Myosin with two FERM domains in the tail region. It has an extended lever arm consisting of five calmodulin binding IQ motifs followed by a single alpha helix (SAH). Myosin VII is required for phagocytosis in "Dictyostelium discoideum", spermatogenesis in "C. elegans" and stereocilia formation in mice and zebrafish. Myosin VIII is a plant-specific myosin linked to cell division; specifically, it is involved in regulating the flow of cytoplasm between cells and in the localization of vesicles to the phragmoplast. Myosin IX is a group of single-headed motor proteins. It was first shown to be minus-end directed, but a later study
Keratin 5 heterodimers are formed between specific pairs of type I (acidic) and type II (basic) keratin. K5, a type II keratin, pairs with the type I keratin K14. The coiled-coil dimers undergo stepwise assembly and combine in an antiparallel manner, forming end-to-end interactions with other coiled-coils to form large 10 nm intermediate filaments. Keratin 5 (and K14) are expressed primarily in basal keratinocytes in the epidermis, specifically in the stratified epithelium lining the skin and digestive tract. Keratin intermediate filaments make up the cytoskeletal scaffold within epithelial cells, which contributes to the cell architecture and provides the cells with the ability