Crookesite Crookesite Crookesite is a selenide mineral composed of copper and selenium with variable thallium and silver. Its chemical formula is reported either as Cu(Tl,Ag)Se or (Cu,Tl,Ag)Se. It is formed by precipitation from hydrothermal fluids, and contains by mass: 16.3% Tl, 47.3% Cu, 2.9% Ag, and 33.6% Se. Crookesite is an opaque, bluish grey to pink toned brown metallic mineral crystallizing in the tetragonal system. It has a Mohs hardness of 2.5 to 3 and a specific gravity of 6.9. It was discovered in 1866 in Skrikerum, Sweden and named for Sir William Crookes (1832–1919), the discoverer of the element thallium.
CU-2010 and CU-2020 CU-2010 and CU-2020 CU-2010 and CU-2020 are synthetic compounds that act as serine protease inhibitors. These were developed in 2010 to replace the use of aprotinin during and after cardiac surgery, including surgeries with cardiopulmonary bypass which cause blood loss and hemorrhagic complications. CU-2010 and CU-2020 were developed to avoid many issues associated with the use of aprotinin, including the risk of an allergic reaction and infection. Since the isolation of aprotinin is expensive, a drug with a simpler synthesis was desired. CU-2010 has a molecular weight of 700 Da and binds to the active site of serine proteases, like