Laughing Gas (instrumental) Laughing Gas (instrumental) "Laughing Gas" was a song performed by Quiet Riot at all the live performances while Randy Rhoads played with the band. It was never recorded onto an album until a live bootleg performance was enhanced (with rerecorded vocals) and placed on "The Randy Rhoads Years". The improvised solo was just over 6 minutes long and contained clips from future songs of Ozzy Osbourne including, "Goodbye to Romance", "Mr. Crowley", "Dee", and "Crazy Train". The solo outlined Randy's talent and productivity level at such a young age. This solo also contained a reference to William Tell Overture and
Substance P nitric oxide release. Substance P is involved in the axon reflex-mediated vasodilatation to local heating and wheal and flare reaction. It has been shown that vasodilatation to substance P is dependent on the NK1 receptor located on the endothelium. In contrast to other neuropeptides studied in human skin, substance P-induced vasodilatation has been found to decline during continuous infusion. This possibly suggests an internalization of neurokinin-1 (NK1). As is typical with many vasodilators, it also has bronchoconstrictive properties, administered through the non-adrenergic, non-cholinergic nervous system (branch of the vagal system). SP initiates expression of almost all known immunological chemical messengers