Central pontine myelinolysis sodium concentration. Three to five days later, a second phase of neurological manifestations occurs correlating with the onset of myelinolysis. Observable immediate precursors may include seizures, disturbed consciousness, gait changes, and decrease or cessation of respiratory function. The classical clinical presentation is the progressive development of spastic quadriparesis, pseudobulbar palsy, and emotional lability (pseudobulbar affect), with other more variable neurological features associated with brainstem damage. These result from a rapid myelinolysis of the corticobulbar and corticospinal tracts in the brainstem. The most common cause is overly rapid correction of low blood sodium levels (hyponatremia). Apart from rapid correction of hyponatraemia,
Human Element believes it is the fear that the walking dead instill in the survivors, who lead them to do unreasonable things to survive. The game focuses on the survivors more so than the zombies, "the human element", and takes place 35 years after the zombie apocalypse began. It can be played across multiple devices; an example given is that one player could play the console version for hundreds of hours, just for the action, whereas an intelligent class player, playing on a tablet, can join into the previous player's alliance and scavenge for them, and then benefit from the buffs given