PH of neutrality is not exactly 7 (25 °C), although this is a good approximation in most cases. Neutrality is defined as the condition where [H] = [OH] (or the activities are equal). Since self-ionization of water holds the product of these concentration [H]×[OH] = K, it can be seen that at neutrality [H] = [OH] = , or pH = pK/2. pK is approximately 14 but depends on ionic strength and temperature, and so the pH of neutrality does also. Pure water and a solution of NaCl in pure water are both neutral, since dissociation of water produces equal numbers
Uric acid 1882, the Ukrainian chemist Ivan Horbaczewski first synthesized uric acid by melting urea with glycine. Uric acid displays lactam–lactim tautomerism (also often described as keto–enol tautomerism). Although the lactim form is expected to possess some degree of aromaticity uric acid crystallizes in the lactam form, with computational chemistry also indicating that tautomer to be the most stable. Uric acid is a diprotic acid with p"K" = 5.4 and p"K" = 10.3, thus at physiological pH it predominately exists as the monoionic urate ion. In general, the water solubility of uric acid and its alkali metal and alkaline earth salts is