Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Aarhus Protocol on Persistent Organic Pollutants housed 53 different country members and alliance. The protocol was amended on 18 December 2009, but the amended version has not yet come into force. As of May 2013, the protocol has been ratified by 31 states and the European Union. In the United States, the protocol is an executive agreement that does not require Senate approval. However, legislation is needed to resolve inconsistencies between provisions of the protocol and existing U.S. laws (specifically the Toxic Substances Control Act and the Federal Insecticide, Fungicide, and Rodenticide Act). The following substances are contained in the CLRTAP POPs Protocol. The document focuses