Hepatic arterial infusion proper and common hepatic arteries, and threaded through the gastroduodenal (mostly), or celiac artery. The catheter is fixed in this position and the pump is placed in a subcutaneous pocket. Finally, to confirm adequate placement and hepatic perfusion, and to rule out extrahepatic perfusion, a dye (fluorescein or methylene blue) is injected into the pump. After the procedure and before starting the HAI based treatment, a technetium 99m-labeled macroaggregated albumin scan is performed to again confirm adequate hepatic perfusion and no misperfusion outside of the liver. The complications of HAI therapy can be divided into those related to the surgical
Organ-on-a-chip models that replicate aspects of the human body as closely as possible and give examples that demonstrate their potential use in drug development, such as identifying synergistic drug interactions as well as simulating multi-organ metabolic interactions. Multi compartment micro fluidic-based devices, particularly those that are physical representations of physiologically based pharmacokinetic (PBPK) models that represent the mass transfer of compounds in compartmental models of the mammalian body, may contribute to improving the drug development process. Mathematical pharmacokinetic (PK) models aim to estimate concentration-time profiles within each organ on the basis of the initial drug dose. Such mathematical models can be