Tobacco methods. Some examples are: Smoking in public was, for a long time, reserved for men, and when done by women was sometimes associated with promiscuity; in Japan, during the Edo period, prostitutes and their clients often approached one another under the guise of offering a smoke. The same was true in 19th-century Europe. Following the American Civil War, the use of tobacco, primarily in cigars, became associated with masculinity and power. Today, tobacco use is often stigmatized; this has spawned quitting associations and antismoking campaigns. Bhutan is the only country in the world where tobacco sales are illegal. Due to
Animals and tobacco smoke various types of animals have also been exposed to tobacco smoke inhalation in attempts to yield further experimental proof and control for various experimental factors, including types of tobacco and levels of exposure, which would be considered unethical in human studies. The IARC monographs, referencing studies which used various methods of smoke inhalation, concluded that a significantly greater number of pulmonary tumors occurred among mice exposed to smoke than those in the control groups. Since the 1960s, the animal most used in testing the carcinogenicity of tobacco smoke has been the Syrian Golden Hamster due to its resistance to pulmonary