Malachite green is retained in catfish muscle longer (HL = 10 days) than is the parent molecule (HL = 2.8 days). The (oral, mouse) is 80 mg/kg. Rats fed malachite green experience "a dose-related increase in liver DNA adducts" along with lung adenomas. Leucomalachite green causes an "increase in the number and severity of changes". As leucomalachite green is the primary metabolite of malachite green and is retained in fish muscle much longer, most human dietary intake of malachite green from eating fish would be in the leuco form. During the experiment, rats were fed up to 543 ppm of leucomalachite green,
Malachite The mineral was given this name due to its resemblance to the leaves of the mallow plant. Malachite was extensively mined at the Great Orme mines in Britain 3,800 years ago using stone and bone tools. Archaeological evidence indicates that mining activity ended around 600 B.C.E with up to 1,760 tonnes of copper being produced from the mined Malachite. Archaeological evidence indicates that the mineral has been mined and smelted to obtain copper at Timna Valley in Israel for over 3,000 years. Since then, malachite has been used as both an ornamental stone and as a gemstone. In ancient Egypt