Isotonic hyponatremia Isotonic hyponatremia Isotonic hyponatremia is a form of hyponatremia with mOsm measured between 280 and 295. It can be associated with pseudohyponatremia, or with isotonic infusion of glucose or mannitol. Certain conditions, such as extraordinarily high blood levels of lipid (hyperlipidemia/hypertriglyceridemia) or protein (hyperparaproteinemia), magnify the electrolyte exclusion effect. This interferes with the measurement of serum sodium concentration by certain methods, leading to an erroneously low "measurement" of sodium, or pseudohyponatremia. The methods affected are the flame-photometric and indirect (but not direct) ion-selective electrode assays. This is distinct from a true dilutional hyponatremia that can be caused by an osmotic
Scarlet fever serum Scarlet fever serum Scarlet fever serum was used beginning in November 1900 after its development in the Sero-Therapeutic Laboratory of Rudolph Hospital in Vienna, Austria. The serum was taken from the blood of horses. Infected children were injected in their abdominal skin by Dr. Paul Moser. Mortality rates from scarlet fever declined significantly following the use of the blood serum. Moser at first used scarlet fever serum primarily on the most severely sick persons. After achieving positive results it was applied in the first or second day following contraction of scarlet fever. In many cases the children treated demonstrated great