Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere of annihilation "sphere of annihilation" remains in place, but a character can move it through mental effort. Mordicai Knode of Tor.com called the item "the best minor artifact" in the game. Sphere of annihilation A sphere of annihilation is a fictional magic item in the "Dungeons & Dragons" fantasy role-playing game. The sphere of annihilation appeared in first edition "Advanced Dungeons & Dragons" in the original 1979 "Dungeon Master's Guide". It also appeared in second edition "Advanced Dungeons & Dragons" in the 2nd edition "Dungeon Master's Guide" (1989). The sphere of annihilation appeared in the third edition "Dungeon Master's Guide" (2000), classified