Meibomian gland been shown to reduce inflammation and improve the gland function in patients. Meibomian gland probing is also used on patients which experience deep clogging of the glands. Meibomian gland dysfunction may be caused by some prescription medications, notably isotretinoin. Meibomian gland The Meibomian glands (often written with a small "m" and also called tarsal glands) are a holocrine type of exocrine glands, at the rim of the eyelids inside the tarsal plate, responsible for the supply of meibum, an oily substance that prevents evaporation of the eye's tear film. Meibum prevents tear spillage onto the cheek, trapping tears between the
Isotretinoin in young people who are still growing. Premature epiphyseal closure can occur in people with acne receiving recommended doses of Accutane. Isotretinoin is known to cause meibomian gland dysfunction which causes persistent keratoconjunctivitis sicca (dry eye). Problems with the meibomian and salivary glands are likely due to the non-selective apoptosis of the cells of the exocrine glands. Decreased night vision has been reported to persist in some people after discontinuation of isotretinoin therapy. The most common side effects are mucocutaneous: dry lips, skin and nose. Other common mucocutaneous side effects are inflammation and chapping of the lips (cheilitis), redness of