Animal testing on non-human primates between the monkeys natural behaviors versus the behaviors expressed by the diazepam induced monkeys in thirteen different locations inside the maze. Scientist Barros and his colleagues created this model to allow the monkeys to roam a less confined environment and slightly eliminate outside factors that may induce stress. Many of the best-known allegations of abuse made by animal protection or animal rights groups against animal-testing facilities involve NHPs. The so-called "pit of despair" was used in experiments conducted on rhesus macaque monkeys during the 1970s by American comparative psychologist Harry Harlow at the University of Wisconsin–Madison.<ref name="Blum1994/95">Blum, Deborah. "The Monkey
Rhesus macaque Michael Katze of University of Washington, Seattle, infected macaques with 1918 and modern influenzas. The DNA microarray showed the macaque genomic response to human influenza on a cellular level in each tissue. Both viruses stimulated innate immune system inflammation, but the 1918 flu stimulated stronger and more persistent inflammation, causing extensive tissue damage, and it did not stimulate the interferon-1 pathway. The DNA response showed a transition from innate to adaptive immune response over seven days. The full sequence and annotation of the macaque genome is available on the Ensembl genome browser. Rhesus macaque The rhesus macaque ("Macaca mulatta") is