Cholecystitis or scarring of the bile duct. The greatest risk factor for cholecystitis is gallstones. Risk factors for gallstones include female sex, increasing age, pregnancy, oral contraceptives, obesity, diabetes mellitus, ethnicity (Native North American), rapid weight loss. Gallstones blocking the flow of bile account for 90% of cases of cholecystitis (acute calculous cholecystitis). Blockage of bile flow leads to thickening and buildup of bile causing an enlarged, red, and tense gallbladder. The gallbladder is initially sterile but often becomes infected by bacteria, predominantly "E. coli", "Klebsiella", "Streptococcus", and "Clostridium" species. Inflammation can spread to the outer covering of the gallbladder and
Body part as an object aphasics have been put forward since then, including intellectual degradation, and the inability to carry out pretended actions. Denny-Brown takes a more holistic approach and suggested ideational apraxia results from diffuse brain damage. Body part as object is a relatively new concept in scientific literature. Past studies have suggested that BPO pantomimes may allow aphasics to avoid an impaired cognitive function. By not having to reproduce a movement outside of the usual context, they can have a more vivid experience of acting on an object. What is known as BPO pantomiming in children was first discussed in Goodglass and Kaplan’s