Dysphoric milk ejection reflex to nipple/areolar stimulation, thoughts of the baby or of breastfeeding, or overfull breasts, travels through both brain and bloodstream, causing emotional changes in the brain and the release of milk in the breast. Prolactin, released in a gradual wave that peaks after the beginning of a feeding, is responsible for continued milk production. Dopamine inhibits the release of prolactin, so dopamine levels must drop in order for prolactin levels to rise. Some speculate that the necessary dopamine drop is similar to (and timed with) the oxytocin spike – a sort of negative image – but that in D-MER mothers it
Corticotropin-releasing hormone receptor 1 II and urocortin III. Variations in the "CRHR1" gene is associated with enhanced response to inhaled corticosteroid therapy in asthma. CRF1 triggers cells to release hormones that are linked to stress and anxiety [original reference missing].Hence CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety. Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn. Corticotropin-releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone and Urocortin. Corticotropin-releasing hormone receptor 1 Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF, with the latter (CRF) now being the IUPHAR-recommended