Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
What Is Life "Close to the Edge", "Mojo", December 2003, p. 82.</ref> It was while driving up to a Preston session in London from his home in Esher, Surrey, that Harrison came up with the song "What Is Life". In his autobiography, "I, Me, Mine", Harrison describes it as having been written "very quickly" and recalls that he thought it would be a perfect, "catchy pop song" for Preston to record. His lyrics, while simple, were similarly uplifting and universal: These lyrics have caused some debate among biographers and music critics, as to whether "What Is Life" should be viewed as a straightforward