Mefloquine during the study. Mefloquine was the first Public-Private Venture (PPV) between the US Department of Defense and a pharmaceutical company. WRAIR transferred all its phase I and phase II clinical trial data to Hoffman LaRoche and Smith Kline. FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. The drug was first approved and sold on a commercial basis in Switzerland in 1985. However, mefloquine was not approved by the FDA for prophylactic use until 1989. This approval was based primarily on compliance, while safety and tolerability were overlooked. Because of
Murder Ain't What it Used to Be Murder Ain't What it Used to Be Murder Ain't What it Used to Be is the seventh episode of the popular 1969 ITC British television series "Randall and Hopkirk (Deceased)" starring Mike Pratt, Kenneth Cope and Annette Andre. Directed by Jeremy Summers, the episode was first broadcast on 2 November 1969 on ITV. Crime boss Paul Kirstner flies over to Great Britain from New York City to attend to "business" in London. Behind most of the rackets in Chicago, he hires Jeff to protect his daughter from any of his enemies whilst in London. However, Kirstner is being haunted by