Kype and/or characteristics that could be of importance in inter- and intra-sexual evaluations of individual quality. The size of the kype is believed to determine male spawning frequency. The extinct sabertooth salmon, "Oncorhynchus rastrosus", was first named for its prominent premaxillary dentition. It possesses an enormous conical tooth on each premaxilla. There is no visible kype on the dentary, implying a different strategy for forming mate dominance. Kype A kype is a hook-like secondary sex characteristic which develops at the distal tip of the lower jaw in some male salmonids prior to the spawning season. The structure usually develops in the
Osteonecrosis of the jaw should be eliminated before bisphosphonate therapy is initiated in these patients to reduce the necessity of subsequent dentoalveolar surgery. The degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alendronate (Fosamax), for osteoporosis is uncertain and warrants careful monitoring. Patients taking dexamethasone and other glucocorticoids are at increased risk. Matrix metalloproteinase 2 may be a candidate gene for bisphosphonate-associated osteonecrosis of the jaw, since it is the only gene known to be associated with bone abnormalities and atrial fibrillation, both of which are side effects of bisphosphonates. Persons with ONJ may have either necrotic bone or bone