Brownian meander factor for the spatial axis must be square root of the scaling factor for the time axis. The process resulting from this snip-and-scale procedure is a Brownian meander. As the name suggests, it is a piece of Brownian motion that spends all its time away from its starting point formula_5. The transition density formula_12 of Brownian meander is described as follows: For formula_13 and formula_14, and writing we have and In particular, i.e. formula_19 has the Rayleigh distribution with parameter 1, the same distribution as formula_20, where formula_21 is an exponential random variable with parameter 1. Brownian meander In the
Brownian motion "x", 1 ≤ "i" ≤ "m", is given by ½Δ, where Δ is the Laplace–Beltrami operator given in local coordinates by where ["g"] = ["g"] in the sense of the inverse of a square matrix. The narrow escape problem is a ubiquitous problem in biology, biophysics and cellular biology which has the following formulation: a Brownian particle (ion, molecule, or protein) is confined to a bounded domain (a compartment or a cell) by a reflecting boundary, except for a small window through which it can escape. The narrow escape problem is that of calculating the mean escape time. This time