Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
Arthur Knowles Sabin childhood toys, and Mary Greg. He remained in this post until 1940. He died in 1959. Sabin was also responsible for several catalogues at the Victoria and Albert and Bethnal Green Museums. Arthur Knowles Sabin Arthur Knowles Sabin (1879-1959), was a writer, poet and printer, best known for his development of the Bethnal Green Museum, now the Museum of Childhood, in London. Arthur K Sabin was born in Rotherham in 1879, the son of a Sheffield steel worker. He was largely self-educated. He married Elizabeth Thompson in 1903. He moved to Cranleigh, in Surrey. Here he wrote several poems, and