Cold War tensions and the polio vaccine Cold War tensions and the polio vaccine Polio (Infantile paralysis or poliomyelitis) epidemics were a concern during the summer months for children globally, with records of polio from the Egyptians and Greeks to the 1950s epidemics. In the summer of 1921, this epidemic became notorious when Franklin Delano Roosevelt, the Democratic contender for the vice presidency, was struck down by polio at the age of 39. Two U.S. virologists, Jonas Salk of the University of Pittsburgh and Albert B. Sabin of the University of Cincinnati emerged as the most prominent among dozens of American researchers on the quest for a
Smallpox vaccine sheep were used. In the late 1940s and early 1950s, Leslie Collier, an English microbiologist working at the Lister Institute of Preventive Medicine, developed a method for producing a heat-stable freeze-dried vaccine in powdered form. Collier added 0.5% phenol to the vaccine to reduce the number of bacterial contaminants but the key stage was to add 5% peptone to the liquid vaccine before it was dispensed into ampoules. This protected the virus during the freeze drying process. After drying the ampoules were sealed under nitrogen. Like other vaccines, once reconstituted it became ineffective after 1–2 days at ambient temperatures. However,