Seismic retrofit Seismic retrofit Seismic retrofitting is the modification of existing structures to make them more resistant to seismic activity, ground motion, or soil failure due to earthquakes. With better understanding of seismic demand on structures and with our recent experiences with large earthquakes near urban centers, the need of seismic retrofitting is well acknowledged. Prior to the introduction of modern seismic codes in the late 1960s for developed countries (US, Japan etc.) and late 1970s for many other parts of the world (Turkey, China etc.), many structures were designed without adequate detailing and reinforcement for seismic protection. In view of the
Therapeutic effect strategy or agent. To maximize therapeutic effects (desired) and minimize side effects (undesired) requires recognition and quantification of the treatment in multiple dimensions. In the specific case of targeted pharmaceutical interventions a combination of therapies is often needed to achieve the desired results. Therapeutic effect Therapeutic effect refers to the responses(s) after a treatment of any kind, the results of which are judged to be useful or favorable. This is true whether the result was expected, unexpected, or even an unintended consequence. An adverse effect (including nocebo) is the converse and refers to harmful or undesired responses(s). What constitutes a