Labrador Retriever coat colour genetics fur colour but those with black skin can potentially produce a Dudley. Dudleys breed true for both fur and skin. The ability of the E locus to override the coat colour directed by the B locus is a classical example of epistasis, where multiple genetic loci affect the same observed trait. The E locus also determines whether the phenotype due to the third genetic locus affecting coat colour will be evident. This locus is recognised as affecting coat colour through the expression of pheomelanin, the pigment responsible for red and yellow pigmentation. The effects on pheomelanin pigmentation are only seen
Lycopene pressure, interactions with drugs that affect blood pressure may occur. Lycopene may affect the immune system, the nervous system, sensitivity to sunlight, or drugs used for stomach ailments. Lycopenemia is an orange discoloration of the skin that is observed with high intakes of lycopene. The discoloration is expected to fade after discontinuing excessive lycopene intake. In a review of literature on lycopene and its potential role as a dietary antioxidant, the European Food Safety Authority concluded that evidence was insufficient for lycopene having antioxidant effects in humans, particularly in skin, heart function, or vision protection from ultraviolet light. Although lycopene