BCG vaccine extensively used even in countries where efficacy against pulmonary tuberculosis is negligible. A number of possible reasons for the variable efficacy of BCG in different countries have been proposed. None have been proven, some have been disproved, and none can explain the lack of efficacy in both low-TB burden countries (US) and high-TB burden countries (India). The reasons for variable efficacy have been discussed at length in a WHO document on BCG. BCG has protective effects against some non-tuberculosis mycobacteria. BCG has been one of the most successful immunotherapies. BCG vaccine has been the "standard of care for patients with
Inoculation theory counterarguments, the inoculation receiver will then seek out supporting information to further strengthen their threatened position. Finally, the held attitude or belief becomes resistant to a stronger attack, hence the medical analogy of a vaccine. Inoculation is a theory developed to strengthen existing attitudes and beliefs while building resistance to future counterarguments. For inoculation to be successful it is crucial that a threat (motivation for resistance) is imposed upon these existing ideas and refutational preemption (ability to build defenses against potential counterarguments) takes place after the inoculation. The argument that is presented through inoculation must be strong enough to initiate