Acetophenone is also a component of castoreum, the exudate from the castor sacs of the mature beaver. In the late 19th and early 20th centuries, acetophenone was used in medicine. It was marketed as a hypnotic and anticonvulsant under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters. It was considered to have superior sedative effects to both paraldehyde and chloral hydrate. In humans, acetophenone is metabolized to benzoic acid, carbonic acid, and acetone. Hippuric acid occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure, although other substances, like toluene, also
Perfume used as middle notes. Manufacturers who publish perfume notes typically do so with the fragrance components presented as a "fragrance pyramid", using imaginative and abstract terms for the components listed. Grouping perfumes can never be a completely objective or final process. Many fragrances contain aspects of different families. Even a perfume designated as "single flower", however subtle, will have undertones of other aromatics. "True" unitary scents can rarely be found in perfumes as it requires the perfume to exist only as a singular aromatic material. Classification by olfactive family is a starting point for a description of a perfume, but