Marcellus natural gas trend Experts believe that these were induced seismicity triggered by disposal of wastewater from Marcellus gas wells into Class II underground injection wells. The Ohio Department of Natural Resources Ohio Seismic Network (OhioSeis) determined that the 2011 earthquakes are distinct from previous seismic activity in the region because of their proximity to the Northstar 1, a Class II deep injection well. All of the earthquakes were clustered less than a mile around the well. ODNR then ordered the company to shut down operations and plug the well. ODNR has continued to report increased seismic activity through 2017 in eastern Ohio in
Therapeutic effect strategy or agent. To maximize therapeutic effects (desired) and minimize side effects (undesired) requires recognition and quantification of the treatment in multiple dimensions. In the specific case of targeted pharmaceutical interventions a combination of therapies is often needed to achieve the desired results. Therapeutic effect Therapeutic effect refers to the responses(s) after a treatment of any kind, the results of which are judged to be useful or favorable. This is true whether the result was expected, unexpected, or even an unintended consequence. An adverse effect (including nocebo) is the converse and refers to harmful or undesired responses(s). What constitutes a