Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard meets Tom's daughter, who is wearing the long-lost earrings. Omri realizes that Jessica gave the earrings to Tom, who gave them to his daughter without knowing they were stolen. Having solved the mystery, he decides not to tell Tom's daughter the story of the earrings. Omri returns home to find that his father, while rebuilding Omri's bedroom, found the key, the cupboard, and the plastic figure of Little Bear and locked the toy in the cupboard, where he was shocked when Little Bear came to life. He has since been too frightened to open the cupboard while Little Bear called