Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard meets Tom's daughter, who is wearing the long-lost earrings. Omri realizes that Jessica gave the earrings to Tom, who gave them to his daughter without knowing they were stolen. Having solved the mystery, he decides not to tell Tom's daughter the story of the earrings. Omri returns home to find that his father, while rebuilding Omri's bedroom, found the key, the cupboard, and the plastic figure of Little Bear and locked the toy in the cupboard, where he was shocked when Little Bear came to life. He has since been too frightened to open the cupboard while Little Bear called