Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Avian immune system such as the availability of many embryos at precise stages of development and distinct B and T cell systems. Each population differentiates from a primary lymphoid organ: T cells in the thymus and B cells in the Bursa of Fabricius. Research has found that early feeding of hydrated nutritional supplements in chickens heavily affects the immune system development. This is often measured by weight of the Bursa of Fabricius, improved resistance to disease and earlier appearance of IgA. Unlike other animals, newly hatched chicks are born with an incomplete immune system. Here, the amniotic fluid and yolk of the egg