Deaf climbers with an artificial leg, and a person with epilepsy. Only two of the individuals in the group did not reach the summit. Heidi Zimmer is the first deaf woman to reach the summit of Mt. McKinley in Alaska. She is the first deaf individual to reach the summit of Mt. Kilimanjaro in Africa, as well as Mt. Elbrus in the Republic of Russia which has an elevation of 18,510 feet. She has a goal of completing the seven summits which consist of the highest peak in each continent. This is considered a huge accomplishment in the climbing world. Yasayuki Okobu,
MT-ND4L are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH). The flow of electrons changes the redox state of the protein, resulting in a conformational change and p"K" shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. Mitochondrial dysfunction resulting from variants of MT-ND4L, MT-ND1 and MT-ND2 have been linked to BMI in adults and implicated in metabolic disorders including obesity, diabetes and hypertension. A T>C mutation at position 10,663 in the mitochondrial gene MT-ND4L is known to