Anchor escapement it he showed that the wide pendulum swings of verge clocks caused them to be inaccurate, because the period of oscillation of the pendulum was not isochronous but varied to a small degree due to circular error with changes in the amplitude of the pendulum's swing, which occurred with unavoidable changes in drive force. The realization that only small pendulum swings were nearly isochronous motivated clockmakers to design small swing escapements. The chief advantage of the anchor was that by locating the pallets farther from the pivot, the swing of the pendulum was reduced from around 100° in verge clocks
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems