Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous peoples of Mexico and Tzotzil Maya; Hidalgo with 36.21%, the majority being Otomi; Puebla with 35.28%, and Guerrero with 33.92%, mostly Nahua people and the states of San Luis Potosí and Veracruz both home to a population of 19% indigenous people, mostly from the Totonac, Nahua and Teenek (Huastec) groups. The majority of the indigenous population is concentrated in the central and southern states. According to the CDI, the states with the greatest percentage of indigenous population as of 2015 are: In 2011 a large scale mitochondrial sequencing in Mexican Americans revealed 85 to 90% of maternal mtDNA lineages are of Native American