Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Wolf attack Wolf attack Although wolf attacks do occur, their frequency varies with geographical location and historical period. Gray wolf attacks are rare because wolves are often subsequently killed, or even extirpated in reaction by human beings. As a result, wolves today tend to live mostly far from people or have developed the tendency and ability to avoid them. The country with the most extensive historical records is France, where nearly 7,600 fatal attacks were documented from 1200 to 1920. In modern times, they occur most often in India and neighboring countries. There are few historical records or modern cases of wolf