Varicella (video game) despicable antagonists (just as variola is more virulent than varicella), thus making players willing to go along with his schemes. The international situation in the game is described in passing: Piedmont is part of a loose confederation of kingdoms that make up a Carolingian League and is engaged in a war against the Republic of Venice. It won four XYZZY Awards in 1999 including the XYZZY Award for Best Game, and was nominated for another four. The game was discussed academically by Nick Montfort and Stuart Moulthrop in their 2003 paper "Face It, Tiger, You Just Hit the Jackpot: Reading
Rare disease treated, are excluded from their definition. The definitions used in the medical literature and by national health plans are similarly divided, with definitions ranging from 1/1,000 to 1/200,000. Because of definitions that include reference to treatment availability, a lack of resources, and severity of the disease, the term "orphan disease" is used as a synonym for "rare disease". But in the United States and the European Union, "orphan diseases" have a distinct legal meaning. The United States' Orphan Drug Act includes both rare diseases and any non-rare diseases "for which there is no reasonable expectation that the cost of developing