Common hepatic duct who have had their gallbladder removed. It is an important anatomic landmark during surgeries such as gall bladder removal. It forms one edge of Calot's triangle, along with the cystic duct and the cystic artery. All constituents of this triangle must be identified to avoid cutting or clipping the wrong structure. There is some normal anatomic variation of the diameter. The common hepatic duct is about 6mm in diameter in adults, with some variation. A diameter of more than 8 mm is regarded as abnormal dilatation, and is a sign of cholestasis. Common hepatic duct The common hepatic duct is
Organ-on-a-chip models that replicate aspects of the human body as closely as possible and give examples that demonstrate their potential use in drug development, such as identifying synergistic drug interactions as well as simulating multi-organ metabolic interactions. Multi compartment micro fluidic-based devices, particularly those that are physical representations of physiologically based pharmacokinetic (PBPK) models that represent the mass transfer of compounds in compartmental models of the mammalian body, may contribute to improving the drug development process. Mathematical pharmacokinetic (PK) models aim to estimate concentration-time profiles within each organ on the basis of the initial drug dose. Such mathematical models can be