Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
International Association for the Treatment of Sexual Offenders as those individuals who (1) access child pornography due to impulse without any specific sexual interest in children; (2) access child pornography to satisfy sexual fantasies but do not commit contact sex offenses; (3) make and handout child pornography just for financial gain and benefit; and (4) use the Internet to facilitate contact sex offenses. Sexual offenders create many challenges for treatment providers probation officers, and even just regular people in their community. Sexual offenders create challenges because the treatment providers and probation officers have to decide what care is best and what limitations are necessary for that specific individual