Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard all to life with the cupboard to serve as Little Bear's army. They also buy plastic miniatures of modern guns to give to the Iroquois, as well as a miniature Royal Marine figurine (who turns out to be a British corporal named Fickits) to instruct the Iroquois in their use. After Little Bear and his troops are sent back, a casual comment by Boone prompts Omri and Patrick to wonder if it is the key which is magical, rather than the cupboard. Omri climbs into a large empty chest while holding Little Bear's plastic tipi and has Patrick turn the