Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective phrase that have their head adjective on the right side of the phrase: The labels on the nodes in the trees are acronyms: A = adjective, Adv = adverb, AP = adjective phrase, N = noun/pronoun, P = preposition, PP = prepositional phrase. The constituency trees identify these phrases as adjective phrases by labeling the top node with AP, and the dependency trees accomplish the same thing by positioning the A node at the top of the tree. The following trees illustrate the structure of head-initial adjective phrases, i.e. adjective phrases that have their head on the left side of the