Polypodium glycyrrhiza a licorice-flavored tea. It may be used as a medicine for colds and respiratory conditions by indigenous peoples. It is considered an important medical plant and may have been used similar to cough drops. Since the rhizome is so sweet even in its naturally occurring state, and since the chemical is not a saccharide, it is possible that this compound could be used as a natural alternative to traditional sweeteners. Polypodium glycyrrhiza Polypodium glycyrrhiza, commonly known as licorice fern, many-footed fern, and sweet root, is a summer deciduous fern native to western North America, primarily in a narrow strip in
Glycyrrhizin glycyrrhizin is first hydrolysed to 18β-glycyrrhetinic acid (enoxolone) by intestinal bacteria. After complete absorption from the gut, 18β-glycyrrhetinic acid is metabolised to 3β-monoglucuronyl-18β-glycyrrhetinic acid in the liver. This metabolite then circulates in the bloodstream. Consequently, its oral bioavailability is poor. The main part is eliminated by bile and only a minor part (0.31–0.67%) by urine. After oral ingestion of 600 mg of glycyrrhizin the metabolite appeared in urine after 1.5 to 14 hours. Maximal concentrations (0.49 to 2.69 mg/l) were achieved after 1.5 to 39 hours and metabolite can be detected in the urine after 2 to 4 days. Glycyrrhizin