TARDIS 2005–10, the roundels are built into hexagonal recesses in the walls. Ever since the TARDIS was redesigned at the beginning of the 2010 series, there have been a range of different roundel designs around the console room. These include circular holes that are recessed deep into the walls, hexagonal holes that are lit from behind each face, round indents with brass rings around the outside, and a glass centre that is illuminated blue. In "The Day of the Doctor", when the TARDIS' control room briefly appears as the War Doctor's room, the Eleventh Doctor points out to the Tenth Doctor
Circular permutation in proteins a class of proteins involved in sphingolipid catabolism and antigen presentation of lipids in humans. Chris Ponting and Robert Russell identified a circularly permuted version of a saposin inserted into plant aspartic proteinase, which they nicknamed swaposin. Saposin and swaposin were the first known case of two natural genes related by a circular permutation. Hundreds of examples of protein pairs related by a circular permutation were subsequently discovered in nature or produced in the laboratory. As of February 2012, the Circular Permutation Database contains 2,238 circularly permuted protein pairs with known structures, and many more are known without structures. The