Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Behavioral immune system disease transmission. For instance, when the potential threat of disease is made salient, people tend to be less extraverted or sociable. Evidence suggests that the behavioral immune system also incorporates mechanisms designed to search out and process (heuristic) signs of disease at the level of basic visual attention. The behavioral immune system also has consequences at a cultural level of analysis. Under ecological circumstances in which diseases are more prevalent, people also tend to display more reticent and socially restricted forms of behavior, and human cultures are defined by more conservative norms and value systems. Some research suggests that the