Vitamin C megadosage in combination with other therapies, but this does not imply vitamin C megadoses in themselves have therapeutic effect. The World Health Organization recommends a daily intake of 45 mg/day of vitamin C for healthy adults, and 25–30 mg/day in infants. The Vitamin C article provides examples of recommendations from individual countries. None exceed 110 mg/day. Vitamin C is necessary for production of collagen and other biomolecules, and for the prevention of scurvy. Vitamin C is an antioxidant, which has led to its endorsement by some researchers as a complementary therapy for improving quality of life. Since the 1930s, when it
Scurvy belief that scurvy was fundamentally a nutritional deficiency, best treated by consumption of fresh food, particularly fresh citrus or fresh meat, was not universal in the 19th and early 20th centuries, and thus sailors and explorers continued to suffer from scurvy into the 20th century. For example, the Belgian Antarctic Expedition of 1897–1899 became seriously affected by scurvy when its leader, Adrien de Gerlache, initially discouraged his men from eating penguin and seal meat. In the Royal Navy's Arctic expeditions in the 19th century it was widely believed that scurvy was prevented by good hygiene on board ship, regular exercise,