Isotopes of hydrogen used for deuterium and tritium. The IUPAC accepts the D and T symbols, but recommends instead using standard isotopic symbols (H and H) to avoid confusion in the alphabetic sorting of chemical formulas. The ordinary isotope of hydrogen, with no neutrons, is sometimes called "protium". (During the early study of radioactivity, some other heavy radioactive isotopes were given names, H (atomic mass u) is the most common hydrogen isotope with an abundance of more than 99.98%. Because the nucleus of this isotope consists of only a single proton, it is given the formal name "protium". The proton has never been
Kinetic isotope effect now relatively routine. Moreover, several qualitative and semi-quantitative models allow rough estimates of deuterium isotope effects to be made without calculations, often providing enough information to rationalize experimental data or even support or refute different mechanistic possibilities. Starting materials containing deuterium are often commercially available, making the synthesis of isotopically enriched starting materials relatively straightforward. Also, due to the large relative difference in the mass of deuterium and protium and the attendant differences in vibrational frequencies, the magnitude of the isotope effect is larger than any other pair of isotopes except protium and tritium, allowing both primary and secondary isotope