Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Venom (1981 film) Venom (1981 film) Venom is a 1981 British horror film directed by Piers Haggard, written by Robert Carrington, based on Alan Scholefield's novel of the same name, and starring Klaus Kinski, Oliver Reed, Nicol Williamson, and Sarah Miles. An international criminal named Jacmel (Kinski) enlists Ruth Hopkins' maid Louise (George) and chauffeur Dave (Reed) in a scheme to kidnap her asthmatic ten-year-old son Philip (Holcomb) for ransom. As the plot begins to unfold, Philip has just brought home a snake from a local importer, unaware that his new pet has been accidentally switched with a deadly black mamba destined for