Toe the line 1813 publication had used the term "toe the mark" which had the same meaning as "toe the line's" modern usage, where the author wrote "He began to think it was high time to toe the mark." An 1828 publication also used "toe the plank" with a similar meaning. Over the years the term has been attributed to sports, including toeing the starting line in track events and toeing a center line in boxing, where boxers were instructed to line up on either side of to start a match. However, the earlier boxing term was "toeing the scratch", referring to a
Americans For Medical Advancement not,” and that the organization “explores the differences between the two.” What sets it apart is that it focuses “on the harm that is done to humans” and that animal protectionists are concerned about the harm done to animals. Americans for Medical Advancement targets their work to improve healthcare. The way the organization hopes to do so is by developing safer, more efficient techniques to use in labs. Since AFMA believes that animals do not give an accurate reading of how drugs will make a human react, the first step would be eliminating animal testing in the development of drugs