Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Pith and substance circumscribed. Cases relating to Pith and Substance.- Citation in the matter of M/s. Sky Gourmet Catering Private Limited V/s Tax Authorities (Commercial Tax and Service Tax) in the matter of Writ Appeal No. 671 to 726 of 2011 (T-Res) decided on 18th day of April, 2011 by Hon'ble High Court of Karnataka at Bangalore may also be seen. Pith and substance Pith and substance is a legal doctrine in Canadian constitutional interpretation used to determine under which head of power a given piece of legislation falls. The doctrine is primarily used when a law is challenged on the basis that