BCG vaccine extensively used even in countries where efficacy against pulmonary tuberculosis is negligible. A number of possible reasons for the variable efficacy of BCG in different countries have been proposed. None have been proven, some have been disproved, and none can explain the lack of efficacy in both low-TB burden countries (US) and high-TB burden countries (India). The reasons for variable efficacy have been discussed at length in a WHO document on BCG. BCG has protective effects against some non-tuberculosis mycobacteria. BCG has been one of the most successful immunotherapies. BCG vaccine has been the "standard of care for patients with
Inoculation theory Inoculation in this area improves peoples resistance to such attacks, examples and directions for future work are provided. Recent studies have approached inoculation by incorporating psychological reactance theory (Brehm, 1966, 1972; Brehm & Brehm, 1981) as a means to enhance resistance outcomes through inoculation theory's two key components: threat and refutational preemption. Miller, et al. (2013) focused their study on emerging adults and their reactance to persuasive appeals. Research has demonstrated that this population is in a transitional stage in life (Voyer et al., 2005) and are more likely to defend their behavioral freedoms if they feel others are attempting