Acid–base reaction models as theories that complement each other. For example the current Lewis model has the broadest definition of what an acid and base are, with the Bronsted-Lowry theory being a subset of what acids and bases are, and the Arrhenius theory being the most restrictive. The first scientific concept of acids and bases was provided by Lavoisier in around 1776. Since Lavoisier's knowledge of strong acids was mainly restricted to oxoacids, such as (nitric acid) and (sulfuric acid), which tend to contain central atoms in high oxidation states surrounded by oxygen, and since he was not aware of the true
Acetoacetic acid widely used in the production of arylide yellows and diarylide dyes. Although the esters can be used in this reaction, diketene also reacts with alcohols and amines to the corresponding acetoacetic acid derivatives in a process called acetoacetylation. An example is the reaction with 2-aminoindane: Acetoacetic acid is measured in the urine of people with diabetes to test for ketoacidosis and for monitoring people on a ketogenic or low-carbohydrate diet, This is done using dipsticks coated in nitroprusside or similar reagents. Nitroprusside changes from pink to purple in the presence of acetoacetate, the conjugate base of acetoacetic acid, and the