Toe the line of athletics where it describes runners poised at the starting line, and in the context of behavior where the miscreant is expected to "toe the line." The first published use in a political context was in March 1826, where Willie Mangum of the United States House of Representatives proposed that "every member might 'toe the mark'." The behavioral use also stems from around that time. The term continues to be used in the context of cross-country and track and field running, although sometimes also symbolically in bicycle races to be at your mark along the starting line before a race.
Americans For Medical Advancement not,” and that the organization “explores the differences between the two.” What sets it apart is that it focuses “on the harm that is done to humans” and that animal protectionists are concerned about the harm done to animals. Americans for Medical Advancement targets their work to improve healthcare. The way the organization hopes to do so is by developing safer, more efficient techniques to use in labs. Since AFMA believes that animals do not give an accurate reading of how drugs will make a human react, the first step would be eliminating animal testing in the development of drugs