Escapement and watches. These are described individually below. Although the invention of the crystal oscillator and the quartz clock in the 1920s shifted technological research in timekeeping to electronic methods, major advances in the design of mechanical escapement are still happening. Coaxial escapement, invented by English watchmaker George Daniels around 1974 and patented in 1980 has rather dramatically increased the accuracy and durability of mechanical watches. Yoshikazu Akahane with teams of engineers at Seiko Epson developed the spring drive movement around 1977, and obtained not less than 230 patents between 1982 and the present. The reliability of an escapement depends on
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems