Horse collar of the Oseberg ship burial). The problem with a breastcollar harness was that the actual shafts of the cart, chariot, or other vehicle are attached to a surcingle around the barrel of the horse. The breastplate primarily kept the surcingle from slipping back, not as the primary pushing object. This results in the horse literally pulling the load, a less efficient use of the animal. The modern breastcollar has traces which transfer the pull directly from the breastcollar, but a horse collar still is more effective for pulling heavy loads. After the breastcollar harness, the next and final evolutionary stage
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics