Group 11 element Group 11 element Group 11, by modern IUPAC numbering, is a group of chemical elements in the periodic table, consisting of copper (Cu), silver (Ag), and gold (Au). Roentgenium (Rg) is also placed in this group in the periodic table, although no chemical experiments have yet been carried out to confirm that it behaves like the heavier homologue to gold. Group 11 is also known as the "coinage metals", due to their former usage. They were most likely the first three elements discovered. Copper, silver, and gold all occur naturally in elemental form. All the elements of the group except
CU-2010 and CU-2020 that by aprotinin prevent early thrombosis, providing an anti-coagulatory effect in patients, and prolonging activated partial thromboplastin time (aPTT). Prolonged time for lysis further displays the anti-fibrinolytic characteristics of these drugs. Together, the anti-coagulatory and anti-fibrinolytic effects reduce the chance of thrombo-embolic complications. CU-2010 and CU-2020 possess anti inflammatory effects due to their inhibition on plasma–kallikrein. CU-2010 and CU-2020 reduce leukocyte-endothelial interaction, migration of leukocytes, adhesion molecules expression, rate of apoptosis, inflammatory genes expression (especially TNF-α) and protein synthesis, all events which normally occur after myocardial ischemia/reperfusion. These anti-inflammatory effects of the serine protease inhibitors result in a reduced amount