Lycopene in fresh tomatoes. Processed tomato products such as pasteurized tomato juice, soup, sauce, and ketchup contain a higher concentration of bioavailable lycopene compared to raw tomatoes. Cooking and crushing tomatoes (as in the canning process) and serving in oil-rich dishes (such as spaghetti sauce or pizza) greatly increases assimilation from the digestive tract into the bloodstream. Lycopene is fat-soluble, so the oil is said to help absorption. Gac has high lycopene content derived mainly from its seed coats. Cara cara navel, and other citrus fruit, such as pink grapefruit, also contain lycopene. Some foods that do not appear red also
Lycopene pressure, interactions with drugs that affect blood pressure may occur. Lycopene may affect the immune system, the nervous system, sensitivity to sunlight, or drugs used for stomach ailments. Lycopenemia is an orange discoloration of the skin that is observed with high intakes of lycopene. The discoloration is expected to fade after discontinuing excessive lycopene intake. In a review of literature on lycopene and its potential role as a dietary antioxidant, the European Food Safety Authority concluded that evidence was insufficient for lycopene having antioxidant effects in humans, particularly in skin, heart function, or vision protection from ultraviolet light. Although lycopene