Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
The Man Who Mistook His Wife for a Hat (opera) the piano, the actor actually playing if possible. The plot concerns the investigation by a neurologist of the condition of a singer who suffers from visual agnosia. According to the liner notes, Morris, Rawlence, and Nyman had to spend much time convincing the real Mrs. P. (whose husband is implied to have been a known name) that they were not proposing a musical (her word) that would trivialize her late husband's situation in order to gain her consent. Rawlence made a film version in 1987. It made brief omissions from the music (most notably the self-referential line, "That's Nyman! Can't