Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Public sphere pedagogy opinion through critical rational discourse. Habermas argued that these discussions served to fill the gap between the state and the people by creating what he called a "civil society". Further, Habermas argued that a functioning public sphere was critical to maintaining a healthy democratic order and deliberative democracy. This traditional notion of a face-to-face public sphere has evolved with the invention of online technologies. The public sphere no longer requires a physical setting, but can manifest in cyberspace. The coffee house discussions idealized by Habermas have expanded to blogs, discussion forums, and online videos. Henry Giroux in particular discusses the