Antimalarial medication "Lariam". Lariam is fairly expensive at around 3 € per tablet (pricing of the year 2000). A dose of 15–25 mg/kg is recommended, depending on the prevalence of mefloquine resistance. The increased dosage is associated with a much greater level of intolerance, most noticeably in young children; with the drug inducing vomiting and esophagitis. It was not recommended for use during the first trimester, although considered safe during the second and third trimesters; nevertheless, in October 2011, the Centers for Disease Control and Prevention (CDC) changed its recommendation and approved use of Mefloquine for both prophylaxis and treatment of malaria
What Is and What Should Never Be What Is and What Should Never Be "What Is and What Should Never Be" is a song by English rock band Led Zeppelin. It was written by Jimmy Page and Robert Plant and was included as the second track on "Led Zeppelin II" (1969). "What is and What Should Never Be" was one of the first songs on which Page used his soon-to-become trademark Gibson Les Paul for recording. The production makes liberal use of stereo as the guitars pan back and forth between channels. Robert Plant's vocals were phased during the verses. Record producer Rick Rubin has remarked, "The