The Tenant of Wildfell Hall the book title acted out by Lady Mary Crawley in the Christmas charade. The story of Helen Graham is mentioned in Elizabeth George's 1988 novel "A Great Deliverance". Her name is also used as a secret code. Tina Connolly's 2013 novel "Copperhead" was inspired by "The Tenant of Wildfell Hall". The name of the heroine is Helen Huntingdon and she also has a disastrous marriage. Sam Baker's 2016 novel "The Woman Who Ran" takes inspiration from radical themes of Anne's novel. The heroine is a woman also called Helen, who she hides from her past (in an abusive marriage) in
Diseases and epidemics of the 19th century and Robert Koch's discovery of micro-organisms as the cause of disease transmission. Thus throughout the majority of the 19th century, there was only the most basic, common sense understanding of the causes, amelioration and treatment of epidemic disease. The late 19th century was the beginning of widespread use of vaccines. The cholera bacterium was isolated in 1854 by Italian anatomist Filippo Pacini, and a vaccine, the first to immunize humans against a bacterial disease, was developed by Spanish physician Jaume Ferran i Clua in 1885, and by Russian-Jewish bacteriologist Waldemar Haffkine in July 1892. Antibiotic drugs did not appear until