Venom organ failure. Many caterpillars have defensive venom glands associated with specialized bristles on the body, known as urticating hairs, which can be lethal to humans (e.g., that of the "Lonomia" moth), although the venom's strength varies depending on the species. Bees synthesize and employ an acidic venom (apitoxin) to cause pain in those that they sting to defend their hives and food stores, whereas wasps use a chemically different alkaline venom designed to paralyze prey, so it can be stored alive in the food chambers of their young. The use of venom is much more widespread than just these examples.
Venom optimization hypothesis and grasshoppers. Its venom glands store only about 10 μl of crude venom. Refilling of the glands takes 2–3 days and the lethal efficacy of the venom is, initially, very low for several days, requiring 8 to 18 days for full effect. It was found that the amount of venom released differed for each specific prey. For example, for bigger and stronger insects like beetles, the spider uses the entire amount of its venom; while for small ones, it uses only a small amount, thus economizing its costly venom. In fact, experiments show that the amount of venom released is