Collared titi causes them to give alarm peeps, probably because they must be especially alert to predators. A margay was detected alongside a dead collared titi during recent censuses on the Purité River in Colombia, although the monkey was not freshly killed. The local group was no longer observed after this. The collared titi is not considered to be endangered, but where there are many colonists this primate tends to disappear, due to deforestation. The species is commonly hunted and eaten by indigenous peoples or used as bait for hunting larger carnivores or for fishing; however, where there is plenty of forest
Collared titi meat the species is found commonly close to Indian settlements. The species is classified "Least Concern" (formerly LR) in the IUCN Red List. Actually the Colombian black-handed titi may be slightly endangered due to its presence in a zone of heavy colonization, but presently it is classified LC with the other subspecies. Fortunately the Colombian black-handed titi is found in La Paya National Park in Colombia, although the park itself is very vulnerable to surrounding colonization. The Lucifer titi is protected in Colombia by Amacayacu National Park and Cahuinarí National Park, while the black titi may be protected in Chiribiquete