Trifluoroacetic acid Trifluoroacetic acid Trifluoroacetic acid (TFA) is an organofluorine compound with the chemical formula CFCOH. It is a structural analogue of acetic acid with all three of the acetyl group’s hydrogen atoms replaced by fluorine atoms and is a colorless liquid with a vinegar like odor. TFA is a stronger acid than acetic acid, having an acid ionisation constant that is approximately 34,000 times higher, as the highly electronegative fluorine atoms and consequent electron-withdrawing nature of the trifluoromethyl group weakens the oxygen-hydrogen bond (allowing for greater acidity) and stabilises the anionic conjugate base. TFA is widely used in organic chemistry for
Phosphomolybdic acid organic synthesis. It has been shown to be a good catalyst for the Skraup reaction for the synthesis of substituted quinolines. Phosphomolybdic acid Phosphomolybdic acid, also known as dodeca molybdophosphoric acid or PMA, is a yellow-green chemical compound that freely soluble in water and polar organic solvents such as ethanol. It is used as a stain in histology and in organic synthesis Phosphomolybdic acid is a component of Masson's trichrome stain. Phosphomolybdic is used as a stain for developing thin-layer chromatography plates, staining phenolics, hydrocarbon waxes, alkaloids, and steroids. Conjugated unsaturated compounds reduce PMA to molybdenum blue. The color intensifies