Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Mexican Inquisition estimates that about 50 people were executed by the Mexican Inquisition. Included in that total are 29 people executed as "Judaizers" between 1571 and 1700 (out of 324 people prosecuted) for practicing the Jewish religion. The Mexican Inquisition was an extension of what had been going on in Spain and the rest of Europe for some time. Spanish Catholicism had been reformed under the reign of Isabella the Catholic (1479– 1504), which reaffirmed medieval doctrines and tightened up discipline and practice. She also introduced the Holy Office of the Inquisition in 1478 with the permission of Pope Sixtus IV, combining