Charles Stent Charles Stent Charles Stent (1807–1885) was a 19th-century English dentist notable for his advances in the field of denture making. In 1847, Edwin Truman introduced gutta-percha as a material for making dental impressions; however, this was unsatisfactory for several reasons, including its tendency to distort upon removal from the patient's mouth, and to shrink upon cooling. In 1856, Stent added several other materials to the gutta-percha, notably stearine, which markedly improved the plasticity of the material as well as its stability. He also added talc as an inert filler to give more body to the material, and red colouring. The
Drug-eluting stent or both of these drugs after drug-eluting stenting markedly increases the risk of stent thrombosis and myocardial infarction. A recent histopathology study showed very late DES thrombosis is associated with histopathological signs of inflammation and intravascular ultrasound evidence of vessel remodeling. Compared with other causes of myocardial infarction, eosinophilic infiltrates are more common in thrombi harvested from very late DES thrombosis and correlate with the extent of stent malapposition. Whether drug-eluting stents are at higher risk than bare-metal stents for late thrombosis is intensely debated. In meta-analyses of the sirolimus- and paclitaxel-eluting stent trials, a small but statistically higher risk