Yellow fever was the first illness shown to be transmissible by filtered human serum and transmitted by mosquitoes, by Walter Reed around 1900. The positive-sense, single-stranded RNA is around 11,000 nucleotides long and has a single open reading frame encoding a polyprotein. Host proteases cut this polyprotein into three structural (C, prM, E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the enumeration corresponds to the arrangement of the protein coding genes in the genome. Minimal yellow fever virus (YFV) 3'UTR region is required for stalling of the host 5'-3' exonuclease XRN1. The UTR contains PKS3 pseudoknot structure which
Yellow fever in Buenos Aires Yellow fever in Buenos Aires The Yellow Fever in Buenos Aires was a series of epidemics that took place in 1852, 1858, 1870 and 1871, the latter being a disaster that killed about 8% of Porteños: in a city were the daily death rate was less than 20, there were days that killed more than 500 people. The Yellow Fever would have come from Asunción, Paraguay, brought by Argentine soldiers returning from the war just fought in that country, having previously spread in the city of Corrientes. As its worst, Buenos Aires population was reduced to a third because of