Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Postpositive adjective Postpositive adjective A postpositive or postnominal adjective is an attributive adjective that is placed after the noun or pronoun that it modifies. This contrasts with prepositive adjectives, which come before the noun or pronoun. In some languages the postpositive placement of adjectives is the normal syntax, but in English it is less usual, largely confined to archaic and poetic uses (as in "They heard wights unseen), phrases loaned from Romance languages or Latin (such as "heir apparent, "aqua regia"), and certain particular grammatical constructions (as in "those anxious to leave"). Recognizing postpositive adjectives in English is important for determining the