Population history of indigenous peoples of the Americas scope of the epidemics over the years was tremendous, killing millions of people—possibly in excess of 90% of the population in the hardest hit areas—and creating one of "the greatest human catastrophe in history, far exceeding even the disaster of the Black Death of medieval Europe", which had killed up to one-third of the people in Europe and Asia between 1347 and 1351. One of the most devastating diseases was smallpox, but other deadly diseases included typhus, measles, influenza, bubonic plague, cholera, malaria, tuberculosis, mumps, yellow fever and pertussis, which were chronic in Eurasia. This transfer of disease between the
Indigenous people of the Everglades region that Ponce de León was not the first Spaniard to make contact with the native people of Florida. During his second visit to South Florida, Ponce de León was killed by the Calusa, and the tribe gained a reputation for violence, causing future explorers to avoid them. In the more than 200 years the Calusa had relations with the Spanish, they were able to resist their attempts to missionize them. The Calusa were referred to as "Carlos" by the Spanish, which may have sounded like "Calos", a variation of the Muskogean word "kalo" meaning "black" or "powerful". Much of what