Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Stooge sort Stooge sort Stooge sort is a recursive sorting algorithm. It is notable for its exceptional bad time complexity of . The running time of the algorithm is thus slower compared to reasonable sorting algorithms, and is slower than Bubble sort, a canonical example of a fairly inefficient sort. It is however more efficient than Slowsort. The name comes from The Three Stooges. The algorithm is defined as follows: It is important to get the integer sort size used in the recursive calls by rounding the 2/3 "upwards", e.g. rounding 2/3 of 5 should give 4 rather than 3, as otherwise