Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Teenage Dream: The Complete Confection The Complete Confection" was met with generally mixed reviews from music critics, who were ambivalent towards the new songs' production and questioned the decision to reissue "Teenage Dream". As an independent release, the reissue reached the top ten in Australia, New Zealand, the United Kingdom and the United States. It has sold more than two million copies globally. Two singles were released from "Teenage Dream: The Complete Confection". The lead single, "Part of Me", debuted at number one on the U.S. "Billboard" Hot 100, and was eventually certified double-platinum by the Recording Industry Association of America (RIAA), while the second