Horses in warfare of today's English saddle. Both the Scythians and Assyrians used pads with added felt attached with a surcingle or girth around the horse's barrel for increased security and comfort. Xenophon mentioned the use of a padded cloth on cavalry mounts as early as the 4th century BC. The saddle with a solid framework, or "tree", provided a bearing surface to protect the horse from the weight of the rider, but was not widespread until the 2nd century AD. However, it made a critical difference, as horses could carry more weight when distributed across a solid saddle tree. A solid tree,
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics