Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Resinoid (perfumery) Resinoid (perfumery) Resinoids are extracts of resinous plant exudates (balsams, oleo gum resins, and natural oleoresins). Resinous plant exudates (balsams, oleo gum resins, and natural oleoresins) and animal secretions (ambergris, castoreum, musk, and civet) are extracted with solvents such as methanol, ethanol, toluene, or acetone. Yields range from 50 to 95 %. The products mainly consist of nonvolatile, resinous compounds. They are usually highly viscous and are sometimes diluted (e.g., with phthalates or benzyl benzoate) to improve their flow and processing properties. Resinoids are mainly used as perfume fixatives. The resinoids described above should be distinguished from prepared oleoresins (e.g.,