Drug discovery crude preparations are morphine, the active agent in opium, and digoxin, a heart stimulant originating from Digitalis lanata. Organic chemistry also led to the synthesis of many of the natural products isolated from biological sources. Historically, substances, whether crude extracts or purified chemicals, were screened for biological activity without knowledge of the biological target. Only after an active substance was identified was an effort made to identify the target. This approach is known as classical pharmacology, forward pharmacology, or phenotypic drug discovery. Later, small molecules were synthesized to specifically target a known physiological/pathological pathway, avoiding the mass screening of banks
Radioactive contamination from the Rocky Flats Plant of substantial contamination from the 1957 plutonium fire until after the highly visible 1969 fire, when civilian monitoring teams confronted government officials with measurements made outside the plant of radioactive contamination suspected to be from the 1969 fire, which consumed hundreds of pounds of plutonium (850 kg). The 1969 fire raised public awareness of potential hazards posed by the plant and led to years of increasing citizen protests and demands for plant closure. Releases from previous years had not been reported publicly prior to the fire; airborne-become-groundborne radioactive contamination extending well beyond the Rocky Flats plant was not publicly reported