Native Americans in the United States reached the West Coast in the 1770s, smallpox rapidly killed at least 30% of Northwest Coast Native Americans. For the next eighty to one hundred years, smallpox and other diseases devastated native populations in the region. Puget Sound area populations, once estimated as high as 37,000 people, were reduced to only 9,000 survivors by the time settlers arrived en masse in the mid-19th century. Smallpox epidemics in 1780–82 and 1837–38 brought devastation and drastic depopulation among the Plains Indians. By 1832, the federal government established a smallpox vaccination program for Native Americans ("The Indian Vaccination Act of 1832"). It was
Chinese Americans in Boston in four Chinese visitors coming to Boston for education. Acton had 2,041 Chinese Americans in 2010, a 151% increase from 2000 and the ninth largest Chinese population in Massachusetts. In 2000, Malden had 4,504 ethnic Chinese people, making up 57% of the city's Asian population. From 2000 to 2010 the Chinese population of Malden increased by about 50%. Malden Center is situated on the MBTA Orange Line which connects with Boston's Chinatown. The Chinese Progressive Association is located in Boston. The Boston Chinatown Neighborhood Center, Inc. (BCNC; ) serves Chinese Americans in the region. Its principal site is in the