Refractory period (sex) for treating sexual dysfunction. Sildenafil, used in the treatment of erectile dysfunction, was found in one scientific study to have caused "a decreased postejaculatory erectile refractory time (3.2 ± 0.7 vs. 6.4 ± 0.7 minutes)" in men diagnosed with premature ejaculation. It is additionally proposed that the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions causes refractoriness of the post-ejaculatory refractory period. This hypothesis also supports the increase of oxytocin and prolactin after orgasm in accordance with the previous studies. One alternative theory explains the male refractory period in terms of a peripheral
Mammalian orthoreovirus some Reoviruses were not known to be associated with any diseases at the time of their discovery. The Reoviridae family is also characterized with "naked", icosahedral capsids and 10-12 segments of linear double stranded RNA. “Naked” meaning the icosahedral capsid is not surrounded by a viral envelope. Within the Reoviridae family the Mammalian orthoreovirus is a part of the Spinareovirinae subfamily. This is based on the fact that viruses within this subfamily, such as the Mammalian orthoreovirus, Aquareovirus, Coltivirus, Cypovirus, etc., have the presence of a turreted protein on the inner capsid. The etymology of the Mammalian orthoreovirus is based