Globalization and disease Eurasian diseases to the Americas was that many more native peoples were killed by disease and germs than by the colonists' use of guns or other weapons. Scholars estimate that over a period of four centuries, epidemic diseases wiped out as much as 90 percent of the American indigenous populations. In Europe during the age of exploration, diseases such as smallpox, measles and tuberculosis (TB) had already been introduced centuries before through trade with Asia and Africa. People had developed some antibodies to these and other diseases from the Eurasian continent. When the Europeans traveled to new lands, they carried
Indigenous peoples of Mexico When the ethnic origins of the person were not known, phenotypic characteristics were relied upon to determine the status of the individual. Those that were in lower statuses had to pay more to the crown. When Mexico gained independence in 1821, the casta system was eliminated as a legal structure, but racial divides remained. White Mexican argued about what the solution was to the "Indian Problem", that is indigenous who continued to live in communities and were not integrated politically or socially as citizens of the new republic. The Mexican constitution of 1824 has several articles pertaining to indigenous peoples.