Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
What is a Masterpiece? What is a Masterpiece? What is a Masterpiece? is a 1979 non-fiction book by British historian Kenneth Clark. It is a transcribed version of the Walter Neurath memorial lectures given by Clark. The work, initially released on 1 January 1979, received a Thames & Hudson republication on 1 May 1992. Kenneth Clark had already achieved fame with a series of popular books while also serving as, from 1969 on, the writer, producer and presenter of the BBC programme, "Civilisation", a pioneering television documentary series. The prestigious series earned a Peabody Award as well as general commercial success. In the work,