Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
N-sphere then is uniformly distributed within the unit -ball (i.e., by simply discarding two coordinates). Note that if is sufficiently large, most of the volume of the -ball will be contained in the region very close to its surface, so a point selected from that volume will also probably be close to the surface. This is one of the phenomena leading to the so-called curse of dimensionality that arises in some numerical and other applications. N-sphere In mathematics, the -sphere is the generalization of the ordinary sphere to spaces of arbitrary dimension. It is an -dimensional manifold that can be embedded