Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Public sphere and "what is not" discussed. Benhabib argues for feminists to counter the popular public discourse in their own counter public. The public sphere was long regarded as men's domain whereas women were supposed to inhabit the private domestic sphere. A distinct ideology that prescribed separate spheres for women and men emerged during the industrial revolution. The concept of heteronormativity is used to describe the way in which those who fall outside of the basic male/female dichotomy of gender or whose sexual orientations are other than heterosexual cannot meaningfully claim their identities, causing a disconnect between their public selves and their