Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sphere the minor axis, an oblate spheroid. In three dimensions, the volume inside a sphere (that is, the volume of a ball, but classically referred to as the volume of a sphere) is where is the radius of the sphere. Archimedes first derived this formula, by showing that the volume inside a sphere is twice the volume between the sphere and the circumscribed cylinder of that sphere (having the height and diameter equal to the diameter of the sphere). This assertion can be obtained from Cavalieri's principle. This formula can also be derived using integral calculus, i.e. disk integration to sum