Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
Things Ain't What They Used to Be Be", "Blue Serge" and "Moon Mist". Jazz musician and historian Chris Tyle argues that most likely Mercer Ellington came up with the melody and his father then arranged the song for the band. The song is most often played as an instrumental. Lyrics were written by Ted Persons. Johnny Hodges played it first, in Hollywood on July 3, 1941. Duke Ellington played it for the film "Cabin in the Sky" (1943). Things Ain't What They Used to Be "Things Ain't What They Used to Be" is a 1942 jazz standard with music by Mercer Ellington and lyrics by Ted Persons.