Bombyx mori silkworms for the production of raw silk, has been under way for at least 5,000 years in China, from where it spread to India, Korea, Japan, and the West. The silkworm was domesticated from the wild silkmoth "Bombyx mandarina", which has a range from northern India to northern China, Korea, Japan, and the far eastern regions of Russia. The domesticated silkworm derives from Chinese rather than Japanese or Korean stock. Silkworms were unlikely to have been domestically bred before the Neolithic age. Before then, the tools to manufacture quantities of silk thread had not been developed. The domesticated "B. mori"
Bombyx mandarina differ in karyotype from those of inland China. Domestic silkmoths are closer to the latter regarding mtDNA sequence data, and especially lack some genetic apomorphies of the northeastern "B. mandarina". Thus, the initial domestic stock came from inland China. "B. mandarina" is able to hybridize with "B. mori". Both in the wild and in a domesticated environment, females release pheromones and wait for males to be attracted and fly to them. However, "B. mori" males cannot fly. Hybridisation in the wild, therefore, inevitably means breeding between domestic ("B. mori") females and wild ("B. mandarina") males. Hybridization is possible in both