Laudanum his "archanum" or "laudanum", may or may not have contained opium. Paracelsus' laudanum was strikingly different from the standard laudanum of the 17th century and beyond, containing crushed pearls, musk, amber, and other substances. One researcher has documented that "Laudanum, as listed in the "London Pharmacopoeia" (1618), was a pill made from opium, saffron, castor, ambergris, musk and nutmeg". Laudanum remained largely unknown until the 1660s when English physician Thomas Sydenham (1624–1689) compounded a proprietary opium tincture that he also named laudanum, although it differed substantially from the laudanum of Paracelsus. In 1676 Sydenham published a seminal work, "Medical Observations
The Owl Drug Company Francisco, at 1128 Market Street. In 1903, with their contract with the Whitall Tatum Glass Company, they began making triangular, cobalt-blue bottles of various sizes to store poisons in, which was widely emulated. According to the book "Old Owl Drug Bottles & Others" (1968), Owl Drug created a variety of bottles for prescription medicine and pills, and also soda bottles, with an owl sitting atop a mortar and pestle molded into the glass. The bottles were produced in various sizes from up to a (rarer) , over in height. The bottles were also produced in other colors such as green,