Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Protocol (politics) Protocol (politics) Protocol can mean any logbook or other artifact (forged or authentic) of a political meeting between persons from different nations. The most notorious example of a forged logbook is "The Protocols of the Elders of Zion". In international law, a treaty that supplements or adds to a pre-existing treaty is often given a name that includes "Protocol" in its title. For example, the Kyoto Protocol was supplemental to the United Nations Framework Convention on Climate Change; Protocol I, Protocol II, and Protocol III supplement the 1949 Geneva Conventions; and the Convention on the Elimination of All Forms of