Seismic gap have occurred in previously-identified seismic gaps. Prior to the 1989 Loma Prieta earthquake, that segment of the San Andreas fault system recorded much less seismic activity than other parts of the fault. The main shock and aftershocks of the 1989 event occurred within the previous seismic gap. Immediately following the 2004 Indian Ocean earthquake, a seismic gap analysis of the seismic zones around the Pacific Ocean identified the Central Kuril segment of the Kuril-Kamchatka Trench subduction zone as the most likely to give rise to a major earthquake. This zone, 500 km in length, at that time had experienced no
Natural product and therefore natural products are often used as starting points for drug discovery. Natural product constituents have inspired numerous drug discovery efforts that eventually gained approval as new drugs by the U.S. Food and Drug Administration Indigenous peoples and ancient civilizations experimented with various plant and animal parts to determine what effect they might have. Through trial and error in isolated cases, traditional healers or shamans found some sources to provide therapeutic effect, representing knowledge of a crude drug that was passed down through generations in such practices as traditional Chinese medicine and Ayurveda. Extracts of some natural products led