BCG vaccine fine powder. Sometimes the powder is sealed with vacuum in a glass ampoule. Such a glass ampoule has to be opened slowly to prevent the airflow from blowing out the powder. Then the powder has to be diluted with saline water before injecting. The history of BCG is tied to that of smallpox. Jean Antoine Villemin first recognized bovine tuberculosis in 1854 and transmitted it, and Robert Koch first distinguished "Mycobacterium bovis" from "Mycobacterium tuberculosis". Following the success of vaccination in preventing smallpox, established during the 18th century, scientists thought to find a corollary in tuberculosis by drawing a parallel
Inoculation theory to initially describe his theory. Unsurprisingly, inoculation strategies can be most effective when combined with health issues. Inoculation theory research, as applied to advertising and marketing, are primarily focused on promoting healthy lifestyles with the help of a product or for a specific company's goal. Shortly after McGuire published his development on inoculation theory, Szybillo and Heslin (1973) applied the concepts that McGuire used in the health industry to advertising and marketing campaigns. They sought to provide answers for advertisers marketing a controversial product or topic: if an advertiser knew the product or campaign would cause an attack, what would