Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Avian immune system The cause is believed to be high exposure to UV rays. Additionally, a cancer of the connective tissue, known as fibrosarcoma, is often seen in the leg or wing. This occurs in many parrot species, cockatiels, macaws and budgerigars. Treatment options include amputation and surgery. Avian immune system The avian immune system refers to the system of biological structures and cellular processes that protects birds from disease. The avian immune system resembles that of mammals since both evolved from a common reptilian ancestor and have inherited many commonalities. They have also developed a number of different strategies that are unique