Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Old Crow Medicine Show multiple times at other major festivals, e.g., Bonnaroo Music Festival, MerleFest, Telluride Bluegrass Festival, Hardly Strictly Bluegrass Festival, and Newport Folk Festival. They have made frequent guest appearances on "A Prairie Home Companion" with Garrison Keillor. The group received the 2013 Trailblazer Award from the Americana Music Association, performing at the Americana Honors & Awards Show. Publishing administrator Downtown Music Publishing represents the works of Old Crow Medicine Show. Ketch Secor and Critter Fuqua first met in the seventh grade in Harrisonburg, Virginia and began playing music together. They performed open mics at the Little Grill diner, as did Robert