Vitamin C symptoms are malaise and lethargy, progressing to shortness of breath, bone pain, bleeding gums, susceptibility to bruising, poor wound healing, and finally fever, convulsions and eventual death. Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or intravenous injection. Scurvy was known to Hippocrates in the classical era. The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747, and from 1796 lemon juice was issued to all
The Vitamin Shoppe 2015 study, led by Dr. Pieter A. Cohen of Harvard, found that three supplements — JetFuel Superburn, JetFuel T-300 and MX-LS7 — sold at Vitamin Shoppe contained BMPEA. In response, Vitamin Shoppe removed these products from shelves because the safety of these supplements were in question and may not comply with F.D.A. regulations. On January 19, 2007, independent laboratory ConsumerLab.com found 32.8 micrograms of lead per daily serving in Vitamin Shoppe's "Especially for Women" multivitamin. 15.3 micrograms is more than ten times the amount of lead permitted without a warning label in California, the only state to regulate lead in