Brownian motion apart once the particle is in motion. Also, there would be a distribution of different possible Δ"V"s instead of always just one in a realistic situation. The diffusion equation yields an approximation of the time evolution of the probability density function associated to the position of the particle going under a Brownian movement under the physical definition. The approximation is valid on short timescales. The time evolution of the position of the Brownian particle itself is best described using Langevin equation, an equation which involves a random force field representing the effect of the thermal fluctuations of the solvent on
Brownian motion "x", 1 ≤ "i" ≤ "m", is given by ½Δ, where Δ is the Laplace–Beltrami operator given in local coordinates by where ["g"] = ["g"] in the sense of the inverse of a square matrix. The narrow escape problem is a ubiquitous problem in biology, biophysics and cellular biology which has the following formulation: a Brownian particle (ion, molecule, or protein) is confined to a bounded domain (a compartment or a cell) by a reflecting boundary, except for a small window through which it can escape. The narrow escape problem is that of calculating the mean escape time. This time