Helium-3 of the airway tree, locate unventilated defects, measure the alveolar oxygen partial pressure, and measure the ventilation/perfusion ratio. This technique may be critical for the diagnosis and treatment management of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, and asthma. Production, sales and distribution of helium-3 in the United States are managed by the US Department of Energy (DOE) Isotope Program. Virtually all helium-3 used in industry today is produced from the radioactive decay of tritium. Tritium is a radioactive isotope of hydrogen and is typically produced by bombarding lithium-6 with neutrons in a nuclear
Isotope separation first isotope separator was developed at the Copenhagen Cyclotron by Bohr and coworkers using the principle of electromagnetic separation. Today, there are many laboratories around the world that supply beams of radioactive ions for use. Arguably the principal Isotope Separator On Line (ISOL) is ISOLDE at CERN, which is a joint European facility spread across the Franco-Swiss border near the city of Geneva. This laboratory uses mainly proton spallation of uranium carbide targets to produce a wide range of radioactive fission fragments that are not found naturally on earth. During spallation (bombardment with high energy protons), a uranium carbide target