Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
John B. Robbins John B. Robbins John Bennett Robbins (born December 1, 1932) is a senior investigator at the National Institutes of Health, best known for his development of the vaccine against bacterial meningitis (Haemophilus influenzae type B (Hib)) with his colleague Rachel Schneerson. Bacterial meningitis is the leading cause of acquired mental retardation in children. Robbins is a recipient of the 1996 Albert Lasker Award for Clinical Medical Research, the Pasteur Award from the World Health Organization and the Albert B. Sabin Gold Medal in 2001 which he received for playing a major role in the development of Hib conjugate vaccine that