Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Nominalized adjective "headwind" is then assumed. The third type is known as the "permanent" adjectival noun and has an adjective that stands alone as a noun. Such adjectives have become nouns over time, and most speakers are aware of their implicit adjectival meaning. Nominalized adjectives occur frequently in both Classical Arabic and Modern Standard Arabic. An example would be "things (that are) Islamic", which is derived from the adjective "Islamic" in the inanimate plural inflection. Another example would be "the big one" (said of a person or thing of masculine gender), from "big" inflected in the masculine singular. Nominalized adjective A nominalized