West Virginia per year, with 1,400 of those statistically attributed to deaths from heart, respiratory and kidney disease from living in an Appalachian coal county. In 2015, McDowell County had the highest rate of drug-induced deaths of any county in the United States, with a rate of 141 deaths per 100,000 people. Four of the five US counties with the highest rates of drug-induced deaths are located in West Virginia (McDowell, Wyoming, Cabell and Raleigh Counties). West Virginia's capital and seat of government is the city of Charleston, located in the southwest area of the state. The West Virginia Legislature is bicameral.
West Virginia Route 45 West Virginia Route 45 West Virginia Route 45 (WV 45) is a state highway in the U.S. state of West Virginia. The state highway runs from the Virginia state line near Glengary east to WV 230 and WV 480 in Shepherdstown. WV 45 connects the communities of Glengary and Arden in southwestern Berkeley County with the county seat of Martinsburg. The state highway also connects Shepherdstown in northern Jefferson County with Martinsburg, where the highway meets Interstate 81 (I-81), U.S. Route 11 (US 11), and WV 9. WV 45 begins at the Virginia state line in the southwestern corner of