Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
The History of Iron Maiden – Part 1: The Early Days The History of Iron Maiden – Part 1: The Early Days The History of Iron Maiden – Part 1: The Early Days is a DVD video by Iron Maiden, released in 2004. It features the first part of "The History of Iron Maiden" series, a 90-minute documentary which describes their beginnings in London's East End in 1975 through to the "Piece of Mind" album and tour in 1983. The set also features a large collection of rare videos and concert footage, as well as interviews with former members such as Paul Di'Anno, Clive Burr, Dennis Stratton, Dave Sullivan, Terry Rance,