Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Separation of concerns 1989, Chris Reade wrote a book titled "Elements of Functional Programming" that describes separation of concerns: Reade continues to say, Separation of concerns is crucial to the design of the Internet. In the Internet Protocol Suite, great efforts have been made to separate concerns into well-defined layers. This allows protocol designers to focus on the concerns in one layer, and ignore the other layers. The Application Layer protocol SMTP, for example, is concerned about all the details of conducting an email session over a reliable transport service (usually TCP), but not in the least concerned about how the transport service