Cardiovascular centre the cardiovascular centre and cause it to increase the rate of impulses sent to the sinoatrial node, or pacemaker, resulting in faster and stronger cardiac muscle contraction and thus increasing the heart rate. Cardiovascular centre The cardiovascular centre is a part of the human brain responsible for the regulation of the rate at which the heart beats through the nervous and endocrine systems. It is found in the medulla oblongata. Normally, the heart beats without nervous control, but in some situations (e.g., exercise, body trauma), the cardiovascular centre is responsible for altering the rate at which the heart beats. It
Heart failure with preserved ejection fraction and lower ejection fractions. Cardiac output is dependent on stroke volume and heart rate. A significant portion (55-77%) of HFpEF patients are unable to increase heart rate to compensate for increased output demand (as in the setting of exercise); this is termed chronotropic incompetence. Combined with the characteristic deficit in stroke volume observed in HFpEF patients, many individuals display poor exercise tolerance. Non-simultaneous contraction of the left and right ventricle, dyssychrony, is present in up to 58% of HFpEF patients. However, dyssynchrony is also common in HFrEF and its role in HFpEF in particular remains obscure. While therapies for dyssynchrony,