Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
What Is This Thing Called Love? What Is This Thing Called Love? "What Is This Thing Called Love?" is a 1929 popular song written by Cole Porter, for the musical "Wake Up and Dream". It was first performed by Elsie Carlisle in March 1929. The song has become a popular jazz standard and one of Porter's most often played compositions. "Wake Up and Dream" ran for 263 shows in London. The show was also noticed in New York, and the critics praised Tilly Losch's performance of the song. The show was produced on Broadway in December 1929; in the American rendition, "What Is This Thing Called