Omalizumab and the World Health Organization. It is also used to treat people 12 years and above with chronic spontaneous urticaria (also called chronic idiopathic urticaria), which cannot be treated with elevated doses of H1-antihistamines. The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 patients per 1,000. Like other protein and antibody drugs, omalizumab also causes anaphylaxis, although at a relatively low frequency among antibody drugs. The allergic reaction is probably not due to the binding characteristics of the antibody drug, but to the protein nature of the antibody. The
Henna a person has had a black henna tattoo and later dyes their hair with chemical hair dye, the allergic reaction may be life-threatening and require hospitalization. Because of the epidemic of PPD allergic reactions, chemical hair dye products now post warnings on the labels: "Temporary black henna tattoos may increase your risk of allergy. Do not colour your hair if: ... – you have experienced a reaction to a temporary black henna tattoo in the past." PPD is illegal for use on skin in western countries, though enforcement is difficult. Physicians have urged governments to legislate against black henna because