Mitral valve chordae attached to the posterior cusp. Advanced lesions—also commonly involving the posterior leaflet—lead to leaflet folding, inversion, and displacement toward the left atrium. A valve prolapse can result in mitral insufficiency which is a regurgitation or backflow of blood due to the incomplete closure of the valve. Rheumatic heart disease often affects the mitral valve. The valve may also be affected by infective endocarditis Surgery can be performed to replace or repair a damaged valve. A less invasive method is that of mitral valvuloplasty which uses a balloon catheter to open up a stenotic valve. Rarely there can be a
Mitral insufficiency MR and mitral valve prolapse are also common in Ehlers–Danlos syndromes. Secondary mitral insufficiency is due to the dilatation of the left ventricle that causes stretching of the mitral valve annulus and displacement of the papillary muscles. This dilatation of the left ventricle can be due to any cause of dilated cardiomyopathy including aortic insufficiency, nonischemic dilated cardiomyopathy, and Noncompaction cardiomyopathy. Because the papillary muscles, chordae, and valve leaflets are usually normal in such conditions, it is also called functional mitral insufficiency. Acute MR is most often caused by endocarditis, mainly "S. aureus". Rupture or dysfunction of the papillary muscle