BCG vaccine nesting birds and rusted electrical conduits. The resulting closure of the plant for over two years resulting in shortages of bladder cancer and tuberculosis vaccines. On October 29, 2014 Health Canada gave the permission for Sanofi to resume production of BCG. The global supply situation was analyzed in 2017 and concluded that the global supply is sufficient to meet forecasted BCG vaccine demand but risks for shortages remain mainly due to supply concentration. A weakened strain of bovine tuberculosis bacillus, "Mycobacterium bovis" is specially subcultured in a culture medium, usually Middlebrook 7H9. Some BCG vaccines are freeze dried and become
Inoculation theory are more likely to be inoculated by issue/advocacy messages. They use Mobil Oil's issue/advocacy campaign to test the hypotheses. The first hypothesis was supported by the data. There was a significant effect provided by inoculation. Additionally, H1 showed that issue/advocacy inoculation messages and attack messages vary in effectiveness depending on the content. The result was also noted in the results of H2, which were also supported by the results. Finally, the results indicated that political views play a role in the effectiveness of the campaigns. Thus, confirming H3, that conservatives are easier to inoculate. They also posed a research question