Glucose uptake of hepatocytes and pancreatic beta cells (in mice, but GLUT1 in human beta cells; see Reference 1). The high Km of GLUT2 allows for glucose sensing; rate of glucose entry is proportional to blood glucose levels. GLUT4 transporters are insulin sensitive, and are found in muscle and adipose tissue. As muscle is a principal storage site for glucose and adipose tissue for triglyceride (into which glucose can be converted for storage), GLUT4 is important in post-prandial uptake of excess glucose from the bloodstream. Moreover, several recent papers show that GLUT 4 is present in the brain also. The drug metformin
Absorptive state Absorptive state Absorptive state is the period in which the gastrointestinal tract is full and the anabolic processes exceed catabolism. The fuel used for this process is glucose. Carbohydrates - Simple sugars are sent to the liver where they are converted to glucose. The glucose then travels to the blood or is converted to glycogen and fat (triglyceride). The glycogen and fat will be stored in the liver and adipose tissue, respectively, as reserves for the post-absorptive state. The remaining glucose is taken in for use by body cells or stored in skeletal muscle as glycogen. Triglycerides - Chylomicrons, the