Broad-spectrum antibiotic estimated 10-100 trillion multiple organisms that colonize the human body. As a side-effect of therapy, antibiotics can change the body's normal microbial content by attacking indiscriminately both the pathological and naturally occurring, beneficial or harmless bacteria found in the intestines, lungs and bladder. The destruction of the body's normal bacterial flora is thought to disrupt immunity, nutrition, and lead to a relative overgrowth in some bacteria or fungi. An overgrowth of drug-resistant microorganisms can lead to a secondary infection such as "Clostridium difficile" ("C. diff") or candidiasis ("thrush"). This side-effect is more likely with the use of broad-spectrum antibiotics, given
Cavalier-Smith's system of classification had been subdivided into twelve phyla: The protozoa were originally classified as members of the animal kingdom. Now they are classified as multiple separate groups. Zoology is the study of animals while botany is the study of plants. While zoologists divided the animal kingdom into phyla, botanists carved the plant kingdom into "divisions". By 1940, five divisions were recognized: Fungi and bacteria were included within the plant division thallophyta. Today, bacteria are no longer classified as plants and fungi are known to be more closely related to animals than to plants. By mid-nineteenth century, microscopic organisms were generally classified into