Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Alvah Sabin Alvah Sabin Alvah Sabin (October 23, 1793 – January 22, 1885) was an American politician and clergyman. He served as a United States Representative from Vermont. Sabin was born in Georgia, Vermont to Benjamin Sabin and Polly McMaster Sabin, and was educated in the common schools. He was also a member of the Vermont militia and served during the War of 1812. Sabin also attended the University of Vermont in Burlington, which awarded him the honorary degree of master of arts in 1826. After the war, Sabin studied theology in Philadelphia and graduated from Columbian College (now George Washington University),