Anchor escapement anchor in his invention of the longcase or grandfather clock around 1680. When Clement's clock appeared Hooke claimed the invention of the escapement, saying that he had shown a clock with the same escapement to the Royal Society soon after the great fire of 1666. The earliest known anchor clock is Wadham College Clock, a tower clock built at Wadham College, Oxford, in 1670, probably by clockmaker Joseph Knibb. The anchor became the standard escapement used in almost all pendulum clocks. A variation without recoil called the deadbeat escapement was invented by Richard Towneley around 1675 and introduced by British
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a