Broad-spectrum antibiotic estimated 10-100 trillion multiple organisms that colonize the human body. As a side-effect of therapy, antibiotics can change the body's normal microbial content by attacking indiscriminately both the pathological and naturally occurring, beneficial or harmless bacteria found in the intestines, lungs and bladder. The destruction of the body's normal bacterial flora is thought to disrupt immunity, nutrition, and lead to a relative overgrowth in some bacteria or fungi. An overgrowth of drug-resistant microorganisms can lead to a secondary infection such as "Clostridium difficile" ("C. diff") or candidiasis ("thrush"). This side-effect is more likely with the use of broad-spectrum antibiotics, given
Bacteria sizes, called morphologies. Bacterial cells are about one-tenth the size of eukaryotic cells and are typically 0.5–5.0 micrometres in length. However, a few species are visible to the unaided eye—for example, "Thiomargarita namibiensis" is up to half a millimetre long and "Epulopiscium fishelsoni" reaches 0.7 mm. Among the smallest bacteria are members of the genus "Mycoplasma", which measure only 0.3 micrometres, as small as the largest viruses. Some bacteria may be even smaller, but these ultramicrobacteria are not well-studied. Most bacterial species are either spherical, called "cocci" ("sing". coccus, from Greek "kókkos", grain, seed), or rod-shaped, called "bacilli" ("sing". bacillus,