Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Hennessey Venom F5 Hennessey Venom F5 The Hennessey Venom F5 is an upcoming American high-performance sports car manufactured by the newly found vehicle-manufacturing company Hennessey Special Vehicles which was established in 2017. The Venom F5 will be the first vehicle to be developed and manufactured in-house from the company including the chassis, body work, engine and exhaust system developed by the company along with other bespoke components. The F5 name is a reference to the F5 tornado, the fastest in the Fujita scale, reaching as high as . The Hennessey Venom F5 was unveiled at the SEMA Show in Las Vegas, Nevada, on