Iodine deficiency in China goitre. This disease causes a swelling in the neck, where the thyroid glands are, leading to impaired cognitive abilities. The child population was about 20% saturated with the disease but continues to decrease with the new initiatives. Another common IDD prevalent in China is Kashin-Beck disease. A particular outbreak in Tibet was recorded as occurring from lack of iodine. Kashin-Beck is a bone deformity endemic. Iodine deficiency, hypothyroidism, and low serum concentrations of thyroxine-binding globulin were significantly related to Kashin–Beck disease. Iodine supplemented irrigation water in combination to iodized salt helps in reducing the neonatal and infant mortality rates. The
ZC4H2 deficiency neurological manifestations. These can include: To date, there is no cure or effective treatment for this condition. Current approach is limited to supportive therapies and interventions. ZC4H2 deficiency ZC4H2 (Zinc finger C4H2-type) is a protein-coding gene located on the X-chromosome. This gene encodes a protein which is a member of the so-called zinc finger domain-containing protein family. There is currently very limited understanding about the ZC4H2 gene and its protein function. Any pathogenic variant of ZC4H2 which is associated with a clinical phenotype is referred to as "ZC4H2 Deficiency". The limited research published to date indicates that ZC4H2 is expressed