Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Kline sphere characterization Kline sphere characterization In mathematics, a Kline sphere characterization, named after John Robert Kline, is a topological characterization of a two-dimensional sphere in terms of what sort of subset separates it. Its proof was one of the first notable accomplishments of R. H. Bing; Bing gave an alternate proof using brick partitioning in his paper "Complementary domains of continuous curves" A simple closed curve in a two-dimensional sphere (for instance, its equator) separates the sphere into two pieces upon removal. If one removes a pair of points from a sphere, however, the remainder is connected. Kline's sphere characterization states that