Hippocampus Thomas Henry Huxley and Richard Owen, satirised as the Great Hippocampus Question. The term hippocampus minor fell from use in anatomy textbooks, and was officially removed in the Nomina Anatomica of 1895. Today, the structure is just called the hippocampus, with the term "Cornu Ammonis" surviving in the names of the hippocampal subfields CA1-CA4. The term "limbic system" was introduced in 1952 by Paul MacLean to describe the set of structures that line the edge of the cortex (Latin "limbus" meaning "border"): These include the hippocampus, cingulate cortex, olfactory cortex, and amygdala. Paul MacLean later suggested that the limbic structures
Long-term memory brain. This gets worse over time and eventually leads to cognitive decline, after the loss of memory. Pioglitazone may improve cognitive impairments, including memory loss and may help protect long-term and visiospatial memory from neurodegenerative disease. Parkinson's disease patients have problems with cognitive performance; these issues resemble what is seen in frontal lobe patients and can often lead to dementia. It is thought that Parkinson's disease is caused by degradation of the dopaminergic mesocorticolimbic projection originating from the ventral tegmental area. It has also been indicated that the hippocampus plays an important role in episodic and spatial (parts of LTM)