Yellow fever reach the stomach of the mosquito, and if the virus concentration is high enough, the virions can infect epithelial cells and replicate there. From there, they reach the haemocoel (the blood system of mosquitoes) and from there the salivary glands. When the mosquito next sucks blood, it injects its saliva into the wound, and the virus reaches the bloodstream of the bitten person. Transovarial and transstadial transmission of the yellow fever virus within "A. aegypti", that is, the transmission from a female mosquito to her eggs and then larvae, are indicated. This infection of vectors without a previous blood meal
1793 Philadelphia yellow fever epidemic atmosphere that might last 50 years and make deadly epidemics almost certain. Yellow fever epidemics became seen as a national crisis. When in 1855 a French doctor published an 813-page history of yellow fever in Philadelphia, covering outbreaks from 1699 to 1854, he devoted only a few pages to the 1793 epidemic. General 20th-century US histories, such as the 10-volume "Great Epochs in American History," published in 1912, used short excerpts from Carey's account. The first history of the epidemic to draw on more primary sources was J. H. Powell's "Bring Out Your Dead" (1949), but he did not use