Kinetic isotope effect both results are large enough to be indicative of weakening of the C-N bond in the transition state that would occur in a concerted process. Since kinetic isotope effects arise from differences in isotopic masses, the largest observable kinetic isotope effects are associated with isotopic substitutions of hydrogen with deuterium (100% increase in mass) or tritium (200% increase in mass). Kinetic isotope effects from isotopic mass ratios can be as large as 36.4 using muons. They have produced the lightest hydrogen atom, H (0.113 amu), in which an electron orbits around a positive muon (μ) "nucleus" that has a mass
Hydrogen isotope biogeochemistry today's deuterium originated from this proton-proton fusion after sufficient cooling. Tritium, or hydrogen-3, with one proton and two neutrons, was produced by proton and neutron collisions in the early universe as well, but it has since radioactively decayed to helium-3. Modern tritium cannot be explained by big bang nucleosynthesis because of tritium's short half-life of 12.3 years. Today's tritium concentration is instead governed by nuclear reactions and cosmic rays. The radioactive beta decay of tritium to helium releases an electron and an antineutrino, with an average energy release of 18.6 MeV. It is important to note that this is classified