The Nexus Trilogy a treadmill in Kyoto, Japan. Later work done by Phillip Kennedy and colleagues built the first intracortical brain–computer interface by implanting neurotrophic-cone electrodes into one man, Johnny Ray, a stroke victim unable to move muscles below his face. With the connection made, the electrodes can record the electrical impulses that travel across neurons when thinking occurs. Those signals are transferred to a transmitter embedded beneath the scalp. Amplified 1,000 times, the signals go to a computer, which translates them into cursor movement, allowing him the ability to communicate simply by thinking. Other research has seen success with sensory data, including
Nanoparticles for drug delivery to the brain drug. Bolaamphiphile nano-vesicles can cross the BBB, and they allow controlled release of the drug to target sites. Lipoplexes can also be formed from cationic liposomes and DNA solutions, to yield transfection agents. Cationic liposomes cross the BBB through adsorption mediated endocytosis followed by internalization in the endosomes of the endothelial cells. By transfection of endothelial cells through the use of lipoplexes, physical alterations in the cells could be made. These physical changes could potentially improve how some nanoparticle drug-carriers cross the BBB. Metal nanoparticles are promising as carriers for drug delivery to the brain. Common metals used for nanoparticle