Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous peoples of Florida Indigenous peoples of Florida The Indigenous peoples of Florida lived in what is now known as Florida for more than 12,000 years before the time of first contact with Europeans. However, the indigenous Floridians have largely died out with some completely by the early 18th century. Some Apalachees migrated to Louisiana, where their descendants now live, some were taken to Cuba and Mexico by the Spanish in the 18th century, and a few may have been absorbed into the Seminole and Miccosukee tribes. The first people arrived in Florida before the extinction of the Pleistocene megafauna. Human remains and/or artifacts