Anchor escapement to only 4°-6°. In addition to the improved accuracy due to isochronism, this allowed clocks to use longer pendulums, which had a slower 'beat'. Lower air drag meant they needed less power to keep swinging, and caused less wear on the clock's movement. The anchor also allowed the use of a heavier pendulum bob for a given drive force, making the pendulum more independent of the escapement (higher Q), and thus more accurate. These long pendulums required long narrow clock cases. Around 1680 British clockmaker William Clement began selling the first commercial clocks to use the anchor escapement, tall freestanding
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems