Earwax of bacteria. Cerumen has been found to reduce the viability of a wide range of bacteria, including "Haemophilus influenzae", "Staphylococcus aureus", and many variants of "Escherichia coli", sometimes by as much as 99%. The growth of two fungi commonly present in otomycosis was also significantly inhibited by human cerumen. These antimicrobial properties are due principally to the presence of saturated fatty acids, lysozyme and, especially, to the slight acidity of cerumen (pH typically around 6.1 in normal individuals). Conversely, other research has found that cerumen can support microbial growth and some cerumen samples were found to have bacterial counts as
What Is and What Should Never Be (Supernatural) creepy look to it". He was pleased to see Smith and Palicki return, and found the character of Carmen to be "a nice addition to the family". Don Williams of BuddyTV agreed, and ranked the episode third in his list of the best episodes of the first three seasons. Deeming it the best standalone episode, he noted that it "can be embraced by anyone who enjoys clever writing, great acting, or a shirtless Jensen Ackles". General Specific Notes What Is and What Should Never Be (Supernatural) "What Is and What Should Never Be" is the twentieth episode of the paranormal