Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
This Is What You Came For among artists to 73). "This Is What You Came For" became Rihanna's 25th and Harris's fourth number one on the Hot Dance Club Songs Chart, where it became the first song since 2013's "Wake Me Up" to stay at number one for two weeks. As of October 2016, the single has sold 1.2 million copies in the United States. "This Is What You Came For" debuted at number one on the Scottish Singles Chart, and peaked at number one in Australia, Canada and Ireland. The song also reached the top 10 in Germany, Ireland, New Zealand, Switzerland, Belgium, Denmark, Finland,