Meg Ryan roles followed, including appearances in "Charles in Charge", "Armed and Dangerous", "Amityville 3-D" and "Promised Land"; for her role in the lattermost she received her first Independent Spirit Award nomination. In 1986, she played Carole Bradshaw, the wife of Naval Flight Officer Nick "Goose" Bradshaw (played by Anthony Edwards) in "Top Gun". Ryan appeared in the film "Innerspace" (1987) with her future husband Dennis Quaid, and later in the remake of "D.O.A." (1988) and in "The Presidio" (1988). Her first leading role was the romantic comedy film "When Harry Met Sally..." (1989), which paired her with comedic leading man Billy
Meg Ryan Jackie Kallen, the first woman to become a success in the sport. The film grossed less than $6 million in the U.S. and was panned by critics, in part because of its resemblance to other boxing films, such as the "Rocky" series. Following a three-year hiatus, Ryan returned to film with Jon Kasdan's 2007 independent film "In the Land of Women", a film she described as "kind of like "The Graduate", but with cancer". Starring alongside Kristen Stewart and Olympia Dukakis, she played Sarah Hardwicke, a mother and wife facing breast cancer, who connects with her neighbor's much younger grandson,