Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
Fools Gold/What the World Is Waiting For and "What the World Is Waiting For" were recorded at Sawmills Studios in Cornwall during the late summer of 1989, with additional vocal and guitar parts recorded later at London's Battery Studios, during the autumn of 1989. The tracks had been worked on for four months, and the intention was to put "What the World Is Waiting For" as the A side; however, when Roddy Mckenna, Silvertone's A&R man, heard "Fools Gold" he urged the band to use that as the A-side. The band were not completely convinced, and it was agreed, instead, to release the two tracks as a