Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Proxmap sort few buckets with too many keys); if many values occur close together, they will all fall into a single bucket and performance will be severely diminished. This behavior also holds for ProxmapSort: if the buckets are too large, its performance will degrade severely. Proxmap sort ProxmapSort, or Proxmap sort, is a sorting algorithm that works by partitioning an array of data items, or keys, into a number of "subarrays" (termed buckets, in similar sorts). The name is short for computing a "proximity map," which indicates for each key K the beginning of a subarray where K will reside in the