Acid–base reaction liquid ammonia are similar to the reactions in water: Nitric acid can be a base in liquid sulfuric acid: The unique strength of this definition shows in describing the reactions in aprotic solvents; for example, in liquid : Because the solvent system definition depends on the solute as well as on the solvent itself, a particular solute can be either an acid or a base depending on the choice of the solvent: is a strong acid in water, a weak acid in acetic acid, and a weak base in fluorosulfonic acid; this characteristic of the theory has been seen as
Acid–base imbalance Any combination is possible, as metabolic acidosis and alkalosis can co exist together. The traditional approach to the study of acid–base physiology has been the empirical approach. The main variants are the base excess approach and the bicarbonate approach. The quantitative approach introduced by Peter A Stewart in 1978 is newer. There are numerous reasons that each of the four processes can occur (detailed in each article). Generally speaking, sources of acid gain include: Sources of acid loss include: The body's acid–base balance is tightly regulated. Several buffering agents exist which reversibly bind hydrogen ions and impede any change in