Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For is the first release by Bring Me the Horizon, released on 25 September 2004, through Thirty Days of Night Records in Australia and on 30 January 2005, through Visible Noise records in the UK. "This Is What the Edge of Your Seat Was Made For" was released on 25 September 2004 in the US through Earache Records. The original pressing, on Thirty Days of Night Records, was a strict run of only 1,000 copies. Its title comes from