Povidone-iodine is also efficient against fungi and viruses (including HIV and "Herpes simplex"). It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone-iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. There is tentative evidence that chlorhexidine and denatured alcohol used to clean skin prior to surgery is better than povidone-iodine with alcohol; however, the evidence is not strong enough as of 2015 to determine routine practice. PVP-I is contraindicated in patients with hyperthyroidism (overactive thyroid gland) and other diseases of the thyroid,
Iodine with a spectroscopic Doppler-free technique while focusing on one of these lines, the hyperfine structure of the iodine molecule reveals itself. A line is now resolved such that either 15 components, (from even rotational quantum numbers, J), or 21 components (from odd rotational quantum numbers, J) are measurable. Elemental iodine is used as a disinfectant either as the element, or as the water-soluble triiodide anion I generated "in situ" by adding iodide to poorly water-soluble elemental iodine (the reverse chemical reaction makes some free elemental iodine available for antisepsis). Elemental iodine may also be used to treat iodine deficiency. In