Central pontine myelinolysis sodium concentration. Three to five days later, a second phase of neurological manifestations occurs correlating with the onset of myelinolysis. Observable immediate precursors may include seizures, disturbed consciousness, gait changes, and decrease or cessation of respiratory function. The classical clinical presentation is the progressive development of spastic quadriparesis, pseudobulbar palsy, and emotional lability (pseudobulbar affect), with other more variable neurological features associated with brainstem damage. These result from a rapid myelinolysis of the corticobulbar and corticospinal tracts in the brainstem. The most common cause is overly rapid correction of low blood sodium levels (hyponatremia). Apart from rapid correction of hyponatraemia,
Human Element engage and impact in the scenarios you will be presented with on a physical and moral level that you approach this world." The game was announced on June 1, 2012, and more details were released in the July edition of "Game Informer". On July 19, 2012, Robotoki's president Robert Bowling announced that "Human Element" would have an episodic prequel released exclusively on the Ouya, as a first-party title. But it was later announced that the studio decided to cancel the Ouya version of Human Element "very early on" and switch focus to the open-world experience on other more powerful platforms.