Magnesium in biology be used as adjuvant therapy in patients on optimal treatment for severe congestive heart failure, increasing survival rate and improving clinical symptoms and patient's quality of life. Magnesium can affect muscle relaxation through direct action on cell membranes. Mg ions close certain types of calcium channels, which conduct positively charged calcium ions into neurons. With an excess of magnesium, more channels will be blocked and nerve cells activity will decrease. Intravenous magnesium sulphate is used in treating pre-eclampsia. For other than pregnancy-related hypertension, a meta-analysis of 22 clinical trials with dose ranges of 120 to 973 mg/day and a mean
Should've Known Better (Richard Marx song) for two weeks and remained on the chart for 13 weeks. Elsewhere, the single reached number 50 in the United Kingdom. Should've Known Better (Richard Marx song) "Should've Known Better" is a hit song written, composed, and performed by American rock singer Richard Marx, who released in September 1987 as the second single from his self-titled debut album. The song peaked at number three on the US "Billboard" Hot 100 as well as #7 on the "Billboard" Mainstream Rock Tracks chart in 1987 and #4 on the Radio & Records CHR/Pop Airplay chart. Marx became the first solo artist in