Central pontine myelinolysis sodium concentration. Three to five days later, a second phase of neurological manifestations occurs correlating with the onset of myelinolysis. Observable immediate precursors may include seizures, disturbed consciousness, gait changes, and decrease or cessation of respiratory function. The classical clinical presentation is the progressive development of spastic quadriparesis, pseudobulbar palsy, and emotional lability (pseudobulbar affect), with other more variable neurological features associated with brainstem damage. These result from a rapid myelinolysis of the corticobulbar and corticospinal tracts in the brainstem. The most common cause is overly rapid correction of low blood sodium levels (hyponatremia). Apart from rapid correction of hyponatraemia,
Autologous conditioned serum the procedure performed by Wehling, is one famous case based on his recovery from his previously poor knees.Some basketball fans refer to the procedure as the "Kobe Procedure". The procedure cost €6,000 (about $7,400) as of July 2012. The treatment is not covered by health insurance. Autologous conditioned serum Autologous conditioned serum, also known as Orthokine and Regenokine, is an experimental procedure in which a person's own blood is extracted, manipulated, and then reintroduced with claims benefit in osteoarthritis. There is limited evidence on safety and effectiveness as of 2017. It is not included in medical guidelines as of 2017.