Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard (film) one of their teachers tries to mediate, and when he realizes that an object in Patrick's fanny pack is the subject of contention, orders him to open it and show him. Boone and Little Bear pretend to be plastic toys thanks to Omri's hints and laying woodenly in Patrick's hand, successfully fool the teacher. Back home, Omri shows a female Indian figure to Little Bear, which he intends to bring to life to give Little Bear a new wife. Just as he is about to lock the figure in the cupboard, he and Patrick (who is spending the night) are