Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Circle of a sphere there is exactly one circle that can be drawn through three given points. The proof can be extended to show that the points on a circle are all a common angular distance from one of its poles. To show that a non-trivial intersection of two spheres is a circle, assume (without loss of generality) that one sphere (with radius formula_1) is centered at the origin. Points on this sphere satisfy Also without loss of generality, assume that the second sphere, with radius formula_3, is centered at a point on the positive x-axis, at distance formula_4 from the origin. Its points