Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For This Is What the Edge of Your Seat Was Made For is the first release by Bring Me the Horizon, released on 25 September 2004, through Thirty Days of Night Records in Australia and on 30 January 2005, through Visible Noise records in the UK. "This Is What the Edge of Your Seat Was Made For" was released on 25 September 2004 in the US through Earache Records. The original pressing, on Thirty Days of Night Records, was a strict run of only 1,000 copies. Its title comes from