Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
What Is This Thing Called Love? (Alexander O'Neal song) What Is This Thing Called Love? (Alexander O'Neal song) "What Is This Thing Called Love?" is a song written by Jimmy Jam and Terry Lewis and recorded by American recording artist Alexander O'Neal. It is the second single from the singer's fourth solo album, "All True Man" (1991). The song's distinctive backing vocals were performed by Lisa Keith. Following the successful chart performances of the "All True Man" single "All True Man", "What Is This Thing Called Love?" was released as the album's second single. Alexander O'Neal's 19th hit single and it reached #53 in the UK Singles Chart. In