Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Venom (comic book) abusing his father's body; he is eventually defeated and incarcerated by Venom. According to DCD, Remender's "Venom" #1 was the 128th-bestselling single issue of 2011 (based on an estimated 65,600 issues shipped). "Venom" #2 was number 389; sales dropped for each successive issue for the year, finishing at number 802 with "Venom" #11 (based on an estimated 28,700 issues shipped). "Venom" #22 (October 2012), Remender's final issue, sold an estimated 26,734 issues. The trade paperback "Venom Volume 1" ("Venom" #1-5) was the 134th-bestselling trade paperback of 2012, followed by "Circle of Four" at number 359 and "Savage Six" at number