A Treatise of Human Nature taste to be in the other), arguing that unextended perceptions must somehow exist without having a location. But the contrary problem arises for dualists: how can extended perceptions (of extended objects) possibly be conjoined to a simple substance? Indeed, Hume waggishly adds, this is basically the same problem that theologians commonly press against Spinoza's naturalistic metaphysics: thus if the theologians manage to solve the problem of extended perceptions belonging to a simple substance, then they give "that famous atheist" Spinoza a solution to the problem of extended objects as modes of a simple substance. Finally, Hume examines "causal relations", arguing
Phomoxanthone A PXA and PXB were discovered in 2001, and their preparation by isolation from "Phomopsis" fungal cultures was described in the corresponding publication. Briefly, a MeOH extract of a "Phomopsis" culture is mixed with HO and washed with hexane. The aqueous phase is then dried and the residue is dissolved in EtOAc, washed with HO, concentrated and repeatedly purified by size-exclusion chromatography. The resulting mixture of PXA and PXB is separated by HPLC. A modified method, in which the initial extraction is done with EtOAc instead of MeOH and the drying step is skipped, was described in 2013. Phomoxanthone A was