Esophageal pH monitoring developed a dependable external reference electrode. Using this technique to monitor esophageal acid exposure patients for periods up to 24 hours, DeMeester and Johnson were able to identify the most important parameters of esophageal acid exposure, and they developed a composite pH score to quantify gastroesophageal reflux. The initial 24-hour pH studies required hospitalization until the introduction of microcircuits in the 1980s that allowed portable esophageal pH monitoring in an outpatient setting. Gastroesophageal reflux disease (GERD) is a common disease in western countries. In the United States, 7% of the population experiences heartburn daily and 44% at least once a
Acid–base reaction reacts with an alkali salt (a metal hydroxide), the product is a metal salt and water. Acid–alkali reactions are also neutralization reactions. In general, acid–alkali reactions can be simplified to by omitting spectator ions. Acids are in general pure substances that contain hydrogen cations () or cause them to be produced in solutions. Hydrochloric acid () and sulfuric acid () are common examples. In water, these break apart into ions: The alkali breaks apart in water, yielding dissolved hydroxide ions: Acid–base reaction An acid–base reaction is a chemical reaction that occurs between an acid and a base, which can be