Iodine deficiency Iodine deficiency Iodine deficiency is a lack of the trace element iodine, an essential nutrient in the diet. It may result in a goiter, sometimes as an endemic goiter as well as cretinism due to untreated congenital hypothyroidism, which results in developmental delays and other health problems. Iodine deficiency is an important public health issue as it is a preventable cause of intellectual disability. Iodine is an essential dietary mineral; the thyroid hormones thyroxine and triiodothyronine contain iodine. In areas where there is little iodine in the diet, typically remote inland areas where no marine foods are eaten, iodine deficiency
ZAP70 deficiency ZAP70 deficiency ZAP70 deficiency, or ZAP70 deficient SCID, is a rare autosomal recessive form of severe combined immunodeficiency (SCID) resulting in a lack of CD8+ T cells. People with this disease lack the capability to fight infections, and it is fatal if untreated. It is cause by a mutation in the ZAP70 gene. Children with this condition typically present with infections and skin rashes. Unlike many forms of SCID, absolute lymphocyte count is normal and thymus is present. ZAP70 deficiency SCID is caused by a mutation is the ZAP70 gene, which is involved in the development of T cells. It