Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Evolution of Infectious Disease The way a host lives contributes heavily to how their body will react to pathogens. If an organism lives a moderately healthy lifestyle, including their diet, physical activity, and has a decreased amount of stress to deal with, their chances of fighting off infectious diseases increases. Host resistance pivots around how well a host’s immune system can fight off a disease and rid their body of the pathogens. Although a healthy lifestyle can help a host, infectious diseases seem to evolve so quickly that a new generation of a disease may have emerged before scientists have the chance to make