Hot sauce - with one of the mildest commercially available condiments, Cackalacky Classic Condiment Company's Spice Sauce, weighing in at less than 1000 Scoville units on the standard heat scale. A general way to estimate the heat of a sauce is to look at the ingredients list. Sauces tend to vary in heat based on the kind of peppers used, and the further down the list, the less the amount of pepper. Capsaicinoids are the chemicals responsible for the "hot" taste of chili peppers. They are fat soluble and therefore water will be of no assistance when countering the burn. The most
Scoville scale mouth heat receptors, which vary widely among people. Another weakness is sensory fatigue; the palate is quickly desensitized to capsaicinoids after tasting a few samples within a short time period. Results vary widely (up to ± 50%) between laboratories. Since the 1980s, spice heat has been assessed quantitatively by HPLC, which measures the concentration of heat-producing capsaicinoids, typically with capsaicin content as the main measure. As stated in one review: "the most reliable, rapid, and efficient method to identify and quantify capsaicinoids is high-performance liquid chromatography (HPLC); the results of which can be converted to Scoville Heat Units by multiplying