Elbrus-2S+ Elbrus-2S+ Elbrus-2S+ () is a multi-core microprocessor based on the Elbrus 2000 architecture developed by Moscow Center of SPARC Technologies (MCST) There are multiple reports regarding the evolution of this technology for the purpose of import substitution in Russia, which was raised by several ministries on July 2014, due to economic sanctions in response to 2014 pro-Russian unrest in Ukraine. In December 2014, it was announced that Mikron start pilot production of a dual-core variant of this microprocessor called Elbrus-2SM () using a 90 nanometer CMOS manufacturing process in Zelenograd, Russia. The Elbrus-4S CPU is reported to have built in
MT-ND4L are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH). The flow of electrons changes the redox state of the protein, resulting in a conformational change and p"K" shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. Mitochondrial dysfunction resulting from variants of MT-ND4L, MT-ND1 and MT-ND2 have been linked to BMI in adults and implicated in metabolic disorders including obesity, diabetes and hypertension. A T>C mutation at position 10,663 in the mitochondrial gene MT-ND4L is known to