Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sphere sphere orthogonal to any two spheres of a pencil of spheres is orthogonal to all of them and its center lies in the radical plane of the pencil. Pairs of points on a sphere that lie on a straight line through the sphere's center are called antipodal points. A great circle is a circle on the sphere that has the same center and radius as the sphere and, consequently, divides it into two equal parts. The plane sections of a sphere are called "spheric sections". They are all circles and those that are not great circles are called "small circles".