Mefloquine during the study. Mefloquine was the first Public-Private Venture (PPV) between the US Department of Defense and a pharmaceutical company. WRAIR transferred all its phase I and phase II clinical trial data to Hoffman LaRoche and Smith Kline. FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. The drug was first approved and sold on a commercial basis in Switzerland in 1985. However, mefloquine was not approved by the FDA for prophylactic use until 1989. This approval was based primarily on compliance, while safety and tolerability were overlooked. Because of
What the World Needs Now Is Love assassination, and Martin Luther King, Jr., and soundbites of news coverage of each assassination. The ending of the song is a reprise of the introduction. "What the World Needs Now is Love/Abraham, Martin and John" rose to No. 8 on the "Billboard" Hot 100 in August 1971, and was Clay's only Top 40 hit. "What the World Needs Now is Love" has been used in many film soundtracks, notably "Bob & Carol & Ted & Alice" and "For the Love of Fred" (used as the film's closing theme song in both), "", "My Best Friend's Wedding", "", "The Boss Baby",