Trifluoroacetic acid Trifluoroacetic acid Trifluoroacetic acid (TFA) is an organofluorine compound with the chemical formula CFCOH. It is a structural analogue of acetic acid with all three of the acetyl group’s hydrogen atoms replaced by fluorine atoms and is a colorless liquid with a vinegar like odor. TFA is a stronger acid than acetic acid, having an acid ionisation constant that is approximately 34,000 times higher, as the highly electronegative fluorine atoms and consequent electron-withdrawing nature of the trifluoromethyl group weakens the oxygen-hydrogen bond (allowing for greater acidity) and stabilises the anionic conjugate base. TFA is widely used in organic chemistry for
Nonanoic acid Nonanoic acid Nonanoic acid, also called pelargonic acid, is an organic compound with structural formula CH(CH)COH. It is a nine-carbon fatty acid. Nonanoic acid is a colorless oily liquid with an unpleasant, rancid odor. It is nearly insoluble in water, but very soluble in organic solvents. The esters and salts of nonanoic acid are called nonanoates. Its refractive index is 1.4322. Its critical point is at 712 K (439 °C) and 2.35 MPa. Nonanoic acid occurs naturally as esters in the oil of pelargonium. Together with azelaic acid, it is produced industrially by ozonolysis of oleic acid. Synthetic esters of