Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Nothing comes from nothing a relationship between Maria's theological acumen and this song is accidental or intentional. In the web television series "13 Reasons Why", Ryan Shaver uses this Latin phrase to show Hannah Baker, the main character, that her attempts to write poetry will be useless if she's not willing to put her soul on them, as she is afraid of expressing her most intimate thoughts with strangers. The phrase also appears in H.P. Lovecraft's tale, "The Whisperer in Darkness". Nothing comes from nothing Nothing comes from nothing () is a philosophical expression of a thesis first argued by Parmenides. It is associated