BCG vaccine fine powder. Sometimes the powder is sealed with vacuum in a glass ampoule. Such a glass ampoule has to be opened slowly to prevent the airflow from blowing out the powder. Then the powder has to be diluted with saline water before injecting. The history of BCG is tied to that of smallpox. Jean Antoine Villemin first recognized bovine tuberculosis in 1854 and transmitted it, and Robert Koch first distinguished "Mycobacterium bovis" from "Mycobacterium tuberculosis". Following the success of vaccination in preventing smallpox, established during the 18th century, scientists thought to find a corollary in tuberculosis by drawing a parallel
Inoculation theory counterarguments, the inoculation receiver will then seek out supporting information to further strengthen their threatened position. Finally, the held attitude or belief becomes resistant to a stronger attack, hence the medical analogy of a vaccine. Inoculation is a theory developed to strengthen existing attitudes and beliefs while building resistance to future counterarguments. For inoculation to be successful it is crucial that a threat (motivation for resistance) is imposed upon these existing ideas and refutational preemption (ability to build defenses against potential counterarguments) takes place after the inoculation. The argument that is presented through inoculation must be strong enough to initiate