Scurvy -gulonolactone oxidase (GULO) enzyme, which is required in the last step of vitamin C synthesis. The genomes of these species contain GULO as pseudogenes, which serve as insight into the evolutionary past of the species. In babies, scurvy is sometimes referred to as Barlow's disease, named after Thomas Barlow, a British physician who described it in 1883. However, Barlow's disease or Barlow's syndrome may also refer to mitral valve prolapse, first described by John Brereton Barlow in 1966. Scurvy Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms include weakness, feeling tired, and sore
Vitamin A deficiency and lymphocytes. Suppression of these result in a lack of immune reaction if pathogens become present in the body and consequently a greater susceptibility to incubation of disease. VAD and infections aggravate each other, so with infection, vitamin A levels are depleted, which in turn reduces intestinal absorption of vitamin A. Very often seen with VAD is protein energy malnutrition, in which the synthesis of retinol binding protein (RBP) is decreased, consequently the uptake of retinol is reduced. This leads to an inability to use any vitamin A present as the RBP is absent, so the retinol cannot be transported