Biodegradable polymer which, edible films have gained more attention due to their environmentally-friendly characteristics, vast variety and availability, non-toxicity, and low cost. Biodegradable polymers have a long history, and since many are natural products, the precise timeline of their discovery and use cannot be accurately traced. One of the first medicinal uses of a biodegradable polymer was the catgut suture, which dates back to at least 100 AD. The first catgut sutures were made from the intestines of sheep, but modern catgut sutures are made from purified collagen extracted from the small intestines of cattle, sheep, or goats. The concept of synthetic
Musical instrument been used to play four notes of a diatonic scale. Researchers estimate the flute's age at between 43,400 and 67,000 years, making it the oldest known musical instrument and the only musical instrument associated with the Neanderthal culture. However, some archaeologists and ethnomusicologists dispute the flute's status as a musical instrument. German archaeologists have found mammoth bone and swan bone flutes dating back to 30,000 to 37,000 years old in the Swabian Alps. The flutes were made in the Upper Paleolithic age, and are more commonly accepted as being the oldest known musical instruments. Archaeological evidence of musical instruments was