Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract the arrival of the Normans in 1068 is known as the Anglo-Scandinavian age. The modern township of Pontefract consisted of two Anglo-Scandinavian settlements, known as Tanshelf and Kirkby. In Yorkshire, place-name locations often contain the distinctive Danish '-by' i.e. Kirkby. And even today, the major streets in Pontefract are designated by the Danish word 'gate' e.g. Bailygate. The Anglo-Scandinavian township of Tanshelf recorded variously as "Tateshale", "Tateshalla", "Tateshalle" or "Tatessella" in the 1086 "Domesday Book" existed in the region that is today occupied by the town of Pontefract. The Anglo-Saxon Chronicle makes its first reference to Tanshelf in the year