Chimera (Barth novel) Chimera (Barth novel) Chimera is a 1972 fantasy novel written by American writer John Barth, composed of three loosely connected novellas. The novellas are "Dunyazadiad", "Perseid" and "Bellerophoniad", whose titles refer eponymously to the mythical characters Dunyazad, Perseus and Bellerophon (slayer of the mythical Chimera). The book is an example of postmodernism, which can be seen in its metafictional content and its incorporation of stylistic elements that go beyond the traditional novel genre. It shared the U.S. National Book Award for Fiction with "Augustus" by John Edward Williams. The Dunyazadiad is a retelling of the framing story of Scheherazade, the
Zinc finger chimera Zinc finger chimera Zinc finger protein chimera are chimeric proteins composed of a DNA-binding zinc finger protein domain and another domain through which the protein exerts its effect. The effector domain may be a transcriptional activator (A) or repressor (R), a methylation domain (M) or a nuclease (N). Modification of the endogenous DNA-binding zinc finger domain is the basis of the most advanced field in construction of gene-specific artificial transcription factors. Linking together six ZFPs produces a target-site of 18-19 bp. Assuming specificity to that one sequence and that the sequence of the genome is random, 18 bp is long