Pertussis toxin they are formed from two subunits. The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit. Pertussis toxin is an exotoxin with six subunits (named "S1" through "S5"—each complex contains two copies of "S4"). The subunits are arranged in "A-B" structure: the "A" component is enzymatically active and is formed from the S1 subunit, while the "B" component is the receptor-binding portion and is made up of subunits S2–S5. The subunits are encoded by "ptx" genes encoded on a large PT operon that also includes additional genes
Aleutian disease Aleutian disease Aleutian disease, also known as mink plasmacytosis, is a disease which causes spontaneous abortion and death in minks and ferrets. It is caused by "Carnivore amdoparvovirus 1" (also known as "Aleution disease virus", ADV), a highly contagious parvovirus in the genus "Amdoparvovirus". The virus has been found as a natural infection in the "Mustelidae" family within mink, ferrets, otters, polecats, stone and pine martens and within other varying carnivores such as skunks, genets, foxes and raccoons. This is most commonly explained as because they all share resources and habitats. Aleutian Disease was first recognized in ranch-raised mink in