Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
3-sphere of the three-sphere. Here we describe gluing a pair of three-balls and then the one-point compactification. A 3-sphere can be constructed topologically by "gluing" together the boundaries of a pair of 3-balls. The boundary of a 3-ball is a 2-sphere, and these two 2-spheres are to be identified. That is, imagine a pair of 3-balls of the same size, then superpose them so that their 2-spherical boundaries match, and let matching pairs of points on the pair of 2-spheres be identically equivalent to each other. In analogy with the case of the 2-sphere (see below), the gluing surface is called