BCG vaccine of 2004 the vaccine is given to about 100 million children per year globally. The main use of BCG is for vaccination against tuberculosis. BCG vaccine can be administered after birth intradermally. BCG vaccination can cause a false positive Mantoux test, although a very high-grade reading is usually due to active disease. The most controversial aspect of BCG is the variable efficacy found in different clinical trials, which appears to depend on geography. Trials conducted in the UK have consistently shown a protective effect of 60 to 80%, but those conducted elsewhere have shown no protective effect, and efficacy appears
Inoculation the French scientific mission of 1839–1841. The knowledge of inoculating oneself against smallpox seems to have been known to West Africans, more specifically the Akan. A slave named Onesimus explained the inoculation procedure to Cotton Mather during the 18th century; he reported to have gotten the knowledge from Africa. In January 1714 Philosophical Transactions of the Royal Society published an account of a letter John Woodward had received from Emmanuel Timonius in Constantinople. Smallpox inoculation was advocated as a proven method of curbing the severity of the disease. The practice was introduced to England by Lady Mary Wortley Montagu. Lady