Escapement each time it filled up, thus advancing the clock's wheels each time an equal quantity of water was measured out. The time between releases depended on the rate of flow, which decreased with water pressure as the level of water in the source container dropped. The development of mechanical clocks depended on the invention of an escapement which would allow a clock's movement to be controlled by an oscillating weight. Unlike the continuous flow of water in the Chinese device, the medieval escapement was characterized by a regular, repeating sequence of discrete actions and the capability of self-reversing action: Both
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a