Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Indigenous peoples in Brazil while a person from India is called in order to distinguish the two. At the time of European contact, some of the indigenous people were traditionally mostly semi-nomadic tribes who subsisted on hunting, fishing, gathering and migrant agriculture. Many of the estimated 2,000 nations and tribes which existed in the 16th century suffered extinction as a consequence of the European settlement, and many were assimilated into the Brazilian population. The indigenous population was largely killed by European diseases, declining from a pre-Columbian high of millions to some 300,000 (1997), grouped into 200 tribes. However, the number could be much higher