Goitre in 1835. The German Karl Adolph von Basedow also independently reported the same constellation of symptoms in 1840, while earlier reports of the disease were also published by the Italians Giuseppe Flajani and Antonio Giuseppe Testa, in 1802 and 1810 respectively, and by the English physician Caleb Hillier Parry (a friend of Edward Jenner) in the late 18th century. Paracelsus (1493–1541) was the first person to propose a relationship between goitre and minerals (particularly lead) in drinking water. Iodine was later discovered by Bernard Courtois in 1811 from seaweed ash. Goitre was previously common in many areas that were deficient
Pseudo-goitre Pseudo-goitre Pseudo-goitre is the apparent fullness of the front part of the neck. It may be mistakenly diagnosed as thyroid enlargement. The cause for pseudogoitre can be fat tissue of the neck, cervical lordosis, cervical masses (such as cervical lymphadenopathy, branchial cleft cyst, pharyngeal diverticulum) or high lying thyroid or trachea. Pseudogoitre due to cervical lordosis (swan shaped-neck) is called Modigliani syndrome after the artist Amedeo Modigliani, who was famous for painting women with exaggerated curved neck. Pseudogoitre can be distinguished from other disease conditions of the neck by physical examination. Normal thyroid moves up with swallowing, and any structure