Wisbech Ouse being a common Celtic word relating to water, and the name of a river that once flowed through the town. Alternatively, the first element may derive from the River Whissey which used to run to Wisbech or possibly ‘marshy-meadow valley or ridge’. OE Wisc or wisc + bece or baec. During the Iron Age, the area where Wisbech would develop lay in the west of the Brythonic Iceni tribe's territory. Icenian coins are known from both March and Wisbech. Like the rest of Cambridgeshire, Wisbech was part of the Kingdom of East Anglia after the Anglo-Saxon invasion. The first
Wisbech Canal George III. Cap. 92) which was granted on 9 May 1794. This Act formed "The Wisbech Canal Company", which had powers to raise £14,000, with an option to raise an additional £6,000 if required. This was to be used to construct the canal which ran from a junction with the River Nene at Wisbech, to a junction with the Well Creek and the Old River Nene at Outwell. The Well Creek connects to the Great Ouse. In addition, the company had powers to maintain and improve the river from Outwell Church to Salter's Lode Sluice on the Old River Nene.