Chemical element of metals. Cu comes from Cuprum, Fe comes from Ferrum, Ag from Argentum. The symbols were not followed by a period (full stop) as with abbreviations. Later chemical elements were also assigned unique chemical symbols, based on the name of the element, but not necessarily in English. For example, sodium has the chemical symbol 'Na' after the Latin "natrium". The same applies to "W" (wolfram) for tungsten, "Fe" (ferrum) for iron, "Hg" (hydrargyrum) for mercury, "Sn" (stannum) for tin, "K" (kalium) for potassium, "Au" (aurum) for gold, "Ag" (argentum) for silver, "Pb" (plumbum) for lead, "Cu" (cuprum) for copper, and
CU-2010 and CU-2020 a substrate, due to its peptide-like properties. After intravenous infusion, CU-2010 is quickly cleared as it has a half-life of about 20 minutes (in rats and dogs). Polymerization and covalent attachment of polymer chains of polyethylene glycol (PEG) or pegylation results in the formation of CU-2020, which has a longer half-life of 45 minutes. The advantage of the short half-life of CU-2010 is that it allows it to work in an “on-off” mode, hence being able to adapt to the haemostatic situation of the moment. CU-2010 and CU-2020 have the ability to inhibit plasmin to a similar extent as aprotinin,