Whooping cough Sato developed an acellular vaccine consisting of purified haemagglutinins (HAs: filamentous strep throat and leukocytosis-promoting-factor HA), which are secreted by "B. pertussis". Sato's acellular pertussis vaccine was used in Japan starting in 1981. Later versions of the acellular vaccine in other countries consisted of additional defined components of "B. pertussis" and were often part of the DTaP combination vaccine. Whooping cough Whooping cough (also known as pertussis or 100-day cough) is a highly contagious bacterial disease. Initially, symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough. This is followed by weeks
Riggs' disease Riggs' disease Riggs' disease, also known as pyorrhea of a toothsocket or gingivitis expulsiva, is a historical term for periodontitis (gum disease), The condition was described as a purulent inflammation of the dental periosteum. It was named after American dentist John Mankey Riggs (1811–1885). Riggs' disease was said to produce the progressive necrosis of the alveoli and looseness of the teeth. The teeth may become very loose and fall out of the sockets. Mark Twain wrote briefly about Riggs' disease in his short essay, "Happy Memories of the Dental Chair", in which he claims to have been examined by Dr.