Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Ozone depletion to increase dramatically as a result of thinning ozone, as well as harming plants and animals. These concerns led to the adoption of the Montreal Protocol in 1987, which bans the production of CFCs, halons and other ozone-depleting chemicals. The ban came into effect in 1989. Ozone levels stabilized by the mid-1990s and began to recover in the 2000s. Recovery is projected to continue over the next century, and the ozone hole is expected to reach pre-1980 levels by around 2075. The Montreal Protocol is considered the most successful international environmental agreement to date. Three forms (or allotropes) of oxygen