Manganese is also used in portland cement mixtures. Manganese is an important element for human health, essential for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and symptoms similar to Parkinson's disease. The classes of enzymes that have manganese cofactors is large and includes oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, lectins, and integrins. The reverse transcriptases of many retroviruses (though not lentiviruses such as HIV) contain manganese. The best-known manganese-containing polypeptides may be arginase, the diphtheria toxin, and Mn-containing superoxide dismutase (Mn-SOD).
Manganese nodule Manganese nodule Polymetallic nodules, also called manganese nodules, are rock concretions on the sea bottom formed of concentric layers of iron and manganese hydroxides around a core. The core may be microscopically small and is sometimes completely transformed into manganese minerals by crystallization. When visible to the naked eye, it can be a small test (shell) of a microfossil (radiolarian or foraminifer), a phosphatized shark tooth, basalt debris or even fragments of earlier nodules. As nodules can be found in vast quantities, and contain valuable metals, deposits were identified as having economic interest in the 1960s by John Mero. Nodules