Isotope …, "m" are the atomic masses of each individual isotope, and "x", …, "x" are the relative abundances of these isotopes. Several applications exist that capitalize on properties of the various isotopes of a given element. Isotope separation is a significant technological challenge, particularly with heavy elements such as uranium or plutonium. Lighter elements such as lithium, carbon, nitrogen, and oxygen are commonly separated by gas diffusion of their compounds such as CO and NO. The separation of hydrogen and deuterium is unusual because it is based on chemical rather than physical properties, for example in the Girdler sulfide process.
Relative atomic mass weights, which are ubiquitous in chemical laboratories and which are revised biennially by the IUPAC's Commission on Isotopic Abundances and Atomic Weights (CIAAW). Older (pre-1961) historical relative scales based on the atomic mass unit (symbol: "a.m.u." or "amu") used either the oxygen-16 relative isotopic mass or else the oxygen relative atomic mass (i.e., atomic weight) for reference. See the article on the history of the modern unified atomic mass unit for the resolution of these problems. The IUPAC commission CIAAW maintains an expectation-interval value for relative atomic mass (or atomic weight) on Earth named standard atomic weight. Standard atomic weight