Goitre related to hypermetabolism, (increased metabolism), excessive thyroid hormone, an increase in oxygen consumption, metabolic changes in protein metabolism, immunologic stimulation of diffuse goitre, and ocular changes (exophthalmos). Hypothyroid individuals may have weight gain despite poor appetite, cold intolerance, constipation and lethargy. However, these symptoms are often non-specific and make diagnosis difficult. A goitre may be classified either as nodular or diffuse. Nodular goitres are either of one nodule (uninodular) or of multiple nodules (multinodular). Worldwide, the most common cause for goitre is iodine deficiency, usually seen in countries that do not use iodized salt. Selenium deficiency is also considered a
Leave a Trace her feelings and finding closure, and delivering a sweet vocal that drills deep into the pleasure centres." Abby Johnston of "The Austin Chronicle" called Mayberry's performance in the song "at the level of a modern-day Cyndi Lauper." "Rolling Stone" placed "Leave a Trace" at number 24 on its list of the 50 Best Songs of 2015. "Billboard" ranked "Leave a Trace" at number fourteen on its year-end list: "On 'Leave a Trace', Iain Cook and Martin Doherty’s fine-tuned swirls of synthesizer are just begging for a killer hook, and Mayberry -- singing with more swagger than ever before -- hammers