Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Genocide of indigenous peoples considered genocide can be a matter of scholarly debate. Historians often draw on broader definitions such as Lemkin's, which sees colonialist violence against indigenous peoples as inherently genocidal. For example, in the case of the colonization of the Americas, where 90% of the indigenous people of the Americas were wiped out in 500 years of European colonization, it can be debatable whether genocide occurs when disease is considered the main cause of population decline since the introduction of disease was mostly unintentional. Some genocide scholars separate the population declines due to disease from the genocidal aggression of one group toward