Background radiation equivalent time small area in India as high as 30 mSv (3 rem). Using the 2.4 mSv value each BRET unit equals 6.6 μSv. BRET values for diagnostic radiography procedures range from 2 BRET for a dental x-ray to around 400 for a barium enema study. Background radiation equivalent time Background Radiation Equivalent Time, or BRET, is a unit of measurement of ionizing radiation dosage. One BRET is the equivalent of one day worth of average human exposure to background radiation. The unit is also referred to as BERT (Background Equivalent Radiation Time). BRET units are used as a measure of low
Biological effects of radiation on the epigenome epigenetic up-regulation of genes. A similar mechanism involves the ataxia telangiectasia mutated (ATM) serine/threonine kinase which is an enzyme involved in the repair of double stranded breaks caused by ionizing radiation. ATM phosphorylates KAP1 which causes the heterochromatin to relax, allowing increased transcription to occur. The DNA mismatch repair gene (MSH2) promoter has shown a hypermethylation pattern when exposed to ionizing radiation. Reactive oxygen species induce the oxidization of deoxyguanosine into 8-hydroxydeoxyguanosine (8-OHdG) causing a change in chromatin structure. Gene promoters that contain 8-OHdG deactivate the chromatin by inducing trimethyl-H3K27 in the genome. Other enzymes such as transglutaminases (TGs) control