Japanese Paleolithic are a technology associated in the rest of the world with the beginning of the Neolithic around 10,000 BC. It is not known why such tools were created so early in Japan. Because of this originality, the Japanese Paleolithic period in Japan does not exactly match the traditional definition of Paleolithic based on stone technology (chipped stone tools). Japanese Paleolithic tool implements thus display Mesolithic and Neolithic traits as early as 30,000 BC. The Paleolithic populations of Japan, as well as the later Jōmon populations, appear to relate to an ancient Paleo-Asian group which occupied large parts of Asia before
Lithium (medication) is also believed to permanently affect renal function, although this does not appear to be common. Lithium is a teratogen, causing birth defects in a small number of newborn babies. Case reports and several retrospective studies have demonstrated possible increases in the rate of a congenital heart defect known as Ebstein's anomaly, if taken during a woman's pregnancy. As a consequence, fetal echocardiography is routinely performed in pregnant women taking lithium to exclude the possibility of cardiac anomalies. Lamotrigine seems to be a possible alternative to lithium in pregnant women for the treatment of acute bipolar depression or for the