Vitamin K deficiency thus activate) certain enzymes involved in coagulation: Factors II, VII, IX, X, and protein C and protein S. Inability to activate the clotting cascade via these factors leads to the bleeding symptoms mentioned above. Notably, when one examines the lab values in Vitamin K deficiency [see below] the prothrombin time is elevated, but the partial thromboplastin time is normal or only mildly prolonged. This may seem counterintuitive given that the deficiency leads to decreased activity in factors of both the intrinsic pathway (F-IX) which is monitored by PTT, as well as the extrinsic pathway (F-VII) which is monitored by PT.
Vitamin D deficiency in Australia deformities, hypocalcemia, tetany and seizures. During the late 19th century autopsies conducted in the Netherlands concluded that 80-90% of children were suffering from Rickets. The incidents of rickets observed within Sydney hospitals during the years of 2003 – 2004 have doubled. This major spike can be attributed to the growing population of migrants in Australia, many of whom are considered high risk of vitamin D deficiency. As shown in the image the skeletal deformities such as knock knees and bow legs in these young children as a result of rickets. Because of the high prevalence of vitamin D deficiency, conditions