Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Partnership for Drug-Free Kids these stories at times in its commercials. For example, a 28-year-old former drug user met for lunch with the Partnership's Doria Steedman, and at one point "pulled out her [false] teeth" to show the ravages of the drug use; this idea was used in a subsequent commercial. At the same time, different drugs were coming in and out of vogue, sometimes introduced by films such as "Trainspotting". In 1994, an independent assessment from the Johns Hopkins School of Medicine suggested that the anti-drug campaign was having a measurable "deterrence effect" on American adolescents: Research efforts suggested that a key metric