Vitamin C megadosage systemic conditioning ("rebound scurvy"), preoxidant effects, iron overload, reduced absorption of vitamin B12 and copper, increased oxygen demand, and acid erosion of the teeth with chewing ascorbic-acid tablets. In addition, one case has been noted of a woman who had received a kidney transplant followed by high-dose vitamin C and died soon afterwards as a result of calcium oxalate deposits that destroyed her new kidney. Her doctors concluded that high-dose vitamin C therapy should be avoided in patients with renal failure. As discussed previously, vitamin C generally exhibits low toxicity. The (the dose that will kill 50% of a population)
The Vitamin Shoppe 2015 study, led by Dr. Pieter A. Cohen of Harvard, found that three supplements — JetFuel Superburn, JetFuel T-300 and MX-LS7 — sold at Vitamin Shoppe contained BMPEA. In response, Vitamin Shoppe removed these products from shelves because the safety of these supplements were in question and may not comply with F.D.A. regulations. On January 19, 2007, independent laboratory ConsumerLab.com found 32.8 micrograms of lead per daily serving in Vitamin Shoppe's "Especially for Women" multivitamin. 15.3 micrograms is more than ten times the amount of lead permitted without a warning label in California, the only state to regulate lead in