Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Inscribed sphere For such cases, the notion of an insphere does not seem to have been properly defined and various interpretations of an "insphere" are to be found: Often these spheres coincide, leading to confusion as to exactly what properties define the insphere for polyhedra where they do not coincide. For example, the regular small stellated dodecahedron has a sphere tangent to all faces, while a larger sphere can still be fitted inside the polyhedron. Which is the insphere? Important authorities such as Coxeter or Cundy & Rollett are clear enough that the face-tangent sphere is the insphere. Again, such authorities agree