Carotid body A decrease in oxygen partial pressure, an increase in carbon dioxide partial pressure, and a decrease in arterial pH can all cause depolarization of the cell membrane, and they affect this by blocking potassium currents. This reduction in the membrane potential opens voltage-gated calcium channels, which causes a rise in intracellular calcium concentration. This causes exocytosis of vesicles containing a variety of neurotransmitters, including acetylcholine, noradrenaline, dopamine, adenosine, ATP, substance P, and met-enkephalin. These act on receptors on the afferent nerve fibres which lie in apposition to the glomus cell to cause an action potential. The feedback from the carotid
History of beliefs about the human body much on discourse about bodies, rather than on material bodies themselves. Drawing on Mikhail Bakhtin's 1965 "Rabelais and His World", they promoted a more materially orientated direction in the history of the body. The Ebers Papyrus is an Egyptian medical text and is the oldest known record of the human body, dating back to 3000 BC. The Ebers Papyrus describes the body by physical examination and what can be felt. Clinical investigations such as the Pulse, percussion of the body, the recognition of diseased or disordered states. “If thou examinst a swelling of the covering of his belly’s horns above