Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Cybernetics: Or Control and Communication in the Animal and the Machine derived from Maltz's work. "Cybernetics" became a surprise bestseller and was widely read beyond the technical audience that Wiener had expected. In response he wrote "The Human Use of Human Beings" in which he further explored the social and psychological implications in a format more suited to the non-technical reader. In 1954, Marie Neurath produced a children's book "Machines which seem to Think" , which introduced the concepts of "Cybernetics", control systems and negative feedback in an accessible format. Cybernetics: Or Control and Communication in the Animal and the Machine Cybernetics: Or Control and Communication in the Animal and the