Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
The Treatment Trap The Treatment Trap The Treatment Trap - How the Overuse of Medical Care is Wrecking your Health and what you can do to Prevent it is a 2010 book by Rosemary Gibson and Janardan Prasad Singh about unnecessary health care. AARP described the book as an exploration of "the reasons why many physicians are overly cautious, incompetent, or under great pressure to produce revenues in a health care system that seems to encourage these practices". A magazine review said that the message of the book was that "When it comes to health care, more is not always better." A reviewer