Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Science On a Sphere This work enabled MacDonald's invention to move out from the laboratory and into performance spaces. A patent was awarded to NOAA for Science On a Sphere in August 2005, with MacDonald credited as the inventor. General system architecture and configuration specifications are as follows. The carbon fiber sphere is in diameter. Other sphere sizes are possible, such as 48" and 60". Larger sizes are possible too. The 68" sphere with a single seam at the equator weighs under . The sphere is attached to the ceiling or suspension structure with a three-point suspension system to hold the sphere in place