Irvine Welsh His first novel, "Trainspotting", was published in 1993. Set in the mid-1980s, it uses a series of loosely connected short stories to tell the story of a group of characters tied together by decaying friendships, heroin addiction and stabs at escape from the oppressive boredom and brutality of their lives in the housing schemes. It was released to shock and outrage in some circles and great acclaim in others; "Time Out" called it "funny, unflinchingly abrasive, authentic and inventive", and "The Sunday Times" called Welsh "the best thing that has happened to British writing for decades". It was adapted as
Heroin used and faster the route of administration used, the higher potential risk for psychological addiction. Large doses of heroin can cause fatal respiratory depression, and the drug has been used for suicide or as a murder weapon. The serial killer Harold Shipman used diamorphine on his victims, and the subsequent Shipman Inquiry led to a tightening of the regulations surrounding the storage, prescribing and destruction of controlled drugs in the UK. John Bodkin Adams is also known to have used heroin as a murder weapon. Because significant tolerance to respiratory depression develops quickly with continued use and is lost just