Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous people of the Everglades region powerful in number and political structure. Their territory was centered on modern-day Ft. Myers, and extended as far north as Tampa, as far east as Lake Okeechobee, and as far south as the Keys. The Tequesta lived on the southeastern coast of the Florida peninsula around what is today Biscayne Bay and the Miami River. Both societies were well adapted to live in the various ecosystems of the Everglades regions. Their people often traveled through the heart of the Everglades, though they rarely lived within it. After more than 210 years of relations with the Spanish, both indigenous societies lost