American Revolutionary War British service in addition to 4,888 deserters; of the former, it is estimated 1,800 were killed in combat. Around 171,000 sailors served in the Royal Navy during the war; approximately a quarter of whom had been pressed into service. Around 1,240 were killed in battle, while an estimated 18,500 died from disease (1776–1780). The greatest killer at sea was scurvy, a disease caused by vitamin C deficiency. It was not until 1795 that scurvy was eradicated from the Royal Navy after the Admiralty declared lemon juice and sugar were to be issued among the standard daily rations of sailors. Around
Scurvy cured scurvy before any fatalities occurred. In 1907, an animal model which would eventually help to isolate and identify the "antiscorbutic factor" was discovered. Axel Holst and Theodor Frølich, two Norwegian physicians studying shipboard beriberi contracted by ship's crews in the Norwegian Fishing Fleet, wanted a small test mammal to substitute for the pigeons then used in beriberi research. They fed guinea pigs their test diet of grains and flour, which had earlier produced beriberi in their pigeons, and were surprised when classic scurvy resulted instead. This was a serendipitous choice of animal. Until that time, scurvy had not been