Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard the plastic figurine in the cupboard and locks it with the key, only to discover the following morning that the figurine has come to life as a three-inch tall Iroquois man. After a bewildering first encounter, Omri hastily locks the man back into the cupboard to prevent his discovery while Omri is away at school, only to be crestfallen when he returns home to find the man returned to lifeless plastic. Curious, Omri relocks the figurine in the cupboard and it comes to life once more. Though the tiny man, whose name is Little Bear (Little Bull in some editions),