Derailleur gears operates the lever while pedalling, the change in cable tension moves the chain-guide from side to side, "derailing" the chain onto different sprockets. For more information about the choice of particular gear ratios and sprocket sizes, see Bicycle gearing. "Derailleur" is a French word, spelled "dérailleur" in French, derived from the derailment of a train from its tracks. Its first recorded use was 1930. At least one notable bicycle industry author has attempted to promote the anglicized spelling of "derailer". As of 2013, however, neither Merriam-Webster nor the Oxford English Dictionary has an entry for "derailer". Various derailleur systems were
Mechanism of action inflammation. This mechanism of action is specific to aspirin, and is not constant for all nonsteroidal anti-inflammatory drugs (NSAIDs). Rather, aspirin is the only NSAID that irreversibly inhibits COX-1. Some drug mechanisms of action are still unknown. However, even though the mechanism of action of a certain drug is unknown, the drug still functions; it is just unknown or unclear how the drug interacts with receptors and produces its therapeutic effect. In some literature articles, the term mechanism of action and mode of action (MoA) are used interchangeably; typically referring to the way in which the drug interacts and produces