Vitamin C symptoms are malaise and lethargy, progressing to shortness of breath, bone pain, bleeding gums, susceptibility to bruising, poor wound healing, and finally fever, convulsions and eventual death. Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or intravenous injection. Scurvy was known to Hippocrates in the classical era. The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747, and from 1796 lemon juice was issued to all
The Days of the Turbins people, caused furore. In its first season, in 1926/1927 "The Days of the Turbins" ran for 108 performance, which was a record figure that year for Moscow theatres. Despite numerous attempts at obstructions, it became a huge a hit, especially with the non-party public. The Soviet press panned it, though, and as the time went by, the severity of the criticism increased. In April 1929 the MAT leadership succumbed to the pressure and the production was cancelled. On 28 March 1930 Bulgakov sent a letter to the Soviet government, protesting against the treatment that the play had been subjected to