Vitamin C megadosage systemic conditioning ("rebound scurvy"), preoxidant effects, iron overload, reduced absorption of vitamin B12 and copper, increased oxygen demand, and acid erosion of the teeth with chewing ascorbic-acid tablets. In addition, one case has been noted of a woman who had received a kidney transplant followed by high-dose vitamin C and died soon afterwards as a result of calcium oxalate deposits that destroyed her new kidney. Her doctors concluded that high-dose vitamin C therapy should be avoided in patients with renal failure. As discussed previously, vitamin C generally exhibits low toxicity. The (the dose that will kill 50% of a population)
In the Days of the Comet he had been a great success at the university." Leadford's only close friend is a fellow clerk and socialist. But the pair quarrel and Leadford breaks off relations when Parload avers that socialism is "only a theory," whereas science is "something more". In later years Parload becomes a great scientist whose "work upon intersecting radiations has broadened the intellectual horizon of mankind for ever." Wells's open endorsement of polyamorous love at the end of "In the Days of the Comet" caused some scandal. Various organisations dedicated to preserving public morals, including the YWCA, Salvation Army and ‘Anti-Vice and White Slavery’