Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Pith and substance to one of them will deal with the issue. For example, if the provision in question has no relation to the regulatory scheme, the question of its validity may be quickly answered on that ground alone. The pith and substance doctrine as applied in the jurisprudence of the Judicial Committee of the Privy Council, effectively the British Imperial Court of Appeal, has been carried to other Commonwealth federations. It is used in the Indian Constitution. It was also used in Northern Ireland under the Government of Ireland Act 1920. The substance of the doctrine has been cast in statutory form