Mass in special relativity what causes these particles to be termed "massless." However, even massless particles have a relativistic mass, which varies with their observed energy in various frames of reference, The invariant mass is the ratio of four-momentum (the four-dimensional generalization of classical momentum) to four-velocity: and is also the ratio of four-acceleration to four-force when the rest mass is constant. The four-dimensional form of Newton's second law is: The relativistic expressions for "E" and "p" obey the relativistic energy–momentum relation: where the m is the rest mass, or the invariant mass for systems, and "E" is the total energy. The equation is
N,N-Dimethyltryptamine (step 1). The resulting decarboxylated tryptophan analog is tryptamine. Tryptamine then undergoes a transmethylation (step 2): the enzyme indolethylamine-N-methyltransferase (INMT) catalyzes the transfer of a methyl group from cofactor S-adenosyl-methionine (SAM), via nucleophilic attack, to tryptamine. This reaction transforms SAM into S-adenosylhomocysteine (SAH), and gives the intermediate product "N"-methyltryptamine (NMT). NMT is in turn transmethylated by the same process (step 3) to form the end product "N","N"-dimethyltryptamine. Tryptamine transmethylation is regulated by two products of the reaction: SAH, and DMT were shown "ex vivo" to be among the most potent inhibitors of rabbit INMT activity. This transmethylation mechanism has been