Pertussis toxin that encode Ptl proteins. Together, these proteins form the PT secretion complex. PT is released from "B. pertussis" in an inactive form. Following PT binding to a cell membrane receptor, it is taken up in an endosome, after which it undergoes retrograde transport to the trans-Golgi network and endoplasmic reticulum. At some point during this transport, the A subunit (or protomer) becomes activated, perhaps through the action of glutathione and ATP. PT catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric G protein. This prevents the G proteins from interacting with G protein-coupled receptors on the cell membrane, thus
Byne's disease high humidity can also affect pyrite (or its more reactive polymorph marcasite) (iron sulphide) fossils in a somewhat similar condition, which is known as pyrite disease. The iron sulfide can react with water and oxygen to form iron sulfates and sulfuric acid, which then can produce Bynesian decay. Byne's disease Byne's disease, more accurately known as Bynesian decay, is a peculiar and permanently damaging condition (resulting from an ongoing chemical reaction) which often attacks mollusk shells that are in storage or on display for long periods of time. Bynesian decay is a form of efflorescence of salts formed by the