Schistosomiasis artesunate, or mefloquine. A Cochrane review found tentative evidence that when used alone, metrifonate was as effective as praziquantel. Another agent, mefloquine, which has previously been used to treat and prevent malaria, was recognised in 2008–2009 to be effective against "Schistosoma". Historically, antimony potassium tartrate remained the treatment of choice for schistosomiasis until the development of praziquantel in the 1980s. The disease is found in tropical countries in Africa, the Caribbean, eastern South America, Southeast Asia, and the Middle East. "S. mansoni" is found in parts of South America and the Caribbean, Africa, and the Middle East; "S. haematobium" in
International Association for the Treatment of Sexual Offenders and treatment targets (such as cognitive distortions). Responsivity issues are the parts that affect how much the client(s) benefit or fail to benefit from the treatment and care programs. This proves that the treatment of sexual offenders has to be specific and different than another offenders treatment. Treatment of sexual offenders is very complicated and it is crucial to take the proper guidelines for the treatment to not only be successful but also to be long-lasting. Youths between the ages of 12-18 who have been either officially charged with a sexual crime or have performed an act that could be