Collared titi causes them to give alarm peeps, probably because they must be especially alert to predators. A margay was detected alongside a dead collared titi during recent censuses on the Purité River in Colombia, although the monkey was not freshly killed. The local group was no longer observed after this. The collared titi is not considered to be endangered, but where there are many colonists this primate tends to disappear, due to deforestation. The species is commonly hunted and eaten by indigenous peoples or used as bait for hunting larger carnivores or for fishing; however, where there is plenty of forest
White-eared titi be quite tolerant of habitat disturbance. In Bolivia, the white-eared titi is found in the upper parts of the Mamoré, Grande, and San Miguel river basins, east of the Manique River in Beni and in the forests surrounding the city of Santa Cruz de la Sierra. Its range extends north to southern Rondônia in Brazil. The white-eared titi is considered to be of least concern on the International Union for Conservation of Nature (IUCN) Red List. The species is not considered threatened due to its adaptability and abundance over a relatively wide range, and despite having a decreasing population trend