Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous peoples of Mexico When the ethnic origins of the person were not known, phenotypic characteristics were relied upon to determine the status of the individual. Those that were in lower statuses had to pay more to the crown. When Mexico gained independence in 1821, the casta system was eliminated as a legal structure, but racial divides remained. White Mexican argued about what the solution was to the "Indian Problem", that is indigenous who continued to live in communities and were not integrated politically or socially as citizens of the new republic. The Mexican constitution of 1824 has several articles pertaining to indigenous peoples.