Antimalarial medication multi-drug resistant "P. falciparum". It is a very potent blood schizonticide with a long half-life. It is thought to act by forming toxic heme complexes that damage parasitic food vacuoles. Mefloquine is effective in prophylaxis and for acute therapy. It is now used solely for the prevention of resistant strains of "P. falciparum" (usually combined with Artesunate) despite being effective against "P. vivax", "P. ovale" and "P. marlariae". Chloroquine/proguanil or sulfa drug-pyrimethamine combinations should be used in all other plasmodia infections. The major commercial manufacturer of mefloquine-based malaria treatment is Roche Pharmaceuticals, which markets the drug under the trade name
What Bird is That? author Nick Earls' 1999 young adult novel "48 Shades of Brown". The 48 shades refers to the number of distinct browns used by Cayley to describe bird plumage colours. What Bird is That? What Bird is That? A Guide to the Birds of Australia is a book first published in 1931 by Angus & Robertson in Sydney. Authored and illustrated by Neville William Cayley, it was Australia’s first fully illustrated national field guide to birds, a function it served alone for nearly 40 years. In 1960 it was rated the all-time best seller in Australian natural history. "What Bird Is