Helenus found the city of Buthrotum. After Neoptolemus left Epirus, he left Andromache and their sons in Helenus's care. Neoptolemus was killed by Orestes, Agamemmon's son, in dispute over Hermione, the daughter of Menelaus and Helen, whom Orestes had been promised as wife, but whom Neoptolemus had taken. As the kingdom of Neoptolemus was partitioned, this led to Helenus acquiring the rule of Buthrotum, as king. "Helenus, a son of Priam, was king over these Greek cities of Epirus, having succeeded to the throne and bed of Neoptolemus." Andromache bore him a son, Cestrinus, who is identified with Genger or Zenter,
Classical Anatolia and was appointed to be the local satrap as had been his father Orontes II (336–331 BC). With the death of Alexander and subsequent division of the empire in 323 BC, Armenia was granted to Neoptolemus (323–321 BC). Neoptolemus, however, conspired and was killed in battle with Eumenes in 321 BC. With the subsequent fall of Eumenes, Mithrenes re-assumed power (321–317 BC) and declared himself king. He was succeeded by Orontes III (317–260 BC) and relative stability apart from his unsuccessful struggles with the minor kingdom of Sophene on his south-western frontier. During this time the capital was moved from