Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Genocide of indigenous peoples in Brazil Genocide of indigenous peoples in Brazil The process that has been described as the genocide of indigenous peoples in Brazil began with the Portuguese colonization of the Americas, when Pedro Álvares Cabral made landfall in what is now the country of Brazil in 1500. This started the process that led to the depopulation of the indigenous peoples in Brazil, because of disease and violent treatment by European settlers, and their gradual replacement with colonists from Europe and Africa. This process has been described as a genocide, and continues into the modern era with the ongoing destruction of indigenous peoples of