Escapement of clocks, points to the late 13th century as the most likely date for the development of the modern clock escapement. Astronomer Robertus Anglicus wrote in 1271 that clockmakers were trying to invent an escapement, but hadn't been successful yet. On the other hand, most sources agree that mechanical escapement clocks existed by 1300. Actually, the earliest description of an escapement, in Richard of Wallingford's 1327 manuscript "Tractatus Horologii Astronomici" on the clock he built at the Abbey of St. Albans, was not a verge, but a variation called a "strob" escapement. It consisted of a pair of escape wheels
Controlled internal drug release Controlled internal drug release Controlled internal drug release (CIDR) devices are used in livestock for the synchronization of estrus. They are T-shaped devices with a silicone-coated nylon core. The silicone coating is impregnated with progesterone. CIDRs are inserted intra-vaginally using a specialized applicator. The flexible wings collapse for facilitated insertion and expand once placed appropriately within the vagina. The expansion of the wings retains its position; CIDRs have very high retention rates that may exceed 97%. A thin nylon tail remains exteriorized and is used for removal. Once inserted, CIDRs provide slow-release administration of progesterone, which artificially extends the luteal