Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere -sphere of unit radius centered at the origin is denoted and is often referred to as "the" -sphere. Note that the ordinary sphere is a 2-sphere, because it is a 2-dimensional surface (which is embedded in 3-dimensional space). The surface area of the unit ()-sphere is where is Euler's gamma function. Another expression for the surface area is and the volume is the surface area times or General recursive formulas also exist for the volume of an -ball. More generally, in a metric space , the sphere of center and radius is the set of points such that . If