Vitamin C megadosage systemic conditioning ("rebound scurvy"), preoxidant effects, iron overload, reduced absorption of vitamin B12 and copper, increased oxygen demand, and acid erosion of the teeth with chewing ascorbic-acid tablets. In addition, one case has been noted of a woman who had received a kidney transplant followed by high-dose vitamin C and died soon afterwards as a result of calcium oxalate deposits that destroyed her new kidney. Her doctors concluded that high-dose vitamin C therapy should be avoided in patients with renal failure. As discussed previously, vitamin C generally exhibits low toxicity. The (the dose that will kill 50% of a population)
The Days of the Turbins people, caused furore. In its first season, in 1926/1927 "The Days of the Turbins" ran for 108 performance, which was a record figure that year for Moscow theatres. Despite numerous attempts at obstructions, it became a huge a hit, especially with the non-party public. The Soviet press panned it, though, and as the time went by, the severity of the criticism increased. In April 1929 the MAT leadership succumbed to the pressure and the production was cancelled. On 28 March 1930 Bulgakov sent a letter to the Soviet government, protesting against the treatment that the play had been subjected to