Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
The Place Promised in Our Early Days the Tokyo International Forum Hall C venue in Tokyo and 2 performances on May 02, 2018, at the NHK Osaka Hall venue in Osaka. The cast includes Yudai Tatsumi, Shô Takada, Momoka Ito, Kazuyuki Matsuzawa, Wataru Kozuki, Atsuko Asano, and others. The Place Promised in Our Early Days Unlike his short film "Voices of a Distant Star", which was largely made by Shinkai on his own, "The Place Promised in Our Early Days" is a full-scale production, as reflected by the better animation quality and the longer overall length. It has been broadcast across Japan by the anime satellite television