Dead Brain Cells Dead Brain Cells Dead Brain Cells are a Canadian thrash metal band from the late 1980s. Called DBC for short, the band started in 1985 in Montreal as a small project named Final Chapter by guitar players Eddie Shahini and Gerry Ouellette, who put an ad in a magazine looking for a drummer. In 1986, former Vomit and the Zits singer Dave Javex Ray-O-Vac (David Leone) and former Unruled and Vomit and the Zits drummer Jeff Saint-Louis, joined with Shahini and Ouellette and guitar player Phil Dakin, who switched to bass. The project grew into a serious band which took
Nanoparticles for drug delivery to the brain stabilizing the nanoparticles and preventing the nanoparticles from aggregation. Metallic nanoparticles typically cross the BBB via transcytosis. Nanoparticle delivery through the BBB can be increased by introducing peptide conjugates to improve permeability to the central nervous system. For instance, recent studies have shown an improvement in gold nanoparticle delivery efficiency by conjugating a peptide that binds to the transferrin receptors expressed in brain endothelial cells. Also, solid lipid nanoparticles (SLNs) are lipid nanoparticles with a solid interior as shown in the diagram on the right. SLNs can be made by replacing the liquid lipid oil used in the emulsion process