Spanish East Indies together with the Spanish West Indies, were administered through the Viceroyalty of New Spain based in Mexico City. After Mexican independence, they were ruled directly from Madrid. As a result of the Spanish–American War in 1898, the Philippines and Guam were occupied by the United States while about 6,000 of the remaining smaller islands were sold to Germany in the German–Spanish Treaty of 1899. The few remaining islands were ceded to the United States when the Treaty of Washington was ratified in 1901. Spanish contact began on , when a Spanish expedition led by Ferdinand Magellan reached the Mariana Islands.
Spanish West Indies closely tied to the Spanish Caribbean. During the period of Spanish settlement and colonization of the New World, the Spanish West Indies referred to those settlements in islands of the Caribbean Sea under political administration of Spain, as in the phrase "a 1765 cedula authorized seven sea ports, in addition to the port of San Juan, to trade with the Spanish Caribbean." Until the early 19th century these territories were part of the Viceroyalty of New Spain. In a modern sense, the Caribbean islands of Venezuela and those of Colombia could be included in the Hispanophone Caribbean as well, due