Route 1 (Paraguay) near). Route 1 (Paraguay) National Route 1 (in Spanish, Ruta Nacional Número 1 "Mcal. Francisco Solano López", or simply Ruta Uno) is one of the most important and one of the first highways in Paraguay, which runs from the capital city, Asunción to Itapua Department's capital, Encarnación. Crossing the departments of Central, Paraguarí, Misiones and Itapua. It starts on Avenida Eusebio Ayala, and ends at the San Roque González de Santa Cruz Bridge, on the Paraná River, traversing . The following table shows the distances traversed by Ruta 1 in each different department, and important cities that it passes by
Revolt of the Comuneros (Paraguay) their streets and enforcing the new governor's rule. This wound never healed. By 1721, hatred of the Jesuits was even more intense than it was in the early 1600s. In 1717, Diego de los Reyes Balmaseda became governor of Paraguay. He purchased the position from the Spanish authorities, a practice that had spread at the time. Reyes was a merchant who had made his fortune trading exporting yerba mate from Paraguay and importing various cheap and needed manufactures back to Paraguay, so he was seen as qualified for the post by the Spanish Crown. Reyes was an open admirer of