Paris in the 16th century Wars of Religion (1562-1598). Paris was the stronghold of the Catholic League. On the night of August 23–24, 1572, while many prominent Protestants from all over France were in Paris on the occasion of the marriage of Henri of Navarre—the future Henry IV—to Margaret of Valois, sister of Charles IX, the royal council decided to assassinate the leaders of the Protestants. The targeted killings quickly turned into a general slaughter of Protestants by Catholic mobs, known as St. Bartholomew's Day massacre, and continued through August and September, spreading from Paris to the rest of the country. About three thousand Protestants
Paris in the 16th century Paris is estimated by modern historians to have been about 250,000 at the beginning of the 16th century, growing to 350,000 by 1550, then dropping down to 300,000 by the end of the century, due to the plague epidemic of 1580, and the long siege of the city during the Wars of Religion. The area of the city covered about 439 hectares within the city walls. Several new neighborhoods, formally rural, were populated over the course of the century, notably the Faubourgs Saint-Honoré, Saint-Martin, and Montmartre. Despite efforts of the government to keep the area outside of the walls clear