Lao kip De La Rue. A 1975 10 kip by Bradbury & Wilkinson and a 1000 kip by De la Rue were printed but not circulated. The Pathet Lao kip was introduced sometime before 1976 in the areas which were under the control of the Pathet Lao. Banknote denominations of 1, 10, 20, 50, 100, 200 and 500 kip were issued. The notes were printed in China. In 1976, the Pathet Lao kip replaced the Royal kip throughout Laos following the Pathet Lao's take over of the country. The exchange rate between the two kip was 1 Pathet Lao kip = 20
CIP/KIP of the E2F transcription factor. CIP/KIP proteins have also been shown to directly bind transcription factors. For example. p27 has been shown to bind to and stabilize Neurogenin-2 promoting differentiation of neural progenitor cells. CIP/KIP proteins have previously been shown to inhibit Rho/ROCK/LIMK/Cofilin signaling. In addition, fibroblasts deficient for p27 have reduced motility. p27 deficient fibroblasts also have increased levels of stress fibers and focal adhesions. The role of CIP/KIP proteins in motility has also become particularly of interest in cancer where misregulation of p27 could result in increased proliferation and increased motility which may contribute to more invasive cancers.