Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard the Iroquois and Boone. Omri uses the trunk to bring Patrick back to the present and at the same time return the Iroquois to the past, but returning Patrick inadvertently drags the tornado back to Omri's room, destroying part of the house and neighborhood. In the chaos, the cupboard is damaged and the key lost. Omri's headmaster, who has been lurking outside the house hoping to catch evidence of Omri's secret, is struck on the head by debris, meaning that no one believes any of his ramblings about "tiny people." Boone and Ruby Lou realize they are stranded as tiny