Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
Manganese heptoxide Manganese heptoxide Manganese(VII) oxide (manganese heptoxide) is an inorganic compound with the formula MnO. This volatile liquid is highly reactive and more often discussed than intentionally prepared. It is a dangerous oxidizer and was first described in 1860. It is the acid anhydride of permanganic acid. The crystalline form of this chemical compound is dark green. The liquid is green by reflected light and red by transmitted light. It is soluble in carbon tetrachloride, and decomposes when in contact with water. It melts at only 5.9 °C, and sublimes at −10 °C. These properties indicate a nonpolar molecular species, which