Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract Friary Pontefract Friary St Richard's Friary, also known as Pontefract Friary, was a Dominican friary in Pontefract, West Yorkshire, England. It was located near today's Pontefract General Infirmary, on the eastern edge of Friarwood Valley Gardens. It was founded in 1256 on land donated by Edmund de Lacy in honour of Richard de Wych, Bishop of Chichester on 6 acres of land at the edge of the town. The town centre was by then already too densely built to offer a sufficiently big building site. Since the Dominicans, also known as Black Friars, were a mendicant order without property, land, building