Global cooling wrote their 1971 paper, climatologists had not yet recognized the significance of greenhouse gases other than water vapor and carbon dioxide, such as methane, nitrous oxide, and chlorofluorocarbons. Early in that decade, carbon dioxide was the only widely studied human-influenced greenhouse gas. The attention drawn to atmospheric gases in the 1970s stimulated many discoveries in subsequent decades. As the temperature pattern changed, global cooling was of waning interest by 1979. A common argument used to dispute the significance of human caused climate change, which TIME Magazine calls the Ice Age Fallacy, is to allege that scientists showed concerns about global
Sulfur dioxide are mediated via ATP-dependent calcium channels and L-type ("dihydropyridine") calcium channels. Endogenous sulfur dioxide is also a potent antiinflammatory, antioxidant and cytoprotective agent. It lowers blood pressure and slows hypertensive remodeling of blood vessels, especially thickening of their intima. It also regulates lipid metabolism. Endogenous sulfur dioxide also diminishes myocardial damage, caused by isoproterenol adrenergic hyperstimulation, and strengthens the myocardial antioxidant defense reserve. Being easily condensed and possessing a high heat of evaporation, sulfur dioxide is a candidate material for refrigerants. Prior to the development of chlorofluorocarbons, sulfur dioxide was used as a refrigerant in home refrigerators. Sulfur dioxide is