Catgut suture treatment produces roughly twice the stitch-holding time of plain catgut, but greater tissue inflammation occurs. Full tensile strength is extended to 18–21 days. It is brown rather than straw-colored, and has improved smoothness due to the dry presentation of the thread (plain catgut is wet). It is otherwise similar to plain catgut. Fast catgut suture is heat-treated to give even more rapid absorption in the body. The first known absorbable sutures were made of the intestines of sheep. The manufacturing process was similar to that of natural musical strings for violins and guitar, and also of natural strings for tennis
Musical instrument been used to play four notes of a diatonic scale. Researchers estimate the flute's age at between 43,400 and 67,000 years, making it the oldest known musical instrument and the only musical instrument associated with the Neanderthal culture. However, some archaeologists and ethnomusicologists dispute the flute's status as a musical instrument. German archaeologists have found mammoth bone and swan bone flutes dating back to 30,000 to 37,000 years old in the Swabian Alps. The flutes were made in the Upper Paleolithic age, and are more commonly accepted as being the oldest known musical instruments. Archaeological evidence of musical instruments was