Electrode potential electrode component. In a cell, there is an electrode potential for the cathode and an electrode potential for the anode. The difference between the two electrode potentials equals the cell potential: The measured electrode potential may be either that at equilibrium on the working electrode ("reversible potential"), or a potential with a non-zero net reaction on the working electrode but zero net current ("corrosion potential", "mixed potential"), or a potential with a non-zero net current on the working electrode (like in galvanic corrosion or voltammetry). Reversible potentials can be sometimes converted to the standard electrode potential for a given electroactive
Chronic electrode implant that glial encapsulation, i.e. gliosis, insulates the electrode from nearby neurons, thereby hindering diffusion and increasing impedance, extends the distance between the electrode and its nearest target neurons, or creates an inhibitory environment for neurite extension, thus repelling regenerating neural processes away from recording sites"”. Either activated astrocytes or buildup of cellular debris from cell death around the electrode would act to insulate the recording sites from other, active neurons. Even very small increases in the separation between the electrode and local nerve population can insulate the electrode completely, as electrodes must be within 100 um to get a signal.