Crookesite Crookesite Crookesite is a selenide mineral composed of copper and selenium with variable thallium and silver. Its chemical formula is reported either as Cu(Tl,Ag)Se or (Cu,Tl,Ag)Se. It is formed by precipitation from hydrothermal fluids, and contains by mass: 16.3% Tl, 47.3% Cu, 2.9% Ag, and 33.6% Se. Crookesite is an opaque, bluish grey to pink toned brown metallic mineral crystallizing in the tetragonal system. It has a Mohs hardness of 2.5 to 3 and a specific gravity of 6.9. It was discovered in 1866 in Skrikerum, Sweden and named for Sir William Crookes (1832–1919), the discoverer of the element thallium.
CU-2010 and CU-2020 that by aprotinin prevent early thrombosis, providing an anti-coagulatory effect in patients, and prolonging activated partial thromboplastin time (aPTT). Prolonged time for lysis further displays the anti-fibrinolytic characteristics of these drugs. Together, the anti-coagulatory and anti-fibrinolytic effects reduce the chance of thrombo-embolic complications. CU-2010 and CU-2020 possess anti inflammatory effects due to their inhibition on plasma–kallikrein. CU-2010 and CU-2020 reduce leukocyte-endothelial interaction, migration of leukocytes, adhesion molecules expression, rate of apoptosis, inflammatory genes expression (especially TNF-α) and protein synthesis, all events which normally occur after myocardial ischemia/reperfusion. These anti-inflammatory effects of the serine protease inhibitors result in a reduced amount