Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective phrase English is that an attributive adjective alone generally precedes the noun, e.g. "a proud man", whereas a head-initial or head-medial adjective phrase follows its noun, e.g. "a man proud of his children". A predicative adjective (phrase), in contrast, appears outside of the noun phrase that it describes, usually after a linking verb, e.g. "The man is proud of his children". There is a tendency to call a phrase an "adjectival phrase" when that phrase is functioning like an adjective phrase, but is not actually headed by an adjective. For example, in "Mr Clinton is a man of wealth", the prepositional