Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Alexander horned sphere where the need for distinction between the topological category of manifolds, and the categories of differentiable manifolds, and piecewise linear manifolds was noticed. Now consider Alexander's horned sphere as an embedding into the 3-sphere, considered as the one-point compactification of the 3-dimensional Euclidean space R. The closure of the non-simply connected domain is called the solid Alexander horned sphere. Although the solid horned sphere is not a manifold, R. H. Bing showed that its double (which is the 3-manifold obtained by gluing two copies of the horned sphere together along the corresponding points of their boundaries) is in fact the