Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
What Is Life a combination that became the top-selling single of 1971 in that country. "What Is Life" is one of Harrison's most commercial and popular songs – a "spiritual guitar quest" that "became [a] classic", according to "Rolling Stone" magazine. On release, "Billboard" magazine's reviewer wrote of "What Is Life" and "Apple Scruffs" as "intriguing rhythm follows-ups" to Harrison's previous single, which were "sure to repeat that success" and "should prove big juke box items". In their "Solo Beatles Compendium", authors Chip Madinger and Mark Easter refer to it as an "intensely catchy track" and view its pairing with "My Sweet Lord"