TARDIS tight schedule, which led to Brachacki leaving the show due to disagreements with the production team and possibly a feeling that he had been given an impossible task. Despite his leaving the show and mixed reactions as to how the set looked (producer Verity Lambert liked it but director Waris Hussein did not), the basic design of the hexagonal console and wall roundels has persisted to the present day. In the Third Doctor serial "The Time Monster" (1972), the console room of the TARDIS was dramatically altered, including the wall roundels. This new set, designed by Tim Gleeson, was disliked
Circular permutation in proteins CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are currently being used to explain the evolution of circularly permuted proteins: "permutation by duplication" and "fission and fusion". The two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon