Yellow fever the introduction of sugar plantations created the conditions for mosquito and viral reproduction, and subsequent outbreaks of yellow fever. Deforestation reduced populations of insectivorous birds and other creatures that fed on mosquitoes and their eggs. Although yellow fever is most prevalent in tropical-like climates, the northern United States were not exempted from the fever. The first outbreak in English-speaking North America occurred in New York City in 1668, and a serious one afflicted Philadelphia in 1793. English colonists in Philadelphia and the French in the Mississippi River Valley recorded major outbreaks in 1669, as well as those occurring later in
Rat-bite fever underarm. Symptoms generally appear within 2 to 10 days of exposure to the infected animal. It begins with the fever and progresses to the rash on the hands and feet within 2 to 4 days. Rash appears all over the body with this form, but rarely causes joint pain. Two types of Gram-negative, facultatively anaerobic bacteria can cause the infection. Rat-bite fever transmitted by the Gram-negative coiled rod "Spirillum minus" (also known as "Spirillum minor") is more rare, and is found most often in Asia. In Japan, the disease is called "sodoku". Symptoms do not manifest for two to four