Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Wolf attack pro-wolf lobby aiming to change public attitudes towards wolves, with the phrase “there has never been a documented case of a healthy wild wolf attacking a human in North America” (or variations thereof) becoming a slogan for people seeking to create a more positive image for the wolf. Although several non-fatal attacks had been reported since 1985, it was not until April 26, 2000 when a 6-year-old boy survived an attack by a wolf in Icy Bay, Alaska that the assumption that healthy wild wolves were harmless became seriously challenged. The event was considered so unusual that it was reported