Malachite green is retained in catfish muscle longer (HL = 10 days) than is the parent molecule (HL = 2.8 days). The (oral, mouse) is 80 mg/kg. Rats fed malachite green experience "a dose-related increase in liver DNA adducts" along with lung adenomas. Leucomalachite green causes an "increase in the number and severity of changes". As leucomalachite green is the primary metabolite of malachite green and is retained in fish muscle much longer, most human dietary intake of malachite green from eating fish would be in the leuco form. During the experiment, rats were fed up to 543 ppm of leucomalachite green,
The Malachite Box total circulation of about 37 million copies. "The Malachite Box" has been republished many times since then. The tales were translated into 64 languages, more than 250 editions in foreign languages were released. The list of languages include English, Hungarian, Italian, Bulgarian, Serbo-Croatian, Mongolian, Chinese, Japanese, Assamese, Kannada. Four stories from "The Malachite Box" were published in the 1943 Moscow magazine "Internatsionalnaya Literatura" in English and French. In 1944 the book was translated from Russian into English by Alan Moray Williams and published by Hutchinson. Bazhov did not know about this translation and found out about it accidentally. In the