Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
The Boston process approach of the main modifications are listed below: The Boston process approach is known to be a flexible battery approach when assessing brain function of a person, meaning that there can be many different standardized tests that can be administered to the individual depending on their existing deficiencies. Data interpretation from this approach does not necessarily look at the final score on the tests, rather it focuses on what kind of errors were made by the individual during the assessment. Results from the Boston process approach allow the clinician to make inferences about what brain areas may not be working properly