Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract Hermitage Pontefract Hermitage Pontefract Hermitage is a medieval hermitage situated below the old Southgate entrance to the General Infirmary in Pontefract, West Yorkshire, England. It is a grade I listed structure. The retreat consists of two chambers carved out of sandstone, side by side but on different levels. From the lower chamber a 63 step spiral staircase descends to a well. The later upper chamber, known as the Oratory, measures by with a domed ceiling up to 8 feet high. The Oratory contains an altar, a fireplace, a bench and low stool and a bed shelf. The entrance to the hermitage