Gluten immunochemistry in foods that have added gluten, such as wheat bread, food pastes. The major gluten proteins that are involved in coeliac disease are the α-gliadin isoforms. Alpha gliadin is composed of repeated motifs that, when digested, can be presented by HLA-DQ molecules. DQ2.5 recognizes several motifs in gluten proteins, and therefore HLA-DQ can recognize many motifs on each gliadin (see Understanding DQ haplotypes and DQ isoforms on the right) However, numbers of different proteins from the grass tribe Triticeae have been found to carry motifs presented by HLA DQ2.5 and DQ8. Wheat has a large number of these proteins because
Wheat allergy comes from the progenitor species "Aegilops speltoides". This indicates that nascent mutations on the B genome of wheat are from a small number of cultivated Triticeae species. Recent study of WDEIA shows that both aspirin and exercise increase the presence of gliadin in the blood stream and the chronic induced response may extend to NSAIDs, MSG, Benzoate and other synthetic chemical food additives. Baker's allergy has a ω-gliadin component and thioredoxin hB component. In addition, a gluten-extrinsic allergen has been identified as aspergillus amylase, added to flour to increase its baking properties. Contact sensitivity, atopic dermatitis, eczema, and urticaria appear