Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Opium (perfume) Opium (perfume) Opium is an Oriental-spicy perfume created for fashion brand Yves Saint Laurent (YSL) by perfumer Jean Amic and Jean-Louis Sieuzac of Roure, first marketed in 1977. Its top notes are a mixture of fruit and spices, with mandarin orange, plum, clove, coriander and pepper, as well as bay leaf. Its floral middle notes consist predominantly jasmine, rose and Lily of the Valley, in addition to carnation, cinnamon, peach and orris root. It is underlined by the sweet woody base note containing sandalwood, cedarwood, myrrh, opopanax, labdanum, benzoin and castoreum, in addition to amber, incense, musk, patchouli, tolu and