Bitting rig rig." It is the use of additional reins such as the overcheck, or the use of leverage to place the horse's head in a set position that turns a classic surcingle into a bitting rig. Both a bitting rig and a classic surcingle with side reins are intended only to be used while longeing a horse. They are not to be used on a horse that is standing in a stall (though this is a very common type of misuse), nor are they used while riding. However, the surcingle and side reins are used as safety tools in the sport
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics