Hepatic arterial infusion placement of the pump, technical catheter-related complications, and those related to the chemotherapeutic agents used. Relating to the surgical HAI pump placement, early postoperative complications consist of arterial injury leading to hepatic artery thrombosis, inadequate perfusion of the entire liver due to the inability to identify an accessory hepatic artery, extrahepatic perfusion to the stomach or duodenum, or hematoma formation in the subcutaneous pump pocket. Late complications are more common and include inflammation or ulceration of the stomach or duodenum, and pump pocket infection. The most common catheter related complications include displacement of the catheter, occlusion of the hepatic artery
Organ-on-a-chip models that replicate aspects of the human body as closely as possible and give examples that demonstrate their potential use in drug development, such as identifying synergistic drug interactions as well as simulating multi-organ metabolic interactions. Multi compartment micro fluidic-based devices, particularly those that are physical representations of physiologically based pharmacokinetic (PBPK) models that represent the mass transfer of compounds in compartmental models of the mammalian body, may contribute to improving the drug development process. Mathematical pharmacokinetic (PK) models aim to estimate concentration-time profiles within each organ on the basis of the initial drug dose. Such mathematical models can be