Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Indigenous peoples of Mexico When the ethnic origins of the person were not known, phenotypic characteristics were relied upon to determine the status of the individual. Those that were in lower statuses had to pay more to the crown. When Mexico gained independence in 1821, the casta system was eliminated as a legal structure, but racial divides remained. White Mexican argued about what the solution was to the "Indian Problem", that is indigenous who continued to live in communities and were not integrated politically or socially as citizens of the new republic. The Mexican constitution of 1824 has several articles pertaining to indigenous peoples.