Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Indigenous peoples of Mexico and Tzotzil Maya; Hidalgo with 36.21%, the majority being Otomi; Puebla with 35.28%, and Guerrero with 33.92%, mostly Nahua people and the states of San Luis Potosí and Veracruz both home to a population of 19% indigenous people, mostly from the Totonac, Nahua and Teenek (Huastec) groups. The majority of the indigenous population is concentrated in the central and southern states. According to the CDI, the states with the greatest percentage of indigenous population as of 2015 are: In 2011 a large scale mitochondrial sequencing in Mexican Americans revealed 85 to 90% of maternal mtDNA lineages are of Native American