Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
What Is Life? his 1922 article "Variation due to Change in the Individual Gene" already laid out all the basic properties of the "heredity molecule" (then not yet known to be DNA) that Schrödinger was to re-derive in 1944 "from first principles" in "What is Life?" (including the "aperiodicity" of the molecule), properties which Muller specified and refined additionally in his 1929 article "The Gene As The Basis of Life" and during the 1930s. Moreover, H. J. Muller himself wrote in a 1960 letter to a journalist regarding "What Is Life?" that whatever the book got right about the "hereditary molecule" had already