Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Inversion in a sphere compactification of formula_3, by specifying that 0 should be sent to infinity and infinity should be sent to 0. Thus, spherical inversion can be thought of as a homeomorphism of formula_2. Inversion is self-inverse, and fixes the points lying on the sphere. The inverse of a line is a circle through the centre of the reference sphere, and vice versa. The inverse of a plane is a sphere through the centre of the reference sphere, and vice versa. Otherwise the inverse of a circle is a circle; the inverse of a sphere is a sphere. Inversion in a sphere is