Refractory period (sex) autonomic feedback mechanism, rather than through central chemicals like oxytocin, serotonin, and prolactin. Autonomic feedback is already known to regulate other physiologic systems, such as breathing, blood pressure, and gut motility. This theory suggests that after male ejaculation, decreased wall tension in structures such as the seminal vesicles leads to a change in the fine autonomic signals sent from these organs, effectively creating a negative feedback loop. Such a mechanism is similar to decreased gastric and bowel motility once gastric contents have passed through. Once the feedback loop has been created, the refractory period remains until the loop is broken
Corticotropin-releasing hormone receptor 2 more potent at stimulating CRHR2 beta than CRHR2 alpha and CRHR2 gamma, suggesting that the N-terminal sequence is involved in the ligand-receptor interaction. Corticotropin-releasing hormone receptor 2 Corticotropin-releasing hormone receptor 2 (CRHR2) is a protein, also known by the IUPHAR-recommended name CRF, that is encoded by the CRHR2 gene and occurs on the surfaces of some mammalian cells. CRF receptors are type 2 G protein-coupled receptors for corticotropin-releasing hormone (CRH) that are resident in the plasma membranes of hormone-sensitive cells. CRH, a peptide of 41 amino acids synthesized in the hypothalamus, is the principal neuroregulator of the hypothalamic-pituitary-adrenal axis, signaling