PH the Hammett acidity function, "H", has been developed in connection with superacids. The concept of "unified pH scale" has been developed on the basis of the absolute chemical potential of the proton. This model uses the Lewis acid–base definition. This scale applies to liquids, gases and even solids. In 2010, a new "unified absolute pH scale" has been proposed that would allow various pH ranges across different solutions to use a common proton reference standard. Pure water is neutral. When an acid is dissolved in water, the pH will be less than 7 (25 °C). When a base, or alkali,
Esophageal pH monitoring hydrochloric acid in the distal esophagus. Formal measurement of acid in the esophagus was first described in 1960 by Tuttle. He used a glass pH probe to map the gastroesophageal pH gradient, and demonstrated a sharp gradient in normal subjects and a gradual sloping gradient in patients with esophagitis. Four years later, Miller used an indwelling esophageal pH electrode to continuously measure esophageal and gastric pH for a period up to 12 hours. This technique required that the patient keep their hands immersed in saline to serve as a reference. Prolonged monitoring became feasible in 1974 when Johnson and DeMeester