The Ambassadors (Holbein) viewer must approach the painting from high on the right side, or low on the left side, to see the form as an accurate rendering of a human skull. While the skull is evidently intended as a "vanitas" or "memento mori", it is unclear why Holbein gave it such prominence in this painting. One possibility is that this painting represents three levels: the heavens (as portrayed by the astrolabe and other objects on the upper shelf), the living world (as evidenced by books and a musical instrument on the lower shelf), and death (signified by the skull). It has also
Hans Holbein the Elder the lead of the partnership and signed all the works they produced. After 1516 Holbein was declared a tax defaulter in Augsburg, which forced him to accept commissions abroad. At Issenheim in Alsace, where Matthias Grünewald was employed at the time, Holbein found patrons and was contracted to complete an altarpiece. His brother Sigismund and others sued him in Augsburg for unpaid debts. Pursued by Augsburg authorities, he fled Issenheim, abandoning his work and equipment, and went to Basel. He died two years later at an unknown location. After 1524 his name no longer appeared on the register of the