioselectivity on the aromatic ring is achieved by the electronic