Spanish East Indies together with the Spanish West Indies, were administered through the Viceroyalty of New Spain based in Mexico City. After Mexican independence, they were ruled directly from Madrid. As a result of the Spanish–American War in 1898, the Philippines and Guam were occupied by the United States while about 6,000 of the remaining smaller islands were sold to Germany in the German–Spanish Treaty of 1899. The few remaining islands were ceded to the United States when the Treaty of Washington was ratified in 1901. Spanish contact began on , when a Spanish expedition led by Ferdinand Magellan reached the Mariana Islands.
Spanish West Indies Dominican Republic; Cuba, Puerto Rico, Saint Martin, the Virgin Islands, Anguilla, Montserrat, Guadalupe and the Lesser Antilles, Jamaica, the Cayman Islands, Venezuela (Margarita island), Trinidad, and the Bay Islands. The islands that later became the Spanish West Indies were the focus of the voyages of Christopher Columbus in America. Largely due to the familiarity that Europeans gained from Columbus's voyages, the islands were also the first lands to be permanently colonized by Europeans in the Americas. The Spanish West Indies were also the most enduring part of Spain's American Empire, only being surrendered in 1898 at the end of the