Background radiation equivalent time BRET value corresponding to a dose of radiation is the number of days of average background dose it is equivalent to. It is calculated from the equivalent dose in sieverts by dividing by the average annual background radiation dose in Sv, and multiplying by 365: The definition of the BRET unit is apparently unstandardized, and depends on what value is used for the average annual background radiation dose, which varies greatly across time and location. The 2000 UNSCEAR estimate for worldwide average natural background radiation dose is 2.4 mSv (240 mrem), with a range from 1 to 13 mSv. A
Biological effects of radiation on the epigenome the normal development of the brain. DNA methylation influences tissue responses to ionizing radiation. Modulation of methylation in the gene MGMT or in transposable elements such as LINE1 could be used to alter tissue responses to ionizing radiation and potentially opening new areas for cancer treatment. MGMT serves as a prognostic marker in glioblastoma. Hypermethylation of MGMT is associated with the regression of tumors. Hypermethylation of MGMT silences its transcription inhibiting alkylating agents in tumor killing cells. Studies have shown patients who received radiotherapy, but no chemotherapy after tumor extraction, had an improved response to radiotherapy due to the methylation