Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
Samuel Katz (pediatrician) the Albert B. Sabin Gold Medal awarded by the Sabin Vaccine Institute for his contributions to vaccine discoveries during his career. Samuel Katz (pediatrician) Samuel L. Katz (born 1927) is an American pediatrician and virologist whose career has been devoted to infectious disease research, focusing principally on vaccine research and development. Katz is currently the Wilburt Cornell Davison Professor and Chairman Emeritus of Pediatrics at Duke University. October 15, 1958 the first Measles Vaccine is tested in a Boston lab. The first version of the lab’s vaccine on mentally retarded and disabled children at a school outside of Boston. He