Polio vaccine polio and post-polio syndrome. In the United States, vaccine is administered along with the tetanus, diphtheria, and acellular pertussis vaccines (DTaP) and a pediatric dose of hepatitis B vaccine. In the UK, IPV is combined with tetanus, diphtheria, pertussis, and "Haemophilus influenzae" type b vaccines. OPV is an attenuated vaccine, produced by the passage of the virus through nonhuman cells at a subphysiological temperature, which produces spontaneous mutations in the viral genome. Oral polio vaccines were developed by several groups, one of which was led by Albert Sabin. Other groups, led by Hilary Koprowski and H.R. Cox, developed their own
David Bruce (microbiologist) David Bruce (microbiologist) Major-General Sir David Bruce (29 May 1855 in Melbourne – 27 November 1931 in London) was a Scottish pathologist and microbiologist who investigated Malta fever (later called brucellosis in his honour) and African trypanosomiasis (sleeping sickness in humans and nagana in animals). He discovered a protozoan parasite transmitted by insects, later named "Trypanosoma brucei" after him. Working in the Army Medical Service and the Royal Army Medical Corps, his major scientific collaborator was his microbiologist wife Mary Elizabeth Bruce ("née" Steele), with whom he published more than thirty technical papers. Bruce was born in Melbourne, Australia to