Minium (pigment) 300 B.C. It was known in the Han Dynasty (200 BC-200 AD) under the name "cinnabar of lead" ("ch'ien tan"), The process of manufacturing it was described in a Chinese manuscript of the 5th century. Minium was widely used for Persian miniature painting and Indian miniature painting. Minium (pigment) Minium, also known as red lead, is a bright orange red pigment that was widely used in the Middle Ages for the decoration of manuscripts and for painting. It was made by roasting white lead pigment in the air; the white lead would gradually turn yellow, then into an orange lead
Retinal pigment epithelium degeneration and retinitis pigmentosa. RPE are also involved in diabetic retinopathy. Gardner syndrome is characterized by FAP (Familial Adenomatous Polyps), osseous and soft tissue tumors, retinal pigment epithelium hypertrophy and impacted teeth. Retinal pigment epithelium The pigmented layer of retina or retinal pigment epithelium (RPE) is the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells. The RPE was known in the 18th and 19th centuries as the pigmentum nigrum, referring to the observation that the RPE is dark (black in many animals,