Bergamot essential oil for a number of grapefruit–drug interactions. In one case study, a patient who consumed four liters of Earl Grey tea per day suffered paresthesias, fasciculations and muscle cramps. Bergamot essential oil Bergamot essential oil is a cold-pressed essential oil produced by cells inside the rind of a bergamot orange fruit. It is a common flavoring and top note in perfumes. The scent of bergamot essential oil is similar to a sweet light orange peel oil with a floral note. The "sfumatura" or slow-folding process was the traditional technique for manually extracting the bergamot oil. By more modern methods, the oil
Bergamot essential oil directly to the skin via a patch test, followed by exposure to ultraviolet light, a concentration-dependent phototoxic effect is observed. However, if the oil is twice rectified (and therefore bergapten-free), no phototoxic response is observed. The International Fragrance Association (IFRA) restricts the use of bergamot essential oil due to its phototoxic effects. Specifically, IFRA recommends that leave-on skin products be limited to 0.4% bergamot oil, which is more restrictive than any other citrus-based essential oil. Although generally recognized as safe for human consumption, bergamot essential oil contains a significant amount of bergamottin, one of two furanocoumarins believed to be responsible