Prairie dog in prairie species such as the black-footed ferret, swift fox, golden eagle, red tailed hawk, American badger, coyote and ferruginous hawk. Other species, such as the golden-mantled ground squirrel, mountain plover, and the burrowing owl, also rely on prairie dog burrows for nesting areas. Even grazing species, such as plains bison, pronghorn, and mule deer have shown a proclivity for grazing on the same land used by prairie dogs. Nevertheless, prairie dogs are often identified as pests and exterminated from agricultural properties because they are capable of damaging crops, as they clear the immediate area around their burrows of most
Prairie dog classed as a "prohibited new organism" under New Zealand's Hazardous Substances and New Organisms Act 1996, preventing it from being imported into the country. Prairie dogs are also very susceptible to bubonic plague, and many wild colonies have been wiped out by it. Also, in 2002, a large group of prairie dogs in captivity in Texas were found to have contracted tularemia. The prairie dog ban is frequently cited by the CDC as a successful response to the threat of zoonosis. Prairie dogs that were in captivity at the time of the ban in 2003 were allowed to be kept