Kinetic isotope effect both results are large enough to be indicative of weakening of the C-N bond in the transition state that would occur in a concerted process. Since kinetic isotope effects arise from differences in isotopic masses, the largest observable kinetic isotope effects are associated with isotopic substitutions of hydrogen with deuterium (100% increase in mass) or tritium (200% increase in mass). Kinetic isotope effects from isotopic mass ratios can be as large as 36.4 using muons. They have produced the lightest hydrogen atom, H (0.113 amu), in which an electron orbits around a positive muon (μ) "nucleus" that has a mass
Isotope geochemistry and origins of Earth systems. They are particularly useful to understand mixing processes between different components, because (heavy) radiogenic isotope ratios are not usually fractionated by chemical processes. Radiogenic isotope tracers are most powerful when used together with other tracers: The more tracers used, the more control on mixing processes. An example of this application is to the evolution of the Earth's crust and Earth's mantle through geological time. Lead has four stable isotopes - Pb, Pb, Pb, Pb and one common radioactive isotope Pb with a half-life of ~53,000 years. Lead is created in the Earth via decay of