Drug injection taking drugs, injection is favoured by some people as the full effects of the drug are experienced very quickly, typically in five to ten seconds. It also bypasses first-pass metabolism in the liver, resulting in higher bioavailability and efficiency for many drugs (such as morphine or diacetylmorphine/heroin; roughly two-thirds of which is destroyed in the liver when consumed orally) than oral ingestion would. The effect is that the person gets a stronger (yet shorter-acting) effect from the same amount of the drug. Drug injection is therefore often related to substance dependence. In a recreational context, the shorter, more intense "high"
Arguments for and against drug prohibition accidents while intoxicated or violence and aggression, are more likely to figure in the longer term, just as with tobacco, where both nicotine overdose and cannabis overdose are extremely rare or nonexistent. While ecstasy may have lower rates of immediate mortality than some other illicits, there is a growing science on the already recognized considerable health harms of ecstasy. Drug Free Australia argues that distinctions between "soft" and "hard" drugs are entirely artificial, and titling cannabis "soft" or ecstasy "recreational" does not lessen the extensive harms of these substances. Gil Kerlikowske, director of the US Office of National Drug Control