Big Bang nucleosynthesis amounts of the hydrogen isotope deuterium (H or D), the helium isotope helium-3 (He), and a very small amount of the lithium isotope lithium-7 (Li). In addition to these stable nuclei, two unstable or radioactive isotopes were also produced: the heavy hydrogen isotope tritium (H or T); and the beryllium isotope beryllium-7 (Be); but these unstable isotopes later decayed into He and Li, as above. Essentially all of the elements that are heavier than lithium were created much later, by stellar nucleosynthesis in evolving and exploding stars. There are several important characteristics of Big Bang nucleosynthesis (BBN): The key parameter
Kinetic isotope effect now relatively routine. Moreover, several qualitative and semi-quantitative models allow rough estimates of deuterium isotope effects to be made without calculations, often providing enough information to rationalize experimental data or even support or refute different mechanistic possibilities. Starting materials containing deuterium are often commercially available, making the synthesis of isotopically enriched starting materials relatively straightforward. Also, due to the large relative difference in the mass of deuterium and protium and the attendant differences in vibrational frequencies, the magnitude of the isotope effect is larger than any other pair of isotopes except protium and tritium, allowing both primary and secondary isotope