Cyanoacrylate cyanoacrylate to some natural materials such as cotton (jeans, cotton swabs, cotton balls, and certain yarns or fabrics), or leather or wool results in a powerful, rapid, exothermic reaction. This reaction also occurs with fiberglass and carbon fiber. The heat released may cause serious burns or release irritating white smoke. Material Safety Data Sheets for cyanoacrylate instruct users not to wear cotton (jeans) or wool clothing, especially cotton gloves, when applying or handling cyanoacrylates. Acetone, commonly found in nail polish remover, is a widely available solvent capable of softening cured cyanoacrylate. Other solvents include nitromethane, dimethyl sulfoxide, and methylene chloride.
Nail polish and carbon disulfide may have adverse effects on reproductive health. These effects may including birth defects, low birth weight, miscarriage, and preterm birth. Nail polish formulations may include ingredients that are toxic or affect other health problems. One controversial family of ingredient are phthalates, which are implicated as endocrine disruptors and linked to problems in the endocrine system and increased risk of diabetes. Manufacturers have been pressured by consumer groups to reduce or to eliminate potentially-toxic ingredients, and in September 2006, several companies agreed to phase out dibutyl phthalates. There are no universal consumer safety standards for nail polish, however,