Beaver extinction in part for the production of castoreum, which was used as an analgesic, anti-inflammatory, and antipyretic. Castoreum was described in the 1911 British Pharmaceutical Codex for use in dysmenorrhea and hysterical conditions (i.e. pertaining to the womb), for raising blood pressure and increasing cardiac output. The activity of castoreum has been credited to the accumulation of salicin from willow trees in the beaver's diet, which is transformed to salicylic acid and has an action very similar to aspirin. Castoreum continues to be used in perfume production. Castoreum can be used as an enhancer of vanilla, strawberry and raspberry flavorings.
Pith and substance Pith and substance Pith and substance is a legal doctrine in Canadian constitutional interpretation used to determine under which head of power a given piece of legislation falls. The doctrine is primarily used when a law is challenged on the basis that one level of government (be it provincial or federal) has encroached upon the exclusive jurisdiction of another level of government. The Constitution Act, 1867, which established a federal constitution for Canada, enumerated in Sections 91 and 92 the topics on which the Dominion and the Provinces could respectively legislate. Notwithstanding that the lists were framed so as to