Isotopes of iodine and non-radioactive materials can be described as "cold." There are instances in which cold iodide is administered to people in order to prevent the uptake of hot iodide by the thyroid gland. For example, blockade of thyroid iodine uptake with potassium iodide is used in nuclear medicine scintigraphy and therapy with some radioiodinated compounds that are not targeted to the thyroid, such as iobenguane (MIBG), which used to image or treat neural tissue tumors, or iodinated fibrinogen, which is used in fibrinogen scans to investigate clotting. These compounds contain iodine, but not in the iodide form. However, since they may
Iodine the iodyl cation, [IO], and is reduced by concentrated sulfuric acids to iodosyl salts involving [IO]. It may be fluorinated by fluorine, bromine trifluoride, sulfur tetrafluoride, or chloryl fluoride, resulting iodine pentafluoride, which also reacts with iodine pentoxide, giving iodine(V) oxyfluoride, IOF. A few other less stable oxides are known, notably IO and IO; their structures have not been determined, but reasonable guesses are I(IO) and [IO][IO] respectively. More important are the four oxoacids: hypoiodous acid (HIO), iodous acid (HIO), iodic acid (HIO), and periodic acid (HIO or HIO). When iodine dissolves in aqueous solution, the following reactions occur: Hypoiodous