Population history of indigenous peoples of the Americas scope of the epidemics over the years was tremendous, killing millions of people—possibly in excess of 90% of the population in the hardest hit areas—and creating one of "the greatest human catastrophe in history, far exceeding even the disaster of the Black Death of medieval Europe", which had killed up to one-third of the people in Europe and Asia between 1347 and 1351. One of the most devastating diseases was smallpox, but other deadly diseases included typhus, measles, influenza, bubonic plague, cholera, malaria, tuberculosis, mumps, yellow fever and pertussis, which were chronic in Eurasia. This transfer of disease between the
Mexican Inquisition estimates that about 50 people were executed by the Mexican Inquisition. Included in that total are 29 people executed as "Judaizers" between 1571 and 1700 (out of 324 people prosecuted) for practicing the Jewish religion. The Mexican Inquisition was an extension of what had been going on in Spain and the rest of Europe for some time. Spanish Catholicism had been reformed under the reign of Isabella the Catholic (1479– 1504), which reaffirmed medieval doctrines and tightened up discipline and practice. She also introduced the Holy Office of the Inquisition in 1478 with the permission of Pope Sixtus IV, combining