North America metropolitan area by population in North America: Greater Mexico City. Canada also breaks into the top ten largest metropolitan areas with the Toronto metropolitan area having six million people. The proximity of cities to each other on the Canada–United States border and Mexico–United States border has led to the rise of international metropolitan areas. These urban agglomerations are observed at their largest and most productive in Detroit–Windsor and San Diego–Tijuana and experience large commercial, economic, and cultural activity. The metropolitan areas are responsible for millions of dollars of trade dependent on international freight. In Detroit-Windsor the Border Transportation Partnership study
HIV/AIDS in North America for Disease and Control and Prevention (CDC), African-American accounted for 44% of all new HIV infections in the United States between 2010 and 2016, although African-Americans make up roughly 12% of the American population. The extent of the HIV/AIDS crisis within the African-American community is an indication that the solution will also need to be multi-faceted ranging from increasing access to health care to reducing the stigma that HIV and homosexuality has within the African-American community. HIV/AIDS in North America As of 2016, it is estimated that there are 1.5 million adults and children living with HIV/AIDS in North America,