Bronc riding toward the rigging handle, spurring at each jump in rhythm with the motion of the horse. Bareback bronc riding began to develop as a professional rodeo sporting event around 1900. The riding equipment used during that era varied. In some cases, the rider simply held onto the horse's mane, called a mane-hold. Others held a loose or twisted rope tied around the horse's girth, and other methods involved using multiple handhold leather riggings based on a surcingle. In the early 1920s, when the old rodeo rules allowing two handed riding were being phased out and replaced with the newer rule
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics