Rio Mayo titi this species to survive, their forests need to be protected to avoid overpopulation. Different conservation groups are working to help "P. oenanthe" survive. Neotropical Primate Conservation, Proyecto Mono Tocón and Amazónicos para la Amazonia are working in the more southern areas to protect the monkey. The Rio Mayo titi is a fairly inconspicuous creature, making observation and research difficult to obtain. Therefore, the traditional use of transect observation to monitor the monkey's population, is less effective. Instead, other methods of calculating the titi monkey's density in certain areas have been taken, such as research into the species-specific calls endemic to
Caquetá titi titi and white-tailed titi except that it does not have a white forehead bar, nor does it have the white hands and feet of the ornate titi. It also has a red beard. It has 22 chromosome pairs (not counting the sex chromosomes), with a diploid chromosome number of 2n=46. In the paper describing the species, the authors recommend that the species be classified as critically endangered by the International Union for Conservation of Nature (IUCN). According to the authors' estimate, the population size of the species may be fewer than 250 adult animals. It lives in forests fragmented by