Pencil thereby pushing a new tip to the top. Invented by Harold Grossman for Empire Pencil Company in 1967 and subsequently improved upon by Arthur D. Little for Empire from 1969 through the early 1970s; the plastic pencil was commercialised by Empire as the "EPCON" Pencil. These pencils were co-extruded, extruding a plasticised graphite mix within a wood-composite core. Residual graphite from a pencil stick is not poisonous, and graphite is harmless if consumed. Although lead has not been used for writing since antiquity, lead poisoning from pencils was not uncommon. Until the middle of the 20th century the paint used
Lead poisoning affected by lead toxicity to varying degrees depending on species. Animals experience many of the same effects of lead exposure as humans do, such as abdominal pain, peripheral neuropathy, and behavioral changes such as increased aggression. Much of what is known about human lead toxicity and its effects is derived from animal studies. Animals are used to test the effects of treatments, such as chelating agents, and to provide information on the pathophysiology of lead, such as how it is absorbed and distributed in the body. Farm animals such as cows and horses as well as pet animals are also