Orgasm men are capable of achieving them is supported by men who have reported having multiple, consecutive orgasms, particularly without ejaculation. Males who experience dry orgasms can often produce multiple orgasms, as the refractory period is reduced. An increased infusion of the hormone oxytocin during ejaculation is believed to be chiefly responsible for the refractory period, and the amount by which oxytocin is increased may affect the length of each refractory period. Another chemical which is considered to be responsible for the male refractory period is prolactin, which represses dopamine, which is responsible for sexual arousal. Because of this, there is
KCNE2 less milk (hypothyroidism of the dams impairs milk ejection), the milk they receive is deficient in T, and they themselves cannot adequately transport iodide into the thyroid. "Kcne2"-/- pups exhibit stunted growth, alopecia, cardiomegaly and reduced cardiac ejection fraction, all of which are alleviated by thyroid hormone supplementation of pups or dams. Surrogating "Kcne2"-/- pups with "Kcne2"+/+ dams also alleviates these phenotypes, highlighting the influence of maternal genotype in this case. As observed for hERG mutations, KCNE2 loss-of-function mutations are associated with inherited LQTS, and hERG-KCNE2 channels carrying the mutations show reduced activity compared to wild-type channels. In addition, some