Rio Mayo titi in deforestation is leading to the decrease in available living space for this titi monkey, forcing it to live in sympatry with another species of "Callicebus". Yet in some areas, such drastic deforestation has resulted in extremely high population density. The Rio Mayo titi is better adapted to moderately populated areas, thus overpopulation negatively impacts the species. The forests the Rio Mayo titi lives in are being destroyed for agricultural purposes, leaving little forest for the monkeys. They were only seen a few times and featured in museums until 2003 when more research was done on them. In order for
Collared titi meat the species is found commonly close to Indian settlements. The species is classified "Least Concern" (formerly LR) in the IUCN Red List. Actually the Colombian black-handed titi may be slightly endangered due to its presence in a zone of heavy colonization, but presently it is classified LC with the other subspecies. Fortunately the Colombian black-handed titi is found in La Paya National Park in Colombia, although the park itself is very vulnerable to surrounding colonization. The Lucifer titi is protected in Colombia by Amacayacu National Park and Cahuinarí National Park, while the black titi may be protected in Chiribiquete