Cobalt a structural analog to ferrocene, with cobalt in place of iron. Cobaltocene is much more sensitive to oxidation than ferrocene. Cobalt carbonyl (Co(CO)) is a catalyst in carbonylation and hydrosilylation reactions. Vitamin B (see below) is an organometallic compound found in nature and is the only vitamin that contains a metal atom. An example of an alkylcobalt complex in the otherwise uncommon +4 oxidation state of cobalt is the homoleptic complex (Co(1-norb)), a transition metal-alkyl complex that is notable for its stability to β-hydrogen elimination. The cobalt(III) and cobalt(V) complexes [Li(THF)][Co(1-norb)] and [Co(1-norb)][BF] are also known. Co is the only
Cobalt aminopeptidase 2, an enzyme that occurs in humans and other mammals that does not use the corrin ring of B, but binds cobalt directly. Another non-corrin cobalt enzyme is nitrile hydratase, an enzyme in bacteria that metabolizes nitriles. Cobalt is an essential element for life in minute amounts. The LD value for soluble cobalt salts has been estimated to be between 150 and 500 mg/kg. In the US, the Occupational Safety and Health Administration (OSHA) has designated a permissible exposure limit (PEL) in the workplace as a time-weighted average (TWA) of 0.1 mg/m. The National Institute for Occupational Safety and