Classical element to use the term "element (στοιχεῖον, "stoicheion")" in reference to air, fire, earth, and water. The ancient Greek word for element, "stoicheion" (from "stoicheo", "to line up") meant "smallest division (of a sun-dial), a syllable", as the composing unit of an alphabet it could denote a letter and the smallest unit from which a word is formed. A similar alphabetic metaphor may be the origin of the equivalent Latin word "elementum" (from which the English word comes), possibly based on the names of the letters 'l', 'm', and 'n', though the validity of this idea is debated. In his "On
Carbohydrate-responsive element-binding protein Carbohydrate-responsive element-binding protein Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the "MLXIPL" gene. The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA. This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc / Max / Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. This gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of