Sabena followed on 1 May 1929 via Antwerp, Düsseldorf, and Essen. When Sabena was created, the airline was partly funded by Belgians in the Belgian Congo colony who lost their air service, an experimental passenger and cargo company (LARA) between Léopoldville, Lisala, and Stanleyville a year earlier and who expected the new Belgian national airline to fill this gap. On 12 February 1925, Sabena pioneered a long haul across Africa to Leopoldville, capital of the Belgian Congo. Throughout its history, Sabena had a long tradition of service to African destinations and for a long time these were the only profitable routes
Sabena Douglas DC-7C was introduced for long-haul routes but this plane would begin to be supplanted after only three years by the jet age. It remained in service on the transatlantic route until 1962. On 3 June 1954, a Soviet Air Force Mikoyan-Gurevich MiG-15 (NATO reporting name "Fagot") attacked a Sabena-operated Douglas DC-3 on a cargo flight from the United Kingdom to Yugoslavia, killing the radio operator and wounding both the captain and engineer. Co-pilot Douglas Wilson managed to land in Austria but the plane suffered significant damage. For the 1958 world exposition in Brussels, Sabena leased two Lockheed Super Constellations