Iodine in biology damage). In areas where there is little iodine in the diet, typically remote inland areas and semi-arid equatorial climates where no marine foods are eaten, iodine deficiency also gives rise to hypothyroidism, the most serious symptoms of which are epidemic goitre (swelling of the thyroid gland), extreme fatigue, mental slowing, depression, weight gain, and low basal body temperatures. The addition of iodine to table salt (so-called iodized salt) has largely eliminated the most severe consequences of iodine deficiency in wealthier nations, but deficiency remains a serious public health problem in the developing world. Iodine deficiency is also a problem in
Pineal gland retina of the lateral eyes of vertebrates. In most vertebrates, exposure to light sets off a chain reaction of enzymatic events within the pineal gland that regulates circadian rhythms. In humans and other mammals, the light signals necessary to set circadian rhythms are sent from the eye through the retinohypothalamic system to the suprachiasmatic nuclei (SCN) and the pineal gland. The fossilized skulls of many extinct vertebrates have a pineal foramen (opening), which in some cases is larger than that of any living vertebrate. Although fossils seldom preserve deep-brain soft anatomy, the brain of the Russian fossil bird "Cerebavis cenomanica"