Polonium the Curies while they were investigating the cause of pitchblende radioactivity. Pitchblende, after removal of the radioactive elements uranium and thorium, was more radioactive than the uranium and thorium combined. This spurred the Curies to search for additional radioactive elements. They first separated out polonium from pitchblende in July 1898, and five months later, also isolated radium. German scientist Willy Marckwald successfully isolated 3 milligrams of polonium in 1902, though at the time he believed it was a new element, which he dubbed "radio-tellurium", and it was not until 1905 that it was demonstrated to be the same as polonium.
Uranium trioxide which operates at the world's largest uranium refinery at Blind River, Ontario, produces high-purity uranium trioxide. It has been reported that the corrosion of uranium in a silica rich aqueous solution forms uranium dioxide, uranium trioxide, and coffinite. In pure water, schoepite (UO)O(OH)·12(HO) is formed in the first week and then after four months studtite (UO)O·4(HO) was produced. This alteration of uranium oxide also leads to the formation of metastudtite, Like all hexavalent uranium compounds, UO is hazardous by inhalation, ingestion, and through skin contact. It is a poisonous, slightly radioactive substance, which may cause shortness of breath, coughing, acute