Cholecystitis or scarring of the bile duct. The greatest risk factor for cholecystitis is gallstones. Risk factors for gallstones include female sex, increasing age, pregnancy, oral contraceptives, obesity, diabetes mellitus, ethnicity (Native North American), rapid weight loss. Gallstones blocking the flow of bile account for 90% of cases of cholecystitis (acute calculous cholecystitis). Blockage of bile flow leads to thickening and buildup of bile causing an enlarged, red, and tense gallbladder. The gallbladder is initially sterile but often becomes infected by bacteria, predominantly "E. coli", "Klebsiella", "Streptococcus", and "Clostridium" species. Inflammation can spread to the outer covering of the gallbladder and
Theology of the Body nature of human beings in relation to God. The "Theology of the Body" presents an interpretation of the fundamental significance of the body, and in particular of sexual differentiation and complementarity, one which aims to challenge common contemporary philosophical views. Nevertheless, the pope's personalistic phenomenology is "echoing what he learned from St. John of the Cross" and is "in harmony with St. Thomas Aquinas". Francis Bacon was an early empiricist who focused on problems of knowledge. In his Great Instauration, he argued that the current state of knowledge is immature and not advancing. His purpose was for the human mind