Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
What Is a Nation? to the reasons based on race, geography, history and so on. They argue that Renan maintains his intellectual background but subtly, i.e. the arguments he explicitly used in "What is a Nation?" are not consistent with his thinking. The concept of "daily plebiscite" would be ambiguous. They argue that the definition is an opportunist idealization and it should be interpreted within the Franco-Prussian War and in the midst of the dispute concerning the Alsace-Lorraine region. What Is a Nation? "What is a Nation?" ("Qu'est-ce qu'une nation?") is an 1882 lecture by French historian Ernest Renan (1823–1892), known for the statements