Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract of two distinct and separate localities known as Tanshelf and Kirkby. The 11th-century historian, Orderic Vitalis, recorded that, in 1069, William the Conqueror travelled across Yorkshire to put down an uprising which had sacked York, but that, upon his journey to the city, he discovered that the crossing of the River Aire at what is modern-day Pontefract had been blockaded by a group of local Anglo-Scandinavian insurgents, who had broken the bridge and held the opposite bank in force. Such a crossing point would have been important in the town's early days, providing access between Pontefract and other settlements to