Saddle Saddle The saddle is a supportive structure for a rider or other load, fastened to an animal's back by a girth. The most common type is the equestrian saddle designed for a horse. However, specialized saddles have been created for oxen, camels and other creatures. It is not known precisely when riders first began to use some sort of padding or protection, but a blanket attached by some form of surcingle or girth was probably the first "saddle", followed later by more elaborate padded designs. The solid saddle tree was a later invention, and though early stirrup designs predated the
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics