Benue Trough the Central African Shear Zone and for the volcanic island of St. Helena in the Atlantic ocean. Three periods of magmatic activity (volcanic action) have been identified, 147–106 Ma, 97–81 Ma and 68–49 Ma. The first is prominent in the north of the trough, and contemporary with magmatism in Brazil, probably occurring during a period of crustal extension before the Atlantic started to open. The second is found only in the south of the trough, and may belong to a period when the extension of the Atlantic had slowed down, ending with a period of compression. The third and last
Trough level metabolized or cleared by the body, so the concentration of drug that remains available is dropping. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. A trough level is contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Trough level In medicine and