Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
International Association for the Treatment of Sexual Offenders as those individuals who (1) access child pornography due to impulse without any specific sexual interest in children; (2) access child pornography to satisfy sexual fantasies but do not commit contact sex offenses; (3) make and handout child pornography just for financial gain and benefit; and (4) use the Internet to facilitate contact sex offenses. Sexual offenders create many challenges for treatment providers probation officers, and even just regular people in their community. Sexual offenders create challenges because the treatment providers and probation officers have to decide what care is best and what limitations are necessary for that specific individual