Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
Niandra LaDes and Usually Just a T-Shirt Niandra LaDes and Usually Just a T-Shirt Niandra LaDes and Usually Just a T-Shirt is the debut solo album by John Frusciante, released on November 22, 1994, on American Recordings. Frusciante released the album after encouragement from several friends, who told him that there was "no good music around anymore." "Niandra LaDes and Usually Just a T-Shirt" combines avant-garde and stream-of-consciousness styles, with guitar, piano and various effects on a four-track recorder. The album's first half, "Niandra LaDes", was recorded before Frusciante left the Red Hot Chili Peppers in 1992, during the recording of "Blood Sugar Sex Magik". The second