James Bayley Butler with the Royal Army Medical Corps, beginning as a lieutenant in 1915 and retiring a major after the war. For his service, he was awarded an MBE. Butler's primary research interest was in applied biology. He carried out research on "Catenaria anguillulae", a parasite of the ova of the liver fluke, from 1922 to 1932. Later on, Butler focused on the control of wood-boring beetles and the fungus that causes dry rot in wood "Serpula lacrymans". On this matter, he became an international expert, and assisted in the development of the company Biotox, which manufactured insecticides and fungicides for use
Serpula lacrymans of 13805 genes. "S. lacrymans"' genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4, NPS7, NPS13-NPS15, NPS17, and NPS18), and two hybrids thereof (NPS6, NPS8, and NPS16). Additionally, the genome encodes for various putative adenylate-forming reductases (NPS5, NPS9-NPS12) (Eastwood et al., 2011). "NPS3" was overexpressed in E. coli and characterized as an atromentin/quinone synthetase that catalyzes the formation of atromentin, similar to GreA; InvA1,2 and 5; and AtrA from Suillus grevillei, Tapinella panuoides, Paxillus involutus, respectively. "NPS3" and its adjacent clustered aminotransferase gene ("AMT1") were also found to be up-regulated during co-incubation with bacteria (Tauber et al.,