Spanish East Indies chief consort, and his subjects. Seeking to develop trade between the East Indies and the Americas across the Pacific Ocean, Antonio de Mendoza encouraged the exploration of these Asian territories and commissioned the expedition of Ruy López de Villalobos to the Philippines in 1542–1543. Miguel López de Legazpi set out from Mexico, and established the first Spanish settlement in the Philippines in 1565, which became the town of San Miguel in present-day Cebu. That same year, another member of the expedition, Andrés de Urdaneta discovered a maritime route from the Philippines to Mexico, across the Pacific, leading to the important
Spanish West Indies Dominican Republic; Cuba, Puerto Rico, Saint Martin, the Virgin Islands, Anguilla, Montserrat, Guadalupe and the Lesser Antilles, Jamaica, the Cayman Islands, Venezuela (Margarita island), Trinidad, and the Bay Islands. The islands that later became the Spanish West Indies were the focus of the voyages of Christopher Columbus in America. Largely due to the familiarity that Europeans gained from Columbus's voyages, the islands were also the first lands to be permanently colonized by Europeans in the Americas. The Spanish West Indies were also the most enduring part of Spain's American Empire, only being surrendered in 1898 at the end of the