Afonso I, Duke of Braganza time, to his first cousin once removed, Constance of Noronha, daughter of Alfonso Enríquez, Count of Gijón and Noreña (a natural son of Henry II of Castile), and of Isabel of Portugal (a natural daughter of Fernando I of Portugal). They had no issue. Afonso I, Duke of Braganza Dom Afonso I of Braganza (; 10 August 1377 – 15 December 1461) was the first Duke of Braganza and the eighth Count of Barcelos. He would start a dynasty, the House of Braganza, that would end up being the most powerful and wealthy in all of Portugal. His descendants would
Teodósio I, Duke of Braganza Teodósio I, Duke of Braganza Dom Teodósio I of Braganza (; 1510 – 22 September 1563) was the 5th Duke of Braganza, among other titles. He is known for ceding the title of Duke of Guimarães to Infante Duarte of Aviz, alongside some of the wealth and properties of the House of Braganza. The Duke Teodósio I was an educated and refined man, a typical renaissance prince. He loved painting and sculpture. In 1542, he married his 1st cousin (1513–1558), daughter of his uncle Dinis, and had John I of Braganza. Their child, João I succeeded him as 6th Duke