Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Honour of Pontefract Honour of Pontefract The Honour of Pontefract, otherwise known as the Feudal Barony of Pontefract, is a medieval English feudal barony which has existed since 1068 in present-day West Yorkshire. The honour was first granted to Ilbert de Lacy, 1st Baron Pontefract by William the Conqueror following his participation in the Harrying of the North. His son Robert supported Robert Curthose and was banished, the Honour being transferred to a Henry Traverse. Traverse himself was murdered three days later, and the barony changed hands again to Hugh de la Val. The de Lacy family were restored as Barons during the