Ionizing radiation from medical imaging. Average man-made exposure is much higher in developed countries, mostly due to CT scans and nuclear medicine. Natural background radiation comes from five primary sources: cosmic radiation, solar radiation, external terrestrial sources, radiation in the human body, and radon. The background rate for natural radiation varies considerably with location, being as low as 1.5 mSv/a (1.5 mSv per year) in some areas and over 100 mSv/a in others. The highest level of purely natural radiation recorded on the Earth's surface is 90 µGy/h (0.8 Gy/a) on a Brazilian black beach composed of monazite. The highest background radiation
Biological effects of radiation on the epigenome in LINE1 protein levels. Increased transcription of LINE1 transposable elements results in greater mobilization of the LINE1 loci and therefore increases genomic instability. Irradiated cells can be linked to a variety of histone modifications. Ionizing radiation in breast cancer cell inhibits H4 lysine tri-methylation. Mouse models exposed to high levels of X-ray irradiation exhibited a decrease in both the tri-methylation of H4-Lys20 and the compaction of the chromatin. With the loss of tri-methylation of H4-Lys20, DNA hypomethylation increased resulting in DNA damage and increased genomic instability. Breaks in DNA due to ionizing radiation can be repaired. New DNA synthesis by