Honey bee as apitoxin, carries several active components, the most abundant of which is melittin, and the most biologically active are enzymes, particularly phospholipase A2. Bee venom is under laboratory and clinical research for its potential properties and uses in reducing risks for adverse events from bee venom therapy, rheumatoid arthritis, and use as an immunotherapy for protection against allergies from insect stings. Bee venom products are marketed in many countries, but, as of 2018, there are no approved clinical uses for these products which carry various warnings for potential allergic reactions. With an increased number of honey bees in a specific
Venom Snake of "Venom Snake", which is the name that was used in most of the promotional imagery and merchandising since E3 2014. Although the final game bills him as "Punished 'Venom' Snake" in the opening sequence of every mission, the codename "Punished Snake" is never spoken by anyone, while the name "Venom Snake" is only mentioned once in the actual script - otherwise the character is simply referred to as "Snake" or "Big Boss". During the prologue sequence of the game, the player character is briefly given the name by the medical staff protecting him in Cyprus, while Big Boss (whose