Surcingle longe lines, requires the use of a surcingle to thread the longe lines through the rings. Compared to a saddle, a surcingle allows more precise adjustment of side reins due to the placement of additional rings. While a saddle only provides one height to attach the rings (the girth buckles), and can be uneven or at the wrong position, a training surcingle places rings at more appropriate locations for ground work. Many surcingle designs allow the side reins to be attached at several different heights along the sides of the horse. When used without a saddle, a surcingle sits just
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics