Sensory maps and brain development the midbrain auditory nucleus had receptive fields independent of nature and intensity of the sound. Roger Sperry proposed a chemical gradient model for eye rotation and for neuronal wiring diagram. Retinal neurons and target cells had identification tags in the form of chemical gradients so that the projection of neurons would be orderly. For a topographic map of the visual world, the map first forms during neural development via molecular signals, such as chemospecific matching between molecular gradients. The molecular basis of sensory maps and brain development is a field that is being actively explored. The most recent work has
Nanoparticles for drug delivery to the brain drug. Bolaamphiphile nano-vesicles can cross the BBB, and they allow controlled release of the drug to target sites. Lipoplexes can also be formed from cationic liposomes and DNA solutions, to yield transfection agents. Cationic liposomes cross the BBB through adsorption mediated endocytosis followed by internalization in the endosomes of the endothelial cells. By transfection of endothelial cells through the use of lipoplexes, physical alterations in the cells could be made. These physical changes could potentially improve how some nanoparticle drug-carriers cross the BBB. Metal nanoparticles are promising as carriers for drug delivery to the brain. Common metals used for nanoparticle