Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
Cute Is What We Aim For to finish up high school and after that I was like, 'Wow, I miss playing music.' I was blessed enough to get that opportunity again." However, Cimato left the band once again in March 2008. It was announced that Dave Melillo would play bass until further notice. In 2008, Cute Is What We Aim For entered the studio to record with producer John Feldmann. "Rotation" debuted at #21 on the U.S. Billboard 200 albums chart selling around 22,000 copies. In 2010, it was announced that the band Cute Is What We Aim For lost all of its members except for