Health and diet in Elizabethan England upper classes ate fine white bread called manchet while the poor ate coarse bread of barley or rye. Both the rich and the poor had imbalanced diets. The lack of vegetables and fruits in their diets caused a deficiency in vitamin C, sometimes resulting in scurvy. Trade and industry flourished in the 16th century, making England more prosperous and improving the standard of living of the upper and middle classes. However, the lower classes did not benefit much and did not always have enough food. As the English population was fed by its own agricultural produce, a series of bad
Scurvy cured scurvy before any fatalities occurred. In 1907, an animal model which would eventually help to isolate and identify the "antiscorbutic factor" was discovered. Axel Holst and Theodor Frølich, two Norwegian physicians studying shipboard beriberi contracted by ship's crews in the Norwegian Fishing Fleet, wanted a small test mammal to substitute for the pigeons then used in beriberi research. They fed guinea pigs their test diet of grains and flour, which had earlier produced beriberi in their pigeons, and were surprised when classic scurvy resulted instead. This was a serendipitous choice of animal. Until that time, scurvy had not been