Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sphere space with possible self-intersections but without creating any crease, in a process called sphere eversion. The basic elements of Euclidean plane geometry are points and lines. On the sphere, points are defined in the usual sense. The analogue of the "line" is the geodesic, which is a great circle; the defining characteristic of a great circle is that the plane containing all its points also passes through the center of the sphere. Measuring by arc length shows that the shortest path between two points lying on the sphere is the shorter segment of the great circle that includes the points.