Goitre in 1835. The German Karl Adolph von Basedow also independently reported the same constellation of symptoms in 1840, while earlier reports of the disease were also published by the Italians Giuseppe Flajani and Antonio Giuseppe Testa, in 1802 and 1810 respectively, and by the English physician Caleb Hillier Parry (a friend of Edward Jenner) in the late 18th century. Paracelsus (1493–1541) was the first person to propose a relationship between goitre and minerals (particularly lead) in drinking water. Iodine was later discovered by Bernard Courtois in 1811 from seaweed ash. Goitre was previously common in many areas that were deficient
The Trace (Land Between the Lakes) The Trace (Land Between the Lakes) The Woodlands Trace National Scenic Byway, also known as "The Trace," is the major north–south roadway that traverses the Land Between the Lakes National Recreation Area in two counties in western Kentucky and northwestern Stewart County in northwest Middle Tennessee. It is estimated to be in length. The road is part of the National Scenic Byway system. Although it is not signed, it is listed on LBL's road logs as FD-100. The road is called "The Trace", which is what many roads and paths were called in pioneer times. "Trace" is short for "Buffalo