Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard book, Omri receives wins first prize in a story-writing competition for his tale "The Plastic Indian," which is actually a recounting of his real adventures with the cupboard; everyone else assumes that Omri's story is fictional. Wanting to share his good news, Omri brings Little Bear and Bright Stars through the magic cupboard. Little Bear returns badly injured by the French soldiers he has been fighting in his own time. Omri attempts to bring back Tommy, the WWI field medic from the first book, but receives only Tommy's neatly folded uniform and medical bag, causing him to realized that Tommy