Eye color for a plausible argument stating that some eyes can or do change, based on chemical reactions and hormonal changes within the body. Studies on Caucasian twins, both fraternal and identical, have shown that eye color over time can be subject to change, and major demelanization of the iris may also be genetically determined. Most eye-color changes have been observed or reported in the Caucasian population with hazel and amber eyes. Carleton Coon created a chart by the original Martin scale. The numbering is reversed on the scale below in the (later) Martin–Schultz scale, which is (still) used in physical anthropology.
Albinism in humans due to genetic factors. These include notably the Native American Kuna, Zuni and Hopi nations (respectively of Panama, New Mexico and Arizona); Japan, in which one particular form of albinism is unusually common; and Ukerewe Island, the population of which shows a very high incidence of albinism. In physical terms, humans with albinism commonly have visual problems and need sun protection. Humans with albinism often face social and cultural challenges (even threats), as the condition is often a source of ridicule, discrimination, or even fear and violence. It is especially socially stigmatised in many African societies. A study conducted in