Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
Niandra LaDes and Usually Just a T-Shirt under different names on the album "Smile from the Streets You Hold" in 1997. "Niandra LaDes and Usually Just a T-Shirt" incorporated Frusciante's avant-garde style of song composition, with his stream-of-consciousness methodology. He recorded, mixed, produced and mastered the entire record by himself, and released it on Rick Rubin's label, American Recordings. Warner Bros., the Chili Peppers' label, originally held the rights to the album because of the leaving-artist clause in Frusciante's Chili Peppers contract. Because he was living as a recluse, however, the label gladly handed the rights over to Rubin, who released the album under his label. "Niandra