Lee Mack comedy was doing Bobby Ball impressions at his school when he was 15. Mack is a keen supporter of Blackburn Rovers and occasionally visits Ewood Park to watch games. At one point, Mack shared a flat with Noel Fielding. In July 2012, Mack received an honorary doctorate from Brunel University. He published his autobiography "Mack the Life" () in the same year. In 2012, Mack was diagnosed with attention deficit hyperactivity disorder. Mack is a darts fan and regularly plays with his friend Tim Vine. Both men appeared on the debut series of "Let's Play Darts", facing each other in
Lee Mack Hancock. However, it proved to be the show's final series. In 2007 he appeared on "TV Heaven, Telly Hell". His first sitcom "Not Going Out" for BBC One with Tim Vine (in which he plays Lee, the central character) premiered on 6 October 2006. The show has since returned for eight more series, the most recent airing in 2018. The show has won a Rose d'Or and RTS Award. Since 2007, Mack has been a team captain on the BBC One comedy panel show "Would I Lie to You?". He has also been guest host on "Have I Got News