Wisbech Ouse being a common Celtic word relating to water, and the name of a river that once flowed through the town. Alternatively, the first element may derive from the River Whissey which used to run to Wisbech or possibly ‘marshy-meadow valley or ridge’. OE Wisc or wisc + bece or baec. During the Iron Age, the area where Wisbech would develop lay in the west of the Brythonic Iceni tribe's territory. Icenian coins are known from both March and Wisbech. Like the rest of Cambridgeshire, Wisbech was part of the Kingdom of East Anglia after the Anglo-Saxon invasion. The first
Wisbech authentic references to Wisbech occur in a charter dated 664 granting the Abbey at Medehamstead (now Peterborough) land in Wisbech and in 1000, when Oswy and Leoflede, on the admission of their son Aelfwin as a monk, gave the vill to the monastery of Ely. In 1086, when Wisbech was held by the abbot, there may have been some 65 to 70 families, or about 300 to 350 persons, in Wisbech manor. However, Wisbech, which is the only one of the Marshland vills of the isle to be mentioned in the "Domesday Book", probably comprised the whole area from Tydd