Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
International Association for the Treatment of Sexual Offenders two people need to have a strong relationship in order for the offenders to trust the clinicians), break up and mechanistic treatment delivery. The goals of sexual offender treatment is to achieve a goal that the offender has been working toward, which most of the time the goal is to not reoffend. This can be achieved by giving them hope, gaining self-esteem, making goals, creating strong relationships, and also working with the offender regularly. When it comes to the general criminal population treatment focuses on risk, need, and responsivity. However, when applied to sexual offenders two problems are risk assessment