Crossover experiment (chemistry) or phosphine. The mechanisms of enzyme-catalyzed reactions can also be studied using crossover experiments. Examples of the application of this technique in biochemistry include the study of reactions catalyzed by nucleoside diphosphohexose-4,6-dehydratases, the aconitase-catalyzed elimination of water from citrate, and various reactions catalyzed by coenzyme B-dependent enzymes, among others. Unlike isotope labeling studies in organic and organometallic chemistry, which typically use deuterium when an isotope of hydrogen is desired, biochemical crossover experiments frequently employ tritium. This is due to the fact that tritium is radioactive and can be tracked using the autoradiographs of gels in gel electrophoresis. Isotope labeling experiments
On-Line Isotope Mass Separator or to the REX accelerator for acceleration to higher energies. The facility is operated by the ISOLDE Collaboration comprising CERN and 9 European countries. One of the major experiments in ISOLDE is the Miniball-setup. An upgrade of the post-acceleration system is currently on-going, ready to produce energetic Radioactive-Ion Beams (RIBs) of up to 10 MeV per nucleon in 2018. On-Line Isotope Mass Separator The On-Line Isotope Mass Separator, also known as the ISOLDE Radioactive Ion Beam Facility, is a facility located at CERN on the PS Booster. It started operating in 1967 and was rebuilt twice with major upgrades in