Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Inscribed sphere For such cases, the notion of an insphere does not seem to have been properly defined and various interpretations of an "insphere" are to be found: Often these spheres coincide, leading to confusion as to exactly what properties define the insphere for polyhedra where they do not coincide. For example, the regular small stellated dodecahedron has a sphere tangent to all faces, while a larger sphere can still be fitted inside the polyhedron. Which is the insphere? Important authorities such as Coxeter or Cundy & Rollett are clear enough that the face-tangent sphere is the insphere. Again, such authorities agree