Potamon fluviatile and covers parts of many countries with a Mediterranean coastline. It is found in mainland Italy and on the Balkan Peninsula from Dalmatia to the Axios River in Greece. It is also found on a number of islands, including Sicily, Malta and Gozo, the Ionian Islands, Aegean Islands, Sporades and Andros in the Cyclades. Although the species as a whole is widespread, it is declining in numbers, and these insular populations are particularly vulnerable. "Potamon fluviatile" is widely distributed in much of mainland Italy, especially in the provinces of Trento, Lombardy, Veneto, Liguria, Tuscany, Umbria, Lazio, Campania, Apulia, and Calabria,
Potamon fluviatile the larval stages inside the egg. "Potamon fluviatile" is edible, as indicated by its alternative specific epithet "edulis", and was known to the ancient Greeks; it is probably this species which they depicted on medals found at Agrigento, Sicily. More recently, the species was depicted on the 5¢ coin in the last series of Maltese coins before the introduction of the Euro there in 2007. "Potamon fluviatile" has a generalist diet, feeding on vegetable debris, scraping algae from surfaces, or preying on frogs, tadpoles, and various invertebrates, such as insect larvae, snails or worms. No predator seems to specialise on