Brazil Brazil. However, the decentralized and unorganized tendencies of the captaincy colonies proved problematic, and in 1549 the Portuguese king restructured them into the Governorate General of Brazil, a single and centralized Portuguese colony in South America. In the first two centuries of colonization, Indigenous and European groups lived in constant war, establishing opportunistic alliances in order to gain advantages against each other. By the mid-16th century, cane sugar had become Brazil's most important export, and slaves purchased in Sub-Saharan Africa, in the slave market of Western Africa (not only those from Portuguese allies of their colonies in Angola and Mozambique),
Uruguay were later proven to be from sewage discharge from the town of Gualeguaychú in Argentina. In November 2010, Uruguay and Argentina announced they had reached a final agreement for joint environmental monitoring of the pulp mill. Brazil and Uruguay have signed cooperation agreements on defence, science, technology, energy, river transportation and fishing, with the hope of accelerating political and economic integration between these two neighbouring countries. Uruguay has two uncontested boundary disputes with Brazil, over Isla Brasilera and the Invernada River region near Masoller. The two countries disagree on which tributary represents the legitimate source of the Quaraí/Cuareim River, which