Helium-3 of the airway tree, locate unventilated defects, measure the alveolar oxygen partial pressure, and measure the ventilation/perfusion ratio. This technique may be critical for the diagnosis and treatment management of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, and asthma. Production, sales and distribution of helium-3 in the United States are managed by the US Department of Energy (DOE) Isotope Program. Virtually all helium-3 used in industry today is produced from the radioactive decay of tritium. Tritium is a radioactive isotope of hydrogen and is typically produced by bombarding lithium-6 with neutrons in a nuclear
Hydrogen isotope biogeochemistry as a relatively weak beta reaction, so the radioactivity cannot permeate skin. Tritium is thus only hazardous if directly ingested or inhaled. Protium is a spin 1/2 subatomic particle and is therefore a fermion. Other fermions include neutrons, electrons, and the radioactive isotope tritium. Fermions are governed by Pauli's exclusion principle, where no two particles can have the same quantum number. However, bosons like deuterium and photons, are not bound by exclusion and multiple particles can occupy the same energy state. This fundamental difference in H and H manifests in many physical properties. Integer spin particles like deuterium follow Bose-Einstein