Heart rate node, where the faster pacemaker cells driving the self-generated rhythmic firing and responsible for the heart's autorhythmicity are located. For endurance athletes at the elite level, it is not unusual to have a resting heart rate between 33 and 50 bpm. The "maximum heart rate" (HR) is the highest heart rate an individual can achieve without severe problems through exercise stress, and generally decreases with age. Since HR varies by individual, the most accurate way of measuring any single person's HR is via a cardiac stress test. In this test, a person is subjected to controlled physiologic stress (generally by
Muscle contraction either excitatory (contractile) or inhibitory (relaxing). There are two types of cardiac muscle cells: autorhythmic and contractile. Autorhythmic cells do not contract, but instead set the pace of contraction for other cardiac muscle cells, which can be modulated by the autonomic nervous system. In contrast, contractile muscle cells (cardiomyocytes) constitute the majority of the heart muscle and are able to contract. Unlike skeletal muscle, excitation–contraction coupling in cardiac muscle is thought to depend primarily on a mechanism called calcium-induced calcium release. Though the proteins involved are similar, the L-type calcium channels and ryanodine receptors (RyRs) are not physically coupled. Instead,