Radial glial cell and OPCs can be generated from radial glial cells "in vitro", more evidence is yet needed to conclude whether this process also occurs in the developing brain. Recently, radial glia that exclusively generate upper-layer cortical neurons have also been discovered. Since upper cortical layers have expanded greatly in recent evolution, and are associated with higher-level information processing and thinking, radial glia have been implicated as important mediators of brain evolution. The best characterized and first widely accepted function of radial glia is their role as scaffolds for neuronal migration in the cerebral and cerebellar cortexes. This role can be easily
Satellite glial cell in the same sheath (reflexive gap junctions). These gap junctions have been identified through the use of electron microscopy and weight tracer markers, such as Lucifer yellow or neurobiotin. The degree to which SGCs are coupled to SGCs of another sheath or to SGCs of the same sheath is dependent on the pH of the cellular environment. From studies on rats and mice, researchers have found that satellite glial cells express many neurotransmitter receptors, such as muscarinic acetylcholine and erythropoietin receptors. In order to differentiate between SGCs and other glial cells researchers have used markers to identify which proteins are