Cardiovascular centre the cardiovascular centre and cause it to increase the rate of impulses sent to the sinoatrial node, or pacemaker, resulting in faster and stronger cardiac muscle contraction and thus increasing the heart rate. Cardiovascular centre The cardiovascular centre is a part of the human brain responsible for the regulation of the rate at which the heart beats through the nervous and endocrine systems. It is found in the medulla oblongata. Normally, the heart beats without nervous control, but in some situations (e.g., exercise, body trauma), the cardiovascular centre is responsible for altering the rate at which the heart beats. It
Cardiac glycoside changes to heart chronotropic activity, resulting in multiple kinds of dysrhythmia and potentially fatal ventricular tachycardia. These dysrhythmias are an effect of an influx of sodium and decrease of resting membrane potential threshold in cardiac muscle cells. When taken beyond a narrow dosage range specific to each particular cardiac glycoside, these compounds can rapidly become dangerous. In sum, they interfere with fundamental processes that regulate membrane potential they are toxic to the heart, the brain, and the gut, at doses that are not difficult to reach. (In the heart, the most common negative effect is Premature ventricular contraction.) Cardiac glycoside