Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
What the (Bleep) Just Happened? What the (Bleep) Just Happened? What the (Bleep) Just Happened?: The Happy Warrior's Guide to the Great American Comeback is a withdrawn 2012 book by Fox News contributor Monica Crowley. It was published by Broadside Books, a HarperCollins imprint. "What the (Bleep) Just Happened?" was a New York Times bestseller. In 2013, the book was re-released with an afterword and the title "What the (Bleep) Just Happened... Again?: The Happy Warrior's Guide to the Great American Comeback". According to Crowley, the book's name came from a conversation she had with her friend about the Obama administration: Kirkus Reviews panned the