Acid–base reaction models as theories that complement each other. For example the current Lewis model has the broadest definition of what an acid and base are, with the Bronsted-Lowry theory being a subset of what acids and bases are, and the Arrhenius theory being the most restrictive. The first scientific concept of acids and bases was provided by Lavoisier in around 1776. Since Lavoisier's knowledge of strong acids was mainly restricted to oxoacids, such as (nitric acid) and (sulfuric acid), which tend to contain central atoms in high oxidation states surrounded by oxygen, and since he was not aware of the true
Methylmalonic acid Methylmalonic acid Methylmalonic acid (MMA) (conjugate base methylmalonate) is a dicarboxylic acid that is a "C"-methylated derivative of malonate. The coenzyme A linked form of methylmalonic acid, methylmalonyl-CoA, is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B as a cofactor. In this way, it enters the Krebs cycle, and is thus part of one of the anaplerotic reactions. Increased methylmalonic acid levels may indicate a vitamin B deficiency. However, it is sensitive (those with the disease almost always test positive) but not specific (those that do not have the disease do not always test negative).