Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Public sphere public sphere involves what is the basic theoretical structure of the public sphere, how information is deliberated in the public sphere, and what influence the public sphere has over society. What does it mean that something is "public"? Jürgen Habermas says, "We call events and occasions 'public' when they are open to all, in contrast to closed or exclusive affairs". This notion of the public becomes evident in terms such as public health, public education, public opinion or public ownership. They are opposed to the notions of private health, private education, private opinion, and private ownership. The notion of the