Corrosive substance or slowly over days or years, e.g. the rusting of iron in a bridge. Sometimes the word caustic is used as a synonym for "corrosive", but "caustic" refers only to strong bases, particularly alkalis, and not to acids, oxidizers, or other non-alkaline corrosives. At low concentrations, a corrosive substance is called an irritant, and its effect on living tissue is called irritation. At high concentrations, a corrosive substance causes a chemical burn, a distinct type of tissue damage. Corrosives are different from poisons in that corrosives are immediately dangerous to the tissues they contact, whereas poisons may have systemic toxic
Substance dependence upon which a person has developed a dependence syndrome. When dependence has developed, cessation of substance use produces an unpleasant state, which promotes continued drug use through negative reinforcement; i.e., the drug is used to escape or avoid re-entering the associated withdrawal state. The withdrawal state may include physical-somatic symptoms (physical dependence), emotional-motivational symptoms (psychological dependence), or both. Chemical and hormonal imbalances may arise if the substance is not introduced. Psychological stress may also result if the substance is not re-introduced. Infants also suffer from substance withdrawal, known as Neonnatal Abstinence Syndrome (NAS) which has severe and life-threatening effects on