Central pontine myelinolysis sodium concentration. Three to five days later, a second phase of neurological manifestations occurs correlating with the onset of myelinolysis. Observable immediate precursors may include seizures, disturbed consciousness, gait changes, and decrease or cessation of respiratory function. The classical clinical presentation is the progressive development of spastic quadriparesis, pseudobulbar palsy, and emotional lability (pseudobulbar affect), with other more variable neurological features associated with brainstem damage. These result from a rapid myelinolysis of the corticobulbar and corticospinal tracts in the brainstem. The most common cause is overly rapid correction of low blood sodium levels (hyponatremia). Apart from rapid correction of hyponatraemia,
Blood libel Blood libel Blood libel (also blood accusation) is an antisemitic canard accusing Jews of kidnapping and murdering the children of Christians in order to use their blood as part of religious rituals. Historically, these claims—alongside those of well poisoning and host desecration—have been a major theme of the persecution of Jews in Europe. Blood libels typically say that Jews require human blood for the baking of matzos for Passover, although this element was allegedly absent in the earliest cases which claimed that then-contemporary Jews reenacted the crucifixion. The accusations often assert that the blood of the children of Christians is