Burrill Bernard Crohn at Mount Sinai Hospital in 1907. He was promoted to head of gastroenterology in 1920, the same year he joined the staff of Columbia University. Working with colleagues at Mount Sinai Hospital, Crohn identified fourteen patients whose symptoms and intestinal abnormalities discovered at surgery, while consistent with each other, did not fit any previously identified disease. Crohn, along with Leon Ginzburg and Gordon Oppenheimer, prepared the classic paper describing this new condition. This paper was read at a professional meeting in May 1932 and published in the "Journal of the American Medical Association" in October 1932. The title of the
Dent's disease more fully described the disease. Wrong had studied with Dent and chose to name the disease after his mentor. Dent's disease is a genetic disorder caused by mutations in the gene "CLCN5", which encodes a kidney-specific voltage-gated chloride channel, a 746-amino-acid protein (CLC-5) with 12 to 13 transmembrane domains. It manifests itself through low-molecular-weight proteinuria, hypercalciuria, aminoaciduria and hypophosphataemia. Because of its rather rare occurrence, Dent's disease is often diagnosed as idiopathic hypercalciuria, i.e., excess calcium in urine with undetermined causes. Dent's disease Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal