Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Sphere sphere orthogonal to any two spheres of a pencil of spheres is orthogonal to all of them and its center lies in the radical plane of the pencil. Pairs of points on a sphere that lie on a straight line through the sphere's center are called antipodal points. A great circle is a circle on the sphere that has the same center and radius as the sphere and, consequently, divides it into two equal parts. The plane sections of a sphere are called "spheric sections". They are all circles and those that are not great circles are called "small circles".