Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Quasi-sphere hyperbolic plane, and its conjugate hyperbola, which is its counter-sphere. The "centre" of a quasi-sphere is a point that is equidistant from every point of the quasi-sphere – i.e., the quadratic form applied to the displacement vector (or radius vector) from the centre to a point of the quasi-sphere yields a constant, called the "radius squared", or equivalently, the point at which the pencil of lines normal to the tangent hyperplanes meet. If the quasi-sphere is a hyperplane, the centre is the point at infinity defined by this pencil. When , the displacement vector of the centre from the reference