Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Nominalized adjective elaborated by Noam Chomsky, it is suggested that inflected adjectives are more likely to be nominalized because they have overtly-marked φ-features (such as grammatical number and gender), which makes them suitable for use as the complement of a determiner. Determiners with unvalued φ-features must find a complement with a valued φ-feature to meet semantic comprehension. In the diagrams below, the determiner is "the", and its complement is either the noun phrase "poor people" or the nominalized adjective "poor". As the frequency of nominalized adjective use decreased, the frequency of structures using the prop-word "one" increased (phrases such as "the large"