Low kick sciatic nerve, which is the longest and widest nerve in the human body, beginning in the lower back and running through the buttocks all the way to the lower limb, is a frequent target for low kicks. The most common defense against a low kick is known as "checking", where the leg is bent and brought up to protect the thigh. This causes the kicker to slam their shin into the defending fighters' shin or knee, causing pain and damage to the offender. In some instances, a well executed check of a low kick can break the leg of the
Nerve allograft to bridge the gap is nerve allotransplantation. Nerve allografts are prepared from donated human nerve tissue. An allograft contains many of the beneficial characteristics of nerve autograft, such as three-dimensional microstructural scaffolding and protein components inherent to nerve tissue. One of the adverse effects of nerve allotransplantation is the immunogenic response. Tissue from another human being is used to restore the defect, which can induce an immunogenic response. An immune response against an allograft or xenograft is called Transplant rejection. To prevent this rejection, new immunosuppressive techniques are performed on the graft, before it is transplanted into the receiver. The