Verge escapement verge escapement mechanism was applied to tower clocks, creating the first mechanical clock. In spite of the fact that these clocks were celebrated objects of civic pride which were written about at the time, it may never be known when the new escapement was first used. This is because it has proven difficult to distinguish from the meager written documentation which of these early tower clocks were mechanical, and which were water clocks; the same Latin word, "horologe", was used for both. None of the original mechanisms have survived unaltered. Sources differ on which was the first clock 'known' to
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a