Vitamin C and the common cold but it has halved the frequency of colds in people under heavy short-term physical stress. There is no effect of taking vitamin C in doses up to 8 grams per day after a cold has already begun. Vitamin C was identified in the early part of the twentieth century, and there was much interest in its possible effects on various infections including the common cold. A few controlled trials on the effect of vitamin C on the common cold were carried out already in the 1940s, the earliest of these appears to be a placebo-controlled trial published in 1945. The
Scurvy belief that scurvy was fundamentally a nutritional deficiency, best treated by consumption of fresh food, particularly fresh citrus or fresh meat, was not universal in the 19th and early 20th centuries, and thus sailors and explorers continued to suffer from scurvy into the 20th century. For example, the Belgian Antarctic Expedition of 1897–1899 became seriously affected by scurvy when its leader, Adrien de Gerlache, initially discouraged his men from eating penguin and seal meat. In the Royal Navy's Arctic expeditions in the 19th century it was widely believed that scurvy was prevented by good hygiene on board ship, regular exercise,