Yellow fever was the first illness shown to be transmissible by filtered human serum and transmitted by mosquitoes, by Walter Reed around 1900. The positive-sense, single-stranded RNA is around 11,000 nucleotides long and has a single open reading frame encoding a polyprotein. Host proteases cut this polyprotein into three structural (C, prM, E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the enumeration corresponds to the arrangement of the protein coding genes in the genome. Minimal yellow fever virus (YFV) 3'UTR region is required for stalling of the host 5'-3' exonuclease XRN1. The UTR contains PKS3 pseudoknot structure which
Yellow Fever (play) Yellow Fever (play) Yellow Fever is a play by R. A. Shiomi which takes place on Powell Street in Japantown, Vancouver, a gathering place for the local Japanese-Canadian culture. Set in the 1970s, the Sam Spade-like main character, Sam Shikaze, must work to unravel the mysteries that surround him. First produced by the Pan Asian Repertory Theatre in 1982, it received positive reviews and had a successful run off-Broadway. Sam Shikaze, a smooth private-eye, narrates his own story about what happened when he was hired to find the missing Cherry Blossom Queen. He is soon trapped in a web of