Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Exercise is Medicine national institution (an academic institution, health organization, or other non-profit organization) under the direction of a National Center Director, acting on behalf of the National Center Advisory Board. EIM National Centers have been formally established in the following countries: Exercise is Medicine Exercise is Medicine® (EIM) is a nonprofit initiative co-launched by the American College of Sports Medicine (ACSM) and the American Medical Association (AMA), with support from the Office of the Surgeon General and the 18th Surgeon General Regina Benjamin, on November 5, 2007. The Exercise is Medicine (EIM) initiative calls for physical activity to be included as a