Lugol's iodine a source of effectively free elemental iodine, which is readily generated from the equilibrium between elemental iodine molecules and polyiodide ions in the solution. It was historically used as a first line treatment for hyperthyroidism, as the administration of pharmacologic amounts of iodine leads to temporary inhibition of iodine organification in the thyroid gland, a phenomenon called the Wolff-Chaikoff effect. However it is not used to treat certain autoimmune causes of thyroid disease as iodine-induced blockade of iodine organification may result in hypothyroidism. They are not considered as a first line therapy because of possible induction of resistant hyperthyroidism but
Lugol's iodine 126.5 mg/mL. The 15% solution thus has a total iodine content of 6.32 mg per drop of 0.05 mL; the 2% solution has 0.84 mg total iodine content per drop. Potassium iodide renders the elementary iodine soluble in water through the formation of the triiodide () ion. It is not to be confused with tincture of iodine solutions, which consist of elemental iodine, and iodide salts dissolved in water and alcohol. Lugol's solution contains no alcohol. Other names for Lugol's solution are (iodine-potassium iodide); Markodine, Strong solution (Systemic); and Aqueous Iodine Solution BP. In the United Kingdom the NHS pays