Tree from the cinchona tree ("Cinchona") and was for a long time the remedy of choice for the treatment of malaria. Aspirin was synthesised to replace the sodium salicylate derived from the bark of willow trees ("Salix") which had unpleasant side effects. The anti-cancer drug Paclitaxel is derived from taxol, a substance found in the bark of the Pacific yew ("Taxus brevifolia"). Other tree based drugs come from the paw-paw ("Carica papaya"), the cassia ("Cassia spp."), the cocoa tree ("Theobroma cacao"), the tree of life ("Camptotheca acuminata") and the downy birch ("Betula pubescens"). The papery bark of the white birch tree
Beech bark disease to spread to the south and west. The first case of beech bark disease in the United States was reported in 1929 in Massachusetts. By 2004, the disease had spread as far west as Michigan and as far south as western North Carolina. For beech bark disease to occur, two components are required, an insect and a fungus. The beech scale insect, "Cryptococcus fagisuga", is invasive to North America and is host-specific, feeding exclusively on beech trees. It can be observed on the trunk and limbs of the tree as woolly, white tufts that will later develop into broad strips.