Thyroid hormones which causes the thyroid to enlarge (the resulting medical condition is called "endemic colloid goitre"; see goitre). This has the effect of increasing the thyroid's ability to trap more iodide, compensating for the iodine deficiency and allowing it to produce adequate amounts of thyroid hormone. Most of the thyroid hormone circulating in the blood is bound to "transport protein"s. Only a very small fraction of the circulating hormone is free (unbound) and biologically active, hence measuring concentrations of free thyroid hormones is of great diagnostic value. When thyroid hormone is bound, it is not active, so the amount of free
Aromatase deficiency the low oestrogen will predispose those with the condition to osteoporosis. Symptoms are generally manifested in adulthood: During gestation, a baby with Aromatase Deficiency can cause a mother to become virilised by causing the deepening of the voice, cystic acne, cliteromegaly, and hirsutism. The mother also has an increased level of circulating testosterone. However, the symptoms normally regress post-partum. Aromatase deficiency is an autosomal recessive disease with most of the mutations occur along the highly conservative regions of the gene. Both homozygous and heterozygous mutations have been identified along various location of the exon on the P450 arom (CYP19) gene