Riefler escapement Riefler escapement The Riefler escapement is a mechanical escapement for precision pendulum clocks invented and patented by German instrument maker Sigmund Riefler in 1889. It was used in the astronomical regulator clocks made by his German firm Clemens Riefler from 1890 to 1965, which were perhaps the most accurate all-mechanical pendulum clocks made. An escapement is the mechanism in a mechanical clock that gives the pendulum precise impulses to keep it swinging, and allows the gear train to advance a set amount with each pendulum swing. The Riefler escapement was an improvement of the deadbeat escapement, the standard used in
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems