Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
Scurvy like Gilbert Blane and Thomas Trotter and by the reports of up-and-coming naval commanders. With the coming of war in 1793, the need to eliminate scurvy acquired a new urgency. But the first initiative came not from the medical establishment but from the admirals. Ordered to lead an expedition against Mauritius, Rear Admiral Gardner was uninterested in the wort, malt and elixir of vitriol which were still being issued to ships of the Royal Navy, and demanded that he be supplied with lemons, to counteract scurvy on the voyage. Members of the Sick and Hurt Board, recently augmented by two