Pertussis vaccine contain reduced amounts of pertussis antigens compared to DTaP vaccines. Pearl Kendrick and Grace Eldering studied pertussis in the 1930s. They developed and ran the first large scale study of a successful vaccine for the disease. During the 1970s and 1980s, a controversy erupted related to the question of whether the whole-cell pertussis component caused permanent brain injury in rare cases, called pertussis vaccine encephalopathy. Despite this allegation, doctors recommended the vaccine due to the overwhelming public health benefit, because the claimed rate was very low (one case per 310,000 immunizations, or about 50 cases out of the 15 million
Darier's disease Darier's disease Darier's disease (DAR), also known as Darier disease, Darier–White disease, Dyskeratosis follicularis, and Keratosis follicularis, is an autosomal dominant disorder discovered by French dermatologist Ferdinand-Jean Darier. Darier's is characterized by dark crusty patches on the skin, sometimes containing pus. The crusty patches are also known as keratotic papules, keratosis follicularis, or dyskeratosis follicularis. Mild forms of the disease are the most common, consisting solely of skin rashes that flare up under certain conditions such as high humidity, high stress, or tight-fitting clothes. Short stature, when combined with poorly-formed fingernails that contain vertical striations, is diagnostic even for mild