Refractory period (sex) after orgasm in which further sexual stimulation does not produce excitement. While the refractory period varies widely among individuals, ranging from minutes to days, most men cannot achieve or maintain an erection during this time, and many perceive a psychological feeling of satisfaction and are temporarily uninterested in further sexual activity; the penis may be hypersensitive and further sexual stimulation may feel painful during this time frame. An increased infusion of the hormone oxytocin during ejaculation is believed to be chiefly responsible for the male refractory period, and the amount by which oxytocin is increased may affect the length of
KCNE2 less milk (hypothyroidism of the dams impairs milk ejection), the milk they receive is deficient in T, and they themselves cannot adequately transport iodide into the thyroid. "Kcne2"-/- pups exhibit stunted growth, alopecia, cardiomegaly and reduced cardiac ejection fraction, all of which are alleviated by thyroid hormone supplementation of pups or dams. Surrogating "Kcne2"-/- pups with "Kcne2"+/+ dams also alleviates these phenotypes, highlighting the influence of maternal genotype in this case. As observed for hERG mutations, KCNE2 loss-of-function mutations are associated with inherited LQTS, and hERG-KCNE2 channels carrying the mutations show reduced activity compared to wild-type channels. In addition, some