Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Mexican Americans an army to defend themselves from invading American forces after the Mexican army retreated from Alta California to defend other parts of Mexico. The Californios defeated an American force in Los Angeles on September 30, 1846. In turn, they were defeated after the Americans reinforced their forces in what is now southern California. Tens of thousands of miners and associated people arrived during the California Gold Rush, and their activities in some areas meant the end of the Californios' ranching lifestyle. Many of the English-speaking 49ers turned from mining to farming and moved, often illegally, onto land granted to Californios