Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Wolf attack Wolf attack Although wolf attacks do occur, their frequency varies with geographical location and historical period. Gray wolf attacks are rare because wolves are often subsequently killed, or even extirpated in reaction by human beings. As a result, wolves today tend to live mostly far from people or have developed the tendency and ability to avoid them. The country with the most extensive historical records is France, where nearly 7,600 fatal attacks were documented from 1200 to 1920. In modern times, they occur most often in India and neighboring countries. There are few historical records or modern cases of wolf