Drug discovery crude preparations are morphine, the active agent in opium, and digoxin, a heart stimulant originating from Digitalis lanata. Organic chemistry also led to the synthesis of many of the natural products isolated from biological sources. Historically, substances, whether crude extracts or purified chemicals, were screened for biological activity without knowledge of the biological target. Only after an active substance was identified was an effort made to identify the target. This approach is known as classical pharmacology, forward pharmacology, or phenotypic drug discovery. Later, small molecules were synthesized to specifically target a known physiological/pathological pathway, avoiding the mass screening of banks
Mountaineer Power Plant that coal now comes via barge on the Ohio River to an elaborate coal unloading and storage facility.The other portion of coal comes from Big River Mining. An underground coal mine right across the street from the plant. It is mined, cleaned, processed, and shipped by a belt line across the street to the power plant. This single boiler, dual turbine plant produces enough energy to power a city approximately the size of Columbus, Ohio. The plant is connected to the grid by 765 kilovolt transmission lines (the highest rated voltage used in the United States). The location of the