Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
Community Alliance for the Ethical Treatment of Youth Representatives, but was not acted upon in the Senate and did not become law. Community Alliance for the Ethical Treatment of Youth The Community Alliance For the Ethical Treatment of Youth (CAFETY) is an advocacy group for people enrolled in residential treatment programs for at-risk teenagers. The group's mission includes advocating for access to advocates, due process, alternatives to aversive behavioral interventions, and alternatives to restraints and seclusion for young people in treatment programs. They have also called for the routine reporting of abuse in residential treatment programs, as well as federal government oversight and regulation of residential treatment programs.