Mefloquine the drug's very long half-life, the Centers for Disease Control originally recommended a mefloquine dosage of 250 mg every two weeks; however, this caused an unacceptably high malaria rate in the Peace Corps volunteers who participated in the approval study, so the drug regimen was switched to once a week. The first randomized, controlled trial on a mixed population was performed in 2001. Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71% in the atovaquone-proguanil arm. In the mefloquine arm, 5%
Wastewater treatment Wastewater treatment Waste water treatment is a process used to convert wastewater into an effluent that can be returned to the water cycle with minimum impact on the environment, or directly reused. The latter is called water reclamation because treated wastewater can then be used for other purposes. The treatment process takes place in a wastewater treatment plant (WWTP), often referred to as a Water Resource Recovery Facility (WRRF) or a sewage treatment plant. Pollutants in municipal wastewater (households and small industries) are removed or broken down. The treatment of wastewater is part of the overarching field of sanitation. Sanitation