Glycyrrhiza lepidota in the spring which ripen in the fall to clusters of burs which contain pods of small bean-like seeds. It can be used as a pioneer species to revegetate bare or disturbed ground and is often the first species to invade a receding alkali flat. There is a market for American licorice root both for medicinal uses and flavoring; also the sweetening of tobacco products. Glycyrrhiza lepidota Glycyrrhiza lepidota (American licorice) is a species of "Glycyrrhiza" (a genus in the pea/bean family, Fabaceae) native to most of North America, from central Canada south through the United States to California, Texas
Glycyrrhizin glycyrrhizin is first hydrolysed to 18β-glycyrrhetinic acid (enoxolone) by intestinal bacteria. After complete absorption from the gut, 18β-glycyrrhetinic acid is metabolised to 3β-monoglucuronyl-18β-glycyrrhetinic acid in the liver. This metabolite then circulates in the bloodstream. Consequently, its oral bioavailability is poor. The main part is eliminated by bile and only a minor part (0.31–0.67%) by urine. After oral ingestion of 600 mg of glycyrrhizin the metabolite appeared in urine after 1.5 to 14 hours. Maximal concentrations (0.49 to 2.69 mg/l) were achieved after 1.5 to 39 hours and metabolite can be detected in the urine after 2 to 4 days. Glycyrrhizin