Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Evolution of snake venom contain more than 100 distinct proteins. The composition of this mixture has been shown to vary geographically, and to be related to the prey species available in a certain region. Snake venom has generally evolved very quickly, with changes occurring faster in the venom than in the rest of the organism. Some traditional hypotheses of snake venom evolution have supported the idea that most snakes inject far more venom into their prey than is required to kill them; thus, venom composition would not be subject to natural selection. This is known as the "overkill" hypothesis. However, recent studies of the