Sterilization (microbiology) equal to the probability of a non-sterile unit. For high-risk applications, such as medical devices and injections, a sterility assurance level of at least 10 is required by the United States Food and Drug Administration (FDA). A widely used method for heat sterilization is the autoclave, sometimes called a converter or steam sterilizer. Autoclaves use steam heated to under pressure. To achieve sterility, the article is placed in a chamber and heated by injected steam until the article reaches a temperature and time setpoint. Almost all the air is removed from the chamber, because air is undesired in the moist
Meaning (philosophy of language) refine and/or refute proposed meanings and truths. Though not widely known, a new variation of the pragmatic theory was defined and wielded successfully from the 20th century forward. Defined and named by William Ernest Hocking, this variation is known as "negative pragmatism". Essentially, what works may or may not be true, but what fails cannot be true because the truth and its meaning always works. James and Dewey's ideas also ascribe meaning and truth to repeated testing which is "self-corrective" over time. Pragmatism and negative pragmatism are also closely aligned with the coherence theory of truth in that any testing