Ruta graveolens the isolation of the furanocoumarin chalepensin. The essential oil of "R. graveolens" contains two main constituents, undecan-2-one (46.8%) and nonan-2-one (18.8%). The bitter taste of its leaves led to rue being associated with the (etymologically unrelated) verb "rue" "to regret". Rue is well known for its symbolic meaning of regret and it has sometimes been called "herb-of-grace" in literary works. It is one of the flowers distributed by the mad Ophelia in William Shakespeare's "Hamlet" (IV.5): It was planted by the gardener in "Richard II" to mark the spot where the Queen wept upon hearing news of Richard's capture (III.4.104–105):
Ophelia brothel. Polonius instructs Ophelia to stand in the lobby of the castle while he and Claudius hide. Hamlet approaches Ophelia and talks to her, saying "Get thee to a nunnery." Hamlet asks Ophelia where her father is and she lies to him, saying her father must be at home. Hamlet realises he is being spied upon. He exits after declaring, "I say we will have no more marriages." Ophelia is left bewildered and heartbroken, sure that Hamlet is insane. She knows that ultimately it is she that broke him because she lied. She was the woman he had loved and