Electrode potential Electrode potential Electrode potential, "E", in chemistry or electrochemistry, according to a IUPAC definition, is the electromotive force of a cell built of two electrodes: The SHE is defined to have a potential of 0 V, so the signed cell potential from the above setup is SHE is cathode and electrode is anode Electrode potential appears at the interface between an electrode and electrolyte due to the transfer of charged species across the interface, specific adsorption of ions at the interface, and specific adsorption/orientation of polar molecules, including those of the solvent. Electrode potential is the electric potential on an
Chronic electrode implant that glial encapsulation, i.e. gliosis, insulates the electrode from nearby neurons, thereby hindering diffusion and increasing impedance, extends the distance between the electrode and its nearest target neurons, or creates an inhibitory environment for neurite extension, thus repelling regenerating neural processes away from recording sites"”. Either activated astrocytes or buildup of cellular debris from cell death around the electrode would act to insulate the recording sites from other, active neurons. Even very small increases in the separation between the electrode and local nerve population can insulate the electrode completely, as electrodes must be within 100 um to get a signal.