BCG vaccine produce BCG. Along with supply availability from existing manufacturers, and a "new WHO prequalified vaccine" the total supply will be "sufficient to meet both suppressed 2015 demand carried over to 2016, as well as total forecast demand through 2016-2018." In the fall of 2011, the Sanofi Pasteur plant flooded causing problems with mold. The facility, located in Toronto, Ontario, Canada, produced BCG vaccine products, made with substrain Connaught, such as a tuberculosis vaccine ImmuCYST, a BCG Immunotherapeutic – a bladder cancer drug. By April 2012 the FDA had found dozens of documented problems with sterility at the plant including mold,
Inoculation theory regarding the impact of gender on inoculation effectiveness in issue/advocacy campaigns. The conclusion was made that females are more likely to be inoculated with these types of campaigns. An additional observation made by Burgoon et. al (1995) was that the type of content used in these campaigns contributed to the campaigns success. The further the advertisement was from "direct self-benefit" the greater the inoculation effect was on the audience (Burgoon, et al., 1995). It took quite some time for inoculation theory to be applied to marketing, because of the many limitations (Lessne and Didow, 1987). Lessne and Didow (1987) reviewed