Pertussis toxin "Bordetella" is that "B. pertussis" produces PT and the other species do not. "Bordetella parapertussis" shows the most similarity to "B. pertussis" and was therefore used for research determining the role of PT in causing the typical symptoms of whooping cough. Rat studies showed the development of paroxysmal coughing, a characteristic for whooping cough, occurred in rats infected with "B. pertussis". Rats infected with "B. parapertussis" or a PT-deficient mutant of "B. pertussis" did not show this symptom; neither of these two strains produced PT. A large group of bacterial exotoxins are referred to as "A/B toxins", in essence because
Degos disease Degos disease Degos disease, also known as Köhlmeier-Degos disease or malignant atrophic papulosis (MAP), is an extremely rare condition caused by blockage of arteries and veins. Individuals with this condition will develop papules. Those diagnosed with this disease may also develop complications due to impairment of internal organs. The exact underlying mechanism is still unknown, and an effective treatment is still being developed. There are fewer than 50 living patients presently known worldwide, and fewer than 200 reported in medical literature. However, it is important to note that many individuals may go undiagnosed due to rarity of the disease. Most