Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Old Crow Medicine Show of the New Lost City Ramblers, the Jim Kweskin Jug Band, Canned Heat, The Lovin' Spoonful, Dylan and The Band in the basement, and the Grateful Dead. When Secor, Fuqua, and company first got together "old-timey pickers their age were few and far between. Modern rock was still a force to be reckoned with. Now hard-driving string bands are where it's at." Fuqua recalls: To Americana Music Association (AMA) President Jed Hilly, the historic path of Americana music passes through the group: "The baton is passed from Emmylou Harris to Gillian Welch and David Rawlings to Old Crow Medicine Show