Toxic multinodular goitre Toxic multinodular goitre Toxic multinodular goiter (also known as toxic nodular goiter, or Plummer's disease) is an active multinodular goiter associated with hyperthyroidism. It is a common cause of hyperthyroidism in which there is excess production of thyroid hormones from functionally autonomous thyroid nodules, which do not require stimulation from thyroid stimulating hormone (TSH). Toxic multinodular goiter is the second most common cause of hyperthyroidism (after Graves' disease) in the developed world, whereas iodine deficiency is the most common cause of hypothyroidism in developing-world countries where the population is iodine-deficient. (Decreased iodine leads to decreased thyroid hormone.) However, iodine deficiency
Without a Trace two seasons. "Without a Trace" took place within Jerry Bruckheimer's "" universe. A crossover episode featured characters Gil Grissom from "CSI" and Jack Malone from "Without a Trace" working together to solve the same case. "Without a Trace" debuted as part of the CBS fall line-up in 2002, created by Hank Steinberg and produced by Jerry Bruckheimer. It was the first show to achieve strong ratings opposite longtime NBC hit medical drama "ER"—which, like "Without a Trace", is produced by Warner Bros. Television. The first two showrunners were Steinberg and Ed Redlich. Between seasons two and three, Redlich moved away