House of Braganza great difficulty under the reign of King João II. By the tenure of the third duke, Fernando II, the House of Braganza was undoubtedly one of the greatest noble houses of Portugal and Iberia as a whole. Fernando II continued the House's legacy of acquisition and gained the title of Duke of Guimarães. To the Duke and the House's downfall, however, King João II's reign concerned itself with the royal consolidation of power and the diminishment of the nobility. In his mission to centralize power, the King executed many nobleman of the great houses of Portugal, alongside confiscating their properties
Teodósio I, Duke of Braganza of Braganza. In 1559, he remarried with Beatriz of Lencastre (1542–1623), granddaughter of Infante George of Lencastre, Duke of Coimbra. Their first child, Jaime of Braganza, died without issue in 1578, in the Battle of Alcacer Quibir. Their second child, Isabel, married the 1st Duke of Caminha. Teodósio I, Duke of Braganza Dom Teodósio I of Braganza (; 1510 – 22 September 1563) was the 5th Duke of Braganza, among other titles. He is known for ceding the title of Duke of Guimarães to Infante Duarte of Aviz, alongside some of the wealth and properties of the House of Braganza.