Stomach or compound racemose resembling the duodenal Brunner's glands The "fundic glands", are found in the fundus and body of the stomach. They are simple almost straight tubes, two or more of which open into a single duct. They secrete hydrochloric acid (HCl) and intrinsic factor. The "pyloric glands" are located in the antrum of the pylorus. They secrete gastrin produced by their G cells. About 20,000 protein coding genes are expressed in human cells and nearly 70% of these genes are expressed in the normal stomach. Just over 150 of these genes are more specifically expressed in the stomach compared
Gastric acid excess vomiting, patients develop hypochloremic metabolic alkalosis (decreased blood acidity by H and chlorine depletion). The proton pump enzyme is the target of proton pump inhibitors, used to increase gastric pH (and hence decrease stomach acidity) in diseases that feature excess acid. H antagonists indirectly decrease gastric acid production. Antacids neutralize existing acid. The role of gastric acid in digestion was established in the 1820s and 1830s by William Beaumont on Alexis St. Martin, who, as a result of an accident, had a fistula (hole) in his stomach, which allowed Beaumont to observe the process of digestion and to extract