English and British royal mistress period. Afterwards, he rejected any possible marriage he might have made with Mrs. Fitzherbert. His other notable mistresses included Mary Robinson, Frances Twysden, Grace Elliott, Isabella Seymour-Conway, Marchioness of Hertford and Elizabeth Conyngham, Marchioness Conyngham. George IV and his legitimate wife Caroline of Brunswick were never fond of their arranged marriage and lived separately from 1796 to her death on 7 August 1821. Their only daughter Princess Charlotte of Wales was born very early in the marriage. That both George and Caroline took other lovers was not therefore unexpected. George survived his only legitimate daughter. He was succeeded by his
Diseases and epidemics of the 19th century Diseases and epidemics of the 19th century Diseases and epidemics of the 19th century reached epidemic proportions in the case of one emerging infectious disease: cholera. Other important diseases at that time in Europe and other regions included smallpox, typhus and yellow fewer. Epidemics of the 19th century were faced without the medical advances that made 20th-century epidemics much more rare and less lethal. Micro-organisms (viruses and bacteria) had been discovered in the 18th century, but it was not until the late 19th century that the experiments of Lazzaro Spallanzani and Louis Pasteur disproved spontaneous generation conclusively, allowing germ theory