Real Betis happened in 1928–29, with both teams winning their home matches (3–0 and 2–1). They played for the first time in the Spanish top division during the 1934–35 season, with a 0–3 home defeat for Sevilla and a 2–2 draw at Betis, with the latter winning the national championship. On 17 January 1943, Betis lost 5–0 at Sevilla, eventually being relegated. In the first game held at the Ramón Sánchez Pizjuán Stadium, on 21 September 1958, the "Verdiblancos" won it 4–2. In later years, several matches were also marred by violence, including: a security guard attacked by a Sevilla fan with
Real Betis after lifting the league title only two players who won in 1935 were left: Peral and Saro. No official league was held during the Civil War between 1936 and 1939, until its resumption for the 1939–40 season and the first year back highlighted Betis' decline as exactly five years after winning the title the club was relegated. Despite a brief return to the top division which lasted only one season, the club continued to decline and in 1947 the worst fears were reached when they were relegated to Tercera División. Many fans see the ten years they spent in the