Period 4 element be dangerous in large enough quantities due to its radioactivity. Nickel (Ni) is an element in period 4, between cobalt and copper. Nickel is rare in the Earth's crust, mainly due to the fact that it reacts with oxygen in the air, with most of the nickel on Earth coming from nickel iron meteorites. However, nickel is incredibly common in the Earth's core; along with iron it is one of the two main components. Nickel is an important component of stainless steel, and in many superalloys. Copper (Cu) is an element in period 4, between nickel and zinc. Copper is
CU-2010 and CU-2020 that by aprotinin prevent early thrombosis, providing an anti-coagulatory effect in patients, and prolonging activated partial thromboplastin time (aPTT). Prolonged time for lysis further displays the anti-fibrinolytic characteristics of these drugs. Together, the anti-coagulatory and anti-fibrinolytic effects reduce the chance of thrombo-embolic complications. CU-2010 and CU-2020 possess anti inflammatory effects due to their inhibition on plasma–kallikrein. CU-2010 and CU-2020 reduce leukocyte-endothelial interaction, migration of leukocytes, adhesion molecules expression, rate of apoptosis, inflammatory genes expression (especially TNF-α) and protein synthesis, all events which normally occur after myocardial ischemia/reperfusion. These anti-inflammatory effects of the serine protease inhibitors result in a reduced amount