Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
N-sphere then is uniformly distributed within the unit -ball (i.e., by simply discarding two coordinates). Note that if is sufficiently large, most of the volume of the -ball will be contained in the region very close to its surface, so a point selected from that volume will also probably be close to the surface. This is one of the phenomena leading to the so-called curse of dimensionality that arises in some numerical and other applications. N-sphere In mathematics, the -sphere is the generalization of the ordinary sphere to spaces of arbitrary dimension. It is an -dimensional manifold that can be embedded