Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Venom (Bullet for My Valentine album) is credited as a band member but did not perform on this album; Tuck recorded all bass guitar parts instead. Mathias later said in an interview that he hopes to be involved in future band projects. "Venom" received mixed reviews from music critics. At Metacritic, which assigns a rating out of 100 to reviews from mainstream critics, the album has an average score of 58/100 based on 8 reviews, indicating "mixed or average reviews". British magazine "Kerrang!" awarded the album 4 stars, saying that "Venom has injected a whole new life into the British metal heroes." "Alternative Press" and "AllMusic"