Bordetella parapertussis evolved in a host population that had already developed immunity to "B. pertussis", where being able to evade "B. pertussis" immunity was an advantage. Two lineages of "B. parapertussis" have been described. The first infects humans and is responsible for a minority of cases of the disease pertussis (also known as whooping cough). The second, ovine, lineage causes chronic nonprogressive pneumonia in sheep. Both lineages are thought to have evolved from a "B. bronchiseptica"-like ancestor. This disease can be symptomatic or asymptomatic and may predispose hosts to secondary infection. Bordetella parapertussis Bordetella parapertussis is a small Gram-negative bacterium of the
Gaucher's disease May 1994 and has replaced the use of Ceredase. October is National Gaucher's Disease Awareness Month in the United States. Gaucher's disease Gaucher's disease or Gaucher disease () (GD) is a genetic disorder in which glucocerebroside (a sphingolipid, also known as glucosylceramide) accumulates in cells and certain organs. The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the enzyme glucocerebrosidase (also known as glucosylceramidase), which acts on glucocerebroside. When the enzyme is defective, glucocerebroside accumulates, particularly in white blood cells and especially