Half sphere exposure both HSEα and HSEβ based on a big dataset by using multiple-step iterative deep neural-network learning. The predicted HSEa shows a higher correlation coefficient to the stability change by residue mutants than predicted HSEβ and ASA. The results, together with its easy Ca-atom-based calculation, highlight the potential usefulness of predicted HSEa for protein structure prediction and refinement as well as function prediction. Half sphere exposure Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by . Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found
Science On a Sphere This work enabled MacDonald's invention to move out from the laboratory and into performance spaces. A patent was awarded to NOAA for Science On a Sphere in August 2005, with MacDonald credited as the inventor. General system architecture and configuration specifications are as follows. The carbon fiber sphere is in diameter. Other sphere sizes are possible, such as 48" and 60". Larger sizes are possible too. The 68" sphere with a single seam at the equator weighs under . The sphere is attached to the ceiling or suspension structure with a three-point suspension system to hold the sphere in place