Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
What Is This Thing Called Love? What Is This Thing Called Love? "What Is This Thing Called Love?" is a 1929 popular song written by Cole Porter, for the musical "Wake Up and Dream". It was first performed by Elsie Carlisle in March 1929. The song has become a popular jazz standard and one of Porter's most often played compositions. "Wake Up and Dream" ran for 263 shows in London. The show was also noticed in New York, and the critics praised Tilly Losch's performance of the song. The show was produced on Broadway in December 1929; in the American rendition, "What Is This Thing Called