Dysphoric milk ejection reflex sense of depression and this feeling can range from mild homesickness or wistfulness to more intense feelings of hopelessness and self-loathing. Similarly, anxiety may range from restlessness to more intense panic and dread. Anger, the least likely of the three, may range from tension and agitation to more intense feelings of hostility and aggression. The mechanism is not clear. In a mother with D-MER, dopamine may fall inappropriately with milk release, causing the negative feelings. Among the hormones involved in milk production and release are oxytocin, prolactin, and dopamine. Oxytocin, released in pulsatile "spikes" from the posterior pituitary in response
Refractory period (physiology) a greater stimulus will be required to reach the initiation threshold for a second depolarization. The return to the equilibrium resting potential marks the end of the relative refractory period. The "refractory period" in cardiac physiology is related to the ion currents that, in cardiac cells as in nerve cells, flow into and out of the cell freely. The flow of ions translates into a change in the voltage of the inside of the cell relative to the extracellular space. As in nerve cells, this characteristic change in voltage is referred to as an action potential. Unlike that in nerve