Escapement each time it filled up, thus advancing the clock's wheels each time an equal quantity of water was measured out. The time between releases depended on the rate of flow, which decreased with water pressure as the level of water in the source container dropped. The development of mechanical clocks depended on the invention of an escapement which would allow a clock's movement to be controlled by an oscillating weight. Unlike the continuous flow of water in the Chinese device, the medieval escapement was characterized by a regular, repeating sequence of discrete actions and the capability of self-reversing action: Both
Controlled internal drug release Controlled internal drug release Controlled internal drug release (CIDR) devices are used in livestock for the synchronization of estrus. They are T-shaped devices with a silicone-coated nylon core. The silicone coating is impregnated with progesterone. CIDRs are inserted intra-vaginally using a specialized applicator. The flexible wings collapse for facilitated insertion and expand once placed appropriately within the vagina. The expansion of the wings retains its position; CIDRs have very high retention rates that may exceed 97%. A thin nylon tail remains exteriorized and is used for removal. Once inserted, CIDRs provide slow-release administration of progesterone, which artificially extends the luteal