Glial fibrillary acidic protein rodent brain. These isoforms include GFAP kappa, GFAP +1 and the currently best researched GFAP delta. GFAP delta appears to be linked with neural stem cells (NSCs) and may be involved in migration. GFAP+1 is an antibody which labels two isoforms. Although GFAP+1 positive astrocytes are supposedly not reactive astrocytes, they have a wide variety of morphologies including processes of up to 0.95mm (seen in the human brain). The expression of GFAP+1 positive astrocytes is linked with old age and the onset of AD pathology. Glial fibrillary acidic protein Glial fibrillary acidic protein (GFAP) is a protein that is encoded
Radial glial cell astrocytes, they have also been called "specialized astrocytes." Bergmann glia have multiple radial processes that extend across the molecular layer of the cerebral cortex and terminate at the pial surface as a bulbous endfoot. Bergmann glial cells assist with the migration of granule cells, guiding the small neurons from the external granular layer to the internal granular layer of the cerebral cortex along their extensive radial processes. Besides their role in early development of the cerebellum, Bergmann glia are also required for synaptic pruning. Following Purkinje cell death induced by CNS injury, Bergmann glia undergo extensive proliferative changes so as