Doctor Who show, as the story begins anew with each companion and she undergoes more change than the Doctor. The primary companions of the Ninth and Tenth Doctors were Rose Tyler (Billie Piper), Martha Jones (Freema Agyeman), and Donna Noble (Catherine Tate) with Mickey Smith (Noel Clarke) and Jack Harkness (John Barrowman) recurring as secondary companion figures. The Eleventh Doctor became the first to travel with a married couple, Amy Pond (Karen Gillan) and Rory Williams (Arthur Darvill), whilst out-of-sync meetings with River Song (Alex Kingston) and Clara Oswald (Jenna Coleman) provided ongoing story arcs. The tenth series introduced Pearl Mackie as
Doctor Who Doctor's nature, somewhere between the twelfth and final incarnation. On rare occasions, other actors have stood in for the lead. In "The Five Doctors", Richard Hurndall played the First Doctor due to William Hartnell's death in 1975; 34 years later David Bradley similarly replaced Hartnell in "Twice Upon a Time". In "Time and the Rani", Sylvester McCoy briefly played the Sixth Doctor during the regeneration sequence, carrying on as the Seventh. For more information, see the list of actors who have played the Doctor. In other media, the Doctor has been played by various other actors, including Peter Cushing in