Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Behavioral immune system prototypical human being. The disease–avoidant processes that characterize the behavioral immune system have been shown to contribute to prejudices against obese individuals, elderly individuals, and people with physical disfigurements or disabilities. In addition, the behavioral immune system appears to contribute to xenophobia and ethnocentrism. One implication is that these prejudices tend to be exaggerated under conditions in which people feel especially vulnerable to the potential transmission of infectious diseases. Additional lines of research on the behavioral immune system have shown that people engage in more reticent and conservative forms of behavior under conditions in which they feel more vulnerable to