Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Nominalized adjective Nominalized adjective A nominalized adjective is an adjective that has undergone nominalization, and is thus used as a noun. For example, in "the rich and the poor", the adjectives "rich" and "poor" function as nouns denoting people who are rich and poor respectively. The most common appearance of the nominalized adjective in English is when an adjective is used to indicate a collective group. This happens in the case where a phrase such as "the poor people" becomes "the poor". The adjective "poor" is nominalized, and the noun "people" disappears. Other adjectives commonly used in this way include "rich", "wealthy",