Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Pennsylvania Department of Drug and Alcohol Programs has been proven successful to those trying to remedy their addictions. DDAP provides access to programs such as the prescription drug take back program, overdose awareness, and information on rehab centers. One of their main projects, is to spread the knowledge and availability of Naloxone, which is a medication that can reverse an overdose caused by an Opioid drug overdose. They have made progress on this front by enacting ACT 139, which gives first responders, friends, and families access to the opioid overdose reversal medicine, this way more lives can be saved by a quicker treatment response. Within the United