Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Private sphere of experiential knowledge and the world of the body – as against the (traditional) male preserves of public speech and theory. All the while, the public sphere of work, business, politics and ideas were increasingly opened up to female participation. Martin Heidegger argued that it is only in the private sphere that one can be one's authentic self, as opposed to the impersonal and identikit They of the public realm. Richard Sennett however opposed what he saw as the Romantic idealisation of the private realm of intimate relations, as opposed to the public sphere of action at a distance. Deleuze