Evolution of human colour vision opsins was increasing from 400 to 430. During this time, Ancestral Boreotherian had two long wave length opsins created by gene duplication, with one retaining the absolute max value of 560, equal to the ancestral value. This led to the creation of the modern human long wavelength sensitive, or red opsin. The other short wavelength sensitive opsin decreased its absolute max value to 530 and became the middle wavelength sensitive, or green-sensitive opsin. This occurred through mutations involving S180A, Y277F and T285A. The order that these mutations took place in the ancestral Boreotheria is currently not fully known. It is
Cherry eye defect in the retinaculum which is responsible for anchoring the gland to the periorbita. This defect causes the gland to prolapse and protrude from the eye as a red fleshy mass. Problems arise as sensitive tissue dries out and is subjected to external trauma Exposure of the tissue often results in secondary inflammation, swelling, or infection. If left untreated, this condition can lead to dry eye syndrome and other complications. Cherry eye is most common in young dogs, especially breeds such as Cavalier King Charles Spaniel, English Bulldog, Lhasa Apso, Shih Tzu, West Highland White Terrier, Pug, Bloodhound, American Cocker