Vitamin C megadosage the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB. A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half. A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses in the range from 0.5 to 4
In the Days of the Comet he had been a great success at the university." Leadford's only close friend is a fellow clerk and socialist. But the pair quarrel and Leadford breaks off relations when Parload avers that socialism is "only a theory," whereas science is "something more". In later years Parload becomes a great scientist whose "work upon intersecting radiations has broadened the intellectual horizon of mankind for ever." Wells's open endorsement of polyamorous love at the end of "In the Days of the Comet" caused some scandal. Various organisations dedicated to preserving public morals, including the YWCA, Salvation Army and ‘Anti-Vice and White Slavery’