Apamin Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino acids are involved in the binding of apamin to the Ca-activated K channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the
Platypus venom characteristic uniquely, the platypus simply inherited its venom from its distant ancestors. Rather than being a unique outlier, the platypus is the last demonstration of what was once a common mammalian characteristic, and it can be used as a model for non-therian mammals and their venom delivery and properties. The venom is produced in the crural glands of the male, which are kidney-shaped alveolar glands located in the upper thigh connected by a thin-walled duct to a calcaneus spur, or calcar, on each hind limb. Female platypuses, in common with echidnas, have rudimentary spur buds that do not develop (dropping