Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Spider-Man: The Venom Saga symbiote owes its earthly return, to steal a machine from Stark Enterprises capable of releasing Dormammu from his own far-off dimension. When Venom battles Spider-Man and War Machine, he is easily defeated by the two heroes. Baron Mordo and Dormammu help Eddie Brock's insane cell-mate Cletus Kassidy bond with a symbiote, who later dubs himself Carnage. Carnage then assists Venom in his task to retrieve the technology from Stark Enterprises, though when Carnage attempts to destroy Spider-Man, Venom attacks him, telling him that Spider-Man is Venom's and Venom's only. When Venom refuses to continue to work for Dormammu, Carnage is