Earl of Salisbury later by Richard Neville "the Kingmaker", upon whose death the title went into abeyance because multiple individuals were entitled to inherit it. Then, in 1472, it was granted to George, Duke of Clarence, who was married to Warwick's eldest daughter. When the Duke of Clarence was executed in 1478 for treason (supposedly by being drowned in a vat of Malmsey wine), the title was forfeit. It was then granted to Edward of Middleham (who was his nephew via the Duke's brother Richard), who died in 1484 at the age of 11. It was restored to two of George of Clarence's
Isleños in Louisiana Canary Islands. With the crisis occasioned by the collapse of the trade in the Canarian "malvasia" wine (called "malmsey" in England) in the 18th century, there was an increase in poverty. Beginning in the late 1700s, prickly pear cactuses were grown in the Canary Islands to serve as hosts plants for cochineal insects from which the dye carmine was made. It became a major export of the islands in its own right, but this trade collapsed in its turn after the dye began to be produced synthetically in Europe. Most of the affected people were farmers and laborers who had