Rhesus macaque Rhesus macaque The rhesus macaque ("Macaca mulatta") is one of the best-known species of Old World monkeys. It is listed as Least Concern in the IUCN Red List of Threatened Species in view of its wide distribution, presumed large population, and its tolerance of a broad range of habitats. Native to South, Central, and Southeast Asia, rhesus macaque have the widest geographic ranges of any nonhuman primate, occupying a great diversity of altitudes and a great variety of habitats, from grasslands to arid and forested areas, but also close to human settlements. The rhesus macaque is brown or grey in
Rhesus macaque The X chromosome has three times more rearrangements than other chromosomes. The macaque gained 1,358 genes by duplication. Triangulation of human, chimpanzee, and macaque sequences showed expansion of gene families in each species. The "PKFP" gene, important in sugar (fructose) metabolism, is expanded in macaques, possibly because of their high-fruit diet. So are genes for the olfactory receptor, cytochrome P450 (which degrades toxins), and CCL3L1-CCL4 (associated in humans with HIV susceptibility). Immune genes are expanded in macaques, relative to all four great ape species. The macaque genome has 33 major histocompatibility genes, three times those of human. This has clinical