Lixivaptan BALANCE study is a 650-patient Phase III, global, multi-center, randomized, placebo-controlled, double-blind, study of lixivaptan for hyponatremia in patients with heart failure. The primary objective is to evaluate the safety and effectiveness of lixivaptan, when compared to the placebo, in increasing serum sodium from baseline in heart failure patients with hyponatremia. In previous studies, lixivaptan improved blood sodium levels, lowered body weight and increased urine volume. Those studies suggest that lixivaptan may play an important role in treating hyponatremia and the signs and symptoms of water retention associated with heart failure, Syndrome of Inappropriate Anti-Diuretic Hormone(SIADH), and Liver Cirrhosis with
Human Element Human Element Human Element was an online multiplayer video game under development by Robotoki for Microsoft Windows, PlayStation 4, and Xbox One. Development was halted when the studio was closed as indicated by a farewell message on Robotoki's (now defunct) blog on January 20, 2015, by the studio's founder, Robert Bowling. "Human Element" is the first game being developed by the independent game company Robotoki, which was formed by Robert Bowling after he left Infinity Ward following the release of "". The premise of the game centers on the question, "What is the greatest threat in a zombie apocalypse?"; Bowling