2016 Angola and DR Congo yellow fever outbreak case. Between 18 March and 22 April, the WHO was notified of 11 imported cases in China. Officials in Asia were concerned about the threat of yellow fever. On 28 March, ProMED-mail moderators Jack Woodall and Tom Yuill issued a strongly worded warning on the threat of yellow fever for countries that have endemic dengue fever (and thus the mosquito vector of yellow fever and dengue fever, Aedes aegypti), and particularly for countries in Asia, where until recently yellow fever has never appeared. Urban populations and mosquito-infested slums in Asia and Africa are much larger than in the past. A
Yellow fever they reach the liver and infect hepatocytes (probably indirectly via Kupffer cells), which leads to eosinophilic degradation of these cells and to the release of cytokines. Apoptotic masses known as Councilman bodies appear in the cytoplasm of hepatocytes. Fatality may occur when cytokine storm, shock, and multiple organ failure follow. Yellow fever is most frequently a clinical diagnosis, made from symptoms and where the infected person was before becoming ill. Mild courses of the disease can only be confirmed virologically. Since mild courses of yellow fever can also contribute significantly to regional outbreaks, every suspected case of yellow fever (involving