Lever escapement escapement was invented by British clockmaker Thomas Mudge around 1755, and improved by Abraham-Louis Breguet (1787), Peter Litherland (1791), Edward Massey (1800), and its modern ("table roller") form was developed by George Savage in the early 1800s. Since about 1900 virtually every mechanical watch, alarm clock and other portable timepiece has used the lever escapement. The advantages of the lever are, first, that it is a "detached" escapement, it allows the balance wheel to swing completely free of the escapement during most of its oscillation, except when giving it a short impulse, improving timekeeping accuracy. Second, due to "locking" and
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a