Anchor escapement clocks. During the 19th century the deadbeat form gradually took over in most quality clocks, but the anchor form is still used in a few pendulum clocks today. The anchor escapement is reliable and tolerant of large geometrical errors in its construction, but its operation is similar to the old verge escapement, and retains two of the major disadvantages of the verge: The above two disadvantages were removed with the invention of an improved version of the anchor escapement: the deadbeat or Graham escapement. This is often erroneously credited to English clockmaker George Graham who introduced it around 1715 in
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems