Congenital iodine deficiency syndrome protruding abdomen. Dwarfism may also be caused by malnutrition or other hormonal deficiencies, such as insufficient growth hormone secretion, hypopituitarism, decreased secretion of growth hormone-releasing hormone, deficient growth hormone receptor activity and downstream causes, such as insulin-like growth factor 1 (IGF-1) deficiency. Sporadic and genetic congenital iodine deficiency syndrome results from abnormal development or growth of the foetal thyroid gland. This type of congenital iodine deficiency has been almost completely eliminated in developed countries by early diagnosis by newborn screening schemes followed by lifelong treatment with thyroxine (T4). Thyroxine must be dosed as tablets only, even to newborns, as the
Iodine-125 Iodine-125 Iodine-125 (I) is a radioisotope of iodine which has uses in biological assays, nuclear medicine imaging and in radiation therapy as brachytherapy to treat a number of conditions, including prostate cancer, uveal melanomas, and brain tumors. It is the second longest-lived radioisotope of iodine, after iodine-129. Its half-life is 59.49 days and it decays by electron capture to an excited state of tellurium-125. This state is not the metastable Te-125m, but rather a lower energy state that decays immediately by gamma decay with a maximum energy of 35 keV. Some of the excess energy of the excited Te-125 may