ABO blood group system roles in cell membrane integrity, cell adhesion, membrane transportation of molecules, and acting as receptors for extracellular ligands, and enzymes. ABO antigens are found having similar roles on epithelial cells as well as red blood cells. The ABO antigen is also expressed on the von Willebrand factor (vWF) glycoprotein, which participates in hemostasis (control of bleeding). In fact, having type O blood predisposes to bleeding, as 30% of the total genetic variation observed in plasma vWF is explained by the effect of the ABO blood group, and individuals with group O blood normally have significantly lower plasma levels of vWF
Rh blood group system factor is not identical to the rhesus monkey factor; but by then, "Rhesus Group" and like terms were already in widespread, worldwide use. Thus, notwithstanding it is a misnomer, the term survives (e.g. "rhesus blood group system", and the obsolete terms "rhesus factor", " rhesus positive", and "rhesus negative" - all three which actually refer specifically and "only" to the Rh D factor; and, thus, are misleading when unmodified). Contemporary practice is to use "Rh" as a term of art instead of "Rhesus"; viz. "Rh Group," "Rh factors," "Rh D," etc. The first rhesus blood type was discovered in 1937