Isotopes of iodine and non-radioactive materials can be described as "cold." There are instances in which cold iodide is administered to people in order to prevent the uptake of hot iodide by the thyroid gland. For example, blockade of thyroid iodine uptake with potassium iodide is used in nuclear medicine scintigraphy and therapy with some radioiodinated compounds that are not targeted to the thyroid, such as iobenguane (MIBG), which used to image or treat neural tissue tumors, or iodinated fibrinogen, which is used in fibrinogen scans to investigate clotting. These compounds contain iodine, but not in the iodide form. However, since they may
Iodine monofluoride −45 °C in CClF: It can also be generated by the reaction of iodine with iodine trifluoride at −78 °C in CClF: The reaction of iodine with silver(I) fluoride at 0 °C also yields iodine monofluoride: Iodine monofluoride is used to produce pure nitrogen triiodide: Iodine monofluoride Iodine monofluoride is an interhalogen compound of iodine and fluorine with formula IF. It is a chocolate-brown solid that decomposes at 0 C, disproportionating to elemental iodine and iodine pentafluoride: However, its molecular properties can still be precisely determined by spectroscopy: the iodine-fluorine distance is 190.9 pm and the I−F bond dissociation energy