Aspirin for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next fifty years, other chemists established the chemical structure and came up with more efficient methods to make it. In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the twentieth century leading to competition between
The Indian in the Cupboard the French, and Boone wishes that he could somehow supply his friend with the "modern" six-shooters that are common in Boone's late 19th century timeline. Patrick gets the idea to take plastic soldiers (with 20th century weaponry) back through the cupboard to Little Bear's time. Little Bear likes the idea of modern weapons, but refuses to bring English soldiers back to his village. Omri is reluctant, believing this amounts to meddling with history, but is won over by his desire to save Little Bear's people. The boys buy several more plastic Iroquois figures from the local shops and bring them