Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
Lithium ion manganese oxide battery made of alternating layers of lithium ions and lithium and manganese ions in a 1:2 ratio, similar to the layered structure of . Although is electrochemically inactive, it can be charged to a high potential (4.5 V v.s Li) in order to undergo lithiation/de-lithiation. However, extracting lithium from at such a high potential results in loss of oxygen from the electrode surface which leads to poor capacity and cycling stability. One of the main research efforts in the field of lithium-manganese oxide electrodes for lithium-ion batteries involves developing composite electrodes using structurally integrated layered and spinel , with a chemical