Sensory maps and brain development the midbrain auditory nucleus had receptive fields independent of nature and intensity of the sound. Roger Sperry proposed a chemical gradient model for eye rotation and for neuronal wiring diagram. Retinal neurons and target cells had identification tags in the form of chemical gradients so that the projection of neurons would be orderly. For a topographic map of the visual world, the map first forms during neural development via molecular signals, such as chemospecific matching between molecular gradients. The molecular basis of sensory maps and brain development is a field that is being actively explored. The most recent work has
Induced stem cells applied to a large number of cells to produce stem cells for medical purposes on an industrial scale. Cells involved in the reprogramming process change morphologically as the process proceeds. This results in physical difference in adhesive forces among cells. Substantial differences in 'adhesive signature' between pluripotent stem cells, partially reprogrammed cells, differentiated progeny and somatic cells allowed to develop separation process for isolation of pluripotent stem cells in microfluidic devices, which is: Stem cells possess mechanical memory (they remember past physical signals) – with the Hippo signaling pathway factors: Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ)