Pertussis vaccine contain reduced amounts of pertussis antigens compared to DTaP vaccines. Pearl Kendrick and Grace Eldering studied pertussis in the 1930s. They developed and ran the first large scale study of a successful vaccine for the disease. During the 1970s and 1980s, a controversy erupted related to the question of whether the whole-cell pertussis component caused permanent brain injury in rare cases, called pertussis vaccine encephalopathy. Despite this allegation, doctors recommended the vaccine due to the overwhelming public health benefit, because the claimed rate was very low (one case per 310,000 immunizations, or about 50 cases out of the 15 million
Blount's disease Blount's disease Blount's disease is a growth disorder of the tibia (shin bone) that causes the lower leg to angle inward, resembling a bowleg. It is also known as "tibia vara". It is named after Walter Putnam Blount (1900–1992), an American pediatric orthopedic surgeon. It has also been known as Mau-Nilsonne Syndrome, after C. Mau and H. Nilsonne, who published early case reports of the condition. Bowing of one or both legs that may: Failure to treat Blount's disease may lead to progressive deformity.Blount's disease may come back after surgery, especially in younger children. Because of the bowing, a leg-length