Hepatic stellate cell A decreases progressively in liver injury. The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis. More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence in these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician, who introduced a
Proper adjective as "chauvinistic". In addition, over time, an adjective can lose its capitalization by convention, generally when the word has overshadowed its original reference, such as "gargantuan", "quixotic", "titanic", or "roman" in the term "roman numerals". An adverb formed from a capitalized adjective is itself capitalized. For example: Verbs such as "Canadianize" are written with a capital letter, although not generally described as "proper verbs". Proper adjective In English orthography, the term proper adjective is sometimes applied to adjectives that take initial capital letters, and the term common adjective to those that do not. For example, a person from Boston is