Nitrous oxide inside the cells, by a process catalyzed by the enzyme nitrous oxide reductase. Nitrous oxide has significant global warming potential as a greenhouse gas. On a per-molecule basis, considered over a 100-year-period, nitrous oxide has 298 times the atmospheric heat-trapping ability of carbon dioxide (), however, because of its low concentration (less than 1/1000 of that of ), its contribution to the greenhouse effect is less than one-third that of carbon dioxide, and also less than water vapour and methane. On the other hand, since 38% or more of the entering the atmosphere is the result of human activity, and
Nitrous oxide it in all his "Colton Dental Association" clinics, that he had just established in New Haven and New York City. Over the following three years, Colton and his associates successfully administered nitrous oxide to more than 25,000 patients. Today, nitrous oxide is used in dentistry as an anxiolytic, as an adjunct to local anaesthetic. Nitrous oxide was not found to be a strong enough anaesthetic for use in major surgery in hospital settings, however. Instead, diethyl ether, being a stronger and more potent anaesthetic, was demonstrated and accepted for use in October 1846, along with chloroform in 1847. When Joseph