Indigenous peoples of the Americas Smallpox killed from one third to half of the native population of Hispaniola in 1518. By killing the Incan ruler Huayna Capac, smallpox caused the Inca Civil War of 1529–1532. Smallpox was only the first epidemic. Typhus (probably) in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, measles in 1618—all ravaged the remains of Inca culture. Smallpox killed millions of native inhabitants of Mexico. Unintentionally introduced at Veracruz with the arrival of Pánfilo de Narváez on April 23, 1520, smallpox ravaged Mexico in the 1520s, possibly killing over 150,000 in Tenochtitlán (the heartland of
Indigenous people of Oaxaca the Spanish in August 1521. The Spanish crown granted Oaxaca to the conquistador Hernán Cortés as his prize. The Spanish introduced new food such as wheat and sugar cane and new methods of cultivation. Diseases introduced by the Spanish greatly diminished the native population of Oaxaca, as did the insatiable appetite for gold, which led more and more Oaxacans into the dangerous mines. Over the 300 years of colonialism, many aspects of life became Europeanized. Important government positions were filled by the Spanish and their descendants, and later by elite mestizos, persons of mixed European and indigenous ancestry. However, Oaxaca