Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
Manganese Mines Mines Wildlife Management Area, a conservation area. The main industry is now farming. The name of this community derives from the discovery and mining of manganese here, beginning in the 1880s and ending in the 1890s. Also, Lafarge Canada operated a limestone quarry at Manganese Mines which closed in 1996. The limestone was used to produce cement. Manganese Mines Manganese Mines is an unincorporated community in Colchester County, Nova Scotia, Canada. This community is located about six miles north-east of Truro, between the South Branch North River and the Salmon River. The land was previously part of Onslow Township. It