Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Chelone glabra glabra" is a popular browse plant for deer. It is also a foodplant for the sawflies "Macrophya nigra" and "Tenthredo grandis" (Hymenoptera: Tenthredinidae), and a flea beetle in the genus Dibolia (Coleoptera: Chrysomelidae) has also been shown to feed on it. It has been used as a method of birth control by Abenaki people. 11. Allan D. Nelson; Wayne J. Elisens (1999). "Polyploid evolution and biogeography in Chelone (Scrophulariaceae): morphological and isozyme evidence". "American Journal of Botany". Botanical Society of America. 86(10): 1487–1501. doi:10.2307/2656929. JSTOR 2656929. PMID 10523288. Chelone glabra Chelone glabra (white turtlehead) is an herbaceous species of plant