Iodine deficiency in China goitre. This disease causes a swelling in the neck, where the thyroid glands are, leading to impaired cognitive abilities. The child population was about 20% saturated with the disease but continues to decrease with the new initiatives. Another common IDD prevalent in China is Kashin-Beck disease. A particular outbreak in Tibet was recorded as occurring from lack of iodine. Kashin-Beck is a bone deformity endemic. Iodine deficiency, hypothyroidism, and low serum concentrations of thyroxine-binding globulin were significantly related to Kashin–Beck disease. Iodine supplemented irrigation water in combination to iodized salt helps in reducing the neonatal and infant mortality rates. The
Cernunnos deficiency Cernunnos deficiency Cernunnos deficiency is a form of combined immunodeficiency characterized by microcephaly, due to mutations in the NHEJ1 gene, it is inherited via autosomal recessive manner Management for this condition is antiviral prophylaxis and antibiotic treatment The sign and symptoms of this condition on an affected individual are as follows: In terms of genetics the condition, Cernunnos deficiency is due to a mutation in the NHEJ1 gene, it has a cytogenetic location of 2q35, while its molecular location is 219,075,324 to 219,160,865 The pathophysiology of Cernunnos deficiency begins with normal function of "Non-homologous end-joining factor 1" gene. NHEJ1 encodes