Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Cold War tensions and the polio vaccine flew to Leningrad in June, 1956. As a result of a cooperation of Sabin and Chumakov in Leningrad, Sabin was able to test his attenuated vaccine when funding in America was declined. While Sabin was working behind the Iron Curtain, the Sabin-Chumakov vaccine was determined to be safe and effective. Cold War tensions caused Western scientists to refuse the reports from the Russians about the effectiveness of the Sabin vaccine. However, mass vaccinations of Sabin's vaccine spread throughout Eastern Europe from 1960–1963. Just as some Soviet virologists did not trust the Western Salk vaccine, Americans had similar reservations about the