Toxic multinodular goitre Toxic multinodular goitre Toxic multinodular goiter (also known as toxic nodular goiter, or Plummer's disease) is an active multinodular goiter associated with hyperthyroidism. It is a common cause of hyperthyroidism in which there is excess production of thyroid hormones from functionally autonomous thyroid nodules, which do not require stimulation from thyroid stimulating hormone (TSH). Toxic multinodular goiter is the second most common cause of hyperthyroidism (after Graves' disease) in the developed world, whereas iodine deficiency is the most common cause of hypothyroidism in developing-world countries where the population is iodine-deficient. (Decreased iodine leads to decreased thyroid hormone.) However, iodine deficiency
Leave a Trace her feelings and finding closure, and delivering a sweet vocal that drills deep into the pleasure centres." Abby Johnston of "The Austin Chronicle" called Mayberry's performance in the song "at the level of a modern-day Cyndi Lauper." "Rolling Stone" placed "Leave a Trace" at number 24 on its list of the 50 Best Songs of 2015. "Billboard" ranked "Leave a Trace" at number fourteen on its year-end list: "On 'Leave a Trace', Iain Cook and Martin Doherty’s fine-tuned swirls of synthesizer are just begging for a killer hook, and Mayberry -- singing with more swagger than ever before -- hammers