BCG vaccine fine powder. Sometimes the powder is sealed with vacuum in a glass ampoule. Such a glass ampoule has to be opened slowly to prevent the airflow from blowing out the powder. Then the powder has to be diluted with saline water before injecting. The history of BCG is tied to that of smallpox. Jean Antoine Villemin first recognized bovine tuberculosis in 1854 and transmitted it, and Robert Koch first distinguished "Mycobacterium bovis" from "Mycobacterium tuberculosis". Following the success of vaccination in preventing smallpox, established during the 18th century, scientists thought to find a corollary in tuberculosis by drawing a parallel
Inoculation theory existed for all hypotheses. The results of their experimentation yielded the understanding that inoculation coupled with reactance-enhanced messages leads to "stronger resistance effects" (p. 148). Consistent with the medical analogy of inoculation theory, Miller, et al. (2013) liken reactance-enhanced messages to a "booster shot," increasing the success of the inoculation. Another unique feature of the study is examining low-controlling language versus high-controlling language and its impact on affect and source credibility. Similarly, Miller, et al. (2007) utilizes psychological reactance theory (Brehm, 1966, 1972; Brehm & Brehm, 1981) to avoid or eliminate source derogation and message rejection. In this study, their