Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
Active Life: Extreme Challenge Active Life: Extreme Challenge Active Life: Extreme Challenge (Family Trainer: Extreme Challenge in Europe and Family Trainer 2 in Japan) is a video game for the Wii platform, created by Bandai Namco Games. It is the sequel to "" and was released on August 11, 2009. The game uses a mat to play mini-games. The game-mat is different from the mat that is used in Dance Dance Revolution. As this game's unique pad controller is designed to physically connect to the Wii via its GameCube controller ports, this game is incompatible with later Wii models, which eliminated the said ports.