Mefloquine one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer. According to some research, the (+)-enantiomer is more effective in treating malaria, and the (–)-enantiomer specifically binds to adenosine receptors in the central nervous system, which may explain some of its psychotropic effects. Mefloquine was formulated at Walter Reed Army Institute of Research (WRAIR) in the 1970s shortly after the end of the Vietnam war. Mefloquine was number 142,490 of a total of 250,000 antimalarial compounds screened
People for the Ethical Treatment of Animals used for live transport and traditional religious slaughter. The organization has also used the PETA Lettuce Ladies in local demonstrations. PETA Asia-Pacific regularly demonstrates against KFC outlets to promote better treatment of chickens used by the company. PETA Asia-Pacific supports the PETA campaign "I'd Rather Go Naked Than Wear Fur," in which celebrities appear nude to express their opposition to wearing fur. The group also stages anti-fur events to publicize its opposition to fur. PETA Asia-Pacific has been involved in several undercover investigations of fur farms in China. The group regularly protests the use of animals in entertainment, including circuses.