Isotope fractionation become enriched in the liquid phase while the lighter isotopes (O and H) tend toward the vapor phase. Isotope fractionation Isotope fractionation describes processes that affect the relative abundance of isotopes, often used in isotope geochemistry. Normally, the focus is on stable isotopes of the same element. Isotopic fractionation in the natural environment can be measured by isotope analysis, using isotope-ratio mass spectrometry, to separate different element isotopes on the basis of their mass-to-charge ratio, an important tool to understand natural systems. For example, in biochemistry processes cause a fluctuation in the amount of isotopes of carbon ratios incorporated into
Atomic mass unit of exactly 16 amu in physics. The divergence of these values could result in errors in computations, and was unwieldy. The chemistry amu, based on the relative atomic mass (atomic weight) of natural oxygen (including the heavy naturally-occurring isotopes O and O), was about as massive as the physics amu, based on pure isotopic O. For these and other reasons, the reference standard for both physics and chemistry was changed to carbon-12 in 1961. The choice of carbon-12 was made to minimise further divergence with prior literature. The new and current unit was referred to as the "unified atomic mass