Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere Two spheres intersect at the same angle at all points of their circle of intersection. They intersect at right angles (are orthogonal) if and only if the squares of the distance between their centers is equal to the sum of the squares of their radii. If and are the equations of two distinct spheres then is also the equation of a sphere for arbitrary values of the parameters and . The set of all spheres satisfying this equation is called a pencil of spheres determined by the original two spheres. In this definition a sphere is allowed to be a