Chronic electrode implant Chronic electrode implant A chronic electrode implant is an electronic device implanted chronically (for a long period) into the brain or other electrically excitable tissue. It may record electrical impulses in the brain or may stimulate neurons with electrical impulses from an external source. The potential for neural interfacing technology to restore lost sensory or motor function is staggering; victims of paralysis due to peripheral nerve injury could achieve a full recovery by directly recording the output of their motor cortex, but the technology is immature and unreliable. There are numerous examples in the literature of intra-cortical electrode recording used
Nanoparticles for drug delivery to the brain drug. Bolaamphiphile nano-vesicles can cross the BBB, and they allow controlled release of the drug to target sites. Lipoplexes can also be formed from cationic liposomes and DNA solutions, to yield transfection agents. Cationic liposomes cross the BBB through adsorption mediated endocytosis followed by internalization in the endosomes of the endothelial cells. By transfection of endothelial cells through the use of lipoplexes, physical alterations in the cells could be made. These physical changes could potentially improve how some nanoparticle drug-carriers cross the BBB. Metal nanoparticles are promising as carriers for drug delivery to the brain. Common metals used for nanoparticle