Salicylaldehyde be prepared from the corresponding phenol by the Duff reaction, or by treatment with paraformaldehyde in the presence of magnesium chloride and a base. Salicylaldehyde was identified as a characteristic aroma component of buckwheat. It is also one of the components of castoreum, the exudate from the castor sacs of the mature North American beaver ("Castor canadensis") and the European beaver ("Castor fiber"), used in perfumery. Furthermore, salicylaldehyde occurs in the larval defensive secretions of several leaf beetle species that belong the subtribe Chrysomelina. An example for a leaf beetle species that produces salicylaldehyde is the red poplar leaf beetle
Biomarker (medicine) Biomarker (medicine) In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state. More generally a biomarker is anything that can be used as an indicator of a particular disease state or some other physiological state of an organism. A biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. For example, rubidium chloride is used in isotopic labeling to evaluate perfusion of heart muscle. It can also be a substance whose detection indicates a particular disease state, for example, the