Seismic retrofit imminent problem, various research work has been carried out. State-of-the-art technical guidelines for seismic assessment, retrofit and rehabilitation have been published around the world – such as the ASCE-SEI 41 and the New Zealand Society for Earthquake Engineering (NZSEE)'s guidelines. These codes must be regularly updated; the 1994 Northridge earthquake brought to light the brittleness of welded steel frames, for example. The retrofit techniques outlined here are also applicable for other natural hazards such as tropical cyclones, tornadoes, and severe winds from thunderstorms. Whilst current practice of seismic retrofitting is predominantly concerned with structural improvements to reduce the seismic hazard
Therapeutic effect strategy or agent. To maximize therapeutic effects (desired) and minimize side effects (undesired) requires recognition and quantification of the treatment in multiple dimensions. In the specific case of targeted pharmaceutical interventions a combination of therapies is often needed to achieve the desired results. Therapeutic effect Therapeutic effect refers to the responses(s) after a treatment of any kind, the results of which are judged to be useful or favorable. This is true whether the result was expected, unexpected, or even an unintended consequence. An adverse effect (including nocebo) is the converse and refers to harmful or undesired responses(s). What constitutes a