2010 Quick-Step season entered the Tour of Qatar with two-time defending champion Boonen leading their squad. Boonen won two stages in the race, but a two-man breakaway in the race's second stage proved critical, as it afforded Wouter Mol and Geert Steurs the top two steps on the podium by more than a minute over the rest of the field. Boonen finished third overall. Quick Step came to the Giro with a squad headed by Cataldo. Seeldraeyers, who had won the youth classification in the 2009 Giro d'Italia, was kept off the squad in favor of the Tour de France. Weylandt was included
Adam Yates (cyclist) chin requiring stitches, but after the stage results were revised to give him the 7 second advantage he had over the peloton with 3 km to go, Yates rose to second overall and took the White Jersey as leader of the Young rider classification from Julian Alaphilippe (Etixx–Quick-Step). On Stage 9, which was the first mountain top finish of the race at Andorre Arcalis, Yates finished tenth, leading home a select group of GC contenders including Chris Froome (Team Sky), Nairo Quintana (Movistar Team), Richie Porte (BMC Racing Team) and Daniel Martin (Etixx-QuickStep). This meant Yates sat second overall going