Pleiotropy correlations and responses to selection most often exemplify pleiotropy. Pleiotropic traits had been previously recognized in the scientific community but had not been experimented on until Gregor Mendel's 1866 pea plant experiment. Mendel recognized that certain pea plant traits (seed coat color, flower color, and axial spots) seemed to be inherited together; however, their correlation to a single gene has never been proven. The term "pleiotropie" was first coined by Ludwig Plate in his Festschrift, which was published in 1910. He originally defined pleiotropy as occurring when "several characteristics are dependent upon ... [inheritance]; these characteristics will then always appear
History of model organisms respective work on natural selection and the genetics of heredity. These early works in finding standards to compare organisms against continued into the 20th century as the first model organisms were brought into laboratories. Beginning in the early 1900s "Drosophila" entered the research laboratories and opened up the doors for other model organisms like Tobacco mosaic virus, E. coli, C57BL/6 (lab mice), etc. These organisms have led to many advances in the past century. Some of the first work with what would be considered model organisms started because Gregor Johann Mendel felt that the views of Darwin were insufficient in