Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Sphere The shortest distance along the surface between two distinct non-antipodal points on the sphere is the length of the smaller of the two arcs on the unique great circle that includes the two points. Equipped with this "great-circle distance", a great circle becomes the Riemannian circle. If a particular point on a sphere is (arbitrarily) designated as its "north pole", then the corresponding antipodal point is called the "south pole", and the equator is the great circle that is equidistant to them. Great circles through the two poles are called lines (or meridians) of longitude, and the line connecting the