Calyx of Held nervous system has allowed for direct research within a mammalian model and the large size increases the ease of electrophysiological recording. For these reasons it has been popular in understanding transmitter release. Specifically, the calyx of Held is used because of: Calyx of Held The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named by Hans Held in his 1893 article "Die centrale Gehörleitung" because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the
Calyx of Held sensitivity. Both low-threshold K channels and high-threshold delayed rectifier-type K channels are present in presynaptic neurons. There are four low-threshold K channels present: K1.1, K1.2, K1.3, and K7.5. K1.1 and K1.2 are located in the transition zone between the axon and the terminal, while K1.3 K7.5 are located in the calyx. There is a calcium activated potassium channel expressed in the calyx, however this type of channel does not contribute to neurotransmitter release. Within the span of one week, mice subjects (P7 to P14) showed that the density of the K1 and K3 low threshold channels increases, which in turn