Hepatic encephalopathy treatment may benefit people with hepatic encephalopathy. LOLA lowers ammonia levels by increasing the generation of urea through the urea cycle, a metabolic pathway that removes ammonia by turning it into the neutral substance urea. LOLA may be combined with lactulose and/or rifaximin if these alone are ineffective at controlling symptoms. In those with cirrhosis, the risk of developing hepatic encephalopathy is 20% per year, and at any time about 30–45% of people with cirrhosis exhibit evidence of overt encephalopathy. The prevalence of minimal hepatic encephalopathy detectable on formal neuropsychological testing is 60–80%; this increases the likelihood of developing overt
European Union and its Member States — Certain Measures Relating to the Energy Sector European Union and its Member States — Certain Measures Relating to the Energy Sector European Union and its Member States — Certain Measures Relating to the Energy Sector, DS476, is the formal name of a case brought by the Russian Federation against the European Union and its member states in the World Trade Organization's Dispute Settlement Body. The case was formally initiated with the filing of a complaint by Russia (in WTO terms, a "request for consultations") on April 30, 2014. The dispute concerns the EU's Third Energy Package, which consists of various two EU directives and EU regulations. Russia