Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
What the (Bleep) Just Happened? Journal" containing "striking similarities" (according to the "Journal") with a piece written eleven years earlier by Paul Johnson. The next day, HarperCollins announced that ""What the (Bleep) Just Happened?", which has reached the end of its natural sales cycle, will no longer be offered for purchase until such time as the author has the opportunity to source and revise the material." What the (Bleep) Just Happened? What the (Bleep) Just Happened?: The Happy Warrior's Guide to the Great American Comeback is a withdrawn 2012 book by Fox News contributor Monica Crowley. It was published by Broadside Books, a HarperCollins imprint.