Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Behavioral immune system Behavioral immune system The behavioral immune system is a phrase coined by the psychological scientist Mark Schaller to refer to a suite of psychological mechanisms that allow individual organisms to detect the potential presence of disease-causing parasites in their immediate environment, and to engage in behaviors that prevent contact with those objects and individuals. These mechanisms include sensory processes through which cues connoting the presence of parasitic infections are perceived (e.g., the smell of a foul odor, the sight of pox or pustules), as well as stimulus–response systems through which these sensory cues trigger a cascade of aversive affective, cognitive,