Nail polish can be harsh on skin and nails. Acetone can also remove artificial nails made of acrylic or cured gel. A less harsh nail polish remover is ethyl acetate, which often also contains isopropyl alcohol. Ethyl acetate is usually the original solvent for nail polish itself. Acetonitrile has been used as a nail polish remover, but it is more toxic and potentially more carcinogenic than the aforementioned options. It has been banned in the European Economic Area for use in cosmetics since 17 March 2000. The health risks associated with nail polish are disputed. According to the U.S. Department of Health
SH-053-R-CH3-2′F SH-053-R-CH3-2′F SH-053-R-CH3-2′F is a drug used in scientific research which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more subtype-selective than most other drugs of this class, having high selectivity, binding affinity and efficacy at the α subtype of the GABA receptor. This gives much tighter control of the effects produced, and so while SH-053-R-CH3-2′F retains sedative and anxiolytic effects, it does not cause ataxia at moderate doses. SH-053-R-CH3-2′F also blocks the nootropic effects of the α-selective inverse agonist PWZ-029, so amnesia is also a likely side effect. Replacement of the