Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
Murder Ain't What it Used to Be Murder Ain't What it Used to Be Murder Ain't What it Used to Be is the seventh episode of the popular 1969 ITC British television series "Randall and Hopkirk (Deceased)" starring Mike Pratt, Kenneth Cope and Annette Andre. Directed by Jeremy Summers, the episode was first broadcast on 2 November 1969 on ITV. Crime boss Paul Kirstner flies over to Great Britain from New York City to attend to "business" in London. Behind most of the rackets in Chicago, he hires Jeff to protect his daughter from any of his enemies whilst in London. However, Kirstner is being haunted by