Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Journal of Physical and Chemical Reference Data "Journal Citation Reports", the journal has a 2017 impact factor of 3.510. Journal of Physical and Chemical Reference Data The Journal of Physical and Chemical Reference Data is a quarterly peer-reviewed scientific journal published by AIP Publishing on behalf of the National Institute of Standards and Technology. The objective of the journal is to provide critically evaluated physical and chemical property data, fully documented as to the original sources and the criteria used for evaluation, preferably with uncertainty analysis. The editors-in-chief are Donald R. Burgess, Jr, and Allan H. Harvey. The journal is abstracted and indexed in the Science Citation