Rio Mayo titi this species to survive, their forests need to be protected to avoid overpopulation. Different conservation groups are working to help "P. oenanthe" survive. Neotropical Primate Conservation, Proyecto Mono Tocón and Amazónicos para la Amazonia are working in the more southern areas to protect the monkey. The Rio Mayo titi is a fairly inconspicuous creature, making observation and research difficult to obtain. Therefore, the traditional use of transect observation to monitor the monkey's population, is less effective. Instead, other methods of calculating the titi monkey's density in certain areas have been taken, such as research into the species-specific calls endemic to
Ornate titi daily activity lasts for around 11.5 hours, with feeding taking up around 2.7 hours. Their day is typically split into two feeding sessions, one in the morning and one in the evening, with a resting session at around midday. The last few hours of the day are generally spent feeding on leaves. The predominant and most important predators of all titis are raptors. Several species of raptor have been observed attacking a titi, including the Guianan crested eagle ("Morphnus guianensis") and the Ornate hawk-eagle ("Spizaetus ornatus"). Tufted capuchins ("Cebus apella") have also been observed killing and consuming an ornate titi.