Istanbul in the 1970s, as people from Anatolia migrated to the city to find employment in the many new factories that were built on the outskirts of the sprawling metropolis. This sudden, sharp rise in the city's population caused a large demand for housing, and many previously outlying villages and forests became engulfed into the metropolitan area of Istanbul. Istanbul is located in north-western Turkey within the Marmara Region on a total area of . The Bosphorus, which connects the Sea of Marmara to the Black Sea, divides the city into a European, Thracian side—comprising the historic and economic centers—and an
Economy of Istanbul ITKIB: Pharmaceutical industry started in 1952 with the establishment of "Eczacıbaşı Pharmaceuticals Factory" in Levent, Istanbul. Today, 134 companies operate in the Turkish pharmaceutical industry, a significant part of which is based within or near Istanbul. Istanbul is one of the most important tourism spots of Turkey. There are thousands of hotels and other tourist oriented industries in the city, catering to both vacationers and visiting professionals. In 2006 a total of 23,148,669 tourists visited Turkey, most of whom entered the country through the airports and seaports of Istanbul and Antalya. The total number of tourists who entered Turkey through