1793 Philadelphia yellow fever epidemic Philadelphia forced evacuation of certain neighborhoods and placed refugees in supervised camps. After the epidemic, the city inspected all houses and destroyed those it deemed unhealthy. American doctors did not identify the vector of yellow fever until the late nineteenth century. In 1881 Carlos Finlay, a Cuban doctor, argued that mosquito bites caused yellow fever; he credited Rush's published account of the 1793 epidemic for giving him the idea. He said that Rush had written: "Mosquitoes (the usual attendants of a sickly autumn) were uncommonly numerous..." In the late 1880s, Finlay's theories were confirmed in Cuba by experiments of the
Yellow fever vaccine group established in 2000 when a global shortage of yellow fever vaccine had developed because of the long lead time to manufacture the vaccine. As of 2013, there were four WHO-qualified manufacturers: Bio-Manguinhos in Brazil (with the Oswaldo Cruz Foundation), Institute Pasteur in Dakar, Senegal, the Federal State Unitary Enterprise of Chumakov Institute in Russia, and Sanofi Pasteur, the French pharmaceutical company. Two other manufacturers supply domestic markets: Wuhan Institute of Biological Products in China and Sanofi Pasteur in the United States. Seth Berkley, the chief executive of Gavi, has warned about the worldwide threat of yellow fever because of