Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Circle of a sphere satisfy The intersection of the spheres is the set of points satisfying both equations. Subtracting the equations gives In the singular case formula_7, the spheres are concentric. There are two possibilities: if formula_8, the spheres coincide, and the intersection is the entire sphere; if formula_9, the spheres are disjoint and the intersection is empty. When "a" is nonzero, the intersection lies in a vertical plane with this x-coordinate, which may intersect both of the spheres, be tangent to both spheres, or external to both spheres. The result follows from the previous proof for sphere-plane intersections. Circle of a sphere A