What Becomes of the Brokenhearted singers The Originals and The Andantes. "What Becomes of the Brokenhearted" peaked at number seven on the "Billboard" Hot 100, and at number six on the Billboard R&B Singles chart, as well as No. 8 on the UK Chart. Eight years later, the song was reissued (with a B-Side of Ruffin's minor US hit "Don't You Miss Me a Little Bit Baby"), and surpassed its original chart position, reaching No. 4, and thus making it his highest-placed chart single in the UK. The song originally featured a spoken introduction by Ruffin, similar in style to many of Lou Rawls' performances
Effective number of codons Effective number of codons Effective number of codons (abbreviated as ENC or "Nc") is a measure to study the state of codon usage biases in genes and genomes. The way that ENC is computed has obvious similarities to the computation of effective population size in population genetics. Although it is easy to compute ENC values, it has been shown that this measure is one of the best measures to show codon usage bias. Since the original suggestion of the ENC, several investigators have tried to improve the method, but it seems that there is much room to improve this measure.