Metastability in the brain for a continuum of integration. One theory used to integrate the dynamic core with conscious thought involves a developing concept known as neural Darwinism. In this model, metastable interactions in the thalamocortical region cause a process of selectionism through re-entry (a phenomenon describing the overall reciprocity and interactivity between signals in distant parts of the brain through coupled signal latency). Neuronal selectivity involves mechanochemical events that take place pre- and post-natally whereby neuronal connections are influenced by environmental experiences. The modification of synaptic signals as it relates to the dynamic core provides further explanation for the DCH. Despite growing evidence
Nanoparticles for drug delivery to the brain drug. Bolaamphiphile nano-vesicles can cross the BBB, and they allow controlled release of the drug to target sites. Lipoplexes can also be formed from cationic liposomes and DNA solutions, to yield transfection agents. Cationic liposomes cross the BBB through adsorption mediated endocytosis followed by internalization in the endosomes of the endothelial cells. By transfection of endothelial cells through the use of lipoplexes, physical alterations in the cells could be made. These physical changes could potentially improve how some nanoparticle drug-carriers cross the BBB. Metal nanoparticles are promising as carriers for drug delivery to the brain. Common metals used for nanoparticle