Prairie dog and Clark in 1804. Lewis described it in more detail in 1806, calling it the "barking squirrel". On average, these stout-bodied rodents will grow to be between long, including the short tail, and weigh between . Sexual dimorphism in body mass in the prairie dog varies 105 to 136% between the sexes. Among the species, black-tailed prairie dogs tend to be the least sexually dimorphic, and white-tailed prairie dogs tend to be the most sexually dimorphic. Sexual dimorphism peaks during weaning, when the females lose weight and the males start eating more, and is at its lowest when the females
Black-tailed prairie dog does not significantly affect steer weights. While forage availability and use by cattle decreased in black-tailed prairie dog foraging areas, steer weight was not reduced significantly in either of two years of study at the USDA's Southern Great Plains Experimental Range near Woodward, Oklahoma. Nutrient cycling, increased soil fertility, and subsequent changes in forage quality partly compensated for reduced forage availability. Black-tailed prairie dogs were the most common prairie dog species collected in the wild for sale as exotic pets, until this trade was banned in 2003 by the United States federal government. Prairie dogs in captivity at the time