Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
A Girl Is a Half-formed Thing A Girl Is a Half-formed Thing A Girl Is a Half-formed Thing is the debut novel of Eimear McBride. This stream of consciousness novel explores an Irish girl's relationship with her disabled brother, religious mother, and her own troubled sexuality. Joshua Cohen described how McBride's experimental style "forgoes quotation marks and elides verbiage for sense, sound and sheer appearance on the page. For emphasis it occasionally wreaks havoc on capItalS and reverses letter order." McBride began writing her debut novel whilst working in a series of office temp jobs. It took nine years to find a publisher and was rejected