Hepatic lipase often found bound to HSPG, heparan sulfate proteoglycans (HSPG), keeping HL inactive and unable to bind to HDL (high density lipoprotein) or IDL (intermediate density lipoprotein). When it is free in the bloodstream, however, it is found associated with HDL to maintain it inactive. This is because the triacylglycerides in HDL serve as a substrate, but the lipoprotein contains proteins around the triacylglycerides that can prevent the triacylglycerides from being broken down by HL. One of the principal functions of hepatic lipase is to convert intermediate-density lipoprotein (IDL) to low-density lipoprotein (LDL). Hepatic lipase thus plays an important role in
Your Body Is a Wonderland Bernard sing the song as a karaoke duet. Mayer agreed to let the show use the song, in exchange for a Dundie, which was for "Tallest Music Dude". In the episode of Family Guy titled "Stew-Roids", Stewie sings a song in which he pronounces the word "body" like "bah-dy", which he then explains "That's how John Mayer would say it"; a reference to the pronunciation of the word in "Your Body Is a Wonderland". Lance Bass and Lacey Schwimmer performed a rhumba to the song on Season 7 of "Dancing with the Stars". Your Body Is a Wonderland "Your Body