Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Celestial sphere Celestial sphere In astronomy and navigation, the celestial sphere is an abstract sphere that has an arbitrarily large radius and is concentric to Earth. All objects in the sky can be conceived as being projected upon the inner surface of the celestial sphere, which may be centered on Earth or the observer. If centered on the observer, half of the sphere would resemble a hemispherical screen over the observing location. The celestial sphere is a practical tool for spherical astronomy, allowing astronomers to specify the apparent positions of objects in the sky if their distances are unknown or irrelevant. In