Hepatic lipase released into the bloodstream. Another lipoprotein, ApoA-I, which increases release of HDL was shown to have a similar effect by mutating the gene that coded it. Mutated ApoA-I protein caused a decrease in HL release and thus decreased the amount of HL bound to HDL and released into the bloodstream. Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated high density lipoprotein (HDL) cholesterol due to a mutation in the hepatic lipase gene. Clinical features are not well understood and there are no characteristic xanthomas. There is an association with a delay in atherosclerosis in an
British Institute of Organ Studies British Institute of Organ Studies The British Institute of Organ Studies, more commonly known by its acronym BIOS, is a British organisation and registered charity which aims to promote study and appreciation of all aspects of the pipe organ. Further, it acts as a lobbying body to raise awareness of organ issues with appropriate statutory bodies. Membership is open to all. The aims of BIOS are BIOS publishes a quarterly Reporter newsletter and magazine and a yearly Journal which contains articles on organ history. BIOS is also responsible for the National Pipe Organ Register (NPOR), which aims to catalogue all