Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard (film) one of their teachers tries to mediate, and when he realizes that an object in Patrick's fanny pack is the subject of contention, orders him to open it and show him. Boone and Little Bear pretend to be plastic toys thanks to Omri's hints and laying woodenly in Patrick's hand, successfully fool the teacher. Back home, Omri shows a female Indian figure to Little Bear, which he intends to bring to life to give Little Bear a new wife. Just as he is about to lock the figure in the cupboard, he and Patrick (who is spending the night) are