Post-nasal drip Post-nasal drip Post-nasal drip (PND, also termed upper airway cough syndrome, UACS, or post nasal drip syndrome, PNDS) occurs when excessive mucus is produced by the nasal mucosa. The excess mucus accumulates in the back of the nose and eventually the throat once it drips down the back of the throat. It is caused by rhinitis, sinusitis, gastroesophageal reflux disease (GERD), or by a disorder of swallowing (such as an esophageal motility disorder). But also further sources such as an allergy, cold or flu and as a result of medications. However, researchers argue that the flow of mucus down the
Nasal administration Nasal administration Nasal administration is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. Nasal sprays are locally acting drugs such as decongestants for cold and allergy treatment, whose systemic effects are usually minimal. Examples of systemically active drugs available as nasal sprays are migraine drugs, nicotine replacement, and hormone treatments. The nasal cavity is covered by a thin mucosa which is well vascularised. Therefore, a drug molecule