Bordetella parapertussis evolved in a host population that had already developed immunity to "B. pertussis", where being able to evade "B. pertussis" immunity was an advantage. Two lineages of "B. parapertussis" have been described. The first infects humans and is responsible for a minority of cases of the disease pertussis (also known as whooping cough). The second, ovine, lineage causes chronic nonprogressive pneumonia in sheep. Both lineages are thought to have evolved from a "B. bronchiseptica"-like ancestor. This disease can be symptomatic or asymptomatic and may predispose hosts to secondary infection. Bordetella parapertussis Bordetella parapertussis is a small Gram-negative bacterium of the
Schindler disease Schindler disease Schindler disease, also known as Kanzaki disease and alpha-N-acetylgalactosaminidase deficiency is a rare disease found in humans. This lysosomal storage disorder is caused by a deficiency in the enzyme alpha-NAGA (alpha-N-acetylgalactosaminidase), attributable to mutations in the NAGA gene on chromosome 22, which leads to excessive lysosomal accumulation of glycoproteins. A deficiency of the alpha-NAGA enzyme leads to an accumulation of glycosphingolipids throughout the body. This accumulation of sugars gives rise to the clinical features associated with this disorder. Schindler disease is an autosomal recessive disorder, meaning that one must inherit an abnormal allele from both parents in order