Skeleton intervertebral discs. It is not as hard and rigid as bone but is stiffer and less flexible than muscle. Cartilage is composed of specialized cells called chondrocytes that produce a large amount of extracellular matrix composed of Type II collagen (except Fibrocartilage which also contains type I collagen) fibers, abundant ground substance rich in proteoglycan, and elastin fibers. Cartilage is classified in three types, elastic cartilage, hyaline cartilage and fibrocartilage, which differ in the relative amounts of these three main components. Unlike other connective tissues, cartilage does not contain blood vessels. The chondrocytes are supplied by diffusion, helped by the
Hyaline cartilage cavities in the matrix, called cartilage lacunæ. These cavities are actually artificial gaps formed from the shrinking of the cells during the staining and setting of the tissue for examination. The inter-territorial space between the isogenous cell groups contains relatively more collagen fibres, allowing it to maintain its shape while the actual cells shrink, creating the lacunae. This constitutes the so-called 'capsule' of the space. Each lacuna is usually occupied by a single cell, but during mitosis, it may contain two, four, or even eight cells. Articular cartilage is hyaline cartilage on the articular surfaces of bones, and lies inside