Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
1987 Montreal Alouettes season 1987 Montreal Alouettes season The 1987 Montreal Alouettes played two preseason games before folding on June 24, 1987, just one day before their scheduled Thursday game against the Toronto Argonauts. The many years of bad ownership and dwindling fan support finally led to the CFL pulling the plug on the franchise and folding them. Since Sam Berger sold the team in 1981, it had shaky ownership and years of poor football performances, only playing .500 ball once (in 1985) and making the playoffs twice (winning only one game in 1985), leading to it playing in a to near-empty Olympic Stadium