Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
The Owl Drug Company Francisco, at 1128 Market Street. In 1903, with their contract with the Whitall Tatum Glass Company, they began making triangular, cobalt-blue bottles of various sizes to store poisons in, which was widely emulated. According to the book "Old Owl Drug Bottles & Others" (1968), Owl Drug created a variety of bottles for prescription medicine and pills, and also soda bottles, with an owl sitting atop a mortar and pestle molded into the glass. The bottles were produced in various sizes from up to a (rarer) , over in height. The bottles were also produced in other colors such as green,