Amblyomma americanum mammalian meat and meat products. The allergy manifests as anaphylaxis — a life-threatening allergic reaction characterized by constriction of airways and a drop in blood pressure. This response is triggered by an IgE antibody to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). As well as occurring in non-primate mammals, alpha-gal is also found in cat dander and in the drug cetuximab. Allergic reactions to alpha-gal usually occur 3–6 hours after consuming red meat, unlike allergic reactions to other foods, whose onset following consumption is more or less immediate, making it more difficult to identify what caused the reaction. Skin tests with standard
Active Life: Extreme Challenge Active Life: Extreme Challenge Active Life: Extreme Challenge (Family Trainer: Extreme Challenge in Europe and Family Trainer 2 in Japan) is a video game for the Wii platform, created by Bandai Namco Games. It is the sequel to "" and was released on August 11, 2009. The game uses a mat to play mini-games. The game-mat is different from the mat that is used in Dance Dance Revolution. As this game's unique pad controller is designed to physically connect to the Wii via its GameCube controller ports, this game is incompatible with later Wii models, which eliminated the said ports.