TARDIS by producer Barry Letts, who felt that the new roundels resembled washing-up bowls stuck to the wall. However, as fate would have it the set was damaged in storage between production blocks and had to be rebuilt, so this particular design only saw service in the one serial. The TARDIS has at least two console rooms: the primary one most used throughout the programme's history, and the secondary console room used during Season 14 in 1976/77, which has wood panelling and a more antique feel to it. It had been designed to make shooting more comfortable for the camera crew.
Circular permutation in proteins CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are currently being used to explain the evolution of circularly permuted proteins: "permutation by duplication" and "fission and fusion". The two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon