Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Circle of a sphere Circle of a sphere A circle of a sphere is a circle that lies on a sphere. Such a circle can be formed as the intersection of a sphere and a plane, or of two spheres. A circle on a sphere whose plane passes through the center of the sphere is called a great circle; otherwise it is a small circle. Circles of a sphere have radius less than or equal to the sphere radius, with equality when the circle is a great circle. In the geographic coordinate system on a globe, the parallels of latitude are such circles, with