Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
What the World Needs Now Is Love assassination, and Martin Luther King, Jr., and soundbites of news coverage of each assassination. The ending of the song is a reprise of the introduction. "What the World Needs Now is Love/Abraham, Martin and John" rose to No. 8 on the "Billboard" Hot 100 in August 1971, and was Clay's only Top 40 hit. "What the World Needs Now is Love" has been used in many film soundtracks, notably "Bob & Carol & Ted & Alice" and "For the Love of Fred" (used as the film's closing theme song in both), "", "My Best Friend's Wedding", "", "The Boss Baby",