Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
What Is Life Harrison performances" (just three of which date from the ex-Beatle's solo years) and described the track as an "exultant song of surrender", abetted by Harrison's "pumping fuzz guitar" and the song's "singalong magnetism". AllMusic's Richie Unterberger similarly praises "What Is Life" for its "anthemic" qualities, "particularly snazzy horn lines", and a guitar riff that is "one more entry in the catalog of George Harrison's book of arresting, low, descending guitar lines". Writing in the book "1,000 Recordings to Hear Before You Die", author Tom Moon refers to "the upbeat single 'What Is Life'" as an example of how Harrison "grabs