Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Dyson sphere Dyson sphere A Dyson sphere is a hypothetical megastructure that completely encompasses a star and captures a large percentage of its power output. The concept is a thought experiment that attempts to explain how a spacefaring civilization would meet its energy requirements once those requirements exceed what can be generated from the home planet's resources alone. Only a fraction of a star's energy emissions reach the surface of any orbiting planet. Building structures encircling a star would enable a civilization to harvest far more energy. The first contemporary description of the structure was by Olaf Stapledon in his science fiction