Uranium ore for silver in the 16th century. F.E. Brückmann made the first mineralogical description of the mineral in 1727 and the vein deposit Jachymov in the Czech Republic became the type locality for uraninite. In 1789 the German chemist M. H. Klaproth discovered the element of uranium in a sample of pitchblende from the Johanngeorgenstadt vein deposit. The first industrial production of uranium was made from the Jachymov deposit and Marie and Pierre Curie used the tailings of the mine for their discovery of polonium and radium. Vein deposits consist of uranium minerals filling in cavities such as cracks, veins, fractures,
Depleted uranium Depleted uranium has been used in a number of sampling calorimeters (such as in the D0 and ZEUS detectors) due to its high density and natural radioactivity. Normal functioning of the kidney, brain, liver, heart, and numerous other systems can be affected by uranium exposure because, in addition to being weakly radioactive, uranium is a toxic metal, although less toxic than other heavy metals, such as arsenic and mercury. It is weakly radioactive but is 'persistently' so because of its long half-life. The Agency for Toxic Substances and Disease Registry states that: "to be exposed to radiation from uranium, you