PH a pH of 7.3. This is clearly wrong as an acid solution should have a pH of less than 7. Treating the system as a mixture of hydrochloric acid and the amphoteric substance water, a pH of 6.89 results. A weak acid or the conjugate acid of a weak base can be treated using the same formalism. First, an acid dissociation constant is defined as follows. Electrical charges are omitted from subsequent equations for the sake of generality and its value is assumed to have been determined by experiment. This being so, there are three unknown concentrations, [HA], [H] and
Acid sphingomyelinase Acid sphingomyelinase Acid sphingomyelinase is one of the enzymes that make up the sphingomyelinase (SMase) family, responsible for catalyzing the breakdown of sphingomyelin to ceramide and phosphorylcholine. They are organized into alkaline, neutral, and acidic SMase depending on the pH in which their enzymatic activity is optimal. Acid Sphingomyelinases (aSMases) enzymatic activity can be influenced by lipids, cations, pH, redox and other proteins in the environment. Specifically aSMases have been shown to have increased enzymatic activity in lysobisphophatidic acid (LBPA) or phosphatidylinositol (PI) enriched environments, and inhibited activity when phosphorylated derivatives of PI are present. Sphingomyelin phosphodiesterase 1 [SMPD1] is