Mass in special relativity what causes these particles to be termed "massless." However, even massless particles have a relativistic mass, which varies with their observed energy in various frames of reference, The invariant mass is the ratio of four-momentum (the four-dimensional generalization of classical momentum) to four-velocity: and is also the ratio of four-acceleration to four-force when the rest mass is constant. The four-dimensional form of Newton's second law is: The relativistic expressions for "E" and "p" obey the relativistic energy–momentum relation: where the m is the rest mass, or the invariant mass for systems, and "E" is the total energy. The equation is
Rank product determine how likely a given RP value or better is observed in a random experiment. Permutation re-sampling requires a computationally demanding number of permutations to get reliable estimates of the "p"-values for the most differentially expressed genes, if "n" is large. Eisinga, Breitling and Heskes (2013) provide the exact probability mass distribution of the rank product statistic. Calculation of the exact "p"-values offers a substantial improvement over permutation approximation, most significantly for that part of the distribution rank product analysis is most interested in, i.e., the thin right tail. However, exact statistical significance of large rank products may take unacceptable