Ionizing radiation a cancer per dose model to assert that such activities cause several hundred cases of cancer per year, an application of the widely accepted Linear no-threshold model (LNT). The International Commission on Radiological Protection recommends limiting artificial irradiation to the public to an average of 1 mSv (0.001 Sv) of effective dose per year, not including medical and occupational exposures. In a nuclear war, gamma rays from both the initial weapon explosion and fallout would be the sources of radiation exposure. Massive particles are a concern for astronauts outside the earth's magnetic field who would receive solar particles from solar
Biological effects of radiation on the epigenome and structure and therefore effectively destabilizes the cell. Ionizing radiation causes the cell to generate increased ROS and the increase of this species damages biological macromolecules. In order to compensate for this increased radical species, cells adapt to IR induced oxidative effects by modifying the mechanisms of epigenetic gene regulation. There are 4 epigenetic modifications that can take place: ROS generated by ionizing radiation chemically modify histones which can cause a change in transcription. Oxidation of cellular lipid components result in an electrophilic molecule formation. The electrophilic molecule binds to the lysine residues of histones causing a ketoamide adduct formation.