Volume as the disk radius, the volume of the sphere can be calculated as Now Combining yields formula_15 This formula can be derived more quickly using the formula for the sphere's surface area, which is formula_16. The volume of the sphere consists of layers of infinitesimally thin spherical shells, and the sphere volume is equal to The cone is a type of pyramidal shape. The fundamental equation for pyramids, one-third times base times altitude, applies to cones as well. However, using calculus, the volume of a cone is the integral of an infinite number of infinitesimally thin circular disks of thickness
Polar surface area usually needed. Polar surface area The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared tend to be poor at permeating cell membranes. For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 angstroms