Mexican beaded lizard debate among scientists. However, this venom has been found to contain several enzymes useful for manufacturing drugs in the treatment of diabetes, and research on the pharmacological use of its venom is ongoing. Threatened throughout its range by overcollection and habitat loss, it is a CITES protected species. The Guatemalan beaded lizard ("H. charlesbogerti" ) is one of the rarest lizards in the world, with a wild population of fewer than 200. The beaded lizards have one close living relative, the Gila monster ("H. suspectum"), as well as many extinct relatives in the Helodermatidae, whose genetic history may be traced
Mexican beaded lizard back to the Cretaceous period. The genus "Heloderma" has existed since the Miocene, when "H. texana" ranged over most of North America. Because the helodermatids have remained relatively unchanged morphologically, they are occasionally regarded as living fossils. Although the beaded lizard appears closely related to the monitor lizards (varanids) of Africa, Asia, and Australia, the wide geographical separation and unique features not found in the varanids indicate the beaded lizard is better placed in a separate family. The species was first described in 1829 by Arend Wiegmann as "Trachyderma horridum", but he renamed it "Heloderma horridum" six months later. Its