Colonization of the outer Solar System is subject to only 0.01 rem a day. When NASA carried out a study called "HOPE" (Revolutionary Concepts for Human Outer Planet Exploration) regarding the future exploration of the Solar System, the target chosen was Callisto. It might be possible to build a surface base that would produce fuel for further exploration of the Solar System. The Keck Observatory announced in 2006 that the binary Jupiter trojan 617 Patroclus, and possibly many other Jupiter trojans, are likely composed of water ice, with a layer of dust. This suggests that mining water and other volatiles in this region and transporting them
Planet Nine and proposed a possible orbit for the planet. This hypothesis could also explain TNOs with orbits perpendicular to the inner planets and others with extreme inclinations, as well as the tilt of the Sun's axis. Planet Nine is hypothesized to follow a highly elliptical orbit around the Sun with a period lasting 10,000–20,000 years. The planet's semi-major axis is estimated to be , roughly 20 times the distance from Neptune to the Sun, and its inclination to the ecliptic, the plane of the Solar System, to be about . The high eccentricity of Planet Nine's orbit could bring it as