Tempranillo the Spanish Conquistadors in the 17th century, as certain Criolla varieties in Argentina have a closer genetic relationship to Tempranillo than to a small handful of other European varieties against which the Criolla varieties were tested. Despite its apparent fragility, Tempranillo travelled widely during the 20th century and, following much trial and error, has become established throughout the world. In 1905, Frederic Bioletti brought Tempranillo to California where it received a cool reception not only due to the encroaching era of Prohibition, but also because of the grape's dislike of hot, dry climates. It was much later, during the 1980s,
Petite mutation petite negative mutants. Potentially, these yeasts have a different inheritance system in place for their mitchondrial genome than "S. cerevisiae" does. The frequency at which "S. castellii" spontaneously produces petites is similar to that of "S. cerevisiae", with the mitochondrial DNA of those petites being highly altered via deletion and rearrangement. Suppressive petites of "S. cerevisiae" are the most commonly observed spontaneously created mutants, whereas in "S. castellii," the most commonly observed spontaneous mutant is the neutral petite, further leading to speculation that the transference of this mutation differs between species. Petite mutation petite (ρ–) is a mutant first discovered