Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sphere The shortest distance along the surface between two distinct non-antipodal points on the sphere is the length of the smaller of the two arcs on the unique great circle that includes the two points. Equipped with this "great-circle distance", a great circle becomes the Riemannian circle. If a particular point on a sphere is (arbitrarily) designated as its "north pole", then the corresponding antipodal point is called the "south pole", and the equator is the great circle that is equidistant to them. Great circles through the two poles are called lines (or meridians) of longitude, and the line connecting the