Vitamin C symptoms are malaise and lethargy, progressing to shortness of breath, bone pain, bleeding gums, susceptibility to bruising, poor wound healing, and finally fever, convulsions and eventual death. Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or intravenous injection. Scurvy was known to Hippocrates in the classical era. The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747, and from 1796 lemon juice was issued to all
The Place Promised in Our Early Days the Tokyo International Forum Hall C venue in Tokyo and 2 performances on May 02, 2018, at the NHK Osaka Hall venue in Osaka. The cast includes Yudai Tatsumi, Shô Takada, Momoka Ito, Kazuyuki Matsuzawa, Wataru Kozuki, Atsuko Asano, and others. The Place Promised in Our Early Days Unlike his short film "Voices of a Distant Star", which was largely made by Shinkai on his own, "The Place Promised in Our Early Days" is a full-scale production, as reflected by the better animation quality and the longer overall length. It has been broadcast across Japan by the anime satellite television