Hepatic encephalopathy An imbalance between aromatic amino acids (phenylalanine, tryptophan and tyrosine) and branched-chain amino acids (leucine, isoleucine and valine) has been described; this would lead to the generation of false neurotransmitters (such octopamine and 2-hydroxyphenethylamine). Dysregulation of the serotonin system, too, has been reported. Depletion of zinc and accumulation of manganese may play a role. Inflammation elsewhere in the body may precipitate encephalopathy through the action of cytokines and bacterial lipopolysaccharide on astrocytes. The diagnosis of hepatic encephalopathy can only be made in the presence of confirmed liver disease (types A and C) or a portosystemic shunt (type B), as its
European Union and its Member States — Certain Measures Relating to the Energy Sector European Union and its Member States — Certain Measures Relating to the Energy Sector European Union and its Member States — Certain Measures Relating to the Energy Sector, DS476, is the formal name of a case brought by the Russian Federation against the European Union and its member states in the World Trade Organization's Dispute Settlement Body. The case was formally initiated with the filing of a complaint by Russia (in WTO terms, a "request for consultations") on April 30, 2014. The dispute concerns the EU's Third Energy Package, which consists of various two EU directives and EU regulations. Russia