Serum (blood) form of immunotherapy. Blood serum and plasma are some of the largest sources of biomarkers, whether for diagnostics or therapeutics. Its vast dynamic range, further complicated by the presence of lipids, salts, and post-translational modifications, as well multiple mechanisms of degradation, presents challenges in analytical reproducibility, sensitivity, resolution, and potential efficacy. For analysis of biomarkers in blood serum samples, it is possible to do a pre-separation by free-flow electrophoresis that usually consists of a depletion of serum albumin protein. This method enables greater penetration of the proteome via separation of a wide variety of charged or chargeable analytes, ranging from
Angiocrine growth factors Angiocrine growth factors Angiocrine growth factors are molecules found in blood vessels' endothelial cells that can stimulate organ-specific repair activities in damaged or diseased organs. Endothelial cells possess tissue-specific genes that code for unique growth factors, adhesion molecules and factors regulating metabolism. The discovery emerged after the entirety of active genes in endothelial cells was decoded, resulting in an atlas of organ-specific blood vessel cells. The atlas documented hundreds of already-known genes that had never been associated with these cells. Organs dictate the structure and function of their own blood vessels, including the repair molecules they secrete. Each organ produces