Group 11 element can also lead to the accumulation of these metals in body tissue; the results are the irreversible but apparently harmless pigmentation conditions known as chrysiasis and argyria respectively. Due to being short lived and radioactive, roentgenium has no biological use but it is likely extremely harmful due to its radioactivity. Group 11 element Group 11, by modern IUPAC numbering, is a group of chemical elements in the periodic table, consisting of copper (Cu), silver (Ag), and gold (Au). Roentgenium (Rg) is also placed in this group in the periodic table, although no chemical experiments have yet been carried out to
CU-2010 and CU-2020 a substrate, due to its peptide-like properties. After intravenous infusion, CU-2010 is quickly cleared as it has a half-life of about 20 minutes (in rats and dogs). Polymerization and covalent attachment of polymer chains of polyethylene glycol (PEG) or pegylation results in the formation of CU-2020, which has a longer half-life of 45 minutes. The advantage of the short half-life of CU-2010 is that it allows it to work in an “on-off” mode, hence being able to adapt to the haemostatic situation of the moment. CU-2010 and CU-2020 have the ability to inhibit plasmin to a similar extent as aprotinin,