Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Electrical conduction system of the heart situated within the myocardium. There is a skeleton of fibrous tissue that surrounds the conduction system which can be seen on an ECG. Dysfunction of the conduction system can cause irregular, fast, or slow heart rhythms. Electrical signals arising in the SA node (located in the right atrium) stimulate the atria to contract. Then the signals travel to the atrioventricular node (AV node), which is located in the interatrial septum. After a delay, the electrical signal diverges and is conducted through the left and right bundle of His to the respective Purkinje fibers for each side of the heart, as