Lewis acids and bases studied chemical bonding. In 1923, Lewis wrote "An acid substance is one which can employ an electron lone pair from another molecule in completing the stable group of one of its own atoms." The Brønsted–Lowry acid–base theory was published in the same year. The two theories are distinct but complementary. A Lewis base is also a Brønsted–Lowry base, but a Lewis acid doesn't need to be a Brønsted–Lowry acid. The classification into hard and soft acids and bases (HSAB theory) followed in 1963. The strength of Lewis acid-base interactions, as measured by the standard enthalpy of formation of an adduct
Chemical substance research only: The cause of the difference in production volume is the complexity of the molecular structure of the chemical. Bulk chemicals are usually much less complex. While fine chemicals may be more complex, many of them are simple enough to be sold as "building blocks" in the synthesis of more complex molecules targeted for single use, as named above. The "production" of a chemical includes not only its synthesis but also its purification to eliminate by-products and impurities involved in the synthesis. The last step in production should be the analysis of batch lots of chemicals in order to