Philippine long-tailed macaque height of 40–50 cm (16–20 in). It is the size of a domestic cat. Male macaques weigh 4–8 kg, but females only attain 3–4 kg. The Philippine long-tailed macaque is found in all major Philippine island groups (Luzon, Visayas, Mindanao). However, though assessed Near Threatened, it is actually in serious retreat or already extinct in much of its original range. For instance, in Olongapo in Zambales Province (western central Luzon), where a patch of old-growth forest remains, the monkeys have found some refuge; however, they are often road killed, accidentally electrocuted by live wires, and sometimes stoned. Philippine long-tailed macaque
Rhesus macaque significance because the macaque is used as an experimental model of the human immune system. In humans, the preferentially expressed antigen of melanoma (PRAME) gene family is expanded. It is actively expressed in cancers, but normally is testis-specific, possibly involved in spermatogenesis. The PRAME family has 26 members on human chromosome 1. In the macaque, it has eight, and has been very simple and stable for millions of years. The PRAME family arose in translocations in the common mouse-primate ancestor 85 million years ago, and is expanded on mouse chromosome 4. DNA microarrays are used in macaque research. For example,