Yellow fever In 1873, Shreveport, Louisiana lost 759 citizens in an 80-day period to a Yellow fever epidemic, with over 400 additional victims eventually succumbing. The total death toll from August through November was approximately 1,200, In 1878, about 20,000 people died in a widespread epidemic in the Mississippi River Valley. That year, Memphis had an unusually large amount of rain, which led to an increase in the mosquito population. The result was a huge epidemic of yellow fever. The steamship "John D. Porter" took people fleeing Memphis northward in hopes of escaping the disease, but passengers were not allowed to disembark
Yellow fever culture the virus and won a Nobel Prize in 1951 for this achievement. A French team developed the French neurotropic vaccine (FNV), which was extracted from mouse brain tissue. Since this vaccine was associated with a higher incidence of encephalitis, FNV was not recommended after 1961. Vaccine 17D is still in use, and more than 400 million doses have been distributed. Little research has been done to develop new vaccines. Some researchers worry that the 60-year-old technology for vaccine production may be too slow to stop a major new yellow-fever epidemic. Newer vaccines, based on vero cells, are in development