Povidone-iodine is also efficient against fungi and viruses (including HIV and "Herpes simplex"). It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone-iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. There is tentative evidence that chlorhexidine and denatured alcohol used to clean skin prior to surgery is better than povidone-iodine with alcohol; however, the evidence is not strong enough as of 2015 to determine routine practice. PVP-I is contraindicated in patients with hyperthyroidism (overactive thyroid gland) and other diseases of the thyroid,
Iodine monofluoride −45 °C in CClF: It can also be generated by the reaction of iodine with iodine trifluoride at −78 °C in CClF: The reaction of iodine with silver(I) fluoride at 0 °C also yields iodine monofluoride: Iodine monofluoride is used to produce pure nitrogen triiodide: Iodine monofluoride Iodine monofluoride is an interhalogen compound of iodine and fluorine with formula IF. It is a chocolate-brown solid that decomposes at 0 C, disproportionating to elemental iodine and iodine pentafluoride: However, its molecular properties can still be precisely determined by spectroscopy: the iodine-fluorine distance is 190.9 pm and the I−F bond dissociation energy