Girth (tack) often used in addition to a regular leather girth. Made of leather or nylon with an elastic insert (for racing), the overgirth completely encircles the horse around belly and the saddle's seat. It is used by stockmen, eventers, polo players, in flat racing, and by steeplechase jockeys to provide more security in holding the saddle in place. Some girths (those used on jumpers and eventers) have a belly guard (or stud guard), to protect the belly from being stabbed by horseshoe studs as the animal tucks his legs up underneath him over a tall obstacle. The traditional western cinch was
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics