Chronic electrode implant Chronic electrode implant A chronic electrode implant is an electronic device implanted chronically (for a long period) into the brain or other electrically excitable tissue. It may record electrical impulses in the brain or may stimulate neurons with electrical impulses from an external source. The potential for neural interfacing technology to restore lost sensory or motor function is staggering; victims of paralysis due to peripheral nerve injury could achieve a full recovery by directly recording the output of their motor cortex, but the technology is immature and unreliable. There are numerous examples in the literature of intra-cortical electrode recording used
Nanoparticles for drug delivery to the brain constituents bind to nanoparticles, and then this complex binds to a low-density lipoprotein receptor (LDLR) in the BBB and allows transport to occur. The mechanism for the transport of polymer-based nanoparticles across the BBB has been characterized as receptor-mediated endocytosis by the brain capillary endothelial cells. Transcytosis then occurs to transport the nanoparticles across the tight junction of endothelial cells and into the brain. Surface coating nanoparticles with surfactants such as polysorbate 80 or poloxamer 188 was shown to increase uptake of the drug into the brain also. This mechanism also relies on certain receptors located on the luminal surface