Malaria areas with high rates of malaria. Despite a need, no effective vaccine exists, although efforts to develop one are ongoing. The recommended treatment for malaria is a combination of antimalarial medications that includes an artemisinin. The second medication may be either mefloquine, lumefantrine, or sulfadoxine/pyrimethamine. Quinine along with doxycycline may be used if an artemisinin is not available. It is recommended that in areas where the disease is common, malaria is confirmed if possible before treatment is started due to concerns of increasing drug resistance. Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine-resistant "P. falciparum"
Alternative treatments used for the common cold children by 18%. Vitamin C also decreased the severity of colds. A systematic review by the Cochrane Collaboration, last updated in 2014, examines twenty-four randomized controlled trials studying various echinacea preparations for prevention and treatment of the common cold. Echinacea showed no benefit over placebo for prevention. Evidence for treatment was inconsistent. Reported side effects were rare. 2007 meta-analyses conclude that there is some evidence that echinacea may reduce either the duration or severity of the common cold, but results are not consistent. Use of echinacea preparations is not currently recommended. In the twelfth century, Moses Maimonides wrote, "Chicken soup