Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Inversion in a sphere compactification of formula_3, by specifying that 0 should be sent to infinity and infinity should be sent to 0. Thus, spherical inversion can be thought of as a homeomorphism of formula_2. Inversion is self-inverse, and fixes the points lying on the sphere. The inverse of a line is a circle through the centre of the reference sphere, and vice versa. The inverse of a plane is a sphere through the centre of the reference sphere, and vice versa. Otherwise the inverse of a circle is a circle; the inverse of a sphere is a sphere. Inversion in a sphere is