Magnesium in biology be used as adjuvant therapy in patients on optimal treatment for severe congestive heart failure, increasing survival rate and improving clinical symptoms and patient's quality of life. Magnesium can affect muscle relaxation through direct action on cell membranes. Mg ions close certain types of calcium channels, which conduct positively charged calcium ions into neurons. With an excess of magnesium, more channels will be blocked and nerve cells activity will decrease. Intravenous magnesium sulphate is used in treating pre-eclampsia. For other than pregnancy-related hypertension, a meta-analysis of 22 clinical trials with dose ranges of 120 to 973 mg/day and a mean
Magnesium oxide negra", a black mineral containing what is now known as manganese. While "magnesium oxide" normally refers to MgO, magnesium peroxide MgO is also known as a compound. According to evolutionary crystal structure prediction, MgO is thermodynamically stable at pressures above 116 GPa (gigapascals), and a semiconducting suboxide MgO is thermodynamically stable above 500 GPa. Because of its stability, MgO is used as a model system for investigating vibrational properties of crystals. Magnesium oxide is produced by the calcination of magnesium carbonate or magnesium hydroxide. The latter is obtained by the treatment of magnesium chloride solutions, typically seawater, with lime. Calcining