Drug injection taking drugs, injection is favoured by some people as the full effects of the drug are experienced very quickly, typically in five to ten seconds. It also bypasses first-pass metabolism in the liver, resulting in higher bioavailability and efficiency for many drugs (such as morphine or diacetylmorphine/heroin; roughly two-thirds of which is destroyed in the liver when consumed orally) than oral ingestion would. The effect is that the person gets a stronger (yet shorter-acting) effect from the same amount of the drug. Drug injection is therefore often related to substance dependence. In a recreational context, the shorter, more intense "high"
Drug Price Competition and Patent Term Restoration Act the Act allowed the life of patents covering a drug to be extended by a portion of the time the drug is under regulatory review by the FDA, ensuring innovator companies that regulatory review will not unduly consume patent life. The Act also requires the drug innovator to provide the FDA with the numbers of patents it believes cover its drug; the FDA does not evaluate whether the patents cover the drug or not, but it publicly lists those patents in the Orange Book, and these are the patents, the life of which gets extended if there are regulatory delays.