Orgasm men are capable of achieving them is supported by men who have reported having multiple, consecutive orgasms, particularly without ejaculation. Males who experience dry orgasms can often produce multiple orgasms, as the refractory period is reduced. An increased infusion of the hormone oxytocin during ejaculation is believed to be chiefly responsible for the refractory period, and the amount by which oxytocin is increased may affect the length of each refractory period. Another chemical which is considered to be responsible for the male refractory period is prolactin, which represses dopamine, which is responsible for sexual arousal. Because of this, there is
Corticotropin-releasing hormone receptor 2 more potent at stimulating CRHR2 beta than CRHR2 alpha and CRHR2 gamma, suggesting that the N-terminal sequence is involved in the ligand-receptor interaction. Corticotropin-releasing hormone receptor 2 Corticotropin-releasing hormone receptor 2 (CRHR2) is a protein, also known by the IUPHAR-recommended name CRF, that is encoded by the CRHR2 gene and occurs on the surfaces of some mammalian cells. CRF receptors are type 2 G protein-coupled receptors for corticotropin-releasing hormone (CRH) that are resident in the plasma membranes of hormone-sensitive cells. CRH, a peptide of 41 amino acids synthesized in the hypothalamus, is the principal neuroregulator of the hypothalamic-pituitary-adrenal axis, signaling