Polypodium glycyrrhiza have random placement, originating at various points. The rhizome appears reddish-brown, and is a sweet licorice-flavored. The name "glycyrrhiza" refers to this flavor--"glykys" in Greek means sweet, with "rhiza" meaning root. Since it is a fern, "P. glycyrrhiza" reproduces by spores; the spores grow in a pattern of spots on the undersides of the leaves. These sori may be oval in immaturity. Licorice fern may grow over the ground, rocks, or as an epiphyte. The plant prefers moist environments, so it is typically found on wet ground, rocks, and logs. Occasionally it can be seen on fallen trees. It is
Glycyrrhizin glycyrrhizin is first hydrolysed to 18β-glycyrrhetinic acid (enoxolone) by intestinal bacteria. After complete absorption from the gut, 18β-glycyrrhetinic acid is metabolised to 3β-monoglucuronyl-18β-glycyrrhetinic acid in the liver. This metabolite then circulates in the bloodstream. Consequently, its oral bioavailability is poor. The main part is eliminated by bile and only a minor part (0.31–0.67%) by urine. After oral ingestion of 600 mg of glycyrrhizin the metabolite appeared in urine after 1.5 to 14 hours. Maximal concentrations (0.49 to 2.69 mg/l) were achieved after 1.5 to 39 hours and metabolite can be detected in the urine after 2 to 4 days. Glycyrrhizin