Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Behavioral immune system and behavioral reactions (e.g., arousal of disgust, automatic activation of cognitions that connote the threat of disease, behavioral avoidance). The existence of a behavioral immune system has been documented across many animal species, including humans. It is theorized that the mechanisms that comprise the behavioral immune system evolved as a crude first line of defense against disease-causing pathogens. Within the psychological sciences, there is extensive research linking the behavioral immune system to a variety of prejudices—including prejudices against people who aren't actually diseased but are simply characterized by some sort of visual characteristics that deviate from those of a subjectively