Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Indigenous people of the Everglades region that Ponce de León was not the first Spaniard to make contact with the native people of Florida. During his second visit to South Florida, Ponce de León was killed by the Calusa, and the tribe gained a reputation for violence, causing future explorers to avoid them. In the more than 200 years the Calusa had relations with the Spanish, they were able to resist their attempts to missionize them. The Calusa were referred to as "Carlos" by the Spanish, which may have sounded like "Calos", a variation of the Muskogean word "kalo" meaning "black" or "powerful". Much of what