Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
International Association for the Treatment of Sexual Offenders and treatment targets (such as cognitive distortions). Responsivity issues are the parts that affect how much the client(s) benefit or fail to benefit from the treatment and care programs. This proves that the treatment of sexual offenders has to be specific and different than another offenders treatment. Treatment of sexual offenders is very complicated and it is crucial to take the proper guidelines for the treatment to not only be successful but also to be long-lasting. Youths between the ages of 12-18 who have been either officially charged with a sexual crime or have performed an act that could be