Polio vaccine polio and post-polio syndrome. In the United States, vaccine is administered along with the tetanus, diphtheria, and acellular pertussis vaccines (DTaP) and a pediatric dose of hepatitis B vaccine. In the UK, IPV is combined with tetanus, diphtheria, pertussis, and "Haemophilus influenzae" type b vaccines. OPV is an attenuated vaccine, produced by the passage of the virus through nonhuman cells at a subphysiological temperature, which produces spontaneous mutations in the viral genome. Oral polio vaccines were developed by several groups, one of which was led by Albert Sabin. Other groups, led by Hilary Koprowski and H.R. Cox, developed their own
Albert Sabin in the U.S. Army Medical Corps and helped develop a vaccine against Japanese encephalitis. Maintaining his association with Children's Hospital, by 1946, he had also become the head of Pediatric Research at the University of Cincinnati. At Cincinnati's Children's Hospital, Sabin supervised the fellowship of Robert M. Chanock, whom he called his "star scientific son." Sabin went on a fact-finding trip to Cuba in 1967 to discuss with Cuban officials the possibility of establishing a collaborative relationship between the United States and Cuba through their respective national academies of sciences, in spite of the fact that the two countries did