Tritium deuterium, another isotope of hydrogen, by Ernest Rutherford, Mark Oliphant, and Paul Harteck. However, their experiment could not isolate tritium, which was later accomplished by Luis Alvarez and Robert Cornog, who also realized tritium's radioactivity. Willard F. Libby recognized that tritium could be used for radiometric dating of water and wine. Tritium Tritium ( or ; symbol ' or ', also known as hydrogen-3) is a radioactive isotope of hydrogen. The nucleus of tritium (sometimes called a triton) contains one proton and two neutrons, whereas the nucleus of protium (by far the most abundant hydrogen isotope) contains one proton and
Kinetic isotope effect now relatively routine. Moreover, several qualitative and semi-quantitative models allow rough estimates of deuterium isotope effects to be made without calculations, often providing enough information to rationalize experimental data or even support or refute different mechanistic possibilities. Starting materials containing deuterium are often commercially available, making the synthesis of isotopically enriched starting materials relatively straightforward. Also, due to the large relative difference in the mass of deuterium and protium and the attendant differences in vibrational frequencies, the magnitude of the isotope effect is larger than any other pair of isotopes except protium and tritium, allowing both primary and secondary isotope