Radial glial cell and OPCs can be generated from radial glial cells "in vitro", more evidence is yet needed to conclude whether this process also occurs in the developing brain. Recently, radial glia that exclusively generate upper-layer cortical neurons have also been discovered. Since upper cortical layers have expanded greatly in recent evolution, and are associated with higher-level information processing and thinking, radial glia have been implicated as important mediators of brain evolution. The best characterized and first widely accepted function of radial glia is their role as scaffolds for neuronal migration in the cerebral and cerebellar cortexes. This role can be easily
Decidual cells provide a rich source of nutrition for the developing embryo. Experimentally, human endometrial stromal cells can be decidualized in culture by using analogs of cAMP and progesterone. The cells will exhibit a decidualized phenotype and display upregulation of common decidualization markers such as prolactin and IGFBP1. Decidual cells Before the fertilized ovum reaches the uterus, the mucous membrane of the body of the uterus undergoes important changes and is then known as the decidua. The thickness and vascularity of the mucous membrane are greatly increased; its glands are elongated and open on its free surface by funnel-shaped orifices, while their