Kingdom of France Spain and the Holy Roman Empire during the Thirty Years' War (1618–48) which had broken out in Germany. After the death of both king and cardinal, the Peace of Westphalia (1648) secured universal acceptance of Germany's political and religious fragmentation, but the Regency of Anne of Austria and her minister Cardinal Mazarin experienced a civil uprising known as the Fronde (1648–1653) which expanded into a Franco-Spanish War (1653–59). The Treaty of the Pyrenees (1659) formalised France's seizure (1642) of the Spanish territory of Roussillon after the crushing of the ephemeral Catalan Republic and ushered a short period of peace. The
Piracy in the Caribbean of the Americas all beckoned to those eager to make their fortunes and a large assortment of Frenchmen and Englishmen began new colonial ventures during the early 17th century, both in North America, which lay basically empty of European settlement north of Mexico, and in the Caribbean, where Spain remained the dominant power until late in the century. As for the Dutch Netherlands, after decades of rebellion against Spain fueled by both Dutch nationalism and their staunch Protestantism, independence had been gained in all but name (and that too would eventually come with the Treaty of Westphalia in 1648). The