Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective phrase An attributive adjective (phrase) precedes the noun of a noun phrase (e.g. "a very happy" man). A predicative adjective (phrase) follows a linking verb and serves to describe the preceding subject, e.g. "The man is very happy". The adjective phrases are underlined in the following example sentences. The head adjective in each of these phrases is in bold, and how the adjective phrase is functioning—attributively or predicatively—is stated to the right of each example: The distinguishing characteristic of an attributive adjective phrase is that it appears inside the noun phrase that it modifies. An interesting trait of these phrases in