Collagen evolution of collagens was a fundamental step in the early evolution of life, supporting the coalescence of multicellular life forms. Collagen D-banding is viable as periodic formation of ridging on all fibrils forming collagen. D-bands are created due to the semi-crystalline formation of the collagen within the fibrils. The pattern exhibited by D-banding is consistently independent of fibril diameter. When undergoing deformation, collagen fibrils may lose their D-banding, making the disappearance of the d-bands an indicator of the type of damage undergone by then tendon fibrils. Collagen Collagen is the main structural protein in the extracellular space in the various
Extracellular matrix exist in varying degrees of stiffness and elasticity, from soft brain tissues to hard bone tissues. The elasticity of the ECM can differ by several orders of magnitude. This property is primarily dependent on collagen and elastin concentration, and it has recently been shown to play an influential role in regulating numerous cell functions. Cells can sense the mechanical properties of their environment by applying forces and measuring the resulting backlash. This plays an important role because it helps regulate many important cellular processes including cellular contraction, cell migration, cell proliferation, differentiation and cell death (apoptosis). Inhibition of nonmuscle myosin