Human interactions with fungi the weather, and in the case of dry rot caused by "Serpula lacrymans", also of timbers in largely dry houses. Some wood-decay fungi such as the honey fungi, species of "Armillaria", are parasites of living trees, attacking their roots and eventually killing them, and continuing to decompose the wood when they are dead. Honey fungus is a serious horticultural pest, as it can spread from tree to tree by long strap-shaped rhizomorphs in the soil. Fungi are important crop pathogens, as they reproduce rapidly, affect a wide range of crops around the world, cause some 85% of plant diseases, and
Serpula lacrymans of 13805 genes. "S. lacrymans"' genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4, NPS7, NPS13-NPS15, NPS17, and NPS18), and two hybrids thereof (NPS6, NPS8, and NPS16). Additionally, the genome encodes for various putative adenylate-forming reductases (NPS5, NPS9-NPS12) (Eastwood et al., 2011). "NPS3" was overexpressed in E. coli and characterized as an atromentin/quinone synthetase that catalyzes the formation of atromentin, similar to GreA; InvA1,2 and 5; and AtrA from Suillus grevillei, Tapinella panuoides, Paxillus involutus, respectively. "NPS3" and its adjacent clustered aminotransferase gene ("AMT1") were also found to be up-regulated during co-incubation with bacteria (Tauber et al.,