Radial glial cell the onset of gliogenesis, it is unclear whether they are involved in spinal cord neurogenesis or migration. Radial glia have also been implicated in forming boundaries between different axonal tracts and white matter areas of the brain. As radial glia serve as the primary neural and glial progenitors in the brain, as well as being crucial for proper neuronal migration, defects in radial glial function can have profound effects in the development of the nervous system. Mutations in either Lis1 or Nde1, essential proteins for radial glial differentiation and stabilization, cause the associated neurodevelopmental diseases Lissencephaly and micro-lissencephaly (which literally
Satellite glial cell these cells. Current research is revealing that SGCs are also able to respond to some of the same chemical stimuli as neurons. The research is ongoing and SGCs role in injury repair mechanisms is not yet fully understood. Glial cells, including SGCs, have long been recognized for their roles in response to neuronal damage and injury. SCGs have specifically been implicated in a new role involving the creation and persistence of chronic pain, which may involve hyperalgesia and other forms of spontaneous pain. SGCs have the ability to release cytokines and other bioactive molecules that transmit pain neuronally. Neurotrophins and