Iodine-125 is preferred for this purpose, due to better radiation penetration and shorter half-life (13 hours). I-125 is useful for Glomerular filtration rate (GFR) testing in the diagnosis or monitoring of patients with kidney disease. I-125 is used in Iodine-125 is used "therapeutically" in brachytherapy treatments of tumors. For radiotherapy ablation of tissues that absorb iodine (such as the thyroid), or that absorb an iodine-containing radiopharmaceutical, the beta-emitter iodine-131 is the preferred isotope. I is created by the electron capture decay of Xe, which is a synthetic isotope of xenon, itself created by neutron capture of the slightly radioactive Xe, which
Iodine be obtained pure. It can be synthesised from the reaction of iodine with fluorine gas in trichlorofluoromethane at −45 °C, with iodine trifluoride in trichlorofluoromethane at −78 °C, or with silver(I) fluoride at 0 °C. Iodine monochloride (ICl) and iodine monobromide (IBr), on the other hand, are moderately stable. The former, a volatile red-brown compound, was discovered independently by Joseph Louis Gay-Lussac and Humphry Davy in 1813–4 not long after the discoveries of chlorine and iodine, and it mimics the intermediate halogen bromine so well that Justus von Liebig was misled into mistaking bromine (which he had found) for iodine