Cerebral edema early stroke or hypoxia, cardiac arrest, and pseudotumor cerebri. During an ischemic stroke, a lack of oxygen and glucose leads to a breakdown of the sodium-calcium pumps on brain cell membranes, which in turn results in a massive buildup of sodium and calcium intracellularly. This causes a rapid uptake of water and subsequent swelling of the cells. It is this swelling of the individual cells of the brain that is seen as the main distinguishing characteristic of cytotoxic edema, as opposed to vasogenic edema, wherein the influx of fluid is typically seen in the interstitial space rather than within the
Heat edema of heat edema. Heat edema Heat edema is a cutaneous condition characterized by dependent edema from vasodilatory pooling. Heat causes the blood vessels to expand (dilate), so body fluid moves into the hands or legs by gravity. The balance of salt in the body is also a risk factor for heat edema. If salt loss is less than normal, the increased salt level draws fluid into the hands and legs. Older adults have an increased risk of heat edema, especially if they have other medical conditions that affect their circulation. People visiting hot climates from colder climates may also have