Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
The Early Days of Guns N' Roses The Early Days of Guns N' Roses The Early Days of Guns N' Roses was what the first series of concerts by American hard rock band Guns N' Roses are referred to as. Before embarking on the Appetite for Destruction Tour in 1987 after the group's breakthrough success, the band played at least 60 shows. After playing a few shows with early members (Guns, Beich and Gardner) on June 6, 1985 the band played their first show with what became known as the "classic line-up" of singer Axl Rose, guitarists Slash and Izzy Stradlin, bassist Duff McKagan and drummer Steven