Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Castor and Pollux (Prado) into the Prado (catalogue number Catalogue Nr. E.28). The erroneous identification with Antinous generated high interest in the sculpture, with large numbers of copies being produced, largely made in Italy and Northern Europe and based on plaster casts rather than made in Spain and based on the original there. These inevitably stoked the interest by obscuring the fact that the Antinous head was in fact a restoration, instead smoothing the two into a meaningful whole (as did the casts on which they were based). Main site about copies of the Ildefonso (or Castor & Pollux) group : http://www.antinoos.info/copies1.htm Copies Castor