Group 12 element people in the 17th century. German chemist Andreas Marggraf is usually given credit for discovering pure metallic zinc in a 1746 experiment by heating a mixture of calamine and charcoal in a closed vessel without copper to obtain a metal. Experiments on frogs by the Italian doctor Luigi Galvani in 1780 with brass paved the way for the discovery of electrical batteries, galvanization and cathodic protection. In 1880, Galvani's friend, Alessandro Volta, invented the Voltaic pile. The biological importance of zinc was not discovered until 1940 when carbonic anhydrase, an enzyme that scrubs carbon dioxide from blood, was shown to
Pnictogen be produced by fractional distillation of air. The principal method for producing phosphorus is to reduce phosphates with carbon in an electric arc furnace. Most arsenic is prepared by heating the mineral arsenopyrite in the presence of air. This forms AsO, from which arsenic can be extracted via carbon reduction. However, it is also possible to make metallic arsenic by heating arsenopyrite at 650 to 700 °C without oxygen. With sulfide ores, the method by which antimony is produced depends on the amount of antimony in the raw ore. If the ore contains 25% to 45% antimony by weight, then