ABO blood group system and likely predates human migration from Africa. The O01 allele is considered to predate the O02 allele. Some evolutionary biologists theorize that there are four main lineages of the ABO gene and that mutations creating type O have occurred at least three times in humans. From oldest to youngest, these lineages comprise the following alleles: "A101/A201/O09", "B101", "O02" and "O01". The continued presence of the O alleles is hypothesized to be the result of balancing selection. Both theories contradict the previously held theory that type O blood evolved first. It is possible that food and environmental antigens (bacterial, viral, or
Human blood group systems three types of cells: The most common type of grouping is the ABO blood group system. The varieties of glycoprotein and glycolipid coating on red blood cells divides blood into four groups: Another antigen, the Rh factor, plays an important part in the grouping of blood. If this is present, the particular blood type is called Rh-positive. If it is absent, it is called Rh-negative. In addition to the ABO and Rh blood group systems, there are more than two hundred minor blood groups that can complicate blood transfusions. These are known as rare blood types. Whereas common blood types