Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Evolution of snake venom eggs, meaning that the snake had no use for its venom. This has led biologists to suggest that if venom is not used by a species, it is rapidly lost. Venom atrophication has also occurred following the evolution of constriction as a method of prey capture that does not require venom. Constriction is hypothesized to have evolved independently in several lineages. North American ‘rat snakes’ such as the Corn snake "Pantherophis guttatus" use constriction to trap and kill their rodent prey, and do not possess functional venom. A similar process has occurred in the African colubrid lineage Lamprophiidae, such as