Pertussis toxin is an equilibrium between the folded and unfolded states. When the protein is unfolded, it is susceptible to degradation by the 20S proteasome, which can degrade only unfolded proteins. Pertussis toxin Pertussis toxin (PT) is a protein-based AB-type exotoxin produced by the bacterium "Bordetella pertussis", which causes whooping cough. PT is involved in the colonization of the respiratory tract and the establishment of infection. Research suggests PT may have a therapeutic role in treating a number of common human ailments, including hypertension, viral inhibition, and autoimmune inhibition. PT clearly plays a central role in the pathogenesis of pertussis although this
Binswanger's disease history of Binswanger's disease and the fact that it was overlooked as a disease for many years means many patients may have been misdiagnosed with Alzheimer's disease. Binswanger's disease Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy (SAE), is a form of small vessel vascular dementia caused by damage to the white brain matter. White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age. This disease is characterized by loss of memory and intellectual function and by changes in mood. These changes encompass what are known as executive functions of