Mefloquine in "Pfmdr1" copy number. Mefloquine is contraindicated in those with a previous history of seizures or a recent history of psychiatric disorders. Severe side effects requiring hospitalization are rare. Compared to other malaria prophylaxis regimens, mefloqinone may produce more side effects in non-pregnant travelers. In pregnant travelers, it appears to pose minimal risk to the fetus. In 2013 the United States Food and Drug Administration added a boxed warning to the U.S. label of mefloquine regarding the potential for neuropsychiatric side effects that may persist even after discontinuing administration of the drug. Psychiatric effects include nightmares, visual and auditory hallucinations,
The Old Blue Mayor She Ain't What She Used to Be tonight, flock to Marge not because she’s clearly a better candidate and person than perennially elected, womanizing, cartoonishly corrupt Diamond Joe Quimby, but because resident political operative Lindsey Naegle convinces her to use Professor Frink’s micro-targeted campaigning." "The Old Blue Mayor She Ain't What She Used to Be" scored a 1.9 rating with a 7 share and was watched by 4.75 million people, making it Fox's highest rated show of the night. The Old Blue Mayor She Ain't What She Used to Be "The Old Blue Mayor She Ain't What She Used to Be" is the sixth episode of the