Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
Niandra LaDes and Usually Just a T-Shirt album "Smile From the Streets You Hold", primarily for drug money. "Niandra LaDes and Usually Just a T-Shirt" was estimated to have sold only 45,000 copies when Frusciante ordered it out of print in 1998—when Frusciante rehabilitated and rejoined the Chili Peppers. "Smile From the Streets You Hold" was withdrawn from the market a year later. In 1999 "Niandra LaDes and Usually Just a T-Shirt" was re-released on American Recordings. In the early 2000s, Frusciante said he planned to re-release "Smile From the Streets You Hold" sometime in the future, but did not give any indication as to when. It