Pleiotropy correlations and responses to selection most often exemplify pleiotropy. Pleiotropic traits had been previously recognized in the scientific community but had not been experimented on until Gregor Mendel's 1866 pea plant experiment. Mendel recognized that certain pea plant traits (seed coat color, flower color, and axial spots) seemed to be inherited together; however, their correlation to a single gene has never been proven. The term "pleiotropie" was first coined by Ludwig Plate in his Festschrift, which was published in 1910. He originally defined pleiotropy as occurring when "several characteristics are dependent upon ... [inheritance]; these characteristics will then always appear
Genetics and the Origin of Species that give them a competitive advantage, and they have the best chance of surviving and procreating. The main element lacking in the theory was any mechanism that would allow organisms to pass on these favorable variations. Lacking such a mechanism, the theory of evolution faced competition from theories such as neo-Lamarckism, in which the environment acted directly on organisms, changing their structures. Darwin did not know that the monk Gregor Mendel was already working on experiments that would explain inheritance in terms of units of heredity that we now call genes. When Mendelian genetics was rediscovered by several scientists, it