Collared titi causes them to give alarm peeps, probably because they must be especially alert to predators. A margay was detected alongside a dead collared titi during recent censuses on the Purité River in Colombia, although the monkey was not freshly killed. The local group was no longer observed after this. The collared titi is not considered to be endangered, but where there are many colonists this primate tends to disappear, due to deforestation. The species is commonly hunted and eaten by indigenous peoples or used as bait for hunting larger carnivores or for fishing; however, where there is plenty of forest
Coimbra Filho's titi preferred habitat for Coimbra Filho's titi consists of densely wooded areas, preferring the dense understory and lower canopy. However, it is able to survive in damaged or fragmented forests, which currently comprise a large portion of its range. This is due to a tolerance to highly disturbed areas, as well as the ability to subsist in areas composed primarily of young or second growth forests. While other species in "Callicebus" are native to many areas of South America from Colombia to Brazil, Peru and north Paraguay, Coimbra Filho's titi is found only in a very small area in the states