Solid angle to the unit sphere with center P, which can be calculated as the surface integral: where formula_5 is the unit vector corresponding to formula_6, the position vector of an infinitesimal area of surface with respect to point P, and where formula_7 represents the unit normal vector to . Even if the projection on the unit sphere to the surface S is not isomorphic, the multiple folds are correctly considered according to the surface orientation described by the sign of the scalar product formula_8. Thus one can approximate the solid angle subtended by a small facet having flat surface area ,
Accessible surface area is a numerical method that draws a mesh of points equidistant from each atom of the molecule and uses the number of these points that are solvent accessible to determine the surface area. The points are drawn at a water molecule's estimated radius beyond the van der Waals radius, which is effectively similar to ‘rolling a ball’ along the surface. All points are checked against the surface of neighboring atoms to determine whether they are buried or accessible. The number of points accessible is multiplied by the portion of surface area each point represents to calculate the ASA. The choice