Pleiotropy correlations and responses to selection most often exemplify pleiotropy. Pleiotropic traits had been previously recognized in the scientific community but had not been experimented on until Gregor Mendel's 1866 pea plant experiment. Mendel recognized that certain pea plant traits (seed coat color, flower color, and axial spots) seemed to be inherited together; however, their correlation to a single gene has never been proven. The term "pleiotropie" was first coined by Ludwig Plate in his Festschrift, which was published in 1910. He originally defined pleiotropy as occurring when "several characteristics are dependent upon ... [inheritance]; these characteristics will then always appear
History of science place in the universe". In the early 20th century, the study of heredity became a major investigation after the rediscovery in 1900 of the laws of inheritance developed by the Moravian monk Gregor Mendel in 1866. Mendel's laws provided the beginnings of the study of genetics, which became a major field of research for both scientific and industrial research. By 1953, James D. Watson, Francis Crick and Maurice Wilkins clarified the basic structure of DNA, the genetic material for expressing life in all its forms. In the late 20th century, the possibilities of genetic engineering became practical for the first