Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Unit sphere surface of what is commonly called a "circle", while such a circle's interior and surface together are the two-dimensional ball. Similarly, a two-dimensional sphere is the surface of the Euclidean solid known colloquially as a "sphere", while the interior and surface together are the three-dimensional ball. A unit sphere is simply a sphere of radius one. The importance of the unit sphere is that any sphere can be transformed to a unit sphere by a combination of translation and scaling. In this way the properties of spheres in general can be reduced to the study of the unit sphere. In