Antimalarial medication multi-drug resistant "P. falciparum". It is a very potent blood schizonticide with a long half-life. It is thought to act by forming toxic heme complexes that damage parasitic food vacuoles. Mefloquine is effective in prophylaxis and for acute therapy. It is now used solely for the prevention of resistant strains of "P. falciparum" (usually combined with Artesunate) despite being effective against "P. vivax", "P. ovale" and "P. marlariae". Chloroquine/proguanil or sulfa drug-pyrimethamine combinations should be used in all other plasmodia infections. The major commercial manufacturer of mefloquine-based malaria treatment is Roche Pharmaceuticals, which markets the drug under the trade name
Things Ain't What They Used to Be Things Ain't What They Used to Be "Things Ain't What They Used to Be" is a 1942 jazz standard with music by Mercer Ellington and lyrics by Ted Persons. In 1941 there was a strike against the American Society of Composers, Authors and Publishers, of which Duke Ellington was a member. Because of the strike he could not air his songs on the radio. Instead, he used songs written by his son Mercer and pianist Billy Strayhorn. Strayhorn's compositions of this time include "Take the 'A' Train", "Chelsea Bridge" and "Day Dream". Mercer wrote "Things Ain't What They Used to