Acetonitrile formulations for nail polish remover, despite its toxicity. At least two cases have been reported of accidental poisoning of young children by acetonitrile-based nail polish remover, one of which was fatal. Acetone and ethyl acetate are often preferred as safer for domestic use, and acetonitrile has been banned in cosmetic products in the European Economic Area since March 2000. In common with other nitriles, acetonitrile can be metabolised in microsomes, especially in the liver, to produce hydrogen cyanide, as was first shown by Pozzani "et al." in 1959. The first step in this pathway is the oxidation of acetonitrile to
Nail polish either makeup or nail coloring, since natural appearances were considered more chaste and pure. In the 1920s, however, women left corsets and long gowns behind, changed to simple loose-fitting dresses, and began to wear color in new makeups and nail products, partly in rebellion to such prim customs of their recent past. Since the 1920s, nail colors progressed from French manicures and standard reds to various palettes of color choices, usually coordinated with the fashion industry's clothing colors for the season. By the 1940's the whole nail is finally painted as before it was fashionable to have the tips bare