Earl of Salisbury later by Richard Neville "the Kingmaker", upon whose death the title went into abeyance because multiple individuals were entitled to inherit it. Then, in 1472, it was granted to George, Duke of Clarence, who was married to Warwick's eldest daughter. When the Duke of Clarence was executed in 1478 for treason (supposedly by being drowned in a vat of Malmsey wine), the title was forfeit. It was then granted to Edward of Middleham (who was his nephew via the Duke's brother Richard), who died in 1484 at the age of 11. It was restored to two of George of Clarence's
Isabel Neville, Duchess of Clarence to England's heir presumptive, George Plantagenet, 1st Duke of Clarence, the brother of both King Edward IV and Richard, Duke of Gloucester (later Richard III). The king opposed the marriage as it would bring the already powerful Earl of Warwick too close to the throne. However the ceremony took place in secret at Calais on 11 July 1469, conducted by Isabel Neville's uncle George Neville, archbishop of York. Following their marriage Clarence joined forces with Warwick and allied with the Lancastrians led by Margaret of Anjou, queen consort to Henry VI. After Isabel Neville's sister Anne was married to Edward