Pertussis toxin they are formed from two subunits. The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit. Pertussis toxin is an exotoxin with six subunits (named "S1" through "S5"—each complex contains two copies of "S4"). The subunits are arranged in "A-B" structure: the "A" component is enzymatically active and is formed from the S1 subunit, while the "B" component is the receptor-binding portion and is made up of subunits S2–S5. The subunits are encoded by "ptx" genes encoded on a large PT operon that also includes additional genes
Mondor's disease Mondor's disease Mondor's disease (also known as "Mondor's syndrome of superficial thrombophlebitis") is a rare condition which involves thrombophlebitis of the superficial veins of the breast and anterior chest wall. It sometimes occurs in the arm or penis. In axilla, this condition is known as axillary web syndrome. Patients with this disease often have abrupt onset of superficial pain, with possible swelling and redness of a limited area of their anterior chest wall or breast. There is usually a lump present, which may be somewhat linear and tender. Because of the possibility of the lump being from another cause, patients