Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Psychoactive Substances Act 2013 will be difficult or impossible. So far, no manufacturing licenses have been applied for. The Act was brought in as a reaction to widespread concerns over the 2005 deregulation, or decriminalisation, of selling psychoactive substances in New Zealand with the introduction of section 62 in the Misuse of Drugs Amendment Act 2005 and the Misuse of Drugs (Restricted Substances) Regulations 2008. These laws made psychoactive substances such as party pills and legal highs available in New Zealand in a relatively new experimental market aimed at decriminalising the production and sale of recreational drugs. Psychoactive Substances Act 2013 The Psychoactive Substances