Hugh Bonneville appeared in the ITV period drama "Downton Abbey", as Robert, Earl of Grantham. In early 2010, he appeared in the comedy film "Burke and Hare". In 2011 and 2012, he starred as Ian Fletcher in the award-winning BBC comedy series "Twenty Twelve", and reprised the role in the 2014 BBC comedy series "W1A". In December 2012, he appeared on BBC Two with co-star Jessica Hynes in "World's Most Dangerous Roads", travelling through Georgia. He also appeared in the much-delayed film "Hippie Hippie Shake" with Cillian Murphy and Sienna Miller. From 2011 until 2014, Bonneville was the narrator of the Channel
Lost to follow-up institutions like the FDA taken action over the recovery of or communication with patients lost-to-follow-up. Section 4.3.4 of the ICH E-6 Good Clinical Practice: Consolidated Guidance reads, "Although a subject is not obliged to give his/her reason(s) for withdrawing prematurely from a trial, the investigator should make a reasonable effort to ascertain the reason(s), while fully respecting the subject's rights." This excerpt expresses the need for physicians associated with clinical research trials to make a first-hand effort to contact patients who are lost-to-follow-up. In doing so pharmaceutical companies not only look out for the best interest of the patients who