Yellow fever seems to play a role in single, sudden breakouts of the disease. Three epidemiologically different infectious cycles occur, in which the virus is transmitted from mosquitoes to humans or other primates. In the "urban cycle", only the yellow fever mosquito "A. aegypti" is involved. It is well adapted to urban areas, and can also transmit other diseases, including Zika fever, dengue fever, and chikungunya. The urban cycle is responsible for the major outbreaks of yellow fever that occur in Africa. Except for an outbreak in Bolivia in 1999, this urban cycle no longer exists in South America. Besides the urban
1793 Philadelphia yellow fever epidemic atmosphere that might last 50 years and make deadly epidemics almost certain. Yellow fever epidemics became seen as a national crisis. When in 1855 a French doctor published an 813-page history of yellow fever in Philadelphia, covering outbreaks from 1699 to 1854, he devoted only a few pages to the 1793 epidemic. General 20th-century US histories, such as the 10-volume "Great Epochs in American History," published in 1912, used short excerpts from Carey's account. The first history of the epidemic to draw on more primary sources was J. H. Powell's "Bring Out Your Dead" (1949), but he did not use