Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Inscribed sphere Inscribed sphere In geometry, the inscribed sphere or insphere of a convex polyhedron is a sphere that is contained within the polyhedron and tangent to each of the polyhedron's faces. It is the largest sphere that is contained wholly within the polyhedron, and is dual to the dual polyhedron's circumsphere. The radius of the sphere inscribed in a polyhedron "P" is called the inradius of "P". All regular polyhedra have inscribed spheres, but most irregular polyhedra do not have all facets tangent to a common sphere, although it is still possible to define the largest contained sphere for such shapes.