Carotid artery dissection Carotid artery dissection Carotid artery dissection is a separation of the layers of the artery wall supplying oxygen-bearing blood to the head and brain and is the most common cause of stroke in young adults. (In vascular medicine, dissection is a blister-like de-lamination between the outer and inner walls of a blood vessel, generally originating with a partial leak in the inner lining.) The signs and symptoms of carotid artery dissection may be divided into ischemic and non-ischemic categories: "Non-ischemic signs and symptoms" "Ischemic signs and symptoms" The causes of internal carotid artery dissection can be broadly categorised into two
Carotid body may involve mitochondrial oxygen sensors and the haem-containing cytochromes that undergo reversible one-electron reduction during oxidative-phosphorylation. Haem reversibly binds O with an affinity similar to that of the carotid body, suggesting that haem containing proteins may have a role in O, potentially this could be one of the complexes involved in oxidative-phosphorylation. This leads to increases in reactive oxygen species and rises in intracellular Ca. However, whether hypoxia leads to an increase or decrease in reactive oxygen species is unknown. The role of reactive oxygen species in hypoxia sensing is also under question. The oxygen dependent enzyme haem-oxidase has also