Girth (tack) Girth (tack) A girth, sometimes called a cinch (Western riding), is a piece of equipment used to keep the saddle in place on a horse or other animal. It passes under the barrel of the equine, usually attached to the saddle on both sides by two or three leather straps called billets. Girths are used on Australian and English saddles, while western saddles and many pack saddles have a cinch, which is fastened to the saddle by a single wide leather strap on each side, called a latigo. Although a girth is often enough to keep a well-fitting saddle in
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics