Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Indigenous languages of the Americas 18th and 19th centuries, Spanish, English, Portuguese, French, and Dutch, brought to the Americas by European settlers and administrators, had become the official or national languages of modern nation-states of the Americas. Many indigenous languages have become critically endangered, but others are vigorous and part of daily life for millions of people. Several indigenous languages have been given official status in the countries where they occur, such as Guaraní in Paraguay. In other cases official status is limited to certain regions where the languages are most spoken. Although sometimes enshrined in constitutions as official, the languages may be used infrequently