Chemical element named mendelevium in honor of D.I. Mendeleev, the first to arrange the elements in a periodic manner. Most recently, the synthesis of element 118 (since named oganesson) was reported in October 2006, and the synthesis of element 117 (tennessine) was reported in April 2010. Ten materials familiar to various prehistoric cultures are now known to be chemical elements: Carbon, copper, gold, iron, lead, mercury, silver, sulfur, tin, and zinc. Three additional materials now accepted as elements, arsenic, antimony, and bismuth, were recognized as distinct substances prior to 1500 AD. Phosphorus, cobalt, and platinum were isolated before 1750. Most of the
CU-2010 and CU-2020 that by aprotinin prevent early thrombosis, providing an anti-coagulatory effect in patients, and prolonging activated partial thromboplastin time (aPTT). Prolonged time for lysis further displays the anti-fibrinolytic characteristics of these drugs. Together, the anti-coagulatory and anti-fibrinolytic effects reduce the chance of thrombo-embolic complications. CU-2010 and CU-2020 possess anti inflammatory effects due to their inhibition on plasma–kallikrein. CU-2010 and CU-2020 reduce leukocyte-endothelial interaction, migration of leukocytes, adhesion molecules expression, rate of apoptosis, inflammatory genes expression (especially TNF-α) and protein synthesis, all events which normally occur after myocardial ischemia/reperfusion. These anti-inflammatory effects of the serine protease inhibitors result in a reduced amount