Calamine the World Health Organization's List of Essential Medicines for being one of the most effective and safe medicines needed in a health system. Calamine is available over the counter as a generic medication. The wholesale cost in the developing world is about US$0.25–3.85 per 100-ml bottle. In the United Kingdom, it costs the National Health Service about £0.44. Calamine is used to treat itchiness. This includes from sunburn, insect bite, or other mild skin conditions. Calamine is mixed with either zinc oxide (ZnO) with about 0.5% ferric oxide (FeO) or a zinc carbonate compound. Calamine lotion is a component of
Group 5 element magnesium. 230,000 metric tons of niobium ore are produced yearly, with Brazil producing metric 210,000 tons, Canada producing 10000 metric tons, and Australia producing 1000 metric tons. 60000 metric tons of pure niobium are produced each year. 70000 metric tons of tantalum ore are produced yearly. Brazil produces 90% of tantalum ore, with Canada, Australia, China, and Rwanda also producing the element. The demand for tantalum is around 1200 metric tons per year. Dubnium is produced synthetically by bombarding actinides with lighter elements. Vanadium's main application is in alloys, such as vanadium steel. Vanadium alloys are used in springs, tools,