Cardiovascular centre the cardiovascular centre and cause it to increase the rate of impulses sent to the sinoatrial node, or pacemaker, resulting in faster and stronger cardiac muscle contraction and thus increasing the heart rate. Cardiovascular centre The cardiovascular centre is a part of the human brain responsible for the regulation of the rate at which the heart beats through the nervous and endocrine systems. It is found in the medulla oblongata. Normally, the heart beats without nervous control, but in some situations (e.g., exercise, body trauma), the cardiovascular centre is responsible for altering the rate at which the heart beats. It
Cardiac contractility modulation the electrical non-excitatory state of the cardiac muscle cells (the absolute refractory period) cause an increase in myocyte calcium in the cytosol during systole. This increases the muscle contraction strength. Additionally, within minutes, cell metabolism and gene expression, which are typically abnormal in heart failure, improve towards their normal state. This beneficial effect occurs initially only in the area adjacent to the electrodes, but with time also spreads to remote areas of the cardiac muscle. Cardiac contractility modulation therefore restores the structure and function of damaged cells back towards their normal state. In some cases, disease-related changes in the ventricular