Earwax of bacteria. Cerumen has been found to reduce the viability of a wide range of bacteria, including "Haemophilus influenzae", "Staphylococcus aureus", and many variants of "Escherichia coli", sometimes by as much as 99%. The growth of two fungi commonly present in otomycosis was also significantly inhibited by human cerumen. These antimicrobial properties are due principally to the presence of saturated fatty acids, lysozyme and, especially, to the slight acidity of cerumen (pH typically around 6.1 in normal individuals). Conversely, other research has found that cerumen can support microbial growth and some cerumen samples were found to have bacterial counts as
Substance theory bundle theorist objects to the notion of a thing with no properties, claiming that such a thing is inconceivable and citing John Locke, who described a substance as "a something, I know not what." To the bundle theorist, as soon as one has any notion of a substance in mind, a property accompanies that notion. The indiscernibility argument from the substance theorist targets those bundle theorists who are also metaphysical realists. Metaphysical realism uses the identity of "universals" to compare and identify particulars. Substance theorists say that bundle theory is incompatible with metaphysical realism due to the identity of indiscernibles: