Felix Hoffmann Felix Hoffmann Felix Hoffmann (21 January 1868 – 8 February 1946) was a German chemist notable for re-synthesizing diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin". He is also credited with synthesizing aspirin, though whether he did this under his own initiative or under the instruction of Arthur Eichengrün is contested. Felix Hoffmann was born on 21 January 1868 in Ludwigsburg, Germany, the son of an industrialist. In 1889 he started studying chemistry at the Ludwig Maximilian University of Munich to study pharmacy and ended it
Drug delivery to the brain permeability was known and labeled them either CNS+ or CNS- for compounds that easily transverse the barrier and those that did not. They then set out to analyze the above factors to determine what is necessary to transverse the blood–brain barrier. What they found was a little surprising; lipophilicity is not the leading characteristic for a drug to pass through the barrier. This is surprising because one would think that the most effective way to make a drug move through a lipophilic barrier is to increase its lipophilicity, it turns out that it is a complex function of all of