Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
What Time Is Love? original "What Time Is Love?" was covered by the Williams Fairey Band, a brass band which under the stewardship of British artist Jeremy Deller pioneered the Acid Brass concept. Inspired by an Acid Brass concert, Drummond and Cauty collaborated with Deller, incorporating an Acid Brass version of "What Time Is Love?" into their single "Fuck the Millennium". The original 1988 12" single release launched The KLF's minimalist "Pure Trance" series of singles. The "Pure Trance" version is a synthesiser composition based around an acid house riff on three low-pitched notes and one minor chord (B minor). The subtle progression of