Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Inscribed sphere Inscribed sphere In geometry, the inscribed sphere or insphere of a convex polyhedron is a sphere that is contained within the polyhedron and tangent to each of the polyhedron's faces. It is the largest sphere that is contained wholly within the polyhedron, and is dual to the dual polyhedron's circumsphere. The radius of the sphere inscribed in a polyhedron "P" is called the inradius of "P". All regular polyhedra have inscribed spheres, but most irregular polyhedra do not have all facets tangent to a common sphere, although it is still possible to define the largest contained sphere for such shapes.