Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Animal welfare exhibit normal behavior patterns, to be housed with, or apart from, other animals (if applicable), and to be protected from pain, injury, suffering and disease. Anyone who is cruel to an animal, or does not provide for its welfare needs, may be banned from owning animals, fined up to £20,000 and/or sent to prison for a maximum of six months. In the UK, the welfare of research animals being used for "regulated procedures" was historically protected by the Animals (Scientific Procedures) Act 1986 (ASPA) which is administrated by the Home Office. The Act defines "regulated procedures" as animal experiments that