Presidency of James Monroe knowledge of the northwest region of the Louisiana Purchase. The expedition suffered several setbacks, but the efforts of scientists such as Edwin James advanced U.S. knowledge of the flora and fauna of the region. The federal government had taken control of the Yazoo lands from Georgia in the Compact of 1802; as part of that agreement, President Jefferson promised to remove Native Americans from the region. Georgians pressed Monroe to remove the remaining Native Americans to regions west of the Mississippi River, but the Native Americans rejected the Monroe administration's offers to purchase their land. As Monroe was unwilling to
Alexander W. Monroe 1905, at his home near Romney. Monroe was survived by his second wife Margaret and their four children. Monroe is interred with his wife Margaret at Indian Mound Cemetery in Romney. In 1852, Monroe married his first wife, Sarah A. French, daughter of John and Eleanor French. Monroe and his wife Sarah had one son, James W. Monroe. Following Sarah's death, Monroe married his second wife, Margaret Ellen Pugh, daughter of Benjamin and Sarah Pugh, on November 21, 1866. Monroe and Margaret had at least four children: Alexander W. Monroe Alexander W. Monroe (December 29, 1817 – March 16, 1905)