Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
Medicine in the medieval Islamic world include "A Dissertation on the causes of the Coryza which occurs in the spring when roses give forth their scent", a tract in which al-Razi discussed why it is that one contracts coryza or common cold by smelling roses during the spring season, and "Bur’al Sa’a" ("Instant cure") in which he named medicines which instantly cured certain diseases. "Ibn Sina", more commonly known in west as Avicenna was a Persian polymath and physician of the tenth and eleventh centuries. He was known for his scientific works, but especially his writing on medicine. He has been described as the "Father of