Molecular mass Molecular mass Relative molecular mass or molecular weight is the mass of a molecule. It is calculated as the sum of the relative atomic masses of each constituent element multiplied by the number of atoms of that element in the molecular formula. The molecular mass of small to medium size molecules, measured by mass spectrometry, determines stoichiometry. For large molecules such as proteins, methods based on viscosity and light-scattering can be used to determine molecular mass when crystallographic data are not available. Both atomic and molecular masses are usually obtained relative to the mass of the isotope C (carbon 12),
Isotope neutron number to atomic number varies the most between isotopes it usually has only a small effect, although it does matter in some circumstances (for hydrogen, the lightest element, the isotope effect is large enough to strongly affect biology). The term "isotopes" (originally also "isotopic elements", now sometimes "isotopic nuclides") is intended to imply comparison (like "synonyms" or "isomers"), for example: the nuclides , , are isotopes (nuclides with the same atomic number but different mass numbers), but , , are isobars (nuclides with the same mass number). However, because "isotope" is the older term, it is better known than