Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
3-sphere centered at the origin with radius 1 is called the unit 3-sphere and is usually denoted : It is often convenient to regard as the space with 2 complex dimensions () or the quaternions (). The unit 3-sphere is then given by or This description as the quaternions of norm one identifies the 3-sphere with the versors in the quaternion division ring. Just as the unit circle is important for planar polar coordinates, so the 3-sphere is important in the polar view of 4-space involved in quaternion multiplication. See polar decomposition of a quaternion for details of this development of