Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Public sphere that are "parallel discursive arenas where members of subordinated social groups invent and circulate counterdiscourses to formulate oppositional interpretations of their identities, interests, and needs". Benhabib notes that in Habermas' idea of the public sphere, the distinction between public and private issues separates issues that normally affect women (issues of "reproduction, nurture and care for the young, the sick, and the elderly") into the private realm and out of the discussion in the public sphere. She argues that if the public sphere is to be open to any discussion that affects the population, there cannot be distinctions between "what is"