Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
What Just Happened What Just Happened What Just Happened is a 2008 American satirical comedy-drama directed by Barry Levinson and starring Robert De Niro. The supporting cast includes Catherine Keener, Robin Wright Penn, Stanley Tucci, and Sean Penn. "What Just Happened" is an independent film, produced by 2929 Productions, Art Linson Productions and Tribeca Productions, and was released on October 17, 2008. The film is based on the book "What Just Happened? Bitter Hollywood Tales from the Front Line" by Art Linson, about his experiences as a producer in Hollywood. This film was shown at the Cannes Film Festival on May 25, 2008.