Jáchymov 227 zentners [11.35 tonnes] were produced), nickel, bismuth and uranium ore were also extracted. There were also other industries: an enormous tobacco factory employed 1,000 women. In addition, there was the manufacture of gloves and corks and of bobbin lace. On 31 March 1873 the town almost entirely burnt down. At the end of the 19th century, Marie Curie discovered, in tons of pitchblende ore containing uraninite from Joachimsthal, the element radium, for which she won the Nobel Prize in Chemistry. Until the First World War this was the foremost source of radium in the world. The first radon spa
Uranium weakly radioactive, uranium is a toxic metal. Uranium is also a reproductive toxicant. Radiological effects are generally local because alpha radiation, the primary form of U decay, has a very short range, and will not penetrate skin. Alpha radiation from inhaled uranium has been demonstrated to cause lung cancer in exposed nuclear workers. Uranyl () ions, such as from uranium trioxide or uranyl nitrate and other hexavalent uranium compounds, have been shown to cause birth defects and immune system damage in laboratory animals. While the CDC has published one study that no human cancer has been seen as a result