Development of the nervous system in humans in the lower part. Neuronal migration is the method by which neurons travel from their origin or birthplace to their final position in the brain. There most common means of migration are radial and tangential migration. Neuronal precursor cells proliferate in the ventricular zone of the developing neocortex. The first postmitotic cells to migrate from the preplate which are destined to become Cajal-Retzius cells and subplate neurons. These cells do so by somal translocation. Neurons migrating with this mode of locomotion are bipolar and attach the leading edge of the process to the pia. The soma is then transported to
Nanoparticles for drug delivery to the brain drug. Bolaamphiphile nano-vesicles can cross the BBB, and they allow controlled release of the drug to target sites. Lipoplexes can also be formed from cationic liposomes and DNA solutions, to yield transfection agents. Cationic liposomes cross the BBB through adsorption mediated endocytosis followed by internalization in the endosomes of the endothelial cells. By transfection of endothelial cells through the use of lipoplexes, physical alterations in the cells could be made. These physical changes could potentially improve how some nanoparticle drug-carriers cross the BBB. Metal nanoparticles are promising as carriers for drug delivery to the brain. Common metals used for nanoparticle