TARDIS to those first seen in 1963, with multiple roundels illuminated from behind. The fourth major redesign of the TARDIS in the revived series appeared in the eleventh series. New production designer Arwel Wyn Jones said that the inspiration for the Thirteenth Doctor's TARDIS was based on the 2005-10 model, which he had worked on. The console room is the "safest place on the ship," and so when its occupants are in danger the TARDIS will reinvent its architecture so as to allow them to enter the console room. This can also result in the TARDIS materialising itself within its own
Circular permutation in proteins CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are currently being used to explain the evolution of circularly permuted proteins: "permutation by duplication" and "fission and fusion". The two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon