Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
The Treatment Trap The Treatment Trap The Treatment Trap - How the Overuse of Medical Care is Wrecking your Health and what you can do to Prevent it is a 2010 book by Rosemary Gibson and Janardan Prasad Singh about unnecessary health care. AARP described the book as an exploration of "the reasons why many physicians are overly cautious, incompetent, or under great pressure to produce revenues in a health care system that seems to encourage these practices". A magazine review said that the message of the book was that "When it comes to health care, more is not always better." A reviewer