Ruta graveolens the isolation of the furanocoumarin chalepensin. The essential oil of "R. graveolens" contains two main constituents, undecan-2-one (46.8%) and nonan-2-one (18.8%). The bitter taste of its leaves led to rue being associated with the (etymologically unrelated) verb "rue" "to regret". Rue is well known for its symbolic meaning of regret and it has sometimes been called "herb-of-grace" in literary works. It is one of the flowers distributed by the mad Ophelia in William Shakespeare's "Hamlet" (IV.5): It was planted by the gardener in "Richard II" to mark the spot where the Queen wept upon hearing news of Richard's capture (III.4.104–105):
Gertrude (Hamlet) Watts portrayed Gertrude in Claire McCarthy's 2018 "Ophelia". "Gertrude and Claudius", a John Updike novel, serves as a prequel to the events of the play. It follows Gertrude from her wedding to King Hamlet, through an affair with Claudius, and its murderous results, until the very beginning of the play. Gertrude also appears as a character in Howard Barker's "Gertrude—The Cry", which uses some of the characters from "Hamlet". "Hamlet" has played "a relatively small role" in the appropriation of Shakespeare's plays by women writers. Margaret Atwood's ""Gertrude Talks Back"", in her 1992 collection of short stories "Good Bones", sees