Haptic perception by metabolic, toxic and/or immunologic factors. Examples of medical conditions that can cause neuropathies are diabetes mellitus, chronic kidney disease, thyroid dysfunction (hyper- and hypothyroidism) as well as hepatitis, liver cirrhosis and alcohol dependency. Loss of the sense of touch is a catastrophic deficit that can impair walking and other skilled actions such as holding objects or using tools. Immersive environments can recreate the feeling of haptic interaction. Exoskeletal gloves such as the Exo-Skin Soft Haptic exoskeletal interface, developed at Drexel University, can be programmed to take a patient through a program of physical therapy exercises to retrain muscles and
Haptic technology flight simulators for pilot training. It is very critical to exert proper force magnitude to the user. It requires considering human force sensitivity. Haptic feedback is commonly used in arcade games, especially racing video games. In 1976, Sega's motorbike game "Moto-Cross", also known as "Fonz", was the first game to use haptic feedback which caused the handlebars to vibrate during a collision with another vehicle. Tatsumi's "TX-1" introduced force feedback to car driving games in 1983. The game "Earthshaker!" was the first pinball machine with haptic feedback in 1989. Simple haptic devices are common in the form of game controllers,