The Unselfish Gene of the novel is a nod to Richard Dawkins' 1976 book, "The Selfish Gene". Among the concepts developed in Dawkins' book is a theory of how natural selection may favor self-sacrifice and other forms of altruism. The themes of altruism and small gene sets play an important role in plot and character development in The Unselfish Gene. The Unselfish Gene is what might be termed "semi-hard" science fiction. The technology described in the book is well within the limits of early 21st century technology. Some of it, such as "The Anita", an atomic-bomb powered heavy lifter space ship, was actually
The Genetical Theory of Natural Selection cited in biology books, outlining many concepts that are still considered important such as Fisherian runaway, Fisher's principle, reproductive value, Fisher's fundamental theorem of natural selection, Fisher's geometric model, the sexy son hypothesis, mimicry and the evolution of dominance. It was dictated to his wife in the evenings as he worked at Rothamsted Research in the day. In the preface, Fisher considers some general points, including that there must be an understanding of natural selection distinct from that of evolution, and that the then-recent advances in the field of genetics (see history of genetics) now allowed this. In the first