Iodine in biology damage). In areas where there is little iodine in the diet, typically remote inland areas and semi-arid equatorial climates where no marine foods are eaten, iodine deficiency also gives rise to hypothyroidism, the most serious symptoms of which are epidemic goitre (swelling of the thyroid gland), extreme fatigue, mental slowing, depression, weight gain, and low basal body temperatures. The addition of iodine to table salt (so-called iodized salt) has largely eliminated the most severe consequences of iodine deficiency in wealthier nations, but deficiency remains a serious public health problem in the developing world. Iodine deficiency is also a problem in
ZAP70 deficiency ZAP70 deficiency ZAP70 deficiency, or ZAP70 deficient SCID, is a rare autosomal recessive form of severe combined immunodeficiency (SCID) resulting in a lack of CD8+ T cells. People with this disease lack the capability to fight infections, and it is fatal if untreated. It is cause by a mutation in the ZAP70 gene. Children with this condition typically present with infections and skin rashes. Unlike many forms of SCID, absolute lymphocyte count is normal and thymus is present. ZAP70 deficiency SCID is caused by a mutation is the ZAP70 gene, which is involved in the development of T cells. It