Andy Capp the comic attempting to find a gas leak in three frames of the 18 June 1960 strip. He was also shown in two drawn photographs in the 2 July 1960 issue, the first of which was displayed by Buster's mum with the pronouncement "It's a photo of Buster taken with Andy! You can see he's got his dad's fine straight nose". Buster's mum was often referred to by name and was consistently drawn to resemble Andy's wife Flo. Andy Capp Andy Capp is an English comic strip created by cartoonist Reg Smythe, seen in "The Daily Mirror" and "The Sunday
CAPP-Seq to quantify the previously identified mutations in the patient. CAPP-Seq can be applied to ctDNA from multiple blood samples at different time points in order to follow tumor evolution. A series of steps are involved in analysis of CAPP-Seq data from mutation detection to validation and open source software can do most of the analysis. After the first step of variant calling, germline and loss of heterozygosity (LOH) mutations are removed in CAPP-seq to reduce the background biases. Several statistical significance tests can be performed against background to all type of variant calling. For example, statistical significance of tumor-derived SNVs