Oryza sativa sprang from a single domestication that occurred 8,200–13,500 years ago in China of the wild rice "Oryza rufipogon". A 2012 study, through a map of rice genome variation, indicated that the domestication of rice occurred in the Pearl River valley region of China. From East Asia, rice was spread to South and Southeast Asia. Before this research, the commonly accepted view, based on archaeological evidence, is that rice was first domesticated in the region of the Yangtze River valley in China. The precise date of the first domestication is unknown, but depending on the molecular clock estimate, the date is
Arogenate dehydratase hybrida", "Sorghum bicolor"", "and "Oryza sativa"", "which are all considered higher-order plants. "Erwinia herbicola"" and Pseudomonas aeruginosa"" "are known to" "have homologues for cyclohexadienyl dehydratase. Of the plants with ADT homologues, both "Arabidopsis thaliana "and "Petunia hybrida "are known to have paralogues for the gene (six and three, respectively). Arogenate dehydratase Arogenate dehydratase (ADT) (EC 4.2.1.91) is an enzyme that catalyzes the chemical reaction Hence, this enzyme has one substrate, L-arogenate, but 3 products:L-phenylalanine, HO, and CO. Certain forms of the protein have the potential to catalyze a second reaction, L-prephenate → L-phenylpyruvate + HO + CO This enzyme participates