Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
International Union for the Protection of New Varieties of Plants is known to consider open and un-restricted access to the genetic resources of protected plant varieties to be important to the continued development of new varieties. This opinion is indicated in the "breeders' exemption" clause of the Convention, as described above, and was reinforced in October 2005 in a reply to a notification from the Convention on Biological Diversity. In April 2003, the Convention on Biological Diversity asked the UPOV for comment on the use of Genetic Use Restriction Technologies (also known pejoratively as 'terminator genes') as they relate to the promotion of intellectual property rights. In the summary of