Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Cyanea glabra Cyanea glabra Cyanea glabra is a rare species of flowering plant in the bellflower family known by the common name smooth cyanea. It is endemic to Maui, where there are twelve plants remaining in the wild. It was federally listed as an endangered species of the United States with nine other Maui Nui endemics in 1999. Like other "Cyanea" it is known as haha in Hawaiian. This Hawaiian lobelioid is a branching shrub that reaches an uncertain height. It grows in wet forests dominated by "Acacia koa" and/or "Metrosideros polymorpha" at . Associated plants include "Cheirodendron trigynum", "Tetraplasandra hawaiensis", "Xylosma