Toxic multinodular goitre Toxic multinodular goitre Toxic multinodular goiter (also known as toxic nodular goiter, or Plummer's disease) is an active multinodular goiter associated with hyperthyroidism. It is a common cause of hyperthyroidism in which there is excess production of thyroid hormones from functionally autonomous thyroid nodules, which do not require stimulation from thyroid stimulating hormone (TSH). Toxic multinodular goiter is the second most common cause of hyperthyroidism (after Graves' disease) in the developed world, whereas iodine deficiency is the most common cause of hypothyroidism in developing-world countries where the population is iodine-deficient. (Decreased iodine leads to decreased thyroid hormone.) However, iodine deficiency
Without a Trace (film) confusion with the 1982 film "Missing". The film was released in North America on February 4, 1983, and grossed $9.6 million. Janet Maslin of "The New York Times" called it "a reasonably well-made film" on its own terms but said it "deserves more thoughtful and imaginative treatment". Without a Trace (film) Without a Trace is a 1983 American drama film. It is based on the novel "Still Missing" by Beth Gutcheon. The film stars Kate Nelligan, Judd Hirsch, David Dukes and Stockard Channing. The story is partly based on the disappearance of Etan Patz. Susan Selky is a well-known English