The Unselfish Gene of the novel is a nod to Richard Dawkins' 1976 book, "The Selfish Gene". Among the concepts developed in Dawkins' book is a theory of how natural selection may favor self-sacrifice and other forms of altruism. The themes of altruism and small gene sets play an important role in plot and character development in The Unselfish Gene. The Unselfish Gene is what might be termed "semi-hard" science fiction. The technology described in the book is well within the limits of early 21st century technology. Some of it, such as "The Anita", an atomic-bomb powered heavy lifter space ship, was actually
The Selfish Gene in which Dawkins describes the continued relevance of the gene's eye view of evolution and states that it, along with coalescence analysis "illuminates the deep past in ways of which I had no inkling when I first wrote "The Selfish Gene"..." In April 2016, "The Selfish Gene" was listed as number 10 on "The Guardian"'s list of the 100 best nonfiction books, by Robert McCrum. In July 2017, the book was listed as the most influential science book of all time in a poll to celebrate the 30th anniversary of the Royal Society science book prize, ahead of Charles Darwin's