Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Public sphere pedagogy opinion through critical rational discourse. Habermas argued that these discussions served to fill the gap between the state and the people by creating what he called a "civil society". Further, Habermas argued that a functioning public sphere was critical to maintaining a healthy democratic order and deliberative democracy. This traditional notion of a face-to-face public sphere has evolved with the invention of online technologies. The public sphere no longer requires a physical setting, but can manifest in cyberspace. The coffee house discussions idealized by Habermas have expanded to blogs, discussion forums, and online videos. Henry Giroux in particular discusses the