Edema Edema Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain. Clinically, edema manifests as swelling. The amount of interstitial fluid is determined by the balance of fluid homeostasis and the increased secretion of fluid into the interstitium. The word is from Greek "oídēma" meaning "swelling". The condition is also known (mostly archaic) as dropsy. Cutaneous edema is referred to as "pitting" when, after pressure is applied to a small area, the indentation persists after the release of the
Cerebral edema such as ischemic stroke, cancer, or brain inflammation due to meningitis or encephalitis. Vasogenic edema caused by amyloid-modifying treatments, such as monoclonal antibodies, is known as ARIA-E (amyloid-related imaging abnormalities edema). The blood–brain barrier (BBB) or the blood–cerebrospinal fluid (CSF) barrier may break down, allowing fluid to accumulate in the brain's extracellular space. One manifestation of this is P.R.E.S., or Posterior Reversible Encephalopathy Syndrome. Altered metabolism may cause brain cells to retain water, and dilution of the blood plasma may cause excess water to move into brain cells. Fast travel to high altitude without proper acclimatization can cause high-altitude cerebral