Jennifer Jason Leigh becomes a junkie and falls in love with her partner, played by Jason Patric. Her next film, "Single White Female" (1992), was a surprise box-office success, bringing Leigh to her largest mainstream audience yet, portraying a mentally ill woman who terrorizes roommate Bridget Fonda. Leigh was awarded the MTV Movie Award for Best Villain and nominated for Chicago Film Critics Association Award for Best Actress. Leigh co-starred with Kathy Bates as a tormented, pill-popping woman hiding a history of childhood sexual abuse in the adaptation of Stephen King's novel "Dolores Claiborne" (1995). Leigh achieved her greatest acclaim in the role
Jennifer Jason Leigh Chronicle" commented that "As the downtrodden, sexy, trusting and quietly funny prostitute, Leigh is, of course, in her element". Her performance as a manipulative stage mother in Don McKellar's film "Childstar" won her a Genie Award for Best Performance by an Actress in a Supporting Role in 2005. After many years of wanting to be in a Todd Solondz movie, she appeared in "Palindromes" (2004). She also appeared in the psychological thriller "The Jacket" (2005), alongside Adrien Brody. Leigh appeared in the 2008 ensemble film "Synecdoche, New York" and has acted in two films written and directed by her then