Surface area in the study of fractals. Extensions of the notion of area which partially fulfill its function and may be defined even for very badly irregular surfaces are studied in geometric measure theory. A specific example of such an extension is the Minkowski content of the surface. The below given formulas can be used to show that the surface area of a sphere and cylinder of the same radius and height are in the ratio 2 : 3, as follows. Let the radius be "r" and the height be "h" (which is 2"r" for the sphere). formula_7 The discovery of this
Polar surface area usually needed. Polar surface area The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared tend to be poor at permeating cell membranes. For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 angstroms