Yellow fever was the first illness shown to be transmissible by filtered human serum and transmitted by mosquitoes, by Walter Reed around 1900. The positive-sense, single-stranded RNA is around 11,000 nucleotides long and has a single open reading frame encoding a polyprotein. Host proteases cut this polyprotein into three structural (C, prM, E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the enumeration corresponds to the arrangement of the protein coding genes in the genome. Minimal yellow fever virus (YFV) 3'UTR region is required for stalling of the host 5'-3' exonuclease XRN1. The UTR contains PKS3 pseudoknot structure which
Yellow Fever Commission Yellow Fever Commission The Yellow Fever Commission was a research team of the United States Army which researched treatment for yellow fever. The research process itself became a focus of study for later generations. A United States nurse named Clara Maass and two Spanish immigrants were among those who died as a result of their research participation. Researchers mark the research of the Yellow Fever Commission as the origin of the model of modern consent in medical research. The 1934 play "Yellow Jack" told the story of Walter Reed in the Yellow Fever Commission. That play was the basis of