Osmotherapy inhibits these channels. Vasopressin receptors activated by vasopressin are found on the basolateral membrane of the cells lining the collecting ducts of the kidneys. Aneurysmal subarachnoid hemorrhage(aSAH) results in hyponatremia which leads to water retention and antidiuretic hormone release causing increase in intracranial pressure and formation of cerebral edema. This can be prevented by administration of conivaptan, a safe FDA approved drug that treats euvolemic hyponatremia. Through the process of aquaresis, conivapten which is a vasopressin receptor antagonist improves serum sodium concentration while eliminating free water without having any negative effect on systolic blood pressure and pulse rate. Since it
Antireticular cytotoxic serum Antireticular cytotoxic serum Anti-reticular Cytotoxic Serum is made from the blood of a rabbit that has been injected with homogenized cadaver spleen and rib marrow. In small quantities it can aid animal growth, but is toxic in large doses. It was first developed by Alexander A. Bogomolets in 1936. "It was a "miracle" that Professor Bogomolets made dying people walk with blood of cadavers circulating through their bodies, or hoped to extend our life-span for 150 years with the help of the A.C.S serum" - Red Miracle: The Story of Soviet Medicine by Edward Podolsky "World Book Encyclopedia", 1967 Edition,