Cardiac action potential action potential (see phase 2, below) and is a fundamental step in cardiac excitation-contraction coupling. There are important physiological differences between the cells that spontaneously generate the action potential (pacemaker cells; e.g. SAN) and those that simply conduct it (non-pacemaker cells; e.g. ventricular myocytes). The specific differences in the types of ion channels expressed and mechanisms by which they are activated results in differences in the configuration of the action potential waveform, as shown in figure 2. The standard model used to understand the cardiac action potential is that of the ventricular myocyte. Outlined below are the five phases of
Cardiac cycle Cardiac cycle The cardiac cycle is the performance of the human heart from the beginning of one heartbeat to the beginning of the next. It consists of two periods: one during which the heart muscle relaxes and refills with blood, called diastole (die-ASS-toe-lee), followed by a period of robust contraction and pumping of blood, dubbed systole (SIS-toe-lee). After emptying, the heart immediately relaxes and expands to receive another influx of blood "returning from" the lungs and other systems of the body, before again contracting to "pump blood to" the lungs and those systems. A normally performing heart must be fully