Sistine Chapel ceiling and the relatively conservative concept of the relationship between Eve and her Creator adheres closely to Jacopo's design. Other panels on the ceiling, most particularly the iconic "Creation of Adam" show "... unprecedented invention". The ceiling of the Sistine Chapel was to have a profound effect upon other artists, even before it was completed. Vasari, in his Life of Raphael, tells us that Bramante, who had the keys to the chapel, let Raphael in to examine the paintings in Michelangelo's absence. On seeing Michelangelo's prophets, Raphael went back to the picture of the Prophet Isaiah that he was painting on
Sistine Chapel layer of animal glue and "lamp black", all of the wax, and all of the overpainted areas were contamination of one sort or another: smoke deposits, earlier restoration attempts, and painted definition by later restorers in an attempt to enliven the appearance of the work. Based on this decision, according to Arguimbau's critical reading of the restoration data that have been provided, the chemists of the restoration team decided upon a solvent that would effectively strip the ceiling down to its paint-impregnated plaster. After treatment, only that which was painted "buon fresco" would remain. The only reproduction of the Sistine