Chemical substance identity of benzene, until the correct structure was described by Friedrich August Kekulé. Likewise, the idea of stereoisomerism – that atoms have rigid three-dimensional structure and can thus form isomers that differ only in their three-dimensional arrangement – was another crucial step in understanding the concept of distinct chemical substances. For example, tartaric acid has three distinct isomers, a pair of diastereomers with one diastereomer forming two enantiomers. An element is a chemical substance made up of a particular kind of atom and hence cannot be broken down or transformed by a chemical reaction into a different element, though it
Chemical substance combined into one substance through a chemical reaction form a chemical compound. All compounds are substances, but not all substances are compounds. A chemical compound can be either atoms bonded together in molecules or crystals in which atoms, molecules or ions form a crystalline lattice. Compounds based primarily on carbon and hydrogen atoms are called organic compounds, and all others are called inorganic compounds. Compounds containing bonds between carbon and a metal are called organometallic compounds. Compounds in which components share electrons are known as covalent compounds. Compounds consisting of oppositely charged ions are known as ionic compounds, or salts.