Bombyx mori silkworms for the production of raw silk, has been under way for at least 5,000 years in China, from where it spread to India, Korea, Japan, and the West. The silkworm was domesticated from the wild silkmoth "Bombyx mandarina", which has a range from northern India to northern China, Korea, Japan, and the far eastern regions of Russia. The domesticated silkworm derives from Chinese rather than Japanese or Korean stock. Silkworms were unlikely to have been domestically bred before the Neolithic age. Before then, the tools to manufacture quantities of silk thread had not been developed. The domesticated "B. mori"
Serratiopeptidase Serratiopeptidase Serratiopeptidase (Serratia E-15 protease, also known as serralysin, serrapeptase, serratiapeptase, serratia peptidase, serratio peptidase, or serrapeptidase) is a proteolytic enzyme (protease) produced by non-pathogenic enterobacterium "Serratia" sp. E-15. This microorganism was originally isolated in the late 1960s from silkworm "Bombyx mori" L. (intestine), Serratiopeptidase is present in the silkworm intestine and allows the emerging moth to dissolve its cocoon. Serratiopeptase is produced by purification from culture of Serratia E-15 bacteria. Some alternative medicine proponents claim that serratiopeptidase is beneficial for pain and inflammation but "existing trials [have been] small and generally of poor methodological quality." Online medical journal "Bandolier"