Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Sort, Lleida number of lottery winners. The municipality includes the small village of Olp. Sort, Lleida Sort is the capital of the "comarca" of Pallars Sobirà, in the province of Lleida, Catalonia, in the country of Spain. It is located at 692 metres above the sea, by the river Noguera Pallaresa, a tributary to the Segre. Population 2,113 (2005). It was once capital of the County of Pallars. The word "sort" is Catalan for "luck". The Sort-based lottery shop La Bruixa d'Or ("The Gold Witch") has taken advantage of the town's name to promote itself both within Spain (attracting business from around