TARDIS console rooms, in any of the known configurations, is the TARDIS console that holds the instruments that control the ship's functions. The appearance of the primary TARDIS consoles has varied widely but shares common details: hexagonal pedestals with controls around the periphery, and a moveable column (or time rotor as it has been called in the original series and the 2011 episode "The Doctor's Wife") in the centre that bobs rhythmically up and down when the TARDIS is in flight, like a pump or a piston. The secondary console was first seen in season 14 (1976–77) of the original series.
Circular permutation in proteins a class of proteins involved in sphingolipid catabolism and antigen presentation of lipids in humans. Chris Ponting and Robert Russell identified a circularly permuted version of a saposin inserted into plant aspartic proteinase, which they nicknamed swaposin. Saposin and swaposin were the first known case of two natural genes related by a circular permutation. Hundreds of examples of protein pairs related by a circular permutation were subsequently discovered in nature or produced in the laboratory. As of February 2012, the Circular Permutation Database contains 2,238 circularly permuted protein pairs with known structures, and many more are known without structures. The