Glial cell line-derived neurotrophic factor and is the first member of the GDNF family of ligands (GFL) found. Glial cell line-derived neurotrophic factor has been shown to interact with GFRA2 and GDNF family receptor alpha 1. GDNF has regenerative properties for brain cells and showed potential as treatment for Parkinson's disease - monkeys with an induced form of Parkinson's disease showed less trembling when treated with the drug, and neuronal fibres grew in part of the human brain exposed to the drug. However progress to a treatment is hampered by the problem of delivering the drug to brain cells through the blood-brain barrier in human.
Nasal glial heterotopia there is a large amount of associated fibrosis. The lesions are usually <2 cm in greatest dimension. A trichrome stain will highlight the dual components well, with the glial tissue staining red, while the background fibrosis stains a bright blue. The glial tissue is highlighted with S100 protein and with glial fibrillary acidic protein, although the latter is much more sensitive for glial tissue. The most common missed lesion is within the nasal cavity, where a fibrosed nasal polyp may be considered. However, it does not have glial tissue. Further, a polyp usually has mucoserous glands. The lesion is frequently