BCG vaccine extensively used even in countries where efficacy against pulmonary tuberculosis is negligible. A number of possible reasons for the variable efficacy of BCG in different countries have been proposed. None have been proven, some have been disproved, and none can explain the lack of efficacy in both low-TB burden countries (US) and high-TB burden countries (India). The reasons for variable efficacy have been discussed at length in a WHO document on BCG. BCG has protective effects against some non-tuberculosis mycobacteria. BCG has been one of the most successful immunotherapies. BCG vaccine has been the "standard of care for patients with
A2261-BCG A2261-BCG A2261-BCG (short for Abell 2261 Brightest Cluster Galaxy) is a huge elliptical galaxy in the cluster Abell 2261. One of the largest galaxies known, A2261-BCG is estimated to have a diameter of a million light-years, some 10 times larger than the Milky Way. It is the brightest and the most massive galaxy in the cluster, and has the largest galactic core ever observed, spanning more than 10,000 light-years. The cD elliptical galaxy, located at least 3 billion light-years from Earth, is also well known as a radio source. Its core is highly populated by a dense number of old