Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
The Heroic Age of American Invention The Heroic Age of American Invention The Heroic Age of American Invention is a 1961 science book for children by L. Sprague de Camp, published by Doubleday. It was reprinted in 1993 by Barnes & Noble under the title "Heroes of American Invention". By "heroic age" the author means the era of American history in which individual initiative and enterprise constituted the primary thread in technical innovation, roughly from the early 19th century until mass production and corporate enterprise outpaced that of the individual around the time of World War I. The story of innovation is told through the biographies