Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
Things Ain't What They Used to Be Things Ain't What They Used to Be "Things Ain't What They Used to Be" is a 1942 jazz standard with music by Mercer Ellington and lyrics by Ted Persons. In 1941 there was a strike against the American Society of Composers, Authors and Publishers, of which Duke Ellington was a member. Because of the strike he could not air his songs on the radio. Instead, he used songs written by his son Mercer and pianist Billy Strayhorn. Strayhorn's compositions of this time include "Take the 'A' Train", "Chelsea Bridge" and "Day Dream". Mercer wrote "Things Ain't What They Used to