Greek refugees the spread of the Hellenistic civilization in the 3rd century BC, Greek became the lingua franca of Asia Minor, and by the fifth century AD, when the last of the Indo-European native languages of Anatolia ceased to be spoken, Greek became the sole spoken language of the natives of Asia Minor. After the founding of Constantinople by the first Christian Roman Emperor Constantine the Great in 330, Asia Minor, the major part of the Greek East, became the most important region of the Eastern Roman (Byzantine) Empire. For the centuries to follow, the area was the main manpower and wheat
Near East Near East as far as the Red Sea, ceded India to the Asia and Oceania region, and went into partnership with North Africa as far as the Atlantic. The Ministry of Foreign Affairs of the Republic of Greece conducts "bilateral relationships" with the countries of the "Mediterranean – Middle East Region" but has formulated no Near East Region. The Ministry of Foreign Affairs of the Republic of Turkey also does not use the term "Near East". Its regions include the Middle East, the Balkans and others. The Ancient Near East is a term of the 20th century intended to stabilize