Paris in the 16th century include the Tuileries Palace, the Fontaine des Innocents, the Lescot wing of the Louvre; the church of Saint-Eustache (1532); and the Hôtel Carnavalet, begun in 1545, now the museum of the history of Paris. During the century Paris was the second most important center of book publishing centers of Europe, after Venice. The University of Paris devoted its attentions largely to fighting the Protestant heresy, the King founded the College of France as a new center of learning independent of the university. Tensions between Protestants and Catholics grew, culminating in the St. Bartholomew's Day massacre in 1572, when several thousand
St. Bartholomew's Day massacre 18th-century historian Louis-Pierre Anquetil, in his "Esprit de la Ligue" of 1767, was among the first to begin impartial historical investigation, emphasizing the lack of premeditation (before the attempt on Coligny) in the massacre and that Catholic mob violence had a history of uncontrollable escalation. By this period the Massacre was being widely used by Voltaire (in his "Henriade") and other Enlightenment writers in polemics against organized religion in general. The question of whether the massacre had long been premeditated was not entirely settled until the late 19th century; Lord Acton changed his mind on the matter twice, finally concluding