Blood type diet type diet hypothesis and no clinical evidence that it improves health. Peter J. D'Adamo, a naturopath, is the most prominent proponent of blood type diets. Luiz C. de Mattos and Haroldo W. Moreira point out that assertions made by proponents of blood type diets that the O blood type was the first human blood type requires that the O gene have evolved before the A and B genes in the ABO locus; phylogenetic networks of human and non-human ABO alleles show that the A gene was the first to evolve. They argue that it would be extraordinary, from the perspective
Blood type "null") in other languages. The Rh system (Rh meaning "Rhesus") is the second most significant blood-group system in human-blood transfusion with currently 50 antigens. The most significant Rh antigen is the D antigen, because it is the most likely to provoke an immune system response of the five main Rh antigens. It is common for D-negative individuals not to have any anti-D IgG or IgM antibodies, because anti-D antibodies are not usually produced by sensitization against environmental substances. However, D-negative individuals can produce IgG anti-D antibodies following a sensitizing event: possibly a fetomaternal transfusion of blood from a fetus in