Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
What Is Life about it …" In September 2014, this instrumental version also appeared as a bonus track on the 2014 "Apple Years 1968–75" reissue of "All Things Must Pass".<ref name="Marchese/SecondDisc">Joe Marchese, "Give Me Love: George Harrison’s 'Apple Years' Are Collected On New Box Set", The Second Disc, 2 September 2014 (retrieved 26 September 2014).</ref> Coinciding with the release, Harrison's widow and son, Olivia and Dhani, held an online competition in which filmmakers were invited to create a video clip for "What Is Life". The winner received a $5000 cash prize and their entry became the official video for the track, appearing on