Esophageal pH monitoring developed a dependable external reference electrode. Using this technique to monitor esophageal acid exposure patients for periods up to 24 hours, DeMeester and Johnson were able to identify the most important parameters of esophageal acid exposure, and they developed a composite pH score to quantify gastroesophageal reflux. The initial 24-hour pH studies required hospitalization until the introduction of microcircuits in the 1980s that allowed portable esophageal pH monitoring in an outpatient setting. Gastroesophageal reflux disease (GERD) is a common disease in western countries. In the United States, 7% of the population experiences heartburn daily and 44% at least once a
Alkali Act 1863 Alkali Act 1863 Under the British Alkali Act 1863, an alkali inspector and four subinspectors were appointed to curb discharge into the air of muriatic acid gas (gaseous hydrochloric acid) from Leblanc alkali works. In 1874, under the Alkali Act 1874, the Inspector became the Chief Inspector. The first Chief Inspector was Dr Robert Angus Smith, he was statutorily responsible for the standards set and maintained by the Inspectorate, and reported directly to the Permanent Secretary of his department. For the first sixty years of its existence, the Inspectorate was solely concerned with the heavy chemicals industry, but from the