Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Inversion in a sphere a powerful transformation. One simple example is in map projection. The usual projection of the North or South Pole is inversion from the Earth to a plane. If instead of making a pole the centre, we chose a city, then Inversion could produce a map where all the shortest routes (great circles) for flying from that city would appear as straight lines, which would simplify the flight path, for passengers at least. Let the reference sphere be Σ, with centre O and radius r denoted by {O, r}. All inverses, in this paper, are in the sphere Σ. The results