Population history of indigenous peoples of the Americas scope of the epidemics over the years was tremendous, killing millions of people—possibly in excess of 90% of the population in the hardest hit areas—and creating one of "the greatest human catastrophe in history, far exceeding even the disaster of the Black Death of medieval Europe", which had killed up to one-third of the people in Europe and Asia between 1347 and 1351. One of the most devastating diseases was smallpox, but other deadly diseases included typhus, measles, influenza, bubonic plague, cholera, malaria, tuberculosis, mumps, yellow fever and pertussis, which were chronic in Eurasia. This transfer of disease between the
Indigenous people of Oaxaca warmer by the coast and in the Papaloapan region, which is part of the Gulf of Mexico coastal plain. Oaxaca is the historic home of the Zapotec and Mixtec peoples among others, and contains more speakers of indigenous languages than any other Mexican state. Excavations have shown that the region has had a settled population for at least 4,000 years. In the pre-Columbian period, the Zapotec developed an advanced civilization centered in Monte Alban in the central valley, which lasted between 300 BC and 700 AD. The state was expansionist, and extended its authority to the north, west, and southwest.