Macaque stump-tailed macaque within the "M. sinica" group. Prehistoric (fossil) species: Macaque The macaques ( or ) constitute a genus (Macaca) of Old World monkeys of the subfamily Cercopithecinae. The 23 species of macaques are distributed throughout Asia, North Africa and (in one instance) Gibraltar. Macaques are principally frugivorous, although their diet also includes seeds, leaves, flowers, and tree bark, and some, such as the crab-eating macaque, subsist on a diet of invertebrates and occasionally small vertebrates. Macaques are found in a variety of habitats throughout the Asian continent, and are extremely adaptable. All macaque social groups are arranged around dominant,
Rhesus macaque significance because the macaque is used as an experimental model of the human immune system. In humans, the preferentially expressed antigen of melanoma (PRAME) gene family is expanded. It is actively expressed in cancers, but normally is testis-specific, possibly involved in spermatogenesis. The PRAME family has 26 members on human chromosome 1. In the macaque, it has eight, and has been very simple and stable for millions of years. The PRAME family arose in translocations in the common mouse-primate ancestor 85 million years ago, and is expanded on mouse chromosome 4. DNA microarrays are used in macaque research. For example,