Electrical brain stimulation Electrical brain stimulation Electrical brain stimulation (EBS), also referred to as focal brain stimulation (FBS), is a form of electrotherapy and technique used in research and clinical neurobiology to stimulate a neuron or neural network in the brain through the direct or indirect excitation of its cell membrane by using an electric current. It is used for research or for therapeutical purposes. Electrical brain stimulation was first used in the first half of the 19th century by pioneering researchers such as Luigi Rolando (1773–1831) and Pierre Flourens (1794–1867), to study the brain localization of function, following the discovery by Italian
Nanoparticles for drug delivery to the brain that it can bind and undergo endocytosis. Another mechanism is "adsorption mediated transcytosis", where electrostatic interactions are involved in mediating nanoparticle crossing of the BBB. Cationic nanoparticles (including cationic liposomes) are of interest for this mechanism, because their positive charges assist binding on the brain's endothelial cells. Using TAT-peptides, a cell-penetrating peptide, to functionalize the surface of cationic nanoparticles can further improve drug transport into the brain. In contrast to the above mechanisms, a delivery with magnetic fields doesn't strongly depend on the biochemistry of the brain. In this case, nanoparticles are literally pulled across the BBB via application of