Group 12 element people in the 17th century. German chemist Andreas Marggraf is usually given credit for discovering pure metallic zinc in a 1746 experiment by heating a mixture of calamine and charcoal in a closed vessel without copper to obtain a metal. Experiments on frogs by the Italian doctor Luigi Galvani in 1780 with brass paved the way for the discovery of electrical batteries, galvanization and cathodic protection. In 1880, Galvani's friend, Alessandro Volta, invented the Voltaic pile. The biological importance of zinc was not discovered until 1940 when carbonic anhydrase, an enzyme that scrubs carbon dioxide from blood, was shown to
Schlangenberg Nature Reserve the surface where erosion removed large amounts. About 200 million years ago aqueous metal solutions filled the cavernous rocks. Primary ores were created mostly consisting of Sphalerite, Marcasite and Galena. The process continued and the ore close to the surface decomposed due to the influence of carbon dioxide and water. In this process as a secondary ore calamine ZnCO which is known as calamine developed. Presumably the Celts had been the first digging for the calamine in the region. Ancient Celtic and Roman coins dated between 100 BC and 92/93 AD as well as remains of a Roman settlement proved