Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard the French, and Boone wishes that he could somehow supply his friend with the "modern" six-shooters that are common in Boone's late 19th century timeline. Patrick gets the idea to take plastic soldiers (with 20th century weaponry) back through the cupboard to Little Bear's time. Little Bear likes the idea of modern weapons, but refuses to bring English soldiers back to his village. Omri is reluctant, believing this amounts to meddling with history, but is won over by his desire to save Little Bear's people. The boys buy several more plastic Iroquois figures from the local shops and bring them