Crookesite Crookesite Crookesite is a selenide mineral composed of copper and selenium with variable thallium and silver. Its chemical formula is reported either as Cu(Tl,Ag)Se or (Cu,Tl,Ag)Se. It is formed by precipitation from hydrothermal fluids, and contains by mass: 16.3% Tl, 47.3% Cu, 2.9% Ag, and 33.6% Se. Crookesite is an opaque, bluish grey to pink toned brown metallic mineral crystallizing in the tetragonal system. It has a Mohs hardness of 2.5 to 3 and a specific gravity of 6.9. It was discovered in 1866 in Skrikerum, Sweden and named for Sir William Crookes (1832–1919), the discoverer of the element thallium.
CU-2010 and CU-2020 but they are 100,000 times better at inhibiting factor Xa and factor Xia. These inhibitory properties as well as their inhibition of plasma kallikrein and thrombin, reduces the production of thrombin and coagulation time. In vitro studies confirmed the fibrinolysis inhibition capacity of CU-2010 when present at concentrations between 100 and 1000 nM. The prolongation of coagulation (or prothrombin time, PT) occurs following either tissue factor or contact-phase stimulation and is dose-dependent. CU-2010 acts as an effective contact-phase inhibitor at antifibrinolytic concentrations. Further, when CU-2010 and CU-2020 are continuously infused, the greater inhibition of factors Xa and XIa compared to