Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere (novel) team returns to the habitat, Adams succeeds in opening and entering the sphere. Meanwhile, on the surface, a Pacific cyclone forces the supporting Naval ships to evacuate, trapping and isolating the scientists on the ocean floor for five days. Adams is found and returned to the DH-8 Habitat where he awakens with a terrible headache and little-to-no memory of how he opened the sphere or what occurred while he was inside. Immediately afterwards, the team is contacted by an intelligent, seemingly friendly alien entity that calls itself "Jerry". At first, Jerry communicates with the scientists using a numeric code transmitted