Seismic code of buildings which survived the earthquake motion, recommended that the seismic ratio (seismic acceleration divided by the gravity acceleration) equal to 1/12 for the first floor and 1/8 for the floors above should be used in seismic design of buildings. The Committee proposed equivalent vertical forces much larger than the horizontal forces because vertical motion acted as impacts. This is believed to be the first known quantitative recommendation of design seismic forces in the history of seismic codes. The recommendation was adopted in Royal Decree No. 573 of April 29, 1915. The height of the buildings was limited to two
Natural product and therefore natural products are often used as starting points for drug discovery. Natural product constituents have inspired numerous drug discovery efforts that eventually gained approval as new drugs by the U.S. Food and Drug Administration Indigenous peoples and ancient civilizations experimented with various plant and animal parts to determine what effect they might have. Through trial and error in isolated cases, traditional healers or shamans found some sources to provide therapeutic effect, representing knowledge of a crude drug that was passed down through generations in such practices as traditional Chinese medicine and Ayurveda. Extracts of some natural products led