Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
David Bruce (microbiologist) tsetse fly vector, of African trypanosomiasis ("sleeping sickness"). He was Surgeon-General for the duration of the First World War from 1914–19 at the Royal Army Medical College, Millbank, London. "Brucella" is the genus and Brucellaceae is the family of the bacteria which was named after him, in recognition of his discoveries. "Brucella melitensis" is the cause of undulant fever in man and of abortion in goats. It is usually transmitted by goat's milk. "Trypanosoma brucei", the cause of sleeping sickness, is also named after him. Bruce was elected a Fellow of the Royal Society (FRS) in 1899. He served as