Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
The Days of the Turbins people, caused furore. In its first season, in 1926/1927 "The Days of the Turbins" ran for 108 performance, which was a record figure that year for Moscow theatres. Despite numerous attempts at obstructions, it became a huge a hit, especially with the non-party public. The Soviet press panned it, though, and as the time went by, the severity of the criticism increased. In April 1929 the MAT leadership succumbed to the pressure and the production was cancelled. On 28 March 1930 Bulgakov sent a letter to the Soviet government, protesting against the treatment that the play had been subjected to