Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Block sort Block sort Block sort, or block merge sort, is a sorting algorithm combining at least two merge operations with an insertion sort to arrive at in-place stable sorting. It gets its name from the observation that merging two sorted lists, and , is equivalent to breaking into evenly sized "blocks", inserting each block into under special rules, and merging pairs. One practical algorithm for O(log n) in place merging was proposed by Pok-Son Kim and Arne Kutzner in 2008. The outer loop of block sort is identical to a bottom-up merge sort, where each "level" of the sort merges pairs