Iodine-125 is preferred for this purpose, due to better radiation penetration and shorter half-life (13 hours). I-125 is useful for Glomerular filtration rate (GFR) testing in the diagnosis or monitoring of patients with kidney disease. I-125 is used in Iodine-125 is used "therapeutically" in brachytherapy treatments of tumors. For radiotherapy ablation of tissues that absorb iodine (such as the thyroid), or that absorb an iodine-containing radiopharmaceutical, the beta-emitter iodine-131 is the preferred isotope. I is created by the electron capture decay of Xe, which is a synthetic isotope of xenon, itself created by neutron capture of the slightly radioactive Xe, which
Iodine be primordial. As such, iodine is monoisotopic and its atomic weight is known to great precision, as it is a constant of nature. The longest-lived of the radioactive isotopes of iodine is iodine-129, which has a half-life of 15.7 million years, decaying via beta decay to stable xenon-129. Some iodine-129 was formed along with iodine-127 before the formation of the Solar System, but it has by now completely decayed away, making it an extinct radionuclide that is nevertheless still useful in dating the history of the early Solar System or very old groundwaters, due to its mobility in the environment.