Mitral valve prolapse systole is known as a holo-systolic murmur. A murmur that is mid to late systolic, although typically associated with less regurgitation, can still be associated with significant hemodynamic consequences. In contrast to most other heart murmurs, the murmur of mitral valve prolapse is accentuated by standing and valsalva maneuver (earlier systolic click and longer murmur) and diminished with squatting (later systolic click and shorter murmur). The only other heart murmur that follows this pattern is the murmur of hypertrophic cardiomyopathy. A MVP murmur can be distinguished from a hypertrophic cardiomyopathy murmur by the presence of a mid-systolic click which is
Mitral valve the left ventricle. It has two leaflets (or 'cusps'), an anteromedial leaflet, and a posterolateral leaftlet. The opening of the mitral valve is surrounded by a fibrous ring known as the "mitral annulus". The anterior cusp covers approximately two-thirds of the valve (imagine a crescent moon within the circle, where the crescent represents the posterior cusp). Although the anterior leaflet takes up a larger part of the ring and rises higher, the posterior leaflet has a larger surface area. The valve leaflets are prevented from prolapsing into the left atrium by the action of chordae tendineae. The chordae tendineae are