Kinetic Isotope Effects of RuBisCO carbon, oxygen, and/or hydrogen, though currently only a significant isotope effect is seen for carbon isotope substitution. Isotopes are atoms that have the same number of protons but varying numbers of neutrons. "Lighter" isotopes (like the stable Carbon-12 isotope) have a smaller overall mass, and "heavier" isotopes (like the stable Carbon-13 isotope or radioactive Carbon-14 isotope) have a larger overall mass. Stable isotope geochemistry is concerned with how varying chemical and physical processes preferentially enrich or deplete stable isotopes. Enzymes like RuBisCO cause isotopic fractionation because molecules containing lighter isotopes have higher zero-point energies (ZPE), the lowest possible quantum energy
High-level radioactive waste management involving permanent storage, disposal or transformation of the waste into a non-toxic form. Radioactive decay follows the half-life rule, which means that the rate of decay is inversely proportional to the duration of decay. In other words, the radiation from a long-lived isotope like iodine-129 will be much less intense than that of short-lived isotope like iodine-131. Governments around the world are considering a range of waste management and disposal options, usually involving deep-geologic placement, although there has been limited progress toward implementing long-term waste management solutions. This is partly because the timeframes in question when dealing with radioactive waste