Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard people in the far future, unable to return home without the key. They attempt to make a life with one another, eventually confessing their love. They are resigned to their fate, but long to return home and be properly married. Omri, by sheer luck, finds the key in the bushes and uses it to summon all of the group's friends for Boone and Ruby Lou's wedding before sending everyone home for what he promises will be the final time. Afterwards Omri asks his parents for a safe-deposit box, into which he puts the key, the cupboard, and a copy of