Dead Brain Cells the name Dead Brain Cells among three suggestions by Leone, the others being "The Mental Pukes" and "The Retarded Assholes". Lowe had made commitments to his job and could not sing with the band anymore. Dakin decided he would sing and play bass at the same time. The band released two albums and toured twice in the United States. Their first album, "Dead Brain Cells", was released in 1987. It was followed by a concept album, "Universe", in 1989. Their song, "The Genesis Explosion", was featured in a Canadian television commercial for Microcell Telecommunications in 2005. The commercial depicts an
Nanoparticles for drug delivery to the brain constituents bind to nanoparticles, and then this complex binds to a low-density lipoprotein receptor (LDLR) in the BBB and allows transport to occur. The mechanism for the transport of polymer-based nanoparticles across the BBB has been characterized as receptor-mediated endocytosis by the brain capillary endothelial cells. Transcytosis then occurs to transport the nanoparticles across the tight junction of endothelial cells and into the brain. Surface coating nanoparticles with surfactants such as polysorbate 80 or poloxamer 188 was shown to increase uptake of the drug into the brain also. This mechanism also relies on certain receptors located on the luminal surface