Collared titi causes them to give alarm peeps, probably because they must be especially alert to predators. A margay was detected alongside a dead collared titi during recent censuses on the Purité River in Colombia, although the monkey was not freshly killed. The local group was no longer observed after this. The collared titi is not considered to be endangered, but where there are many colonists this primate tends to disappear, due to deforestation. The species is commonly hunted and eaten by indigenous peoples or used as bait for hunting larger carnivores or for fishing; however, where there is plenty of forest
Ornate titi daily activity lasts for around 11.5 hours, with feeding taking up around 2.7 hours. Their day is typically split into two feeding sessions, one in the morning and one in the evening, with a resting session at around midday. The last few hours of the day are generally spent feeding on leaves. The predominant and most important predators of all titis are raptors. Several species of raptor have been observed attacking a titi, including the Guianan crested eagle ("Morphnus guianensis") and the Ornate hawk-eagle ("Spizaetus ornatus"). Tufted capuchins ("Cebus apella") have also been observed killing and consuming an ornate titi.