Hippocampus Thomas Henry Huxley and Richard Owen, satirised as the Great Hippocampus Question. The term hippocampus minor fell from use in anatomy textbooks, and was officially removed in the Nomina Anatomica of 1895. Today, the structure is just called the hippocampus, with the term "Cornu Ammonis" surviving in the names of the hippocampal subfields CA1-CA4. The term "limbic system" was introduced in 1952 by Paul MacLean to describe the set of structures that line the edge of the cortex (Latin "limbus" meaning "border"): These include the hippocampus, cingulate cortex, olfactory cortex, and amygdala. Paul MacLean later suggested that the limbic structures
Early long-term potentiation which reflects their deficit in late phase LTP. Training of simple reflexes in Aplysia has shown a strengthening between sensory and motor neurons responsible for those reflexes; on a cellular level, for short-term memory (and thus, early LTP) potentiation leads to an increase in presynaptic neurotransmitter by means of modifications of proteins through cAMP-dependent PKA and PKC. The long-term process requires new protein synthesis and CAMP-mediated gene expression, and results in the growth of new synaptic connections. These findings have led to the question whether there is a similar process in mammals. Input to the hippocampus comes from the neurons