Agave maintenance once established. "Agave azul" (blue agave) is used in the production of tequila. In 2001, the Mexican Government and European Union agreed upon the classification of tequila and its categories. All 100% blue agave tequila must be made from the "Agave tequilana" 'Weber's Blue' agave plant, to rigorous specifications and only in certain Mexican states. The hybridized genus ×"Mangave" is created by cross-breeding species of "Manfreda" and "Agave". The ethnobotany of the agave was described by William H. Prescott in 1843: But the miracle of nature was the great Mexican aloe, or maguey, whose clustering pyramids of flowers, towering
Alcoholic drink and fat oxidation. Ethanol is directly processed in the liver to acetyl CoA, the same intermediate product as in glucose metabolism. Because ethanol is mostly metabolized and consumed by the liver, chronic excessive use can lead to fatty liver. This leads to a chronic inflammation of the liver and eventually alcoholic liver disease. The average number of people who drink was 39% for males and 25% for females (2.4 billion people in total). Females on average drink 0.7 drinks per day while males drink 1.7 drinks per day. The rates of drinking varies significantly in different areas of the world.