Meg Ryan roles followed, including appearances in "Charles in Charge", "Armed and Dangerous", "Amityville 3-D" and "Promised Land"; for her role in the lattermost she received her first Independent Spirit Award nomination. In 1986, she played Carole Bradshaw, the wife of Naval Flight Officer Nick "Goose" Bradshaw (played by Anthony Edwards) in "Top Gun". Ryan appeared in the film "Innerspace" (1987) with her future husband Dennis Quaid, and later in the remake of "D.O.A." (1988) and in "The Presidio" (1988). Her first leading role was the romantic comedy film "When Harry Met Sally..." (1989), which paired her with comedic leading man Billy
Orgasm while there is no change or increased metabolic activity in the limbic (i.e., "bordering") areas of the brain. There is also a wide range of sexual dysfunctions, such as anorgasmia. These effects impact cultural views of orgasm, such as the beliefs that orgasm and the frequency/consistency of it are either important or irrelevant for satisfaction in a sexual relationship, and theories about the biological and evolutionary functions of orgasm. Orgasm in non-human animals has been studied significantly less than orgasm in humans, but research on the subject is ongoing. In a clinical context, orgasm is usually defined strictly by the