Ionizing radiation members, to comply with a European Directive. The FAA has a recommended limit of 1 mSv total for a pregnancy, and no more than 0.5 mSv per month. Information originally based on "Fundamentals of Aerospace Medicine" published in 2008. Hazardous levels of ionizing radiation are signified by the trefoil sign on a yellow background. These are usually posted at the boundary of a radiation controlled area or in any place where radiation levels are significantly above background due to human intervention. The red ionizing radiation warning symbol (ISO 21482) was launched in 2007, and is intended for IAEA Category 1,
Biological effects of radiation on the epigenome and structure and therefore effectively destabilizes the cell. Ionizing radiation causes the cell to generate increased ROS and the increase of this species damages biological macromolecules. In order to compensate for this increased radical species, cells adapt to IR induced oxidative effects by modifying the mechanisms of epigenetic gene regulation. There are 4 epigenetic modifications that can take place: ROS generated by ionizing radiation chemically modify histones which can cause a change in transcription. Oxidation of cellular lipid components result in an electrophilic molecule formation. The electrophilic molecule binds to the lysine residues of histones causing a ketoamide adduct formation.