Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Effects of parasitic worms on the immune system infection is more severe because of the parasites. According to Dr. Kamal, the human immune system needs Th1 cells to effectively fight TB. Since the immune system often responds to parasitic worms by inhibiting Th1 cells, parasitic worms generally worsen tuberculosis. In fact, Tuberculosis patients who receive successful parasitic therapy experience major improvement. In 2004, Dr. Sokhna et al. performed a study of Senegalese children. Those infected with blood flukes had significantly higher rates of malaria attacks than those who were not. Furthermore, children with the highest counts of blood flukes also had the most malaria attacks. Based on this