Peripheral edema condition. Successful treatment depends on control of the underlying cause. Severe swelling can cause permanent damage to nerves, resulting in peripheral neuropathy. Many cases from temporary or minor causes resolve on their own, with no lasting damage. Peripheral edema Peripheral edema is edema (accumulation of fluid causing swelling) in tissues perfused by the peripheral vascular system, usually in the lower limbs. In the most dependent parts of the body (those hanging distally), it may be called dependent edema. The condition is commonly associated with aging, but can be caused by many other conditions, including congestive heart failure, renal failure, liver
Tissue residue the exposure media. In general, tissue residue approaches are used for chemicals that bioaccumulate or for bioaccumulative chemicals. The majority of these substances are organic compounds that are not easily metabolized by organisms and have long environmental persistence. Examples of these chemicals include: polychlorinated dibenzodioxins, furans, biphenyls, DDT and its metabolites, and dieldrin. The use of tissue residues in assessing toxicity and bioaccumulation may also be referred to as the tissue residue-effects approach (TRA), critical body residue (CBR) or tissue residue-based toxicity tests. Historically, aquatic toxicology toxicity tests have focused on water-based approaches where concentration of a toxicant is determined