Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Wireless Application Protocol protocol design was appropriate. Some have suggested that the bandwidth-sparing simple interface of Gopher would be a better match for mobile phones and Personal digital assistants (PDAs). The initial design of WAP specifically aimed at protocol independence across a range of different protocols (SMS, IP over PPP over a circuit switched bearer, IP over GPRS, etc.). This has led to a protocol considerably more complex than an approach directly over IP might have caused. Most controversial, especially for many from the IP side, was the design of WAP over IP. WAP's transmission layer protocol, WTP, uses its own retransmission mechanisms