Mydriasis eye, and also to reduce painful ciliary muscle spasm (see cycloplegia). One effect of administration of a mydriatic is intolerance to bright light (photophobia). Purposefully-induced mydriasis via mydriatics is also used as a diagnostic test for Horner's syndrome. Mydriasis can be induced via modulation of adrenergic or cholinergic signalling. Within the adrenergic system, norepinephrine is a hormone and neurotransmitter responsible for regulating physiological processes in the body, including the involuntary muscles of the autonomic nervous system (such as the dilation or constriction of the pupil aperture via the muscles of the iris). Modulation of norepinephrine signalling can induce mydriasis. For
Batman: The Widening Gyre hiatuses and ran to July 2010 and Book 2 was pushed to late 2013. Ultimately, after further delays on Book 2, Smith decided to turn the second half of "Batman: Widening Gyre" into a separately titled mini-series called "Batman: Bellicosity". Following a tip from Nightwing, Batman discovers Arkham Asylum is completely overgrown with plant life. Upon investigation, Batman finds that Poison Ivy is currently in a dispute with Etrigan the Demon, and she has been turning Arkham Asylum into a fortress to protect herself. Batman and Etrigan do battle, but Batman is on the losing end. As Etrigan is about