Mefloquine during the study. Mefloquine was the first Public-Private Venture (PPV) between the US Department of Defense and a pharmaceutical company. WRAIR transferred all its phase I and phase II clinical trial data to Hoffman LaRoche and Smith Kline. FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. The drug was first approved and sold on a commercial basis in Switzerland in 1985. However, mefloquine was not approved by the FDA for prophylactic use until 1989. This approval was based primarily on compliance, while safety and tolerability were overlooked. Because of
Hyperbaric treatment schedules has shown success over the years. IWR is not without risk and should be undertaken with certain precautions. IWR would only be suitable for an organised and disciplined group of divers with suitable equipment and practical training in the procedure. Treatment of decompression sickness, arterial gas embolism, and other medical applications. The type of chamber which can be used depends on the maximum pressure required for the schedule, and what gases are used for treatment. Most treatment protocols for diving injuries require an attendant in the chamber, and a medical lock to transfer medical supplies into the chamber while under