The Nexus Trilogy shoots a neuro toxin at Kade and Shu. Feng cuts Kades right arm off to prevent the spreading of the toxin. Shu is killed. Nexus 5 is spread around the world, despite the efforts of government forces. Warren Becker, the Enforcement Division Deputy Director at the ERD, commits suicide. Kade uses gecko genes to grow back his arm. Six months after the upload of the construction plan of the Nexus, a nano drug, which allows the brain to be programmed and networked, connecting human minds together, the world faces terrorism and massive abuse of the new technology. The Liberation Front,
The Nexus Trilogy agrees to work with the ERD and hand over Nexus 5. Kade and the group are sent to retrieve the Nexus 5 data, and on the way, they install a backdoor into the Nexus 5 operating system. Sam is required to have permanent integration with Nexus 5, despite her disagreement with Warren Becker, the Enforcement Division Deputy Director at the ERD. Kade and Sam, now with the pseudonym of Robyn Rodriguez, travel to Bangkok for a conference that Kade is invited to by Shu. Wats follows in hopes of setting Kade free and spreading Nexus 5 to the general public.