Metered-dose inhaler stringent set of criteria, they must: In the early days of MDIs the most commonly used propellants were the chlorofluorocarbons CFC-11, CFC-12 and CFC-114. In 2008 the Food and Drug Administration announced that inhalers using chlorofluorocarbons as a propellant, such as Primatene Mist, could no longer be manufactured or sold as of 2012. This followed from the U.S. decision to agree to the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. Phospholipids are important natural surfactant lipids used in enhancing penetration and bioavailability. Phospholipids act by reducing the high surface tension forces at the air-water interface within the
Beyond Protocol the community project "After Protocol" as open source continuation. In a 2008 GameSpy preview, Beyond Protocol was hailed for its "Customizable units; incredibly deep strategy; economic wheeling and dealing; player democracy", while noting concerns about balancing. Beyond Protocol Beyond Protocol was a subscription based Sci-Fi Massively multiplayer online real-time strategy game (MMORTS) Computer Game developed by the American independent game developer Dark Sky Entertainment and released in November 2008. The 3D game modelled a persistent and player-driven fictional galaxy. Beyond Protocol was an entirely Player versus player (PvP) game, no Non-player characters (NPCs) exist within the game, all activities (trade,