Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Behavioral immune system prototypical human being. The disease–avoidant processes that characterize the behavioral immune system have been shown to contribute to prejudices against obese individuals, elderly individuals, and people with physical disfigurements or disabilities. In addition, the behavioral immune system appears to contribute to xenophobia and ethnocentrism. One implication is that these prejudices tend to be exaggerated under conditions in which people feel especially vulnerable to the potential transmission of infectious diseases. Additional lines of research on the behavioral immune system have shown that people engage in more reticent and conservative forms of behavior under conditions in which they feel more vulnerable to