Shingles caused by varicella-zoster was regarded as rare disease, mostly related to childhood chickenpox. However, meningoencephalitis caused by varicella-zoster is increasingly recognized as a predominant cause of ME among immunocompetent adults in non-epidemic circumstances. Diagnosis of complications of varicella-zoster, particularly in cases where the disease reactivates after years or decades of latency, are difficult. A rash (shingles) can be present or absent. Symptoms vary, and there is significant overlap in symptoms with herpes-simplex symptoms. Although DNA analysis techniques such as polymerase chain reaction (PCR) can be used to look for DNA of herpesviruses in spinal fluid or blood, the results may
Motor neuron disease Motor neuron disease Motor neuron diseases (MNDs) are a group of neurodegenerative disorders that selectively affect motor neurons, the cells which control voluntary muscles of the body. Commonly, the following disorders are counted among motor neuron diseases: The term “motor neuron disease” sometimes refers to ALS, but in this article, the term refers to a group of diseases listed above, which includes ALS. Motor neuron diseases affect both children and adults. While each motor neuron disease affects patients differently, they all cause movement-related symptoms, mainly muscle weakness. Most diseases seem to occur randomly without known causes, but some forms are