Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Adjective where English uses "to be hungry" ("hungry" being an adjective), Dutch, French, and Spanish use "honger hebben", "avoir faim", and "tener hambre" respectively (literally "to have hunger", the words for "hunger" being nouns). Similarly, where Hebrew uses the adjective זקוק "zaqūq" (roughly "in need of"), English uses the verb "to need". In languages which have adjectives as a word class, they are usually an open class; that is, it is relatively common for new adjectives to be formed via such processes as derivation. However, Bantu languages are well known for having only a small closed class of adjectives, and new