Calyx of Held Calyx of Held The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named by Hans Held in his 1893 article "Die centrale Gehörleitung" because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the trapezoid body (MNTB), where they synapse via these calyces on MNTB principal cells. These principal cells then project to the ipsilateral lateral superior olive (LSO), where they inhibit postsynaptic neurons and provide a basis for interaural level detection (ILD), required for
History of botany books, known as herbals showed that botany was still a part of medicine, as it had been for most of ancient history. Authors of herbals were often curators of university gardens, and most herbals were derivative compilations of classic texts, especially "De Materia Medica". However, the need for accurate and detailed plant descriptions meant that some herbals were more botanical than medicinal. German Otto Brunfels's (1464–1534) "Herbarum Vivae Icones" (1530) contained descriptions of about 47 species new to science combined with accurate illustrations. His fellow countryman Hieronymus Bock's (1498–1554) "Kreutterbuch" of 1539 described plants he found in nearby woods and