Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
What? Where? When? Russia and Azerbaijan. The 2010 championship took place in Israel with sponsorship of Euro-Asian Jewish Congress. These competitions rely on logic rather than knowledge too, but usually require more erudition than the TV versions due to high educational level of gamers. What? Where? When? What? Where? When? (, translit. "Chto? Gde? Kogda?") is an intellectual game show well known in Russian-language media and other CIS states since the mid-1970s. Today it is produced for television by TV Igra on the Russian Channel One and also exists as a competitive game played in clubs organized by the World Association of Clubs.