Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Signals, Crane and Subway, Charters Towers railway station mechanical signals were controlled from signal cabins, which dealt with the traffic on a particular block of railway line. Signal cabins coordinated signals that indicated whether or not a section of track was clear of other traffic. Early signals were mechanical, while later signals were operated electrically. The most common form of mechanical signal was the semaphore signal. These consisted of a metal framed tower with one or more arms that could be inclined at different angles, with the arm at the horizontal signalling "danger", or do not proceed. Mechanical signals were usually worked by a wire cable running from