The Adventures of Sherlock Holmes (film) Rathbone as Sherlock Holmes and Nigel Bruce as Dr. John Watson, the final film produced by Fox, and the last in the Rathbone/Bruce series to be set in the original Victorian London period. The further twelve films produced by Universal Pictures and starring Rathbone/Bruce would take place in contemporaneous times (i.e. the 1940s). George Zucco stars as Holmes's nemesis Professor Moriarty. The picture follows famous detective Sherlock Holmes and his assistant Doctor Watson as they attempt to foil their archenemy Professor Moriarty who targets a wealthy family and plots the theft of the Crown Jewels. The film was supposedly based
Holmes & Watson Sherlock Holmes and Dr. John Watson as they use their brilliant minds to stop rival Professor James Moriarty from assassinating the Queen Victoria. In July 2008, it was reported that Sacha Baron Cohen would play Holmes and Will Ferrell would play Dr. Watson, in a comedic take on Sherlock Holmes produced by Judd Apatow with a script written by Etan Cohen for Columbia Pictures. On August 17, 2016, it was reported that Ferrell and John C. Reilly would star in the film "Holmes and Watson" written and directed by Etan Cohen, with Ferrell playing Holmes and Reilly playing Watson. On