Sensory maps and brain development the midbrain auditory nucleus had receptive fields independent of nature and intensity of the sound. Roger Sperry proposed a chemical gradient model for eye rotation and for neuronal wiring diagram. Retinal neurons and target cells had identification tags in the form of chemical gradients so that the projection of neurons would be orderly. For a topographic map of the visual world, the map first forms during neural development via molecular signals, such as chemospecific matching between molecular gradients. The molecular basis of sensory maps and brain development is a field that is being actively explored. The most recent work has
Nanoparticles for drug delivery to the brain constituents bind to nanoparticles, and then this complex binds to a low-density lipoprotein receptor (LDLR) in the BBB and allows transport to occur. The mechanism for the transport of polymer-based nanoparticles across the BBB has been characterized as receptor-mediated endocytosis by the brain capillary endothelial cells. Transcytosis then occurs to transport the nanoparticles across the tight junction of endothelial cells and into the brain. Surface coating nanoparticles with surfactants such as polysorbate 80 or poloxamer 188 was shown to increase uptake of the drug into the brain also. This mechanism also relies on certain receptors located on the luminal surface