Pertussis toxin that encode Ptl proteins. Together, these proteins form the PT secretion complex. PT is released from "B. pertussis" in an inactive form. Following PT binding to a cell membrane receptor, it is taken up in an endosome, after which it undergoes retrograde transport to the trans-Golgi network and endoplasmic reticulum. At some point during this transport, the A subunit (or protomer) becomes activated, perhaps through the action of glutathione and ATP. PT catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric G protein. This prevents the G proteins from interacting with G protein-coupled receptors on the cell membrane, thus
Aleutian disease from other ferrets. All items that may have come into contact with the infected ferret should be cleaned with a 10% bleach solution. This is a growing concern within mink producers as it is the most crucial infectious disease which affects farmed mink worldwide. Aleutian disease Aleutian disease, also known as mink plasmacytosis, is a disease which causes spontaneous abortion and death in minks and ferrets. It is caused by "Carnivore amdoparvovirus 1" (also known as "Aleution disease virus", ADV), a highly contagious parvovirus in the genus "Amdoparvovirus". The virus has been found as a natural infection in the "Mustelidae"