Imperial and US customary measurement systems the Troy units of weight—the troy ounce used to this day for weighting precious metals. Edward I (1272–1307) broke the link between a coin's value and its weight when he debased the English coinage by introducing a groat (four pence) which weighed of 89 grains rather than the expected 96 grains. The groat was further devalued in the 1350s when its weight was reduced to 72 grains. During Saxon times land was measured both in terms of its economic value and in terms of its size. The Domesday Book used the hide, an economic unit of measure. In other references
Metals in medicine have been used in treatments since ancient times. The Ebers Papyrus from 1500BC is the first written account of the use of metals for treatment and describes the use of Copper to reduce inflammation and the use of iron to treat anemia. Sodium vanadate has been used since the early 20th century to treat rheumatoid arthritis. Recently metals have been used to treat cancer, by specifically attacking cancer cells and interacting directly with DNA. The positive charge on most metals can interact with the negative charge of the phosphate backbone of DNA. Some drugs developed that include metals interact directly