Margaret of Anjou Margaret of Anjou Margaret of Anjou (; 23 March 1430 – 25 August 1482) was the Queen of England by marriage to King Henry VI from 1445 to 1461 and again from 1470 to 1471. Born in the Duchy of Lorraine into the House of Valois-Anjou, Margaret was the second eldest daughter of René, King of Naples, and Isabella, Duchess of Lorraine. She was one of the principal figures in the series of dynastic civil wars known as the Wars of the Roses and at times personally led the Lancastrian faction. Owing to her husband's frequent bouts of insanity, Margaret
Black Death in England to recover, since it disproportionately affected infants and young men. This was also the case with the next occurrence, in 1369, where the death rate was around 10−15 percent. Over the following decades the plague would return on a national or a regional level at intervals of five to 12 years, with gradually dwindling death tolls. Then, in the decades from 1430 to 1480, the disease returned in force. An outbreak in 1471 took as much as 10–15 percent of the population, while the death rate of the plague of 1479–80 could have been as high as 20 percent. From