Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard (film) the cupboard and keep the Indian a secret. When Omri arrives home from school, he is upset to discover that the Indian has returned to its original toy form. When he goes to bed, Omri once more hears the tapping noise he heard that morning. He opens the cupboard to find the Indian alive once more. The Indian is again initially frightened of Omri but warms up to him, thinking Omri is a great spirit in a child's form, as the two begin talking, slowly forming a friendship. The Indian reveals himself as an English-speaking, 18th-century Iroquois Indian named Little