Tool (band) intentions differently: "Tool is exactly what it sounds like: It's a big dick. It's a wrench. ... we are ... your tool; use us as a catalyst in your process of finding out whatever it is you need to find out, or whatever it is you're trying to achieve." After almost two years of practicing and performing locally in the Los Angeles area, the band was approached by record companies, and eventually signed a record deal with Zoo Entertainment. In March 1992, Zoo released the band's first effort, "Opiate". Described by the band as "slam and bang" heavy music and
Transposons as a genetic tool The recent discovery of the 'mariner transposon' (from the reconstruction of the original sequence from many 'dead' versions in the human genome) has allowed many new experiments, mariner has well conserved homologues across a wide range of species and is a very versatile tool. Transposons as a genetic tool Transposons are semi-parasitic DNA sequences which can replicate and spread through the host's genome. They can be harnessed as a genetic tool for analysis of gene and protein function. The use of transposons is well-developed in "Drosophila" (in which P elements are most commonly used) and in Thale cress ("Arabidopsis thaliana")