Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Animal welfare and rights in France Animal welfare and rights in France Animal welfare and rights in France is about the treatment of and laws concerning non-human animals in France. France has moderate animal welfare protections by international standards. France passed its first animal protection law in 1850, though this law prohibited only public cruelty towards animals. In 1959 France issued a decree incriminating the mistreatment of domestic or captive animals. In 1976, France passed an animal welfare law which recognizes the sentience of domestic animals (making it one of the first countries to recognize animal sentience) and requires that alternatives to animal testing be used