Real Betis happened in 1928–29, with both teams winning their home matches (3–0 and 2–1). They played for the first time in the Spanish top division during the 1934–35 season, with a 0–3 home defeat for Sevilla and a 2–2 draw at Betis, with the latter winning the national championship. On 17 January 1943, Betis lost 5–0 at Sevilla, eventually being relegated. In the first game held at the Ramón Sánchez Pizjuán Stadium, on 21 September 1958, the "Verdiblancos" won it 4–2. In later years, several matches were also marred by violence, including: a security guard attacked by a Sevilla fan with
Real Betis position, thus qualifying to the UEFA Cup.In the European campaign, Betis knocked out Fenerbahçe (4–1 on aggregate) and 1. FC Kaiserslautern (4–1) before losing to defeated finalists Bordeaux (3–2). In 1997, 20 years after winning the trophy for the first time, the club returned to the final of the Copa del Rey – again held in Madrid, although this time at the Santiago Bernabéu Stadium – losing 2–3 against Barcelona after extra time. Incidentally, "Barça" was the club Serra Ferrer would leave Betis for that summer, to be replaced by former player Luis Aragonés. Aragonés would only last one season