Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
Chlorosulfuric acid cyclized with ammonia and neutralized with base to afford saccharin. Chlorosulphonic acid has been used as an anti-contrail agent in Ryan Model 147 reconnaissance drones, and to produce smoke screens. ClSOH reacts violently with water to yield sulfuric acid and hydrogen chloride, commonly seen as vapors fuming from the liquid. Precautions, such as proper ventilation, associated with HCl should be observed. Chlorosulfuric acid Chlorosulfuric acid (IUPAC name: sulfurochloridic acid) is the inorganic compound with the formula HSOCl. It is also known as chlorosulfonic acid, being the sulfonic acid of chlorine. It is a distillable, colorless liquid which is hygroscopic and