Internal carotid plexus carotid plexus communicates with the trigeminal ganglion, the abducent nerve, and the pterygopalatine ganglion (also named sphenopalatine); it distributes filaments to the wall of the internal carotid artery, and also communicates with the tympanic branch of the glossopharyngeal nerve. Internal carotid plexus The internal carotid plexus (internal carotid plexus) is situated on the lateral side of the internal carotid artery, and in the plexus there occasionally exists a small gangliform swelling, the "carotid ganglion", on the under surface of the artery. Postganglionic sympathetic fibres ascend from the superior cervical ganglion, along the walls of the internal carotid artery, to enter
Carotid body been put forward as a hypoxia sensor. In normoxia, haem-oxygenase generates carbon monoxide (CO), CO activates the large conductance calcium-activated potassium channel, BK. Falls in CO that occur as a consequence of hypoxia would lead to closure of this potassium channel and this would lead to membrane depolarisation and consequence activation of the carotid body. A role for the "energy sensor" AMP-activated protein kinase (AMPK) has also been proposed in hypoxia sensing. This enzyme is activated during times of net energy usage and metabolic stress, including hypoxia. AMPK has a number of targets and it appears that, in the carotid