Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
National Institute of Indigenous Peoples National Institute of Indigenous Peoples The National Institute of Indigenous Peoples (, INPI) is a decentralized agency of the Mexican Federal Public Administration. It was established on December 4, 2018, though the earliest Mexican government agency for indigenous matters was created in 1948. It is headquartered in Mexico City and headed by Adelfo Regino Montes. The National Indigenist Institute was established in 1948, with the initial goal of integrating indigenous people into the national culture. The agency carried out health and education campaigns, and it also relocated more than 22,000 people displaced by the construction of the Miguel Alemán Dam