Honey bee as apitoxin, carries several active components, the most abundant of which is melittin, and the most biologically active are enzymes, particularly phospholipase A2. Bee venom is under laboratory and clinical research for its potential properties and uses in reducing risks for adverse events from bee venom therapy, rheumatoid arthritis, and use as an immunotherapy for protection against allergies from insect stings. Bee venom products are marketed in many countries, but, as of 2018, there are no approved clinical uses for these products which carry various warnings for potential allergic reactions. With an increased number of honey bees in a specific
Evolution of snake venom molecular history of snake venom have contradicted this, instead finding evidence of rapid adaptive evolution in many different clades, including the carpet vipers, "Echis", the ground rattlesnakes, "Sistrurus", and the Malayan pit viper, as well as generally in the diversification of PLA2 proteins. There is phylogenetic evidence of positive selection and rapid rates of gene gain and loss in venom genes of "Sistrurus" taxa feeding on different prey. Several studies have found evidence that venom and resistance to venom in prey species have evolved in a coevolutionary arms race. For example, wood rats of the genus "Neotoma" have a high