Polio vaccine attenuated vaccine strains. In 1958, the National Institutes of Health created a special committee on live polio vaccines. The various vaccines were carefully evaluated for their ability to induce immunity to polio, while retaining a low incidence of neuropathogenicity in monkeys. Large-scale clinical trials performed in the Soviet Union in late 1950s to early 1960s by Mikhail Chumakov and his colleagues demonstrated safety and high efficacy of the vaccine. Based on these results, the Sabin strains were chosen for worldwide distribution. Fifty-seven nucleotide substitutions distinguish the attenuated Sabin 1 strain from its virulent parent (the Mahoney serotype), two nucleotide substitutions
His Majesty, the American His Majesty, the American His Majesty, the American is a 1919 American comedy film directed by Joseph Henabery and starring Douglas Fairbanks. It was the first film released by United Artists. Several copies of the film exist in archives and collections. As described in a film magazine, Bill (Fairbanks), whose hair raising antics have made him the talk of New York City, decides to leave the metropolis after a new district attorney starts cracking down on minor offenses, and visits Mexico in search of adventure. He receives a telegram for a foreign country asking him to come at once to