Gluten immunochemistry to react with gamma gliadin to a degree comparable to DQ2.5. T-cell responses to the high molecular weight glutenin may be more important with DQ8 mediated than DQ2.5 mediated celiac disease. Antibody recognition of gluten is complex. Direct binding to gluten such as anti-gliadin antibodies has an ambiguous pathogenesis in coeliac disease. The crosslinking of gliadin with tissue transglutaminase leads to the production of anti-transglutaminase antibodies, but this is mediated through T-cell recognition of gliadin. The allergic recognition of gliadin by mast cells, eosinophiles in the presence of IgE has notable direct consequences, such as exercise-induced anaphylaxis. Anti-gliadin antibodies, like
Wheat gluten (food) imported to the West in 1969 by the American company Erewhon. Wheat gluten is also called seitan (, ; Japanese: セイタン), mianjin (Chinese: 麵筋), milgogi(Korean: 밀고기), wheat meat, gluten meat, or simply gluten. Wheat gluten, called "miàn jīn" in Chinese (traditional: , simplified: , literally "dough tendon"; also spelled "mien chin" or "mien ching") is believed to have originated in ancient China, as a meat substitute for adherents of Buddhism, particularly some Mahayana Buddhist monks, who are strict vegetarians (see Buddhist cuisine). One story attributes the invention of imitation meat to chefs who made it for Chinese emperors who, traditionally,