How Many Licks? remaining on the chart for 20 weeks. "How Many Licks?" also charted in several other countries. It peaked at number six on the Dutch Top 40 chart, and remained on the chart for 13 weeks. The single reached number seven on the Ultratop chart in the Flanders region of Belgium, also remaining on that chart for 13 weeks. It further peaked at number 58 on the German Singles Chart, remaining for eight editions. The song's music video, directed by Francis Lawrence, was shot in the Sylmar, Los Angeles neighborhood of Los Angeles on October 3 and 4, 2000, and premiered
Cruciferous vegetables to isothiocyanates (ITCs) by the action of myrosinase. ITCs, possibly a bioactive component in cruciferous vegetables, are being investigated for their chemopreventive and chemotherapeutic effects. As one example in laboratory research, ITCs such as phenethyl isothiocyanate reduced levels of the oncoprotein MCL1. Other in vitro research indicates ITCs may affect levels of the BCR-ABL fusion protein, the oncoprotein affecting mechanisms of leukemia. Chemicals contained in cruciferous vegetables induce the expression of the liver enzyme CYP1A2. Furthermore, some drugs such as haloperidol and theophylline are metabolized by CYP1A2. Consequently, consumption of cruciferous vegetables may decrease bioavailability and half-life of these drugs.