Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Mountaineer Power Plant that coal now comes via barge on the Ohio River to an elaborate coal unloading and storage facility.The other portion of coal comes from Big River Mining. An underground coal mine right across the street from the plant. It is mined, cleaned, processed, and shipped by a belt line across the street to the power plant. This single boiler, dual turbine plant produces enough energy to power a city approximately the size of Columbus, Ohio. The plant is connected to the grid by 765 kilovolt transmission lines (the highest rated voltage used in the United States). The location of the