Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
A Girl Is a Half-formed Thing A Girl Is a Half-formed Thing A Girl Is a Half-formed Thing is the debut novel of Eimear McBride. This stream of consciousness novel explores an Irish girl's relationship with her disabled brother, religious mother, and her own troubled sexuality. Joshua Cohen described how McBride's experimental style "forgoes quotation marks and elides verbiage for sense, sound and sheer appearance on the page. For emphasis it occasionally wreaks havoc on capItalS and reverses letter order." McBride began writing her debut novel whilst working in a series of office temp jobs. It took nine years to find a publisher and was rejected