Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
What is a Masterpiece? What is a Masterpiece? What is a Masterpiece? is a 1979 non-fiction book by British historian Kenneth Clark. It is a transcribed version of the Walter Neurath memorial lectures given by Clark. The work, initially released on 1 January 1979, received a Thames & Hudson republication on 1 May 1992. Kenneth Clark had already achieved fame with a series of popular books while also serving as, from 1969 on, the writer, producer and presenter of the BBC programme, "Civilisation", a pioneering television documentary series. The prestigious series earned a Peabody Award as well as general commercial success. In the work,