Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard turn out to be Elsie, a widowed shop owner; Bert, a thief from Elsie's time; and Ted, a retired policeman. The final person, Sergeant Charlie Ellis, was a naval officer killed at the Battle of Trafalgar; his bundle contains only his uniform. These new people reveal that Jessica knew of the power of the key and the cupboard but only found out when she accidentally brought them to life for the first time. She brought them back and forth many times, just as Omri did with Little Bear. Just before she died, she told them all that they were being