Lewis acids and bases ionic bonding. Classically, the term "Lewis acid" is restricted to trigonal planar species with an empty p orbital, such as BR where R can be an organic substituent or a halide. For the purposes of discussion, even complex compounds such as EtAlCl and AlCl are treated as trigonal planar Lewis acids. Metal ions such as Na, Mg, and Ce, which are invariably complexed with additional ligands, are often sources of coordinatively unsaturated derivatives that form Lewis adducts upon reaction with a Lewis base[citation needed]. Other reactions might simply be referred to as "acid-catalyzed" reactions. Some compounds, such as HO, are
Substance P nitric oxide release. Substance P is involved in the axon reflex-mediated vasodilatation to local heating and wheal and flare reaction. It has been shown that vasodilatation to substance P is dependent on the NK1 receptor located on the endothelium. In contrast to other neuropeptides studied in human skin, substance P-induced vasodilatation has been found to decline during continuous infusion. This possibly suggests an internalization of neurokinin-1 (NK1). As is typical with many vasodilators, it also has bronchoconstrictive properties, administered through the non-adrenergic, non-cholinergic nervous system (branch of the vagal system). SP initiates expression of almost all known immunological chemical messengers