Cardiac pacemaker controls the rate of contraction for the entire heart muscle because its cells have the quickest rate of spontaneous depolarization, thus they initiate action potentials the quickest. The action potential generated by the SA node passes down the electrical conduction system of the heart, and depolarizes the other potential pacemaker cells (AV node) to initiate action potentials before these other cells have had a chance to generate their own spontaneous action potential, thus they contract and propagate electrical impulses to the pace set by the cells of the SA node. This is the normal conduction of electrical activity in the
Isovolumetric contraction Isovolumetric contraction In cardiac physiology, isovolumetric contraction is an event occurring in early systole during which the ventricles contract with no corresponding volume change (isovolumetrically). This short-lasting portion of the cardiac cycle takes place while all heart valves are closed. In a healthy young adult, blood enters the atria and flows to the ventricles via the opened atrioventricular valves (tricuspid and mitral valves). Atrial contraction rapidly follows, actively pumping about 20% of the returning blood. As diastole ends, the ventricles begin depolarizing and, while ventricular pressure starts to rise owing to contraction, the atrioventricular valves close in order to prevent