Inflammatory bowel disease inflammatory changes. Crohn's can affect any part of the gastrointestinal tract, from mouth to anus ("skip lesions"), although a majority of the cases start in the terminal ileum. Ulcerative colitis, in contrast, is restricted to the colon and the rectum. Microscopically, ulcerative colitis is restricted to the mucosa (epithelial lining of the gut), while Crohn's disease affects the full thickness of the bowel wall ("transmural lesions"). Lastly, Crohn's disease and ulcerative colitis present with extra-intestinal manifestations (such as liver problems, arthritis, skin manifestations and eye problems) in different proportions. In 10–15% of cases, a definitive diagnosis neither of Crohn's disease
Dieterich's disease or therapy. The cause of Dieterich’s disease is still not fully understood. The disease can afflict patients of any age, but typically affects patients in their 30's. Though rare, it can also occur in children. Statistics show that generally more men are affected by Dieterich's than women in an estimated ratio of 3:2. The third (middle finger) metacarpal head has been reported to be the most common site of necrosis. Though osteonecrosis is a fairly common condition, many cases of avascular necrosis of the metacarpal hand go without being diagnosed. This is because presentation of symptoms is variable depending on