Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
This Is What You Came For among artists to 73). "This Is What You Came For" became Rihanna's 25th and Harris's fourth number one on the Hot Dance Club Songs Chart, where it became the first song since 2013's "Wake Me Up" to stay at number one for two weeks. As of October 2016, the single has sold 1.2 million copies in the United States. "This Is What You Came For" debuted at number one on the Scottish Singles Chart, and peaked at number one in Australia, Canada and Ireland. The song also reached the top 10 in Germany, Ireland, New Zealand, Switzerland, Belgium, Denmark, Finland,