Internal carotid artery mainly of historical significance. The segments of the internal carotid artery are as follows: The internal carotid artery is a terminal branch of the common carotid artery; it arises around the level of the fourth cervical vertebra when the common carotid bifurcates into this artery and its more superficial counterpart, the external carotid artery. The cervical segment, or C1, or cervical part of the internal carotid, extends from the carotid bifurcation until it enters the carotid canal in the skull anterior to the jugular foramen. At its origin, the internal carotid artery is somewhat dilated. This part of the artery
Carotid body been put forward as a hypoxia sensor. In normoxia, haem-oxygenase generates carbon monoxide (CO), CO activates the large conductance calcium-activated potassium channel, BK. Falls in CO that occur as a consequence of hypoxia would lead to closure of this potassium channel and this would lead to membrane depolarisation and consequence activation of the carotid body. A role for the "energy sensor" AMP-activated protein kinase (AMPK) has also been proposed in hypoxia sensing. This enzyme is activated during times of net energy usage and metabolic stress, including hypoxia. AMPK has a number of targets and it appears that, in the carotid