Mefloquine during the study. Mefloquine was the first Public-Private Venture (PPV) between the US Department of Defense and a pharmaceutical company. WRAIR transferred all its phase I and phase II clinical trial data to Hoffman LaRoche and Smith Kline. FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. The drug was first approved and sold on a commercial basis in Switzerland in 1985. However, mefloquine was not approved by the FDA for prophylactic use until 1989. This approval was based primarily on compliance, while safety and tolerability were overlooked. Because of
The Treatment Trap The Treatment Trap The Treatment Trap - How the Overuse of Medical Care is Wrecking your Health and what you can do to Prevent it is a 2010 book by Rosemary Gibson and Janardan Prasad Singh about unnecessary health care. AARP described the book as an exploration of "the reasons why many physicians are overly cautious, incompetent, or under great pressure to produce revenues in a health care system that seems to encourage these practices". A magazine review said that the message of the book was that "When it comes to health care, more is not always better." A reviewer