Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Celestial sphere spheres" was thought to carry the fixed stars. Eudoxus used 27 concentric spherical solids to answer Plato's challenge: "By the assumption of what uniform and orderly motions can the apparent motions of the planets be accounted for?" A celestial sphere can also refer to a physical model of the celestial sphere or celestial globe. Such globes map the constellations on the "outside" of a sphere, resulting in a mirror image of the constellations as seen from Earth. The oldest surviving example of such an artifact is the globe of the Farnese Atlas sculpture, a 2nd-century copy of an older (Hellenistic