Escapement spring made accurate timepieces possible, it has been estimated that more than three hundred different mechanical escapements have been devised, but only about 10 have seen widespread use. These are described below. In the 20th century, electric timekeeping methods replaced mechanical clocks and watches, so escapement design became a little-known curiosity. The earliest mechanical escapement from about 1275) was the verge escapement, also known as the crown-wheel escapement. It was used in the first mechanical clocks and was originally controlled by a foliot, a horizontal bar with weights at either end. The escapement consists of an escape wheel shaped somewhat
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems