Al Capp veterans returning from the war. Capp was also involved with the Sister Kenny Foundation, which pioneered new treatments for polio in the 1940s. Serving in his capacity as honorary chairman, Capp made public appearances on its behalf for years, contributed free artwork for its annual fund-raising appeals, and entertained crippled and paraplegic children in children's hospitals with inspirational pep talks, humorous stories and sketches. In 1940, an RKO movie adaptation starred Granville Owen (later known as Jeff York) as Li'l Abner, with Buster Keaton taking the role of Lonesome Polecat, and featuring a title song with lyrics by Milton Berle.
CAPP-Seq to quantify the previously identified mutations in the patient. CAPP-Seq can be applied to ctDNA from multiple blood samples at different time points in order to follow tumor evolution. A series of steps are involved in analysis of CAPP-Seq data from mutation detection to validation and open source software can do most of the analysis. After the first step of variant calling, germline and loss of heterozygosity (LOH) mutations are removed in CAPP-seq to reduce the background biases. Several statistical significance tests can be performed against background to all type of variant calling. For example, statistical significance of tumor-derived SNVs