Drug discovery crude preparations are morphine, the active agent in opium, and digoxin, a heart stimulant originating from Digitalis lanata. Organic chemistry also led to the synthesis of many of the natural products isolated from biological sources. Historically, substances, whether crude extracts or purified chemicals, were screened for biological activity without knowledge of the biological target. Only after an active substance was identified was an effort made to identify the target. This approach is known as classical pharmacology, forward pharmacology, or phenotypic drug discovery. Later, small molecules were synthesized to specifically target a known physiological/pathological pathway, avoiding the mass screening of banks
The Sun Comes Out Tonight lyrics and album title was Patrick's prior issues with alcoholism and excessive drug use. Patrick explained it as: In my lifetime, the sun definitely came out at night... I’m a recovering drug addict and a recovering alcoholic, but when I was taking drugs, there were a few nights where my blood turned into golden, beautiful sunshine. It was all chemical-based, and I knew it was a lie, but it was completely overwhelming, and it was like the sun had come out at night." Patrick changed the album title from "Gurney" to "The Sun Comes Out Tonight" after feeling so inspired