Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
People for the Ethical Treatment of Animals which it seeks to improve the treatment of, and also advocates for improvements for companion animals. In 2016, PETA Asia-Pacific shocked customers with a fake pop-up shop in Bangkok called The Leather Work, which seemed to specialize in "luxury" leather bags, shoes, and other clothing and accessories. Inside the items, though, were what appeared to be the gory flesh, sinews, beating hearts, and blood of animals slaughtered for such items. According to the "Asian Correspondent", the stunt caused shoppers to jump back and gasp in horror. PETA claims "to have found workers in crocodile farms 'sawing open reptile's necks while