Adjective may be more rigid in some languages than others; in some, like Spanish, it may only be a default ("unmarked") word order, with other orders being permissible. Other languages, such as Tagalog, follow their adjectival orders as rigidly as English. The normal adjectival order of English may be overridden in certain circumstances, especially when one adjective is being fronted. In addition, the usual order of adjectives in English would result in the phrase "the bad big wolf" (opinion before size), but instead the usual phrase is "the big bad wolf", perhaps because the ablaut reduplication rule that high vowels precede
Alternatives to animal testing Data. Alternatives to animal testing Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved. Two major alternatives to "in vivo" animal testing are "in vitro" cell culture techniques and "in silico" computer simulation. However, some claim they are not true alternatives because simulations use data from prior animal experiments and cell cultures often require animal derived products, such as serum or