Glial cell line-derived neurotrophic factor and is the first member of the GDNF family of ligands (GFL) found. Glial cell line-derived neurotrophic factor has been shown to interact with GFRA2 and GDNF family receptor alpha 1. GDNF has regenerative properties for brain cells and showed potential as treatment for Parkinson's disease - monkeys with an induced form of Parkinson's disease showed less trembling when treated with the drug, and neuronal fibres grew in part of the human brain exposed to the drug. However progress to a treatment is hampered by the problem of delivering the drug to brain cells through the blood-brain barrier in human.
Carotid body sustentacular supportive cells. The carotid body contains the most vascularized tissue in the human body . The thyroid gland is very vascular, but not quite as much as the carotid body. The carotid body functions as a sensor: it responds to a stimulus, primarily O partial pressure, which is detected by the type I (glomus) cells, and triggers an action potential through the afferent fibers of the glossopharyngeal nerve, which relays the information to the central nervous system. The carotid body chemoreceptors are primarily sensitive to decreases in the partial pressure of oxygen (P). This is in contrast to the