Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
The Sun Comes Out Tonight lyrics and album title was Patrick's prior issues with alcoholism and excessive drug use. Patrick explained it as: In my lifetime, the sun definitely came out at night... I’m a recovering drug addict and a recovering alcoholic, but when I was taking drugs, there were a few nights where my blood turned into golden, beautiful sunshine. It was all chemical-based, and I knew it was a lie, but it was completely overwhelming, and it was like the sun had come out at night." Patrick changed the album title from "Gurney" to "The Sun Comes Out Tonight" after feeling so inspired