History of yellow fever as a result of the numerous deaths, of the French company licensed to build the canal resulted in a massive financial crisis in France. History of yellow fever The evolutionary origins of yellow fever most likely lie in Africa. Phylogenetic analyses indicate that the virus originated from East or Central Africa, with transmission between primates and humans, and spread from there to West Africa. The virus as well as the vector "Aedes aegypti", a mosquito species, were probably brought to the western hemisphere and the Americas by slave trade ships from Africa after the first European exploration in 1492. The
Yellow fever on the African continent. In 2008, the largest number of recorded cases was in Togo. In 2016, a large outbreak originated in Angola and spread to neighboring countries before being contained by a massive vaccination campaign. In March and April, 11 cases were reported in China, the first appearance of the disease in Asia in recorded history. Phylogenetic analysis has identified seven genotypes of yellow fever viruses, and they are assumed to be differently adapted to humans and to the vector "A. aegypti". Five genotypes (Angola, Central/East Africa, East Africa, West Africa I, and West Africa II) occur only in