Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
SS Manganese was sold to the Sinai Manganese Co, Egypt and was renamed "Manganese". The ship was deleted from Lloyd's Register in 1993. SS Manganese Manganese was a coaster that was built in 1925 by Norderwerft AG, Hamburg, Germany as Wiedau for German owners. She was seized by the Allies in May 1945, passed to the Ministry of War Transport (MoWT) and was renamed Empire Contract. Later that year, she was transferred to Greece and renamed "Herakleion". She was sold into merchant service in 1948 and renamed Laconia. In 1965, she was sold to Egypt and renamed "Manganese". The ship was deleted