Elbrus Race Anatoly, Valery and Alexandr gone as well and Elbrus Race of the first edition has stopped. Taking into consideration the increase of the popularity of extreme sport and mountaineering in Russia, the accommodation convenience in Elbrus region, the experience in organization of sport events, Russianclimb.com and Top Sport Travel (high venture travel company, led by Nikolay Shustrov (Master of Sports in mountaineering, member of Balyberdin climbing team, 1990 Elbrus Race participant with 5-th result -2h12min, Camel Trophy 93 participant) decided to reborn the tradition of speed climb competitions to the highest Europe point. So since 2005 second edition is going
MT-ND4L are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH). The flow of electrons changes the redox state of the protein, resulting in a conformational change and p"K" shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. Mitochondrial dysfunction resulting from variants of MT-ND4L, MT-ND1 and MT-ND2 have been linked to BMI in adults and implicated in metabolic disorders including obesity, diabetes and hypertension. A T>C mutation at position 10,663 in the mitochondrial gene MT-ND4L is known to