Calyx of Held nervous system has allowed for direct research within a mammalian model and the large size increases the ease of electrophysiological recording. For these reasons it has been popular in understanding transmitter release. Specifically, the calyx of Held is used because of: Calyx of Held The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named by Hans Held in his 1893 article "Die centrale Gehörleitung" because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the
Calyx of Held and processing of the cochlear nucleus. Math1, another transcription factor, is necessary for the appearance of VCN neurons in the cochlear extramural stream as well as the neurons of the superior olivary complex. NB-2 also assists in the advancement of the formation of the calyx of Held, as well as contributing to the upkeep of the contralateral MNTB. The combined effects of these three molecules with one another illustrate the fact that there are many families of proteins involved in proper signaling and formation of the calyx. Additionally, Eph proteins are integral for further auditory circuit system development after initial