Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Inscribed sphere Inscribed sphere In geometry, the inscribed sphere or insphere of a convex polyhedron is a sphere that is contained within the polyhedron and tangent to each of the polyhedron's faces. It is the largest sphere that is contained wholly within the polyhedron, and is dual to the dual polyhedron's circumsphere. The radius of the sphere inscribed in a polyhedron "P" is called the inradius of "P". All regular polyhedra have inscribed spheres, but most irregular polyhedra do not have all facets tangent to a common sphere, although it is still possible to define the largest contained sphere for such shapes.