Kinetic isotope effect both results are large enough to be indicative of weakening of the C-N bond in the transition state that would occur in a concerted process. Since kinetic isotope effects arise from differences in isotopic masses, the largest observable kinetic isotope effects are associated with isotopic substitutions of hydrogen with deuterium (100% increase in mass) or tritium (200% increase in mass). Kinetic isotope effects from isotopic mass ratios can be as large as 36.4 using muons. They have produced the lightest hydrogen atom, H (0.113 amu), in which an electron orbits around a positive muon (μ) "nucleus" that has a mass
Hydrogen isotope biogeochemistry as a relatively weak beta reaction, so the radioactivity cannot permeate skin. Tritium is thus only hazardous if directly ingested or inhaled. Protium is a spin 1/2 subatomic particle and is therefore a fermion. Other fermions include neutrons, electrons, and the radioactive isotope tritium. Fermions are governed by Pauli's exclusion principle, where no two particles can have the same quantum number. However, bosons like deuterium and photons, are not bound by exclusion and multiple particles can occupy the same energy state. This fundamental difference in H and H manifests in many physical properties. Integer spin particles like deuterium follow Bose-Einstein