Broad-spectrum antibiotic estimated 10-100 trillion multiple organisms that colonize the human body. As a side-effect of therapy, antibiotics can change the body's normal microbial content by attacking indiscriminately both the pathological and naturally occurring, beneficial or harmless bacteria found in the intestines, lungs and bladder. The destruction of the body's normal bacterial flora is thought to disrupt immunity, nutrition, and lead to a relative overgrowth in some bacteria or fungi. An overgrowth of drug-resistant microorganisms can lead to a secondary infection such as "Clostridium difficile" ("C. diff") or candidiasis ("thrush"). This side-effect is more likely with the use of broad-spectrum antibiotics, given
Gasteroid fungi described by Linnaeus in his original "Species Plantarum" of 1753, but the first critical treatment of the group was by Christiaan Hendrik Persoon in his "Synopsis methodica fungorum" of 1801. Until 1981, this book was the starting point for the naming of Gasteromycetes under the "International Code of Nomenclature for algae, fungi, and plants". Although the starting point was subsequently put back to 1753, names of gasteroid fungi used in Persoon's book are still sanctioned and cannot be replaced by earlier names. Elias Magnus Fries introduced the name Gasteromycetes for a class of fungi in his "Systema Mycologicum" of 1821,