Characters in Hamlet He is the courtier sent by Claudius to invite Hamlet to participate in the duel with Laertes. (This character is called "Ostricke" in the Second Quarto.) Osric, as well as Polonius, attempts to engage with Hamlet in the elaborate, witty discourse, fully consistent with Baldassare Castiglione's 1528 work, "The Courtier". This work outlines several courtly rules, specifically advising royal retainers to amuse their masters with inventive language. The Players are a company of actors who arrive at Elsinore Castle. Friends of Hamlet, they had earlier performed in "the city" (presumably Copenhagen), but faced stiff competition from boy performers, so they
HAMLET (protein complex) has never before been demonstrated for any protein. However, proteasome inhibition alone does not seem to be responsible for HAMLET-induced cell death, as proteasome inhibitors have been shown to reduce the cytotoxicity of HAMLET. HAMLET also targets the nucleus, where it interacts with histones to interfere with transcriptional processes. Studies have shown that HAMLET is mostly localized to the nucleus within one hour of invading a tumor cell. Hamlet has been shown to bind with high affinity to individual histone proteins, to be specific H2a, H2b, H3, and H4, as well as entire nucleosomal units. This interaction irreversibly blocks transcription