Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Protocol amending the Single Convention on Narcotic Drugs Protocol amending the Single Convention on Narcotic Drugs The 1972 Protocol amending the Single Convention on Narcotic Drugs was a protocol that made several changes to the Single Convention on Narcotic Drugs. It highlighted the need for treatment and rehabilitation of drug addicts, instructing parties to take "all practicable measures for the prevention of abuse of psychotropic substances and for the early identification, treatment, education, after-care, rehabilitation, and social reintegration of the persons involved". It also expanded the International Narcotics Control Board from 11 members to 13 members. In addition, the Protocol added Article 21 bis, "Limitation of Production of