Mount Elbrus 100 people to be attempting the summit via this route each day. Winter ascents are rare, and are usually undertaken only by very experienced climbers. Elbrus is notorious for its brutal winter weather, and summit attempts are few and far between. The climb is not technically difficult, but it is physically arduous because of the elevations and the frequent strong winds. The average annual death toll on Elbrus is 15–30, primarily due to "many unorganized and poorly equipped" attempts to summit the mountain. Since 1986, Elbrus has been incorporated into Prielbrusye National Park, one of the Protected areas of Russia.
MT-ND4L are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH). The flow of electrons changes the redox state of the protein, resulting in a conformational change and p"K" shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. Mitochondrial dysfunction resulting from variants of MT-ND4L, MT-ND1 and MT-ND2 have been linked to BMI in adults and implicated in metabolic disorders including obesity, diabetes and hypertension. A T>C mutation at position 10,663 in the mitochondrial gene MT-ND4L is known to