Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard the cupboard without Omri's knowledge, bring to life the plastic cowboy, who turns out to be a man named Boone from an entirely different place and time as Little Bear. Over Omri's objections, Patrick introduces Boone to Little Bear. The two tiny men mistrust one another from the start, with Boone deriding Little Bear as "savage" and "dirty." The antagonism comes to a head when Omri and Patrick introduce the duo to television; when Boone cheers the slaughter of Native Americans in an old Western, Little Bear shoots him in the chest with an arrow. Little Bear is immediately guilty,