Earwax in the canal. Jaw movement assists this process by dislodging debris attached to the walls of the ear canal, increasing the likelihood of its expulsion. The lubrication provided by cerumen prevents desiccation of the skin within the ear canal. The lubricative properties arise from the high lipid content of the sebum produced by the sebaceous glands. In wet-type cerumen, these lipids include cholesterol, squalene, and many long-chain fatty acids and alcohols. While studies conducted up until the 1960s found little evidence supporting antibacterial activity for cerumen, more recent studies have found that cerumen has a bactericidal effect on some strains
Blood vessel epicardial substance malignancy. Bves is underexpressed in colon, lung, and breast cancer. In colon cancer this occurs very early during tumorigenesis, with Bves underexpression first noted in premalignant adenomas. Blood vessel epicardial substance Blood vessel epicardial substance (BVES) also known as popeye domain-containing protein 1 (POPDC1) is a protein that in humans is encoded by the "BVES" gene. Bves is a highly conserved, transmembrane protein that is involved in cell adhesion, cell motility, and most recently has been shown to play a role in vesicular transport. Bves is found in a wide variety of organisms (from flies to humans) and is a