Pigment pigment derived from a parasitic insect found in Central and South America—attained great status and value in Europe. Produced from harvested, dried, and crushed cochineal insects, carmine could be—and still is—used in fabric dye, food dye, body paint, or—in its solid lake form—almost any kind of paint or cosmetic. According to Diana Magaloni, the Florentine Codex contains a variety of illustrations with multiple variations of the red pigments. Specifically in the case of "achiotl (light red)," technical analysis of the paint reveals multiple layers of the pigment although the layers of the pigment is not visible to the naked eye.
Labrador Retriever coat colour genetics the colour of the dark pigment, eumelanin, and is referred to as the B (brown) locus. The variation displayed by this locus is observed in many mammals, reflecting a so-called 'dilution', a lightening, of black eumelanin to a brown colour. Initial genetic research excluded a role for the melanocortin 1 receptor and the "Agouti" locus as being the cause of the black dilution trait in dogs. Instead, TYRP1 (tyrosine related protein 1) was found to be responsible. This enzyme is localised to melanosomes, the cellular organelles that produce and store pigments, and serves to catalyze oxidation of eumelanin precursors. In