Verge escapement Verge escapement The verge (or crown wheel) escapement is the earliest known type of mechanical escapement, the mechanism in a mechanical clock that controls its rate by allowing the gear train to advance at regular intervals or 'ticks'. Its origin is unknown. Verge escapements were used from the 14th century until the mid 19th century in clocks and pocketwatches. The name verge comes from the Latin "virga", meaning stick or rod. Its invention is important in the history of technology, because it made possible the development of all-mechanical clocks. This caused a shift from measuring time by continuous processes, such
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems