Absolute dating radiocarbon dating. The development of accelerator mass spectrometry (AMS) dating, which allows a date to be obtained from a very small sample, has been very useful in this regard. Other radiometric dating techniques are available for earlier periods. One of the most widely used is potassium–argon dating (K–Ar dating). Potassium-40 is a radioactive isotope of potassium that decays into argon-40. The half-life of potassium-40 is 1.3 billion years, far longer than that of carbon-14, allowing much older samples to be dated. Potassium is common in rocks and minerals, allowing many samples of geochronological or archeological interest to be dated. Argon,
Kinetic isotope effect reach the transition state (or, in rare cases, the dissociation limit), and consequently, a slower reaction rate. The study of kinetic isotope effects can help the elucidation of the reaction mechanism of certain chemical reactions and is occasionally exploited in drug development to improve unfavorable pharmacokinetics by protecting metabolically-vulnerable C-H bonds. The kinetic isotope effect is considered to be one of the most essential and sensitive tools for the study of reaction mechanisms, the knowledge of which allows the improvement of the desirable qualities of the corresponding reactions. For example, kinetic isotope effects can be used to reveal whether a