Non-celiac gluten sensitivity yet well understood. It was hypothesized that gluten, as occurs in celiac disease, is the cause of NCGS. Besides gluten, other components in wheat, rye, barley, and their derivatives, including amylasetrypsin inhibitors (ATIs) and FODMAPs, may cause symptoms. Some people may have a reaction to other proteins present in gluten-containing cereals that are able to inhibit amylase and trypsin (-α-amylase/trypsin inhibitors [ATIs]). ATIs are part of the plant's natural defense against insects and may cause toll-like receptor 4 (TLR4)-mediated intestinal inflammation in humans. These TLR4-stimulating activities of ATIs are limited to gluten-containing cereals (wheat, rye, barley, and derivatives) and may
Gluten-free, casein-free diet Gluten-free, casein-free diet Gluten-free casein-free diet (GFCF diet), also known as gluten-free dairy-free diet (GFDF diet), is a diet that does not include the proteins gluten (found most often in wheat, barley, and rye), and casein (found most often in milk and dairy products). Despite an absence of scientific evidence, there have been advocates for the use of this diet as a treatment for autism and related conditions. The majority of the available evidence does not support the use of this diet in the treatment of autism. The diet may have a negative effect on bone health, although there is