Hippocampus Thomas Henry Huxley and Richard Owen, satirised as the Great Hippocampus Question. The term hippocampus minor fell from use in anatomy textbooks, and was officially removed in the Nomina Anatomica of 1895. Today, the structure is just called the hippocampus, with the term "Cornu Ammonis" surviving in the names of the hippocampal subfields CA1-CA4. The term "limbic system" was introduced in 1952 by Paul MacLean to describe the set of structures that line the edge of the cortex (Latin "limbus" meaning "border"): These include the hippocampus, cingulate cortex, olfactory cortex, and amygdala. Paul MacLean later suggested that the limbic structures
Long-term memory is important for the persistence of long-term memories. The long-term stabilization of synaptic changes is also determined by a parallel increase of pre- and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density. On the molecular level, an increase of the postsynaptic scaffolding proteins PSD-95 and Homer1c has been shown to correlate with the stabilization of synaptic enlargement. The cAMP response element-binding protein (CREB) is a transcription factor which is believed to be important in consolidating short-term to long-term memories, and which is believed to be downregulated in Alzheimer's disease. A couple of studies have had results that