ABO blood group system gives type O. As both "I" and "I" are dominant over "i", only "ii" people have type O blood. Individuals with "II" or "Ii" have type A blood, and individuals with "II" or "Ii" have type B. "II" people have both phenotypes, because A and B express a special dominance relationship: codominance, which means that type A and B parents can have an AB child. A couple with type A and type B can also have a type O child if they are both heterozygous ("Ii","Ii"). The "cis-AB" phenotype has a single enzyme that creates both A and B antigens.
ABO blood group system A-type blood, with A2 making up almost all of the rest. These two subgroups are not always interchangeable as far as transfusion is concerned, as some A2 individuals produce antibodies against the A1 antigen. Complications can sometimes arise in rare cases when typing the blood. With the development of DNA sequencing, it has been possible to identify a much larger number of alleles at the ABO locus, each of which can be categorized as A, B, or O in terms of the reaction to transfusion, but which can be distinguished by variations in the DNA sequence. There are six common