Carotid canal Carotid canal The carotid canal is the passageway in the temporal bone through which the internal carotid artery enters the middle cranial fossa from the neck. The canal starts on the inferior surface of the temporal bone at the external opening of the carotid canal (also referred to as the carotid foramen). The canal ascends at first superiorly, and then, making a bend, runs anteromedially. The canal's internal opening is near the foramen lacerum, above which the internal carotid artery passes on its way anteriorly to the cavernous sinus. The carotid canal allows the internal carotid artery to pass into
Carotid body been put forward as a hypoxia sensor. In normoxia, haem-oxygenase generates carbon monoxide (CO), CO activates the large conductance calcium-activated potassium channel, BK. Falls in CO that occur as a consequence of hypoxia would lead to closure of this potassium channel and this would lead to membrane depolarisation and consequence activation of the carotid body. A role for the "energy sensor" AMP-activated protein kinase (AMPK) has also been proposed in hypoxia sensing. This enzyme is activated during times of net energy usage and metabolic stress, including hypoxia. AMPK has a number of targets and it appears that, in the carotid