Group 12 element people in the 17th century. German chemist Andreas Marggraf is usually given credit for discovering pure metallic zinc in a 1746 experiment by heating a mixture of calamine and charcoal in a closed vessel without copper to obtain a metal. Experiments on frogs by the Italian doctor Luigi Galvani in 1780 with brass paved the way for the discovery of electrical batteries, galvanization and cathodic protection. In 1880, Galvani's friend, Alessandro Volta, invented the Voltaic pile. The biological importance of zinc was not discovered until 1940 when carbonic anhydrase, an enzyme that scrubs carbon dioxide from blood, was shown to
Christopher Schutz to mine and process the ore, being joined in some of their licences with Thomas Smythe, William Williams and Humfrey Cole. Only a few months later, in early 1566, William Humfrey and Schutz found calamine in the Mendip Hills, and Daniel Hoechstetter designed a refining process by which it could be used in Schutz' furnace at Tintern. As a reward for his work at Tintern, Schutz was granted denization on 9 April 1568, but the extraction of calamine ore at Worle Hill proved prohibitively expensive for the production of brass, and on 28 May the Company of Mineral and Battery