Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
What Bird is That? author Nick Earls' 1999 young adult novel "48 Shades of Brown". The 48 shades refers to the number of distinct browns used by Cayley to describe bird plumage colours. What Bird is That? What Bird is That? A Guide to the Birds of Australia is a book first published in 1931 by Angus & Robertson in Sydney. Authored and illustrated by Neville William Cayley, it was Australia’s first fully illustrated national field guide to birds, a function it served alone for nearly 40 years. In 1960 it was rated the all-time best seller in Australian natural history. "What Bird Is