Manganese produce a parkinsonism-like illness characterized by movement abnormalities. This condition is not responsive to typical therapies used in the treatment of PD, suggesting an alternative pathway than the typical dopaminergic loss within the substantia nigra. Manganese may accumulate in the basal ganglia, leading to the abnormal movements. A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this Parkinsonism-like disease. The Lewy bodies typical to PD are not seen in Mn-induced parkinsonism. Animal experiments have given the opportunity to examine the consequences of manganese overexposure under controlled conditions.
CB military symbol by the United States – signifying crude mustard. In the Second World War the purity of mustard gas was improved through distillation, and this purified chemical warfare agent was designated HD. When it was mixed with a thickener (Agent VV), it was given the symbol HV. Today mustard gas is indicated by the single capital letter H, but HD is still in common use. Military symbols can also reflect the name of where a chemical agent is manufactured. For example, chloropicrin has the symbol PS, which was derived from the British town in which it was manufactured during the First