Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Indigenous religious beliefs of the Tagalog people describe all these spirits together, Spanish missionaries eventually decided to call them "anito," since they were the subject of the Tagalog's act of "pag-aanito" (worship). According to Scott, a careful search of sources from the 1500s reveals that:""there was no single word in Tagalog for the other deities to whom Bathala was superior: when necessary, Spanish lexicographers referred to them all as anito."" According to Scott, accounts and early dictionaries describe them as intermediaries ("Bathala's agents"), and the dictionaries used the word "abogado" (advocate) when defining their realms. These sources also show, however, that in practice, they were addressed directly: