Coal in Europe production. According to IEA the coal based emissions in 1971–2008 were 303,262 Mt worldwide, 58,210 Mt (19.2%) in OECD Europe, and 5,086 Mt (1.7%) in non-OECD Europe. Europe here excludes European Russia and all the ex-Soviet states. The estimated external costs of coal carbon emissions in 2007 were €69 billion in OECD Europe and €6 billion in non-OECD Europe. The coal mining industry also has occupational hazards. In the Komi Republic, Russia, at the centre of the mining industry, occupational diseases are five time more prevalent than in the rest of the Russian Federation. Accidents are also known to happen
MT-ATP6 to cause mtDNA-associated Leigh syndrome involve MT-TL1, MT-TK, MT-TW, MT-TV, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6 and MT-CO3. Abnormalities in mitochondrial energy generation result in neurodegenerative disorders like Leigh syndrome, which is characterized by an onset of symptoms between 12 months and three years of age. The symptoms frequently present themselves following a viral infection and include movement disorders and peripheral neuropathy, as well as hypotonia, spasticity and cerebellar ataxia. Roughly half of affected patients die of respiratory or cardiac failure by the age of three. Leigh syndrome is a maternally inherited disorder and its diagnosis is established through genetic