Estelle Reiner Harry Met Sally...", in which director Rob Reiner cast his mother as a customer in a scene with stars Billy Crystal and Meg Ryan at Katz's Delicatessen, in which Ryan fakes what was described as "a very public (and very persuasive) orgasm". Approached by a waitress after Ryan finishes, Reiner deadpans "I’ll have what she’s having". The line was ranked 33rd on the American Film Institute's list of the Top 100 movie quotations, just behind "Casablanca"'s "Round up the usual suspects". Reiner died of natural causes on October 25, 2008 at age 94 in her home in Beverly Hills, California.
Orgasm while there is no change or increased metabolic activity in the limbic (i.e., "bordering") areas of the brain. There is also a wide range of sexual dysfunctions, such as anorgasmia. These effects impact cultural views of orgasm, such as the beliefs that orgasm and the frequency/consistency of it are either important or irrelevant for satisfaction in a sexual relationship, and theories about the biological and evolutionary functions of orgasm. Orgasm in non-human animals has been studied significantly less than orgasm in humans, but research on the subject is ongoing. In a clinical context, orgasm is usually defined strictly by the