Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
The Old Blue Mayor She Ain't What She Used to Be tonight, flock to Marge not because she’s clearly a better candidate and person than perennially elected, womanizing, cartoonishly corrupt Diamond Joe Quimby, but because resident political operative Lindsey Naegle convinces her to use Professor Frink’s micro-targeted campaigning." "The Old Blue Mayor She Ain't What She Used to Be" scored a 1.9 rating with a 7 share and was watched by 4.75 million people, making it Fox's highest rated show of the night. The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the