Helium-3 of the airway tree, locate unventilated defects, measure the alveolar oxygen partial pressure, and measure the ventilation/perfusion ratio. This technique may be critical for the diagnosis and treatment management of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, and asthma. Production, sales and distribution of helium-3 in the United States are managed by the US Department of Energy (DOE) Isotope Program. Virtually all helium-3 used in industry today is produced from the radioactive decay of tritium. Tritium is a radioactive isotope of hydrogen and is typically produced by bombarding lithium-6 with neutrons in a nuclear
Isotope geochemistry usually is given as a multiple of the present atmospheric ratio (Ra). Common values for R/Ra: He/He isotope chemistry is being used to date groundwaters, estimate groundwater flow rates, track water pollution, and provide insights into hydrothermal processes, igneous geology and ore genesis. U-series isotopes are unique amongst radiogenic isotopes because, being in the U-series decay chains, they are both radiogenic and radioactive. Because their abundances are normally quoted as activity ratios rather than atomic ratios, they are best considered separately from the other radiogenic isotope systems. Uranium is well mixed in the ocean, and its decay produces Pa and