Irvine Welsh His first novel, "Trainspotting", was published in 1993. Set in the mid-1980s, it uses a series of loosely connected short stories to tell the story of a group of characters tied together by decaying friendships, heroin addiction and stabs at escape from the oppressive boredom and brutality of their lives in the housing schemes. It was released to shock and outrage in some circles and great acclaim in others; "Time Out" called it "funny, unflinchingly abrasive, authentic and inventive", and "The Sunday Times" called Welsh "the best thing that has happened to British writing for decades". It was adapted as
Heroin Regulations", and the "Food and Drug Regulations", to allow doctors to prescribe diamorphine to people who have a severe opioid addiction who have not responded to other treatments. The prescription heroin can be accessed by doctors through Health Canada's Special Access Programme (SAP) for "emergency access to drugs for patients with serious or life-threatening conditions when conventional treatments have failed, are unsuitable, or are unavailable." The onset of heroin's effects depends upon the route of administration. Studies have shown that the subjective pleasure of drug use (the reinforcing component of addiction) is proportional to the rate at which the blood