Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard (film) Bear tells Omri to send the man back, but Omri is reluctant, worried that no one will find his body if he was alone when Omri summoned him. Little Bear yells at Omri, saying that he, Little Bear, had been guiding his nephew through the woods to teach him how to be a man when Omri had taken him away and that Omri shouldn't tamper with magic he doesn't even understand. This upsets Omri. Omri locks the dead Chieftain in the cupboard, making him plastic once more, before leaving the angry Little Bear to answer his dad calling him downstairs.