Cloud Nine (Kottonmouth Kings album) by band member Pakelika. It is meant to show that it is their ninth official album and also referred to the so-called "greatness of being high with the heavens". (From informal English: "to be on cloud nine" - to be extremely happy) As of the week of September 15, 2007 the album debuted at number 44 on the U.S. "Billboard" 200 chart, selling about 14,000 copies in its first week, #10 on the "Billboard"s Top Rap Albums, and #3 on the Top Independent Albums chart. The albums also made it to #45 on the Billboard Comprehensive Albums, #44 on the
Allotopic expression Allotopic expression Allotopic expression (AE) refers to expression of genes in the cell nucleus that normally are expressed only from the mitochondrial genome. Biomedically engineered AE has been suggested as a possible future tool in gene therapy of certain mitochondria-related diseases, however this view is controversial. While this type of expression has been successfully carried out in yeast, the results in mammals have been conflicting. Gensight Biologics are currently pursuing a clinical program of expressing the ND4 gene in the nucleus to prevent retinal disease. The SENS Research Foundation recently reported success in expressing the ATP6 gene allotopically in vitro.