Kinetic Isotope Effects of RuBisCO carbon, oxygen, and/or hydrogen, though currently only a significant isotope effect is seen for carbon isotope substitution. Isotopes are atoms that have the same number of protons but varying numbers of neutrons. "Lighter" isotopes (like the stable Carbon-12 isotope) have a smaller overall mass, and "heavier" isotopes (like the stable Carbon-13 isotope or radioactive Carbon-14 isotope) have a larger overall mass. Stable isotope geochemistry is concerned with how varying chemical and physical processes preferentially enrich or deplete stable isotopes. Enzymes like RuBisCO cause isotopic fractionation because molecules containing lighter isotopes have higher zero-point energies (ZPE), the lowest possible quantum energy
On-Line Isotope Mass Separator or to the REX accelerator for acceleration to higher energies. The facility is operated by the ISOLDE Collaboration comprising CERN and 9 European countries. One of the major experiments in ISOLDE is the Miniball-setup. An upgrade of the post-acceleration system is currently on-going, ready to produce energetic Radioactive-Ion Beams (RIBs) of up to 10 MeV per nucleon in 2018. On-Line Isotope Mass Separator The On-Line Isotope Mass Separator, also known as the ISOLDE Radioactive Ion Beam Facility, is a facility located at CERN on the PS Booster. It started operating in 1967 and was rebuilt twice with major upgrades in