Pertussis toxin of an outbreak in Paris in 1414. This was published in Moulton’s The Mirror of Health, in 1640. Another epidemic of pertussis took place in Paris in 1578 and was described by a contemporary observer, Guillaume de Baillou. Pertussis was well known throughout Europe by the middle of the 18th century. Jules Bordet and Octave Gengou described in 1900 the finding of a new “ovoid bacillus” in the sputum of a 6-month-old infant with whooping cough. They were also the first to cultivate "Bordetella pertussis" at the Pasteur Institute in Brussels in 1906. One difference between the different species of
White line disease White line disease White line disease (also known as seedy toe) is a fungal infection of the horse's hoof. As the name suggests, it attacks the white line, which connects the sole to the hoof wall. It is sometimes mistaken for hoof wall separation disease, but is not to be confused because it is not genetic nor as severe. White line disease changes the typical light color of the white line to a black or dark gray color. It may also give off a foul odor. Lameness is often not present unless the disease is advanced. The disease may locate