Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Sphere of annihilation "sphere of annihilation" remains in place, but a character can move it through mental effort. Mordicai Knode of Tor.com called the item "the best minor artifact" in the game. Sphere of annihilation A sphere of annihilation is a fictional magic item in the "Dungeons & Dragons" fantasy role-playing game. The sphere of annihilation appeared in first edition "Advanced Dungeons & Dragons" in the original 1979 "Dungeon Master's Guide". It also appeared in second edition "Advanced Dungeons & Dragons" in the 2nd edition "Dungeon Master's Guide" (1989). The sphere of annihilation appeared in the third edition "Dungeon Master's Guide" (2000), classified