Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard (film) Bear tells Omri to send the man back, but Omri is reluctant, worried that no one will find his body if he was alone when Omri summoned him. Little Bear yells at Omri, saying that he, Little Bear, had been guiding his nephew through the woods to teach him how to be a man when Omri had taken him away and that Omri shouldn't tamper with magic he doesn't even understand. This upsets Omri. Omri locks the dead Chieftain in the cupboard, making him plastic once more, before leaving the angry Little Bear to answer his dad calling him downstairs.