Lixivaptan BALANCE study is a 650-patient Phase III, global, multi-center, randomized, placebo-controlled, double-blind, study of lixivaptan for hyponatremia in patients with heart failure. The primary objective is to evaluate the safety and effectiveness of lixivaptan, when compared to the placebo, in increasing serum sodium from baseline in heart failure patients with hyponatremia. In previous studies, lixivaptan improved blood sodium levels, lowered body weight and increased urine volume. Those studies suggest that lixivaptan may play an important role in treating hyponatremia and the signs and symptoms of water retention associated with heart failure, Syndrome of Inappropriate Anti-Diuretic Hormone(SIADH), and Liver Cirrhosis with
Human Element believes it is the fear that the walking dead instill in the survivors, who lead them to do unreasonable things to survive. The game focuses on the survivors more so than the zombies, "the human element", and takes place 35 years after the zombie apocalypse began. It can be played across multiple devices; an example given is that one player could play the console version for hundreds of hours, just for the action, whereas an intelligent class player, playing on a tablet, can join into the previous player's alliance and scavenge for them, and then benefit from the buffs given