Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard the cupboard without Omri's knowledge, bring to life the plastic cowboy, who turns out to be a man named Boone from an entirely different place and time as Little Bear. Over Omri's objections, Patrick introduces Boone to Little Bear. The two tiny men mistrust one another from the start, with Boone deriding Little Bear as "savage" and "dirty." The antagonism comes to a head when Omri and Patrick introduce the duo to television; when Boone cheers the slaughter of Native Americans in an old Western, Little Bear shoots him in the chest with an arrow. Little Bear is immediately guilty,