Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
3-sphere homeomorphic to the one-point compactification of . In general, any topological space that is homeomorphic to the 3-sphere is called a topological 3-sphere. The homology groups of the 3-sphere are as follows: and are both infinite cyclic, while for all other indices . Any topological space with these homology groups is known as a homology 3-sphere. Initially Poincaré conjectured that all homology 3-spheres are homeomorphic to , but then he himself constructed a non-homeomorphic one, now known as the Poincaré homology sphere. Infinitely many homology spheres are now known to exist. For example, a Dehn filling with slope on any