Goitre related to hypermetabolism, (increased metabolism), excessive thyroid hormone, an increase in oxygen consumption, metabolic changes in protein metabolism, immunologic stimulation of diffuse goitre, and ocular changes (exophthalmos). Hypothyroid individuals may have weight gain despite poor appetite, cold intolerance, constipation and lethargy. However, these symptoms are often non-specific and make diagnosis difficult. A goitre may be classified either as nodular or diffuse. Nodular goitres are either of one nodule (uninodular) or of multiple nodules (multinodular). Worldwide, the most common cause for goitre is iodine deficiency, usually seen in countries that do not use iodized salt. Selenium deficiency is also considered a
The Trace (Land Between the Lakes) The Trace (Land Between the Lakes) The Woodlands Trace National Scenic Byway, also known as "The Trace," is the major north–south roadway that traverses the Land Between the Lakes National Recreation Area in two counties in western Kentucky and northwestern Stewart County in northwest Middle Tennessee. It is estimated to be in length. The road is part of the National Scenic Byway system. Although it is not signed, it is listed on LBL's road logs as FD-100. The road is called "The Trace", which is what many roads and paths were called in pioneer times. "Trace" is short for "Buffalo