Varicella vaccine given subcutaneously (under the skin). It is recommended for all children under 13 and for everyone 13 or older who has never had chickenpox. In the United States two doses are recommended. In the first case a first dose is administered at 12 to 15 months and a second dose at age 4–6 years. For people older than 13 the two doses are administered 4 to 8 weeks apart. The varicella vaccine did not become widely available in the United States until 1995. In the UK, the vaccine is only recommended in people who are particularly vulnerable to chickenpox. The
Paget's disease of bone involve an inflammatory process, which is implied by the suffix "-itis". Now, that term is considered technically incorrect, and the preferred term is osteodystrophia deformans. Paget's disease of bone Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation. These structural changes cause the bone to weaken, which may result in deformity, pain, fracture, or arthritis of associated joints. The exact