Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Sabin Vaccine Institute contribution to the field of vaccinology or related fields. The award is given in honor of the work of Albert B. Sabin. Past recipients of the award include Samuel L. Katz (2003), Joseph L. Melnick (1996), and Ruth S. Nussenzweig (2008). Sabin Vaccine Institute Sabin Vaccine Institute (Sabin), located in Washington, D.C., is a nonprofit (501(c)(3)) organization promoting global vaccine development, availability, and use. Through its work, Sabin hopes to reduce human suffering by preventing the spread of vaccine-preventable, communicable disease in humans through herd immunity, and also hopes to mitigate the poverty caused by these diseases. Founded in 1993