Glial fibrillary acidic protein was described. Patients with GFAP astrocytopathy developed meningoencephalomyelitis with inflammation of the meninges, the brain parenchyma, and the spinal cord. About one third of cases were associated with various cancers and many also expressed other CNS autoantibodies. There are multiple disorders associated with improper GFAP regulation, and injury can cause glial cells to react in detrimental ways. Glial scarring is a consequence of several neurodegenerative conditions, as well as injury that severs neural material. The scar is formed by astrocytes interacting with fibrous tissue to re-establish the glial margins around the central injury core and is partially caused by up-regulation
Satellite glial cell structure very similar to the cilia of neurons, Schwann cells, and astrocytes of the CNS. Satellite glial cells in sensory ganglia are laminar cells that most often an envelope of multiple SGCs completely surrounds each sensory neuron. The number of SGCs that make up the sheath increases proportionately with the volume of the neuron which it surrounds. Additionally, the volume of the sheath itself increases proportionately with the volume and surface area of the neuron’s somata. The distance of extracellular space between the sheath and the neuronal plasma membrane measures , allowing the neuron and its SGC sheath to form