Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Your Body Is a Wonderland Bernard sing the song as a karaoke duet. Mayer agreed to let the show use the song, in exchange for a Dundie, which was for "Tallest Music Dude". In the episode of Family Guy titled "Stew-Roids", Stewie sings a song in which he pronounces the word "body" like "bah-dy", which he then explains "That's how John Mayer would say it"; a reference to the pronunciation of the word in "Your Body Is a Wonderland". Lance Bass and Lacey Schwimmer performed a rhumba to the song on Season 7 of "Dancing with the Stars". Your Body Is a Wonderland "Your Body