Coal in Europe production. According to IEA the coal based emissions in 1971–2008 were 303,262 Mt worldwide, 58,210 Mt (19.2%) in OECD Europe, and 5,086 Mt (1.7%) in non-OECD Europe. Europe here excludes European Russia and all the ex-Soviet states. The estimated external costs of coal carbon emissions in 2007 were €69 billion in OECD Europe and €6 billion in non-OECD Europe. The coal mining industry also has occupational hazards. In the Komi Republic, Russia, at the centre of the mining industry, occupational diseases are five time more prevalent than in the rest of the Russian Federation. Accidents are also known to happen
MT-ND4L are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH). The flow of electrons changes the redox state of the protein, resulting in a conformational change and p"K" shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. Mitochondrial dysfunction resulting from variants of MT-ND4L, MT-ND1 and MT-ND2 have been linked to BMI in adults and implicated in metabolic disorders including obesity, diabetes and hypertension. A T>C mutation at position 10,663 in the mitochondrial gene MT-ND4L is known to