Pertussis toxin other lung cells produce a variety of chemokines. PT has been found to inhibit the early transcription of keratinocyte-derived chemokine, macrophage inflammatory protein 2 and LPS-induced CXC chemokine. Eventually, PT causes lymphocytosis, one of the systemic manifestations of whooping cough. PT, a decisive virulence determinant of "B. pertussis", is able to cross the blood–brain barrier by increasing its permeability. As a result, PT can cause severe neurological complications; however, recently it has been found that the medicinal usage of "Pertussis" toxin can promote the development of regulatory T cells and prevent central nervous system autoimmune disease, such as multiple sclerosis.
White line disease wall resection or debridement. Sometimes, if the problem is severe enough, the horse may need to be specially shod with a heart-bar shoe. White line disease White line disease (also known as seedy toe) is a fungal infection of the horse's hoof. As the name suggests, it attacks the white line, which connects the sole to the hoof wall. It is sometimes mistaken for hoof wall separation disease, but is not to be confused because it is not genetic nor as severe. White line disease changes the typical light color of the white line to a black or dark gray