Mixed connective tissue disease connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. MCTD combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis) and is thus considered an overlap syndrome. MCTD commonly causes: It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. The prognosis of mixed connective tissue disease is in one third of cases worse than that of systemic lupus erythematosus (SLE). In spite
Wolf attack in newspapers throughout the entire United States. Following the Icy Bay incident, biologist Mark E. McNay compiled a record of wolf-human encounters in Canada and Alaska from 1915-2001. Of the 80 described encounters, 39 involved aggressive behavior from apparently healthy wolves and 12 from animals confirmed to be rabid. The first fatal attack in the 21st century occurred on November 8, 2005, when a young man was killed by wolves that had been habituated to people in Points North Landing, Saskatchewan, Canada while on March 8, 2010, a young woman was killed while jogging near Chignik, Alaska. Wolf attack Although