Malachite green is retained in catfish muscle longer (HL = 10 days) than is the parent molecule (HL = 2.8 days). The (oral, mouse) is 80 mg/kg. Rats fed malachite green experience "a dose-related increase in liver DNA adducts" along with lung adenomas. Leucomalachite green causes an "increase in the number and severity of changes". As leucomalachite green is the primary metabolite of malachite green and is retained in fish muscle much longer, most human dietary intake of malachite green from eating fish would be in the leuco form. During the experiment, rats were fed up to 543 ppm of leucomalachite green,
The Malachite Box by critics and enthusiastically received by readers, including the general populace and the more sophisticated Soviet intelligentsia. Bazhov turned into one of the most famous writers in the Soviet Union. Strangers would greet him on the streets. The critics agreed that "never has the labour of miners, stone-cutters, teemers been celebrate in such a way, neither in verses, nor in prose", and that Bazhov managed to show the essence of the professional skill of the miners. Mikhail Batin complimented its uniqueness, and novelty in the contents and in the form. Favourable reviews on "The Malachite Box" appeared in "Uralsky Rabochy"