Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
Manganese, Minnesota Manganese, Minnesota Manganese was a small village in Wolford Township, Crow Wing County, Minnesota, United States. Manganese lies roughly north of Trommald, Minnesota. Just off County Road 30, it is perhaps best identified by its location between Coles Lake and Flynn Lake. First appearing in the 1920 census, the village was abandoned by 1960. Named after the mining of its namesake, the village first appeared as "Manganese Village" in the 1920 Census with a population of 183. A post office called Manganese was in operation from 1912 until 1924. Over time, like most other minerals in the Cuyuna Range, all