Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract of Pontefract was known by the Anglo-Scandinavian name of Kirkby. After the Norman conquest in 1066 almost all of Yorkshire came under the ownership of followers of William the Conqueror, one of whom was Ilbert de Lacy who became the owner of Tateshale (Tanshelf) where he began to build a castle. Pontefract Castle began as a wooden motte and bailey castle, built before 1086 and later rebuilt in stone. The de Lacys lived in the castle for more than two centuries and were holders of the castle and the Honour of Pontefract from 1067 until the death of Alice de