Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract Pontefract Pontefract is a historic market town in West Yorkshire, England, near the A1 (or Great North Road) and the M62 motorway. Historically part of the West Riding of Yorkshire, it is one of the five towns in the metropolitan borough of the City of Wakefield and has a population of 28,250, increasing to 30,881 at the 2011 Census. Pontefract's motto is "Post mortem patris pro filio", Latin for "After the death of the father, support the son", a reference to the English Civil War Royalist sympathies. At the end of the 11th century, the modern township of Pontefract consisted