Verge escapement be mechanical, depending on which manuscript evidence they regard as conclusive. One candidate is the Dunstable Priory clock in Bedfordshire, England built in 1283, because accounts say it was installed above the rood screen, where it would be difficult to replenish the water needed for a water clock. Another is the clock built at the Palace of the Visconti, Milan, Italy, in 1335. However, there is agreement that mechanical clocks existed by the late 13th century. The earliest description of an escapement, in Richard of Wallingford's 1327 manuscript "Tractatus Horologii Astronomici" on the clock he built at the Abbey of
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems