Antimalarial medication "Lariam". Lariam is fairly expensive at around 3 € per tablet (pricing of the year 2000). A dose of 15–25 mg/kg is recommended, depending on the prevalence of mefloquine resistance. The increased dosage is associated with a much greater level of intolerance, most noticeably in young children; with the drug inducing vomiting and esophagitis. It was not recommended for use during the first trimester, although considered safe during the second and third trimesters; nevertheless, in October 2011, the Centers for Disease Control and Prevention (CDC) changed its recommendation and approved use of Mefloquine for both prophylaxis and treatment of malaria
The purpose of a system is what it does The purpose of a system is what it does The purpose of a system is what it does (POSIWID) is a systems thinking heuristic coined by Stafford Beer. Stafford Beer coined the term POSIWID and used it many times in public addresses. In his address to the University of Valladolid, Spain, in October 2001, he said "According to the cybernetician, the purpose of a system is what it does. This is a basic dictum. It stands for bald fact, which makes a better starting point in seeking understanding than the familiar attributions of good intention, prejudices about expectations, moral judgment,