Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard cupboard. Omri believes that the final bundle must contain the missing earrings, but in fact, it contains another tiny person, fast asleep. Before he can investigate further, he is called to Tom's home. Tom has fallen from the roof and is on the verge of death, but asked for Omri to tell him the final secret: before she died, Jessica had him search for a plastic figure of herself. He bought dozens of figurines before finally finding the right one. Jessica kept the figure of herself but told him to take care of the other plastic figures, saying, "This is