Malachite green is retained in catfish muscle longer (HL = 10 days) than is the parent molecule (HL = 2.8 days). The (oral, mouse) is 80 mg/kg. Rats fed malachite green experience "a dose-related increase in liver DNA adducts" along with lung adenomas. Leucomalachite green causes an "increase in the number and severity of changes". As leucomalachite green is the primary metabolite of malachite green and is retained in fish muscle much longer, most human dietary intake of malachite green from eating fish would be in the leuco form. During the experiment, rats were fed up to 543 ppm of leucomalachite green,
The Malachite Box was presented to the author for his 60th birthday on 28 January 1939. Several test copies were published in January. A special deluxe edition, decorated with malachite, was sent to the 1939 New York World's Fair. The mass market edition published in autumn of the same year. The book was an instant success. It has been republished many times. Overall, twenty three editions of the stories were released from 1941 to 1945. The second edition of the collection was released by the Moscow publishing house Sovetsky Pisatel in 1942. The book was awarded the Stalin prize. The third edition of