Esophageal pH monitoring developed a dependable external reference electrode. Using this technique to monitor esophageal acid exposure patients for periods up to 24 hours, DeMeester and Johnson were able to identify the most important parameters of esophageal acid exposure, and they developed a composite pH score to quantify gastroesophageal reflux. The initial 24-hour pH studies required hospitalization until the introduction of microcircuits in the 1980s that allowed portable esophageal pH monitoring in an outpatient setting. Gastroesophageal reflux disease (GERD) is a common disease in western countries. In the United States, 7% of the population experiences heartburn daily and 44% at least once a
6TMS neutral amino acid transporter family multidrug efflux pump of the RND superfamily (TC #2.A.6.2)) and the "mar" regulon itself, and (3) MarB, a small protein of 71 amino acyl residues of unknown function. A periplasmic binding protein, MppA, essential for the uptake of the cell wall murein tripeptide, L-alanyl-γ-D-glutamyl-"meso"-diaminopimelate via the Opp permease, regulates "mar" regulon expression. Loss of MppA causes overproduction of MarA which activates "acrAB", causing pleiotropic drug resistance. MppA probably functions upstream of MarA in a signal transduction pathway that negatively controls expression of the "marRAB" operon. 6TMS neutral amino acid transporter family The 6TMS Neutral Amino Acid Transporter (NAAT) Family (TC#