Serpula himantioides due to a lack of any above ground symptoms of disease. Signs of the pathogen include basidiospores, and fungal masses that are generally dark brown and membranous in the center but become thin white mycelium towards edges of the mass. The brown cubical rot caused by "S. himantioides" resembles the rots of "Phaeolus schweinitzii" and "S. lacrymans". "Serpula himantiodes" is a pre-harvest pathogen that exerts economic impact on lumber supply. It is considered the wild sister species of "S. lacrymans", the pathogen that causes dry rot in wooden building structures. "S. himantioides" is studied most frequently in the context of
Serpula lacrymans of 13805 genes. "S. lacrymans"' genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4, NPS7, NPS13-NPS15, NPS17, and NPS18), and two hybrids thereof (NPS6, NPS8, and NPS16). Additionally, the genome encodes for various putative adenylate-forming reductases (NPS5, NPS9-NPS12) (Eastwood et al., 2011). "NPS3" was overexpressed in E. coli and characterized as an atromentin/quinone synthetase that catalyzes the formation of atromentin, similar to GreA; InvA1,2 and 5; and AtrA from Suillus grevillei, Tapinella panuoides, Paxillus involutus, respectively. "NPS3" and its adjacent clustered aminotransferase gene ("AMT1") were also found to be up-regulated during co-incubation with bacteria (Tauber et al.,