Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous peoples in Uruguay territory was inhabited by small tribes of nomadic Charrua, Chana, Arachan and Guarani peoples. They were a semi-nomadic people who survived by hunting, fishing and gathering and probably never reached more than 10,000 – 20,000 people. It is estimated that there were about 9,000 Charrúa and 6,000 Chaná and Guaraní at the time of contact with the Spanish in the 1500s. By the time of independence, some 300 years later, there were only about 500 native peoples remaining in Uruguay. The cause of the decline in native populations was disease, as well as intermarriage. With little immunity to these diseases,