Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
The Great Australian Adjective and Dennis, however excusable, is not the most creditable feature of their writings." C. J. Dennis acknowledged this poem when he came to publish his own work, "The Austra-laise", which uses the same stylistic trick of leaving the reader to supply missing words of their choice. The Great Australian Adjective The Great Australian Adjective is a humorous poem by English writer and poet W. T. Goodge. It was first published in "The Bulletin" magazine on 11 December 1897, the Christmas issue of that publication, and later in the poet's only collection "Hits! Skits! and Jingles!". The poem was originally published