Burrill Bernard Crohn Burrill Bernard Crohn Burrill Bernard Crohn (June 13, 1884 – July 29, 1983) was an American gastroenterologist and made the first major advance to identify the disease that now bears his name. Although the description of Crohn's disease is by far his most famous accomplishment, Crohn had a long career both as a clinician, and as a researcher who contributed to modern understanding of many gastrointestinal conditions. Crohn received his bachelor's degree from City College of New York in 1902. He received a medical degree from Columbia University College of Physicians and Surgeons in 1907. Crohn first became an intern
Dent's disease more fully described the disease. Wrong had studied with Dent and chose to name the disease after his mentor. Dent's disease is a genetic disorder caused by mutations in the gene "CLCN5", which encodes a kidney-specific voltage-gated chloride channel, a 746-amino-acid protein (CLC-5) with 12 to 13 transmembrane domains. It manifests itself through low-molecular-weight proteinuria, hypercalciuria, aminoaciduria and hypophosphataemia. Because of its rather rare occurrence, Dent's disease is often diagnosed as idiopathic hypercalciuria, i.e., excess calcium in urine with undetermined causes. Dent's disease Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal