Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
His Name Is... Savage and bloody crushed hand and another showing a metal gun-barrel smashing through a man's teeth and sending teeth flying. "Savage depends on only two things: guts and his .357 magnum, which he has no compunction about using," one critic wrote of the 1982 reissue. "Broken noses, splintering teeth, and splattering brains are all depicted in lurid detail They are part and parcel of Savage's obdurate attempts to stop a madman from instigating World War III. Although this is an old theme, Kane and Goodwin present a tale that is riveting and upsettingly believable." Fantagraphics Books reprinted "His Name Is... Savage"