Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Castor and Pollux (Prado) Castor and Pollux (Prado) The Castor and Pollux group (also known as the San Ildefonso Group, after San Ildefonso in Segovia, Spain, the location of the palace of La Granja at which it was kept until 1839) is an ancient Roman sculptural group of the 1st century AD, now in the Museo del Prado, Madrid. Drawing on 5th- and 4th-century BC Greek sculptures in the Praxitelean tradition, such as the Apollo Sauroctonos and the "Westmacott Ephebe", and without copying any single known Greek sculpture, it shows two idealised nude youths, both wearing laurel wreaths. The young men lean against each