Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Inscribed sphere For such cases, the notion of an insphere does not seem to have been properly defined and various interpretations of an "insphere" are to be found: Often these spheres coincide, leading to confusion as to exactly what properties define the insphere for polyhedra where they do not coincide. For example, the regular small stellated dodecahedron has a sphere tangent to all faces, while a larger sphere can still be fitted inside the polyhedron. Which is the insphere? Important authorities such as Coxeter or Cundy & Rollett are clear enough that the face-tangent sphere is the insphere. Again, such authorities agree