Mikhail Chumakov founded was renamed in his honor as of the Russian Academy of Medical Sciences. In 2016 the Institute and its vaccine manufacturing facility were reorganized into M.P. Chumakov Center for Research and Development of Biological Products of the Russian Academy of Sciences. A main-belt asteroid 5465 Chumakov discovered by Lyudmila Georgievna Karachkina was also named in his honor. Mikhail Chumakov Mikhail Petrovich Chumakov () (November 14, 1909 – June 11, 1993) was a Soviet microbiologist and virologist most famous for conducting pivotal large-scale clinical trials that led to licensing of the Oral Polio Vaccine (OPV) developed by Albert B. Sabin.
Polio vaccine attenuate the Sabin 2 strain, and 10 substitutions are involved in attenuating the Sabin 3 strain. The primary attenuating factor common to all three Sabin vaccines is a mutation located in the virus's internal ribosome entry site, which alters stem-loop structures, and reduces the ability of poliovirus to translate its RNA template within the host cell. The attenuated poliovirus in the Sabin vaccine replicates very efficiently in the gut, the primary site of infection and replication, but is unable to replicate efficiently within nervous system tissue. In 1961, type 1 and 2 monovalent oral poliovirus vaccine (MOPV) was licensed, and