Alkaloid ("Agonopterix alstroemeriana)." This moth feeds on its highly toxic and alkaloid-rich host plant poison hemlock ("Conium maculatum") during its larval stage. "A. asltroemeriana" may benefit twofold from the toxicity of the naturally-occurring alkaloids, both through the unpalatability of the species to predators and through the ability of "A. alstroemeriana" to recognize "Conium maculatum" as the correct location for oviposition. Medical use of alkaloid-containing plants has a long history, and, thus, when the first alkaloids were isolated in the 19th century, they immediately found application in clinical practice. Many alkaloids are still used in medicine, usually in the form of salts,
U Should've Known Better song entered the "Billboard" Hot 100 chart, where it debuted at number 67 in the week of June 6, 2004, the second-highest debut of the week. "U Should've Known Better" remained twenty weeks on the chart, reaching its peak position of number 19 in its ninth week. It marked the second single from "After the Storm" to reach the top twenty on the Hot 100chart and, as the album's final single, would remain its second highest-charting offering behind leading single "So Gone." Although never released on a CD single or CD maxi single format, "U Should've Known Better" was also