Laughing Gas (1914 film) Laughing Gas (1914 film) Laughing Gas is a 1914 film starring Charlie Chaplin. The film is also known as Busy Little Dentist, Down and Out, Laffing Gas, The Dentist, and Tuning His Ivories. We are told Charlie is a dental assistant. He arrives at work where the patients are already waiting. He joins the tiny second dental assistant in the back room. They have a brief squabble then Charlie goes to the waiting room to clean the floor with a carpet sweeper. He bumps into a patient and a further squabble starts. Then back to the rear room for more
Substance P nitric oxide release. Substance P is involved in the axon reflex-mediated vasodilatation to local heating and wheal and flare reaction. It has been shown that vasodilatation to substance P is dependent on the NK1 receptor located on the endothelium. In contrast to other neuropeptides studied in human skin, substance P-induced vasodilatation has been found to decline during continuous infusion. This possibly suggests an internalization of neurokinin-1 (NK1). As is typical with many vasodilators, it also has bronchoconstrictive properties, administered through the non-adrenergic, non-cholinergic nervous system (branch of the vagal system). SP initiates expression of almost all known immunological chemical messengers