Cholecystitis or scarring of the bile duct. The greatest risk factor for cholecystitis is gallstones. Risk factors for gallstones include female sex, increasing age, pregnancy, oral contraceptives, obesity, diabetes mellitus, ethnicity (Native North American), rapid weight loss. Gallstones blocking the flow of bile account for 90% of cases of cholecystitis (acute calculous cholecystitis). Blockage of bile flow leads to thickening and buildup of bile causing an enlarged, red, and tense gallbladder. The gallbladder is initially sterile but often becomes infected by bacteria, predominantly "E. coli", "Klebsiella", "Streptococcus", and "Clostridium" species. Inflammation can spread to the outer covering of the gallbladder and
What Is History? What Is History? What Is History? is a study that was written by the English historian E. H. Carr. It was first published by Cambridge University Press in 1961. It discusses history, facts, the bias of historians, science, morality, individuals and society, and moral judgements in history. The book was originally part of a series of G. M. Trevelyan lectures given by Carr in 1961 at the University of Cambridge. The lectures were intended as a broad introduction into the subject of the theory of history. Some of Carr's ideas are contentious, particularly his alleged relativism and his rejection of