Ewan McGregor Collar" (1993). Not long afterwards, he starred in the BBC adaptation of "Scarlet and Black" (also 1993) with a young Rachel Weisz, and made his film debut in Bill Forsyth's "Being Human" (1994). For his role in the thriller "Shallow Grave" (also 1994), he won an Empire Award. The film was his first collaboration with director Danny Boyle. His international breakthrough followed with the role of heroin addict Mark Renton in Boyle's "Trainspotting" (1996), an adaptation of Irvine Welsh's novel of the same name. McGregor played the male romantic lead role in the British film "Little Voice" (1998). He was
Heroin used and faster the route of administration used, the higher potential risk for psychological addiction. Large doses of heroin can cause fatal respiratory depression, and the drug has been used for suicide or as a murder weapon. The serial killer Harold Shipman used diamorphine on his victims, and the subsequent Shipman Inquiry led to a tightening of the regulations surrounding the storage, prescribing and destruction of controlled drugs in the UK. John Bodkin Adams is also known to have used heroin as a murder weapon. Because significant tolerance to respiratory depression develops quickly with continued use and is lost just