Mefloquine in "Pfmdr1" copy number. Mefloquine is contraindicated in those with a previous history of seizures or a recent history of psychiatric disorders. Severe side effects requiring hospitalization are rare. Compared to other malaria prophylaxis regimens, mefloqinone may produce more side effects in non-pregnant travelers. In pregnant travelers, it appears to pose minimal risk to the fetus. In 2013 the United States Food and Drug Administration added a boxed warning to the U.S. label of mefloquine regarding the potential for neuropsychiatric side effects that may persist even after discontinuing administration of the drug. Psychiatric effects include nightmares, visual and auditory hallucinations,
The Old Blue Mayor She Ain't What She Used to Be The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the twenty-ninth season of the animated television series "The Simpsons", and the 624th episode of the series overall. It aired in the United States on Fox on November 12, 2017. The track of the old Springfield Monorail (from "Marge vs. the Monorail") is converted into a "sky park". At the official opening, Mayor Quimby turns on the electricity which causes the monorail car to activate and destroy the boardwalk, running down Sebastian Cobb