Glycyrrhizin an increase in blood pressure, may cause irregular heart rhythm, and adverse interactions with prescription medicines. The effects on body fluids are related to the inhibition of cortisol metabolism within the kidney, subsequent stimulation of the mineralocorticoid receptors, and decrease in blood levels of renin, potassium, and aldosterone, which collectively lead to increases in blood pressure. Depending on amount and frequency of ingesting black licorice, other side effects may include: Glycyrrhizin is under laboratory and preliminary clinical research for its possible activity against common viruses, such as hepatitis C. In vitro, glycyrrhizin inhibits the enzyme 11β-hydroxysteroid dehydrogenase. After oral ingestion,
Pontefract line Pontefract line The Pontefract line is one of the rail services in the West Yorkshire Metro area of northern England. The service is operated by Northern, and links Wakefield and Leeds with Goole via Pontefract. The Metro timetable for the line also includes services operated as the Dearne Valley line between York and Sheffield via Pontefract. The line, which passes through the former mining areas to the east of Wakefield and Castleford, has the greatest number of stations opened by the West Yorkshire Metro. MetroCards are available on the route as far as Knottingley: a limited service of trains continues