Blood type if they can bind to the corresponding antibodies to generate an immune response. Transfusions are further complicated because platelets and white blood cells (WBCs) have their own systems of surface antigens, and sensitization to platelet or WBC antigens can occur as a result of transfusion. For transfusions of plasma, this situation is reversed. Type O plasma, containing both anti-A and anti-B antibodies, can only be given to O recipients. The antibodies will attack the antigens on any other blood type. Conversely, AB plasma can be given to patients of any ABO blood group, because it does not contain any anti-A
Jehovah's Witnesses and blood transfusions and other blood-borne infections, or immune system reactions. Many physicians have expressed a willingness to respect patients' preferences and provide bloodless treatment and about 200 hospitals offer bloodless medicine and surgery programs for patients who wish to avoid or limit blood transfusions. Bloodless surgery has been successfully performed in significant procedures including open-heart surgery and total hip replacements. A 2012 study in "JAMA Internal Medicine" concluded that "Witnesses do not appear to be at increased risk for surgical complications or long-term mortality when comparisons are properly made by transfusion status. Thus, current extreme blood management strategies do not appear to