Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective phrase Adjective phrase An adjective phrase (or adjectival phrase) is a phrase the head word of which is an adjective, e.g. "fond of steak", "very happy", "quite upset about it", etc. The adjective can initiate the phrase (e.g. "fond of steak"), conclude the phrase (e.g. "very happy"), or appear in a medial position (e.g. "quite upset about it"). The dependents of the head adjective—i.e. the other words and phrases inside the adjective phrase—are typically adverb or prepositional phrases, but they can also be clauses (e.g. "louder than you are"). Adjectives and adjective phrases function in two basic ways, attributively or predicatively.