Verge escapement verge escapement mechanism was applied to tower clocks, creating the first mechanical clock. In spite of the fact that these clocks were celebrated objects of civic pride which were written about at the time, it may never be known when the new escapement was first used. This is because it has proven difficult to distinguish from the meager written documentation which of these early tower clocks were mechanical, and which were water clocks; the same Latin word, "horologe", was used for both. None of the original mechanisms have survived unaltered. Sources differ on which was the first clock 'known' to
Controlled internal drug release Controlled internal drug release Controlled internal drug release (CIDR) devices are used in livestock for the synchronization of estrus. They are T-shaped devices with a silicone-coated nylon core. The silicone coating is impregnated with progesterone. CIDRs are inserted intra-vaginally using a specialized applicator. The flexible wings collapse for facilitated insertion and expand once placed appropriately within the vagina. The expansion of the wings retains its position; CIDRs have very high retention rates that may exceed 97%. A thin nylon tail remains exteriorized and is used for removal. Once inserted, CIDRs provide slow-release administration of progesterone, which artificially extends the luteal