Castoreum is very low, around 300 pounds, whereas vanillin is over 2.6 million pounds annually. Castoreum has been traditionally used in Sweden for flavoring schnapps commonly referred to as "Bäverhojt" (literally, "beaver shout"). Castoreum is also used to contribute to the flavor and odor of cigarettes. Medieval beekeepers used castoreum to increase honey production. Castoreum Castoreum is a yellowish exudate from the castor sacs of the mature North American beaver ("Castor canadensis") and the European beaver ("Castor fiber"). Beavers use castoreum in combination with urine to scent mark their territory. Both beaver sexes have a pair of castor sacs and a
Ground substance as hyaluronic acid, heparan sulfate, dermatan sulfate, and chondroitin sulfate, proteoglycans which GAGs are bound to, and glycoproteins. Components of the ground substance are secreted by fibroblasts. Usually it is not visible on slides, because it is lost during staining in the preparation process. Link proteins such as vinculin, spectrin and actomyosin stabilize the proteoglycans and organize elastic fibers in the ECM. Changes in the density of ground substance can allow collagen fibers to form aberrant cross-links. Loose connective tissue is characterized by few fibers and cells, and a relatively large amount of ground substance. Dense connective tissue has a