Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective Adjective In linguistics, an adjective (abbreviated ) is a describing word, the main syntactic role of which is to qualify a noun or noun phrase, giving more information about the object signified. Adjectives are one of the English parts of speech, although they were historically classed together with the nouns. Certain words that were traditionally considered to be adjectives, including "the", "this", "my", etc., are today usually classed separately, as determiners. "Adjective" comes from Latin "" "additional (noun)", a calque of . In the grammatical tradition of Latin and Greek, because adjectives were inflected for gender, number, and case like