Native Americans in the United States reached the West Coast in the 1770s, smallpox rapidly killed at least 30% of Northwest Coast Native Americans. For the next eighty to one hundred years, smallpox and other diseases devastated native populations in the region. Puget Sound area populations, once estimated as high as 37,000 people, were reduced to only 9,000 survivors by the time settlers arrived en masse in the mid-19th century. Smallpox epidemics in 1780–82 and 1837–38 brought devastation and drastic depopulation among the Plains Indians. By 1832, the federal government established a smallpox vaccination program for Native Americans ("The Indian Vaccination Act of 1832"). It was
Chinese Americans Quincy area. San Francisco, California has the highest per capita concentration of Chinese Americans of any major city in the United States, at an estimated 21.4%, or 172,181 people, and contains the second-largest total number of Chinese Americans of any U.S. city. San Francisco's Chinatown was established in the 1840s, making it the oldest Chinatown in North America and one of the largest neighborhoods of Chinese people outside of Asia, composed in large part by immigrants hailing from Guangdong province and also many from Hong Kong. The San Francisco neighborhoods of Sunset District and Richmond District also contain significant Chinese