Toxic multinodular goitre Toxic multinodular goitre Toxic multinodular goiter (also known as toxic nodular goiter, or Plummer's disease) is an active multinodular goiter associated with hyperthyroidism. It is a common cause of hyperthyroidism in which there is excess production of thyroid hormones from functionally autonomous thyroid nodules, which do not require stimulation from thyroid stimulating hormone (TSH). Toxic multinodular goiter is the second most common cause of hyperthyroidism (after Graves' disease) in the developed world, whereas iodine deficiency is the most common cause of hypothyroidism in developing-world countries where the population is iodine-deficient. (Decreased iodine leads to decreased thyroid hormone.) However, iodine deficiency
The Trace (Land Between the Lakes) The Trace (Land Between the Lakes) The Woodlands Trace National Scenic Byway, also known as "The Trace," is the major north–south roadway that traverses the Land Between the Lakes National Recreation Area in two counties in western Kentucky and northwestern Stewart County in northwest Middle Tennessee. It is estimated to be in length. The road is part of the National Scenic Byway system. Although it is not signed, it is listed on LBL's road logs as FD-100. The road is called "The Trace", which is what many roads and paths were called in pioneer times. "Trace" is short for "Buffalo