Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
By His Bootstraps By His Bootstraps "By His Bootstraps" is a 20,000 word science fiction novella by American writer Robert A. Heinlein. It plays with some of the inherent paradoxes that would be caused by time travel. The story was published in the October 1941 issue of "Astounding Science Fiction" under the pen name Anson MacDonald; the same issue has "Common Sense" under Heinlein's name. "By His Bootstraps" was reprinted in Heinlein's 1959 collection "The Menace From Earth", and in several subsequent anthologies, and is now available in at least two audio editions. Under the title "The Time Gate", it was also included