Wilbur Scoville was first published in 1895 and has gone through at least 8 editions. The book was used as a pharmacological reference up until the 1960s. Scoville also wrote "Extracts and Perfumes", which contained hundreds of formulations. For a time he was a professor at the Massachusetts College of Pharmacy and Health Sciences. In 1912, he devised the test and scale known as the "Scoville Organoleptic Test" while working at the Parke-Davis pharmaceutical company. It measured piquancy, or "spiciness", of various chili peppers. It is now standardized as the Scoville scale. In 1922, Scoville won the Ebert prize from the American
Scoville scale mouth heat receptors, which vary widely among people. Another weakness is sensory fatigue; the palate is quickly desensitized to capsaicinoids after tasting a few samples within a short time period. Results vary widely (up to ± 50%) between laboratories. Since the 1980s, spice heat has been assessed quantitatively by HPLC, which measures the concentration of heat-producing capsaicinoids, typically with capsaicin content as the main measure. As stated in one review: "the most reliable, rapid, and efficient method to identify and quantify capsaicinoids is high-performance liquid chromatography (HPLC); the results of which can be converted to Scoville Heat Units by multiplying