Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Mainframe sort merge CASORT) have also adopted SORT as an alias for their product. DFSORT is often referred to by its program name, ICEMAN (component ICE; the original OS/360 Sort/Merge program name was IERRCO00, component IER, also with "alias" SORT). Mainframe sort merge The Sort/Merge utility is a mainframe program to sort records in a file into a specified order, merge pre-sorted files into a sorted file, or copy selected records. Internally, these utilities use one or more of the standard sorting algorithms, often with proprietary fine-tuned code. Mainframes were originally supplied with limited main memory by today's standards and the amount of