Scoliosis and Spinal Disorders of cutting-edge spine research to further enhance effective collaboration among clinical spine specialists and scientists, and to ultimately improve patient outcomes based on an evidence-based spine care approach. The journal has had a remarkable history in providing thought-provoking and cutting-edge research and perspectives. Published by BioMed Central, "Scoliosis and Spinal Disorders" is the official journal of the Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) and is also affiliated with the International Research Society of Spinal Deformities (IRSSD), Hellenic Spine Society (HSS), Italian Scoliosis and Spine Study Group (GSS), Italian Physiotherapist Association (AIFI), Study in Multidisciplinary Pain Research (SIMPAR), Chinese
Scoliosis is due to genetic factors, and 62% is due to the environment. The genetics are likely complex, however, given the inconsistent inheritance and discordance among monozygotic twins. The specific genes that contribute to development of scoliosis have not been conclusively identified. At least one gene, "CHD7", has been associated with the idiopathic form of scoliosis. Several candidate gene studies have found associations between idiopathic scoliosis and genes mediating bone formation, bone metabolism, and connective tissue structure. Several genome-wide studies have identified a number of loci as significantly linked to idiopathic scoliosis. In 2006, idiopathic scoliosis was linked with three microsatellite