Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Half a Life (memoir) could in no way have avoided the accident, the book details his attempts, over half his life, to come to terms with his feelings of responsibility. "Half a Life" was enthusiastically received by critics here and abroad. Writing in "The Guardian", writer and critic Robert McCrum called the book "a masterpiece...'Half my life ago, I killed a girl'. You'll rarely get a better first line. What follows—Strauss's precise, honest and rigorous account of a fateful road accident and its harrowing aftermath—fulfills every hope aroused in the casual reader. What starts as an 18-year-old's carefree outing in his father's car leads