Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous languages of the Americas 18th and 19th centuries, Spanish, English, Portuguese, French, and Dutch, brought to the Americas by European settlers and administrators, had become the official or national languages of modern nation-states of the Americas. Many indigenous languages have become critically endangered, but others are vigorous and part of daily life for millions of people. Several indigenous languages have been given official status in the countries where they occur, such as Guaraní in Paraguay. In other cases official status is limited to certain regions where the languages are most spoken. Although sometimes enshrined in constitutions as official, the languages may be used infrequently