Magnesium in biology be used as adjuvant therapy in patients on optimal treatment for severe congestive heart failure, increasing survival rate and improving clinical symptoms and patient's quality of life. Magnesium can affect muscle relaxation through direct action on cell membranes. Mg ions close certain types of calcium channels, which conduct positively charged calcium ions into neurons. With an excess of magnesium, more channels will be blocked and nerve cells activity will decrease. Intravenous magnesium sulphate is used in treating pre-eclampsia. For other than pregnancy-related hypertension, a meta-analysis of 22 clinical trials with dose ranges of 120 to 973 mg/day and a mean
Magnesium oxychloride It can be prepared by calcination of magnesium hydroxycarbonate ·4 at about 600 °C. (Higher temperatures increase particle size leading to lower reaction rate.) It is believed that, during the reaction, the magnesium oxide is continuously hydrated and dissolved, helped by the slightly acidic character of the magnesium chloride solution. The acidity is attributed to hydrolysis of the magnesium hexahydrate cations: The protons (which are actually hydrated, e.g. as ) make the solution acidic; the pH varies from 6.5 to 4.7 as the concentration of increases from 30% to 70% (weight basis). The protons then react with and dissolve the