Digitalis purpurea" extract containing cardiac glycosides for the treatment of heart conditions was first described in the English-speaking medical literature by William Withering, in 1785, which is considered the beginning of modern therapeutics. It is used to increase cardiac contractility (it is a positive inotrope) and as an antiarrhythmic agent to control the heart rate, particularly in the irregular (and often fast) atrial fibrillation. Digitalis is hence often prescribed for patients in atrial fibrillation, especially if they have been diagnosed with congestive heart failure. Digoxin was approved for heart failure in 1998 under current regulations by the Food and Drug Administration
The Sun Comes Out Tonight lyrics and album title was Patrick's prior issues with alcoholism and excessive drug use. Patrick explained it as: In my lifetime, the sun definitely came out at night... I’m a recovering drug addict and a recovering alcoholic, but when I was taking drugs, there were a few nights where my blood turned into golden, beautiful sunshine. It was all chemical-based, and I knew it was a lie, but it was completely overwhelming, and it was like the sun had come out at night." Patrick changed the album title from "Gurney" to "The Sun Comes Out Tonight" after feeling so inspired