Escapement Chinese escapement spread west and was the source for Western escapement technology. According to Ahmad Y. Hassan, a mercury escapement in a Spanish work for Alfonso X in 1277 can be traced back to earlier Arabic sources. Knowledge of these mercury escapements may have spread through Europe with translations of Arabic and Spanish texts. However, none of these were true mechanical escapements, since they still depended on the flow of liquid through an orifice to measure time. For example, in Su Song's clock, water flowed into a container on a pivot. The escapement's role was to tip the container over
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems