Silk remarkable mechanical properties, comparative biocompatibility, tunable degradation rates "in vitro" and "in vivo", the ease to load cellular growth factors (for example, BMP-2), and the ability to be processed into several other formats such as films, gels, particles, and scaffolds. Silks from "Bombyx mori", a kind of cultivated silkworm, are the most widely investigated silks. Silks derived from "Bombyx mori" are generally made of two parts: the silk fibroin fiber which contains a light chain of 25kDa and a heavy chain of 350kDa (or 390kDa) linked by a single disulfide bond and a glue-like protein, sericin, comprising 25 to 30
Bombyx mori and the wild "B. mandarina" can still breed and sometimes produce hybrids. Domestic silkmoths are very different from most members in the genus "Bombyx"; not only have they lost the ability to fly, but their color pigments are also lost. Mulberry silkworms can be categorized into three different but connected groups or types. The major groups of silkworms fall under the univoltine ("uni-"=one, "voltine"=brood frequency) and bivoltine categories. The univoltine breed is generally linked with the geographical area within greater Europe. The eggs of this type hibernate during winter due to the cold climate, and cross-fertilize only by spring, generating