Endemic goitre Endemic goitre Endemic goiter is a type of goitre that is associated with dietary iodine deficiency. Some inland areas where soil and water lacks in iodine compounds and consumption of marine foods is low are known for higher incidence of goitre. In such areas goitre is said to be "endemic". This type of goiter is easily preventable. In most developed countries regulations have been put into force by health policy institutions requiring salt, flour or water to be fortified with iodine. Treatment of endemic goiter is medical with iodine and thyroxine preparations. Surgery is only necessary in cases where complicated
Selective immunoglobulin A deficiency risk of developing autoimmune diseases in middle age. IgA deficiency and common variable immunodeficiency (CVID) feature similar B cell differentiation arrests, it does not present the same lymphocyte subpopulation abnormalities. IgA-deficient patients may progress to panhypogammaglobulinemia characteristic of CVID. Selective IgA and CVID are found in the same family. Selective IgA deficiency is inherited and has been associated with differences in chromosomes 18, 14 and 6. Selective IgA deficiency is often inherited, but has been associated with some congenital intrauterine infections. Pathogenesis of IgA Deficiency ‘In IgA-deficient patients, the common finding is a maturation defect in B cells to produce