Hepatic encephalopathy treatment may benefit people with hepatic encephalopathy. LOLA lowers ammonia levels by increasing the generation of urea through the urea cycle, a metabolic pathway that removes ammonia by turning it into the neutral substance urea. LOLA may be combined with lactulose and/or rifaximin if these alone are ineffective at controlling symptoms. In those with cirrhosis, the risk of developing hepatic encephalopathy is 20% per year, and at any time about 30–45% of people with cirrhosis exhibit evidence of overt encephalopathy. The prevalence of minimal hepatic encephalopathy detectable on formal neuropsychological testing is 60–80%; this increases the likelihood of developing overt
Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine availability of organs from a deceased person. Any removed parts of the body must be disposed of respectfully in accordance with the wishes of the individual. In addition, there is to be no financial gain arising from the human body or its parts, however adequate compensation for expenses incurred for a medical procedure is not prohibited. The rules relating to consent laid out in "Chapter II" of the Convention also apply in the context of organ transplantation. In accordance with the European Convention on Human Rights, any individual who has suffered damage should have access to fair compensation ("Article 24").