Blood type transfusion can be considered safe as long as the serum of the recipient does not contain antibodies for the blood cell antigens of the donor. The "ABO system" is the most important blood-group system in human-blood transfusion. The associated anti-A and anti-B antibodies are usually "immunoglobulin M", abbreviated IgM, antibodies. ABO IgM antibodies are produced in the first years of life by sensitization to environmental substances such as food, bacteria, and viruses. The original terminology used by Karl Landsteiner in 1901 for the classification was A/B/C; in later publications "C" became "O". Type O is often called "0" ("zero", or
Blood type personality theory methodology of his conclusions was unclear. Because of this, he was heavily criticized by the Japanese psychological community, although his books remain popular. His son, Toshitaka Nomi, continued to promote the theory with a series of books and by running the Institute of Blood Type Humanics. He later established the Human Science ABO Center for further research and publication in 2004. Some researchers believe blood types are associated with personality traits. Many medical surveys have been conducted, such as those for hormone secretion traits (DBH, COMT, MAO etc.), or the blood-type antigens in neurons, or the antigens expressed on surfaces