Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
What Is the What "we really hadn’t decided whether I was just helping Valentino write his own book, or if I was writing a book about him." Valentino points out that, "I thought I might want to write my own book, but I learned that I was not ready to do this. I was still taking classes in basic writing at Georgia Perimeter College." Dave Eggers discusses the difficulties in writing a book of this nature: "For a long while there, we continued doing interviews, and I gathered the material. But all along, I really didn’t know exactly what form it would finally take—whether