TARDIS were not, its weight would shatter the Earth's surface. In the tie-in novels, the interior of the TARDIS has been known to contain an entire city, encompass an entire parallel Earth, and even dwarf Gallifrey itself when turned inside out. A distinctive architectural feature of the TARDIS interior is the roundel. In the context of the TARDIS, a roundel is a circular decoration that adorns the walls of the rooms and corridors of the TARDIS, including the console room. Some roundels conceal TARDIS circuitry and devices, as seen in the serials "The Wheel in Space" (1968), "Logopolis", "Castrovalva" (1981), "Arc
Circular permutation in proteins CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are currently being used to explain the evolution of circularly permuted proteins: "permutation by duplication" and "fission and fusion". The two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon