Japanese Paleolithic are a technology associated in the rest of the world with the beginning of the Neolithic around 10,000 BC. It is not known why such tools were created so early in Japan. Because of this originality, the Japanese Paleolithic period in Japan does not exactly match the traditional definition of Paleolithic based on stone technology (chipped stone tools). Japanese Paleolithic tool implements thus display Mesolithic and Neolithic traits as early as 30,000 BC. The Paleolithic populations of Japan, as well as the later Jōmon populations, appear to relate to an ancient Paleo-Asian group which occupied large parts of Asia before
Lithium (medication) the likelihood of developing depression. People taking lithium thus should routinely be assessed for hypothyroidism and treated with synthetic thyroxine if necessary. Because lithium competes with the receptors for the antidiuretic hormone in the kidney, it increases water output into the urine, a condition called nephrogenic diabetes insipidus. Clearance of lithium by the kidneys is usually successful with certain diuretic medications, including amiloride and triamterene. It increases the appetite and thirst ("polydypsia") and reduces the activity of thyroid hormone (hypothyroidism). The latter can be corrected by treatment with thyroxine and does not require the lithium dose to be adjusted. Lithium