Acetonitrile formulations for nail polish remover, despite its toxicity. At least two cases have been reported of accidental poisoning of young children by acetonitrile-based nail polish remover, one of which was fatal. Acetone and ethyl acetate are often preferred as safer for domestic use, and acetonitrile has been banned in cosmetic products in the European Economic Area since March 2000. In common with other nitriles, acetonitrile can be metabolised in microsomes, especially in the liver, to produce hydrogen cyanide, as was first shown by Pozzani "et al." in 1959. The first step in this pathway is the oxidation of acetonitrile to
Vamp Nail Polish bottle and sold extremely well, with nationwide shortages for months after its introduction. It became Chanel's best selling product. By 1996 "Newsweek" was reporting that the color was "finally out of style," but even into 2000, it was the fifth best-selling nail polish in the world. Before Chanel introduced Vamp, dark, non-traditional polish colors were shunned by mainstream cosmetics companies and their customers. Vamp was responsible for setting "in motion a widespread trend that made nail polish in virtually any color acceptable." According to Melinda Davis, the "extraordinary phenomenon of Vamp" was the "fons et origo" of a late twentieth