Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
People for the Ethical Treatment of Animals used for live transport and traditional religious slaughter. The organization has also used the PETA Lettuce Ladies in local demonstrations. PETA Asia-Pacific regularly demonstrates against KFC outlets to promote better treatment of chickens used by the company. PETA Asia-Pacific supports the PETA campaign "I'd Rather Go Naked Than Wear Fur," in which celebrities appear nude to express their opposition to wearing fur. The group also stages anti-fur events to publicize its opposition to fur. PETA Asia-Pacific has been involved in several undercover investigations of fur farms in China. The group regularly protests the use of animals in entertainment, including circuses.