BCG vaccine and one disaster, in particular, did much to harm public acceptance of the vaccine. In the summer of 1930 in Lübeck, 240 infants were vaccinated in the first 10 days of life; almost all developed tuberculosis and 72 infants died. It was subsequently discovered that the BCG administered there had been contaminated with a virulent strain that was being stored in the same incubator, which led to legal action against the manufacturers of the vaccine. Dr. R.G. Ferguson, working at the Fort Qu'Appelle Sanatorium in Saskatchewan, was among the pioneers in developing the practice of vaccination against tuberculosis. In 1928,
Inoculation is derived from the Latin "in + oculus" (eye). Though "innoculation/innoculate" (with a double "nn" rather than a single "n") is sometimes seen, this is incorrect, possibly erroneously thought to be related to innocuous, which is derived from the Latin "in + nocuus" (not harmful). Inoculation originated as a method for the prevention of smallpox by deliberate introduction of material from smallpox pustules into the skin. This generally produced a less severe infection than naturally-acquired smallpox, but still induced immunity to it. This first method for smallpox prevention, smallpox inoculation, is now also known as variolation. Inoculation has ancient origins