Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard all to life with the cupboard to serve as Little Bear's army. They also buy plastic miniatures of modern guns to give to the Iroquois, as well as a miniature Royal Marine figurine (who turns out to be a British corporal named Fickits) to instruct the Iroquois in their use. After Little Bear and his troops are sent back, a casual comment by Boone prompts Omri and Patrick to wonder if it is the key which is magical, rather than the cupboard. Omri climbs into a large empty chest while holding Little Bear's plastic tipi and has Patrick turn the