Mefloquine is not recommended for severe malaria infections, particularly infections from "P. falciparum", which should be treated with intravenous antimalarials. Mefloquine does not eliminate parasites in the liver phase of the disease, and people with "P. vivax" malaria should be treated with a second drug that is effective for the liver phase, such as primaquine. Mefloquine is widely used for the treatment of malaria in pregnancy. Limited data suggests that it is safe for this purpose. Resistance to mefloquine is now common around the west border in Cambodia and other parts of Southeast Asia. The mechanism of resistance is by increase
International Association for the Treatment of Sexual Offenders (every single person's treatment and care is going to be different to what best fits that specific person). Every sex offender is different which is why their care and limits need to be properly customized for that individual in order to protect the people of the community and also to successfully prevent them from reoffending. The management of risk is an important part of treatment, but if there is only a limited focus on risk then it can lead to excessively confrontational therapeutic encounters, no close relationship between the offenders and clinicians (this can potentially make treatment unsuccessful because there