Ionizing radiation fields. Natural sources include the sun, lightning and supernova explosions. Artificial sources include nuclear reactors, particle accelerators, and x-ray tubes. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) itemized types of human exposures. The International Commission on Radiological Protection manages the International System of Radiological Protection, which sets recommended limits for dose uptake. Background radiation comes from both natural and man-made sources. The global average exposure of humans to ionizing radiation is about 3 mSv (0.3 rem) per year, 80% of which comes from nature. The remaining 20% results from exposure to man-made radiation sources, primarily
Biological effects of radiation on the epigenome for many cell divisions. One way this non-Mendelian mode of inheritance can be explained is through epigenetic mechanisms. Ionizing radiation exposure affects patterns of DNA methylation. Breast cancer cells treated with fractionated doses of ionizing radiation showed DNA hypomethylation at the various gene loci; dose fractionation refers to breaking down one dose of radiation into separate, smaller doses. Hypomethylation of these genes correlated with decreased expression of various DNMTs and methyl CpG binding proteins. LINE1 transposable elements have been identified as targets for ionizing radiation. The hypomethylation of LINE1 elements results in activation of the elements and thus an increase