Penny-farthing term and "hi-wheel" (and variants) are preferred by many modern enthusiasts. Following the popularity of the boneshaker, Eugène Meyer, a Frenchman, invented the high-wheeler bicycle design in 1869 and fashioned the wire-spoke tension wheel. Around 1870 English inventor James Starley, described as the father of the bicycle industry, and others, began producing bicycles based on the French boneshaker but with front wheels of increasing size, because larger front wheels, up to in diameter, enabled higher speeds on bicycles limited to direct drive. In 1878, Albert Pope began manufacturing the Columbia bicycle outside Boston, starting their two-decade heyday in America. Although
Urs A. Meyer to the molecular mechanism by which drugs activate transcription factors such as nuclear receptors and thereby regulate the expression of drug metabolizing enzymes and drug transporters. Urs A. Meyer Urs Albert Meyer is a Swiss physician-scientist and clinical pharmacologist. Meyer is professor emeritus of pharmacology. He obtained his M.D. at the University of Zurich in 1967 and worked as assistant professor in clinical pharmacology at the University of California, San Francisco. In 1974, he became Head of Clinical Pharmacology at the University Hospital of Zurich. From 1983 to 2008, Meyer carried out research and taught as professor of pharmacology at