Mechanism of anoxic depolarization in the brain intracellular Na and Ca ions, and extracellular glutamate and aspartate. Glutamate and aspartate are normally present as the brain's primary excitatory neurotransmitters, but high concentrations activate a number of downstream apoptotic and necrotic pathways. This results in neuronal dysfunction and death. Neurons function in the central nervous system by generating signals from synapses, and this only works in the proper chemical environment. An electrical signal is mediated by the sodium channels and leaky potassium channels in which intracellular K ion concentration is higher than its corresponding extracellular concentration, whereas extracellular concentrations of Na, Ca, and Cl ions are higher than
Cross-industry standard process for data mining Cross-industry standard process for data mining Cross-industry standard process for data mining, known as CRISP-DM, is an open standard process model that describes common approaches used by data mining experts. It is the most widely-used analytics model. In 2015, IBM corporation released a new methodology called "Analytics Solutions Unified Method for Data Mining/Predictive Analytics" (also known as ASUM-DM) which refines and extends CRISP-DM. CRISP-DM was conceived in 1996 and became a European Union project under the ESPRIT funding initiative in 1997. The project was led by five companies: Integral Solutions Ltd (ISL), Teradata, Daimler AG, NCR Corporation and OHRA, an