Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Public sphere pedagogy sphere pedagogy might alienate students and community members unaccustomed to this type of dialectic experience. In addition to its exclusionary nature, attention has also been called to Habermas' privileging of a hegemonic public sphere. Michael Warner argues that the bourgeois public sphere was structured to be affable to those privileged few who made up the powerful upperclass. While students participating in public sphere pedagogy application receive special training in their classrooms, the same is not necessarily true of community members who participate. This specialized student training draws two critiques. First, conceiving of public pedagogy as a form of instruction risks