Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Collateral adjective Collateral adjective A collateral adjective is an adjective that is identified with a particular noun in meaning, but that is not derived from that noun. For example, the word "bovine" is considered the adjectival equivalent of the noun "cow", but it is derived from a different word, which happens to be the Latin word for "cow". Similarly, "lunar" serves as an adjective to describe attributes of the Moon; "moon" comes from Old English "mōna" "moon" and "lunar" from Latin "luna" "moon". The adjective "thermal" and the noun "heat" have a similar semantic relationship. As in these examples, the collateral adjective