Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
The Indian in the Cupboard (film) Bear tells Omri to send the man back, but Omri is reluctant, worried that no one will find his body if he was alone when Omri summoned him. Little Bear yells at Omri, saying that he, Little Bear, had been guiding his nephew through the woods to teach him how to be a man when Omri had taken him away and that Omri shouldn't tamper with magic he doesn't even understand. This upsets Omri. Omri locks the dead Chieftain in the cupboard, making him plastic once more, before leaving the angry Little Bear to answer his dad calling him downstairs.