Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
In the Sweet By-and-By horns, harps, and other horrors, opened the proceedings with what seemed to be the crude first-draft or original agony of the wail known to later centuries as "In the Sweet Bye and Bye." It was new, and ought to have been rehearsed a little more. For some reason or other the queen had the composer hanged, after dinner. The hymn was parodied by Joe Hill in 1911 as "The Preacher and the Slave", in which the phrase "pie in the sky" was coined as a satirical comment on the Christian conception of heavenly reward. A parody of the song was