Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Caeté people Caeté people The Caetés (Kaeté) were an indigenous people of Brazil, linguistically belonging to the Tupi people. The Tupi people were a large group of indigenous people who populated Brazil's coast, and they were among the first natives that the Portuguese encountered when they arrived at South America. The Tupi were divided into several tribes such as the: Tupiniquim, Tupinambá, Potiguara, Tabajara, Temiminó, Tamoios, and the Caeté. This tribe was estimated to contain approximately 300-2,000 people in the early 1500s, but their population eventually diminished greatly due to European diseases and slavery once the Portuguese began to settle in Brazil.