Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard (film) fits the keyhole of his cupboard. He then looks for an object to lock in the cupboard and settles for the Indian figurine. The next morning, he hears a small tapping noise coming from the cupboard. Omri opens the cupboard and finds a small living person hiding in the corner. It is actually the Indian figure who has magically come to life in human form. Frightened by his large acquaintance, the Indian pulls out a dagger and points it at Omri. Shortly afterward, Omri's father comes in the room to help Omri get ready for school, forcing Omri to lock