Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Immune Attack Immune Attack Immune Attack is an educational video game created by the Federation of American Scientists and Escape Hatch Entertainment. Early development of the game was done by Brown University, in collaboration with the University of Southern California, under a grant from the National Science Foundation. The game is designed to teach immunology to high school students, although later versions will cater to college aged students as well. The game was officially released in May 2008, and is freely available for download. The protagonist of Immune Attack is a teenaged prodigy in the near-future with a unique immunodeficiency in which