Australian Stock Saddle much deeper seat, higher cantle, and knee pads in the front to create a very secure saddle for riders who ride in rough conditions or spend long hours on a horse. The saddle is kept on with a girth attached to billets under the flaps, similar to those on a dressage saddle. A surcingle passing over the seat of the saddle is also used to provide additional safety. The rear of the saddle is sometimes secured by a crupper. A breastcollar is sometimes added. A saddle blanket or numnah is used under the saddle to absorb sweat and to protect
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics