Apamin therapeutic effect on Parkinson's disease. Dopamine, which is depleted in this disease, will be released from midbrain dopaminergic neurons when these SK channels are inhibited. SK channels have also been proposed as targets for the treatment of epilepsy, emotional disorders and schizophrenia. Apamin Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca-activated K channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, these are cysteine, lysine, arginine, arginine and histidine. These amino
Spaghetti sort parallel computing device. There are then "n" rods to remove so, assuming each contact-and-removal operation takes constant time, the worst-case time complexity of the algorithm is O("n"). Spaghetti sort Spaghetti sort is a linear-time, analog algorithm for sorting a sequence of items, introduced by Alexander Dewdney in his "Scientific American" column. This algorithm sorts a sequence of items requiring O("n") stack space in a stable manner. It requires a parallel processor. For simplicity, assume we are sorting a list of natural numbers. The sorting method is illustrated using uncooked rods of spaghetti: Preparing the "n" rods of spaghetti takes linear