Serpula lacrymans dry rot was at least 150 million pounds per annum. Three variants/strains of S. lacrymans have been sequenced by the Joint Genome Institute (JGI) and its collaborators, and sequence data is available via their MycoCosm portal. One genome is from Serpula lacrymans S7.9 (v2.0). The genome assembly is 42.73 Mbp, with a predicted number of 12789 genes. The second genome is from Serpula lacrymans S7.3 (v2.0). The genome assembly is 47 Mbp, with a predicted number of 14495 genes. The third genome is from Serpula lacrymans var shastensis SHA21-2 (v1.0). The genome assembly is 45.98 Mbp, with a predicted number
Serpula lacrymans of 13805 genes. "S. lacrymans"' genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4, NPS7, NPS13-NPS15, NPS17, and NPS18), and two hybrids thereof (NPS6, NPS8, and NPS16). Additionally, the genome encodes for various putative adenylate-forming reductases (NPS5, NPS9-NPS12) (Eastwood et al., 2011). "NPS3" was overexpressed in E. coli and characterized as an atromentin/quinone synthetase that catalyzes the formation of atromentin, similar to GreA; InvA1,2 and 5; and AtrA from Suillus grevillei, Tapinella panuoides, Paxillus involutus, respectively. "NPS3" and its adjacent clustered aminotransferase gene ("AMT1") were also found to be up-regulated during co-incubation with bacteria (Tauber et al.,