Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
International Association for the Treatment of Sexual Offenders two people need to have a strong relationship in order for the offenders to trust the clinicians), break up and mechanistic treatment delivery. The goals of sexual offender treatment is to achieve a goal that the offender has been working toward, which most of the time the goal is to not reoffend. This can be achieved by giving them hope, gaining self-esteem, making goals, creating strong relationships, and also working with the offender regularly. When it comes to the general criminal population treatment focuses on risk, need, and responsivity. However, when applied to sexual offenders two problems are risk assessment