Internal combustion engine the atmosphere by the reaction of and volatile organic compounds in the presence of sunlight. Ground-level ozone is harmful to human health and the environment. Though the same chemical substance, ground-level ozone should not be confused with stratospheric ozone, or the ozone layer, which protects the earth from harmful ultraviolet rays. Carbon fuels contain sulfur and impurities that eventually produce sulfur monoxides (SO) and sulfur dioxide (SO) in the exhaust, which promotes acid rain. In the United States, nitrogen oxides, PM, carbon monoxide, sulphur dioxide, and ozone, are regulated as criteria air pollutants under the Clean Air Act to levels
Sulfur dioxide are mediated via ATP-dependent calcium channels and L-type ("dihydropyridine") calcium channels. Endogenous sulfur dioxide is also a potent antiinflammatory, antioxidant and cytoprotective agent. It lowers blood pressure and slows hypertensive remodeling of blood vessels, especially thickening of their intima. It also regulates lipid metabolism. Endogenous sulfur dioxide also diminishes myocardial damage, caused by isoproterenol adrenergic hyperstimulation, and strengthens the myocardial antioxidant defense reserve. Being easily condensed and possessing a high heat of evaporation, sulfur dioxide is a candidate material for refrigerants. Prior to the development of chlorofluorocarbons, sulfur dioxide was used as a refrigerant in home refrigerators. Sulfur dioxide is