Glial scar brain and spinal cord. FGF2 has also been shown to increase astrocyte proliferation "in vitro". Ciliary neurotrophic factor (CNTF) is a cytosolic protein that is not secreted. CNTF has been shown to promote the survival of neuronal cultures "in vitro", and it can also act as a differentiator and trophic factor on glial cells. Further, CNTF has been previously shown to affect the differentiation of glial precursor cells "in vitro"; however, the influence of CNTF in the "in vivo" setting has only recently been determined. Winter "et al." used CNTF over-expressing transgenic mice as well as wildtype controls that had
Satellite glial cell these ganglia. In an SGC, the cell body is denoted by the region containing the single, relatively large nucleus. Each side of the cell body extends outward, forming perineuronal processes. The region containing the nucleus has the largest volume of cytoplasm, making this region of the SGC sheath thicker. The sheath can be even thicker if multiple SGCs are layered on top of one another, each measuring . Despite their flattened shape, satellite glial cells contain all common organelles necessary to make cellular products and to maintain the homeostatic environment of the cell. The plasma membrane of SGCs is thin