Barometer Simultaneous barometric readings from across a network of weather stations allow maps of air pressure to be produced, which were the first form of the modern weather map when created in the 19th century. Isobars, lines of equal pressure, when drawn on such a map, give a contour map showing areas of high and low pressure. Localized high atmospheric pressure acts as a barrier to approaching weather systems, diverting their course. Atmospheric lift caused by low-level wind convergence into the surface brings clouds and sometimes precipitation. The larger the change in pressure, especially if more than 3.5 hPa (0.1 inHg),
Atmospheric-pressure chemical ionization LC-MS had expanded dramatically the role of mass spectrometry in the pharmaceutical industry in the area of drug development. The sensitivity of APCI combined with the sensitivity and specificity of LC/MS and liquid chromatography-tandem mass spectrometry (LC-MS/MS) makes it the method of choice for the quantification of drugs and drug metabolites. Ionization of the substrate is very efficient as it occurs at atmospheric pressure, and thus has a high collision frequency. Additionally, APCI considerably reduces the thermal decomposition of the analyte because of the rapid desolvation and vaporization of the droplets in the initial stages of the ionization. This combination