Presidency of James Monroe knowledge of the northwest region of the Louisiana Purchase. The expedition suffered several setbacks, but the efforts of scientists such as Edwin James advanced U.S. knowledge of the flora and fauna of the region. The federal government had taken control of the Yazoo lands from Georgia in the Compact of 1802; as part of that agreement, President Jefferson promised to remove Native Americans from the region. Georgians pressed Monroe to remove the remaining Native Americans to regions west of the Mississippi River, but the Native Americans rejected the Monroe administration's offers to purchase their land. As Monroe was unwilling to
Presidency of James Monroe Monroe hoped that the appointment of Adams would encourage the defection of more Federalists. Monroe offered the position of Secretary of War to Henry Clay of Kentucky, but Clay was only willing to serve in the cabinet as Secretary of State. Monroe's decision to appoint Adams to the latter position alienated Clay, and Clay would oppose many of the administration's policies. After General Andrew Jackson and Governor Isaac Shelby declined appointment as Secretary of War, Monroe turned to South Carolina Congressman John C. Calhoun, leaving the cabinet without a prominent Westerner. In late 1817, Rush was appointed as the ambassador