Health threat from cosmic rays radiation resulting from particle interactions within the vitreous humor. This phenomenon has been replicated on Earth by scientists at various institutions. As the duration of the longest Apollo flights was less than two weeks, the astronauts had limited cumulative exposures and a corresponding low risk for radiation carcinogenesis. In addition, there were only 24 such astronauts, making statistical analysis of any potential health effects problematic. In the above discussion dose equivalents is units of Sievert (Sv) are noted, however the Sv is a unit for comparing cancer risks for different types of ionizing radiation. For CNS effects absorbed doses in
Biological effects of radiation on the epigenome epigenetic up-regulation of genes. A similar mechanism involves the ataxia telangiectasia mutated (ATM) serine/threonine kinase which is an enzyme involved in the repair of double stranded breaks caused by ionizing radiation. ATM phosphorylates KAP1 which causes the heterochromatin to relax, allowing increased transcription to occur. The DNA mismatch repair gene (MSH2) promoter has shown a hypermethylation pattern when exposed to ionizing radiation. Reactive oxygen species induce the oxidization of deoxyguanosine into 8-hydroxydeoxyguanosine (8-OHdG) causing a change in chromatin structure. Gene promoters that contain 8-OHdG deactivate the chromatin by inducing trimethyl-H3K27 in the genome. Other enzymes such as transglutaminases (TGs) control