Cholecystitis or scarring of the bile duct. The greatest risk factor for cholecystitis is gallstones. Risk factors for gallstones include female sex, increasing age, pregnancy, oral contraceptives, obesity, diabetes mellitus, ethnicity (Native North American), rapid weight loss. Gallstones blocking the flow of bile account for 90% of cases of cholecystitis (acute calculous cholecystitis). Blockage of bile flow leads to thickening and buildup of bile causing an enlarged, red, and tense gallbladder. The gallbladder is initially sterile but often becomes infected by bacteria, predominantly "E. coli", "Klebsiella", "Streptococcus", and "Clostridium" species. Inflammation can spread to the outer covering of the gallbladder and
The Body in the Library earlier, Anne Meredith knows Ariadne Oliver as the writer of a book called "The Body in the Library". In the first episode of the second series ("And the Moonbeams Kiss the Sea") of the television series "Lewis," the body of a handyman is found in the Bodleian Library. DS James Hathaway comments to DI Robbie Lewis, "You realise what we've got, don't you, sir. ... The body in the library." The 1984 television film "The Body in the Library" was part of the BBC series of "Miss Marple", with Joan Hickson making the first of her acclaimed appearances in the