1793 Philadelphia yellow fever epidemic 1793 Philadelphia yellow fever epidemic During the Yellow Fever Epidemic of 1793 in Philadelphia, 5,000 or more people were listed in the official register of deaths between August 1 and November 9. The vast majority of them died of yellow fever, making the epidemic in the city of 50,000 people one of the most severe in United States history. By the end of September, 20,000 people had fled the city. The mortality rate peaked in October, before frost finally killed the mosquitoes and brought an end to the epidemic in November. Doctors tried a variety of treatments, but knew neither
Yellow fever serves as a molecular signal to stall the exonuclease and is the only viral requirement for subgenomic flavivirus RNA (sfRNA) production. The sfRNAs are a result of incomplete degradation of the viral genome by the exonuclease and are important for viral pathogenicity. Yellow fever belongs to the group of hemorrhagic fevers. The viruses infect, amongst others, monocytes, macrophages, and dendritic cells. They attach to the cell surface via specific receptors and are taken up by an endosomal vesicle. Inside the endosome, the decreased pH induces the fusion of the endosomal membrane with the virus envelope. The capsid enters the cytosol,