Goitre related to hypermetabolism, (increased metabolism), excessive thyroid hormone, an increase in oxygen consumption, metabolic changes in protein metabolism, immunologic stimulation of diffuse goitre, and ocular changes (exophthalmos). Hypothyroid individuals may have weight gain despite poor appetite, cold intolerance, constipation and lethargy. However, these symptoms are often non-specific and make diagnosis difficult. A goitre may be classified either as nodular or diffuse. Nodular goitres are either of one nodule (uninodular) or of multiple nodules (multinodular). Worldwide, the most common cause for goitre is iodine deficiency, usually seen in countries that do not use iodized salt. Selenium deficiency is also considered a
Without a Trace (film) confusion with the 1982 film "Missing". The film was released in North America on February 4, 1983, and grossed $9.6 million. Janet Maslin of "The New York Times" called it "a reasonably well-made film" on its own terms but said it "deserves more thoughtful and imaginative treatment". Without a Trace (film) Without a Trace is a 1983 American drama film. It is based on the novel "Still Missing" by Beth Gutcheon. The film stars Kate Nelligan, Judd Hirsch, David Dukes and Stockard Channing. The story is partly based on the disappearance of Etan Patz. Susan Selky is a well-known English