Rio Mayo titi in deforestation is leading to the decrease in available living space for this titi monkey, forcing it to live in sympatry with another species of "Callicebus". Yet in some areas, such drastic deforestation has resulted in extremely high population density. The Rio Mayo titi is better adapted to moderately populated areas, thus overpopulation negatively impacts the species. The forests the Rio Mayo titi lives in are being destroyed for agricultural purposes, leaving little forest for the monkeys. They were only seen a few times and featured in museums until 2003 when more research was done on them. In order for
Ornate titi daily activity lasts for around 11.5 hours, with feeding taking up around 2.7 hours. Their day is typically split into two feeding sessions, one in the morning and one in the evening, with a resting session at around midday. The last few hours of the day are generally spent feeding on leaves. The predominant and most important predators of all titis are raptors. Several species of raptor have been observed attacking a titi, including the Guianan crested eagle ("Morphnus guianensis") and the Ornate hawk-eagle ("Spizaetus ornatus"). Tufted capuchins ("Cebus apella") have also been observed killing and consuming an ornate titi.