Nerve plexus nerves form the Sacral plexus. It is located on the posterior wall of pelvic cavity (pelvis minor). Nervi of the plexus innervate the perineal region, buttocks and the lower limb. The largest nerve of the human body, the sciatic nerve is the main branch, that give rami to the motor innervation of the muscles of the foot, the leg and the thigh. Common peroneal nerve and its branches innervate some part of the skin of the foot, the peroneal muscles of the leg and the dorsal muscles of the foot. Coccygeal plexus originate from S4, S5, Co1 spinal nerves. It
Nerve allograft to bridge the gap is nerve allotransplantation. Nerve allografts are prepared from donated human nerve tissue. An allograft contains many of the beneficial characteristics of nerve autograft, such as three-dimensional microstructural scaffolding and protein components inherent to nerve tissue. One of the adverse effects of nerve allotransplantation is the immunogenic response. Tissue from another human being is used to restore the defect, which can induce an immunogenic response. An immune response against an allograft or xenograft is called Transplant rejection. To prevent this rejection, new immunosuppressive techniques are performed on the graft, before it is transplanted into the receiver. The