Natural fiber exoskeletons of insects and arthropods. In shells and exoskeletons, the chitin fibers contribute to their hierarchical structure. In nature, pure chitin (100% acetylation) does not exist. It instead exists as a copolymer with chitin's deacetylated derivative, chitosan. When the acetylized composition of the copolymer is over 50% acetylated it is chitin. This copolymer of chitin and chitosan is a random or block copolymer. Chitosan is a deacetylated derivative of chitin. When the acetylized composition of the copolymer is below 50% it is chitosan. Chitosan is a semicrystalline “polymer of β-(1-4)-2-amino-2-deoxy-D-glucose”. One difference between chitin and chitosan is that chitosan is
Glucose-6-phosphate translocase potential for G6PT1 but systematically lack specificity in inhibition, rendering them poor drug candidates. Since the late 1990s, natural products have been increasingly studied as potent and specific inhibitors of G6PT1. Prominent examples of natural inhibitors include mumbaistatin and analogs, kodaistatin (harvested from extracts of "Asperigillus terreus") and chlorogenic acid. Other natural product inhibitors of G6PT1 are found in the fungi "Chaetomium carinthiacum", "Bauhinia magalandra" leaves, and streptomyces bacteria. 1) Excessive activity of G6PT1 may contribute to the development of diabetes. Diabetes mellitus type 2 is a disease characterized by chronically elevated blood glucose levels, even when fasting. The rapidly