Mechanical engineering with differential gears. The medieval Chinese horologist and engineer Su Song (1020–1101 AD) incorporated an escapement mechanism into his astronomical clock tower two centuries before escapement devices were found in medieval European clocks. He also invented the world's first known endless power-transmitting chain drive. During the Islamic Golden Age (7th to 15th century), Muslim inventors made remarkable contributions in the field of mechanical technology. Al-Jazari, who was one of them, wrote his famous "Book of Knowledge of Ingenious Mechanical Devices" in 1206 and presented many mechanical designs. Al-Jazari is also the first known person to create devices such as the
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems