Transverse nasal crease Transverse nasal crease The transverse nasal crease or groove is a usually white line between the upper two-thirds and the lower third of the human nose (slightly above the cartilage tip between the bridge and nostrils). It can occur as the result of heredity, accident, or the constant rubbing or wiping of the nose, commonly referred to as the allergic salute. In addition to cases caused by heredity, physical injury, the transverse nasal crease is common in children and adults with chronic nasal allergies. People with allergies often use their hands to remove mucus from a runny nose or rub
Nasal administration Nasal administration Nasal administration is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. Nasal sprays are locally acting drugs such as decongestants for cold and allergy treatment, whose systemic effects are usually minimal. Examples of systemically active drugs available as nasal sprays are migraine drugs, nicotine replacement, and hormone treatments. The nasal cavity is covered by a thin mucosa which is well vascularised. Therefore, a drug molecule