Rh blood group system the clinical consequences of non-recognized "Rh factor", hemolytic transfusion reaction, and hemolytic disease of the newborn in its most severe form. It was recognized that the serum of the reported woman agglutinated with red blood cells of about 80% of the people although the then known blood groups, in particular ABO were matched. No name was given to this agglutinin when described. In 1940, Karl Landsteiner and Alexander S. Wiener made the connection to their earlier discovery, reporting a serum that also reacted with about 85% of different human red blood cells. In 1941, Group O: a patient of Dr.
Rh blood group system factor is not identical to the rhesus monkey factor; but by then, "Rhesus Group" and like terms were already in widespread, worldwide use. Thus, notwithstanding it is a misnomer, the term survives (e.g. "rhesus blood group system", and the obsolete terms "rhesus factor", " rhesus positive", and "rhesus negative" - all three which actually refer specifically and "only" to the Rh D factor; and, thus, are misleading when unmodified). Contemporary practice is to use "Rh" as a term of art instead of "Rhesus"; viz. "Rh Group," "Rh factors," "Rh D," etc. The first rhesus blood type was discovered in 1937