Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere which is the center of the mathematical ball. These are also referred to as the radius and center of the sphere, respectively. The longest straight line through the ball, connecting two points of the sphere, passes through the center and its length is thus twice the radius; it is a diameter of both the sphere and its ball. While outside mathematics the terms "sphere" and "ball" are sometimes used interchangeably, in mathematics the above distinction is made between a "sphere", which is a two-dimensional closed surface, embedded in a three-dimensional Euclidean space, and a "ball", which is a three-dimensional shape