Two-hybrid screening developed in a silkworm cell line from the larva or caterpillar of the domesticated silk moth, "Bombyx mori" (BmN4 cells). This system uses the GAL4 BD and the activation domain of mouse NF-κB P65. Both are under the control of the OpIE2 promoter. By changing specific amino acids by mutating the corresponding DNA base-pairs in the plasmids used, the importance of those amino acid residues in maintaining the interaction can be determined. After using bacterial cell-based method to select DNA-binding proteins, it is necessary to check the specificity of these domains as there is a limit to the extent to
The Silkworm to stage his disappearance, rewrote "Bombyx Mori", killed Quine and framed Leonora for the crime. Tassel attempts to flee the party only to be quickly caught and arrested, which Strike and Robin planned in advance. Sometime later, Leonora is released from prison, Fancourt acknowledges the original "Bombyx Mori" manuscript's literary value, and Strike tells Robin that he enrolled her in investigative training courses as a Christmas gift. Much like "The Cuckoo's Calling", "The Silkworm" was met with critical acclaim, selling more copies than its predecessor in its opening weeks. Val McDermid from "The Guardian" gave the novel a positive review,