Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
What Is Life During the verses, Gordon moves to a square, Motown-style beat – or "rock-steady Northern soul backbeat" in Leng's words – before returning to the "galloping rhythm" of the more open, "knockout" choruses, and the song is driven equally by Badfinger drummer Mike Gibbins' powerful tambourine work. On "What Is Life", Spector provided what music critic David Fricke terms "echo-drenched theater", in the form of reverb-heavy brass, soaring strings (arranged by John Barham) and "a choir of multitracked Harrisons". The vocals and Barham's contribution, along with a brief slide-guitar commentary from Harrison over the final verse, were overdubbed at Trident Studios,