Population history of indigenous peoples of the Americas scope of the epidemics over the years was tremendous, killing millions of people—possibly in excess of 90% of the population in the hardest hit areas—and creating one of "the greatest human catastrophe in history, far exceeding even the disaster of the Black Death of medieval Europe", which had killed up to one-third of the people in Europe and Asia between 1347 and 1351. One of the most devastating diseases was smallpox, but other deadly diseases included typhus, measles, influenza, bubonic plague, cholera, malaria, tuberculosis, mumps, yellow fever and pertussis, which were chronic in Eurasia. This transfer of disease between the
Indigenous peoples in Uruguay territory was inhabited by small tribes of nomadic Charrua, Chana, Arachan and Guarani peoples. They were a semi-nomadic people who survived by hunting, fishing and gathering and probably never reached more than 10,000 – 20,000 people. It is estimated that there were about 9,000 Charrúa and 6,000 Chaná and Guaraní at the time of contact with the Spanish in the 1500s. By the time of independence, some 300 years later, there were only about 500 native peoples remaining in Uruguay. The cause of the decline in native populations was disease, as well as intermarriage. With little immunity to these diseases,