Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere (novel) film by Andrei Tarkovsky". Reviews were mostly positive for the novel. "The New York Times" Robin McKinley said, "Part of the fun of "Sphere" is that it keeps you going even when you're pretty sure of what will happen next." Sphere (novel) Sphere is a novel written by author Michael Crichton that was published in 1987. The novel was adapted into the film "Sphere" in 1998. The story follows Norman Johnson, a psychologist engaged by the United States Navy, who joins a team of scientists assembled to examine a spacecraft of unknown origin discovered on the bottom of the Pacific