Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Indian in the Cupboard (film) puzzled to find the cupboard is missing. Omri's brother confesses he hid the cupboard in the downstairs crawlspace as means of getting back at Omri for hiding the ball his brother keeps his pet rat in. When Omri retrieves the cupboard, he discovers that the key is gone. That night, Omri and Patrick, along with Little Bear and Boone, watch a program on TV that shows a relentless slaughter of Indians by cowboys. Boone is enthusiastic at the sight of his "boys" killing the helpless Indians, while Little Bear watches in horror at the sight of his "people" being massacred.