Digitalis purpurea" extract containing cardiac glycosides for the treatment of heart conditions was first described in the English-speaking medical literature by William Withering, in 1785, which is considered the beginning of modern therapeutics. It is used to increase cardiac contractility (it is a positive inotrope) and as an antiarrhythmic agent to control the heart rate, particularly in the irregular (and often fast) atrial fibrillation. Digitalis is hence often prescribed for patients in atrial fibrillation, especially if they have been diagnosed with congestive heart failure. Digoxin was approved for heart failure in 1998 under current regulations by the Food and Drug Administration
Radioactive contamination from the Rocky Flats Plant of substantial contamination from the 1957 plutonium fire until after the highly visible 1969 fire, when civilian monitoring teams confronted government officials with measurements made outside the plant of radioactive contamination suspected to be from the 1969 fire, which consumed hundreds of pounds of plutonium (850 kg). The 1969 fire raised public awareness of potential hazards posed by the plant and led to years of increasing citizen protests and demands for plant closure. Releases from previous years had not been reported publicly prior to the fire; airborne-become-groundborne radioactive contamination extending well beyond the Rocky Flats plant was not publicly reported