Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Sphere (novel) film by Andrei Tarkovsky". Reviews were mostly positive for the novel. "The New York Times" Robin McKinley said, "Part of the fun of "Sphere" is that it keeps you going even when you're pretty sure of what will happen next." Sphere (novel) Sphere is a novel written by author Michael Crichton that was published in 1987. The novel was adapted into the film "Sphere" in 1998. The story follows Norman Johnson, a psychologist engaged by the United States Navy, who joins a team of scientists assembled to examine a spacecraft of unknown origin discovered on the bottom of the Pacific