Goitre the Heavenly Husbandman", asserted that iodine-rich sargassum was used to treat goitre patients by the 1st century BC, but this book was written much later. In the 12th century, Zayn al-Din al-Jurjani, a Persian physician, provided the first description of Graves' disease after noting the association of goitre and a displacement of the eye known as exophthalmos in his "Thesaurus of the Shah of Khwarazm", the major medical dictionary of its time. Al-Jurjani also established an association between goitre and palpitation. The disease was later named after Irish doctor Robert James Graves, who described a case of goitre with exophthalmos
Pyruvate carboxylase deficiency Pyruvate carboxylase deficiency Pyruvate carboxylase deficiency is an inherited disorder that causes lactic acid to accumulate in the blood. High levels of these substances can damage the body's organs and tissues, particularly in the nervous system. Pyruvate carboxylase deficiency is a rare condition, with an estimated incidence of 1 in 250,000 births worldwide. Type A of the disease appears to be much more common in some Algonkian Indian tribes in eastern Canada, while the type B disease is more present in European populations. Mutations in the "PC" gene cause pyruvate carboxylase deficiency. The "PC" gene provides instructions for making an