Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
3-sphere its maximal size when the hyperplane cuts right through the "equator" of the 3-sphere. Then the 2-sphere shrinks again down to a single point as the 3-sphere leaves the hyperplane. A 3-sphere is a compact, connected, 3-dimensional manifold without boundary. It is also simply connected. What this means, in the broad sense, is that any loop, or circular path, on the 3-sphere can be continuously shrunk to a point without leaving the 3-sphere. The Poincaré conjecture, proved in 2003 by Grigori Perelman, provides that the 3-sphere is the only three-dimensional manifold (up to homeomorphism) with these properties. The 3-sphere is