Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Unit sphere to a metric space, with respect to a chosen origin. However, topological considerations (interior, closure, border) need not apply in the same way (e.g., in ultrametric spaces, all of the three are simultaneously open and closed sets), and the unit sphere may even be empty in some metric spaces. If "V" is a linear space with a real quadratic form "F":"V" → R, then { p ∈ "V" : "F"(p) = 1 } may be called the unit sphere or unit quasi-sphere of "V". For example, the quadratic form formula_29, when set equal to one, produces the unit hyperbola which