BCG vaccine fine powder. Sometimes the powder is sealed with vacuum in a glass ampoule. Such a glass ampoule has to be opened slowly to prevent the airflow from blowing out the powder. Then the powder has to be diluted with saline water before injecting. The history of BCG is tied to that of smallpox. Jean Antoine Villemin first recognized bovine tuberculosis in 1854 and transmitted it, and Robert Koch first distinguished "Mycobacterium bovis" from "Mycobacterium tuberculosis". Following the success of vaccination in preventing smallpox, established during the 18th century, scientists thought to find a corollary in tuberculosis by drawing a parallel
Inoculation theory Inoculation in this area improves peoples resistance to such attacks, examples and directions for future work are provided. Recent studies have approached inoculation by incorporating psychological reactance theory (Brehm, 1966, 1972; Brehm & Brehm, 1981) as a means to enhance resistance outcomes through inoculation theory's two key components: threat and refutational preemption. Miller, et al. (2013) focused their study on emerging adults and their reactance to persuasive appeals. Research has demonstrated that this population is in a transitional stage in life (Voyer et al., 2005) and are more likely to defend their behavioral freedoms if they feel others are attempting