Meat ant within a colony is typically favoured as it improves access to forage, as workers deliver most of their food to the nest that is closest to any site they forage in. At any size, a meat ant nest always has a possibility of dying out in any year, but the site may be reoccupied by another colony. Hence, nests can be very old as suggested in one study. Some nests may never be reoccupied for unknown reasons. The regrowth of vegetation which shades the nest, soil damage or even a disease may wipe out a colony and leave the nest
Leafcutter ant virulent fungus, has the potential to devastate an ant garden, as it is horizontally transmitted. "Escovopsis" was cultured, during colony foundation, in 6.6% of colonies. However, in one- to two-year-old colonies, almost 60% had "Escovopsis" growing in the fungal garden. In some parts of their range, leafcutter ants can be a serious agricultural pest, defoliating crops and damaging roads and farmland with their nest-making activities. For example, some "Atta" species are capable of defoliating an entire citrus tree in less than 24 hours. A promising approach to deterring attacks of the leafcutter ant "Acromyrmex lobicornis" on crops has been demonstrated.