Electrode potential Potential of a cell assembled of two electrodes can be determined from the two individual electrode potentials using or, equivalently, This follows from the IUPAC definition of the electric potential difference of a galvanic cell, according to which the electric potential difference of a cell is the difference of the potentials of the electrodes on the right and the left of the galvanic cell. When Δ"V" is positive, then positive electrical charge flows through the cell from the left electrode (anode) to the right electrode (cathode). Electrode potential Electrode potential, "E", in chemistry or electrochemistry, according to a IUPAC definition,
Chronic electrode implant that glial encapsulation, i.e. gliosis, insulates the electrode from nearby neurons, thereby hindering diffusion and increasing impedance, extends the distance between the electrode and its nearest target neurons, or creates an inhibitory environment for neurite extension, thus repelling regenerating neural processes away from recording sites"”. Either activated astrocytes or buildup of cellular debris from cell death around the electrode would act to insulate the recording sites from other, active neurons. Even very small increases in the separation between the electrode and local nerve population can insulate the electrode completely, as electrodes must be within 100 um to get a signal.