Acid–base reaction models as theories that complement each other. For example the current Lewis model has the broadest definition of what an acid and base are, with the Bronsted-Lowry theory being a subset of what acids and bases are, and the Arrhenius theory being the most restrictive. The first scientific concept of acids and bases was provided by Lavoisier in around 1776. Since Lavoisier's knowledge of strong acids was mainly restricted to oxoacids, such as (nitric acid) and (sulfuric acid), which tend to contain central atoms in high oxidation states surrounded by oxygen, and since he was not aware of the true
Acid-base extraction Acid-base extraction Acid-base extraction is a procedure using sequential liquid–liquid extractions to purify acids and bases from mixtures based on their chemical properties. Acid-base extraction is routinely performed during the work-up after chemical syntheses and for the isolation of compounds and natural products like alkaloids from crude extracts. The product is largely free of neutral and acidic or basic impurities. It is not possible to separate chemically similar acids or bases using this simple method. The fundamental theory behind this technique is that salts, which are ionic, tend to be water-soluble while neutral molecules tend not to be. The addition