Kyoto Protocol European Union-15, made up of 15 states at the time of the Kyoto negotiations) commit themselves to binding targets for GHG emissions. The targets apply to the four greenhouse gases carbon dioxide (), methane (), nitrous oxide (), sulphur hexafluoride (), and two groups of gases, hydrofluorocarbons (HFCs) and perfluorocarbons (PFCs). The six GHG are translated into CO equivalents in determining reductions in emissions. These reduction targets are in addition to the industrial gases, chlorofluorocarbons, or CFCs, which are dealt with under the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Under the Protocol, only the Annex I
Nitrous oxide and inhibit pain signalling. Exactly how causes the release of endogenous opioid peptides remains uncertain. Nitrous oxide is a colourless, non-toxic gas with a faint, sweet odour. Nitrous oxide supports combustion by releasing the dipolar bonded oxygen radical, thus it can relight a glowing splint. The above reaction is the route adopted by the commercial chemical industry to produce azide salts, which are used as detonators. The gas was first synthesised in 1772 by English natural philosopher and chemist Joseph Priestley, who called it "phlogisticated nitrous air" (see phlogiston) or "inflammable nitrous air". Priestley published his discovery in the book