Drug discovery crude preparations are morphine, the active agent in opium, and digoxin, a heart stimulant originating from Digitalis lanata. Organic chemistry also led to the synthesis of many of the natural products isolated from biological sources. Historically, substances, whether crude extracts or purified chemicals, were screened for biological activity without knowledge of the biological target. Only after an active substance was identified was an effort made to identify the target. This approach is known as classical pharmacology, forward pharmacology, or phenotypic drug discovery. Later, small molecules were synthesized to specifically target a known physiological/pathological pathway, avoiding the mass screening of banks
Nothing comes from nothing the song "Something Good", which contains the lyrics: "Nothing comes from nothing / nothing ever could". Although the song is devoid of intentional metaphysical connotations, Maria's time in Nonnberg Abbey would have familiarized her with the phrase, which is used in Catholic philosophy to explain God's gratuitous act of , namely, that only the source of all being can give creation its existence. Earlier in the film, in the well-known song "Maria", Maria's fellow nuns lament that there is "many a thing she ought to understand" and that she is "not an asset to the abbey". It is unclear if