Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Sphere sphere orthogonal to any two spheres of a pencil of spheres is orthogonal to all of them and its center lies in the radical plane of the pencil. Pairs of points on a sphere that lie on a straight line through the sphere's center are called antipodal points. A great circle is a circle on the sphere that has the same center and radius as the sphere and, consequently, divides it into two equal parts. The plane sections of a sphere are called "spheric sections". They are all circles and those that are not great circles are called "small circles".