Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Genocide of indigenous peoples toll in subsequent centuries. As detailed in "American Philosophy: From Wounded Knee to the Present", "It is also apparent that the shared history of the hemisphere is one framed by the dual tragedies of genocide and slavery, both of which are part of the legacy of the European invasions of the past 500 years. Indigenous people north and south were displaced, died of disease, and were killed by Europeans through slavery, rape, and war. In 1491, about 145 million people lived in the western hemisphere. By 1691, the population of indigenous Americans had declined by 90-95 percent, or by around