Lugol's iodine a source of effectively free elemental iodine, which is readily generated from the equilibrium between elemental iodine molecules and polyiodide ions in the solution. It was historically used as a first line treatment for hyperthyroidism, as the administration of pharmacologic amounts of iodine leads to temporary inhibition of iodine organification in the thyroid gland, a phenomenon called the Wolff-Chaikoff effect. However it is not used to treat certain autoimmune causes of thyroid disease as iodine-induced blockade of iodine organification may result in hypothyroidism. They are not considered as a first line therapy because of possible induction of resistant hyperthyroidism but
Iodine monofluoride −45 °C in CClF: It can also be generated by the reaction of iodine with iodine trifluoride at −78 °C in CClF: The reaction of iodine with silver(I) fluoride at 0 °C also yields iodine monofluoride: Iodine monofluoride is used to produce pure nitrogen triiodide: Iodine monofluoride Iodine monofluoride is an interhalogen compound of iodine and fluorine with formula IF. It is a chocolate-brown solid that decomposes at 0 C, disproportionating to elemental iodine and iodine pentafluoride: However, its molecular properties can still be precisely determined by spectroscopy: the iodine-fluorine distance is 190.9 pm and the I−F bond dissociation energy