Systems theory to social sciences (see David Easton's seminal development of the "political system" as an analytical construct), the original theorists explored the implications of twentieth century advances in terms of systems. People have studied subjects like complexity, self-organization, connectionism and adaptive systems in the 1940s and 1950s. In fields like cybernetics, researchers such as Norbert Wiener, William Ross Ashby, John von Neumann and Heinz von Foerster, examined complex systems mathematically. John von Neumann discovered cellular automata and self-reproducing systems, again with only pencil and paper. Aleksandr Lyapunov and Jules Henri Poincaré worked on the foundations of chaos theory without any computer
Alexander S. Wiener in numerous investigations by analyzing the blood (or related fluids) of those involved. Numerous articles and chapters of books with real life crime stories were written about Dr. Wiener's work in criminology. Along with his father, George Wiener, a lawyer. Wiener helped draft a new set of laws addressing the recent scientific advancements in blood identification. He was a member of the American Medical Association legal committee that sponsored blood test laws in all states, and he was the co-author of its 1935 report. His work in the genetics of the blood factors also allowed him to be of assistance