Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Sphere space with possible self-intersections but without creating any crease, in a process called sphere eversion. The basic elements of Euclidean plane geometry are points and lines. On the sphere, points are defined in the usual sense. The analogue of the "line" is the geodesic, which is a great circle; the defining characteristic of a great circle is that the plane containing all its points also passes through the center of the sphere. Measuring by arc length shows that the shortest path between two points lying on the sphere is the shorter segment of the great circle that includes the points.