Drug discovery crude preparations are morphine, the active agent in opium, and digoxin, a heart stimulant originating from Digitalis lanata. Organic chemistry also led to the synthesis of many of the natural products isolated from biological sources. Historically, substances, whether crude extracts or purified chemicals, were screened for biological activity without knowledge of the biological target. Only after an active substance was identified was an effort made to identify the target. This approach is known as classical pharmacology, forward pharmacology, or phenotypic drug discovery. Later, small molecules were synthesized to specifically target a known physiological/pathological pathway, avoiding the mass screening of banks
Until She Comes Until She Comes "Until She Comes" is a 1991 song by the English rock band the Psychedelic Furs, taken from their seventh studio album, "World Outside". Written by the Psychedelic Furs and produced by the band with Stephen Street, it was released in June as the album's first single. The 12" version included a remix by Hugh Padgham. The lyrics of "Until She Comes" depict a metaphorical story about drug addiction. The single spent two weeks at No. 1 on the US Modern Rock Tracks chart in September 1991. Author Dave Thompson described the song as "bittersweet" and reminiscent of