Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Pinky and the Brain (voiced by Maurice LaMarche). In "What Ever Happened to Baby Brain", Brain actually crosses paths, who is working as a busboy in a hollywood restaurant, they find themselves inadvertently yelling in unison, "Things will be different when I take over the world!" In "Project B.R.A.I.N." Brain's name is the backronym for the eponymous project: "Biological Recombinant Algorithmic Intelligence Nexus". His tail is angular and bent —he often uses it to pick the lock of the cage—and his head is large and wide, housing his abnormally large brain. He is highly intelligent and develops complex plans for global domination using politics,