Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
European Union and its Member States — Certain Measures Relating to the Energy Sector European Union and its Member States — Certain Measures Relating to the Energy Sector European Union and its Member States — Certain Measures Relating to the Energy Sector, DS476, is the formal name of a case brought by the Russian Federation against the European Union and its member states in the World Trade Organization's Dispute Settlement Body. The case was formally initiated with the filing of a complaint by Russia (in WTO terms, a "request for consultations") on April 30, 2014. The dispute concerns the EU's Third Energy Package, which consists of various two EU directives and EU regulations. Russia