Burrill Bernard Crohn at Mount Sinai Hospital in 1907. He was promoted to head of gastroenterology in 1920, the same year he joined the staff of Columbia University. Working with colleagues at Mount Sinai Hospital, Crohn identified fourteen patients whose symptoms and intestinal abnormalities discovered at surgery, while consistent with each other, did not fit any previously identified disease. Crohn, along with Leon Ginzburg and Gordon Oppenheimer, prepared the classic paper describing this new condition. This paper was read at a professional meeting in May 1932 and published in the "Journal of the American Medical Association" in October 1932. The title of the
Adult polyglucosan body disease shortage (deficiency) of the glycogen branching enzyme, which leads to the production of abnormal glycogen molecules. These abnormal glycogen molecules, called polyglucosan bodies, accumulate within cells and cause damage. Neurons appear to be particularly vulnerable to the accumulation of polyglucosan bodies in people with this disorder, leading to impaired neuronal function. Some mutations in the "GBE1" gene that cause adult polyglucosan body disease do not result in a shortage of glycogen branching enzyme. In people with these mutations, the activity of this enzyme is normal. How mutations cause the disease in these individuals is unclear. Other people with adult polyglucosan