Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Wolf attack animal may break off the attack or be convinced to look elsewhere for its next meal. In contrast, during "determined" predatory attacks, the victims may be repeatedly bitten on the head and face and dragged off and consumed, sometimes as far away as 1-2.5 km from the attack site, unless the wolf or wolves are driven off. Experts in India use the term "child lifting" to describe predatory attacks in which the animal silently enters a hut while everyone is sleeping, picks up a child, often with a silencing bite to the mouth and nose, and carries a child off