Allergic reactions to anaesthesia giving false positive and false negative results. Although complications during anaesthesia are rare, potentially life-threatening consequences may occur if an anaphylactic reaction develops. The severity of the reaction whilst under anaesthesia is because the anaesthetist is only made aware of the allergy when it is severe enough to compromise the cardiovascular system and the respiratory system. At this stage, there is little time to manage the situation and recognise the severity of the condition. The immediate management of the issue consists of three processes: Since the full withdrawal of the offending substance is near impossible, the administration of adrenalin is
Mazzotti reaction Mazzotti reaction The Mazzotti reaction, first described in 1948, is a symptom complex seen in patients after undergoing treatment of onchocerciasis with the medication diethylcarbamazine (DEC). Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and abdominal pain that occur within seven days of treatment of microfilariasis. The Mazzotti reaction correlates with intensity of infection; however, there are probably multiple infection intensity-dependent mechanisms responsible for mediating this complex reaction. The phenomenon is so common when DEC is used for the treatment of onchocerciasis that this drug is the basis