Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Effects of parasitic worms on the immune system fight because it's just a waste of time." In the scientific journal "Immunology", Rook states that, because parasitic worms were almost always present, the human immune system developed a way to treat them that didn't cause tissue damage. The immune system extends this response to its treatments of self-antigens, softening reactions against allergens, the body, and digestive microorganisms. As the worms developed ways of triggering a beneficial immune response, humans came to rely on parasitic interaction to help regulate their immune systems. As developed countries advanced in technology, medicine, and sanitation, parasitic worms were mostly eradicated in those countries, according