Hepatic arterial infusion Hepatic arterial infusion Hepatic Arterial Infusion (HAI) is a medical procedure that delivers chemotherapy directly to the liver. The procedure, mostly used in combination with systemic chemotherapy, plays a role in the treatment of liver metastases in patients with colorectal cancer (CRC). Although surgical resection remains the standard of care for these liver metastases, majority of patients have lesions that are unresectable. The liver derives its blood supply from two sources – via the hepatic arterial circulation and the portal circulation. Liver metastases get most of their blood supply primarily from the hepatic artery, whereas the normal liver cells get
Protocol Relating to the Status of Refugees the temporal and geographic restrictions. This was needed in the historical context of refugee flows resulting from decolonisation. However, the Protocol gave those states which had previously ratified the 1951 Convention and chosen to use the geographically restricted definition the option to retain that restriction. Protocol Relating to the Status of Refugees The Protocol Relating to the Status of Refugees is a key treaty in international refugee law. It entered into force on 4 October 1967, and 146 countries are parties. Where the 1951 United Nations Convention Relating to the Status of Refugees had restricted refugee status to those whose