Period 2 element two make up all natural occurrence of lithium on Earth, although further isotopes have been synthesized. In ionic compounds, lithium loses an electron to become positively charged, forming the cation Li. Lithium is the first alkali metal in the periodic table, and the first metal of any kind in the periodic table. At standard temperature and pressure, lithium is a soft, silver-white, highly reactive metal. With a density of 0.564 g·cm, lithium is the lightest metal and the least dense solid element. Lithium is one of the few elements synthesized in the Big Bang, making it a primordial element. Lithium
Dose-dense chemotherapy allow rapid growth for a short time before the next treatment. By decreasing the dose and increasing the frequency, the fast growth can be prevented, allowing for faster and more effective cure rate. Although the dose is reduced in each treatment, the total quantity of chemotherapy may or may not be increased over the duration of the typical treatment time. For example, in standard treatment of ovarian cancer, paclitaxel is given at 175 mg/m body surface every three weeks. In dose dense therapy paclitaxel is given at 50–80 mg/m every week (150–240 mg/m in 3-weeks). Dose-dense chemotherapy Dose-dense chemotherapy is