Tree from the cinchona tree ("Cinchona") and was for a long time the remedy of choice for the treatment of malaria. Aspirin was synthesised to replace the sodium salicylate derived from the bark of willow trees ("Salix") which had unpleasant side effects. The anti-cancer drug Paclitaxel is derived from taxol, a substance found in the bark of the Pacific yew ("Taxus brevifolia"). Other tree based drugs come from the paw-paw ("Carica papaya"), the cassia ("Cassia spp."), the cocoa tree ("Theobroma cacao"), the tree of life ("Camptotheca acuminata") and the downy birch ("Betula pubescens"). The papery bark of the white birch tree
Alnus cordata with a very long season in leaf, from April to December in the Northern Hemisphere; they are alternate, cordate (heart-shaped), rich glossy green, 5–12 cm long, with a finely serrated margin. The slender cylindrical male catkins are pendulous, reddish and up to 10 cm long; pollination is in early spring, before the leaves emerge. The female catkins are ovoid, when mature in autumn 2–3 cm long and 1.5–2 cm broad, dark green to brown, hard, woody, and superficially similar to some conifer cones. The small winged seeds disperse through the winter, leaving the old woody, blackish 'cones' on the tree