Hepatic stellate cell fat-staining method to identify the "fat-storing cells" of the liver. Hepatic stellate cell Hepatic stellate cells (here HSC), also known as perisinusoidal cells or Ito cells (earlier "lipocytes" or "fat-storing cells"), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes). The stellate cell is the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. Hepatic stellate cells can be selectively stained with gold chloride, but their distinguishing feature in routine histological preparations is the
Protocol Relating to the Status of Refugees the temporal and geographic restrictions. This was needed in the historical context of refugee flows resulting from decolonisation. However, the Protocol gave those states which had previously ratified the 1951 Convention and chosen to use the geographically restricted definition the option to retain that restriction. Protocol Relating to the Status of Refugees The Protocol Relating to the Status of Refugees is a key treaty in international refugee law. It entered into force on 4 October 1967, and 146 countries are parties. Where the 1951 United Nations Convention Relating to the Status of Refugees had restricted refugee status to those whose