Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
Manganese exporter manganese efflux pump. Manganese sensitivity and intracellular manganese levels significantly increased in bacteria when the "mntP" (formerly "yebN") gene, which encodes the MntP efflux pump, was deleted. While manganese is a highly important trace nutrient for organisms from bacteria to humans, acting as an important element in the defense against oxidative stress and as an enzyme cofactor, it becomes toxic when present in excess. Manganese exporter The Manganese (Mn2+) Exporter (MntP) Family (TC# 2.A.107) is a member of the Lysine Exporter (LysE) Superfamily. The MntP family is a small family whose members have been found in bacteria and archaea. MntP