Catgut suture treatment produces roughly twice the stitch-holding time of plain catgut, but greater tissue inflammation occurs. Full tensile strength is extended to 18–21 days. It is brown rather than straw-colored, and has improved smoothness due to the dry presentation of the thread (plain catgut is wet). It is otherwise similar to plain catgut. Fast catgut suture is heat-treated to give even more rapid absorption in the body. The first known absorbable sutures were made of the intestines of sheep. The manufacturing process was similar to that of natural musical strings for violins and guitar, and also of natural strings for tennis
Catgut suture anemia, and malnutrition. It also absorbed faster when used in the mouth and the vagina, due to the presence of microorganisms. Catgut has largely been replaced by synthetic absorbable polymers such as Vicryl and polydioxanone. It is not used at all for human surgery in some countries. In Europe and Japan, gut sutures have been banned due to concerns that they could transmit bovine spongiform encephalopathy (mad-cow disease), although the herds from which gut is harvested are certified BSE-free. Catgut suture is made by twisting together strands of purified collagen taken from the serosal or submucosal layer of the small