Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Public sphere that are "parallel discursive arenas where members of subordinated social groups invent and circulate counterdiscourses to formulate oppositional interpretations of their identities, interests, and needs". Benhabib notes that in Habermas' idea of the public sphere, the distinction between public and private issues separates issues that normally affect women (issues of "reproduction, nurture and care for the young, the sick, and the elderly") into the private realm and out of the discussion in the public sphere. She argues that if the public sphere is to be open to any discussion that affects the population, there cannot be distinctions between "what is"