Agave tequilana Through the 1990s, diseases spread, particularly "Fusarium" fungi and "Erwinia" bacteria, exacerbated by the low genetic diversity of the agave plants. Other problems include the agave weevil, "Scyphophorus acupunctatus", and a fungus, "Thielaviopsis paradoxa". According to a 2004 study, additional pathogens, "Erwinia carotovora", "Enterobacter agglomerans", "Pseudomonas mendocina", and "Serratia" spp. are responsible for continued rot. The homoisoflavanones 5,7-dihydroxy-3-(4-methoxybenzyl)-chroman-4-one, 7-hydroxy-3-(4-hydroxybenzyl)-chroman-4-one and 4’-demethyl-3,9-dihydro-punctatin can be isolated from "A. tequilana". Agave tequilana Agave tequilana, commonly called blue agave () or tequila agave, is an agave plant that is an important economic product of Jalisco, Mexico, due to its role as the base ingredient
Alcoholic drink and fat oxidation. Ethanol is directly processed in the liver to acetyl CoA, the same intermediate product as in glucose metabolism. Because ethanol is mostly metabolized and consumed by the liver, chronic excessive use can lead to fatty liver. This leads to a chronic inflammation of the liver and eventually alcoholic liver disease. The average number of people who drink was 39% for males and 25% for females (2.4 billion people in total). Females on average drink 0.7 drinks per day while males drink 1.7 drinks per day. The rates of drinking varies significantly in different areas of the world.