Surface of revolution never negative, the area is given by If the curve is described by the function , , then the integral becomes for revolution around the -axis, and for revolution around the "y"-axis (using ). These come from the above formula. For example, the spherical surface with unit radius is generated by the curve , , when ranges over . Its area is therefore For the case of the spherical curve with radius , rotated about the -axis A minimal surface of revolution is the surface of revolution of the curve between two given points which minimizes surface area. A basic
Polar surface area usually needed. Polar surface area The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared tend to be poor at permeating cell membranes. For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 angstroms