Thyroid hormones which causes the thyroid to enlarge (the resulting medical condition is called "endemic colloid goitre"; see goitre). This has the effect of increasing the thyroid's ability to trap more iodide, compensating for the iodine deficiency and allowing it to produce adequate amounts of thyroid hormone. Most of the thyroid hormone circulating in the blood is bound to "transport protein"s. Only a very small fraction of the circulating hormone is free (unbound) and biologically active, hence measuring concentrations of free thyroid hormones is of great diagnostic value. When thyroid hormone is bound, it is not active, so the amount of free
Without a Trace two seasons. "Without a Trace" took place within Jerry Bruckheimer's "" universe. A crossover episode featured characters Gil Grissom from "CSI" and Jack Malone from "Without a Trace" working together to solve the same case. "Without a Trace" debuted as part of the CBS fall line-up in 2002, created by Hank Steinberg and produced by Jerry Bruckheimer. It was the first show to achieve strong ratings opposite longtime NBC hit medical drama "ER"—which, like "Without a Trace", is produced by Warner Bros. Television. The first two showrunners were Steinberg and Ed Redlich. Between seasons two and three, Redlich moved away