Hypotonic hyponatremia dramatic increase the serum sodium concentration and place the patient at risk for so-called "central pontine myelinolysis" (CPM). That disorder is characterized by major neurologic damage, often of a permanent nature. Because of the risk of CPM, people with low volume hyponatremia may eventually require water infusion as well as volume replacement. Doing so lessens the chance of a too rapid increase of the serum sodium level as blood volume rises and ADH levels fall. In people who are volume depleted, i.e., their blood volume is too low, ADH secretion is increased, since volume depletion is a potent stimulus for
Serum-separating tube Serum-separating tube Serum-separating tubes, also known as serum separator tubes or SSTs, are used in medical clinical chemistry tests requiring blood serum. SSTs are sometimes called "marble-top tubes," "tiger-tops," or "gold-topped tubes", referring to the stoppers which are either gold, red with a gold ring on top, or marbled red and grey. Marble-top tubes are also referred to as "tiger-tops" in some clinics. SPS tubes have a paler colour, sometimes leading confusion; these are known as "yellow tops" not "gold". Trademarked versions include Covidien "Corvac" tubes. They contain a special gel that separates blood cells from serum, as well as