Contour line factors in a weather system. An isobar (from or "baros", meaning 'weight') is a line of equal or constant pressure on a graph, plot, or map; an isopleth or contour line of pressure. More accurately, isobars are lines drawn on a map joining places of equal average atmospheric pressure reduced to sea level for a specified period of time. In meteorology, the barometric pressures shown are reduced to sea level, not the surface pressures at the map locations. The distribution of isobars is closely related to the magnitude and direction of the wind field, and can be used to predict
Atmospheric-pressure chemical ionization LC-MS had expanded dramatically the role of mass spectrometry in the pharmaceutical industry in the area of drug development. The sensitivity of APCI combined with the sensitivity and specificity of LC/MS and liquid chromatography-tandem mass spectrometry (LC-MS/MS) makes it the method of choice for the quantification of drugs and drug metabolites. Ionization of the substrate is very efficient as it occurs at atmospheric pressure, and thus has a high collision frequency. Additionally, APCI considerably reduces the thermal decomposition of the analyte because of the rapid desolvation and vaporization of the droplets in the initial stages of the ionization. This combination