Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective in context. Determiners generally do this by indicating definiteness (as in "a" vs. "the"), quantity (as in "one" vs. "some" vs. "many"), or another such property. An adjective acts as the head of an "adjective phrase" or "adjectival phrase" (AP). In the simplest case, an adjective phrase consists solely of the adjective; more complex adjective phrases may contain one or more adverbs modifying the adjective (""very" strong"), or one or more complements (such as "worth "several dollars"", "full "of toys"", or "eager "to please""). In English, attributive adjective phrases that include complements typically follow the noun that they qualify ("an