Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
Cupboard Cupboard The term cupboard was originally used to describe an open-shelved side table for displaying dishware, more specifically plates, cups and saucers. These open cupboards typically had between one and three display tiers, and at the time, a drawer or multiple drawers fitted to them. The word cupboard gradually came to mean a closed piece of furniture. The word cupboard is also frequently used in British English to denote what North Americans would call a closet. An airing cupboard is a storage space, sometimes of walk-in dimensions, containing a water heater; either an immersion heater for hot running water or