Shingles caused by varicella-zoster was regarded as rare disease, mostly related to childhood chickenpox. However, meningoencephalitis caused by varicella-zoster is increasingly recognized as a predominant cause of ME among immunocompetent adults in non-epidemic circumstances. Diagnosis of complications of varicella-zoster, particularly in cases where the disease reactivates after years or decades of latency, are difficult. A rash (shingles) can be present or absent. Symptoms vary, and there is significant overlap in symptoms with herpes-simplex symptoms. Although DNA analysis techniques such as polymerase chain reaction (PCR) can be used to look for DNA of herpesviruses in spinal fluid or blood, the results may
European Centre for Disease Prevention and Control The office of the Chief Scientist oversees the seven Disease Programmes, the Microbiology Coordination Section and the Scientific Advice Coordination Section. The Disease Programmes focus on specific disease groups: Two shared-resource units – Surveillance and Response Support, and Public Health Capacity and Communication – provide specialist expertise. The Information and Communication Technologies Unit provides infrastructure, application development and support. The Resource Management and Coordination Unit controls ECDC’s human and financial resources. ECDC publishes numerous scientific and technical reports covering various issues related to the prevention and control of communicable diseases. Comprehensive reports from key technical and scientific meetings are also