Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
Niandra LaDes and Usually Just a T-Shirt At one point shortly after release, Frusciante began searching for a string quartet to play the album with him on tour. The idea was eventually discarded when he could not find a band that "understands why Ringo Starr is such a great drummer, can play Stravinsky, and also smokes pot." The concept of a tour was ultimately abandoned as well, due to Frusciante's diminishing health. "Niandra LaDes and Usually Just a T-Shirt" was not widely reviewed, but yielded a generally positive response from critics. Steve Huey of AllMusic, who rated the album four out of five stars, said that "[the