Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
What is a Masterpiece? confluence of memories and emotions forming a single idea", that it has "a power of recreating traditional forms so that they become expressive of an artist's own epoch and yet keep a relationship to the past". The highest masterpieces are said to be "illustrations of great themes." Clark also implicitly excluded the erotic from considerations of what constituted a masterpiece, based on his perspective that a necessary condition is the balance between sense and form (works that are too sensual are, therefore, unbalanced and not to be categorised at masterpiece level). What is a Masterpiece? What is a Masterpiece? is