Radial glial cell and OPCs can be generated from radial glial cells "in vitro", more evidence is yet needed to conclude whether this process also occurs in the developing brain. Recently, radial glia that exclusively generate upper-layer cortical neurons have also been discovered. Since upper cortical layers have expanded greatly in recent evolution, and are associated with higher-level information processing and thinking, radial glia have been implicated as important mediators of brain evolution. The best characterized and first widely accepted function of radial glia is their role as scaffolds for neuronal migration in the cerebral and cerebellar cortexes. This role can be easily
Perisynaptic schwann cells cells of which Perisynaptic Schwann cells are a subset. Neural crest cells are found in the dorsal neural tube from which nerves and glia alike grow and Neural crest cells are the precursors to many various tissue types including enteric neurons and glia. Schwann cell precursors (a first derivative of Neural crest cells) are present as the nerve axon grows from the dorsal neural tube, but it has been shown that these glial precursors are not essential to axonal growth. The transition from neural crest cells to Schwann cell precursors is characterized by Sox10 and generally occurs around embryonic day