Mefloquine during the study. Mefloquine was the first Public-Private Venture (PPV) between the US Department of Defense and a pharmaceutical company. WRAIR transferred all its phase I and phase II clinical trial data to Hoffman LaRoche and Smith Kline. FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. The drug was first approved and sold on a commercial basis in Switzerland in 1985. However, mefloquine was not approved by the FDA for prophylactic use until 1989. This approval was based primarily on compliance, while safety and tolerability were overlooked. Because of
What is this Feeling? and new?/I felt the moment I laid eyes on you/My pulse is rushing/My head is reeling/My face is flushing/What is this feeling?/Fervid as a flame/Does it have a name?"). The irony comes in when phrases traditionally used for love songs are revealed to be expressing hate. When Galinda and Elphaba describe each other, Galinda complains about Elphaba being "utterly impossible to describe", while Elphaba simply calls Galinda "blonde". At the end of the song, Elphaba scares Galinda, by saying "Boo", with Galinda letting out a high-pitched squeal. What is this Feeling? "What is this Feeling?" is a song from the