Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
What? Where? When? Russia and Azerbaijan. The 2010 championship took place in Israel with sponsorship of Euro-Asian Jewish Congress. These competitions rely on logic rather than knowledge too, but usually require more erudition than the TV versions due to high educational level of gamers. What? Where? When? What? Where? When? (, translit. "Chto? Gde? Kogda?") is an intellectual game show well known in Russian-language media and other CIS states since the mid-1970s. Today it is produced for television by TV Igra on the Russian Channel One and also exists as a competitive game played in clubs organized by the World Association of Clubs.