Derailleur gears chain slack. Cage length determines the total capacity of the derailleur, that is the size difference between the largest and smallest chainrings, and the size difference between the largest and smallest sprockets on the cogset added together. A larger sum requires a longer cage length. Typical cross country mountain bikes with three front chainrings will use a long cage rear derailleur. A road bike with only two front chainrings and close ratio sprockets can operate with either a short or long cage derailleur, but will work better with a short cage. Manufacturer stated derailleur capacities are as follows: Shimano long
Mechanism of action inflammation. This mechanism of action is specific to aspirin, and is not constant for all nonsteroidal anti-inflammatory drugs (NSAIDs). Rather, aspirin is the only NSAID that irreversibly inhibits COX-1. Some drug mechanisms of action are still unknown. However, even though the mechanism of action of a certain drug is unknown, the drug still functions; it is just unknown or unclear how the drug interacts with receptors and produces its therapeutic effect. In some literature articles, the term mechanism of action and mode of action (MoA) are used interchangeably; typically referring to the way in which the drug interacts and produces