ABO blood group system gives type O. As both "I" and "I" are dominant over "i", only "ii" people have type O blood. Individuals with "II" or "Ii" have type A blood, and individuals with "II" or "Ii" have type B. "II" people have both phenotypes, because A and B express a special dominance relationship: codominance, which means that type A and B parents can have an AB child. A couple with type A and type B can also have a type O child if they are both heterozygous ("Ii","Ii"). The "cis-AB" phenotype has a single enzyme that creates both A and B antigens.
ABO blood group system B, and AB blood into type O. This is done by using glycosidase enzymes from specific bacteria to strip the blood group antigens from red blood cells. The removal of A and B antigens still does not address the problem of the Rh blood group antigen on the blood cells of Rh positive individuals, and so blood from Rh negative donors must be used. Patient trials will be conducted before the method can be relied on in live situations. Another approach to the blood antigen problem is the manufacture of artificial blood, which could act as a substitute in emergencies.