The Ambassadors (Holbein) been hypothesized that the painting is meant to hang in a stairwell, so that persons walking up the stairs and passing the painting on their left would be startled by the appearance of the skull. A further possibility is that Holbein simply wished to show off his ability with the technique in order to secure future commissions. Artists often incorporated skulls as a reminder of mortality. Holbein may have intended the skulls (one as a gray slash and the other as a medallion on Jean de Dinteville's hat) and the crucifix in the upper left corner to encourage contemplation of
Hans Holbein the Elder the lead of the partnership and signed all the works they produced. After 1516 Holbein was declared a tax defaulter in Augsburg, which forced him to accept commissions abroad. At Issenheim in Alsace, where Matthias Grünewald was employed at the time, Holbein found patrons and was contracted to complete an altarpiece. His brother Sigismund and others sued him in Augsburg for unpaid debts. Pursued by Augsburg authorities, he fled Issenheim, abandoning his work and equipment, and went to Basel. He died two years later at an unknown location. After 1524 his name no longer appeared on the register of the