Refractory period (sex) for treating sexual dysfunction. Sildenafil, used in the treatment of erectile dysfunction, was found in one scientific study to have caused "a decreased postejaculatory erectile refractory time (3.2 ± 0.7 vs. 6.4 ± 0.7 minutes)" in men diagnosed with premature ejaculation. It is additionally proposed that the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions causes refractoriness of the post-ejaculatory refractory period. This hypothesis also supports the increase of oxytocin and prolactin after orgasm in accordance with the previous studies. One alternative theory explains the male refractory period in terms of a peripheral
Dysphoric milk ejection reflex information currently available on D-MER. Also available through the website are an online media presentation on YouTube, a Facebook group with a message board and a Facebook page that sends links to the latest online information about D-MER to members' news feeds. The first documented reference to a hormonally based negative emotional reaction while breastfeeding was found online in a forum in June 2004. Prior to the launch of D-MER.org the phenomenon was unknown, unnamed, misunderstood and rarely mentioned or talked about. The term dysphoric milk ejection reflex (D-MER) came from Alia Macrina Heise who was the first to identify