Pertussis toxin "Bordetella" is that "B. pertussis" produces PT and the other species do not. "Bordetella parapertussis" shows the most similarity to "B. pertussis" and was therefore used for research determining the role of PT in causing the typical symptoms of whooping cough. Rat studies showed the development of paroxysmal coughing, a characteristic for whooping cough, occurred in rats infected with "B. pertussis". Rats infected with "B. parapertussis" or a PT-deficient mutant of "B. pertussis" did not show this symptom; neither of these two strains produced PT. A large group of bacterial exotoxins are referred to as "A/B toxins", in essence because
Pick's disease in neuronal tissue—is named a Pick body. In 1911, Alois Alzheimer noted the complete absence of senile plaques and neurofilbrillary tangles as well as the presence of Pick bodies and occasional ballooned neurons. Pick's disease Pick's disease is a specific pathology that is one of the causes of frontotemporal lobar degeneration. It is also known as Pick disease and PiD (not to be confused with pelvic inflammatory disease (PID) or Parkinson's disease (PD)). A defining characteristic of the disease is build-up of tau proteins in neurons, accumulating into silver-staining, spherical aggregations known as "Pick bodies". Common symptoms that are noticed