Stephen J Smith Stephen J Smith Stephen J Smith is a Senior Investigator at the Allen Institute for Brain Science. Previously, Dr. Smith was Professor of Molecular and Cellular Physiology at the Stanford University School of Medicine. In 1990, Smith published an article in the journal "Science", which proposed that certain glial cells in the human brain known as astrocytes would be able to communicate through chemical signals, rather than electrical. By utilizing the neurotransmitter glutamate, he was able to show that these cells, which had once been perceived as inert tissue between neurons, in fact were actively communicating with the rest of
Intrinsically photosensitive retinal ganglion cells able to isomerize "all-trans-"retinal into "11-cis-"retinal when stimulated with light without help from additional cells. The two isoforms of melanopsin differ in their spectral sensitivity, for the "11-cis"-retinal isoform is more responsive to shorter wavelengths of light, while the "all-trans" isoform is more responsive to longer wavelengths of light. ipRGCs are both pre- and postsynaptic to dopaminergic amacrine cells (DA cells) via reciprocal synapses, with ipRGCs sending excitatory signals to the DA cells and the DA cells sending inhibitory signals to the ipRGCs. These inhibitory signals are mediated through GABA which is co-released from the DA cells along with dopamine.