Cardiovascular centre is detected by baroreceptors in the aortic sinuses or carotid sinuses, the cardiovascular centre affects changes to the heart rate by sending a nerve impulse to the cardiac pacemaker (or SA node) via sympathetic fibres (to cause faster and stronger cardiac muscle contraction) and the vagus nerve (to cause slower and less strong cardiac muscle contraction). The cardiovascular centre also increases the stroke volume of the heart (that is, the amount of blood it pumps). These two changes help to regulate the cardiac output, so that a sufficient amount of blood reaches tissue. Hormones like epinephrine and norepinephrine can affect
Cardiac neural crest cells of heart attacks include cardiac arrhythmias and heart failure. Although CNCCs are important in embryos, some CNCCs are retained in a dormant state to adulthood where they are called "neural crest stem cells". In 2005, Tomita transplanted neural crest stem cells from mammal hearts to the neural crest of chick embryos. These CNCCs were shown to migrate into the developing heart of the chick using the same dorsolateral pathway as the CNCCs, and differentiate into neural and glial cells. Tamura's study of 2011 examined the fate of CNCCs after a heart attack (myocardial infarction) in young mice. The CNCCs in