Iodine deficiency in China goitre. This disease causes a swelling in the neck, where the thyroid glands are, leading to impaired cognitive abilities. The child population was about 20% saturated with the disease but continues to decrease with the new initiatives. Another common IDD prevalent in China is Kashin-Beck disease. A particular outbreak in Tibet was recorded as occurring from lack of iodine. Kashin-Beck is a bone deformity endemic. Iodine deficiency, hypothyroidism, and low serum concentrations of thyroxine-binding globulin were significantly related to Kashin–Beck disease. Iodine supplemented irrigation water in combination to iodized salt helps in reducing the neonatal and infant mortality rates. The
Glutathione synthetase deficiency Glutathione synthetase deficiency Glutathione synthetase deficiency is a rare autosomal recessive metabolic disorder that prevents the production of glutathione. Glutathione helps prevent damage to cells by neutralizing harmful molecules generated during energy production. Glutathione also plays a role in processing medications and cancer-causing compounds (carcinogens), and building DNA, proteins, and other important cellular components. Mutations in the "GSS" gene cause glutathione synthetase deficiency. This gene provides instructions for making the enzyme glutathione synthetase. This enzyme is involved in a process called the gamma-glutamyl cycle, which takes place in most of the body's cells. This cycle is necessary for producing a