Carotid endarterectomy open. In several clinical trials, the 30-day incidence of heart attack, stroke, or death was significantly higher with stenting than with endarterectomy (9.6% vs. 3.9%). The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) funded by the National Institutes of Health (NIH) reported that the results of stents and endarterectomy were comparable. However, the European International Carotid Stenting Study (ICSS) found that stents had almost double the rate of complications. The aim of CEA is to prevent the adverse sequelae of carotid artery stenosis secondary to atherosclerotic disease, i.e. ischemic stroke. As with any prophylactic operation, careful evaluation of the relative
Carotid body central chemoreceptors in the medulla oblongata that are primarily sensitive to changes in pH and P (a decrease in pH and an increase in P). The carotid body chemoreceptors are also sensitive to pH and P, but only secondarily. More specifically, the sensitivity of carotid body chemoreceptors to decreased P is greater when pH is decreased and P is increased. The output of the carotid bodies is low at an oxygen partial pressure above about 100mmHg (13,3 kPa) (at normal physiological pH), but below 60mmHg the activity of the type I (glomus) cells increases rapidly due to a decrease in