Ruta graveolens the isolation of the furanocoumarin chalepensin. The essential oil of "R. graveolens" contains two main constituents, undecan-2-one (46.8%) and nonan-2-one (18.8%). The bitter taste of its leaves led to rue being associated with the (etymologically unrelated) verb "rue" "to regret". Rue is well known for its symbolic meaning of regret and it has sometimes been called "herb-of-grace" in literary works. It is one of the flowers distributed by the mad Ophelia in William Shakespeare's "Hamlet" (IV.5): It was planted by the gardener in "Richard II" to mark the spot where the Queen wept upon hearing news of Richard's capture (III.4.104–105):
Ophelia Project that the ill would get better were higher. In 1905 a competition was announced. The prize of 600 lire was given to Giuseppe Quaroni and Marcello Piacentini for the Ophelia project. Quaroni, an engineer, and Piacentini, an architect, were both from Rome and they named their project after the Hamlet character, Ophelia, who goes mad and drowns herself in Shakespeare’s tragedy (“O heat, dry up my brains! Tears seven times salt burn out the sense and virtue of mine eye. By heaven, thy madness shall be paid with weight…”(act IV, scene V). The estimated outlay for the project was of