Carotid canal Carotid canal The carotid canal is the passageway in the temporal bone through which the internal carotid artery enters the middle cranial fossa from the neck. The canal starts on the inferior surface of the temporal bone at the external opening of the carotid canal (also referred to as the carotid foramen). The canal ascends at first superiorly, and then, making a bend, runs anteromedially. The canal's internal opening is near the foramen lacerum, above which the internal carotid artery passes on its way anteriorly to the cavernous sinus. The carotid canal allows the internal carotid artery to pass into
Carotid body acid-base transporters (e.g. Na-H) which raise intracellular pH, and activates transporters (e.g. Cl-HCO) which decrease it. Changes in proton concentration caused by acidosis (or the opposite from alkalosis) inside the cell stimulates the same pathways involved in P sensing. Another mechanism is through oxygen sensitive potassium channels. A drop in dissolved oxygen lead to closing of these channels which results in depolarization. This leads to release of the neurotransmitter dopamine in the glossopharyngeal and vagus afferente to the vasomotor area. The type I (glomus) cells in the carotid (and aortic bodies) are derived from neuroectoderm and are thus electrically excitable.