Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sublunary sphere - the idea usually going hand in hand with geocentrism and the concept of a spherical Earth. Avicenna carried forward into the Middle Ages the Aristotelian idea of generation and corruption being limited to the sublunary sphere. Medieval scholastics like Thomas Aquinas - who charted the division between celestial and sublunary spheres in his work "Summa Theologica" - also drew on Cicero and Lucan for an awareness of the great frontier between Nature and Sky, sublunary and aetheric spheres. The result for medieval/Renaissance mentalities was a pervasive awareness of the existence, at the Moon, of what C.S. Lewis called 'this