Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Unit sphere to a metric space, with respect to a chosen origin. However, topological considerations (interior, closure, border) need not apply in the same way (e.g., in ultrametric spaces, all of the three are simultaneously open and closed sets), and the unit sphere may even be empty in some metric spaces. If "V" is a linear space with a real quadratic form "F":"V" → R, then { p ∈ "V" : "F"(p) = 1 } may be called the unit sphere or unit quasi-sphere of "V". For example, the quadratic form formula_29, when set equal to one, produces the unit hyperbola which