Uranium ore for silver in the 16th century. F.E. Brückmann made the first mineralogical description of the mineral in 1727 and the vein deposit Jachymov in the Czech Republic became the type locality for uraninite. In 1789 the German chemist M. H. Klaproth discovered the element of uranium in a sample of pitchblende from the Johanngeorgenstadt vein deposit. The first industrial production of uranium was made from the Jachymov deposit and Marie and Pierre Curie used the tailings of the mine for their discovery of polonium and radium. Vein deposits consist of uranium minerals filling in cavities such as cracks, veins, fractures,
Uranium weakly radioactive, uranium is a toxic metal. Uranium is also a reproductive toxicant. Radiological effects are generally local because alpha radiation, the primary form of U decay, has a very short range, and will not penetrate skin. Alpha radiation from inhaled uranium has been demonstrated to cause lung cancer in exposed nuclear workers. Uranyl () ions, such as from uranium trioxide or uranyl nitrate and other hexavalent uranium compounds, have been shown to cause birth defects and immune system damage in laboratory animals. While the CDC has published one study that no human cancer has been seen as a result