Anchor escapement teeth, which made the escape wheel rotate once per minute so the second hand could be attached to its shaft. In a 30 tooth escape wheel the pallets span about 7½ teeth. The impulse angle of the pallets, which determined the swing of the pendulum, was 3°-4°. The anchor was the second widely used escapement in Europe, replacing the 400-year-old verge escapement in pendulum clocks. The pendulums in verge escapement clocks had very wide swings of 80° to 100°. In 1673, seventeen years after he invented the pendulum clock, Christiaan Huygens published his mathematical analysis of pendulums, "Horologium Oscillatorium". In
Osmotic-controlled release oral delivery system separate drug layers with different concentrations of methylphenidate in addition to the (now quite robust) push layer. OROS medications include: Osmotic-controlled release oral delivery system The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic pressure is used to push the active drug through the opening(s) in the tablet. OROS is a