ABO blood group system roles in cell membrane integrity, cell adhesion, membrane transportation of molecules, and acting as receptors for extracellular ligands, and enzymes. ABO antigens are found having similar roles on epithelial cells as well as red blood cells. The ABO antigen is also expressed on the von Willebrand factor (vWF) glycoprotein, which participates in hemostasis (control of bleeding). In fact, having type O blood predisposes to bleeding, as 30% of the total genetic variation observed in plasma vWF is explained by the effect of the ABO blood group, and individuals with group O blood normally have significantly lower plasma levels of vWF
Blood type personality theory methodology of his conclusions was unclear. Because of this, he was heavily criticized by the Japanese psychological community, although his books remain popular. His son, Toshitaka Nomi, continued to promote the theory with a series of books and by running the Institute of Blood Type Humanics. He later established the Human Science ABO Center for further research and publication in 2004. Some researchers believe blood types are associated with personality traits. Many medical surveys have been conducted, such as those for hormone secretion traits (DBH, COMT, MAO etc.), or the blood-type antigens in neurons, or the antigens expressed on surfaces