Mitral valve stenosis Mitral valve stenosis Mitral stenosis is a valvular heart disease characterized by the narrowing of the orifice of the mitral valve of the heart. Signs and symptoms of mitral stenosis include the following: Fatigue and weakness increase with exercise and pregnancy. The natural history of mitral stenosis secondary to rheumatic fever (the most common cause) is an asymptomatic latent phase following the initial episode of rheumatic fever. This latent period lasts an average of 16.3 ± 5.2 years. Once symptoms of mitral stenosis begin to develop, progression to severe disability takes 9.2 ± 4.3 years. In individuals having been offered
Mitral valve stenosis infective endocarditis where the vegetations may favor increase risk of stenosis. Other rare causes include mitral annular calcification, endomyocardial fibroelastosis, malignant carcinoid syndrome, systemic lupus erythematosus, whipple disease, fabry disease, and rheumatoid arthritis. hurler' disease, hunter's disease, amyloidosis. The normal area of the mitral valve orifice is about 4 to 6 cm. In normal cardiac physiology, the mitral valve opens during left ventricular diastole, to allow blood to flow from the left atrium to the left ventricle. A normal mitral valve will not impede the flow of blood from the left atrium to the left ventricle during (ventricular) diastole, and