Refractory period (sex) for treating sexual dysfunction. Sildenafil, used in the treatment of erectile dysfunction, was found in one scientific study to have caused "a decreased postejaculatory erectile refractory time (3.2 ± 0.7 vs. 6.4 ± 0.7 minutes)" in men diagnosed with premature ejaculation. It is additionally proposed that the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions causes refractoriness of the post-ejaculatory refractory period. This hypothesis also supports the increase of oxytocin and prolactin after orgasm in accordance with the previous studies. One alternative theory explains the male refractory period in terms of a peripheral
Dysphoric milk ejection reflex widely known and accepted condition with ongoing study being pursued by healthcare professionals. D-MER has been mentioned in several breastfeeding texts and self-help books since 2010 and awareness of this anomaly is steadily growing across the internet and within the medical community. References to D-MER can be found in the news , on blogs, Twitter and even Reddit. However, as of March 2014, there has been no scientific research studies involving mothers who experience D-MER to support the hypothesis that it is caused by the drop in dopamine just prior to the milk ejection reflex. There is a strong argument