Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Pinky, Elmyra & the Brain sitcom "more like "The Simpsons"". In a press release, Warner Bros. stated that the new series was "a fresh approach to popular favorites as Pinky & The Brain move from ACME Labs to America's suburbs when they are adopted by the extremely excitable Elmyra." The idea was reportedly met with resistance from the producers of the series. The apparent dissatisfaction with Warner Bros.' decision to change "Pinky and the Brain" showed up in episodes. The last script that producer Peter Hastings wrote before leaving Warner Bros. for Disney was the episode "You'll Never Eat Food Pellets in This Town Again",