Cell signaling of adjacent cells. In cardiac muscle, gap junctions between adjacent cells allows for action potential propagation from the cardiac pacemaker region of the heart to spread and coordinately cause contraction of the heart. The notch signaling mechanism is an example of juxtacrine signaling (also known as contact-dependent signaling) in which two adjacent cells must make physical contact in order to communicate. This requirement for direct contact allows for very precise control of cell differentiation during embryonic development. In the worm "Caenorhabditis elegans", two cells of the developing gonad each have an equal chance of terminally differentiating or becoming a uterine
"What Is This Heart?" of 69, based on 32 reviews, which indicates "generally favorable reviews". Ian Cohen of Pitchfork Media gave a very positive review of the album stating, ""What Is This Heart?" makes you initially susceptible and vulnerable, and that’s risky when modern discourse seeks metaphorical blood, allowing people to disclose more than ever without actually revealing anything. So make no mistake, the title of this album is a challenge as well, as How to Dress Well’s modern masterpiece is conducted with the most eternal transparency—Krell asks “what is this heart” and lets you look right into his own." "What Is This Heart?"