Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Vickers Venom "3" on the fuselages sides, the Venom was painted a cream colour for exhibition purposes. The need to concentrate on the Spitfire led to the scrapping of the sole Venom prototype in 1939, after a crash in testing. Vickers Venom The Vickers Type 279 Venom was a low-wing monoplane single-seat, single-engined, eight-gun fighter, powered by a radial engine. It was fast and manoeuvrable but its engine lacked the power and development potential of its Merlin-powered competitors. Only one was built. The Vickers Venom was designed to meet Air Ministry specification F.5/34 which called for a single-seat eight-gun aircraft with the