Corrosive substance or slowly over days or years, e.g. the rusting of iron in a bridge. Sometimes the word caustic is used as a synonym for "corrosive", but "caustic" refers only to strong bases, particularly alkalis, and not to acids, oxidizers, or other non-alkaline corrosives. At low concentrations, a corrosive substance is called an irritant, and its effect on living tissue is called irritation. At high concentrations, a corrosive substance causes a chemical burn, a distinct type of tissue damage. Corrosives are different from poisons in that corrosives are immediately dangerous to the tissues they contact, whereas poisons may have systemic toxic
Substance P nitric oxide release. Substance P is involved in the axon reflex-mediated vasodilatation to local heating and wheal and flare reaction. It has been shown that vasodilatation to substance P is dependent on the NK1 receptor located on the endothelium. In contrast to other neuropeptides studied in human skin, substance P-induced vasodilatation has been found to decline during continuous infusion. This possibly suggests an internalization of neurokinin-1 (NK1). As is typical with many vasodilators, it also has bronchoconstrictive properties, administered through the non-adrenergic, non-cholinergic nervous system (branch of the vagal system). SP initiates expression of almost all known immunological chemical messengers