TARDIS tight schedule, which led to Brachacki leaving the show due to disagreements with the production team and possibly a feeling that he had been given an impossible task. Despite his leaving the show and mixed reactions as to how the set looked (producer Verity Lambert liked it but director Waris Hussein did not), the basic design of the hexagonal console and wall roundels has persisted to the present day. In the Third Doctor serial "The Time Monster" (1972), the console room of the TARDIS was dramatically altered, including the wall roundels. This new set, designed by Tim Gleeson, was disliked
Circular permutation in proteins a class of proteins involved in sphingolipid catabolism and antigen presentation of lipids in humans. Chris Ponting and Robert Russell identified a circularly permuted version of a saposin inserted into plant aspartic proteinase, which they nicknamed swaposin. Saposin and swaposin were the first known case of two natural genes related by a circular permutation. Hundreds of examples of protein pairs related by a circular permutation were subsequently discovered in nature or produced in the laboratory. As of February 2012, the Circular Permutation Database contains 2,238 circularly permuted protein pairs with known structures, and many more are known without structures. The