PH of neutrality is not exactly 7 (25 °C), although this is a good approximation in most cases. Neutrality is defined as the condition where [H] = [OH] (or the activities are equal). Since self-ionization of water holds the product of these concentration [H]×[OH] = K, it can be seen that at neutrality [H] = [OH] = , or pH = pK/2. pK is approximately 14 but depends on ionic strength and temperature, and so the pH of neutrality does also. Pure water and a solution of NaCl in pure water are both neutral, since dissociation of water produces equal numbers
Acid dissociation constant the added complication that the neutral molecule is subject to an internal acid–base equilibrium in which the basic amino group attracts and binds the proton from the acidic carboxyl group, forming a zwitterion. At pH less than about 5 both the carboxylate group and the amino group are protonated. As pH increases the acid dissociates according to At high pH a second dissociation may take place. Thus the zwitterion, , is amphoteric because it may either be protonated or deprotonated. The equilibrium constant "K" for a base is usually defined as the "association" constant for protonation of the base, B,