Solid angle orientation formula_9, and distance from the viewer as: where the surface area of a sphere is . The solid angle of a cone with its apex at the apex of the solid angle, and with apex angle 2, is the area of a spherical cap on a unit sphere For small such that , this reduces to the area of a circle . The above is found by computing the following double integral using the unit surface element in spherical coordinates: This formula can also be derived without the use of calculus. Over 2200 years ago Archimedes proved that the
Polar surface area Polar surface area The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared tend to be poor at permeating cell membranes. For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 angstroms squared is