Escapement of clocks, points to the late 13th century as the most likely date for the development of the modern clock escapement. Astronomer Robertus Anglicus wrote in 1271 that clockmakers were trying to invent an escapement, but hadn't been successful yet. On the other hand, most sources agree that mechanical escapement clocks existed by 1300. Actually, the earliest description of an escapement, in Richard of Wallingford's 1327 manuscript "Tractatus Horologii Astronomici" on the clock he built at the Abbey of St. Albans, was not a verge, but a variation called a "strob" escapement. It consisted of a pair of escape wheels
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a