Hepatic stellate cell fat-staining method to identify the "fat-storing cells" of the liver. Hepatic stellate cell Hepatic stellate cells (here HSC), also known as perisinusoidal cells or Ito cells (earlier "lipocytes" or "fat-storing cells"), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes). The stellate cell is the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. Hepatic stellate cells can be selectively stained with gold chloride, but their distinguishing feature in routine histological preparations is the
Organ-on-a-chip models that replicate aspects of the human body as closely as possible and give examples that demonstrate their potential use in drug development, such as identifying synergistic drug interactions as well as simulating multi-organ metabolic interactions. Multi compartment micro fluidic-based devices, particularly those that are physical representations of physiologically based pharmacokinetic (PBPK) models that represent the mass transfer of compounds in compartmental models of the mammalian body, may contribute to improving the drug development process. Mathematical pharmacokinetic (PK) models aim to estimate concentration-time profiles within each organ on the basis of the initial drug dose. Such mathematical models can be