Grand Erg Oriental small but ancient settlement of Ghadames at the Libyan frontier. Another and better road from Hassi Messaoud goes south, also crossing the grand erg where it passes a well called "Hassi Tartrat", before reaching the erg's far side. Further south lies the Ahaggar mountains. The cities of Wargla and Touggourt lie outside the western limits of the erg. Nearby, within the accepted boundaries of the "Grand Erg Oriental", the landscape is described as being "practically free from [sand] dunes" evidently due to strong, persistent winds. Petroleum and other hydrocarbons have been extracted in Algeria, from areas in and surrounding the
ERG (gene) TLS/FUS in Ewing's sarcoma and acute myeloid leukemias respectively and function as transcriptional activators. ERG and its fusion proteins EWS-ERG and TLS/FUS-ERG inhibit apoptosis. "ERG" can fuse with TMPRSS2 protein to form an oncogenic fusion gene that is commonly found in human prostate cancer, especially in hormone-refractory prostate cancer. This suggests that "ERG" overexpression may contribute to development of androgen-independence in prostate cancer through disruption of androgen receptor signaling. The fusion gene is critical to the progression of cancer because it inhibits the androgen receptor expression and it binds and inhibits androgen receptors already present in the cell. Essentially TMPRSS2-ERG