Schistosomiasis artesunate, or mefloquine. A Cochrane review found tentative evidence that when used alone, metrifonate was as effective as praziquantel. Another agent, mefloquine, which has previously been used to treat and prevent malaria, was recognised in 2008–2009 to be effective against "Schistosoma". Historically, antimony potassium tartrate remained the treatment of choice for schistosomiasis until the development of praziquantel in the 1980s. The disease is found in tropical countries in Africa, the Caribbean, eastern South America, Southeast Asia, and the Middle East. "S. mansoni" is found in parts of South America and the Caribbean, Africa, and the Middle East; "S. haematobium" in
Things Ain't What They Used to Be Things Ain't What They Used to Be "Things Ain't What They Used to Be" is a 1942 jazz standard with music by Mercer Ellington and lyrics by Ted Persons. In 1941 there was a strike against the American Society of Composers, Authors and Publishers, of which Duke Ellington was a member. Because of the strike he could not air his songs on the radio. Instead, he used songs written by his son Mercer and pianist Billy Strayhorn. Strayhorn's compositions of this time include "Take the 'A' Train", "Chelsea Bridge" and "Day Dream". Mercer wrote "Things Ain't What They Used to