The Birth of Venus adopted by Renaissance art historians in general, and it remains problematic, since it depends on the painting being commissioned by the Medici, yet the work is not documented in Medici hands until well into the following century. Mack sees the scene as inspired by both the Homeric Hymn and the ancient paintings. But something more than a rediscovered Homeric hymn was likely in the mind of the Medici family member who commissioned this painting from Botticelli. Once again, Botticelli, in his version of the Birth of Venus, might be seen as completing the task begun by his ancient predecessor Apelles,
The Birth of Venus of Florence, perhaps by Lorenzo di Pierfrancesco de' Medici (1463–1503) a major patron of Botticelli, under the influence of his cousin Lorenzo de' Medici, "il Magnifico". This was first suggested by Herbert Horne in his monograph of 1908, the first major modern work on Botticelli, and long followed by most writers, but more recently has been widely doubted, though it is still accepted by some. Various interpretations of the painting rely on this origin for its meaning. Although relations were perhaps always rather tense between the "Magnifico" and his young cousins and wards, Lorenzo di Pierfrancesco and his brother Giovanni