Bombyx mori the molecular identification of the first known pheromone, bombykol, which required extracts from 500,000 individuals, due to the very small quantities of pheromone produced by any individual worm. Currently, research is focusing on genetics of silkworms and the possibility of genetic engineering. Many hundreds of strains are maintained, and over 400 Mendelian mutations have been described. Another source suggests 1,000 inbred domesticated strains are kept worldwide. One useful development for the silk industry is silkworms that can feed on food other than mulberry leaves, including an artificial diet. Research on the genome also raises the possibility of genetically engineering silkworms
Bombyx mandarina differ in karyotype from those of inland China. Domestic silkmoths are closer to the latter regarding mtDNA sequence data, and especially lack some genetic apomorphies of the northeastern "B. mandarina". Thus, the initial domestic stock came from inland China. "B. mandarina" is able to hybridize with "B. mori". Both in the wild and in a domesticated environment, females release pheromones and wait for males to be attracted and fly to them. However, "B. mori" males cannot fly. Hybridisation in the wild, therefore, inevitably means breeding between domestic ("B. mori") females and wild ("B. mandarina") males. Hybridization is possible in both