Transgender hormone therapy (male-to-female) hair becomes more typically female in pattern. Lower leg hair becomes less dense. All of these changes depend to some degree on genetics. Head hair may change slightly in texture, curl, and color. This is especially likely with hair growth from previously bald areas. Eyebrows do not change because they are not androgenic. The lens of the eye changes in curvature. Because of decreased androgen levels, the meibomian glands (the sebaceous glands on the upper and lower eyelids that open up at the edges) produce less oil. Because oil prevents the tear film from evaporating, this change may cause dry
Dental sealant that resin could be bonded to enamel through acid etching, increasing adhesion whilst also creating an improved marginal integrity of resin restorative material. It was this bonding system that lead to the future successful creation of fissure sealants. In 1966, E.I. Cueto created the first sealant material, which was methyl cyanoacrylate. However, this material was susceptible to bacterial breakdown over time, therefore was not an acceptable sealing material. Bunonocore made further advances in 1970 by developing bisphenol-a glycidyl dimethacrylate, which is a viscous resin commonly known as BIS-GMA. This material was used as the basis for many resin-based sealant/composite material