Antimalarial medication multi-drug resistant "P. falciparum". It is a very potent blood schizonticide with a long half-life. It is thought to act by forming toxic heme complexes that damage parasitic food vacuoles. Mefloquine is effective in prophylaxis and for acute therapy. It is now used solely for the prevention of resistant strains of "P. falciparum" (usually combined with Artesunate) despite being effective against "P. vivax", "P. ovale" and "P. marlariae". Chloroquine/proguanil or sulfa drug-pyrimethamine combinations should be used in all other plasmodia infections. The major commercial manufacturer of mefloquine-based malaria treatment is Roche Pharmaceuticals, which markets the drug under the trade name
This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For is the first release by Bring Me the Horizon, released on 25 September 2004, through Thirty Days of Night Records in Australia and on 30 January 2005, through Visible Noise records in the UK. "This Is What the Edge of Your Seat Was Made For" was released on 25 September 2004 in the US through Earache Records. The original pressing, on Thirty Days of Night Records, was a strict run of only 1,000 copies. Its title comes from