Grandchildren of Queen Victoria and Prince Albert of Saxe-Coburg and Gotha of Wales, married Princess Alexandra of Denmark (1844–1925), later Queen Alexandra of the United Kingdom, on 10 March 1863. They had 3 sons (one of whom died within a day), 3 daughters, 7 grandsons (one stillborn) and 3 granddaughters. The Prince of Wales became King Edward VII and Emperor of India at the death of his mother Queen Victoria on 22 January 1901. Edward's and Alexandra's son King George V (reigned 1910–1936) was the father of Kings Edward VIII (reigned 1936) and George VI (1936–1952), and the grandfather of the present Queen Elizabeth II (acceded to the throne February 1952)
Victoria Eugenie of Battenberg prince was being circumcised, the doctors noted that he did not stop bleeding — the first sign that the infant heir had haemophilia. Victoria Eugenie was the obvious source of the condition, which was inherited by her eldest and youngest sons. Contrary to the response of Emperor Nicholas II of Russia, whose son and heir by another granddaughter of Queen Victoria was similarly afflicted, Alfonso is alleged never to have forgiven Victoria Eugenie nor to have come to terms with what had happened. In all, King Alfonso XIII and Queen Victoria Eugenie had seven children, five sons and two daughters.