Yellow fever was the first illness shown to be transmissible by filtered human serum and transmitted by mosquitoes, by Walter Reed around 1900. The positive-sense, single-stranded RNA is around 11,000 nucleotides long and has a single open reading frame encoding a polyprotein. Host proteases cut this polyprotein into three structural (C, prM, E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the enumeration corresponds to the arrangement of the protein coding genes in the genome. Minimal yellow fever virus (YFV) 3'UTR region is required for stalling of the host 5'-3' exonuclease XRN1. The UTR contains PKS3 pseudoknot structure which
Yellow fever in Buenos Aires made of wood or clay and straw. In addition to the epidemic of yellow fever that we have mentioned, there were outbreaks of cholera in 1867 and 1868, which killed hundreds of people. On 27 January 1871, three cases of yellow fever were diagnosed in Buenos Aires. They were all in the San Telmo neighbourhood, which is full of tenements. From this date on, many more cases were registered, mostly in that neighbourhood. The doctors Tamini, Salvador Larrosa and Montes de Oca warned the City Commission of the outbreak of an epidemic. But the Commission, under the leadership of Narciso