Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Process tomography imaging methods are used in process tomography, e.g. ultrasonic imaging, positron emission tomography (PET), electrical resistance tomography (ERT) and electrical impedance tomography (EIT), electrical capacitance tomography (ECT), magnetic induction tomography (MIT). In all cases external sensors are used to detect signals from boundary of the object, and the three-dimensional material distribution or the velocity field is computed using the measured data. Process tomography is an area of rapid growth both in terms of research and applications. There are number of challenges remaining in this area including data processing an image reconstruction, and application of imaging modalities in a real applications.