Hypotonic hyponatremia dramatic increase the serum sodium concentration and place the patient at risk for so-called "central pontine myelinolysis" (CPM). That disorder is characterized by major neurologic damage, often of a permanent nature. Because of the risk of CPM, people with low volume hyponatremia may eventually require water infusion as well as volume replacement. Doing so lessens the chance of a too rapid increase of the serum sodium level as blood volume rises and ADH levels fall. In people who are volume depleted, i.e., their blood volume is too low, ADH secretion is increased, since volume depletion is a potent stimulus for
Human Element believes it is the fear that the walking dead instill in the survivors, who lead them to do unreasonable things to survive. The game focuses on the survivors more so than the zombies, "the human element", and takes place 35 years after the zombie apocalypse began. It can be played across multiple devices; an example given is that one player could play the console version for hundreds of hours, just for the action, whereas an intelligent class player, playing on a tablet, can join into the previous player's alliance and scavenge for them, and then benefit from the buffs given