Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere (2013 film) Sphere (2013 film) Sphere is a British animated short film created in 2013 by Aardman Animations for the University of Bristol and the Elizabeth Blackwell Institute. It was directed by Richard Webber. "Sphere " "involved asking members of the general public for their views on the technologies being developed in a project called SPHERE (Sensor Platform for HEalthcare in a Residential Environment), and what the outcomes might mean for them". As a result, "The creatures within the animation voiced opinions which reflected public reaction to SPHERE". "Sphere " was created in preparation for the launch of the Elizabeth Blackwell Institute.