Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sphere a ball is called the specific surface area and can be expressed from the above stated equations as where is the density (the ratio of mass to volume). A sphere is uniquely determined by four points that are not coplanar. More generally, a sphere is uniquely determined by four conditions such as passing through a point, being tangent to a plane, etc. This property is analogous to the property that three non-collinear points determine a unique circle in a plane. Consequently, a sphere is uniquely determined by (that is, passes through) a circle and a point not in the plane