Endemic goitre by significant compression of nearby structures. Endemic goitre Endemic goiter is a type of goitre that is associated with dietary iodine deficiency. Some inland areas where soil and water lacks in iodine compounds and consumption of marine foods is low are known for higher incidence of goitre. In such areas goitre is said to be "endemic". This type of goiter is easily preventable. In most developed countries regulations have been put into force by health policy institutions requiring salt, flour or water to be fortified with iodine. Treatment of endemic goiter is medical with iodine and thyroxine preparations. Surgery is
Protein S deficiency C cofactor activity Among the possible presentation of protein S deficiency are: In terms of the cause of protein S deficiency it can be in "inherited" via autosomal dominance.A mutation in the PROS1 gene triggers the condition. The cytogenetic location of the gene in question is chromosome 3, specifically 3q11.1 Protein S deficiency can also be "acquired" due to vitamin K deficiency, treatment with warfarin, liver disease, and acute thrombosis (antiphospholipid antibodies may also be a cause as well) In regards to the mechanism of protein S deficiency, Protein S is principally made in liver cells. Protein S is a