Hepatic encephalopathy treatment may benefit people with hepatic encephalopathy. LOLA lowers ammonia levels by increasing the generation of urea through the urea cycle, a metabolic pathway that removes ammonia by turning it into the neutral substance urea. LOLA may be combined with lactulose and/or rifaximin if these alone are ineffective at controlling symptoms. In those with cirrhosis, the risk of developing hepatic encephalopathy is 20% per year, and at any time about 30–45% of people with cirrhosis exhibit evidence of overt encephalopathy. The prevalence of minimal hepatic encephalopathy detectable on formal neuropsychological testing is 60–80%; this increases the likelihood of developing overt
Spermaceti organ Spermaceti organ The spermaceti organ is an organ that commonly appears in the heads of toothed whales of the family Physeteroidea, in particular the sperm whale. This organ contains a waxy liquid called spermaceti and is involved in the generation of sound. In the modern day Great Sperm Whale ("Physeter macrocephalus"), the spermaceti organ is far larger in proportion to the animal’s body than what would be explained by simple allometry, and the evolution of the organ has caused changes in basal skull morphology, which may implicate tradeoffs were made that compromised the functionality of other nearby features. The high