Hypotonic hyponatremia dramatic increase the serum sodium concentration and place the patient at risk for so-called "central pontine myelinolysis" (CPM). That disorder is characterized by major neurologic damage, often of a permanent nature. Because of the risk of CPM, people with low volume hyponatremia may eventually require water infusion as well as volume replacement. Doing so lessens the chance of a too rapid increase of the serum sodium level as blood volume rises and ADH levels fall. In people who are volume depleted, i.e., their blood volume is too low, ADH secretion is increased, since volume depletion is a potent stimulus for
Human Element Robotoki was shut down on January 20, 2015 due to lack of publishing deal of the premium version of the game and the inability of the founder of the company to self-fund the development of the game. The game is currently on hiatus. Human Element Human Element was an online multiplayer video game under development by Robotoki for Microsoft Windows, PlayStation 4, and Xbox One. Development was halted when the studio was closed as indicated by a farewell message on Robotoki's (now defunct) blog on January 20, 2015, by the studio's founder, Robert Bowling. "Human Element" is the first game