TARDIS 2005–10, the roundels are built into hexagonal recesses in the walls. Ever since the TARDIS was redesigned at the beginning of the 2010 series, there have been a range of different roundel designs around the console room. These include circular holes that are recessed deep into the walls, hexagonal holes that are lit from behind each face, round indents with brass rings around the outside, and a glass centre that is illuminated blue. In "The Day of the Doctor", when the TARDIS' control room briefly appears as the War Doctor's room, the Eleventh Doctor points out to the Tenth Doctor
Circular permutation in proteins CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are currently being used to explain the evolution of circularly permuted proteins: "permutation by duplication" and "fission and fusion". The two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon