Digitalis digitalis. As a result of increased contractility, stroke volume is increased. Ultimately, digitalis increases cardiac output (Cardiac Output=Stroke Volume x Heart Rate). This is the mechanism that makes this drug a popular treatment for congestive heart failure, which is characterized by low cardiac output. Digitalis also has a vagal effect on the parasympathetic nervous system, and as such is used in re-entrant cardiac arrhythmias and to slow the ventricular rate during atrial fibrillation. The dependence on the vagal effect means digitalis is not effective when a patient has a high sympathetic nervous system drive, which is the case with acutely
The Sun Comes Out Tonight lyrics and album title was Patrick's prior issues with alcoholism and excessive drug use. Patrick explained it as: In my lifetime, the sun definitely came out at night... I’m a recovering drug addict and a recovering alcoholic, but when I was taking drugs, there were a few nights where my blood turned into golden, beautiful sunshine. It was all chemical-based, and I knew it was a lie, but it was completely overwhelming, and it was like the sun had come out at night." Patrick changed the album title from "Gurney" to "The Sun Comes Out Tonight" after feeling so inspired