Hugh Bonneville appeared in the ITV period drama "Downton Abbey", as Robert, Earl of Grantham. In early 2010, he appeared in the comedy film "Burke and Hare". In 2011 and 2012, he starred as Ian Fletcher in the award-winning BBC comedy series "Twenty Twelve", and reprised the role in the 2014 BBC comedy series "W1A". In December 2012, he appeared on BBC Two with co-star Jessica Hynes in "World's Most Dangerous Roads", travelling through Georgia. He also appeared in the much-delayed film "Hippie Hippie Shake" with Cillian Murphy and Sienna Miller. From 2011 until 2014, Bonneville was the narrator of the Channel
Lost to follow-up are deceased. Patients who become lost to follow-up during a clinical research trial result in many negative effects on the outcome of the trial and on the pharmaceutical company sponsoring the clinical research trial. Patients who are lost-to-follow-up lead to incomplete study results, which in turn can put a bias on the result of the study as well as a bias on the investigational study medication. A lack of complete results leads to intensified FDA scrutiny of the particular study drug, as well as the pharmaceutical company sponsoring the clinical research study. Biased study outcomes also lead to issues of