Sistine Chapel ceiling and the relatively conservative concept of the relationship between Eve and her Creator adheres closely to Jacopo's design. Other panels on the ceiling, most particularly the iconic "Creation of Adam" show "... unprecedented invention". The ceiling of the Sistine Chapel was to have a profound effect upon other artists, even before it was completed. Vasari, in his Life of Raphael, tells us that Bramante, who had the keys to the chapel, let Raphael in to examine the paintings in Michelangelo's absence. On seeing Michelangelo's prophets, Raphael went back to the picture of the Prophet Isaiah that he was painting on
The Birth of Venus Politian speaks of Zephyr causing flowers to bloom, and spreading their scent over the land, which probably explains the roses he blows along with him in the painting. Having a large standing female nude as the central focus was unprecedented in post-classical Western painting, and certainly drew on the classical sculptures which were coming to light in this period, especially in Rome, where Botticelli had spent 1481–82 working on the walls of the Sistine Chapel. The pose of Botticelli's "Venus" follows the Venus Pudica ("Venus of Modesty") type from classical antiquity, where the hands are held to cover the breasts