Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Unit sphere to a metric space, with respect to a chosen origin. However, topological considerations (interior, closure, border) need not apply in the same way (e.g., in ultrametric spaces, all of the three are simultaneously open and closed sets), and the unit sphere may even be empty in some metric spaces. If "V" is a linear space with a real quadratic form "F":"V" → R, then { p ∈ "V" : "F"(p) = 1 } may be called the unit sphere or unit quasi-sphere of "V". For example, the quadratic form formula_29, when set equal to one, produces the unit hyperbola which