Chemical element named mendelevium in honor of D.I. Mendeleev, the first to arrange the elements in a periodic manner. Most recently, the synthesis of element 118 (since named oganesson) was reported in October 2006, and the synthesis of element 117 (tennessine) was reported in April 2010. Ten materials familiar to various prehistoric cultures are now known to be chemical elements: Carbon, copper, gold, iron, lead, mercury, silver, sulfur, tin, and zinc. Three additional materials now accepted as elements, arsenic, antimony, and bismuth, were recognized as distinct substances prior to 1500 AD. Phosphorus, cobalt, and platinum were isolated before 1750. Most of the
CU-2010 and CU-2020 but they are 100,000 times better at inhibiting factor Xa and factor Xia. These inhibitory properties as well as their inhibition of plasma kallikrein and thrombin, reduces the production of thrombin and coagulation time. In vitro studies confirmed the fibrinolysis inhibition capacity of CU-2010 when present at concentrations between 100 and 1000 nM. The prolongation of coagulation (or prothrombin time, PT) occurs following either tissue factor or contact-phase stimulation and is dose-dependent. CU-2010 acts as an effective contact-phase inhibitor at antifibrinolytic concentrations. Further, when CU-2010 and CU-2020 are continuously infused, the greater inhibition of factors Xa and XIa compared to