Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard toys. He also possessed some of Jessica's magical abilities. Jessica had him create the cupboard, which he imbues with his hatred of plastic toys. This caused the cupboard to only bring plastic toys to life, which is why no other materials ever worked when Omri tried them in the cupboard. Omri meets one of the thatchers who worked on the roof when Jessica was dying, a man named Tom, and learns from him that Jessica let him in on the secret. She also gave him a little person to care for, a servant girl named Jenny from the 1800s who