Isotopes of iodine and non-radioactive materials can be described as "cold." There are instances in which cold iodide is administered to people in order to prevent the uptake of hot iodide by the thyroid gland. For example, blockade of thyroid iodine uptake with potassium iodide is used in nuclear medicine scintigraphy and therapy with some radioiodinated compounds that are not targeted to the thyroid, such as iobenguane (MIBG), which used to image or treat neural tissue tumors, or iodinated fibrinogen, which is used in fibrinogen scans to investigate clotting. These compounds contain iodine, but not in the iodide form. However, since they may
Isotopes of iodine and 1970s reached about 10). I differs from Cl in that its half-life is longer (15.7 vs. 0.301 million years), it is highly biophilic, and occurs in multiple ionic forms (commonly, I and IO), which have different chemical behaviors. This makes it fairly easy for I to enter the biosphere as it becomes incorporated into vegetation, soil, milk, animal tissue, etc. Of the many isotopes of iodine, only two are typically used in a medical setting: iodine-123 and iodine-131. Since I has both a beta and gamma decay mode, it can be used for radiotherapy or for imaging. I, which