Gluten-related disorders disease patients who have HLA-DQ2 and HLA-DQ8. Coeliac disease (American English: celiac) (CD) is one of the most common chronic, immune-mediated disorders, triggered by the eating of gluten, a mixture of proteins found in wheat, barley, rye and derivatives. Evidence has shown that this condition not only has an environmental component but a genetic one as well, due to strong associations of CD with the presence of HLA (Human leukocyte antigen) type II, specifically DQ2 and DQ8 alleles. These alleles can stimulate a T cell, mediated immune response against tissue transglutaminase (TTG), an enzyme in the extracellular matrix, leading to
Wheat gluten (food) imported to the West in 1969 by the American company Erewhon. Wheat gluten is also called seitan (, ; Japanese: セイタン), mianjin (Chinese: 麵筋), milgogi(Korean: 밀고기), wheat meat, gluten meat, or simply gluten. Wheat gluten, called "miàn jīn" in Chinese (traditional: , simplified: , literally "dough tendon"; also spelled "mien chin" or "mien ching") is believed to have originated in ancient China, as a meat substitute for adherents of Buddhism, particularly some Mahayana Buddhist monks, who are strict vegetarians (see Buddhist cuisine). One story attributes the invention of imitation meat to chefs who made it for Chinese emperors who, traditionally,