Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere a ball is called the specific surface area and can be expressed from the above stated equations as where is the density (the ratio of mass to volume). A sphere is uniquely determined by four points that are not coplanar. More generally, a sphere is uniquely determined by four conditions such as passing through a point, being tangent to a plane, etc. This property is analogous to the property that three non-collinear points determine a unique circle in a plane. Consequently, a sphere is uniquely determined by (that is, passes through) a circle and a point not in the plane