Presidency of James Monroe knowledge of the northwest region of the Louisiana Purchase. The expedition suffered several setbacks, but the efforts of scientists such as Edwin James advanced U.S. knowledge of the flora and fauna of the region. The federal government had taken control of the Yazoo lands from Georgia in the Compact of 1802; as part of that agreement, President Jefferson promised to remove Native Americans from the region. Georgians pressed Monroe to remove the remaining Native Americans to regions west of the Mississippi River, but the Native Americans rejected the Monroe administration's offers to purchase their land. As Monroe was unwilling to
James Monroe principles. The Quids tried to enlist Monroe in their cause. The plan was to run Monroe for president in the 1808 election in cooperation with the Federalist Party, which had a strong base in New England. John Randolph of Roanoke led the Quid effort to stop Jefferson's choice of Madison. The regular Democratic-Republicans overcame the Quids in the nominating caucus, kept control of the party in Virginia, and protected Madison's base. Monroe did not publicly criticize Jefferson or Madison during Madison's campaign against Federalist Charles Cotesworth Pinckney, and refused to support Madison. Madison defeated Pinckney by a large margin, carrying