Pupillary response Pupillary response Pupillary response is a physiological response that varies the size of the pupil, via the optic and oculomotor cranial nerve. A constriction response (miosis), is the narrowing of the pupil, which may be caused by scleral buckles or drugs such as opiates/opioids or anti hypertension medications. Constriction of the pupil occurs when the circular muscle, controlled by the parasympathetic nervous system (PSNS), contracts. A dilation response (mydriasis), is the widening of the pupil and may be caused by adrenaline, anticholinergic agents or drugs such as MDMA, cocaine, amphetamines and some hallucinogenics. Dilation of the pupil occurs when the
The World Is What It Is The World Is What It Is The World Is What It Is: The Authorized Biography of V. S. Naipaul is a biography of the Nobel Prize-winning author V. S. Naipaul by Patrick French. It was published in 2008 (by Picador in the UK and Knopf in the USA). The title is a quotation from Naipaul's book "A Bend in the River". "The world is what it is; men who are nothing, who allow themselves to become nothing, have no place in it." French deals with Naipaul's family background and his life from his birth in 1932 until his second marriage