Surcingle the withers area. It usually has padding to relieve pressure on the horse's spine. A variation of this design is used for equestrian vaulting. Many trainers first teach a young horse to accept girth pressure by strapping on a surcingle before a saddle and girth. The surcingle is commonly used for longeing, often as a base from which to attach training equipment such as side reins, overcheck, lauffer reins (sliding side reins), or chambons. A surcingle is also important in long lining or ground driving, as it provides rings for the long reins to run through. Double longeing, using two
Organ-on-a-chip it can facilitate cross-species extrapolation. Used in conjunction with PBPK models, the devices permit an estimation of effective concentrations that can be used for studies with animal models or predict the human response. In the development of multicompartment devices, representations of the human body such as those in used PBPK models can be used to guide the device design with regard to the arrangement of chambers and fluidic channel connections to augment the drug development process, resulting in increased success in clinical trials. Organ-on-a-chip An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics