Digitalis digitalis. As a result of increased contractility, stroke volume is increased. Ultimately, digitalis increases cardiac output (Cardiac Output=Stroke Volume x Heart Rate). This is the mechanism that makes this drug a popular treatment for congestive heart failure, which is characterized by low cardiac output. Digitalis also has a vagal effect on the parasympathetic nervous system, and as such is used in re-entrant cardiac arrhythmias and to slow the ventricular rate during atrial fibrillation. The dependence on the vagal effect means digitalis is not effective when a patient has a high sympathetic nervous system drive, which is the case with acutely
Orazio Comes experimentation in that sector. In 1958 the museum of the botanical institute of Portici, hosted in the Royal Palace, was named after him. Orazio Comes Orazio Comes (11 November 1848 – 13 October 1917) was an Italian botanist. From 1906 to 1917 he directed the Agricultural Higher Institute of Portici, in which, thanks to Vincenzo de Cesati, he begun teaching since 1877 as assistant of Nicola Pedicino for the chair of botany, to whom he succeeded in 1880. In his works he studied the physiology and plant pathology of Neapolitan mushrooms and agricultural plants, such as beans and tobacco. From