Half sphere exposure Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to the Cβ-Cα vector. This simple division of the CN sphere results in two strikingly different measures, HSE-up and HSE-down. HSE-up is defined
Sphere -ball; thus, it is homeomorphic to the Euclidean -sphere, but perhaps lacking its metric. The -sphere is denoted . It is an example of a compact topological manifold without boundary. A sphere need not be smooth; if it is smooth, it need not be diffeomorphic to the Euclidean sphere. The Heine–Borel theorem implies that a Euclidean -sphere is compact. The sphere is the inverse image of a one-point set under the continuous function . Therefore, the sphere is closed. is also bounded; therefore it is compact. Remarkably, it is possible to turn an ordinary sphere inside out in a three-dimensional