Yellow fever by their newly discovered canals, which were perhaps made to absorb carbon and prevent the disease. In 1848, Josiah C. Nott suggested that yellow fever was spread by insects such as moths or mosquitoes, basing his ideas on the pattern of transmission of the disease. Carlos Finlay, a Cuban doctor and scientist, proposed in 1881 that yellow fever might be transmitted by mosquitoes rather than direct human contact. Since the losses from yellow fever in the Spanish–American War in the 1890s were extremely high, Army doctors began research experiments with a team led by Walter Reed, and composed of doctors
Rat-bite fever underarm. Symptoms generally appear within 2 to 10 days of exposure to the infected animal. It begins with the fever and progresses to the rash on the hands and feet within 2 to 4 days. Rash appears all over the body with this form, but rarely causes joint pain. Two types of Gram-negative, facultatively anaerobic bacteria can cause the infection. Rat-bite fever transmitted by the Gram-negative coiled rod "Spirillum minus" (also known as "Spirillum minor") is more rare, and is found most often in Asia. In Japan, the disease is called "sodoku". Symptoms do not manifest for two to four