Lixivaptan BALANCE study is a 650-patient Phase III, global, multi-center, randomized, placebo-controlled, double-blind, study of lixivaptan for hyponatremia in patients with heart failure. The primary objective is to evaluate the safety and effectiveness of lixivaptan, when compared to the placebo, in increasing serum sodium from baseline in heart failure patients with hyponatremia. In previous studies, lixivaptan improved blood sodium levels, lowered body weight and increased urine volume. Those studies suggest that lixivaptan may play an important role in treating hyponatremia and the signs and symptoms of water retention associated with heart failure, Syndrome of Inappropriate Anti-Diuretic Hormone(SIADH), and Liver Cirrhosis with
Autologous conditioned serum the procedure performed by Wehling, is one famous case based on his recovery from his previously poor knees.Some basketball fans refer to the procedure as the "Kobe Procedure". The procedure cost €6,000 (about $7,400) as of July 2012. The treatment is not covered by health insurance. Autologous conditioned serum Autologous conditioned serum, also known as Orthokine and Regenokine, is an experimental procedure in which a person's own blood is extracted, manipulated, and then reintroduced with claims benefit in osteoarthritis. There is limited evidence on safety and effectiveness as of 2017. It is not included in medical guidelines as of 2017.