Rio Mayo titi this species to survive, their forests need to be protected to avoid overpopulation. Different conservation groups are working to help "P. oenanthe" survive. Neotropical Primate Conservation, Proyecto Mono Tocón and Amazónicos para la Amazonia are working in the more southern areas to protect the monkey. The Rio Mayo titi is a fairly inconspicuous creature, making observation and research difficult to obtain. Therefore, the traditional use of transect observation to monitor the monkey's population, is less effective. Instead, other methods of calculating the titi monkey's density in certain areas have been taken, such as research into the species-specific calls endemic to
White-eared titi species within the genus "Plecturocebus". Although the exact position of species within the genus "Plecturocebus" in the "P. donacophilus" group with the Rio Beni titi ("P. modestus"), Rio Mayo titi ("P. oenanthe"), Ollala brothers' titi ("P. olallae"), and white-coated titi ("P. pallescens"). The white-coated titi has sometimes been considered a subspecies of the white-eared titi, but they are treated as separate species in the latest edition of Mammal Species of the World. The white-eared titi is a medium-sized primate with grey to orange pelage. The species does not exhibit sexual dimorphism; the male's head and body length averages while females