Acetonitrile formulations for nail polish remover, despite its toxicity. At least two cases have been reported of accidental poisoning of young children by acetonitrile-based nail polish remover, one of which was fatal. Acetone and ethyl acetate are often preferred as safer for domestic use, and acetonitrile has been banned in cosmetic products in the European Economic Area since March 2000. In common with other nitriles, acetonitrile can be metabolised in microsomes, especially in the liver, to produce hydrogen cyanide, as was first shown by Pozzani "et al." in 1959. The first step in this pathway is the oxidation of acetonitrile to
Nail polish and while formaldehyde has been eliminated from some nail polish brands, others still use it. The U.S. city of San Francisco enacted a city ordinance, publicly identifying establishments that use nail polishes free of the "toxic trio" of dibutyl phthalate, toluene, and formaldehyde. Nail polish is considered a hazardous waste by some regulatory bodies such as the Los Angeles Department of Public Works. Many countries have strict restrictions on sending nail polish by mail. The "toxic trio" are currently being phased out, but there are still components of nail polish that could cause environmental concern. Leaking out of the bottle