Escapement of the slave pendulum for one swing. The slave pendulum was adjusted to run slightly slow, such that on approximately every other synchronization pulse the spring would be caught by the armature. This form of clock became a standard for use in observatories (roughly 100 such clocks were manufactured), and was the first clock capable of detecting small variations in the speed of Earth's rotation. Escapement An escapement is a device in mechanical watches and clocks that transfers energy to the timekeeping element (the "impulse action") and allows the number of its oscillations to be counted (the "locking action"). The
Osmotic-controlled release oral delivery system Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems