Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sublunary sphere - the idea usually going hand in hand with geocentrism and the concept of a spherical Earth. Avicenna carried forward into the Middle Ages the Aristotelian idea of generation and corruption being limited to the sublunary sphere. Medieval scholastics like Thomas Aquinas - who charted the division between celestial and sublunary spheres in his work "Summa Theologica" - also drew on Cicero and Lucan for an awareness of the great frontier between Nature and Sky, sublunary and aetheric spheres. The result for medieval/Renaissance mentalities was a pervasive awareness of the existence, at the Moon, of what C.S. Lewis called 'this