Julio-Claudian dynasty reign as being strongly influenced by his mother Agrippina, his tutor Seneca, and the Praetorian Prefect Burrus, especially in the first year. He was made Emperor over his step-brother, Claudius' son Britannicus, who he had killed. Agrippina was believed to have poisoned Claudius, having allegedly poisoned her second husband Gaius Sallustius Crispus Passienus. She had also arranged the deaths of Caligula's third wife, Lollia Paulina and Messalina's mother Domitia Lepida the Younger. She saw that the dynasty's numbers dwindle with the execution of Marcus Junius Silanus Torquatus, a grandson of Julia the Younger, to strengthen Nero's claim, having previously arranged
Vipsania Agrippina and lived an unhappy long life. Pomponia married Aulus Plautius. Plautius was a general in the conquest of Britain, which he received as a military ovation. Nero murdered their son, reportedly because Agrippina the Younger, mother of Nero, was in love with him and encouraged him to bid for the throne. Another descendant or otherwise relative, Gaius Asinius Lepidus Praetextatus (210 – after 242), became a Consul in 242, being the son of Gaius Asinius Lepidus, Suffect Consul of Rome in 222 and wife (Vettia) (born 190 or 195). Tacitus states that Vipsania was the only one of Agrippa's children