Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
What Is a Nation? to the reasons based on race, geography, history and so on. They argue that Renan maintains his intellectual background but subtly, i.e. the arguments he explicitly used in "What is a Nation?" are not consistent with his thinking. The concept of "daily plebiscite" would be ambiguous. They argue that the definition is an opportunist idealization and it should be interpreted within the Franco-Prussian War and in the midst of the dispute concerning the Alsace-Lorraine region. What Is a Nation? "What is a Nation?" ("Qu'est-ce qu'une nation?") is an 1882 lecture by French historian Ernest Renan (1823–1892), known for the statements