Vitamin C megadosage systemic conditioning ("rebound scurvy"), preoxidant effects, iron overload, reduced absorption of vitamin B12 and copper, increased oxygen demand, and acid erosion of the teeth with chewing ascorbic-acid tablets. In addition, one case has been noted of a woman who had received a kidney transplant followed by high-dose vitamin C and died soon afterwards as a result of calcium oxalate deposits that destroyed her new kidney. Her doctors concluded that high-dose vitamin C therapy should be avoided in patients with renal failure. As discussed previously, vitamin C generally exhibits low toxicity. The (the dose that will kill 50% of a population)
The Place Promised in Our Early Days the Tokyo International Forum Hall C venue in Tokyo and 2 performances on May 02, 2018, at the NHK Osaka Hall venue in Osaka. The cast includes Yudai Tatsumi, Shô Takada, Momoka Ito, Kazuyuki Matsuzawa, Wataru Kozuki, Atsuko Asano, and others. The Place Promised in Our Early Days Unlike his short film "Voices of a Distant Star", which was largely made by Shinkai on his own, "The Place Promised in Our Early Days" is a full-scale production, as reflected by the better animation quality and the longer overall length. It has been broadcast across Japan by the anime satellite television