Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Private sphere of experiential knowledge and the world of the body – as against the (traditional) male preserves of public speech and theory. All the while, the public sphere of work, business, politics and ideas were increasingly opened up to female participation. Martin Heidegger argued that it is only in the private sphere that one can be one's authentic self, as opposed to the impersonal and identikit They of the public realm. Richard Sennett however opposed what he saw as the Romantic idealisation of the private realm of intimate relations, as opposed to the public sphere of action at a distance. Deleuze