BCG vaccine produce BCG. Along with supply availability from existing manufacturers, and a "new WHO prequalified vaccine" the total supply will be "sufficient to meet both suppressed 2015 demand carried over to 2016, as well as total forecast demand through 2016-2018." In the fall of 2011, the Sanofi Pasteur plant flooded causing problems with mold. The facility, located in Toronto, Ontario, Canada, produced BCG vaccine products, made with substrain Connaught, such as a tuberculosis vaccine ImmuCYST, a BCG Immunotherapeutic – a bladder cancer drug. By April 2012 the FDA had found dozens of documented problems with sterility at the plant including mold,
Inoculation Needham states that this information comes from the "Zhongdou xinfa" (種痘心法) written in 1808 by Zhu Yiliang, centuries after the alleged events. The first clear and credible reference to smallpox inoculation in China comes from Wan Quan's (1499–1582) "Douzhen xinfa" (痘疹心法) of 1549, which states that some women unexpectedly menstruate during the procedure, yet his text did not give details on techniques of inoculation. Inoculation was first vividly described by Yu Chang in his book "Yuyi cao" (寓意草), or "Notes on My Judgment", published in 1643. Inoculation was reportedly not widely practised in China until the reign of the Longqing