Broad-spectrum antibiotic estimated 10-100 trillion multiple organisms that colonize the human body. As a side-effect of therapy, antibiotics can change the body's normal microbial content by attacking indiscriminately both the pathological and naturally occurring, beneficial or harmless bacteria found in the intestines, lungs and bladder. The destruction of the body's normal bacterial flora is thought to disrupt immunity, nutrition, and lead to a relative overgrowth in some bacteria or fungi. An overgrowth of drug-resistant microorganisms can lead to a secondary infection such as "Clostridium difficile" ("C. diff") or candidiasis ("thrush"). This side-effect is more likely with the use of broad-spectrum antibiotics, given
Algae their relationship with algae conjectured early. In other cases, some groups were originally characterized as parasitic algae (e.g., "Chlorochytrium"), but later were seen as endophytic algae. Some filamentous bacteria (e.g., "Beggiatoa") were originally seen as algae. Furthermore, groups like the apicomplexans are also parasites derived from ancestors that possessed plastids, but are not included in any group traditionally seen as algae. The first land plants probably evolved from shallow freshwater charophyte algae much like "Chara" almost 500 million years ago. These probably had an isomorphic alternation of generations and were probably filamentous. Fossils of isolated land plant spores suggest land