Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Proper adjective Proper adjective In English orthography, the term proper adjective is sometimes applied to adjectives that take initial capital letters, and the term common adjective to those that do not. For example, a person from Boston is Bostonian. "Bostonian" is a proper adjective. These terms are used informally only; they are not used by grammarians or linguists. The term "proper noun" denotes a noun that, grammatically speaking, identifies a specific unique entity; for example, "England" is a proper noun, because it is a name for a specific country, whereas "dog" is not a proper noun; it is, rather, a "common noun"