Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard people in the far future, unable to return home without the key. They attempt to make a life with one another, eventually confessing their love. They are resigned to their fate, but long to return home and be properly married. Omri, by sheer luck, finds the key in the bushes and uses it to summon all of the group's friends for Boone and Ruby Lou's wedding before sending everyone home for what he promises will be the final time. Afterwards Omri asks his parents for a safe-deposit box, into which he puts the key, the cupboard, and a copy of