Helium-3 of the airway tree, locate unventilated defects, measure the alveolar oxygen partial pressure, and measure the ventilation/perfusion ratio. This technique may be critical for the diagnosis and treatment management of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, and asthma. Production, sales and distribution of helium-3 in the United States are managed by the US Department of Energy (DOE) Isotope Program. Virtually all helium-3 used in industry today is produced from the radioactive decay of tritium. Tritium is a radioactive isotope of hydrogen and is typically produced by bombarding lithium-6 with neutrons in a nuclear
Tritium in small quantities by some nuclear power plants. In January 2014 it was made public that a total of 875 TBq (2.45 g) of tritium are on the site of Fukushima Daiichi, and the amount of tritium contained in the contaminated water is increasing by approximately 230 TBq (0.64 g) per year. According to a report by Tepco ""Tritium could be separated theoretically, but there is no practical separation technology on an industrial scale"." Tritium's decay product helium-3 has a very large cross section for reacting with thermal neutrons, expelling a proton, hence it is rapidly converted back to tritium