Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
History of the United States Navy ended by the Treaty of Paris in 1783, and by 1785 the Continental Navy was disbanded and the remaining ships were sold. The frigate , which had fired the last shots of the American Revolutionary War, was also the last ship in the Navy. A faction within Congress wanted to keep the ship, but the new nation did not have the funds to keep her in service. Other than a general lack of money, factors for the disarmament of the navy were the loose confederation of the states, a change of goals from war to peace, and more domestic and