Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
3-sphere of the three-sphere. Here we describe gluing a pair of three-balls and then the one-point compactification. A 3-sphere can be constructed topologically by "gluing" together the boundaries of a pair of 3-balls. The boundary of a 3-ball is a 2-sphere, and these two 2-spheres are to be identified. That is, imagine a pair of 3-balls of the same size, then superpose them so that their 2-spherical boundaries match, and let matching pairs of points on the pair of 2-spheres be identically equivalent to each other. In analogy with the case of the 2-sphere (see below), the gluing surface is called