Spanish East Indies exception of a short period at the end of the 18th century). In 1821 the New Spanish Viceroyalty collapsed following the Mexican War of Independence, which resulted in the First Mexican Empire. All control of the Spanish East Indies government was then transferred to Madrid, until the United States annexed most Spanish territories in the Asia-Pacific region after the Spanish–American War of 1898. In 1574 the Captaincy General of the Philippines was created as a dependency of the Viceroyalty of New Spain. The Real Audiencia of Manila was created on and established in 1584 as the highest tribunal of the
Spanish West Indies Dominican Republic; Cuba, Puerto Rico, Saint Martin, the Virgin Islands, Anguilla, Montserrat, Guadalupe and the Lesser Antilles, Jamaica, the Cayman Islands, Venezuela (Margarita island), Trinidad, and the Bay Islands. The islands that later became the Spanish West Indies were the focus of the voyages of Christopher Columbus in America. Largely due to the familiarity that Europeans gained from Columbus's voyages, the islands were also the first lands to be permanently colonized by Europeans in the Americas. The Spanish West Indies were also the most enduring part of Spain's American Empire, only being surrendered in 1898 at the end of the