Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Circle of a sphere satisfy The intersection of the spheres is the set of points satisfying both equations. Subtracting the equations gives In the singular case formula_7, the spheres are concentric. There are two possibilities: if formula_8, the spheres coincide, and the intersection is the entire sphere; if formula_9, the spheres are disjoint and the intersection is empty. When "a" is nonzero, the intersection lies in a vertical plane with this x-coordinate, which may intersect both of the spheres, be tangent to both spheres, or external to both spheres. The result follows from the previous proof for sphere-plane intersections. Circle of a sphere A