Mammary gland gestation, serum progesterone remains at a stably high concentration so signaling through its receptor is continuously activated. As one of the transcribed genes, Wnts secreted from mammary epithelial cells act paracrinely to induce more neighboring cells' branching. When the lactiferous duct tree is almost ready, "leaves" alveoli are differentiated from luminal epithelial cells and added at the end of each branch. In late pregnancy and for the first few days after giving birth, colostrum is secreted. Milk secretion (lactation) begins a few days later due to reduction in circulating progesterone and the presence of another important hormone prolactin, which mediates
Milk caps (game) used is a slammer: a heavier game piece often made of metal, rubber, or more commonly plastic, which come in various thicknesses and weights. They are typically similar in diameter to milk caps. Metal slammers are not allowed in some games because they are usually heavier than other materials, giving the player with the first turn an unfair advantage, and have a tendency to damage the milk caps. Rules vary among players, but the game variants generally have common gameplay features. Each player has his/her own collection of milk caps and one or more slammers. Before the game, players decide