Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
Niandra LaDes and Usually Just a T-Shirt slightly more tuneful than the more ambient, experimental second section[...] Mostly what you get are Frusciante's acoustic-guitar scratchings and stream-of-conscious ramblings." The first "Rolling Stone" review of the record, however, was positive: "All in all, [the album is] a mess—but definitely a fascinating, often lovely mess. As one might expect of an album titled "Niandra Lades and Usually Just a T-shirt" this is twisted, cool stuff." The "Boston Herald" said that while the album was "a stark display of Frusciante's acoustic guitar virtuosity" and "eerily beautiful", the singing was "terrible; his high notes will drive the neighborhood dogs into a