Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Old Crow Medicine Show the folk tradition—"like when he penned fresh, war tax-themed lyrics to a tune that had already passed through other wholesale re-writes during its descent from old-time Scots-Irish balladry." Dave Rawlings states: "I've always thought that a really important thing that the Old Crow Medicine Show brought to the table was new songs—some reinterpreted old ones, some really nicely written and brand new—with the old flavor, but also with that vitality." In August 2014, Downtown Music Publishing signed a worldwide publishing agreement with Old Crow Medicine Show. This agreement covers all five of the band's studio albums, including 'Remedy'. An early