Scoliosis polymorphisms in the "MATN1" gene (encoding for matrilin 1, cartilage matrix protein). Fifty-three single nucleotide polymorphism markers in the DNA that are significantly associated with adolescent idiopathic scoliosis were identified through a genome-wide association study. Adolescent idiopathic scoliosis has no clear causal agent, and is generally believed to be multifactorial. The prevalence of scoliosis is 1% to 2% among adolescents, but the likelihood of progression among adolescents with a Cobb angle less than 20° is about 10% to 20%. Congenital scoliosis can be attributed to a malformation of the spine during weeks three to six "in utero" due to a
Neuromechanics of idiopathic scoliosis Besides, idiopathic scoliosis being more frequent in certain families, it is suspected to be transmitted via autosomal dominant inheritance. Estrogens could also play a crucial part in the progression of idiopathic scoliosis through their roles in bone formation, growth, maturation and turnover. Finally, collagen, intervertebral disc and muscle abnormalities have been suggested as the cause in idiopathic scoliosis, although these are perhaps results rather than causes. The patient’s age at presentation of scoliosis, the remaining growth, the menarche status and the magnitude of the curve are used to foresee the idiopathic scoliosis curve progression. However, the relative importance of each