Globalization and disease Eurasian diseases to the Americas was that many more native peoples were killed by disease and germs than by the colonists' use of guns or other weapons. Scholars estimate that over a period of four centuries, epidemic diseases wiped out as much as 90 percent of the American indigenous populations. In Europe during the age of exploration, diseases such as smallpox, measles and tuberculosis (TB) had already been introduced centuries before through trade with Asia and Africa. People had developed some antibodies to these and other diseases from the Eurasian continent. When the Europeans traveled to new lands, they carried
Mexican Inquisition estimates that about 50 people were executed by the Mexican Inquisition. Included in that total are 29 people executed as "Judaizers" between 1571 and 1700 (out of 324 people prosecuted) for practicing the Jewish religion. The Mexican Inquisition was an extension of what had been going on in Spain and the rest of Europe for some time. Spanish Catholicism had been reformed under the reign of Isabella the Catholic (1479– 1504), which reaffirmed medieval doctrines and tightened up discipline and practice. She also introduced the Holy Office of the Inquisition in 1478 with the permission of Pope Sixtus IV, combining