Intercalated cells of the amygdala mPFC) in both primates and rodents, which may explain cortical control over emotional regulation processes such as extinction. Intercalated cells of the amygdala The intercalated (ITC) cells of the amygdala are a group of GABAergic neurons situated between the basolateral and central nuclei of the amygdala that are important for inhibitory control over the amygdala. ITC cells are thought to play a role as the 'off switch' for the amygdala, inhibiting the amygdala's central nucleus output neurons and its basolateral nucleus neurons. Some researchers speculate that ITC cells, via their extensive local inhibition within the amygdala, could serve as a
Nanoparticles for drug delivery to the brain drug. Bolaamphiphile nano-vesicles can cross the BBB, and they allow controlled release of the drug to target sites. Lipoplexes can also be formed from cationic liposomes and DNA solutions, to yield transfection agents. Cationic liposomes cross the BBB through adsorption mediated endocytosis followed by internalization in the endosomes of the endothelial cells. By transfection of endothelial cells through the use of lipoplexes, physical alterations in the cells could be made. These physical changes could potentially improve how some nanoparticle drug-carriers cross the BBB. Metal nanoparticles are promising as carriers for drug delivery to the brain. Common metals used for nanoparticle