Elbrus-2S+ Elbrus-2S+ Elbrus-2S+ () is a multi-core microprocessor based on the Elbrus 2000 architecture developed by Moscow Center of SPARC Technologies (MCST) There are multiple reports regarding the evolution of this technology for the purpose of import substitution in Russia, which was raised by several ministries on July 2014, due to economic sanctions in response to 2014 pro-Russian unrest in Ukraine. In December 2014, it was announced that Mikron start pilot production of a dual-core variant of this microprocessor called Elbrus-2SM () using a 90 nanometer CMOS manufacturing process in Zelenograd, Russia. The Elbrus-4S CPU is reported to have built in
MT-ND3 mtDNA-associated Leigh syndrome, as are variants of MT-ATP6, MT-TL1, MT-TK, MT-TW, MT-TV, MT-ND1, MT-ND2, MT-ND4, MT-ND5, MT-ND6 and MT-CO3. Abnormalities in mitochondrial energy generation result in neurodegenerative disorders like Leigh syndrome, which is characterized by an onset of symptoms between 12 months and three years of age. The symptoms frequently present themselves following a viral infection and include movement disorders and peripheral neuropathy, as well as hypotonia, spasticity and cerebellar ataxia. Roughly half of affected patients die of respiratory or cardiac failure by the age of three. Leigh syndrome is a maternally inherited disorder and its diagnosis is established through