Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
Hib Sabin Hib Sabin Hib Sabin (born 1935) is an American sculptor and educator. He is known for his indigenous-style work in juniper wood. He carves spirit animal spirit bowls, spirit canoes, dream and dance sticks, and shamanistic masks. He lives in Santa Fe, New Mexico. Sabin received a BFA in Studio Art and Art History from University of Pennsylvania / Pennsylvania Academy of Fine Arts (coordinated program) and an MFA in Art History from the University of Pittsburgh. Sabin has taught art history at Shadyside Academy in Pittsburgh and at Franklin and Marshall College in Lancaster, Pennsylvania. He was an Associate