Seismic gap have occurred in previously-identified seismic gaps. Prior to the 1989 Loma Prieta earthquake, that segment of the San Andreas fault system recorded much less seismic activity than other parts of the fault. The main shock and aftershocks of the 1989 event occurred within the previous seismic gap. Immediately following the 2004 Indian Ocean earthquake, a seismic gap analysis of the seismic zones around the Pacific Ocean identified the Central Kuril segment of the Kuril-Kamchatka Trench subduction zone as the most likely to give rise to a major earthquake. This zone, 500 km in length, at that time had experienced no
Therapeutic effect strategy or agent. To maximize therapeutic effects (desired) and minimize side effects (undesired) requires recognition and quantification of the treatment in multiple dimensions. In the specific case of targeted pharmaceutical interventions a combination of therapies is often needed to achieve the desired results. Therapeutic effect Therapeutic effect refers to the responses(s) after a treatment of any kind, the results of which are judged to be useful or favorable. This is true whether the result was expected, unexpected, or even an unintended consequence. An adverse effect (including nocebo) is the converse and refers to harmful or undesired responses(s). What constitutes a