Acetonitrile formulations for nail polish remover, despite its toxicity. At least two cases have been reported of accidental poisoning of young children by acetonitrile-based nail polish remover, one of which was fatal. Acetone and ethyl acetate are often preferred as safer for domestic use, and acetonitrile has been banned in cosmetic products in the European Economic Area since March 2000. In common with other nitriles, acetonitrile can be metabolised in microsomes, especially in the liver, to produce hydrogen cyanide, as was first shown by Pozzani "et al." in 1959. The first step in this pathway is the oxidation of acetonitrile to
Staple remover fragile papers. Proper use of the opposing wedge staple remover is debated; the two major methods are described below. The user forcefully clips the front flat side of the staple, causing the folded tabs on the reverse side to open and pull through the entry holes. This method requires much less time. Although this method is quick, it can have the undesirable side effect of tearing the paper when the folded tabs pull through. Tearing usually does not occur when higher quality paper is used or the staple connects three or more sheets. The inventor of the original staple remover,