Mefloquine is not recommended for severe malaria infections, particularly infections from "P. falciparum", which should be treated with intravenous antimalarials. Mefloquine does not eliminate parasites in the liver phase of the disease, and people with "P. vivax" malaria should be treated with a second drug that is effective for the liver phase, such as primaquine. Mefloquine is widely used for the treatment of malaria in pregnancy. Limited data suggests that it is safe for this purpose. Resistance to mefloquine is now common around the west border in Cambodia and other parts of Southeast Asia. The mechanism of resistance is by increase
The Old Blue Mayor She Ain't What She Used to Be The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the twenty-ninth season of the animated television series "The Simpsons", and the 624th episode of the series overall. It aired in the United States on Fox on November 12, 2017. The track of the old Springfield Monorail (from "Marge vs. the Monorail") is converted into a "sky park". At the official opening, Mayor Quimby turns on the electricity which causes the monorail car to activate and destroy the boardwalk, running down Sebastian Cobb