Iodine-125 is preferred for this purpose, due to better radiation penetration and shorter half-life (13 hours). I-125 is useful for Glomerular filtration rate (GFR) testing in the diagnosis or monitoring of patients with kidney disease. I-125 is used in Iodine-125 is used "therapeutically" in brachytherapy treatments of tumors. For radiotherapy ablation of tissues that absorb iodine (such as the thyroid), or that absorb an iodine-containing radiopharmaceutical, the beta-emitter iodine-131 is the preferred isotope. I is created by the electron capture decay of Xe, which is a synthetic isotope of xenon, itself created by neutron capture of the slightly radioactive Xe, which
Iodine demonstrated that these animals could survive after eating a 14000 mg/kg dose). Excess iodine can be more cytotoxic in the presence of selenium deficiency. Iodine supplementation in selenium-deficient populations is, in theory, problematic, partly for this reason. The toxicity derives from its oxidizing properties, through which it denaturates proteins (including enzymes). Elemental iodine is also a skin irritant, and direct contact with skin can cause damage and solid iodine crystals should be handled with care. Solutions with high elemental iodine concentration, such as tincture of iodine and Lugol's solution, are capable of causing tissue damage if used in prolonged cleaning