Vitamin C megadosage systemic conditioning ("rebound scurvy"), preoxidant effects, iron overload, reduced absorption of vitamin B12 and copper, increased oxygen demand, and acid erosion of the teeth with chewing ascorbic-acid tablets. In addition, one case has been noted of a woman who had received a kidney transplant followed by high-dose vitamin C and died soon afterwards as a result of calcium oxalate deposits that destroyed her new kidney. Her doctors concluded that high-dose vitamin C therapy should be avoided in patients with renal failure. As discussed previously, vitamin C generally exhibits low toxicity. The (the dose that will kill 50% of a population)
History of medicine in the Philippines surveyors of herbal medicines at the localities where they were assigned. Common disease during the Spanish period in the Philippines were diarrhea, dysentery, and leprosy. There were also the presence of cholera, inﬂuenza, smallpox, beri-beri, dysentery, bubonic plague, scurvy, rheumatism, asthma, syphilis, tetanus, toothache, and ulcers. Many Filipinos believed in "pasma" (a resulting condition similar to spasm which involves the occurrence of hand tremors, sweaty palms, numbness and pains after the body's exposure to "unhealthy cold" and water), the state of "nausog" ("distress" caused by an unfamiliar person), and "personalistic sorcery". It was in 1830 when the "true pharmacies" were