Line in the sand match of the 2009 season, with the two sides battling for eighth place on the ladder, a brawl was sparked by a remonstration from a head-high shirtfront from Essendon captain Matthew Lloyd on Hawthorn midfielder Brad Sewell at the start of the third quarter, which was to be the turning point in the match. Essendon won by 17 points after trailing by 22 points at the time of the Lloyd-Sewell incident. Line in the sand match The line in the sand match is the unofficial title given to the round 11, 2004 match between Australian Football League (AFL) clubs and ,
Allotopic expression Allotopic expression Allotopic expression (AE) refers to expression of genes in the cell nucleus that normally are expressed only from the mitochondrial genome. Biomedically engineered AE has been suggested as a possible future tool in gene therapy of certain mitochondria-related diseases, however this view is controversial. While this type of expression has been successfully carried out in yeast, the results in mammals have been conflicting. Gensight Biologics are currently pursuing a clinical program of expressing the ND4 gene in the nucleus to prevent retinal disease. The SENS Research Foundation recently reported success in expressing the ATP6 gene allotopically in vitro.