Pulmonary edema The development of pulmonary edema may be associated with symptoms and signs of "fluid overload"; this is a non-specific term to describe the manifestations of right ventricular failure on the rest of the body and includes peripheral edema (swelling of the legs, in general, of the "pitting" variety, wherein the skin is slow to return to normal when pressed upon), raised jugular venous pressure and hepatomegaly, where the liver is enlarged and may be tender or even pulsatile. Other signs include end-inspiratory crackles (sounds heard at the end of a deep breath) on auscultation and the presence of a third
Tissue residue the exposure media. In general, tissue residue approaches are used for chemicals that bioaccumulate or for bioaccumulative chemicals. The majority of these substances are organic compounds that are not easily metabolized by organisms and have long environmental persistence. Examples of these chemicals include: polychlorinated dibenzodioxins, furans, biphenyls, DDT and its metabolites, and dieldrin. The use of tissue residues in assessing toxicity and bioaccumulation may also be referred to as the tissue residue-effects approach (TRA), critical body residue (CBR) or tissue residue-based toxicity tests. Historically, aquatic toxicology toxicity tests have focused on water-based approaches where concentration of a toxicant is determined