PH a pH of 7.3. This is clearly wrong as an acid solution should have a pH of less than 7. Treating the system as a mixture of hydrochloric acid and the amphoteric substance water, a pH of 6.89 results. A weak acid or the conjugate acid of a weak base can be treated using the same formalism. First, an acid dissociation constant is defined as follows. Electrical charges are omitted from subsequent equations for the sake of generality and its value is assumed to have been determined by experiment. This being so, there are three unknown concentrations, [HA], [H] and
Uric acid 1882, the Ukrainian chemist Ivan Horbaczewski first synthesized uric acid by melting urea with glycine. Uric acid displays lactam–lactim tautomerism (also often described as keto–enol tautomerism). Although the lactim form is expected to possess some degree of aromaticity uric acid crystallizes in the lactam form, with computational chemistry also indicating that tautomer to be the most stable. Uric acid is a diprotic acid with p"K" = 5.4 and p"K" = 10.3, thus at physiological pH it predominately exists as the monoionic urate ion. In general, the water solubility of uric acid and its alkali metal and alkaline earth salts is