Laudanum Concerning the History and Cure of Acute Diseases", in which he promoted his brand of opium tincture, and advocated its use for a range of medical conditions. By the 18th century, the medicinal properties of opium and laudanum were well known, and the term "laudanum" came to refer to any combination of opium and alcohol. Several physicians, including John Jones, John Brown, and George Young, the latter of whom published a comprehensive medical text entitled "Treatise on Opium", extolled the virtues of laudanum and recommended the drug for practically every ailment. "Opium, and after 1820, morphine, was mixed with everything
Desensitization (medicine) Desensitization (medicine) In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus. In pharmacology, "drug desensitization" is equivalent to drug tolerance, though the latter term refers to the more general concept of subjects' reactions (positive or negative) to a drug reducing following its repeated use. For example, if a person with diabetes mellitus has a bad allergic reaction to taking a full dose of beef insulin, the person is given a very small amount of the insulin at first, so small that the person has no adverse reaction or very limited