Great Bustard Memorandum of Understanding Herzegovina, Bulgaria, Croatia, Czech Republic, European Union, Germany, Greece, Hungary, Moldova, Poland, Romania, Slovakia, Slovenia, The Republic of Macedonia and Ukraine). As of August 2012, 13 range states have signed the MoU as well as a number of cooperating organizations. To implement the decision of the Fourth Conference of the Parties of CMS to list the great bustard ("Otis tarda") on Appendix II of the Convention as a consequence of its unfavourable conservation status and the conviction that the species could benefit from an international agreement for its conservation and management and the middle-European population on Appendix I of the
Porphyria cutanea tarda the body. Certain mutations in the "HFE" gene cause hemochromatosis (an iron overload disorder). People who have these mutations are also at an increased risk of developing porphyria cutanea tarda. In the 20% of cases where porphyria cutanea tarda is inherited, it is inherited in an autosomal dominant pattern, which means one copy of the altered gene is sufficient to decrease enzyme activity and cause the signs and symptoms of the disorder. While inherited deficiencies in uroporphyrinogen decarboxylase often lead to the development of PCT, there are a number of risk factors that can both cause and exacerbate the symptoms