Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Circle of a sphere Circle of a sphere A circle of a sphere is a circle that lies on a sphere. Such a circle can be formed as the intersection of a sphere and a plane, or of two spheres. A circle on a sphere whose plane passes through the center of the sphere is called a great circle; otherwise it is a small circle. Circles of a sphere have radius less than or equal to the sphere radius, with equality when the circle is a great circle. In the geographic coordinate system on a globe, the parallels of latitude are such circles, with