Insect sting allergy potentially something very serious and can lead to anaphylaxis, which is potentially life-threatening. The majority of individuals who receive a sting from an insect experience local reactions. It is estimated that 5-10% of individuals will experience a generalized systemic reaction that can involve symptoms ranging from hives to wheezing and even anaphylaxis. In the United States approximately 40 people die each year from anaphylaxis due to stinging insect allergy. Potentially life-threatening reactions occur in 3% of adults and 0.4–0.8% of children. A 2012 meta-analysis found that venom immunotherapy is an effective prophylactic treatment against insect bite and sting allergic reactions,
Active Life: Extreme Challenge Active Life: Extreme Challenge Active Life: Extreme Challenge (Family Trainer: Extreme Challenge in Europe and Family Trainer 2 in Japan) is a video game for the Wii platform, created by Bandai Namco Games. It is the sequel to "" and was released on August 11, 2009. The game uses a mat to play mini-games. The game-mat is different from the mat that is used in Dance Dance Revolution. As this game's unique pad controller is designed to physically connect to the Wii via its GameCube controller ports, this game is incompatible with later Wii models, which eliminated the said ports.