Surcingle Surcingle A surcingle is a strap made of leather or leather-like synthetic materials such as nylon or neoprene, sometimes with elastic, that fastens around the horse's girth. A surcingle may be used for ground training, some types of in-hand exhibition, and over a saddle or horse pack to stabilize the rider's weight. It also is a primary component of a horse harness. A basic surcingle is unpadded, attaches around the horse by means of buckles or rings, and has no other hardware. A training surcingle, sometimes called a "roller," has many extra rings attached, running from the ribcage up to
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics