TARDIS console rooms, in any of the known configurations, is the TARDIS console that holds the instruments that control the ship's functions. The appearance of the primary TARDIS consoles has varied widely but shares common details: hexagonal pedestals with controls around the periphery, and a moveable column (or time rotor as it has been called in the original series and the 2011 episode "The Doctor's Wife") in the centre that bobs rhythmically up and down when the TARDIS is in flight, like a pump or a piston. The secondary console was first seen in season 14 (1976–77) of the original series.
Circular permutation in proteins CyBase database collects proteins that are cyclic, some of which are permuted variants of cyclic wild-type proteins. SISYPHUS is a database that contains a collection of hand-curated manual alignments of proteins with non-trivial relationships, several of which have circular permutations. There are two main models that are currently being used to explain the evolution of circularly permuted proteins: "permutation by duplication" and "fission and fusion". The two models have compelling examples supporting them, but the relative contribution of each model in evolution is still under debate. Other, less common, mechanisms have been proposed, such as "cut and paste" or "exon