Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard the cupboard without Omri's knowledge, bring to life the plastic cowboy, who turns out to be a man named Boone from an entirely different place and time as Little Bear. Over Omri's objections, Patrick introduces Boone to Little Bear. The two tiny men mistrust one another from the start, with Boone deriding Little Bear as "savage" and "dirty." The antagonism comes to a head when Omri and Patrick introduce the duo to television; when Boone cheers the slaughter of Native Americans in an old Western, Little Bear shoots him in the chest with an arrow. Little Bear is immediately guilty,