Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
History of medicine in the Philippines surveyors of herbal medicines at the localities where they were assigned. Common disease during the Spanish period in the Philippines were diarrhea, dysentery, and leprosy. There were also the presence of cholera, inﬂuenza, smallpox, beri-beri, dysentery, bubonic plague, scurvy, rheumatism, asthma, syphilis, tetanus, toothache, and ulcers. Many Filipinos believed in "pasma" (a resulting condition similar to spasm which involves the occurrence of hand tremors, sweaty palms, numbness and pains after the body's exposure to "unhealthy cold" and water), the state of "nausog" ("distress" caused by an unfamiliar person), and "personalistic sorcery". It was in 1830 when the "true pharmacies" were