Group 12 element people in the 17th century. German chemist Andreas Marggraf is usually given credit for discovering pure metallic zinc in a 1746 experiment by heating a mixture of calamine and charcoal in a closed vessel without copper to obtain a metal. Experiments on frogs by the Italian doctor Luigi Galvani in 1780 with brass paved the way for the discovery of electrical batteries, galvanization and cathodic protection. In 1880, Galvani's friend, Alessandro Volta, invented the Voltaic pile. The biological importance of zinc was not discovered until 1940 when carbonic anhydrase, an enzyme that scrubs carbon dioxide from blood, was shown to
Pitinga mine By 1990 the mine directly employed 2,000 people, and indirectly perhaps as many as 40,000. Trees were cleared, the river diverted and dams and ponds built before the alluvium deposits were processed. Bucketwheel excavator dredges extracted material rich in cassiterite, which was pumped through pipes to floating processing plants that separated the tin ore. The cassiterite is concentrated on site, then shipped to Mamoré Mineração e Metalurgia in the southern state of São Paulo for casting. Columbite ore is also mined, concentrated and processed on site for use in production of FeNbTa metallic alloy. Up to 1990 a total of