Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Sphere (novel) team returns to the habitat, Adams succeeds in opening and entering the sphere. Meanwhile, on the surface, a Pacific cyclone forces the supporting Naval ships to evacuate, trapping and isolating the scientists on the ocean floor for five days. Adams is found and returned to the DH-8 Habitat where he awakens with a terrible headache and little-to-no memory of how he opened the sphere or what occurred while he was inside. Immediately afterwards, the team is contacted by an intelligent, seemingly friendly alien entity that calls itself "Jerry". At first, Jerry communicates with the scientists using a numeric code transmitted