Hyponatremia feedback loop is overwhelmed by increased fluid intake, 2) the feedback loop malfunctions such that ADH is always "turned on"; 3) the receptors in the kidney are always "open" regardless of there being no signal from ADH to be open; or 4) there is an increased ADH even though there is no normal stimulus (elevated serum sodium) for ADH to be increased. Hyponatremia occurs in one of two ways: either the osmoreceptor-aquaporin feedback loop is "overwhelmed", or it is "interrupted". If it is interrupted, it is either "related" or "not related" to ADH. If the feedback system is overwhelmed, this
Human Element engage and impact in the scenarios you will be presented with on a physical and moral level that you approach this world." The game was announced on June 1, 2012, and more details were released in the July edition of "Game Informer". On July 19, 2012, Robotoki's president Robert Bowling announced that "Human Element" would have an episodic prequel released exclusively on the Ouya, as a first-party title. But it was later announced that the studio decided to cancel the Ouya version of Human Element "very early on" and switch focus to the open-world experience on other more powerful platforms.