Ruta graveolens the isolation of the furanocoumarin chalepensin. The essential oil of "R. graveolens" contains two main constituents, undecan-2-one (46.8%) and nonan-2-one (18.8%). The bitter taste of its leaves led to rue being associated with the (etymologically unrelated) verb "rue" "to regret". Rue is well known for its symbolic meaning of regret and it has sometimes been called "herb-of-grace" in literary works. It is one of the flowers distributed by the mad Ophelia in William Shakespeare's "Hamlet" (IV.5): It was planted by the gardener in "Richard II" to mark the spot where the Queen wept upon hearing news of Richard's capture (III.4.104–105):
Ophelia Ophelia Ophelia () is a character in William Shakespeare's drama "Hamlet". She is a young noblewoman of Denmark, the daughter of Polonius, sister of Laertes, and potential wife of Prince Hamlet. As with virtually all "Hamlet" characters, Ophelia's name is not Danish. It first appeared in Jacopo Sannazaro's 1504 poem "Arcadia" (as "Ofelia"), probably derived from Ancient Greek ὠφέλεια ("ōphéleia", "help"). In Ophelia's first speaking appearance in the play, she is seen with her brother, Laertes, who is leaving for France. Laertes warns her that Hamlet, the heir to the throne of Denmark, does not have the freedom to marry