Map climatic features as the long-term mean values (of atmospheric pressure, temperature, humidity, total precipitation, and so forth) to connect points with equal values of the feature in question—for example, isobars for pressure, isotherms for temperature, and isohyets for precipitation. Isoamplitudes are drawn on maps of amplitudes (for example, annual amplitudes of air temperature—that is, the differences between the mean temperatures of the warmest and coldest month). Isanomals are drawn on maps of anomalies (for example, deviations of the mean temperature of each place from the mean temperature of the entire latitudinal zone). Isolines of frequency are drawn on maps showing
Atmospheric-pressure chemical ionization LC-MS had expanded dramatically the role of mass spectrometry in the pharmaceutical industry in the area of drug development. The sensitivity of APCI combined with the sensitivity and specificity of LC/MS and liquid chromatography-tandem mass spectrometry (LC-MS/MS) makes it the method of choice for the quantification of drugs and drug metabolites. Ionization of the substrate is very efficient as it occurs at atmospheric pressure, and thus has a high collision frequency. Additionally, APCI considerably reduces the thermal decomposition of the analyte because of the rapid desolvation and vaporization of the droplets in the initial stages of the ionization. This combination