Paris in the 16th century on September 5, 1557, thirty were from noble families. In 1561-62, the number of Protestants in Paris was estimated at between ten and fifteen thousand; in France as a whole, three million, or fifteen percent of the population. The Massacre of Saint-Bartholomew's Day on August 23–24, 1572 killed between two and three thousand Protestants; it was followed by a large-scale emigration of Protestants out of the city, primarily to Sedan, Montbeliard and Geneva. In 1598, with the Edict of Nantes, the Protestant were again able to open a church a Grigny, on the banks of the Seine outside the city.
16th century in North American history of Liébault whose work had hitherto been the chief source of information on the subject in Europe. Monardes made tobacco a household remedy throughout Western Europe and his gospel was accepted by the majority of European physicians for more than two centuries. Nowhere does he write of tobacco smoked by white men for pleasure 16th century in North American history The historical record in North America begins in the second half of the 16th century, with ongoing European exploration. Giovanni da Verrazzano explored the East Coast of North America from Florida to presumably Newfoundland in 1524. Jacques Cartier made a