Surcingle behind the withers. When used with a saddle, the surcingle runs over the seat near the pommel. A surcingle is also used over the top of certain types of pack saddle and pack to keep the pack bags and swag in place. A surcingle is usually used with a pad, and fit to the horse's back as carefully as a saddle would be. It is tightened enough to prevent slipping, more when used with a saddle and rider, less when used for ground training. Surcingle A surcingle is a strap made of leather or leather-like synthetic materials such as nylon
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics