Helium-3 of the airway tree, locate unventilated defects, measure the alveolar oxygen partial pressure, and measure the ventilation/perfusion ratio. This technique may be critical for the diagnosis and treatment management of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, and asthma. Production, sales and distribution of helium-3 in the United States are managed by the US Department of Energy (DOE) Isotope Program. Virtually all helium-3 used in industry today is produced from the radioactive decay of tritium. Tritium is a radioactive isotope of hydrogen and is typically produced by bombarding lithium-6 with neutrons in a nuclear
Hydrogen isotope biogeochemistry today's deuterium originated from this proton-proton fusion after sufficient cooling. Tritium, or hydrogen-3, with one proton and two neutrons, was produced by proton and neutron collisions in the early universe as well, but it has since radioactively decayed to helium-3. Modern tritium cannot be explained by big bang nucleosynthesis because of tritium's short half-life of 12.3 years. Today's tritium concentration is instead governed by nuclear reactions and cosmic rays. The radioactive beta decay of tritium to helium releases an electron and an antineutrino, with an average energy release of 18.6 MeV. It is important to note that this is classified