Drug discovery crude preparations are morphine, the active agent in opium, and digoxin, a heart stimulant originating from Digitalis lanata. Organic chemistry also led to the synthesis of many of the natural products isolated from biological sources. Historically, substances, whether crude extracts or purified chemicals, were screened for biological activity without knowledge of the biological target. Only after an active substance was identified was an effort made to identify the target. This approach is known as classical pharmacology, forward pharmacology, or phenotypic drug discovery. Later, small molecules were synthesized to specifically target a known physiological/pathological pathway, avoiding the mass screening of banks
Tyseley Energy from Waste Plant Tyseley Energy from Waste Plant Tyseley Energy Recovery Facility is a waste incineration plant in Birmingham, UK. It is run by Veolia. It was built in 1996 by Veolia to a design by Faulks Perry Culley & Rech. The plant has become a notable building in Birmingham with a lighting scheme that illuminates the plant during the hours of darkness. It was built to comply with the European emissions standards that came into force in 1996. Veolia benefits from Levy Exemption Certificates for the element of energy which is produced from renewable sources. This provides income to the City Council.