Polio vaccine polio and post-polio syndrome. In the United States, vaccine is administered along with the tetanus, diphtheria, and acellular pertussis vaccines (DTaP) and a pediatric dose of hepatitis B vaccine. In the UK, IPV is combined with tetanus, diphtheria, pertussis, and "Haemophilus influenzae" type b vaccines. OPV is an attenuated vaccine, produced by the passage of the virus through nonhuman cells at a subphysiological temperature, which produces spontaneous mutations in the viral genome. Oral polio vaccines were developed by several groups, one of which was led by Albert Sabin. Other groups, led by Hilary Koprowski and H.R. Cox, developed their own
Sabin Vaccine Institute Development, the Global Network for Neglected Tropical Diseases, and Vaccine Advocacy and Education. Through its Product Development Partnership (PDP), Sabin has worked with organizations such as King Saud University, Texas Children's Hospital Center, International Vaccine Institute, and George Washington University School of Medicine & Health Sciences toward its goals, with funding and support from the Bill & Melinda Gates Foundation, the National Institute of Allergy and Infectious Diseases, the Dutch Ministry of Foreign Affairs, the Brazilian Ministry of Health and other benefactors. In 2012, Sabin partnered with International Vaccine Institute to combine their research, development, and promotion efforts in Asia,