Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Kline sphere characterization Kline sphere characterization In mathematics, a Kline sphere characterization, named after John Robert Kline, is a topological characterization of a two-dimensional sphere in terms of what sort of subset separates it. Its proof was one of the first notable accomplishments of R. H. Bing; Bing gave an alternate proof using brick partitioning in his paper "Complementary domains of continuous curves" A simple closed curve in a two-dimensional sphere (for instance, its equator) separates the sphere into two pieces upon removal. If one removes a pair of points from a sphere, however, the remainder is connected. Kline's sphere characterization states that