Sistine Chapel ceiling picture is crowded with figures and separate incidents as the various individuals who have been attacked by snakes struggle and die or turn toward the icon that will save them. This is the most Mannerist of Michelangelo's earlier compositions at the Sistine Chapel, picking up the theme of human distress begun in the "Great Flood" scene and carrying it forward into the torment of lost souls in the "Last Judgement", which was later painted below. Between the large pendentives that support the vault are windows, six on each side of the chapel. There were two more windows in each end
The Birth of Venus Politian speaks of Zephyr causing flowers to bloom, and spreading their scent over the land, which probably explains the roses he blows along with him in the painting. Having a large standing female nude as the central focus was unprecedented in post-classical Western painting, and certainly drew on the classical sculptures which were coming to light in this period, especially in Rome, where Botticelli had spent 1481–82 working on the walls of the Sistine Chapel. The pose of Botticelli's "Venus" follows the Venus Pudica ("Venus of Modesty") type from classical antiquity, where the hands are held to cover the breasts