Antimalarial medication "Lariam". Lariam is fairly expensive at around 3 € per tablet (pricing of the year 2000). A dose of 15–25 mg/kg is recommended, depending on the prevalence of mefloquine resistance. The increased dosage is associated with a much greater level of intolerance, most noticeably in young children; with the drug inducing vomiting and esophagitis. It was not recommended for use during the first trimester, although considered safe during the second and third trimesters; nevertheless, in October 2011, the Centers for Disease Control and Prevention (CDC) changed its recommendation and approved use of Mefloquine for both prophylaxis and treatment of malaria
The Old Blue Mayor She Ain't What She Used to Be The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the twenty-ninth season of the animated television series "The Simpsons", and the 624th episode of the series overall. It aired in the United States on Fox on November 12, 2017. The track of the old Springfield Monorail (from "Marge vs. the Monorail") is converted into a "sky park". At the official opening, Mayor Quimby turns on the electricity which causes the monorail car to activate and destroy the boardwalk, running down Sebastian Cobb