Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
What Is This Thing Called Love? (Alexander O'Neal song) What Is This Thing Called Love? (Alexander O'Neal song) "What Is This Thing Called Love?" is a song written by Jimmy Jam and Terry Lewis and recorded by American recording artist Alexander O'Neal. It is the second single from the singer's fourth solo album, "All True Man" (1991). The song's distinctive backing vocals were performed by Lisa Keith. Following the successful chart performances of the "All True Man" single "All True Man", "What Is This Thing Called Love?" was released as the album's second single. Alexander O'Neal's 19th hit single and it reached #53 in the UK Singles Chart. In