Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Private sphere of experiential knowledge and the world of the body – as against the (traditional) male preserves of public speech and theory. All the while, the public sphere of work, business, politics and ideas were increasingly opened up to female participation. Martin Heidegger argued that it is only in the private sphere that one can be one's authentic self, as opposed to the impersonal and identikit They of the public realm. Richard Sennett however opposed what he saw as the Romantic idealisation of the private realm of intimate relations, as opposed to the public sphere of action at a distance. Deleuze