Wintergreen headache, fever, sore throat, and various aches and pains. These therapeutic effects likely arose because the primary metabolite of methyl salicylate is salicylic acid, a proven NSAID that is also the metabolite of acetylsalicylic acid, commonly known as aspirin. During the American Revolution, wintergreen leaves were used as a substitute for tea, which was scarce. Wintergreen is a common flavoring in American products ranging from chewing gum, mints, and candies to smokeless tobacco such as dipping tobacco (American "dip" snuff) and snus. It is a common flavoring for dental hygiene products such as mouthwash and toothpaste. It is a component
Shikimic acid is also an alternative to shikimic acid as a starting material for the synthesis of oseltamivir. Shikimate can be used to synthesise (6S)-6-Fluoroshikimic acid, an antibiotic which inhibits the aromatic biosynthetic pathway. Glyphosate, the active ingredient in the herbicide Roundup, kills plants by interfering with the shikimate pathway in plants. More specifically, glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). "Roundup Ready" genetically modified crops overcome that inhibition. Shikimic acid Shikimic acid, more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid. It is an important biochemical metabolite in plants and microorganisms. Its name