Felix Hoffmann to investigate the substance's efficacy and tolerability had been completed, it was found to be an analgesic, antipyretic and antiinflammatory substance. The company then worked to develop a cost-effective production process that would facilitate the promising active ingredient to be supplied as a pharmaceutical product. In 1899 it was marketed for the first time under the trade name "Aspirin", initially as a powder supplied in glass bottles. He also synthesized diamorphine (heroin), previously achieved by Charles Romley Alder Wright. Following the synthesis of aspirin, Hoffmann moved to the pharmaceutical marketing department where he stayed until his retirement in 1928. He
Illegal drug trade in Guatemala may be due, at least in part, to the relationship between Los Zetas and the Guatemalan Kaibiles. Beyond the apparently more-established Zeta smuggling operations there, several recent drug seizures — including an enormous 1,800-acre poppy plantation attributed to the Sinaloa cartel — make it clear that other Mexican drug-trafficking organizations are currently active inside Guatemala." Illegal drug trade in Guatemala The illegal drug trade in Guatemala includes trans-shipment of cocaine to the United States. According to some reports, Mexican drug cartels such as Sinaloa have also established poppy growing operations there. There is a reported relationship between the Mexican Los