Malachite green is retained in catfish muscle longer (HL = 10 days) than is the parent molecule (HL = 2.8 days). The (oral, mouse) is 80 mg/kg. Rats fed malachite green experience "a dose-related increase in liver DNA adducts" along with lung adenomas. Leucomalachite green causes an "increase in the number and severity of changes". As leucomalachite green is the primary metabolite of malachite green and is retained in fish muscle much longer, most human dietary intake of malachite green from eating fish would be in the leuco form. During the experiment, rats were fed up to 543 ppm of leucomalachite green,
The Malachite Box to other issues, such as beauty and ugliness, life and death, order and chaos, eroticism, the relationship of people with nature and the Mountain, the mysterious in general, the place of the person in the world. Lidiya Slobozhaninova summarizes that some parts of "The Malachite Box" "become outdated, but others gain new meaning". The stories from the collection inspired numerous adaptations, including films, radio and stage adaptations. The Soviet poet Demyan Bedny was so impressed with the tales that he decided to adapt them into poetry. He began the work on 27 June 1939 and adapted the 14 original stories