Mefloquine during the study. Mefloquine was the first Public-Private Venture (PPV) between the US Department of Defense and a pharmaceutical company. WRAIR transferred all its phase I and phase II clinical trial data to Hoffman LaRoche and Smith Kline. FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. The drug was first approved and sold on a commercial basis in Switzerland in 1985. However, mefloquine was not approved by the FDA for prophylactic use until 1989. This approval was based primarily on compliance, while safety and tolerability were overlooked. Because of
This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For is the first release by Bring Me the Horizon, released on 25 September 2004, through Thirty Days of Night Records in Australia and on 30 January 2005, through Visible Noise records in the UK. "This Is What the Edge of Your Seat Was Made For" was released on 25 September 2004 in the US through Earache Records. The original pressing, on Thirty Days of Night Records, was a strict run of only 1,000 copies. Its title comes from