Mexican beaded lizard debate among scientists. However, this venom has been found to contain several enzymes useful for manufacturing drugs in the treatment of diabetes, and research on the pharmacological use of its venom is ongoing. Threatened throughout its range by overcollection and habitat loss, it is a CITES protected species. The Guatemalan beaded lizard ("H. charlesbogerti" ) is one of the rarest lizards in the world, with a wild population of fewer than 200. The beaded lizards have one close living relative, the Gila monster ("H. suspectum"), as well as many extinct relatives in the Helodermatidae, whose genetic history may be traced
Philippine sailfin lizard sailfin lizards were commonly available in the United States during the 1990s, but today they are now rare and expensive in the United States (costing about $650 for a captive bred juvenile). Breeding in captivity has only been done in a few cases. But because it is common in many parts of the Philippines, the pet trade in many regions still continues and some are even unrecognized by the government. Philippine sailfin lizard The Philippine sailfin lizard, crested lizard, sail-fin lizard, sailfin water lizard, soa-soa water lizard (Hydrosaurus pustulatus) or its native name "ibid" is an oviparous lizard living only