Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Science On a Sphere runs on Linux. SOS was invented by Alexander E. MacDonald, the former director of the National Oceanographic and Atmospheric Administration (NOAA) Earth System Research Laboratory in Boulder, CO, and OAR Deputy Assistant Administrator for the NOAA Research Laboratories and Cooperative Institutes. MacDonald devised the original idea for Science On a Sphere in 1995 as part of other data visualization work he oversaw in what was the former NOAA Forecast Systems Laboratory. A small but highly motivated and inventive team of NOAA staff led by chief designer David Himes wrote the SOS software and developed the SOS hardware and system architecture.