Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard tiny figures and awareness that, though small, they were real people who ought not to be so manipulated." Despite the wide range of views on this novel, little information exists about any challenges the author faced in publishing it. At one time classrooms and libraries widely accepted the book. On Omri’s ninth birthday, his best friend Patrick gives Omri the disappointing gift of a small plastic Indian figurine. Omri also receives a white metal medicine cupboard from his brother. The only key in the house that fits the cupboard's lock is the key to Omri's great-grandmother's jewelry box. Omri puts