Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Pinky and the Brain Labs research facility. Brain is self-centered and scheming, Pinky is good-natured but feebleminded. In each episode, Brain devises a new plan to take over the world which ultimately ends in failure: usually due to Pinky's idiocy, the impossibility of Brain's plan, Brain's own arrogance, or just circumstances beyond their control. In common with many other "Animaniacs" shorts, many episodes are in some way a parody of something else, usually a film or novel. Many of the "Pinky and the Brain" episodes occur in the 1990s at Acme Labs, located in some large American city underneath a suspension bridge. Several episodes