Trifluoroacetic acid Trifluoroacetic acid Trifluoroacetic acid (TFA) is an organofluorine compound with the chemical formula CFCOH. It is a structural analogue of acetic acid with all three of the acetyl group’s hydrogen atoms replaced by fluorine atoms and is a colorless liquid with a vinegar like odor. TFA is a stronger acid than acetic acid, having an acid ionisation constant that is approximately 34,000 times higher, as the highly electronegative fluorine atoms and consequent electron-withdrawing nature of the trifluoromethyl group weakens the oxygen-hydrogen bond (allowing for greater acidity) and stabilises the anionic conjugate base. TFA is widely used in organic chemistry for
Beta-Hydroxybutyric acid Beta-Hydroxybutyric acid β-Hydroxybutyric acid, also known as (R)-3-hydroxybutyric acid, is an organic compound and a beta hydroxy acid with the chemical formula CHCH(OH)CHCOH; its conjugate base is β-hydroxybutyrate, also known as 3-hydroxybutyrate. β-Hydroxybutyric acid is a chiral compound with two enantiomers: -β-hydroxybutyric acid and -β-hydroxybutyric acid. Its oxidized and polymeric derivatives occur widely in nature. In humans, -β-hydroxybutyric acid is one of two primary endogenous agonists of hydroxycarboxylic acid receptor 2 (HCA), a G protein-coupled receptor (GPCR). In humans, can be synthesized in the liver via the metabolism of fatty acids (e.g., butyrate), , and ketogenic amino acids through a