Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Oily fish seafloor, whereas oily fish are pelagic, living in the water column away from the bottom. Oily fish meat is a good source of vitamins A and D, and is rich in omega-3 fatty acids (white fish also contain these nutrients but at a much lower concentration). For this reason the consumption of oily fish rather than white fish can be more beneficial to humans, particularly concerning cardiovascular diseases; however, oily fish are known to carry higher levels of contaminants (such as mercury or dioxin) than whitefish. Among other benefits, studies suggest that the omega-3 fatty acids in oily fish may