Mexican beaded lizard generic name "Heloderma" means "studded skin", from the Ancient Greek words "hêlos" (ἧλος)—the head of a nail or stud—and "dérma" (δέρμα), meaning skin. Its specific name, "horrĭdum", is the Latin word meaning rough or rude. The four subspecies of beaded lizard, elevated to full species in 2013, are: Adult beaded lizards range from in length. They are substantially larger than the Gila monster, which only reaches lengths of . The snout-to-vent length of a beaded lizard averages . The average body mass of an adult beaded lizard is , about 45% heavier than the average mass of a gila monster,
Mexican beaded lizard is listed on Appendix II of CITES. Fewer than 200 lizards remain in the dry forest habitat of the Motagua Valley, and this species of beaded lizard ("H. charlesbogerti") was facing extinction due to local extermination and loss of habitat for agricultural purposes. A conservation effort has been launched known as Project Heloderma to preserve the semiarid habitat of the Motagua Valley by the Nature Conservancy and partners such as ZOOTROPIC, CONAP, the International Reptile Conservation Foundation, Lincoln Park Zoo, Zoo Atlanta, and the San Diego Zoo. This effort has been successful in getting the Guatemalan government to list the