Roca dels Bous (archaeological site) interesting archaeological site indeed. Furthermore, it is to be noted that the samples used for the 14C AMS dating were obtained from deep strata at the site. The oldest Neanderthal sites known in the nearby areas date back to around 40,000 BP. The first settlements attributed to “anatomically modern” Homo sapiens sapiens in Northern Spain are dated around 39,000-38,000 BP. All this would suggest that Neanderthals could have persisted in this particular area longer than previously believed, preceding the arrival of the first Homo sapiens to the area. Research work began in 1988. This wide period of time has contributed
Isotope-coded affinity tag of the column. For the quantitative comparison of two proteomes, one sample is labeled with the isotopically light (d0) probe and the other with the isotopically heavy (d8) version. To minimize error, both samples are then combined, digested with a protease (i.e., trypsin), and subjected to avidin affinity chromatography to isolate peptides labeled with isotope-coded tagging reagents. These peptides are then analyzed by liquid chromatography-mass spectrometry (LC-MS). The ratios of signal intensities of differentially mass-tagged peptide pairs are quantified to determine the relative levels of proteins in the two samples. Isotope-coded affinity tag An Isotope-coded affinity tag (ICAT) is an