Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Inversion in a sphere Inversion in a sphere In geometry, inversion in a sphere is a transformation of Euclidean space that fixes the points of a sphere while sending the points inside of the sphere to the outside of the sphere, and vice versa. Intuitively, it "swaps the inside and outside" of the sphere while leaving the points on the sphere unchanged. Inversion is a conformal transformation, and is the basic operation of inversive geometry. Inversion in a sphere is most easily described using polar coordinates. Choose a system of affine coordinates so that the centre of the sphere is at the origin and