Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
For the Term of His Natural Life not stop treating him like an inferior, at one point upsetting Dawes so much that he considers leaving on his own. Only Sylvia's writing in the sand, "Good Mr. Dawes", stops him. Through a hazard, Frere tells Dawes of the fate of his cousin and how narrowly he missed inheriting the Devine fortune. Dawes had not known about Sir Richard's death. Finally, they set to sea with Mrs. Vickers gravely ill and Sylvia soon also sick. After some time they are found by an American vessel at which point Frere takes the rudder of the boat and Sylvia in his