Mydriasis eye, and also to reduce painful ciliary muscle spasm (see cycloplegia). One effect of administration of a mydriatic is intolerance to bright light (photophobia). Purposefully-induced mydriasis via mydriatics is also used as a diagnostic test for Horner's syndrome. Mydriasis can be induced via modulation of adrenergic or cholinergic signalling. Within the adrenergic system, norepinephrine is a hormone and neurotransmitter responsible for regulating physiological processes in the body, including the involuntary muscles of the autonomic nervous system (such as the dilation or constriction of the pupil aperture via the muscles of the iris). Modulation of norepinephrine signalling can induce mydriasis. For
What a Pushkin, what a son of a bitch! year: What a Pushkin, what a son of a bitch! "What a Pushkin, what a son of a bitch!" (; sometimes separated by exclamation mark instead of comma) is a catchphrase and winged word from Alexander Pushkin's correspondence with one of his friends, poet Pyotr Vyazemsky. The phrase commonly expresses a joy after finishing one's work and appears particularly in several Russian literary works. In a letter dated circa November 7 or beginning of October, 1825 Pushkin, celebrating his finished drama "Boris Godunov" wrote to Vyazemsky: That was preceded by what Pushkin wrote to Vyazemsky on July 13 of the