Native Americans in the United States reached the West Coast in the 1770s, smallpox rapidly killed at least 30% of Northwest Coast Native Americans. For the next eighty to one hundred years, smallpox and other diseases devastated native populations in the region. Puget Sound area populations, once estimated as high as 37,000 people, were reduced to only 9,000 survivors by the time settlers arrived en masse in the mid-19th century. Smallpox epidemics in 1780–82 and 1837–38 brought devastation and drastic depopulation among the Plains Indians. By 1832, the federal government established a smallpox vaccination program for Native Americans ("The Indian Vaccination Act of 1832"). It was
Scottish Americans million Americans self-reported Scottish ancestry, 1.7% of the total US population. Another 4.3 million self-reported Scotch-Irish ancestry, for a total of 9.2 million Americans self-reporting some kind of Scottish descent. Self-reported numbers are regarded by demographers as massive under-counts, because Scottish ancestry is known to be disproportionately under-reported among the majority of mixed ancestry, and because areas where people reported "American" ancestry were the places where, historically, Scottish and Scotch-Irish Protestants settled in America (that is: along the North American coast, Appalachia, and the Southeastern United States). Scottish Americans descended from nineteenth-century Scottish emigrants tend to be concentrated in the