PH the Hammett acidity function, "H", has been developed in connection with superacids. The concept of "unified pH scale" has been developed on the basis of the absolute chemical potential of the proton. This model uses the Lewis acid–base definition. This scale applies to liquids, gases and even solids. In 2010, a new "unified absolute pH scale" has been proposed that would allow various pH ranges across different solutions to use a common proton reference standard. Pure water is neutral. When an acid is dissolved in water, the pH will be less than 7 (25 °C). When a base, or alkali,
Uric acid 1882, the Ukrainian chemist Ivan Horbaczewski first synthesized uric acid by melting urea with glycine. Uric acid displays lactam–lactim tautomerism (also often described as keto–enol tautomerism). Although the lactim form is expected to possess some degree of aromaticity uric acid crystallizes in the lactam form, with computational chemistry also indicating that tautomer to be the most stable. Uric acid is a diprotic acid with p"K" = 5.4 and p"K" = 10.3, thus at physiological pH it predominately exists as the monoionic urate ion. In general, the water solubility of uric acid and its alkali metal and alkaline earth salts is