Labrador Retriever coat colour genetics fur colour but those with black skin can potentially produce a Dudley. Dudleys breed true for both fur and skin. The ability of the E locus to override the coat colour directed by the B locus is a classical example of epistasis, where multiple genetic loci affect the same observed trait. The E locus also determines whether the phenotype due to the third genetic locus affecting coat colour will be evident. This locus is recognised as affecting coat colour through the expression of pheomelanin, the pigment responsible for red and yellow pigmentation. The effects on pheomelanin pigmentation are only seen
Blue Is the Warmest Colour the Warmest Color" through The Criterion Collection on 25 February 2014. As "Blue Is the Warmest Colour", the film was also released on DVD and Blu-ray Disc in Canada on 25 February 2014 by Mongrel Media, in the United Kingdom on 17 March 2014 by Artificial Eye and on 18 June 2014 in Australia by Transmission Films. In Brazil, Blu-ray manufacturing companies Sonopress and Sony DADC are refusing to produce the film because of its content. The distributor is struggling to reverse this situation. "Blue Is the Warmest Colour" grossed a worldwide total of $19,492,879. During its opening in France,