BCG vaccine produce BCG. Along with supply availability from existing manufacturers, and a "new WHO prequalified vaccine" the total supply will be "sufficient to meet both suppressed 2015 demand carried over to 2016, as well as total forecast demand through 2016-2018." In the fall of 2011, the Sanofi Pasteur plant flooded causing problems with mold. The facility, located in Toronto, Ontario, Canada, produced BCG vaccine products, made with substrain Connaught, such as a tuberculosis vaccine ImmuCYST, a BCG Immunotherapeutic – a bladder cancer drug. By April 2012 the FDA had found dozens of documented problems with sterility at the plant including mold,
Inoculation theory existed for all hypotheses. The results of their experimentation yielded the understanding that inoculation coupled with reactance-enhanced messages leads to "stronger resistance effects" (p. 148). Consistent with the medical analogy of inoculation theory, Miller, et al. (2013) liken reactance-enhanced messages to a "booster shot," increasing the success of the inoculation. Another unique feature of the study is examining low-controlling language versus high-controlling language and its impact on affect and source credibility. Similarly, Miller, et al. (2007) utilizes psychological reactance theory (Brehm, 1966, 1972; Brehm & Brehm, 1981) to avoid or eliminate source derogation and message rejection. In this study, their