Half sphere exposure used in predicting discontinuous B-cell epitopes. Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure. Recently, Heffernan et al. has developed the most accurate predictor for
Simplicial sphere "i"-faces of any simplicial "d"-sphere with "f" = "n" vertices. This conjecture was proved for polytopal spheres by Peter McMullen in 1970 and by Richard Stanley for general simplicial spheres in 1975. The g"-conjecture, formulated by McMullen in 1970, asks for a complete characterization of "f"-vectors of simplicial "d"-spheres. In other words, what are the possible sequences of numbers of faces of each dimension for a simplicial "d"-sphere? In the case of polytopal spheres, the answer is given by the g"-theorem, proved in 1979 by Billera and Lee (existence) and Stanley (necessity). It has been conjectured that the same conditions