Hippocampus Thomas Henry Huxley and Richard Owen, satirised as the Great Hippocampus Question. The term hippocampus minor fell from use in anatomy textbooks, and was officially removed in the Nomina Anatomica of 1895. Today, the structure is just called the hippocampus, with the term "Cornu Ammonis" surviving in the names of the hippocampal subfields CA1-CA4. The term "limbic system" was introduced in 1952 by Paul MacLean to describe the set of structures that line the edge of the cortex (Latin "limbus" meaning "border"): These include the hippocampus, cingulate cortex, olfactory cortex, and amygdala. Paul MacLean later suggested that the limbic structures
Long-term potentiation is an atypical isoform of PKC that lacks a regulatory subunit and thus remains constitutively active. Unlike other kinases that mediate LTP, PKMζ is active not just in the first 30 minutes following LTP induction; rather, PKMζ becomes a requirement for LTP maintenance only during the late phase of LTP. PKMζ thus appears important for the persistence of memory and would be expected to be important in the maintenance of long-term memory. Indeed, administration of a PKMζ inhibitor into the hippocampus of the rat results in retrograde amnesia with intact short-term memory; PKMζ does not play a role in the