Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Cybernetics: Or Control and Communication in the Animal and the Machine Cybernetics: Or Control and Communication in the Animal and the Machine Cybernetics: Or Control and Communication in the Animal and the Machine is a book written by Norbert Wiener and published in 1948. It is the first public usage of the term "cybernetics" to refer to self-regulating mechanisms. The book laid the theoretical foundation for servomechanisms (whether electrical, mechanical or hydraulic), automatic navigation, analog computing, artificial intelligence, neuroscience, and reliable communications. A second edition with minor changes and two additional chapters was published in 1961. The book aroused a considerable amount of public discussion and comment at the time of