Beaver extinction in part for the production of castoreum, which was used as an analgesic, anti-inflammatory, and antipyretic. Castoreum was described in the 1911 British Pharmaceutical Codex for use in dysmenorrhea and hysterical conditions (i.e. pertaining to the womb), for raising blood pressure and increasing cardiac output. The activity of castoreum has been credited to the accumulation of salicin from willow trees in the beaver's diet, which is transformed to salicylic acid and has an action very similar to aspirin. Castoreum continues to be used in perfume production. Castoreum can be used as an enhancer of vanilla, strawberry and raspberry flavorings.
Ground substance as hyaluronic acid, heparan sulfate, dermatan sulfate, and chondroitin sulfate, proteoglycans which GAGs are bound to, and glycoproteins. Components of the ground substance are secreted by fibroblasts. Usually it is not visible on slides, because it is lost during staining in the preparation process. Link proteins such as vinculin, spectrin and actomyosin stabilize the proteoglycans and organize elastic fibers in the ECM. Changes in the density of ground substance can allow collagen fibers to form aberrant cross-links. Loose connective tissue is characterized by few fibers and cells, and a relatively large amount of ground substance. Dense connective tissue has a