Hepatic encephalopathy treatment may benefit people with hepatic encephalopathy. LOLA lowers ammonia levels by increasing the generation of urea through the urea cycle, a metabolic pathway that removes ammonia by turning it into the neutral substance urea. LOLA may be combined with lactulose and/or rifaximin if these alone are ineffective at controlling symptoms. In those with cirrhosis, the risk of developing hepatic encephalopathy is 20% per year, and at any time about 30–45% of people with cirrhosis exhibit evidence of overt encephalopathy. The prevalence of minimal hepatic encephalopathy detectable on formal neuropsychological testing is 60–80%; this increases the likelihood of developing overt
Nominalized adjective Nominalized adjective A nominalized adjective is an adjective that has undergone nominalization, and is thus used as a noun. For example, in "the rich and the poor", the adjectives "rich" and "poor" function as nouns denoting people who are rich and poor respectively. The most common appearance of the nominalized adjective in English is when an adjective is used to indicate a collective group. This happens in the case where a phrase such as "the poor people" becomes "the poor". The adjective "poor" is nominalized, and the noun "people" disappears. Other adjectives commonly used in this way include "rich", "wealthy",