Bromochloromethane such as halon 1211 and 1301 were developed. Due to its ozone depletion potential its production was banned from January 1, 2002, at the "Eleventh Meeting of the Parties for the Montreal Protocol on Substances that Deplete the Ozone Layer". It can be biologically decomposed using the hydrolase enzyme alkylhalidase by the reaction: In the "Enter the Matrix" video game, the player can find a "Chloro-Bromo Methane Gun", which is used as a fire extinguisher. It fires a pressurized cartridge of CBM gas to put out fires. However, due to its chemical properties, firing a cartridge near people causes their
Wiley protocol at separate times throughout the period. The protocol is promoted as differing from conventional hormone replacement therapy in several ways: The protocol also includes a follow-up program to monitor the serum of the bioidentical hormones. Wiley has stated that in her opinion, the most important aspect of the protocol is the specific schedule and levels of the hormone doses rather than their bioidentical nature. A patent was granted for the protocol in 2011 for the specific blend of hormones and dosing method. Concerns have been raised that serum levels may not be an acceptable marker for transdermally administered hormones, that