Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
What Is a Man Without a Moustache? Times" had also expressed opinions of a divided nature. He called the film "pleasant if inconsequential", offered an opinion that it contains "good-natured sensibility" and a "slightly fabulous tone" while still feeling like "magic realism, without the magic", and concluded his review by stating that "the pleasant pointless of it all is laced with a tantalizing tease of allegory suggested by the dialectical twins and the strain of mellow nationalism in the dialogue." Reviewing the film for "TV Guide", Maitland McDonagh awarded the film three stars out of four calling it "sardonic" and "absurdist". What Is a Man Without a