Drug injection taking drugs, injection is favoured by some people as the full effects of the drug are experienced very quickly, typically in five to ten seconds. It also bypasses first-pass metabolism in the liver, resulting in higher bioavailability and efficiency for many drugs (such as morphine or diacetylmorphine/heroin; roughly two-thirds of which is destroyed in the liver when consumed orally) than oral ingestion would. The effect is that the person gets a stronger (yet shorter-acting) effect from the same amount of the drug. Drug injection is therefore often related to substance dependence. In a recreational context, the shorter, more intense "high"
Arguments for and against drug prohibition a drug and the signal sent out and there is, therefore, no evidence base on which to draw in making these policy decisions." John Donnelly, writing for the Boston Globe on the presidential race of 2000, suggested that the candidates' silence on drug policy may stem from a widely shared belief that any position even hinting at reducing penalties for drug use would be political suicide. Charles R. Schuster, director of the National Institute on Drug Abuse under Presidents Reagan and Bush (Snr.), was reported as saying in 1997, "Talking sense about drug policy in today's climate of opinion can