Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Circumscribed sphere Circumscribed sphere In geometry, a circumscribed sphere of a polyhedron is a sphere that contains the polyhedron and touches each of the polyhedron's vertices. The word circumsphere is sometimes used to mean the same thing. As in the case of two-dimensional circumscribed circles, the radius of a sphere circumscribed around a polyhedron "P" is called the circumradius of "P", and the center point of this sphere is called the circumcenter of "P". When it exists, a circumscribed sphere need not be the smallest sphere containing the polyhedron; for instance, the tetrahedron formed by a vertex of a cube and its