Varicella (video game) and Playing Cadre's Varicella", and by Dr. Wendy Morgan in her 2003 paper "Touching (on) Character: New Engagements in New Media Narratives". Cadre himself claimed in a January 2002 interview that it was the best game he had written up to that point: Varicella (video game) Varicella is a 1999 work of interactive fiction by Adam Cadre, distributed in z-code format as freeware. It is set in an alternate history which features roughly modern technology mixed with Renaissance-style principalities and court politics. The characters of Varicella use contemporary language from their home in a Renaissance castle, continuing the contrast between
Rare disease treated, are excluded from their definition. The definitions used in the medical literature and by national health plans are similarly divided, with definitions ranging from 1/1,000 to 1/200,000. Because of definitions that include reference to treatment availability, a lack of resources, and severity of the disease, the term "orphan disease" is used as a synonym for "rare disease". But in the United States and the European Union, "orphan diseases" have a distinct legal meaning. The United States' Orphan Drug Act includes both rare diseases and any non-rare diseases "for which there is no reasonable expectation that the cost of developing