Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
Albert Joyce Riker a retired microbiologist from the University of Arizona. He died in Tucson, Arizona. Albert Joyce Riker Dr. Albert Joyce Riker (April 3, 1894 – February 21, 1982) was a noted American plant pathologist and professor at the University of Wisconsin–Madison. Riker was born in Wheeling, West Virginia, the son of Albert Birdsall and Mary Edith (Davis) Riker. He graduated from high school in Moundsville, West Virginia, after which he worked for the Royal Three Barrel Gun Company, was an automobile repairman and salesman, and helped build greenhouses. He then attended Oberlin College, receiving in 1917 his A.B. degree in botany.