Escapement wheels, which because they lacked a balance spring had no natural "beat", so there was not much incentive to improve the escapement. The great leap in accuracy resulting from the invention of the pendulum and balance spring around 1657, which made the timekeeping elements in both watches and clocks harmonic oscillators, focused attention on the errors of the escapement, and more accurate escapements soon superseded the verge. The next two centuries, the "golden age" of mechanical horology, saw the invention of perhaps 300 escapement designs, although only about 10 stood the test of time and were widely used in clocks
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems