Twenty Twelve Twenty Twelve Twenty Twelve is a BBC television comedy series written and directed by John Morton. Starring Hugh Bonneville, Jessica Hynes and Amelia Bullmore, the programme is a spoof on-location documentary (or mockumentary) following the organisation of the 2012 Summer Olympics in London. It was first broadcast on UK television station BBC Four in March 2011 to coincide with the 500-day countdown to the opening ceremony. "Twenty Twelve" gained mainly positive reviews from critics, and a four-part second series was announced on 15 April 2011, which began airing on 30 March 2012 on BBC Two. A further three episodes of
Lost to follow-up are deceased. Patients who become lost to follow-up during a clinical research trial result in many negative effects on the outcome of the trial and on the pharmaceutical company sponsoring the clinical research trial. Patients who are lost-to-follow-up lead to incomplete study results, which in turn can put a bias on the result of the study as well as a bias on the investigational study medication. A lack of complete results leads to intensified FDA scrutiny of the particular study drug, as well as the pharmaceutical company sponsoring the clinical research study. Biased study outcomes also lead to issues of