Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Mexican Americans an army to defend themselves from invading American forces after the Mexican army retreated from Alta California to defend other parts of Mexico. The Californios defeated an American force in Los Angeles on September 30, 1846. In turn, they were defeated after the Americans reinforced their forces in what is now southern California. Tens of thousands of miners and associated people arrived during the California Gold Rush, and their activities in some areas meant the end of the Californios' ranching lifestyle. Many of the English-speaking 49ers turned from mining to farming and moved, often illegally, onto land granted to Californios