Afonso I, Duke of Braganza time, to his first cousin once removed, Constance of Noronha, daughter of Alfonso Enríquez, Count of Gijón and Noreña (a natural son of Henry II of Castile), and of Isabel of Portugal (a natural daughter of Fernando I of Portugal). They had no issue. Afonso I, Duke of Braganza Dom Afonso I of Braganza (; 10 August 1377 – 15 December 1461) was the first Duke of Braganza and the eighth Count of Barcelos. He would start a dynasty, the House of Braganza, that would end up being the most powerful and wealthy in all of Portugal. His descendants would
House of Braganza of Marquis of Vila Viçosa and Count of Neiva. Fernando I's children, by his wife, Joana de Castro, Lady of Cadaval, continued to enlarge the influence of the House of Braganza. Of his nine children, all six who survived to adulthood established themselves either through positions or marriages, though the actions of King João II would seek to weaken their influence. Fernando I's first son and successor, Fernando II, was initially a bright and popular nobleman, but his conflict with King João II would see his and the House's downfall. His second son, João of Braganza, 1st Marquis of Montemor-o-Novo,