Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Wolf attack pro-wolf lobby aiming to change public attitudes towards wolves, with the phrase “there has never been a documented case of a healthy wild wolf attacking a human in North America” (or variations thereof) becoming a slogan for people seeking to create a more positive image for the wolf. Although several non-fatal attacks had been reported since 1985, it was not until April 26, 2000 when a 6-year-old boy survived an attack by a wolf in Icy Bay, Alaska that the assumption that healthy wild wolves were harmless became seriously challenged. The event was considered so unusual that it was reported