Verge escapement in mechanical clocks. In the sixteenth century alternative escapements started to appear, but the verge remained the most used escapement for 350 years until mid-17th century advances in mechanics, resulted in the adoption of the pendulum, and later the anchor escapement. Since clocks were valuable, after the invention of the pendulum many verge clocks were rebuilt to use this more accurate timekeeping technology, so very few of the early "verge and foliot" clocks have survived unaltered to the present day. How accurate the first verge and foliot clocks were is debatable, with estimates of one to two hours error per
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a