Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous Australians island and the rest of mainland Australia during the last glacial period. Estimates of the population of the Aboriginal people of Tasmania, before European arrival, are in the range of 3,000 to 15,000 people although genetic studies have suggested significantly higher figures, which are supported by Indigenous oral traditions that indicate a reduction in population from diseases introduced by British and American sealers before settlement. The original population was further reduced to around 300 between 1803 and 1833 due to disease, warfare and other actions of British settlers. Despite over 170 years of debate over who or what was responsible