BCG vaccine nesting birds and rusted electrical conduits. The resulting closure of the plant for over two years resulting in shortages of bladder cancer and tuberculosis vaccines. On October 29, 2014 Health Canada gave the permission for Sanofi to resume production of BCG. The global supply situation was analyzed in 2017 and concluded that the global supply is sufficient to meet forecasted BCG vaccine demand but risks for shortages remain mainly due to supply concentration. A weakened strain of bovine tuberculosis bacillus, "Mycobacterium bovis" is specially subcultured in a culture medium, usually Middlebrook 7H9. Some BCG vaccines are freeze dried and become
Inoculation theory existed for all hypotheses. The results of their experimentation yielded the understanding that inoculation coupled with reactance-enhanced messages leads to "stronger resistance effects" (p. 148). Consistent with the medical analogy of inoculation theory, Miller, et al. (2013) liken reactance-enhanced messages to a "booster shot," increasing the success of the inoculation. Another unique feature of the study is examining low-controlling language versus high-controlling language and its impact on affect and source credibility. Similarly, Miller, et al. (2007) utilizes psychological reactance theory (Brehm, 1966, 1972; Brehm & Brehm, 1981) to avoid or eliminate source derogation and message rejection. In this study, their