Nail polish can be harsh on skin and nails. Acetone can also remove artificial nails made of acrylic or cured gel. A less harsh nail polish remover is ethyl acetate, which often also contains isopropyl alcohol. Ethyl acetate is usually the original solvent for nail polish itself. Acetonitrile has been used as a nail polish remover, but it is more toxic and potentially more carcinogenic than the aforementioned options. It has been banned in the European Economic Area for use in cosmetics since 17 March 2000. The health risks associated with nail polish are disputed. According to the U.S. Department of Health
Nail polish and carbon disulfide may have adverse effects on reproductive health. These effects may including birth defects, low birth weight, miscarriage, and preterm birth. Nail polish formulations may include ingredients that are toxic or affect other health problems. One controversial family of ingredient are phthalates, which are implicated as endocrine disruptors and linked to problems in the endocrine system and increased risk of diabetes. Manufacturers have been pressured by consumer groups to reduce or to eliminate potentially-toxic ingredients, and in September 2006, several companies agreed to phase out dibutyl phthalates. There are no universal consumer safety standards for nail polish, however,