Haptic perception by metabolic, toxic and/or immunologic factors. Examples of medical conditions that can cause neuropathies are diabetes mellitus, chronic kidney disease, thyroid dysfunction (hyper- and hypothyroidism) as well as hepatitis, liver cirrhosis and alcohol dependency. Loss of the sense of touch is a catastrophic deficit that can impair walking and other skilled actions such as holding objects or using tools. Immersive environments can recreate the feeling of haptic interaction. Exoskeletal gloves such as the Exo-Skin Soft Haptic exoskeletal interface, developed at Drexel University, can be programmed to take a patient through a program of physical therapy exercises to retrain muscles and
Five wits Five wits In the time of William Shakespeare, there were commonly reckoned to be five wits and five senses. The five wits were sometimes taken to be synonymous with the five senses, but were otherwise also known and regarded as the five inward wits, distinguishing them from the five senses, which were the five "outward" wits. Much of this conflation has resulted from changes in meaning. In Early Modern English, "wit" and "sense" overlapped in meaning. Both could mean a faculty of perception (although this sense dropped from the word "wit" during the 17th century). Thus "five wits" and "five