Kingdom of France Spain and the Holy Roman Empire during the Thirty Years' War (1618–48) which had broken out in Germany. After the death of both king and cardinal, the Peace of Westphalia (1648) secured universal acceptance of Germany's political and religious fragmentation, but the Regency of Anne of Austria and her minister Cardinal Mazarin experienced a civil uprising known as the Fronde (1648–1653) which expanded into a Franco-Spanish War (1653–59). The Treaty of the Pyrenees (1659) formalised France's seizure (1642) of the Spanish territory of Roussillon after the crushing of the ephemeral Catalan Republic and ushered a short period of peace. The
Seventeen Provinces during the Eighty Years' War (see Generality Lands), which ended with the Treaty of Westphalia in 1648. Artois and parts of Flanders and Hainaut (French Flanders and French Hainaut) were ceded to France in the course of the 17th and 18th centuries. By the mid-16th century, the Margraviate of Antwerp (Duchy of Brabant) had become the economic, political, and cultural center of the Netherlands after its capital had shifted from the nearby Lordship of Mechelen to the city of Brussels. Bruges (County of Flanders) had already lost its prominent position as economic powerhouse of northern Europe. And Holland was gradually