Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Riemann sphere that group is called SO(3). In this sense, this is by far the most symmetric metric on the sphere. (The group of all isometries, known as O(3), is also 3-dimensional, but unlike SO(3) is not a connected space.) Conversely, let "S" denote the sphere (as an abstract smooth or topological manifold). By the uniformization theorem there exists a unique complex structure on "S", up to conformal equivalence. It follows that any metric on "S" is conformally equivalent to the round metric. All such metrics determine the same conformal geometry. The round metric is therefore not intrinsic to the Riemann sphere,