Anti-transglutaminase antibodies antigen, presented by MHC molecules (HLA in humans) on antigen-reactive B-cells. These T-helper cells then stimulate B-cells to multiply and mature into plasma cells that make IgA and IgG to that protein. In the case of celiac disease, the current understanding is that tTG autoimmunity arises when T-cells are generated against wheat gliadin and similar gluten proteins made by a class of grasses called "Triticeae", which includes wheat (See Wheat taxonomy), barley, and rye. The T-cells are defined by the ability to react to HLA-DQ8 and DQ2.5 restricted antigens and gliadin is one of the antigens. Gliadin is a favored
Gluten-free, casein-free diet cream topping, which use casein to provide texture. Although advocates of the GFCF diet often recommend total elimination of dairy from the diet, whey protein is a different milk protein from casein. Gluten-free, casein-free diet Gluten-free casein-free diet (GFCF diet), also known as gluten-free dairy-free diet (GFDF diet), is a diet that does not include the proteins gluten (found most often in wheat, barley, and rye), and casein (found most often in milk and dairy products). Despite an absence of scientific evidence, there have been advocates for the use of this diet as a treatment for autism and related conditions.