Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
3-sphere homeomorphic to the one-point compactification of . In general, any topological space that is homeomorphic to the 3-sphere is called a topological 3-sphere. The homology groups of the 3-sphere are as follows: and are both infinite cyclic, while for all other indices . Any topological space with these homology groups is known as a homology 3-sphere. Initially Poincaré conjectured that all homology 3-spheres are homeomorphic to , but then he himself constructed a non-homeomorphic one, now known as the Poincaré homology sphere. Infinitely many homology spheres are now known to exist. For example, a Dehn filling with slope on any