Vaccine one of the vaccine components is more robust than the others and suppresses the growth and immune response to the other components. This phenomenon was first noted in the trivalent Sabin polio vaccine, where the amount of serotype 2 virus in the vaccine had to be reduced to stop it from interfering with the "take" of the serotype 1 and 3 viruses in the vaccine. This phenomenon has also been found to be a problem with the dengue vaccines currently being researched, where the DEN-3 serotype was found to predominate and suppress the response to DEN-1, −2 and −4 serotypes.
Sabin of Bulgaria Pagan, but the emperor's words on behalf of the former monarch made little impression. Sabin passed the remainder of his life in exile. Sabin of Bulgaria Sabin () was the ruler of Bulgaria from 765 to 766. Some scholars think that Sabin was omitted from the Namelist of Bulgarian Rulers because he was a Slav, but his name could indicate Latin or even Iranian origins. He was related by marriage to Kormisosh, who was either a father-in-law or a brother-in-law of Sabin. Since the relation is by marriage, Sabin would not have actually belonged to the Vokil (=Ukil?) clan. Sabin