Scoliosis even when untreated, with mortality rates similar to the general population. Older beliefs that untreated idiopathic scoliosis necessarily progresses into severe (cardiopulmonary) disability by old age have been refuted by later studies. The many causes of scoliosis include spinal deformities, neuromuscular problems, and inherited diseases or conditions caused by the environment. An estimated 65% of scoliosis cases are idiopathic, about 15% are congenital, and about 10% are secondary to a neuromuscular disease. Idiopathic scoliosis represents a majority of cases, but its causes are largely unknown. Recent studies indicate potential heritability of the disorder. About 38% of variance in scoliosis risk
Neuromechanics of idiopathic scoliosis Besides, idiopathic scoliosis being more frequent in certain families, it is suspected to be transmitted via autosomal dominant inheritance. Estrogens could also play a crucial part in the progression of idiopathic scoliosis through their roles in bone formation, growth, maturation and turnover. Finally, collagen, intervertebral disc and muscle abnormalities have been suggested as the cause in idiopathic scoliosis, although these are perhaps results rather than causes. The patient’s age at presentation of scoliosis, the remaining growth, the menarche status and the magnitude of the curve are used to foresee the idiopathic scoliosis curve progression. However, the relative importance of each