Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Science On a Sphere runs on Linux. SOS was invented by Alexander E. MacDonald, the former director of the National Oceanographic and Atmospheric Administration (NOAA) Earth System Research Laboratory in Boulder, CO, and OAR Deputy Assistant Administrator for the NOAA Research Laboratories and Cooperative Institutes. MacDonald devised the original idea for Science On a Sphere in 1995 as part of other data visualization work he oversaw in what was the former NOAA Forecast Systems Laboratory. A small but highly motivated and inventive team of NOAA staff led by chief designer David Himes wrote the SOS software and developed the SOS hardware and system architecture.