Matzo produce is completely permissible for consumption during Passover, whether or not made according to the laws applying to matzot. As a result, Joseph ben Ephraim Karo, author of the "Shulchan Aruch" or "Code of Jewish Law" (Orach Chayim 462:4) granted blanket permission for the use of any matzo made from non-water-based dough, including egg matzo, on Passover. Many egg matzo boxes no longer include the message, "Ashkenazi custom is that egg matzo is only allowed for children, elderly and the infirm during Passover." Even amongst those who consider that enriched matzot may not be "eaten" during Passover, it is permissible
Meta-selective C–H functionalization copper catalyzed C–H arylation. "Meta"-olefinated biologically important biphenyl, amino acid and Baclofen derivatives have been accessed by remote C–H activation assisted by the "end-on" template. These demonstrate the potential applications of meta-selective C–H functionalization in medicinal chemistry. Meta-selective C–H functionalization "Meta"-selective C–H functionalization refers to the regioselective reaction of a substituted aromatic ring on the C–H bond "meta" to the substituent. Substituted aromatic ring is an important type of substructure in pharmaceuticals and industrial compounds. Thus, synthetic methods towards substituted aromatic rings are always of great interest to chemists. Traditionally, regioselectivity on the aromatic ring is achieved by the electronic