Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
The Skeleton in the Cupboard (Yes Minister) has to hand a list of the standard government reasons for exempting information from the 30-year rule: it covers every document in the file. The Skeleton in the Cupboard (Yes Minister) "The Skeleton in the Cupboard" is the seventeenth episode of the BBC comedy series "Yes Minister" and was first broadcast 25 November 1982. Jim Hacker is chairing a meeting with his senior officials. One item on the agenda is the disciplinary action to be taken against the South Derbyshire local authority for failing to complete its statutory returns and supply required information. Sir Humphrey Appleby regards this as a