Scoliosis polymorphisms in the "MATN1" gene (encoding for matrilin 1, cartilage matrix protein). Fifty-three single nucleotide polymorphism markers in the DNA that are significantly associated with adolescent idiopathic scoliosis were identified through a genome-wide association study. Adolescent idiopathic scoliosis has no clear causal agent, and is generally believed to be multifactorial. The prevalence of scoliosis is 1% to 2% among adolescents, but the likelihood of progression among adolescents with a Cobb angle less than 20° is about 10% to 20%. Congenital scoliosis can be attributed to a malformation of the spine during weeks three to six "in utero" due to a
Neuromechanics of idiopathic scoliosis scoliosis that appear after the age of 10 years, account for 89% of idiopathic scoliosis. From these statistics, it seems that individuals are at highest risk of developing idiopathic scoliosis during adolescence. Because scoliotic people have higher joint laxity compared to non-scoliotic people, they are drawn toward gymnastics but the practice of gymnastics for less than 20 hours training per week does not cause scoliosis. Based on populations that had more than 20 hours training per week, idiopathic scoliosis has been observed among 10% of tennis players, 16% of young swimmers and 24% in professional ballet companies. The exposure of