FNB Stadium is home to Kaizer Chiefs Football Club. It is also the preferred venue for the Soweto derby football matches - the country's biggest sporting showpiece - involving Soweto based Premier Soccer League clubs, Kaizer Chiefs and Orlando Pirates. It was also the traditional home of the Iwisa Maize Meal Spectacular and later, the Telkom Charity Cup, which were charity soccer season openers in South African football from 1990 to 2006, before it was closed for renovations. The Charity Cup then returned in 2010. The stadium was re-opened when it hosted the 2010 Nedbank Cup final between Bidvest Wits and Amazulu.
Kaizer Chiefs F.C. Pirates, a fellow Soweto team which Chiefs founder Kaizer Motaung played for in his early playing career. Famous players who donned the black and gold jersey in the past include former national team captains Neil Tovey, Lucas Radebe and also Patrick Ntsoelengoe, Gary Bailey, "Shoes Mosheu", Shaun Bartlett, Steve Komphela, Siyabonga Nomvete and Doctor Khumalo. Chiefs were banned by the Confederation of African Football (CAF) from competing in African club competitions until 2009 after their abrupt withdrawal from the 2005 CAF Confederation Cup. This was the second time in four years that Chiefs had been penalized by CAF for refusal