Schistosomiasis artesunate, or mefloquine. A Cochrane review found tentative evidence that when used alone, metrifonate was as effective as praziquantel. Another agent, mefloquine, which has previously been used to treat and prevent malaria, was recognised in 2008–2009 to be effective against "Schistosoma". Historically, antimony potassium tartrate remained the treatment of choice for schistosomiasis until the development of praziquantel in the 1980s. The disease is found in tropical countries in Africa, the Caribbean, eastern South America, Southeast Asia, and the Middle East. "S. mansoni" is found in parts of South America and the Caribbean, Africa, and the Middle East; "S. haematobium" in
International Association for the Treatment of Sexual Offenders as those individuals who (1) access child pornography due to impulse without any specific sexual interest in children; (2) access child pornography to satisfy sexual fantasies but do not commit contact sex offenses; (3) make and handout child pornography just for financial gain and benefit; and (4) use the Internet to facilitate contact sex offenses. Sexual offenders create many challenges for treatment providers probation officers, and even just regular people in their community. Sexual offenders create challenges because the treatment providers and probation officers have to decide what care is best and what limitations are necessary for that specific individual