Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Sabin Willett Sabin Willett Peter Sabin Willett, known as Sabin Willett, (born March 6, 1957) is an American lawyer and novelist, a partner with the Philadelphia-based law firm Morgan, Lewis & Bockius, formerly a partner at Bingham McCutchen. He lives near Boston, Massachusetts. He is perhaps best known as a defense lawyer for several Uighur prisoners at the Guantanamo Bay detainment camp. Willett was educated in England at Gresham's School, Holt, and at Harvard College and Harvard Law School. As a lawyer, Willett concentrates his practice in commercial and bankruptcy litigation. He also represents a number of Uyghur captives in Guantanamo held