Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Shadow and Substance Shadow and Substance "Shadow and Substance "is an award-winning four-act play written in 1937 by Paul Vincent Carroll. In 1938 it won the New York Drama Critics' Circle award for best foreign play. First published by Samuel French in 1944. Set in Ireland, the play has a cast of six men and four women. According to George Jean Nathan "deals with the Catholic Church in Ireland. Its theme lies in the ramifications of faith as practiced by the Church's various constituents…faith that, for all its sincerity, has drifted from its deepest moorings, and the manner in which a true, steadfast,