Povidone-iodine is also efficient against fungi and viruses (including HIV and "Herpes simplex"). It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone-iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. There is tentative evidence that chlorhexidine and denatured alcohol used to clean skin prior to surgery is better than povidone-iodine with alcohol; however, the evidence is not strong enough as of 2015 to determine routine practice. PVP-I is contraindicated in patients with hyperthyroidism (overactive thyroid gland) and other diseases of the thyroid,
Isotopes of iodine and 1970s reached about 10). I differs from Cl in that its half-life is longer (15.7 vs. 0.301 million years), it is highly biophilic, and occurs in multiple ionic forms (commonly, I and IO), which have different chemical behaviors. This makes it fairly easy for I to enter the biosphere as it becomes incorporated into vegetation, soil, milk, animal tissue, etc. Of the many isotopes of iodine, only two are typically used in a medical setting: iodine-123 and iodine-131. Since I has both a beta and gamma decay mode, it can be used for radiotherapy or for imaging. I, which