Estelle Reiner Harry Met Sally...", in which director Rob Reiner cast his mother as a customer in a scene with stars Billy Crystal and Meg Ryan at Katz's Delicatessen, in which Ryan fakes what was described as "a very public (and very persuasive) orgasm". Approached by a waitress after Ryan finishes, Reiner deadpans "I’ll have what she’s having". The line was ranked 33rd on the American Film Institute's list of the Top 100 movie quotations, just behind "Casablanca"'s "Round up the usual suspects". Reiner died of natural causes on October 25, 2008 at age 94 in her home in Beverly Hills, California.
Orgasm correlating orgasm and brain activity in real time. One study examined 12 healthy women using a positron emission tomography (PET) scanner while they were being stimulated by their partners. Brain changes were observed and compared between states of rest, sexual stimulation, faked orgasm, and actual orgasm. Differences were reported in the brains of men and women during stimulation. However, changes in brain activity were observed in both sexes in which the brain regions associated with behavioral control, fear and anxiety shut down. Regarding these changes, Gert Holstege said in an interview with "The Times", "What this means is that deactivation,