Scoliosis an adolescent's growth spurt and is more often diagnosed in females than males. Scoliosis associated with known syndromes is often subclassified as "syndromic scoliosis". Scoliosis can be associated with amniotic band syndrome, Arnold–Chiari malformation, Charcot–Marie–Tooth disease, cerebral palsy, congenital diaphragmatic hernia, connective tissue disorders, muscular dystrophy, familial dysautonomia, CHARGE syndrome, Ehlers–Danlos syndrome (hyperflexibility, "floppy baby" syndrome, and other variants of the condition), fragile X syndrome, Friedreich's ataxia, hemihypertrophy, Loeys-Dietz syndrome, Marfan's syndrome, nail–patella syndrome, neurofibromatosis, osteogenesis imperfecta, Prader–Willi syndrome, proteus syndrome, spina bifida, spinal muscular atrophy and syringomyelia. Another form of secondary scoliosis is the degenerative scoliosis which develops later
Neuromechanics of idiopathic scoliosis the body to high repetitive mechanical constraints may influence the occurrence of idiopathic scoliosis. Cobb angle is a common measure to classify scoliosis. The greater the angle, the more serious is the disease but the smaller is the number of patients. One to three out of every hundred people have idiopathic scoliosis curves greater than 10° with an equal proportion of boys and girls. One to three out of every thousand people have idiopathic scoliosis curves greater than 30° with a ratio of eight girls for every one boy. Scoliosis is also classified according to the region(s) they affect. The