Inland taipan may include headache, nausea, vomiting, abdominal pain, diarrhoea, dizziness, collapse or convulsions leading to major organ effects: neurotoxicity, coagulopathy, rhabdomyolysis or renal failure/damage and finally death. Inland taipan snake venom contains potent presynaptic neurotoxins (toxins in venom that cause paralysis or muscle weakness). Also present are postsynaptic neurotoxins, which are less potent but more rapid acting than the presynaptic neurotoxins. Presynaptic neurotoxins disrupt neurotransmitter release from the axon terminal. This takes days to resolve and does not respond to antivenom. Postsynaptic neurotoxins competitively block acetylcholine receptors but the effect can be reversed by antivenom. Neurotoxic envenoming causes a progressive descending
Creature Comforts things to come in British television advertising. Many commentators believe that there was a fundamental shift in television advertising from the unbridled consumerism and egoism of the 1980s to what is sometimes termed a more "caring" approach in the 1990s. The "Creature Comforts" advertisements are cited as an early example of this phenomenon. The format of the "Creature Comforts" advertisements was so successful that it was replicated in other campaigns in the following decades. In later years, however, members of the public became increasingly conscious of the potential uses of their "vox pop" interviews. This made it difficult to recapture