Modern synthesis (20th century) a gene-centred view of evolution following Hamilton's concepts, disputing the idea of evolutionary progress, and attacking the then widespread theory of group selection. Williams argued that natural selection worked by changing the frequency of alleles, and could not work at the level of groups. Gene-centred evolution was popularised by Richard Dawkins in his 1976 book "The Selfish Gene" and developed in his more technical writings. In 1975, E. O. Wilson published his controversial book "", the subtitle alluding to the modern synthesis as he attempted to bring the study of animal society into the evolutionary fold. This appeared radically new,
On the Tendency of Species to form Varieties; and on the Perpetuation of Varieties and Species by Natural Means of Selection Letter" from Darwin to Asa Gray. This was the first announcement of the Darwin – Wallace theory of evolution by natural selection; the papers appeared in print on 20 August 1858. The presentation of the papers spurred Darwin to write a condensed "abstract" of his "big book" on "Natural Selection". This was published in November 1859 as "On the Origin of Species". On the voyage of the "Beagle" the young Charles Darwin took a break between graduating and starting his career as a clergyman to study the natural history of South America, an interest he had developed at the University