Polonium the Curies while they were investigating the cause of pitchblende radioactivity. Pitchblende, after removal of the radioactive elements uranium and thorium, was more radioactive than the uranium and thorium combined. This spurred the Curies to search for additional radioactive elements. They first separated out polonium from pitchblende in July 1898, and five months later, also isolated radium. German scientist Willy Marckwald successfully isolated 3 milligrams of polonium in 1902, though at the time he believed it was a new element, which he dubbed "radio-tellurium", and it was not until 1905 that it was demonstrated to be the same as polonium.
Depleted uranium Depleted uranium has been used in a number of sampling calorimeters (such as in the D0 and ZEUS detectors) due to its high density and natural radioactivity. Normal functioning of the kidney, brain, liver, heart, and numerous other systems can be affected by uranium exposure because, in addition to being weakly radioactive, uranium is a toxic metal, although less toxic than other heavy metals, such as arsenic and mercury. It is weakly radioactive but is 'persistently' so because of its long half-life. The Agency for Toxic Substances and Disease Registry states that: "to be exposed to radiation from uranium, you