Population history of indigenous peoples of the Americas scope of the epidemics over the years was tremendous, killing millions of people—possibly in excess of 90% of the population in the hardest hit areas—and creating one of "the greatest human catastrophe in history, far exceeding even the disaster of the Black Death of medieval Europe", which had killed up to one-third of the people in Europe and Asia between 1347 and 1351. One of the most devastating diseases was smallpox, but other deadly diseases included typhus, measles, influenza, bubonic plague, cholera, malaria, tuberculosis, mumps, yellow fever and pertussis, which were chronic in Eurasia. This transfer of disease between the
Genocide of indigenous peoples Spanish and Mexican colonization and epidemics this number had decreased to 100,000. But from 1849 and up until 1890 the Indigenous population of California had fallen below 20,000, primarily because of the killings. At least 4,500 California Indians were killed between 1849 and 1870, while many more perished due to disease and starvation. 10,000 Indians were also kidnapped and sold as slaves. One California law made it legal to declare any jobless Indian a vagrant, then auction his services off for up to four months. And it permitted whites to force Indian children to work for them until they were