Mefloquine is not recommended for severe malaria infections, particularly infections from "P. falciparum", which should be treated with intravenous antimalarials. Mefloquine does not eliminate parasites in the liver phase of the disease, and people with "P. vivax" malaria should be treated with a second drug that is effective for the liver phase, such as primaquine. Mefloquine is widely used for the treatment of malaria in pregnancy. Limited data suggests that it is safe for this purpose. Resistance to mefloquine is now common around the west border in Cambodia and other parts of Southeast Asia. The mechanism of resistance is by increase
This Is What You Came For among artists to 73). "This Is What You Came For" became Rihanna's 25th and Harris's fourth number one on the Hot Dance Club Songs Chart, where it became the first song since 2013's "Wake Me Up" to stay at number one for two weeks. As of October 2016, the single has sold 1.2 million copies in the United States. "This Is What You Came For" debuted at number one on the Scottish Singles Chart, and peaked at number one in Australia, Canada and Ireland. The song also reached the top 10 in Germany, Ireland, New Zealand, Switzerland, Belgium, Denmark, Finland,