Saddle in various other Indo-European languages, including the Latin "sella". In addition to the above basic components, some saddles also include: There is evidence, though disputed, that humans first began riding the horse not long after domestication, possibly as early as 4000 BC. The earliest known saddle-like equipment were fringed cloths or pads used by Assyrian cavalry around 700 BC. These were held on with a girth or surcingle that included breast straps and cruppers. From the earliest depictions, saddles became status symbols. To show off an individual's wealth and status, embellishments were added to saddles, including elaborate sewing and leather
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics