Myrsine knudsenii in 2010. Myrsine knudsenii Myrsine knudsenii, the Kokee colicwood, is a species of tree in the primrose family. It is endemic to the island of Kauai in Hawaii. It is threatened by habitat loss. This is a shrub or tree growing up to 4.5 meters tall with flowers occurring in clusters along the branches. It grows in moist forests dominated by "Acacia koa", "Metrosideros polymorpha", and "Dicranopteris linearis". It probably once occurred in several other types of ecosystem. There are three populations left, for a total of about 30 trees. It was federally listed as an endangered species of the
Nin Jiom Pei Pa Koa in 1962, and continue to manufacture and sell the product worldwide. "Pei pa koa" had annual sales of HK$350 million in 2014. A study at the China Academy of Traditional Chinese Medicine published in a 1994 article, "Pharmacological studies of nin jion pei pa koa", states that Nin Jiom Pei Pa Koa had significant cough relieving and sputum removing effects. In four acute or sub-acute inflammatory models, the anti-inflammatory effect was marked.." "Pei pa koa" is made up of a blend of herbal ingredients including the fritillary bulb ("Bulbus fritillariae cirrhosae", 川貝母), loquat leaf ("Eriobotrya japonica", 枇鈀葉), ladybell root ("Adenophora