Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Science On a Sphere This work enabled MacDonald's invention to move out from the laboratory and into performance spaces. A patent was awarded to NOAA for Science On a Sphere in August 2005, with MacDonald credited as the inventor. General system architecture and configuration specifications are as follows. The carbon fiber sphere is in diameter. Other sphere sizes are possible, such as 48" and 60". Larger sizes are possible too. The 68" sphere with a single seam at the equator weighs under . The sphere is attached to the ceiling or suspension structure with a three-point suspension system to hold the sphere in place