Glial cell line-derived neurotrophic factor and is the first member of the GDNF family of ligands (GFL) found. Glial cell line-derived neurotrophic factor has been shown to interact with GFRA2 and GDNF family receptor alpha 1. GDNF has regenerative properties for brain cells and showed potential as treatment for Parkinson's disease - monkeys with an induced form of Parkinson's disease showed less trembling when treated with the drug, and neuronal fibres grew in part of the human brain exposed to the drug. However progress to a treatment is hampered by the problem of delivering the drug to brain cells through the blood-brain barrier in human.
Guidepost cells of pioneer axons to the septum towards the contralateral hemisphere. The "glial sling" is a second set, located at the corticoseptal boundary, which provide cellular substrates for callosal axon migration across the dorsal midline. The "glial wedge" is made up of radial fibers, secreting repellent cues to prevent axons from entering the septum and positioning them towards the corpus callosum. The last set of glial cells, located in the induseum griseum, control the positioning of pioneer cingulate neurons in the corpus callosum region. Guidepost cells Guidepost cells are cells which assist in the subcellular organization of both neural axon growth