The Unselfish Gene of the novel is a nod to Richard Dawkins' 1976 book, "The Selfish Gene". Among the concepts developed in Dawkins' book is a theory of how natural selection may favor self-sacrifice and other forms of altruism. The themes of altruism and small gene sets play an important role in plot and character development in The Unselfish Gene. The Unselfish Gene is what might be termed "semi-hard" science fiction. The technology described in the book is well within the limits of early 21st century technology. Some of it, such as "The Anita", an atomic-bomb powered heavy lifter space ship, was actually
The Genetical Theory of Natural Selection wrote that it was "certain to take rank as one of the major contributions to the theory of evolution." J. B. S. Haldane described it as "brilliant." Reginald Punnett was negative, however. The book was largely overlooked for 40 years, and in particular Fisher's fundamental theorem of natural selection was misunderstood. The work had a great effect on W. D. Hamilton, who discovered it as an undergraduate at the University of Cambridge and noted in these excerpts from the rear cover of the 1999 variorum edition: The publication of the variorum edition in 1999 led to renewed interest in the