Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
History of the Royal Navy and England's Royal Navy were organised as one force, though not technically merged, as a consequence of the Union of the Crowns when James VI of Scotland became King of England also, as James I. Though the Lord of the Isles had a large fleet of galleys in the 13th and 14th centuries, there appears little or no trace of a Scots navy during the Wars of Scottish Independence. With Scottish independence established, Robert the Bruce turned his attention to the upbuilding of Scots shipping and of a Scots navy. In his later days he visited the Western Isles, which