Hepatic veins ultimately from numerous central veins of the liver lobules. None of the hepatic veins have valves. The hepatic veins are divided into an upper and a lower group. The upper three drain the central veins from the right, middle, and left regions of the liver and are larger than the lower group of veins. The lower group of from six to twenty smaller hepatic veins come from the right lobe and the caudate lobe, are in contact with the hepatic tissue, and are valveless. All the veins empty into the inferior vena cava at the back of the liver. Budd–Chiari
Organ-on-a-chip models that replicate aspects of the human body as closely as possible and give examples that demonstrate their potential use in drug development, such as identifying synergistic drug interactions as well as simulating multi-organ metabolic interactions. Multi compartment micro fluidic-based devices, particularly those that are physical representations of physiologically based pharmacokinetic (PBPK) models that represent the mass transfer of compounds in compartmental models of the mammalian body, may contribute to improving the drug development process. Mathematical pharmacokinetic (PK) models aim to estimate concentration-time profiles within each organ on the basis of the initial drug dose. Such mathematical models can be