Ten percent of the brain myth 20th century. For example, the functions of many brain regions (especially in the cerebral cortex) are complex enough that the effects of damage are subtle, leading early neurologists to wonder what these regions did. The brain was also discovered to consist mostly of glial cells, which seemed to have very minor functions. James W. Kalat, author of the textbook "Biological Psychology", points out that neuroscientists in the 1930s knew about the large number of "local" neurons in the brain. The misunderstanding of the function of local neurons may have led to the ten percent myth. The myth might have been
Nanoparticles for drug delivery to the brain that it can bind and undergo endocytosis. Another mechanism is "adsorption mediated transcytosis", where electrostatic interactions are involved in mediating nanoparticle crossing of the BBB. Cationic nanoparticles (including cationic liposomes) are of interest for this mechanism, because their positive charges assist binding on the brain's endothelial cells. Using TAT-peptides, a cell-penetrating peptide, to functionalize the surface of cationic nanoparticles can further improve drug transport into the brain. In contrast to the above mechanisms, a delivery with magnetic fields doesn't strongly depend on the biochemistry of the brain. In this case, nanoparticles are literally pulled across the BBB via application of