Acetonitrile formulations for nail polish remover, despite its toxicity. At least two cases have been reported of accidental poisoning of young children by acetonitrile-based nail polish remover, one of which was fatal. Acetone and ethyl acetate are often preferred as safer for domestic use, and acetonitrile has been banned in cosmetic products in the European Economic Area since March 2000. In common with other nitriles, acetonitrile can be metabolised in microsomes, especially in the liver, to produce hydrogen cyanide, as was first shown by Pozzani "et al." in 1959. The first step in this pathway is the oxidation of acetonitrile to
PEAR of PEAR and PECL extensions. On PHP installations running on Linux, the PEAR package manager is ready for usage by default, but on Windows the PEAR package manager is only available after running a batch file called codice_2. With Pyrus an attempt was undertaken to redesign and improve PEAR from the ground up for PHP 5.3 or newer. Pyrus can be used to install packages from PEAR channels. The last release is from March 2011 and its development might have been discontinued due to the popularity of Composer. With Composer there is an alternative available for managing packages for a