Laudanum his "archanum" or "laudanum", may or may not have contained opium. Paracelsus' laudanum was strikingly different from the standard laudanum of the 17th century and beyond, containing crushed pearls, musk, amber, and other substances. One researcher has documented that "Laudanum, as listed in the "London Pharmacopoeia" (1618), was a pill made from opium, saffron, castor, ambergris, musk and nutmeg". Laudanum remained largely unknown until the 1660s when English physician Thomas Sydenham (1624–1689) compounded a proprietary opium tincture that he also named laudanum, although it differed substantially from the laudanum of Paracelsus. In 1676 Sydenham published a seminal work, "Medical Observations
Partnership for Drug-Free Kids these stories at times in its commercials. For example, a 28-year-old former drug user met for lunch with the Partnership's Doria Steedman, and at one point "pulled out her [false] teeth" to show the ravages of the drug use; this idea was used in a subsequent commercial. At the same time, different drugs were coming in and out of vogue, sometimes introduced by films such as "Trainspotting". In 1994, an independent assessment from the Johns Hopkins School of Medicine suggested that the anti-drug campaign was having a measurable "deterrence effect" on American adolescents: Research efforts suggested that a key metric