Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Venom (Bullet for My Valentine album) Venom (Bullet for My Valentine album) Venom is the fifth studio album by the Welsh heavy metal band Bullet for My Valentine, released on 14 August 2015 via RCA Records, their second and last album under the label. It is the first album by the band since the departure of bassist Jason "Jay" James, which was announced in February 2015 while the band was recording the album. Jamie Mathias was announced as his replacement on 18 May 2015, along with the album's title, release date and release of the album's first single, "No Way Out". This would also be the