Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Wolf attack in newspapers throughout the entire United States. Following the Icy Bay incident, biologist Mark E. McNay compiled a record of wolf-human encounters in Canada and Alaska from 1915-2001. Of the 80 described encounters, 39 involved aggressive behavior from apparently healthy wolves and 12 from animals confirmed to be rabid. The first fatal attack in the 21st century occurred on November 8, 2005, when a young man was killed by wolves that had been habituated to people in Points North Landing, Saskatchewan, Canada while on March 8, 2010, a young woman was killed while jogging near Chignik, Alaska. Wolf attack Although