Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Pinky and the Brain the head. A few times in the series Pinky and Brain indeed pondered the same thing, though in one of these Pinky dismissed his idea as being too stupid. Just one time the answer was "Yes I am!", when Pinky's intelligence is elevated to match Brain's. In another episode, it turns out that what Pinky was pondering was that he and Brain never ponder the same thing, which turned out to be part of what Brain was pondering as well. In a short episode ("Pinky's POV") the spectator sees everything Pinky sees (including his imaginations) and hears his thoughts. His