Solid angle a solid angle in steradians is the following ratio: where A is the spherical surface area and r is the radius of the considered sphere. Solid angles are often used in physics, in particular astrophysics. The solid angle of an object that is very far away is roughly proportional to the ratio of area to squared distance. Here "area" means the area of the object when projected along the viewing direction. The solid angle of a sphere measured from any point in its interior is 4 sr, and the solid angle subtended at the center of a cube by one
Polar surface area usually needed. Polar surface area The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared tend to be poor at permeating cell membranes. For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 angstroms