Immune tolerance the resulting effect is similar. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.). Deficits in central or peripheral tolerance also cause autoimmune disease, resulting in syndromes such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, autoimmune polyendocrine syndrome type 1 (APS-1), and immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and potentially contribute to asthma, allergy, and inflammatory bowel disease. And immune tolerance in pregnancy is what allows
Effects of parasitic worms on the immune system to Dr. Rook. This theory and the theory that certain parasitic worms pacify the immune response are similar in that both theories attribute the recent rise of autoimmune diseases to the decreased levels of pathogens in developed countries. However, the Hygiene Hypothesis claims that the absence of pathogenic organisms in general has led to this. In contrast, the parasitic worm theory only analyzes helminths, and specifically ones found to have a regulating effect. Type diabetes (T1D) is an autoimmune disease in which the immune system destroys the body's pancreatic beta cells. In an experiment with mice, infection with parasitic worms