Māori people peaceful tribes from their productive turangawaewae, such as the Moriori in the Chatham Islands by invading forces from North Taranaki, had a catastrophic effect on these conquered tribes. At the same time, the Māori suffered high mortality rates for new Eurasian infectious diseases, such as influenza, smallpox and measles, which killed an unknown number of Māori: estimates vary between ten and fifty percent. The spread of epidemics resulted largely from the Māori lacking acquired immunity to the new diseases. A huge influx of European settlers in the 1870s increased contact among many of the indigenous people with the newcomers. Te
Early-onset Alzheimer's disease 3.5% of total Alzheimer's disease, it has presented a useful model in studying various aspects of the disorder. Currently, the early-onset familial AD gene mutations guide the vast majority of animal model-based therapeutic discovery and development for AD. Alzheimer's disease (AD) is the most common cause of dementia and usually occurs in old age. It is invariably fatal, generally within 10 years of the first signs. Early signs of AD include unusual memory loss, particularly in remembering recent events and the names of people and things, logopenic primary progressive aphasia. As the disease progresses, the patient exhibits more serious problems,