Mefloquine in "Pfmdr1" copy number. Mefloquine is contraindicated in those with a previous history of seizures or a recent history of psychiatric disorders. Severe side effects requiring hospitalization are rare. Compared to other malaria prophylaxis regimens, mefloqinone may produce more side effects in non-pregnant travelers. In pregnant travelers, it appears to pose minimal risk to the fetus. In 2013 the United States Food and Drug Administration added a boxed warning to the U.S. label of mefloquine regarding the potential for neuropsychiatric side effects that may persist even after discontinuing administration of the drug. Psychiatric effects include nightmares, visual and auditory hallucinations,
Things Ain't What They Used to Be Be", "Blue Serge" and "Moon Mist". Jazz musician and historian Chris Tyle argues that most likely Mercer Ellington came up with the melody and his father then arranged the song for the band. The song is most often played as an instrumental. Lyrics were written by Ted Persons. Johnny Hodges played it first, in Hollywood on July 3, 1941. Duke Ellington played it for the film "Cabin in the Sky" (1943). Things Ain't What They Used to Be "Things Ain't What They Used to Be" is a 1942 jazz standard with music by Mercer Ellington and lyrics by Ted Persons.