Rio Mayo titi this species to survive, their forests need to be protected to avoid overpopulation. Different conservation groups are working to help "P. oenanthe" survive. Neotropical Primate Conservation, Proyecto Mono Tocón and Amazónicos para la Amazonia are working in the more southern areas to protect the monkey. The Rio Mayo titi is a fairly inconspicuous creature, making observation and research difficult to obtain. Therefore, the traditional use of transect observation to monitor the monkey's population, is less effective. Instead, other methods of calculating the titi monkey's density in certain areas have been taken, such as research into the species-specific calls endemic to
Collared titi meat the species is found commonly close to Indian settlements. The species is classified "Least Concern" (formerly LR) in the IUCN Red List. Actually the Colombian black-handed titi may be slightly endangered due to its presence in a zone of heavy colonization, but presently it is classified LC with the other subspecies. Fortunately the Colombian black-handed titi is found in La Paya National Park in Colombia, although the park itself is very vulnerable to surrounding colonization. The Lucifer titi is protected in Colombia by Amacayacu National Park and Cahuinarí National Park, while the black titi may be protected in Chiribiquete