Drug injection can lead to a dependency by both physical and psychological means — and develops more quickly than with other methods of taking drugs. In recreational-use drug culture, preparation may include mixing the powdered drug with water to create an aqueous solution, and then the solution is injected. This act is often colloquially referred to as "slamming", "shooting [up]", “smashing”, "banging", "pinning", or "jacking-up", often depending on the specific drug subculture in which the term is used (i.e. heroin, cocaine, or methamphetamine). There are a variety of reasons why drugs would be more attractive to inject rather than take through other
Drug Price Competition and Patent Term Restoration Act the generic company is preparing its ANDA – during that time the generic company needs to learn how to manufacture the drug, manufacture a test batch, and run bioequivalence studies with it, which are all activities that it could be sued for infringement for. This protection is called the "research exemption". When a company is ready to file its ANDA, the Act requires it to declare how its activities when it begins to market the drug will relate to patents listed in the Orange Book; there are four options or "certifications": it can state that there never were patents listed,