Congenital iodine deficiency syndrome protruding abdomen. Dwarfism may also be caused by malnutrition or other hormonal deficiencies, such as insufficient growth hormone secretion, hypopituitarism, decreased secretion of growth hormone-releasing hormone, deficient growth hormone receptor activity and downstream causes, such as insulin-like growth factor 1 (IGF-1) deficiency. Sporadic and genetic congenital iodine deficiency syndrome results from abnormal development or growth of the foetal thyroid gland. This type of congenital iodine deficiency has been almost completely eliminated in developed countries by early diagnosis by newborn screening schemes followed by lifelong treatment with thyroxine (T4). Thyroxine must be dosed as tablets only, even to newborns, as the
Tincture of iodine drinking. When an alcohol solution is not desirable for this purpose, the alcohol-free Lugol's iodine, an aqueous solution of iodine in potassium iodide solution, or else povidone-iodine (brand names Wokadine, Betadine), a PVPI solution, can be used. Small amounts may be added to suspect drinking water as a disinfectant (typically 5 mg free iodine per liter, or 5 drops of 2% tincture). Though this treatment is effective against bacteria and virus, it does not protect against protozoan parasites such as "Cryptosporidium" and "Giardia". Iodine solution is used to sanitize the surface of fruit and vegetables for bacteria and virus. The