Route 1 (Paraguay) Route 1 (Paraguay) National Route 1 (in Spanish, Ruta Nacional Número 1 "Mcal. Francisco Solano López", or simply Ruta Uno) is one of the most important and one of the first highways in Paraguay, which runs from the capital city, Asunción to Itapua Department's capital, Encarnación. Crossing the departments of Central, Paraguarí, Misiones and Itapua. It starts on Avenida Eusebio Ayala, and ends at the San Roque González de Santa Cruz Bridge, on the Paraná River, traversing . The following table shows the distances traversed by Ruta 1 in each different department, and important cities that it passes by (or
San Pedro Department, Paraguay San Pedro Department, Paraguay San Pedro () is a department of Paraguay. The capital is the city of San Pedro de Ycuamandiyú. During the 17th and 18th centuries there was even greater political and population instability than in Concepción. The Mbayá and Payagua native tribes threatened all the area between the Ypané (in the north) and Manduvirá (in the south) Rivers and the valley by the Jejuí River. In 1660 the natives revolted in Arecajá against the postal parcel system, causing the disappearance of this town. To help regenerate this area, the Missions San Estanislao (1749), Villa del Rosario (1786)