Pneumatic artificial muscles Pneumatic artificial muscles Pneumatic artificial muscles (PAMs) are contractile or extensional devices operated by pressurized air filling a pneumatic bladder. In an approximation of human muscles, PAMs are usually grouped in pairs: one agonist and one antagonist. PAMs were first developed (under the name of "McKibben Artificial Muscles") in the 1950s for use in artificial limbs. The Bridgestone rubber company (Japan) commercialized the idea in the 1980s under the name of Rubbertuators. The retraction strength of the PAM is limited by the sum total strength of individual fibers in the woven shell. The exertion distance is limited by the tightness
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21