Surface area representing a cell as an idealized sphere of radius "r", the volume and surface area are, respectively, "V" = 4/3 π "r"; "SA" = 4 π "r". The resulting surface area to volume ratio is therefore 3/"r". Thus, if a cell has a radius of 1 μm, the SA:V ratio is 3; whereas if the radius of the cell is instead 10 μm, then the SA:V ratio becomes 0.3. With a cell radius of 100, SA:V ratio is 0.03. Thus, the surface area falls off steeply with increasing volume. Surface area The surface area of a solid object is a
Accessible surface area is a numerical method that draws a mesh of points equidistant from each atom of the molecule and uses the number of these points that are solvent accessible to determine the surface area. The points are drawn at a water molecule's estimated radius beyond the van der Waals radius, which is effectively similar to ‘rolling a ball’ along the surface. All points are checked against the surface of neighboring atoms to determine whether they are buried or accessible. The number of points accessible is multiplied by the portion of surface area each point represents to calculate the ASA. The choice