Bergamot essential oil painful erythema and bullae on exposed areas of the skin. In one case, six (6) drops of bergamot aromatherapy oil in a bath followed by 20–30 minutes exposure of ultraviolet light from a tanning bed caused a severe burn-like reaction. Bergamot essential oil contains a significant amount of bergapten, a phototoxic substance that gets its name from the bergamot orange. Bergapten, a linear furanocoumarin derived from psoralen, is often found in plants associated with phytophotodermatitis. Note that bergamot essential oil has a higher concentration of bergapten (3000–3600 mg/kg) than any other citrus-based essential oil. When bergamot essential oil is applied
Bergamot orange for grapefruit–drug interactions in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs. Used in cosmetics and perfume products, bergamot may cause skin irritation. In the past, psoralen extracted from bergamot oil has been used in tanning accelerators and sunscreens. These substances have been known to be photocarcinogenic since 1959, but they were only banned from sunscreens in 1995. These photocarcinogenic substances were banned years after they had caused many cases of malignant melanoma and deaths. As of 2017, clinical research conducted on bergamot oil has been of poor quality, with no conclusions possible