Patent medicine the patent medicines, some of their makers began replacing the opium tincture laudanum with acetanilide, a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been introduced into medical practice under the name "Antifebrin" by A. Cahn and P. Hepp in 1886. But this ingredient change probably killed more of the nostrum's users than the original narcotics did, since acetanilide not only caused an alarming cyanosis due to methemoglobinemia but was later discovered to cause liver and kidney damage. The occasional reports of acetanilide-induced cyanosis prompted the search for supposedly less toxic aniline derivatives, such
Drug Houses of Australia Drug Houses of Australia Drug Houses of Australia (DHA) was originally established in 1936 as an amalgamation of seven Australian pharmaceutical companies, notably A. M. Bickford & Sons. In 1970, DHA was taken over by the British bank Slater Walker. Drug Houses of Australia is now a leading generic pharmaceutics and Chinese proprietary medicine (CPM) manufacturer based in Jurong, Singapore. It was sold to Strides Arcolab through a share purchase agreement with Haw Par Healthcare Limited, Singapore in September 2006 for approximately SGD$19.7 million. It is currently a part of Strides Arcolab which is listed on both the Indian stock