2010 Quick-Step season entered the Tour of Qatar with two-time defending champion Boonen leading their squad. Boonen won two stages in the race, but a two-man breakaway in the race's second stage proved critical, as it afforded Wouter Mol and Geert Steurs the top two steps on the podium by more than a minute over the rest of the field. Boonen finished third overall. Quick Step came to the Giro with a squad headed by Cataldo. Seeldraeyers, who had won the youth classification in the 2009 Giro d'Italia, was kept off the squad in favor of the Tour de France. Weylandt was included
2011 Quick-Step season earlier in the race, but thanks to the efforts of Van Impe, he was able to chase back on. Despite Boonen's intentions of hindering the chase, the break was caught, with 's Ian Stannard the last man brought back. Steegmans began performing a leadout when Stannard was caught, and Boonen reacted essentially on instinct to sprint for the win. He came first, ahead of Daniele Bennati and Tyler Farrar, a result which surprised him given that he has not targeted Gent–Wevelgem in recent seasons. The result moved Quick Step from 18th (last) place up to 14th in the UCI standings.