Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Circle of a sphere satisfy The intersection of the spheres is the set of points satisfying both equations. Subtracting the equations gives In the singular case formula_7, the spheres are concentric. There are two possibilities: if formula_8, the spheres coincide, and the intersection is the entire sphere; if formula_9, the spheres are disjoint and the intersection is empty. When "a" is nonzero, the intersection lies in a vertical plane with this x-coordinate, which may intersect both of the spheres, be tangent to both spheres, or external to both spheres. The result follows from the previous proof for sphere-plane intersections. Circle of a sphere A