Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous peoples of Mexico Indigenous peoples of Mexico Indigenous peoples of Mexico (), Native Mexicans (), or Mexican Native Americans (), are those who are part of communities that trace their roots back to populations and communities that existed in what is now Mexico prior to the arrival of Europeans. According to the National Commission for the Development of Indigenous Peoples ("Comisión Nacional para el Desarrollo de los Pueblos Indígenas", or CDI in Spanish) and the INEGI (official census institute), in 2015, 25,694,928 people in Mexico self-identify as being indigenous of many different ethnic groups, which constitute 21.5% of Mexico's population. In the second