Liquorice or loss, and hypertension. The United States Food and Drug Administration believes that foods containing liquorice and its derivatives (including glycyrrhizin) are safe if not consumed excessively. Other jurisdictions have suggested no more than 100 mg to 200 mg of glycyrrhizin per day, the equivalent of about of liquorice. Liquorice should not be used during pregnancy. Liiquorice is an extract from the "Glycyrrhiza glabra" plant which contains glycyrrhizic acid, or GZA. GZA is made of one molecule of glycyrrhetinic acid and two molecules of glucuronic acid. The extracts from the root of the plant can also be referred to as
Glycyrrhizin glycyrrhizin is first hydrolysed to 18β-glycyrrhetinic acid (enoxolone) by intestinal bacteria. After complete absorption from the gut, 18β-glycyrrhetinic acid is metabolised to 3β-monoglucuronyl-18β-glycyrrhetinic acid in the liver. This metabolite then circulates in the bloodstream. Consequently, its oral bioavailability is poor. The main part is eliminated by bile and only a minor part (0.31–0.67%) by urine. After oral ingestion of 600 mg of glycyrrhizin the metabolite appeared in urine after 1.5 to 14 hours. Maximal concentrations (0.49 to 2.69 mg/l) were achieved after 1.5 to 39 hours and metabolite can be detected in the urine after 2 to 4 days. Glycyrrhizin