Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Public sphere pedagogy sphere pedagogy might alienate students and community members unaccustomed to this type of dialectic experience. In addition to its exclusionary nature, attention has also been called to Habermas' privileging of a hegemonic public sphere. Michael Warner argues that the bourgeois public sphere was structured to be affable to those privileged few who made up the powerful upperclass. While students participating in public sphere pedagogy application receive special training in their classrooms, the same is not necessarily true of community members who participate. This specialized student training draws two critiques. First, conceiving of public pedagogy as a form of instruction risks