Broad-spectrum antibiotic estimated 10-100 trillion multiple organisms that colonize the human body. As a side-effect of therapy, antibiotics can change the body's normal microbial content by attacking indiscriminately both the pathological and naturally occurring, beneficial or harmless bacteria found in the intestines, lungs and bladder. The destruction of the body's normal bacterial flora is thought to disrupt immunity, nutrition, and lead to a relative overgrowth in some bacteria or fungi. An overgrowth of drug-resistant microorganisms can lead to a secondary infection such as "Clostridium difficile" ("C. diff") or candidiasis ("thrush"). This side-effect is more likely with the use of broad-spectrum antibiotics, given
Cavalier-Smith's system of classification to plants. By 1959, Robert Harding Whittaker (1920–1980) proposed that fungi, which were formerly classified as plants, be given their own kingdom. His four kingdoms of life were: Whittaker subdivided the Protista into two subkingdoms: Bacteria are fundamentally different from the eukaryotes (plants, animals, fungi, amebas, protozoa, and chromista). Eukaryotes have cell nuclei, bacteria do not. In 1969, Robert Whittaker elevated the bacteria to the status of kingdom. His new classification system divided the living world into five kingdoms: The kingdom Monera can be divided into two distinct groups: eubacteria and archaebacteria. In 1977 Carl Woese and George E. Fox