Macaque China reported in the journal "Cell" the creation of two crab-eating macaque monkey clones, named "Zhong Zhong" and "Hua Hua", using the complex DNA transfer method that produced "Dolly" the sheep, for the first time. As of 2005, the authors of "Mammal Species of the World" recognized the following species and species groups, aside from the white-cheeked macaque which was described in 2015: Later studies disputed some of the species groupings. For example, Li, "et al", based on DNA testing, do not recognize the "M. fascularis" group. Rather, they place the crab-eating macaque within the "M. mulatta" group and the
Rhesus macaque significance because the macaque is used as an experimental model of the human immune system. In humans, the preferentially expressed antigen of melanoma (PRAME) gene family is expanded. It is actively expressed in cancers, but normally is testis-specific, possibly involved in spermatogenesis. The PRAME family has 26 members on human chromosome 1. In the macaque, it has eight, and has been very simple and stable for millions of years. The PRAME family arose in translocations in the common mouse-primate ancestor 85 million years ago, and is expanded on mouse chromosome 4. DNA microarrays are used in macaque research. For example,