Caduceus is a continuation of the older Indo-European dragon-slayer motif. Wilhelm Heinrich Roscher (1913) pointed out that the serpent as an attribute of both Hermes and Asclepius is a variant of the "pre-historic semi-chthonic serpent hero known at Delphi as Python", who in classical mythology is slain by Apollo. One Greek myth of origin of the caduceus is part of the story of Tiresias, who found two snakes copulating and killed the female with his staff. Tiresias was immediately turned into a woman, and so remained until he was able to repeat the act with the male snake seven years later.
Serpent (symbolism) of Moses transformed into a snake and then back into a staff (Exodus 4:2–4). The Book of Numbers 21:6–9 provides an origin for an archaic copper serpent, "Nehushtan" by associating it with Moses. This copper snake according to the Biblical text is wrapped around a pole and used for healing. Book of Numbers 21:9 "And Moses made a snake of copper, and put it upon a pole, and it came to pass, that if a snake had bitten any man, when he beheld the snake of brass, he lived." When the reformer King Hezekiah came to the throne of Judah