Mefloquine is not recommended for severe malaria infections, particularly infections from "P. falciparum", which should be treated with intravenous antimalarials. Mefloquine does not eliminate parasites in the liver phase of the disease, and people with "P. vivax" malaria should be treated with a second drug that is effective for the liver phase, such as primaquine. Mefloquine is widely used for the treatment of malaria in pregnancy. Limited data suggests that it is safe for this purpose. Resistance to mefloquine is now common around the west border in Cambodia and other parts of Southeast Asia. The mechanism of resistance is by increase
Things Ain't What They Used to Be Be", "Blue Serge" and "Moon Mist". Jazz musician and historian Chris Tyle argues that most likely Mercer Ellington came up with the melody and his father then arranged the song for the band. The song is most often played as an instrumental. Lyrics were written by Ted Persons. Johnny Hodges played it first, in Hollywood on July 3, 1941. Duke Ellington played it for the film "Cabin in the Sky" (1943). Things Ain't What They Used to Be "Things Ain't What They Used to Be" is a 1942 jazz standard with music by Mercer Ellington and lyrics by Ted Persons.