Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Unit sphere surface of what is commonly called a "circle", while such a circle's interior and surface together are the two-dimensional ball. Similarly, a two-dimensional sphere is the surface of the Euclidean solid known colloquially as a "sphere", while the interior and surface together are the three-dimensional ball. A unit sphere is simply a sphere of radius one. The importance of the unit sphere is that any sphere can be transformed to a unit sphere by a combination of translation and scaling. In this way the properties of spheres in general can be reduced to the study of the unit sphere. In