Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective the end of the word, as in Latin: In Celtic languages, however, initial consonant lenition marks the adjective with a feminine singular noun, as in Irish: Often, distinction is made here between attributive and predicative usage. In English, adjectives never agree, and in French, they always agree. In German, they agree only when they are used attributively, and in Hungarian, they agree only when they are used predicatively: Adjective In linguistics, an adjective (abbreviated ) is a describing word, the main syntactic role of which is to qualify a noun or noun phrase, giving more information about the object signified.