Digitalis purpurea" extract containing cardiac glycosides for the treatment of heart conditions was first described in the English-speaking medical literature by William Withering, in 1785, which is considered the beginning of modern therapeutics. It is used to increase cardiac contractility (it is a positive inotrope) and as an antiarrhythmic agent to control the heart rate, particularly in the irregular (and often fast) atrial fibrillation. Digitalis is hence often prescribed for patients in atrial fibrillation, especially if they have been diagnosed with congestive heart failure. Digoxin was approved for heart failure in 1998 under current regulations by the Food and Drug Administration
Drug pollution Drug pollution Drug pollution or pharmaceutical pollution is pollution of the environment with pharmaceutical drugs and their metabolites, which reach the aquatic environment (groundwater, rivers, lakes, and oceans) through wastewater. Drug pollution is therefore mainly a form of water pollution. "Pharmaceutical pollution is now detected in waters throughout the world," said a scientist at the Cary Institute of Ecosystem Studies in Millbrook, New York. "Causes include aging infrastructure, sewage overflows and agricultural runoff. Even when wastewater makes it to sewage treatment facilities, they aren't equipped to remove pharmaceuticals." Most such pollution comes simply from the drugs having been cleared and