Marcellus natural gas trend Experts believe that these were induced seismicity triggered by disposal of wastewater from Marcellus gas wells into Class II underground injection wells. The Ohio Department of Natural Resources Ohio Seismic Network (OhioSeis) determined that the 2011 earthquakes are distinct from previous seismic activity in the region because of their proximity to the Northstar 1, a Class II deep injection well. All of the earthquakes were clustered less than a mile around the well. ODNR then ordered the company to shut down operations and plug the well. ODNR has continued to report increased seismic activity through 2017 in eastern Ohio in
Natural product and therefore natural products are often used as starting points for drug discovery. Natural product constituents have inspired numerous drug discovery efforts that eventually gained approval as new drugs by the U.S. Food and Drug Administration Indigenous peoples and ancient civilizations experimented with various plant and animal parts to determine what effect they might have. Through trial and error in isolated cases, traditional healers or shamans found some sources to provide therapeutic effect, representing knowledge of a crude drug that was passed down through generations in such practices as traditional Chinese medicine and Ayurveda. Extracts of some natural products led