Derailleur gears designed and built in the late 19th century. One example is the Protean two-speed derailleur available on the Whippet safety bicycle. The French bicycle tourist, writer and cycling promoter Paul de Vivie (1853–1930), who wrote under the name "Vélocio", invented a two speed rear derailleur in 1905 which he used on forays into the Alps. Some early designs used rods to move the chain onto various gears. 1928 saw the introduction of the "Super Champion Gear" (or "Osgear") from the company founded by champion cyclist Oscar Egg, as well as the Vittoria Margherita; both employed chainstay mounted 'paddles' and single
Mechanism of action inflammation. This mechanism of action is specific to aspirin, and is not constant for all nonsteroidal anti-inflammatory drugs (NSAIDs). Rather, aspirin is the only NSAID that irreversibly inhibits COX-1. Some drug mechanisms of action are still unknown. However, even though the mechanism of action of a certain drug is unknown, the drug still functions; it is just unknown or unclear how the drug interacts with receptors and produces its therapeutic effect. In some literature articles, the term mechanism of action and mode of action (MoA) are used interchangeably; typically referring to the way in which the drug interacts and produces