Glial scar hand, absence of the glial scar has been associated with impairments in the repair of the blood brain barrier. The glial scar is composed of several components briefly discussed below. Reactive astrocytes are the main cellular component of the glial scar. After injury, astrocytes undergo morphological changes, extend their processes, and increase synthesis of glial fibrillary acidic protein (GFAP). GFAP is an important intermediate filament protein that allows the astrocytes to begin synthesizing more cytoskeletal supportive structures and extend pseudopodia. Ultimately, the astrocytes form a dense web of their plasma membrane extensions that fills the empty space generated by the
Radial glial cell astrocytes, they have also been called "specialized astrocytes." Bergmann glia have multiple radial processes that extend across the molecular layer of the cerebral cortex and terminate at the pial surface as a bulbous endfoot. Bergmann glial cells assist with the migration of granule cells, guiding the small neurons from the external granular layer to the internal granular layer of the cerebral cortex along their extensive radial processes. Besides their role in early development of the cerebellum, Bergmann glia are also required for synaptic pruning. Following Purkinje cell death induced by CNS injury, Bergmann glia undergo extensive proliferative changes so as