Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard turn out to be Elsie, a widowed shop owner; Bert, a thief from Elsie's time; and Ted, a retired policeman. The final person, Sergeant Charlie Ellis, was a naval officer killed at the Battle of Trafalgar; his bundle contains only his uniform. These new people reveal that Jessica knew of the power of the key and the cupboard but only found out when she accidentally brought them to life for the first time. She brought them back and forth many times, just as Omri did with Little Bear. Just before she died, she told them all that they were being