Escapement of most pendulum clocks, and for the development of the grandfather clock, the first anchor clock to be sold commercially, which was invented around 1680 by William Clement, who disputed credit for the escapement with Hooke. The escapement increased the accuracy of pendulum clocks to such a degree that the minute hand was added to the clock face in the late 1600s (before this, clocks had only an hour hand). The anchor consists of an escape wheel with pointed, backward slanted teeth, and an "anchor"-shaped piece pivoted above it which rocks from side to side, linked to the pendulum. The
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a