Human hair color account for all possible shades of brown, blond, or red (for example, platinum blond versus dark blond/light brown), nor does it explain why hair color sometimes darkens as a person ages. Several gene pairs control the light versus dark hair color in a cumulative effect. A person's genotype for a multifactorial trait can interact with the environment to produce varying phenotypes (see quantitative trait locus). Natural hair color can be brown, blond, black, red, or white; all natural hair colors including grey, white and lightest blond, are shades of brown. The Fischer–Saller scale, named after Eugen Fischer and , is
Eye color for a plausible argument stating that some eyes can or do change, based on chemical reactions and hormonal changes within the body. Studies on Caucasian twins, both fraternal and identical, have shown that eye color over time can be subject to change, and major demelanization of the iris may also be genetically determined. Most eye-color changes have been observed or reported in the Caucasian population with hazel and amber eyes. Carleton Coon created a chart by the original Martin scale. The numbering is reversed on the scale below in the (later) Martin–Schultz scale, which is (still) used in physical anthropology.