Japanese macaque Japanese macaque The Japanese macaque (; "Macaca fuscata"), also known as the snow monkey, is a terrestrial Old World monkey species that is native to Japan. They get their name "snow monkey" because they live in areas where snow covers the ground for months each year – no other nonhuman primate is more northern-living, nor lives in a colder climate. Individuals have brown-grey fur, red faces, and short tails. Two subspecies are known. In Japan, the species is known as Nihonzaru (ニホンザル, a combination of "Nihon" 日本 "Japan" + "saru" 猿 "monkey") to distinguish it from other primates, but the
Rhesus macaque significance because the macaque is used as an experimental model of the human immune system. In humans, the preferentially expressed antigen of melanoma (PRAME) gene family is expanded. It is actively expressed in cancers, but normally is testis-specific, possibly involved in spermatogenesis. The PRAME family has 26 members on human chromosome 1. In the macaque, it has eight, and has been very simple and stable for millions of years. The PRAME family arose in translocations in the common mouse-primate ancestor 85 million years ago, and is expanded on mouse chromosome 4. DNA microarrays are used in macaque research. For example,