Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Nominalized adjective number and nominative case. "Den Alten" is a similar inflection but in the accusative case. The nominalized adjective is derived from the adjective "alt" and surfaces as it does by taking the appropriate inflection. Like in English, adjectival nouns are used as a plural definite ("the unemployed") and with nationality words ("the Swedish"). However, Swedish does not require "one or ones" with count nouns ("The old cat is slower than the new (one)"). The use of inflection, which incorporates the number and the gender of the noun, allows Swedish to avoid the need for a visible noun to describe a