Pre-ignition Pre-ignition Pre-ignition (or preignition) in a spark-ignition engine is a technically different phenomenon from engine knocking, and describes the event wherein the air/fuel mixture in the cylinder ignites before the spark plug fires. Pre-ignition is initiated by an ignition source other than the spark, such as hot spots in the combustion chamber, a spark plug that runs too hot for the application, or carbonaceous deposits in the combustion chamber heated to incandescence by previous engine combustion events. The phenomenon is also referred to as 'after-run', or 'run-on' or sometimes dieseling, when it causes the engine to carry on running after
Carbohydrate-responsive element-binding protein Carbohydrate-responsive element-binding protein Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the "MLXIPL" gene. The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA. This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc / Max / Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. This gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of