Brownian motion on the discontinuous structure of matter". The direction of the force of atomic bombardment is constantly changing, and at different times the particle is hit more on one side than another, leading to the seemingly random nature of the motion. The many-body interactions that yield the Brownian pattern cannot be solved by a model accounting for every involved molecule. In consequence only probabilistic models applied to molecular populations can be employed to describe it. Two such models of the statistical mechanics, due to Einstein and Smoluchowski are presented below. Another, pure probabilistic class of models is the class of the
Brownian motion "x", 1 ≤ "i" ≤ "m", is given by ½Δ, where Δ is the Laplace–Beltrami operator given in local coordinates by where ["g"] = ["g"] in the sense of the inverse of a square matrix. The narrow escape problem is a ubiquitous problem in biology, biophysics and cellular biology which has the following formulation: a Brownian particle (ion, molecule, or protein) is confined to a bounded domain (a compartment or a cell) by a reflecting boundary, except for a small window through which it can escape. The narrow escape problem is that of calculating the mean escape time. This time