Calyx of Held nervous system has allowed for direct research within a mammalian model and the large size increases the ease of electrophysiological recording. For these reasons it has been popular in understanding transmitter release. Specifically, the calyx of Held is used because of: Calyx of Held The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named by Hans Held in his 1893 article "Die centrale Gehörleitung" because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the
Calyx of Held The first is that in the second week of development, myelination of the VCN axons in the MNTB increases. This prominent growth in myelin corresponds to the chronological development of the signaling circuit and adaptation of the calyx. The second ultrastructural change involves the principal neurons of the MNTBs, whose cell bodies and nuclei increase in surface area due to enlargement. This is a direct result of individual, larger postsynaptic densities breaking up into smaller, multiple densities. Potassium channels are vital in conducting the presynaptic action potential. The calyx contains several types of potassium channels, each differing in location and