Laudanum his "archanum" or "laudanum", may or may not have contained opium. Paracelsus' laudanum was strikingly different from the standard laudanum of the 17th century and beyond, containing crushed pearls, musk, amber, and other substances. One researcher has documented that "Laudanum, as listed in the "London Pharmacopoeia" (1618), was a pill made from opium, saffron, castor, ambergris, musk and nutmeg". Laudanum remained largely unknown until the 1660s when English physician Thomas Sydenham (1624–1689) compounded a proprietary opium tincture that he also named laudanum, although it differed substantially from the laudanum of Paracelsus. In 1676 Sydenham published a seminal work, "Medical Observations
Mosses from an Old Manse Mosses from an Old Manse Mosses from an Old Manse is a short story collection by Nathaniel Hawthorne, first published in 1846. The collection includes several previously-published short stories, and was named in honor of The Old Manse where Hawthorne and his wife lived for the first three years of their marriage. The first edition was published in 1846. Hawthorne seems to have been paid $75 for the publication. Many of the tales collected in "Mosses from an Old Manse" are allegories and, typical of Hawthorne, focus on the negative side of human nature. Hawthorne's friend Herman Melville noted this