Dysphoric milk ejection reflex sense of depression and this feeling can range from mild homesickness or wistfulness to more intense feelings of hopelessness and self-loathing. Similarly, anxiety may range from restlessness to more intense panic and dread. Anger, the least likely of the three, may range from tension and agitation to more intense feelings of hostility and aggression. The mechanism is not clear. In a mother with D-MER, dopamine may fall inappropriately with milk release, causing the negative feelings. Among the hormones involved in milk production and release are oxytocin, prolactin, and dopamine. Oxytocin, released in pulsatile "spikes" from the posterior pituitary in response
Corticotropin-releasing hormone receptor 1 II and urocortin III. Variations in the "CRHR1" gene is associated with enhanced response to inhaled corticosteroid therapy in asthma. CRF1 triggers cells to release hormones that are linked to stress and anxiety [original reference missing].Hence CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety. Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn. Corticotropin-releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone and Urocortin. Corticotropin-releasing hormone receptor 1 Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF, with the latter (CRF) now being the IUPHAR-recommended