The Claws of Axos standard. The story includes interior scenes inside the TARDIS for the first time in the Pertwee era of the show. The configuration of the TARDIS set-up is unique for this adventure. The TARDIS monitor appears to be a circular screen embedded in one of the 'roundels' in the console room wall, rather than the traditional rectangular screen (this feature is seen again once, a year later, on the unique set built for "The Time Monster"). The doors of the console room do not open directly into the exterior as in all other adventures; instead they open into a corridor that
Circular permutation in proteins CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are currently being used to explain the evolution of circularly permuted proteins: "permutation by duplication" and "fission and fusion". The two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon