Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Skeleton in the Cupboard (Yes Minister) The Skeleton in the Cupboard (Yes Minister) "The Skeleton in the Cupboard" is the seventeenth episode of the BBC comedy series "Yes Minister" and was first broadcast 25 November 1982. Jim Hacker is chairing a meeting with his senior officials. One item on the agenda is the disciplinary action to be taken against the South Derbyshire local authority for failing to complete its statutory returns and supply required information. Sir Humphrey Appleby regards this as a serious matter. Around the table, several examples of "incompetence" are given and the Minister wishes to know of any "redeeming features". One of the