Branch of glossopharyngeal nerve to carotid sinus help maintain a more consistent blood pressure) and from chemoreceptors in the carotid body (mainly monitoring blood gas PaO2 and PaCO2 levels). Hering's nerve responds to both increases and decreases in blood pressure while the baroreceptors in the aortic arch respond only to increases in blood pressure . Branch of glossopharyngeal nerve to carotid sinus The branch of glossopharyngeal nerve to the carotid sinus (Hering's nerve) is a small nerve in the neck, that innervates the carotid sinus and the carotid body. It is a branch of the glossopharyngeal nerve that runs downwards, anterior to the internal carotid artery. It
Carotid body been put forward as a hypoxia sensor. In normoxia, haem-oxygenase generates carbon monoxide (CO), CO activates the large conductance calcium-activated potassium channel, BK. Falls in CO that occur as a consequence of hypoxia would lead to closure of this potassium channel and this would lead to membrane depolarisation and consequence activation of the carotid body. A role for the "energy sensor" AMP-activated protein kinase (AMPK) has also been proposed in hypoxia sensing. This enzyme is activated during times of net energy usage and metabolic stress, including hypoxia. AMPK has a number of targets and it appears that, in the carotid