Diabetes and Inflammation Laboratory members include:- Diabetes and Inflammation Laboratory The JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/WT DIL), centred in the Cambridge Institute for Medical Research, is a multi-disciplinary research programme within the department of Medical Genetics at the University of Cambridge. The current director is John Todd FMedSci FRS and Professor of Medical Genetics at the University of Cambridge. The goals of the JDRF/WT DIL are to identify and characterise the effects of the susceptibility genes for type 1 diabetes in order to better understand the earliest events in human physiology that lead to autoimmune destruction of the insulin-producing beta-cells of pancreas.
Epigenetics of diabetes Type 2 in patients with Type 2 Diabetes is retinopathy which causes many patients to go blind. Studies showed that retinal damage persisted even after the reversal of hyperglycemia in dogs. Studies with streptozotocin injected Type 1 diabetes rats showed that the re-institution of glycemic control after a short period of hyperglycemia had protective effects in the eyes, including reduction in parameters of oxidant stress and inflammation. However, specimens with prolonged diabetes failed to show similar protection. It was then seen with endothelial cells (which line blood vessels) cultured in high glucose that there was a sustained increase in the expression of