Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
The Old Blue Mayor She Ain't What She Used to Be The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the twenty-ninth season of the animated television series "The Simpsons", and the 624th episode of the series overall. It aired in the United States on Fox on November 12, 2017. The track of the old Springfield Monorail (from "Marge vs. the Monorail") is converted into a "sky park". At the official opening, Mayor Quimby turns on the electricity which causes the monorail car to activate and destroy the boardwalk, running down Sebastian Cobb