Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Circumscribed sphere Circumscribed sphere In geometry, a circumscribed sphere of a polyhedron is a sphere that contains the polyhedron and touches each of the polyhedron's vertices. The word circumsphere is sometimes used to mean the same thing. As in the case of two-dimensional circumscribed circles, the radius of a sphere circumscribed around a polyhedron "P" is called the circumradius of "P", and the center point of this sphere is called the circumcenter of "P". When it exists, a circumscribed sphere need not be the smallest sphere containing the polyhedron; for instance, the tetrahedron formed by a vertex of a cube and its