Sistine Chapel ceiling and the relatively conservative concept of the relationship between Eve and her Creator adheres closely to Jacopo's design. Other panels on the ceiling, most particularly the iconic "Creation of Adam" show "... unprecedented invention". The ceiling of the Sistine Chapel was to have a profound effect upon other artists, even before it was completed. Vasari, in his Life of Raphael, tells us that Bramante, who had the keys to the chapel, let Raphael in to examine the paintings in Michelangelo's absence. On seeing Michelangelo's prophets, Raphael went back to the picture of the Prophet Isaiah that he was painting on
Restoration of the Sistine Chapel frescoes have been predicted by previous restorers. One of the major dangers to the frescoes is automotive exhaust, and they are also vulnerable to the effects of the crowds of tourists that pass through the chapel every day, bringing with them heat, humidity, dust and bacteria (the latter of which can biodegrade paints and pigments). The clean plaster surfaces are more in danger from these destructive elements than they were when they were covered with a layer of smoky wax. Previously, the Sistine Chapel's only ventilation was from its windows in the upper level of the walls. To prevent exhaust fumes