Volume as the disk radius, the volume of the sphere can be calculated as Now Combining yields formula_15 This formula can be derived more quickly using the formula for the sphere's surface area, which is formula_16. The volume of the sphere consists of layers of infinitesimally thin spherical shells, and the sphere volume is equal to The cone is a type of pyramidal shape. The fundamental equation for pyramids, one-third times base times altitude, applies to cones as well. However, using calculus, the volume of a cone is the integral of an infinite number of infinitesimally thin circular disks of thickness
Accessible surface area is a numerical method that draws a mesh of points equidistant from each atom of the molecule and uses the number of these points that are solvent accessible to determine the surface area. The points are drawn at a water molecule's estimated radius beyond the van der Waals radius, which is effectively similar to ‘rolling a ball’ along the surface. All points are checked against the surface of neighboring atoms to determine whether they are buried or accessible. The number of points accessible is multiplied by the portion of surface area each point represents to calculate the ASA. The choice