1793 Philadelphia yellow fever epidemic the origin of the fever nor that it was transmitted by mosquitoes (which was not verified until the late nineteenth century). The mayor and a committee of two dozen organized a fever hospital at Bush Hill and other crisis measures. The assistance of the Free African Society was requested by the city and readily agreed to by the members, based on the mistaken assumption that native Africans would have the same partial immunity to the new disease as many had to malaria, the most common source of fever epidemics during the summer months. Black nurses aided the sick and the
Yellow fever serves as a molecular signal to stall the exonuclease and is the only viral requirement for subgenomic flavivirus RNA (sfRNA) production. The sfRNAs are a result of incomplete degradation of the viral genome by the exonuclease and are important for viral pathogenicity. Yellow fever belongs to the group of hemorrhagic fevers. The viruses infect, amongst others, monocytes, macrophages, and dendritic cells. They attach to the cell surface via specific receptors and are taken up by an endosomal vesicle. Inside the endosome, the decreased pH induces the fusion of the endosomal membrane with the virus envelope. The capsid enters the cytosol,