El Greco of Chandax, present day Heraklion) on Crete, El Greco was descended from a prosperous urban family, which had probably been driven out of Chania to Candia after an uprising against the Catholic Venetians between 1526 and 1528. El Greco's father, Geórgios Theotokópoulos (d. 1556), was a merchant and tax collector. Nothing is known about his mother or his first wife, also Greek. El Greco's older brother, Manoússos Theotokópoulos (1531 – 13 December 1604), was a wealthy merchant and spent the last years of his life (1603–1604) in El Greco's Toledo home. El Greco received his initial training as an icon
El Greco claim to rival these masters. As his own commentaries indicate, El Greco viewed Titian, Michelangelo and Raphael as models to emulate. In his 17th century "Chronicles", Giulio Mancini included El Greco among the painters who had initiated, in various ways, a re-evaluation of Michelangelo's teachings. Because of his unconventional artistic beliefs (such as his dismissal of Michelangelo's technique) and personality, El Greco soon acquired enemies in Rome. Architect and writer Pirro Ligorio called him a "foolish foreigner", and newly discovered archival material reveals a skirmish with Farnese, who obliged the young artist to leave his palace. On 6 July 1572,