Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Bernal sphere optimum mass-efficiency at providing radiation shielding. O'Neill envisioned the next generation of space habitat as a larger version of "Island One". "Island Two" would be approximately 1800 meters in diameter, yielding an equatorial circumference of nearly six and a half kilometers (four miles). The size was driven by economics; the habitat was to be small enough to allow for efficient transportation within the habitat and large enough to support an efficient industrial base. Bernal sphere A Bernal sphere is a type of space habitat intended as a long-term home for permanent residents, first proposed in 1929 by John Desmond Bernal.