Laertes (Hamlet) match begins, Hamlet apologises publicly to Laertes for the wrongs he has dealt him. Laertes accepts the apology, so he says, but he proceeds with the scheme to kill Hamlet (though after Gertrude drinks the poisoned drink he expresses having an attack of conscience). Hamlet is eventually wounded with the poisoned sword. Then, in a scuffle, the swords are switched. Hamlet wounds Laertes with his own poisoned blade, and Laertes then falls as well. Only then does he truly seem to feel guilty, for he tells Osric he has been "justly killed" with his own treachery. As he lies dying,
HAMLET (protein complex) has never before been demonstrated for any protein. However, proteasome inhibition alone does not seem to be responsible for HAMLET-induced cell death, as proteasome inhibitors have been shown to reduce the cytotoxicity of HAMLET. HAMLET also targets the nucleus, where it interacts with histones to interfere with transcriptional processes. Studies have shown that HAMLET is mostly localized to the nucleus within one hour of invading a tumor cell. Hamlet has been shown to bind with high affinity to individual histone proteins, to be specific H2a, H2b, H3, and H4, as well as entire nucleosomal units. This interaction irreversibly blocks transcription