Calyx of Held nervous system has allowed for direct research within a mammalian model and the large size increases the ease of electrophysiological recording. For these reasons it has been popular in understanding transmitter release. Specifically, the calyx of Held is used because of: Calyx of Held The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named by Hans Held in his 1893 article "Die centrale Gehörleitung" because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the
Calyx of Held embryonic calyx formation. One characteristic that distinguishes Eph proteins and their receptors from other signaling systems is their ability to transmit information bidirectionally. Forward and reverse signaling in VCN and MNTB cells is essential for the proper number and formation of VCN and ipsilateral MNTB projections in the calyx. Eph proteins also ensure that while axons pass through the ipsilateral MNTB, branching and final termination of these projections only occur in the contralateral MNTB, possibly because the proteins are only targeted towards specific regions on the axons. Overall, there are two ultrastructural changes that occur in the calyx of Held.