Tobacco methods. Some examples are: Smoking in public was, for a long time, reserved for men, and when done by women was sometimes associated with promiscuity; in Japan, during the Edo period, prostitutes and their clients often approached one another under the guise of offering a smoke. The same was true in 19th-century Europe. Following the American Civil War, the use of tobacco, primarily in cigars, became associated with masculinity and power. Today, tobacco use is often stigmatized; this has spawned quitting associations and antismoking campaigns. Bhutan is the only country in the world where tobacco sales are illegal. Due to
Tobacco smoke by the unprotonated form is a pH of 8. At pH 8, the two fractions are present in equal parts. At any lower pH, the fraction of protonated nicotine is greater. More unprotonated nicotine in tobacco smoke increases smoke "strength", "impact", or "kick". However, the irritation and harshness of smoke at higher pH makes it harder for smokers to inhale it. Cigarette design ensures that the smoke has enough unprotonated nicotine to rapidly transfer nicotine into the brain but not so much of it as to be too harsh for the smoker. Variability in the acid-base nature of tobacco leaf