Globalization and disease Eurasian diseases to the Americas was that many more native peoples were killed by disease and germs than by the colonists' use of guns or other weapons. Scholars estimate that over a period of four centuries, epidemic diseases wiped out as much as 90 percent of the American indigenous populations. In Europe during the age of exploration, diseases such as smallpox, measles and tuberculosis (TB) had already been introduced centuries before through trade with Asia and Africa. People had developed some antibodies to these and other diseases from the Eurasian continent. When the Europeans traveled to new lands, they carried
Indigenous people of the Everglades region that Ponce de León was not the first Spaniard to make contact with the native people of Florida. During his second visit to South Florida, Ponce de León was killed by the Calusa, and the tribe gained a reputation for violence, causing future explorers to avoid them. In the more than 200 years the Calusa had relations with the Spanish, they were able to resist their attempts to missionize them. The Calusa were referred to as "Carlos" by the Spanish, which may have sounded like "Calos", a variation of the Muskogean word "kalo" meaning "black" or "powerful". Much of what