Period 4 element be dangerous in large enough quantities due to its radioactivity. Nickel (Ni) is an element in period 4, between cobalt and copper. Nickel is rare in the Earth's crust, mainly due to the fact that it reacts with oxygen in the air, with most of the nickel on Earth coming from nickel iron meteorites. However, nickel is incredibly common in the Earth's core; along with iron it is one of the two main components. Nickel is an important component of stainless steel, and in many superalloys. Copper (Cu) is an element in period 4, between nickel and zinc. Copper is
CU-2010 and CU-2020 but they are 100,000 times better at inhibiting factor Xa and factor Xia. These inhibitory properties as well as their inhibition of plasma kallikrein and thrombin, reduces the production of thrombin and coagulation time. In vitro studies confirmed the fibrinolysis inhibition capacity of CU-2010 when present at concentrations between 100 and 1000 nM. The prolongation of coagulation (or prothrombin time, PT) occurs following either tissue factor or contact-phase stimulation and is dose-dependent. CU-2010 acts as an effective contact-phase inhibitor at antifibrinolytic concentrations. Further, when CU-2010 and CU-2020 are continuously infused, the greater inhibition of factors Xa and XIa compared to