Elbrus-2S+ In December 2014, an implementation of the OpenGL 3.3 standard was demonstrated by running the game "Doom 3" BFG Edition on an Elbrus-4S, clocked at 720 MHz, using a Radeon graphics card with 2 gigabytes of video memory. In April 2015, MCST announced two new products based on the Elbrus-4S CPU: One 19-inch rack server with four CPUs (16 cores) and one personal computer. In December 2015, the first shipment of PCs based on VLIW CPU Elbrus-4s was made in Russia. Elbrus-2S+ Elbrus-2S+ () is a multi-core microprocessor based on the Elbrus 2000 architecture developed by Moscow Center of SPARC
MT-ND4L are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH). The flow of electrons changes the redox state of the protein, resulting in a conformational change and p"K" shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. Mitochondrial dysfunction resulting from variants of MT-ND4L, MT-ND1 and MT-ND2 have been linked to BMI in adults and implicated in metabolic disorders including obesity, diabetes and hypertension. A T>C mutation at position 10,663 in the mitochondrial gene MT-ND4L is known to