Vitamin C megadosage systemic conditioning ("rebound scurvy"), preoxidant effects, iron overload, reduced absorption of vitamin B12 and copper, increased oxygen demand, and acid erosion of the teeth with chewing ascorbic-acid tablets. In addition, one case has been noted of a woman who had received a kidney transplant followed by high-dose vitamin C and died soon afterwards as a result of calcium oxalate deposits that destroyed her new kidney. Her doctors concluded that high-dose vitamin C therapy should be avoided in patients with renal failure. As discussed previously, vitamin C generally exhibits low toxicity. The (the dose that will kill 50% of a population)
The Early Days of Guns N' Roses The Early Days of Guns N' Roses The Early Days of Guns N' Roses was what the first series of concerts by American hard rock band Guns N' Roses are referred to as. Before embarking on the Appetite for Destruction Tour in 1987 after the group's breakthrough success, the band played at least 60 shows. After playing a few shows with early members (Guns, Beich and Gardner) on June 6, 1985 the band played their first show with what became known as the "classic line-up" of singer Axl Rose, guitarists Slash and Izzy Stradlin, bassist Duff McKagan and drummer Steven