Goitre related to hypermetabolism, (increased metabolism), excessive thyroid hormone, an increase in oxygen consumption, metabolic changes in protein metabolism, immunologic stimulation of diffuse goitre, and ocular changes (exophthalmos). Hypothyroid individuals may have weight gain despite poor appetite, cold intolerance, constipation and lethargy. However, these symptoms are often non-specific and make diagnosis difficult. A goitre may be classified either as nodular or diffuse. Nodular goitres are either of one nodule (uninodular) or of multiple nodules (multinodular). Worldwide, the most common cause for goitre is iodine deficiency, usually seen in countries that do not use iodized salt. Selenium deficiency is also considered a
ZC4H2 deficiency neurological manifestations. These can include: To date, there is no cure or effective treatment for this condition. Current approach is limited to supportive therapies and interventions. ZC4H2 deficiency ZC4H2 (Zinc finger C4H2-type) is a protein-coding gene located on the X-chromosome. This gene encodes a protein which is a member of the so-called zinc finger domain-containing protein family. There is currently very limited understanding about the ZC4H2 gene and its protein function. Any pathogenic variant of ZC4H2 which is associated with a clinical phenotype is referred to as "ZC4H2 Deficiency". The limited research published to date indicates that ZC4H2 is expressed