Māori people peaceful tribes from their productive turangawaewae, such as the Moriori in the Chatham Islands by invading forces from North Taranaki, had a catastrophic effect on these conquered tribes. At the same time, the Māori suffered high mortality rates for new Eurasian infectious diseases, such as influenza, smallpox and measles, which killed an unknown number of Māori: estimates vary between ten and fifty percent. The spread of epidemics resulted largely from the Māori lacking acquired immunity to the new diseases. A huge influx of European settlers in the 1870s increased contact among many of the indigenous people with the newcomers. Te
Early-onset Alzheimer's disease extremely rare. The majority of people with early-onset Alzheimer's are in their 50s or early 60s. The symptoms of the disease as a distinct nosologic entity were first identified by Emil Kraepelin, and the characteristic neuropathology was first observed by Alois Alzheimer in 1906. In this sense, the disease was co-discovered by Kraepelin and Alzheimer, who worked in Kraepelin's laboratory. Because of the overwhelming importance Kraepelin attached to finding the neuropathological basis of psychiatric disorders, Kraepelin made the decision that the disease would bear Alzheimer's name. Familial Alzheimer's disease (FAD) or early-onset familial Alzheimer's disease (EOFAD) is an uncommon form