Isotopes of iodine and non-radioactive materials can be described as "cold." There are instances in which cold iodide is administered to people in order to prevent the uptake of hot iodide by the thyroid gland. For example, blockade of thyroid iodine uptake with potassium iodide is used in nuclear medicine scintigraphy and therapy with some radioiodinated compounds that are not targeted to the thyroid, such as iobenguane (MIBG), which used to image or treat neural tissue tumors, or iodinated fibrinogen, which is used in fibrinogen scans to investigate clotting. These compounds contain iodine, but not in the iodide form. However, since they may
Tincture of iodine Tincture of iodine Tincture of iodine, iodine tincture, or weak iodine solution is an antiseptic. It is usually 2–7% elemental iodine, along with potassium iodide or sodium iodide, dissolved in a mixture of ethanol and water. Tincture solutions are characterized by the presence of alcohol. It was used from 1908 in pre-operative skin preparation by surgeon Antonio Grossich. In the United Kingdom the development of an iodine solution for skin sterilisation was pioneered by Lionel Stretton. The "British Medical Journal" published the detail of his work at Kidderminster Infirmary in 1909. Stretton used a much weaker solution than that used