Keratin 6C "chromosome" 12q. Keratin 6A and keratin 6B are encoded by the neighbouring genes, which are identical in intron-exon organization to "KRT6C" and are more than 99% identical in their DNA coding sequences. Mutations in K6C have been identified as being able to cause diffuse and focal palmoplantar keratodermas. This has been identified as a form of Pachyonychia congenita. Keratin 6C Keratin 6C (protein name K6C; gene name "KRT6C"), is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. This gene
Myosin head Myosin head Muscle contraction is caused by the sliding action of thick filaments over thin filaments of the myofibril. Myosin is a major component of thick filaments and most myosin molecules are composed of a head, neck, and tail domain; the myosin head binds to thin filamentous actin, and uses ATP hydrolysis to generate force and "walk" along the thin filament. Myosin exists as a hexamer of two heavy chains, two alkali light chains, and two regulatory light chains. The heavy chain can be subdivided into the globular head at the N-terminal and the coiled-coil rod-like tail at the C-terminal,