Globalization and disease Spanish soldiers introduced smallpox by contact with natives of the Aztec capital Tenochtitlan. A devastating epidemic broke out among the indigenous people, killing thousands. In 1617, smallpox reached Massachusetts, probably brought by earlier explorers to Nova Scotia, Canada.” By 1638 the disease had broken out among people in Boston, Massachusetts. In 1721 people fled the city after an outbreak, but the residents spread the disease to others throughout the thirteen colonies. Smallpox broke out in six separate epidemics in the United States through 1968. The smallpox vaccine was developed in 1798 by Edward Jenner. By 1979 the disease had been
Indigenous people of the Everglades region powerful in number and political structure. Their territory was centered on modern-day Ft. Myers, and extended as far north as Tampa, as far east as Lake Okeechobee, and as far south as the Keys. The Tequesta lived on the southeastern coast of the Florida peninsula around what is today Biscayne Bay and the Miami River. Both societies were well adapted to live in the various ecosystems of the Everglades regions. Their people often traveled through the heart of the Everglades, though they rarely lived within it. After more than 210 years of relations with the Spanish, both indigenous societies lost