Erythema toxicum neonatorum Erythema toxicum neonatorum Erythema toxicum neonatorum (also known as erythema toxicum, urticaria neonatorum and toxic erythema of the newborn) is a common rash in neonates. It appears in up to half of newborns carried to term, usually between day 2–5 after birth; it does not occur outside the neonatal period. Erythema toxicum is characterized by blotchy red spots on the skin with overlying white or yellow papules or pustules. These lesions may be few or numerous. The eruption typically resolves within first two weeks of life and frequently individual lesions will appear and disappear within minutes or hours. It is
Smallpox malignant (or flat), and hemorrhagic. Historically, smallpox had an overall fatality rate of about 30 percent; the malignant and hemorrhagic forms were usually fatal. Ninety percent or more of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by the second day of the rash the macules became raised "papules". By the third or fourth day the papules filled with an opalescent fluid to become "vesicles". This fluid became opaque and turbid within 24–48 hours, giving them the appearance of pustules; the so-called pustules were filled with tissue debris, not pus. By the