Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Tolman Sweet prairie region of the Middle West, Tolman Sweet has gained the reputation of being one of the hardiest of the old New England varieties. For this reason it is often selected as a stock upon which to top-graft less hardy kinds. The tree comes into bearing at a moderately early age, and, generally speaking, is a reliable cropper, yielding from moderate to heavy crops biennially or sometimes almost annually." The same source was unable to locate the origin of the variety, perhaps coming from Massachusetts. It was among the most popular sweet varieties in orchards in New York State at