Prairie dog in prairie species such as the black-footed ferret, swift fox, golden eagle, red tailed hawk, American badger, coyote and ferruginous hawk. Other species, such as the golden-mantled ground squirrel, mountain plover, and the burrowing owl, also rely on prairie dog burrows for nesting areas. Even grazing species, such as plains bison, pronghorn, and mule deer have shown a proclivity for grazing on the same land used by prairie dogs. Nevertheless, prairie dogs are often identified as pests and exterminated from agricultural properties because they are capable of damaging crops, as they clear the immediate area around their burrows of most
Black-tailed prairie dog eagles ("Aquila chrysaetos"), ferruginous hawks ("Buteo regalis"), red-tailed hawks ("Buteo jamaicensis"), and prairie rattlesnakes ("Crotalus viridis"). Although now very rare, black-footed ferrets ("Mustela nigripes") were once a major predator of the black-tailed prairie dog. Black-tailed prairie dogs have been called "ecosystem engineers" due to their influence on the biotic and abiotic characteristics of their habitat, landscape architecture, and ecosystem structure and function. Research suggests black-tailed prairie dogs are a keystone species in some, but not all, geographic areas. Black-tailed prairie dogs enhance the diversity of vegetation, vertebrates, and invertebrates through their foraging and burrowing activities and by their presence as