Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
Albert Bruce-Joy Albert Bruce-Joy Albert Bruce-Joy (21 August 1842 – 22 July 1924) was an Irish sculptor working in England. His original surname was Joy but he became known under his hyphenated name Bruce-Joy later in life. He was the brother of the painter George W. Joy. Son of William Bruce Joy, MD, Bruce-Joy was born in Dublin but educated in Offenbach, Paris and at King's College London. He trained as a sculptor with John Henry Foley at the National Art Training School, South Kensington, and the Royal Academy Schools. He began exhibiting at the Royal Academy from 1866 onwards. In 1867