Carotid canal Carotid canal The carotid canal is the passageway in the temporal bone through which the internal carotid artery enters the middle cranial fossa from the neck. The canal starts on the inferior surface of the temporal bone at the external opening of the carotid canal (also referred to as the carotid foramen). The canal ascends at first superiorly, and then, making a bend, runs anteromedially. The canal's internal opening is near the foramen lacerum, above which the internal carotid artery passes on its way anteriorly to the cavernous sinus. The carotid canal allows the internal carotid artery to pass into
Carotid body may involve mitochondrial oxygen sensors and the haem-containing cytochromes that undergo reversible one-electron reduction during oxidative-phosphorylation. Haem reversibly binds O with an affinity similar to that of the carotid body, suggesting that haem containing proteins may have a role in O, potentially this could be one of the complexes involved in oxidative-phosphorylation. This leads to increases in reactive oxygen species and rises in intracellular Ca. However, whether hypoxia leads to an increase or decrease in reactive oxygen species is unknown. The role of reactive oxygen species in hypoxia sensing is also under question. The oxygen dependent enzyme haem-oxidase has also