Escapement eventually became the escapement of choice for turret clocks, because their wheel trains are subjected to large variations in drive force caused by the large exterior hands, with their varying wind, snow, and ice loads. Since in a gravity escapement the drive force from the wheel train does not itself impel the pendulum but merely resets the weights that provide the impulse, the escapement is not affected by variations in drive force. The 'Double Three-legged Gravity Escapement' shown here is a form of escapement first devised by a barrister named Bloxam and later improved by Lord Grimthorpe. It is the
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems