Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Pinky and the Brain mice are foiled by trying to speak "New York cabbie" and end up going in circles, the gag credit word was "anophelosis" defined as "morbid state due to extreme frustration". Another common element in nearly each episode is the following exchange (often referred to by the acronym "AYPWIP"): Brain: Pinky, are you pondering what I'm pondering?Pinky: I think so, Brain, but... Pinky's response ends with a non-sequitur such as, "we're already naked", "isn't a cucumber that small called a gherkin?" or "if they called them sad meals, kids wouldn't buy them." Brain would then become furious, often bashing Pinky over