Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
Cute Is What We Aim For to finish up high school and after that I was like, 'Wow, I miss playing music.' I was blessed enough to get that opportunity again." However, Cimato left the band once again in March 2008. It was announced that Dave Melillo would play bass until further notice. In 2008, Cute Is What We Aim For entered the studio to record with producer John Feldmann. "Rotation" debuted at #21 on the U.S. Billboard 200 albums chart selling around 22,000 copies. In 2010, it was announced that the band Cute Is What We Aim For lost all of its members except for