Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
Manganese recovery of the manganese. For further purification, the manganese can then be sent to an electrowinning facility. In 1972 the CIA's Project Azorian, through billionaire Howard Hughes, commissioned the ship "Hughes Glomar Explorer" with the cover story of harvesting manganese nodules from the sea floor. That triggered a rush of activity to collect manganese nodules, which was not actually practical. The real mission of "Hughes Glomar Explorer" was to raise a sunken Soviet submarine, the K-129, with the goal of retrieving Soviet code books. Manganese has no satisfactory substitute in its major applications in metallurgy. In minor applications, (e.g., manganese