Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Animal welfare and rights in Malaysia owning an animal indefinitely. The AWA also increases the penalty for cruelty from the AA's maximum of a RM200 fine and/or up to 6 months imprisonment, to a fine between RM20,000 and RM100,000 and/or up to 3 years in prison. In 2014 (before the passage of the AWA), Malaysia received a C out of possible grades A,B,C,D,E,F,G on World Animal Protection's Animal Protection Index. Penalties for cruelty towards animals have historically been very mild. According to SEE (2013), "These cases more or less sum up the history of animal cruelty prosecution in Malaysia." There were also an additional four animal