Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Necessity is the mother of invention our invention." Jowett's translation is noted for injecting flowery, if not florid, language familiar to his Victorian era audience. Jowett himself, in "Plato's Republic: The Greek Text", Vol. III "Notes", 1894, p. 82, gives a literal translation of Plato as "our need will be the real creator," without the proverbial flourish. In an address to the Mathematical Association of England on the importance of education in 1917, Alfred North Whitehead argued that ""the basis of invention is science, and science is almost wholly the outgrowth of pleasurable intellectual curiosity."" and in contrast to the old proverb ""Necessity is the mother