Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard the plastic figurine in the cupboard and locks it with the key, only to discover the following morning that the figurine has come to life as a three-inch tall Iroquois man. After a bewildering first encounter, Omri hastily locks the man back into the cupboard to prevent his discovery while Omri is away at school, only to be crestfallen when he returns home to find the man returned to lifeless plastic. Curious, Omri relocks the figurine in the cupboard and it comes to life once more. Though the tiny man, whose name is Little Bear (Little Bull in some editions),