Calyx of Held nervous system has allowed for direct research within a mammalian model and the large size increases the ease of electrophysiological recording. For these reasons it has been popular in understanding transmitter release. Specifically, the calyx of Held is used because of: Calyx of Held The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named by Hans Held in his 1893 article "Die centrale Gehörleitung" because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the
Botany Candollean system reflected his ideas of the progression of morphological complexity and the later classification by Bentham and Hooker, which was influential until the mid-19th century, was influenced by Candolle's approach. Darwin's publication of the "Origin of Species" in 1859 and his concept of common descent required modifications to the Candollean system to reflect evolutionary relationships as distinct from mere morphological similarity. Botany was greatly stimulated by the appearance of the first "modern" textbook, Matthias Schleiden's "", published in English in 1849 as "Principles of Scientific Botany". Schleiden was a microscopist and an early plant anatomist who co-founded the cell