Nitrous oxide inside the cells, by a process catalyzed by the enzyme nitrous oxide reductase. Nitrous oxide has significant global warming potential as a greenhouse gas. On a per-molecule basis, considered over a 100-year-period, nitrous oxide has 298 times the atmospheric heat-trapping ability of carbon dioxide (), however, because of its low concentration (less than 1/1000 of that of ), its contribution to the greenhouse effect is less than one-third that of carbon dioxide, and also less than water vapour and methane. On the other hand, since 38% or more of the entering the atmosphere is the result of human activity, and
Nitrous oxide because has a very short duration under normal circumstances, it is less likely to be neurotoxic than other NMDA antagonists. Indeed, in rodents, short-term exposure results in only mild injury that is rapidly reversible, and neuronal death occurs only after constant and sustained exposure. Nitrous oxide also may cause neurotoxicity after extended exposure because of hypoxia. This is especially true of non-medical formulations such as whipped-cream chargers (also known as "whippets" or "nangs"), which never contain oxygen, since oxygen makes cream rancid. Additionally, nitrous oxide depletes vitamin B levels. This can cause serious neurotoxicity if the user has preexisting vitamin