History of variational principles in physics involves integrals over an interval of time and (for fields) extended region of space. Moreover, in the usual formulation of classical action principles, the initial and final states of the system are fixed, e.g., In particular, the fixing of the "final" state appears to give the action principle a teleological character which has been controversial historically. This apparent teleology is eliminated in the quantum mechanical version of the action principle. History of variational principles in physics A variational principle in physics is an alternative method for determining the state or dynamics of a physical system, by identifying it as an
Minimum Information Standards HUPO-PSI (www.psidev.info) and describes the Minimum Information about a Molecular Interaction experiment. The Minimum Information About a Protein Affinity Reagent has been developed and maintained by the Molecular Interaction worktrack of the HUPO-PSI (www.psidev.info)in conjunction with the HUPO Antibody Initiative and a European consortium of binder producers and seeks to encourage users to improve their description of binding reagents, such as antibodies, used in the process of protein identification. The Minimum Information About a Bioactive Entity was produced by representatives from both large pharma and academia who are looking to improve the description of usually small molecules which bind to,