Dead Brain Cells Dead Brain Cells Dead Brain Cells are a Canadian thrash metal band from the late 1980s. Called DBC for short, the band started in 1985 in Montreal as a small project named Final Chapter by guitar players Eddie Shahini and Gerry Ouellette, who put an ad in a magazine looking for a drummer. In 1986, former Vomit and the Zits singer Dave Javex Ray-O-Vac (David Leone) and former Unruled and Vomit and the Zits drummer Jeff Saint-Louis, joined with Shahini and Ouellette and guitar player Phil Dakin, who switched to bass. The project grew into a serious band which took
Nanoparticles for drug delivery to the brain that it can bind and undergo endocytosis. Another mechanism is "adsorption mediated transcytosis", where electrostatic interactions are involved in mediating nanoparticle crossing of the BBB. Cationic nanoparticles (including cationic liposomes) are of interest for this mechanism, because their positive charges assist binding on the brain's endothelial cells. Using TAT-peptides, a cell-penetrating peptide, to functionalize the surface of cationic nanoparticles can further improve drug transport into the brain. In contrast to the above mechanisms, a delivery with magnetic fields doesn't strongly depend on the biochemistry of the brain. In this case, nanoparticles are literally pulled across the BBB via application of