Ruta graveolens the isolation of the furanocoumarin chalepensin. The essential oil of "R. graveolens" contains two main constituents, undecan-2-one (46.8%) and nonan-2-one (18.8%). The bitter taste of its leaves led to rue being associated with the (etymologically unrelated) verb "rue" "to regret". Rue is well known for its symbolic meaning of regret and it has sometimes been called "herb-of-grace" in literary works. It is one of the flowers distributed by the mad Ophelia in William Shakespeare's "Hamlet" (IV.5): It was planted by the gardener in "Richard II" to mark the spot where the Queen wept upon hearing news of Richard's capture (III.4.104–105):
Ophelia as one of the most poetic death announcements in literature. Later, a sexton at the graveyard insists Ophelia must have killed herself. Laertes is outraged by what the cleric says, and replies that Ophelia will be an angel in heaven when the cleric "lie[s] howling" in hell. At Ophelia's funeral, Queen Gertrude sprinkles flowers on Ophelia's grave ("Sweets to the sweet"), and says she wished Ophelia could have been Hamlet's wife (contradicting Laertes' warnings to Ophelia in the first act). Laertes then jumps into Ophelia's grave excavation, asking for the burial to wait until he has held her in his