Refractory period (sex) for treating sexual dysfunction. Sildenafil, used in the treatment of erectile dysfunction, was found in one scientific study to have caused "a decreased postejaculatory erectile refractory time (3.2 ± 0.7 vs. 6.4 ± 0.7 minutes)" in men diagnosed with premature ejaculation. It is additionally proposed that the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions causes refractoriness of the post-ejaculatory refractory period. This hypothesis also supports the increase of oxytocin and prolactin after orgasm in accordance with the previous studies. One alternative theory explains the male refractory period in terms of a peripheral
Dysphoric milk ejection reflex and describe the phenomenon to lactation professionals in 2007. It was chosen due to the emotional reaction (dysphoria) to milk let-down (milk ejection reflex). The "milk ejection reflex" is abbreviated among lactation professionals and referred to as the M-E-R. This means that D-MER is not said DEE-MERE, but rather D.M.E.R, all the letters names said individually. In 2008 a team of lactation consultants, headed up by Diane Wiessinger, MS, IBCLC, LLLL worked together and consulted with other medical professionals to do a preliminary investigation to better understand D-MER. After the first published case study of D-MER, it became a more