Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract line to Goole by this route. Railways in the area opened as follows: Before the 1923 Grouping the lines over which the service operates were owned by: Trains using the Pontefract line from Leeds use the same route as the Hallam line to "Methley Junction": The Wakefield service joins the Leeds service at Pontefract; the station served for this section are: Pontefract line The Pontefract line is one of the rail services in the West Yorkshire Metro area of northern England. The service is operated by Northern, and links Wakefield and Leeds with Goole via Pontefract. The Metro timetable for the