Thyroid appearance of cells is viewed to determine whether they resemble normal or cancerous cells. There can be many nodules, which is termed a multinodular goitre, and this can sometimes be a toxic multinodular goitre. An enlarged thyroid gland is called a goitre. Goitres are present in some form in about 5% of people, and are the result of a large number of causes, including iodine deficiency, autoimmune disease (both Grave's disease and Hashimoto's thyroiditis), infection, inflammation, and infltrative disease such as sarcoidosis and amyloidosis. Sometimes no cause can be found, a state called "simple goitre". Some forms of goitre are
Aromatase deficiency the low oestrogen will predispose those with the condition to osteoporosis. Symptoms are generally manifested in adulthood: During gestation, a baby with Aromatase Deficiency can cause a mother to become virilised by causing the deepening of the voice, cystic acne, cliteromegaly, and hirsutism. The mother also has an increased level of circulating testosterone. However, the symptoms normally regress post-partum. Aromatase deficiency is an autosomal recessive disease with most of the mutations occur along the highly conservative regions of the gene. Both homozygous and heterozygous mutations have been identified along various location of the exon on the P450 arom (CYP19) gene