Yellow fever in the Golgi apparatus by the host protein furin, which cleaves prM to M. This releases E from the complex which can now take its place in the mature, infectious virion. Yellow fever virus is mainly transmitted through the bite of the yellow fever mosquito "Aedes aegypti", but other mostly "Aedes" mosquitoes such as the tiger mosquito ("Aedes albopictus") can also serve as a vector for this virus. Like other arboviruses which are transmitted by mosquitoes, the yellow fever virus is taken up by a female mosquito when it ingests the blood of an infected human or another primate. Viruses
1793 Philadelphia yellow fever epidemic was also advocated by Dr. Edward Stevens, who in mid-September claimed it had cured Alexander Hamilton, Secretary of the Treasury, of the fever. Rush searched the medical literature for other approaches. Benjamin Franklin had given him letters sent by Dr. John Mitchell, related to treating patients during a 1741 yellow fever outbreak in Virginia. (Franklin never published the letters.) Mitchell noted that the stomach and intestines filled with blood and that these organs had to be emptied at all costs. "On this account," Mitchell argued, "an ill-timed scrupulousness about the weakness of the body is of bad consequences in these