Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Exotic sphere Similar manifolds are called Brieskorn spheres. Given an (orientation-preserving) diffeomorphism , gluing the boundaries of two copies of the standard disk "D" together by "f" yields a manifold called a "twisted sphere" (with "twist" "f"). It is homotopy equivalent to the standard "n"-sphere because the gluing map is homotopic to the identity (being an orientation-preserving diffeomorphism, hence degree 1), but not in general diffeomorphic to the standard sphere. Setting formula_25 to be the group of twisted "n"-spheres (under connect sum), one obtains the exact sequence For , every exotic "n"-sphere is diffeomorphic to a twisted sphere, a result proven by