Dodecanese relative quiet and prosperity. In 408 BC, the three cities of Rhodes had united to form one state, which built a new capital on the northern end of the island, also named "Rhodes"; this united Rhodes was to dominate the region for the coming millennia. Other islands in the Dodecanese also developed into significant economic and cultural centers; most notably, Kos served as the site of the school of medicine founded by Hippocrates. However, the Peloponnesian War had so weakened the entire Greek civilization's military strength that it lay open to invasion. In 357 BC, the islands were conquered by
Dodecanese Greece. As a part of the 2011 Kallikratis reform, the prefecture was abolished, and its territory was divided into four regional units, within the South Aegean administrative region: The prefecture was subdivided into the following municipalities and communities. These have been reorganised at the 2011 Kallikratis reform as well. Until 1997, the Prefecture of the Dodecanese was subdivided into provinces: Local specialities of the Dodecanese include: Dodecanese The Dodecanese (, ; , "Dodekánisa" , literally "twelve islands") are a group of 15 larger plus 150 smaller Greek islands in the southeastern Aegean Sea, off the coast of Asia Minor (Turkey),