Meg Ryan Crystal and earned her a Golden Globe nomination. Her portrayal of Sally Albright includes an oft-recounted scene in which her character, lunching with Crystal in Katz's Delicatessen in Manhattan, theatrically demonstrates for him how easy it is for a woman to fake an orgasm. Ryan next starred in "The Doors", which was moderately successful, and "Prelude to a Kiss", which flopped. The year 1993 saw the release of the hugely successful romantic comedy "Sleepless in Seattle", which paired Ryan for a second time with Tom Hanks. They had previously been paired as romantic leads in the film "Joe Versus the
Orgasm correlating orgasm and brain activity in real time. One study examined 12 healthy women using a positron emission tomography (PET) scanner while they were being stimulated by their partners. Brain changes were observed and compared between states of rest, sexual stimulation, faked orgasm, and actual orgasm. Differences were reported in the brains of men and women during stimulation. However, changes in brain activity were observed in both sexes in which the brain regions associated with behavioral control, fear and anxiety shut down. Regarding these changes, Gert Holstege said in an interview with "The Times", "What this means is that deactivation,