Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
A Girl Is a Half-formed Thing A Girl Is a Half-formed Thing A Girl Is a Half-formed Thing is the debut novel of Eimear McBride. This stream of consciousness novel explores an Irish girl's relationship with her disabled brother, religious mother, and her own troubled sexuality. Joshua Cohen described how McBride's experimental style "forgoes quotation marks and elides verbiage for sense, sound and sheer appearance on the page. For emphasis it occasionally wreaks havoc on capItalS and reverses letter order." McBride began writing her debut novel whilst working in a series of office temp jobs. It took nine years to find a publisher and was rejected