Yellow fever was the first illness shown to be transmissible by filtered human serum and transmitted by mosquitoes, by Walter Reed around 1900. The positive-sense, single-stranded RNA is around 11,000 nucleotides long and has a single open reading frame encoding a polyprotein. Host proteases cut this polyprotein into three structural (C, prM, E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the enumeration corresponds to the arrangement of the protein coding genes in the genome. Minimal yellow fever virus (YFV) 3'UTR region is required for stalling of the host 5'-3' exonuclease XRN1. The UTR contains PKS3 pseudoknot structure which
1793 Philadelphia yellow fever epidemic the personal letters, which are largely held by Quaker colleges in the area. While Powell did not write a scholarly history of the epidemic, his work reviewed its historical importance. Since the mid-twentieth century, scholars have studied aspects of the epidemic, first in papers. For example, Martin Pernick's "Politics, Parties, and Pestilence: Epidemic Yellow Fever in Philadelphia and the Rise of the First Party System," developed statistical evidence to show that Republican doctors generally used Rush's therapies and Federalist doctors used Kuhn's. Scholars celebrated the 200th anniversary of the epidemic with the publication of papers on various aspects of the