Bordetella pertussis Bordetella pertussis Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus "Bordetella", and the causative agent of pertussis or whooping cough. Unlike "B. bronchiseptica", "B. pertussis" is not motile. Its virulence factors include pertussis toxin, filamentous hæmagglutinin, pertactin, fimbria, and tracheal cytotoxin. The bacterium is spread by airborne droplets; its incubation period is 9–10 days on average (range 6–20 days). Humans are the only known reservoir for "B. pertussis". The complete "B. pertussis" genome of 4,086,186 base pairs was published in 2003. Pertussis is an infection of the respiratory system characterized by a “whooping” sound when the
Wilson disease protein Wilson disease protein Wilson disease protein (WND), also known as ATP7B protein, is a copper-transporting P-type ATPase which is encoded by the "ATP7B" gene. The ATP7B protein is located in the trans-Golgi network of the liver and brain and balances the copper level in the body by excreting excess copper into bile and plasma. Genetic disorder of the ATP7B gene may cause Wilson's disease, a disease in which copper accumulates in tissues, leading to neurological or psychiatric issues and liver diseases. Wilson disease protein is associated with "ATP7B" gene,approximate 80 Kb, located on human chromosome 13 and consists of 21