Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sphere (2013 film) Sphere (2013 film) Sphere is a British animated short film created in 2013 by Aardman Animations for the University of Bristol and the Elizabeth Blackwell Institute. It was directed by Richard Webber. "Sphere " "involved asking members of the general public for their views on the technologies being developed in a project called SPHERE (Sensor Platform for HEalthcare in a Residential Environment), and what the outcomes might mean for them". As a result, "The creatures within the animation voiced opinions which reflected public reaction to SPHERE". "Sphere " was created in preparation for the launch of the Elizabeth Blackwell Institute.