ABO blood group system alleles in white individuals of the ABO gene that produce one's blood type: The same study also identified 18 rare alleles, which generally have a weaker glycosylation activity. People with weak alleles of A can sometimes express anti-A antibodies, though these are usually not clinically significant as they do not stably interact with the antigen at body temperature. Cis AB is another rare variant, in which A and B genes are transmitted together from a single parent. The distribution of the blood groups A, B, O and AB varies across the world according to the population. There are also variations
Jehovah's Witnesses and blood transfusions eating blood to prohibit the medical transfusion of human blood. Osamu Muramoto has argued that the refusal by Jehovah's Witnesses of "life-saving" blood treatment creates serious bio-medical ethical issues. He has criticized the "controlling intervention" of the Watch Tower Society by means of what he claims is information control and its policy of penalising members who accept blood transfusions or advocate freedom to choose blood-based treatment. He says the threat of being classified as a disassociated Witness and subsequently shunned by friends and relatives who are members coerces Jehovah's Witnesses to accept and obey the prohibition on blood transfusions. In