TARDIS by producer Barry Letts, who felt that the new roundels resembled washing-up bowls stuck to the wall. However, as fate would have it the set was damaged in storage between production blocks and had to be rebuilt, so this particular design only saw service in the one serial. The TARDIS has at least two console rooms: the primary one most used throughout the programme's history, and the secondary console room used during Season 14 in 1976/77, which has wood panelling and a more antique feel to it. It had been designed to make shooting more comfortable for the camera crew.
Circular permutation in proteins a class of proteins involved in sphingolipid catabolism and antigen presentation of lipids in humans. Chris Ponting and Robert Russell identified a circularly permuted version of a saposin inserted into plant aspartic proteinase, which they nicknamed swaposin. Saposin and swaposin were the first known case of two natural genes related by a circular permutation. Hundreds of examples of protein pairs related by a circular permutation were subsequently discovered in nature or produced in the laboratory. As of February 2012, the Circular Permutation Database contains 2,238 circularly permuted protein pairs with known structures, and many more are known without structures. The