Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Albert Joyce Riker a retired microbiologist from the University of Arizona. He died in Tucson, Arizona. Albert Joyce Riker Dr. Albert Joyce Riker (April 3, 1894 – February 21, 1982) was a noted American plant pathologist and professor at the University of Wisconsin–Madison. Riker was born in Wheeling, West Virginia, the son of Albert Birdsall and Mary Edith (Davis) Riker. He graduated from high school in Moundsville, West Virginia, after which he worked for the Royal Three Barrel Gun Company, was an automobile repairman and salesman, and helped build greenhouses. He then attended Oberlin College, receiving in 1917 his A.B. degree in botany.