Mydriasis eye, and also to reduce painful ciliary muscle spasm (see cycloplegia). One effect of administration of a mydriatic is intolerance to bright light (photophobia). Purposefully-induced mydriasis via mydriatics is also used as a diagnostic test for Horner's syndrome. Mydriasis can be induced via modulation of adrenergic or cholinergic signalling. Within the adrenergic system, norepinephrine is a hormone and neurotransmitter responsible for regulating physiological processes in the body, including the involuntary muscles of the autonomic nervous system (such as the dilation or constriction of the pupil aperture via the muscles of the iris). Modulation of norepinephrine signalling can induce mydriasis. For
Batman: The Widening Gyre release the remaining issues as a separate series to be called "Batman: Bellicosity", that was due in 2014, but to date, remains unreleased. In May 2009, it was announced that "Batman: The Widening Gyre" would be written by Kevin Smith and illustrated by Walt Flanagan. Months earlier, both had completed "". As Smith explained it, the series will have 12 issues split into two six-issue books. Book 1 was supposed to run from August 2009 to January 2010 and, after a six-month hiatus, Book 2 would run from July 2010 through December 2010. However, Book 1 was plagued by several