Fear of mice of both in vivo and in vitro desensitization during treatment. It is also helpful to encourage patients to experience some positive associations with mice: thus, the feared stimulus is paired with the positive rather than being continuously reinforced by the negative. An exaggerated, phobic fear of mice and rats has traditionally been depicted as a stereotypical trait of women, with numerous books, cartoons, television shows, and films portraying women screaming and jumping onto chairs or tables at the sight of a mouse – for example, Mammy Two Shoes in "Tom and Jerry". Despite the gender-stereotype portrayal Western murophobia has always
Abnormal cannabidiol Abnormal cannabidiol Abnormal cannabidiol (Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive effects. It has been shown that the actions of abnormal cannabidiol are mediated through a site separate from the CB and CB receptors, which responds to abnormal cannabidiol, O-1602, and the endogenous ligands: anandamide (AEA), N-arachidonoyl glycine (NAGly) and N-arachidonoyl L-serine. Multiple lines of evidence support the proposed identification of this novel target in microglia as the previously "orphan" receptor