Lixivaptan BALANCE study is a 650-patient Phase III, global, multi-center, randomized, placebo-controlled, double-blind, study of lixivaptan for hyponatremia in patients with heart failure. The primary objective is to evaluate the safety and effectiveness of lixivaptan, when compared to the placebo, in increasing serum sodium from baseline in heart failure patients with hyponatremia. In previous studies, lixivaptan improved blood sodium levels, lowered body weight and increased urine volume. Those studies suggest that lixivaptan may play an important role in treating hyponatremia and the signs and symptoms of water retention associated with heart failure, Syndrome of Inappropriate Anti-Diuretic Hormone(SIADH), and Liver Cirrhosis with
Blood libel Blood libel Blood libel (also blood accusation) is an antisemitic canard accusing Jews of kidnapping and murdering the children of Christians in order to use their blood as part of religious rituals. Historically, these claims—alongside those of well poisoning and host desecration—have been a major theme of the persecution of Jews in Europe. Blood libels typically say that Jews require human blood for the baking of matzos for Passover, although this element was allegedly absent in the earliest cases which claimed that then-contemporary Jews reenacted the crucifixion. The accusations often assert that the blood of the children of Christians is