Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Proper adjective adjectives. In general, an adjective is capitalized if its meaning is "pertaining to "X"", where "X" is some specific person, place, language, or organized group. Most capitalized adjectives are derived from proper nouns; for example, the proper adjective "American" is derived from the proper noun "America". Sometimes, an adjective is capitalized because it designates an ethnic group with a shared culture, heritage, or ancestry. This usage asserts the existence of a unified group with common goals. For example, in Canadian government documents, "Native" and "Aboriginal" are capitalized. An adjective can lose its capitalization when it takes on new meanings, such