A Shot in the Dark (1964 film) him to take over as director of "A Shot in the Dark" from Anatole Litvak. Edwards declined initially, but eventually relented under pressure on the condition he could rewrite the script and substitute Inspector Clouseau for the lead character and choreograph comic scenes on the fly as he and Sellers had successfully done for their previous film. The relationship between Edwards and Sellers deteriorated to such a point that at the conclusion of the film they vowed never to work together again. They eventually reconciled to collaborate successfully four years later on "The Party", and on three more "Pink Panther"
Lost to follow-up are deceased. Patients who become lost to follow-up during a clinical research trial result in many negative effects on the outcome of the trial and on the pharmaceutical company sponsoring the clinical research trial. Patients who are lost-to-follow-up lead to incomplete study results, which in turn can put a bias on the result of the study as well as a bias on the investigational study medication. A lack of complete results leads to intensified FDA scrutiny of the particular study drug, as well as the pharmaceutical company sponsoring the clinical research study. Biased study outcomes also lead to issues of