Salicylaldehyde be prepared from the corresponding phenol by the Duff reaction, or by treatment with paraformaldehyde in the presence of magnesium chloride and a base. Salicylaldehyde was identified as a characteristic aroma component of buckwheat. It is also one of the components of castoreum, the exudate from the castor sacs of the mature North American beaver ("Castor canadensis") and the European beaver ("Castor fiber"), used in perfumery. Furthermore, salicylaldehyde occurs in the larval defensive secretions of several leaf beetle species that belong the subtribe Chrysomelina. An example for a leaf beetle species that produces salicylaldehyde is the red poplar leaf beetle
Cantharidin treatment of cutaneous leishmaniasis in animal models. In addition to topical medical applications, cantharidin and its analogues may have activity against cancer cells. Laboratory studies with cultured tumor cells suggest that this activity may be the result of PP2A inhibition. Natural products preparations containing cantharidin appear frequently in popular media. Examples include: Cantharidin Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles. It is a burn agent or a poison in large doses, but preparations containing it were historically used as aphrodisiacs. In its natural form, cantharidin is secreted