Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract Hospital Pontefract Hospital Pontefract Hospital is an acute District General Hospital in Pontefract, West Yorkshire operated by the Mid Yorkshire Hospitals NHS Trust. The original hospital in Pontefract was the Pontefract Dispensary which was established in Sessions House Yard in 1812. The foundation stone for a new hospital in Southgate was laid by Hugh Childers, Secretary of State for War on 7 May 1880; it was opened by John Rhodes, the Mayor of Wakefield, on 8 December 1880. The facility became Pontefract General Infirmary on the formation of the National Health Service in 1948. A new hospital, to be known as