Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Alternative versions of Venom with a genuine sense of bitterness and sorrow, describing himself as a responsibility that Spider-Man neglected, leaving the wallcrawler at a loss for words. Defeated, the Sinister Six, Spidey and Venom have their final battle, in which Sandman gives Spider-Man a detonator to make all the Sinners explode. Spidey presses the button, most likely killing Venom and putting an end to his "Reign" once and for all. In "Old Man Logan", the symbiote appears to be following Logan and Hawkeye, having bonded to a Savage Land tyrannosaurus rex. It is stopped by Black Bolt. Another symbiote is seen in the