Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Albert Kapikian Albert Kapikian Albert Zaven Kapikian (1930 – 2014) was an Armenian-American virologist who developed the first licensed vaccine against rotavirus, the most common cause of severe diarrhea in infants. He was awarded the Sabin Gold Medal for his pioneering work on the vaccine. He is the 13th recipient of this recognition, awarded annually by the Sabin Vaccine Institute. Called the father of human gastroenteritis virus research, Kapikian identified the first norovirus, initially called Norwalk virus, in 1972; and he and his colleagues at the National Institutes of Health identified the hepatitis A virus in 1973. Kapikian graduated from Cornell Medical