Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Core sphere approximately 30% of the total product. Long before the Industrial Revolution, the core sphere was the entire economy. Families and communities provided for themselves by hunting and gathering. Then with industrialization came a market of competitive men working for wages and along with it what historians call the cult of domesticity. The core sphere became regarded not as part of the market sphere of the economy but more as emotional and altruistic behavior. Therefore, activities in the core sphere were not considered economic because they do not directly influence the market economy. As time has progressed towards the present, organizations