Digitalis purpurea" extract containing cardiac glycosides for the treatment of heart conditions was first described in the English-speaking medical literature by William Withering, in 1785, which is considered the beginning of modern therapeutics. It is used to increase cardiac contractility (it is a positive inotrope) and as an antiarrhythmic agent to control the heart rate, particularly in the irregular (and often fast) atrial fibrillation. Digitalis is hence often prescribed for patients in atrial fibrillation, especially if they have been diagnosed with congestive heart failure. Digoxin was approved for heart failure in 1998 under current regulations by the Food and Drug Administration
Where Mathematics Comes From rethink a good deal of the philosophy of mind, epistemology, metaphysics, and the history of ideas. Where Mathematics Comes From Where Mathematics Comes From: How the Embodied Mind Brings Mathematics into Being (hereinafter "WMCF") is a book by George Lakoff, a cognitive linguist, and Rafael E. Núñez, a psychologist. Published in 2000, "WMCF" seeks to found a cognitive science of mathematics, a theory of embodied mathematics based on conceptual metaphor. Mathematics makes up that part of the human conceptual system that is special in the following way: Nikolay Lobachevsky said "There is no branch of mathematics, however abstract, which may