Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
Hepatitis B vaccine the vaccine still in use today. In 1976, Blumberg had won the Nobel Prize in Physiology or Medicine for his work on hepatitis B (sharing it with Daniel Carleton Gajdusek for his work on kuru). In 2002, Blumberg published a book, "Hepatitis B: The Hunt for a Killer Virus". In the book, according to Paul A. Offit—Hilleman's biographer and an accomplished vaccinologist himself—Blumberg... ... claimed that the hepatitis B vaccine was his invention. Maurice Hilleman's name is mentioned once... Blumberg failed to mention that it was Hilleman who had figured out how to inactivate hepatitis B virus, how to kill