Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Scotch (adjective) ma Scotch blue bell." Scotch (adjective) Scotch is an adjective meaning "of Scotland". The modern usage in Scotland is Scottish or Scots, and the word "Scotch" is only applied to specific products, mostly food or drink, such as Scotch whisky, Scotch pie, Scotch broth, and Scotch eggs. "Scotch" applied to people is widely considered pejorative in Scotland, reflecting old Anglo-Scottish antagonisms, but it is still occasionally used in England and Ireland, though the usage is considered old-fashioned. The verb "to scotch" is unrelated to the adjective. It derives from Anglo-French "escocher" meaning "to notch, nick", from "coche", "a notch, groove",