Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Cat-scratch disease Warthin-Starry silver stain was used to discover a Gram-negative bacillus which was named "Afipia felis" in 1991 after it was successfully cultured and isolated. The causative organism of CSD was originally believed to be "Afipia felis", but this was disproved by immunological studies in the 1990s demonstrating that cat-scratch fever patients developed antibodies to two other organisms, "B. henselae" (originally known as "Rochalimea henselae" before the genera "Bartonella" and "Rochalimea" were combined) and "B. clarridgeiae", which is a rod-shaped Gram-negative bacterium. Cat-scratch disease Cat-scratch disease (CSD) is an infectious disease that results from a scratch or bite of a cat.