Goitre a choker, dubbed "Kropfband" (struma band) which was used to hide either the goitre or the remnants of goitre surgery. In the 1920s wearing bottles of iodine around the neck was believed to prevent goitre. The coat of arms and crest of Die Kröpfner, of Tyrol showed a man "afflicted with a large goitre", an apparent pun on the German for the word ("Kropf"). Goitre A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre is associated with a thyroid that is not functioning properly. Worldwide, over 90% of goitre cases are
Cernunnos deficiency Cernunnos deficiency Cernunnos deficiency is a form of combined immunodeficiency characterized by microcephaly, due to mutations in the NHEJ1 gene, it is inherited via autosomal recessive manner Management for this condition is antiviral prophylaxis and antibiotic treatment The sign and symptoms of this condition on an affected individual are as follows: In terms of genetics the condition, Cernunnos deficiency is due to a mutation in the NHEJ1 gene, it has a cytogenetic location of 2q35, while its molecular location is 219,075,324 to 219,160,865 The pathophysiology of Cernunnos deficiency begins with normal function of "Non-homologous end-joining factor 1" gene. NHEJ1 encodes