Refractory period (sex) for treating sexual dysfunction. Sildenafil, used in the treatment of erectile dysfunction, was found in one scientific study to have caused "a decreased postejaculatory erectile refractory time (3.2 ± 0.7 vs. 6.4 ± 0.7 minutes)" in men diagnosed with premature ejaculation. It is additionally proposed that the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions causes refractoriness of the post-ejaculatory refractory period. This hypothesis also supports the increase of oxytocin and prolactin after orgasm in accordance with the previous studies. One alternative theory explains the male refractory period in terms of a peripheral
Refractory period (sex) through restoration of the wall tension in the seminal vesicles. As men age, the time to restore tension in the seminal vesicles increases. The female sexual response is more varied than that of men, and women are capable of attaining additional or multiple orgasms through further sexual stimulation. However, there are many women who experience clitoral hypersensitivity after orgasm, which can effectively create a refractory period. These women may be capable of further orgasms, but the pain involved in getting there makes the prospect undesirable. According to Havelock Ellis, most multi-orgasmic men (and their partners) report that multiple orgasms lead