Calyx of Held nervous system has allowed for direct research within a mammalian model and the large size increases the ease of electrophysiological recording. For these reasons it has been popular in understanding transmitter release. Specifically, the calyx of Held is used because of: Calyx of Held The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named by Hans Held in his 1893 article "Die centrale Gehörleitung" because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the
Discodermia calyx species, among others with similar toxins, became increasingly studied and important in medicine, particularly relating to chemotherapy. In a later study, scientist concluded that the calyculin A, from "D. calyx," also blocks calcium influx by blocking non-selective ion channels in the cell. Later research looked into "D. calyx" as a species to look at the natural mechanisms that can be used to regulate the toxicity of calyculin A. Scientist found regulation through phosphorylation and dephosphorylation. These among other studies focus on regulation of the toxin as a characteristic of the sponge Discodermia Calyx because of its implications in the fight