Verge escapement in mechanical clocks. In the sixteenth century alternative escapements started to appear, but the verge remained the most used escapement for 350 years until mid-17th century advances in mechanics, resulted in the adoption of the pendulum, and later the anchor escapement. Since clocks were valuable, after the invention of the pendulum many verge clocks were rebuilt to use this more accurate timekeeping technology, so very few of the early "verge and foliot" clocks have survived unaltered to the present day. How accurate the first verge and foliot clocks were is debatable, with estimates of one to two hours error per
Controlled internal drug release Controlled internal drug release Controlled internal drug release (CIDR) devices are used in livestock for the synchronization of estrus. They are T-shaped devices with a silicone-coated nylon core. The silicone coating is impregnated with progesterone. CIDRs are inserted intra-vaginally using a specialized applicator. The flexible wings collapse for facilitated insertion and expand once placed appropriately within the vagina. The expansion of the wings retains its position; CIDRs have very high retention rates that may exceed 97%. A thin nylon tail remains exteriorized and is used for removal. Once inserted, CIDRs provide slow-release administration of progesterone, which artificially extends the luteal