Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
Alvah Sabin Alvah Sabin Alvah Sabin (October 23, 1793 – January 22, 1885) was an American politician and clergyman. He served as a United States Representative from Vermont. Sabin was born in Georgia, Vermont to Benjamin Sabin and Polly McMaster Sabin, and was educated in the common schools. He was also a member of the Vermont militia and served during the War of 1812. Sabin also attended the University of Vermont in Burlington, which awarded him the honorary degree of master of arts in 1826. After the war, Sabin studied theology in Philadelphia and graduated from Columbian College (now George Washington University),