Galena cubic unit cell much like the mineral halite of the halide mineral group. Zinc, cadmium, iron, copper, antimony, arsenic, bismuth and selenium also occur in variable amounts in galena. Selenium substitutes for sulfur in the structure constituting a solid solution series. The lead telluride mineral altaite has the same crystal structure as galena. Within the weathering or oxidation zone galena alters to anglesite (lead sulfate) or cerussite (lead carbonate). Galena exposed to acid mine drainage can be oxidized to anglesite by naturally occurring bacteria and archaea, in a process similar to bioleaching. One of the oldest uses of galena was
Mineral processing is not completely known and further research into their mechanisms is being performed. Depressants and activators are used to selectively separate one mineral from another. Depressants inhibit the flotation of one mineral or minerals while activators enable the flotation of others. Examples of these include CN, used to depress all sulfides but galena and this depressant is believed to operate by changing the solubility of chemisorbed and physisorbed collectors on sulfides. This theory originates from Russia. An example of an activator is Cu ions, used for the flotation of sphalerite. There are a number of cells able to be used