Hugh Bonneville appeared in the ITV period drama "Downton Abbey", as Robert, Earl of Grantham. In early 2010, he appeared in the comedy film "Burke and Hare". In 2011 and 2012, he starred as Ian Fletcher in the award-winning BBC comedy series "Twenty Twelve", and reprised the role in the 2014 BBC comedy series "W1A". In December 2012, he appeared on BBC Two with co-star Jessica Hynes in "World's Most Dangerous Roads", travelling through Georgia. He also appeared in the much-delayed film "Hippie Hippie Shake" with Cillian Murphy and Sienna Miller. From 2011 until 2014, Bonneville was the narrator of the Channel
Lost to follow-up Lost to follow-up In the clinical research trial industry, lost to follow-up refers to patients who at one point in time were actively participating in a clinical research trial, but have become lost (either by error in a computer tracking system or by being unreachable) at the point of follow-up in the trial. These patients can become lost for many reasons. Without properly informing the investigator associated with the clinical trial, they may have opted to withdraw from the clinical trial, moved away from the particular study site during the clinical trial, or become ill and unable to communicate or