Sam Schmidt Paralysis Foundation a cell body, which houses the nucleus. Axons and dendrites form extensions from the cell body. Glial cells are "nerve-helper" cells that provide structural support, nourishment and protection for neurons. Astrocytes, a kind of glial cell, are the primary support cells of the brain and spinal cord. They make and secrete proteins called neurotrophic factors, which assist in the maintenance of nerve cells in the central nervous system. They also break down and remove proteins or chemicals that might be harmful to neurons (for example, glutamate, a neurotransmitter that in excess causes cells to become overexcited and die by a
Glial scar animal). Further, a reduction in astrocytes and microglia, as well as a reduction in inflammation and angiogenesis, were observed. Interleukin-6 (IL-6) is thought to be a molecular mediator of glial scar formation. It has been shown to promote differentiation of neural stem cells into astrocytes. A monoclonal antibody, MR16-1, has been used to target and block the IL-6 receptors in rat spinal cord injury models. In a study by Okada "et al.", mice were intraperitoneally injected with a single dose of MR16-1 immediately after generating a spinal cord injury. Blockade of IL-6 receptors decreased the number of astrocytes present at