Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Here Comes an Old Soldier from Botany Bay Here Comes an Old Soldier from Botany Bay Here Comes an Old Soldier from Botany Bay, commonly known as Here Comes an Old Soldier or just Old Soldier, is a nursery rhyme and children's game found in Australia, the United States, and the British Isles. The game and rhyme date to at least the late nineteenth century. <poem>Here comes an old soldier from Botany Bay, Have you got anything to give him to-day.</poem> The idea being for each person in turn to name and item and then others add theirs until a long list has to be remembered. <br>For example:<br>