Kinetic isotope effect effects, while "k"/"k" ~ 1.15-1.3 are typical for β secondary kinetic isotope effect. For reactants containing several isotopically-substituted β-hydrogen atoms, the observed isotope effect is often the result of several H/D's at the β position acting in concert. In these cases, the effect of each isotopically-labeled atom is multiplicative, and cases where "k"/"k" > 2 are not uncommon. The following simple expressions relating deuterium and tritium kinetic isotope effects, which are also known as the Swain equation (or the Swain-Schaad-Stivers equations), can be derived from the general expression given above using some simplifications: i.e., In deriving these expressions, the reasonable
On-Line Isotope Mass Separator On-Line Isotope Mass Separator The On-Line Isotope Mass Separator, also known as the ISOLDE Radioactive Ion Beam Facility, is a facility located at CERN on the PS Booster. It started operating in 1967 and was rebuilt twice with major upgrades in 1974 and 1992. ISOLDE (Isotope Separator On Line DEtector) is dedicated to producing radioactive nuclei for a number of applications covering nuclear, atomic, molecular and solid-state physics, but also biophysics and astrophysics. The large variety of available species allows the systematic study of atomic and nuclear properties and exotic decays far from the line of stability. As of 2006,