Kype Kype A kype is a hook-like secondary sex characteristic which develops at the distal tip of the lower jaw in some male salmonids prior to the spawning season. The structure usually develops in the weeks prior to, and during, migration to the spawning grounds. In addition to the development of the kype, a large depression forms in the two halves of the premaxilla in the upper jaw, allowing the kype to fit into the premaxilla when the mouth is closed. The kype functions as a secondary sexual characteristic and influences the formation of dominance hierarchies at the spawning grounds. The
Medication-associated osteonecrosis of the jaw of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs. This condition was previously known as bisphosphonate-related osteonecrosis of the jaw because osteonecrosis of the jaws correlating with bisphosphate treatment was frequently encountered, with its first incident occurring in 2003. Denosumab, another antiresorptive drug were also related to this condition. However, newer medications such as anti-angiogenic drugs has been established over the years which were reported to be related to osteonecrosis of the jaw as a side-effect too, hence this condition has been renamed as MRONJ. BON was nicknamed "bis-phossy jaw" based on its similarity with phossy jaw. There is no