Dead Brain Cells Dead Brain Cells Dead Brain Cells are a Canadian thrash metal band from the late 1980s. Called DBC for short, the band started in 1985 in Montreal as a small project named Final Chapter by guitar players Eddie Shahini and Gerry Ouellette, who put an ad in a magazine looking for a drummer. In 1986, former Vomit and the Zits singer Dave Javex Ray-O-Vac (David Leone) and former Unruled and Vomit and the Zits drummer Jeff Saint-Louis, joined with Shahini and Ouellette and guitar player Phil Dakin, who switched to bass. The project grew into a serious band which took
Nanoparticles for drug delivery to the brain constituents bind to nanoparticles, and then this complex binds to a low-density lipoprotein receptor (LDLR) in the BBB and allows transport to occur. The mechanism for the transport of polymer-based nanoparticles across the BBB has been characterized as receptor-mediated endocytosis by the brain capillary endothelial cells. Transcytosis then occurs to transport the nanoparticles across the tight junction of endothelial cells and into the brain. Surface coating nanoparticles with surfactants such as polysorbate 80 or poloxamer 188 was shown to increase uptake of the drug into the brain also. This mechanism also relies on certain receptors located on the luminal surface