Diabetes in dogs preventor of the breakdown or catabolism of glycogen and fat. The absence of sufficient insulin causes this breaking-down process to be accelerated; it is the mechanism behind metabolizing fat instead of glucose and the appearance of ketones. Since the glucose that normally enters the cells is unable to do so without insulin, it begins to build up in the blood where it can be seen as hyperglycemia or high blood glucose levels. The tubules of the kidneys are normally able to re-absorb glucose, but they are unable to handle and process the amount of glucose they are being presented with.
Glucose major facilitator superfamily. In the small intestine (more precisely, in the jejunum), glucose is taken up into the intestinal epithelial cells with the help of glucose transporters via a secondary active transport mechanism called sodium ion-glucose symport via the sodium/glucose cotransporter 1. The further transfer occurs on the basolateral side of the intestinal epithelial cells via the glucose transporter GLUT2, as well as their uptake into liver cells, kidney cells, cells of the islets of Langerhans, nerve cells, astrocytes and tanyocytes. Glucose enters the liver via the vena portae and is stored there as a cellular glycogen. In the liver