Carbolic soap Carbolic soap Carbolic soap is a mildly antiseptic soap containing carbolic acid and/or cresylic acid, both of which are phenols derived from either coal tar or petroleum sources. In 1834, German chemist Friedlieb Ferdinand Runge discovered a phenol, now known as carbolic acid, which he derived in an impure form from coal tar. In August 1865, Dr. Joseph Lister, 1st Baron Lister applied a piece of lint dipped in carbolic acid solution onto the wound of an eleven-year-old boy at Glasgow Royal Infirmary, who had sustained a compound fracture after a cart wheel had passed over his leg. After four
Aminoshikimic acid Aminoshikimic acid Aminoshikimic acid is a synthetic crystalline carboxylic acid. It is characterized by multiple stereogenic centers and functional groups arrayed around a six-membered carbocyclic ring. Aminoshikimic acid is also an alternative to shikimic acid as a starting material for the synthesis of neuraminidase inhibitors such as the antiinfluenza agent oseltamivir (Tamiflu). Aminoshikimic acid is an unnatural carbohydrate, although aminoshikimic acid is the namesake of the aminoshikimate pathway, which generates the 3-amino-5-hydroxybenzoic acid (AHBA) starter unit required for the biosynthesis of the ansamycins and mitomycins. The first microbe-catalyzed syntheses of aminoshikimic acid were described by Guo and Frost in 2004.