Honey bee as apitoxin, carries several active components, the most abundant of which is melittin, and the most biologically active are enzymes, particularly phospholipase A2. Bee venom is under laboratory and clinical research for its potential properties and uses in reducing risks for adverse events from bee venom therapy, rheumatoid arthritis, and use as an immunotherapy for protection against allergies from insect stings. Bee venom products are marketed in many countries, but, as of 2018, there are no approved clinical uses for these products which carry various warnings for potential allergic reactions. With an increased number of honey bees in a specific
Venom "Polistes fuscatus", the female continuously releases a venom that contains a sex pheromone that induces copulatory behavior in males. In "Polistes exclamans", venom is used as an alarm pheromone, coordinating a response with from the nest and attracting nearby wasps to attack the predator. In "Dolichovespula arenaria," the observed spraying of venom out of their sting has been seen from workers in large colonies. In other cases like "Parischnogaster striatula", the venom is applied all over their body as an antimicrobial protection. The venom from "Agelaia pallipes" has inhibitory effects on processes like chemotaxis and hemolysis which can lead to