Goitre an underactive thyroid, thyroid supplements are used as treatment. Sometimes a partial or complete thyroidectomy is required. Goitre is more common among women, but this includes the many types of goitre caused by autoimmune problems, and not only those caused by simple lack of iodine. Chinese physicians of the Tang Dynasty (618–907) were the first to successfully treat patients with goitre by using the iodine-rich thyroid gland of animals such as sheep and pigs—in raw, pill, or powdered form. This was outlined in Zhen Quan's (d. 643 AD) book, as well as several others. One Chinese book, "The Pharmacopoeia of
ZC4H2 deficiency neurological manifestations. These can include: To date, there is no cure or effective treatment for this condition. Current approach is limited to supportive therapies and interventions. ZC4H2 deficiency ZC4H2 (Zinc finger C4H2-type) is a protein-coding gene located on the X-chromosome. This gene encodes a protein which is a member of the so-called zinc finger domain-containing protein family. There is currently very limited understanding about the ZC4H2 gene and its protein function. Any pathogenic variant of ZC4H2 which is associated with a clinical phenotype is referred to as "ZC4H2 Deficiency". The limited research published to date indicates that ZC4H2 is expressed