Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard book, Omri receives wins first prize in a story-writing competition for his tale "The Plastic Indian," which is actually a recounting of his real adventures with the cupboard; everyone else assumes that Omri's story is fictional. Wanting to share his good news, Omri brings Little Bear and Bright Stars through the magic cupboard. Little Bear returns badly injured by the French soldiers he has been fighting in his own time. Omri attempts to bring back Tommy, the WWI field medic from the first book, but receives only Tommy's neatly folded uniform and medical bag, causing him to realized that Tommy