Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Core sphere approximately 30% of the total product. Long before the Industrial Revolution, the core sphere was the entire economy. Families and communities provided for themselves by hunting and gathering. Then with industrialization came a market of competitive men working for wages and along with it what historians call the cult of domesticity. The core sphere became regarded not as part of the market sphere of the economy but more as emotional and altruistic behavior. Therefore, activities in the core sphere were not considered economic because they do not directly influence the market economy. As time has progressed towards the present, organizations