Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
Giving What We Can evaluations across broad areas of work such as health, education, and emergency aid before comparing specific organizations. In practice, it recommends a selected few charities in the area of global health. Its work is therefore similar to that of GiveWell. Giving What We Can Giving What We Can (GWWC) is an effective altruism associated organization whose members pledge to give 10% of their income to effective charities. It was founded at Oxford University in 2009 by the ethics researcher Toby Ord. Giving What We Can was founded as a giving society in 2009 by Toby Ord, an ethics researcher at