TARDIS to those first seen in 1963, with multiple roundels illuminated from behind. The fourth major redesign of the TARDIS in the revived series appeared in the eleventh series. New production designer Arwel Wyn Jones said that the inspiration for the Thirteenth Doctor's TARDIS was based on the 2005-10 model, which he had worked on. The console room is the "safest place on the ship," and so when its occupants are in danger the TARDIS will reinvent its architecture so as to allow them to enter the console room. This can also result in the TARDIS materialising itself within its own
Circular permutation in proteins a class of proteins involved in sphingolipid catabolism and antigen presentation of lipids in humans. Chris Ponting and Robert Russell identified a circularly permuted version of a saposin inserted into plant aspartic proteinase, which they nicknamed swaposin. Saposin and swaposin were the first known case of two natural genes related by a circular permutation. Hundreds of examples of protein pairs related by a circular permutation were subsequently discovered in nature or produced in the laboratory. As of February 2012, the Circular Permutation Database contains 2,238 circularly permuted protein pairs with known structures, and many more are known without structures. The