Galena, Alaska located on the Yukon River between the Koyukuk River and the Nowitna River. Galena was established in 1918 near an Athabascan fish camp called Henry's Point. It became a supply and point for nearby lead ore mines that opened in 1918 and 1919. In 1941 and 1942, during World War II, a military air field was built adjacent to the civilian airport, and the two facilities shared the runway and flight line facilities. This air field was designated Galena Air Force Station shortly after the split of the United States Air Force from the United States Army, which occurred as
Galena, Alaska in the few last remaining dry parts of town. The flood dike the Air Force built around the runway managed to keep the river from inundating the runway and GILA. Efforts are currently underway to help Galena rebuild, with the assistance of the Federal Emergency Management Agency and volunteer groups. Galena is located at (64.740643, -156.885462). Galena is located on the north bank of the Yukon River, east of Nulato. The Innoko National Wildlife Refuge is southwest of Galena. According to the United States Census Bureau, the city has a total area of , of which, of it is land