Inland taipan may include headache, nausea, vomiting, abdominal pain, diarrhoea, dizziness, collapse or convulsions leading to major organ effects: neurotoxicity, coagulopathy, rhabdomyolysis or renal failure/damage and finally death. Inland taipan snake venom contains potent presynaptic neurotoxins (toxins in venom that cause paralysis or muscle weakness). Also present are postsynaptic neurotoxins, which are less potent but more rapid acting than the presynaptic neurotoxins. Presynaptic neurotoxins disrupt neurotransmitter release from the axon terminal. This takes days to resolve and does not respond to antivenom. Postsynaptic neurotoxins competitively block acetylcholine receptors but the effect can be reversed by antivenom. Neurotoxic envenoming causes a progressive descending
Inland taipan Cook University, the majority of components in the venom have not been characterized and little molecular research has been undertaken on taipan ("Oxyuranus") species at large. As of 2005, the amino acid sequences of only seven proteins from inland taipan have been submitted to SWISS-PROT databases. The mortality rate is high in untreated cases: Clinically, envenomation may represent a complex scenario of multiple organ system poisoning with neurotoxic symptoms typically dominating. Acute renal failure, rhabdomyolysis, and disseminated coagulopathy may also complicate the setting. The first local and general symptoms of a bite are local pain and variable non-specific effects which