Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
What is a Masterpiece? confluence of memories and emotions forming a single idea", that it has "a power of recreating traditional forms so that they become expressive of an artist's own epoch and yet keep a relationship to the past". The highest masterpieces are said to be "illustrations of great themes." Clark also implicitly excluded the erotic from considerations of what constituted a masterpiece, based on his perspective that a necessary condition is the balance between sense and form (works that are too sensual are, therefore, unbalanced and not to be categorised at masterpiece level). What is a Masterpiece? What is a Masterpiece? is