Ionizing radiation a cancer per dose model to assert that such activities cause several hundred cases of cancer per year, an application of the widely accepted Linear no-threshold model (LNT). The International Commission on Radiological Protection recommends limiting artificial irradiation to the public to an average of 1 mSv (0.001 Sv) of effective dose per year, not including medical and occupational exposures. In a nuclear war, gamma rays from both the initial weapon explosion and fallout would be the sources of radiation exposure. Massive particles are a concern for astronauts outside the earth's magnetic field who would receive solar particles from solar
Biological effects of radiation on the epigenome epigenetic up-regulation of genes. A similar mechanism involves the ataxia telangiectasia mutated (ATM) serine/threonine kinase which is an enzyme involved in the repair of double stranded breaks caused by ionizing radiation. ATM phosphorylates KAP1 which causes the heterochromatin to relax, allowing increased transcription to occur. The DNA mismatch repair gene (MSH2) promoter has shown a hypermethylation pattern when exposed to ionizing radiation. Reactive oxygen species induce the oxidization of deoxyguanosine into 8-hydroxydeoxyguanosine (8-OHdG) causing a change in chromatin structure. Gene promoters that contain 8-OHdG deactivate the chromatin by inducing trimethyl-H3K27 in the genome. Other enzymes such as transglutaminases (TGs) control