Stringhalt outbreaks, distinct seasonal pattern and the ability of affected horses to recover spontaneously. This condition is characterised by the sudden exaggerated flexion of either one or both hocks. This form of stringhalt most commonly occurs in the summer and autumn while horses are out on pasture. Epidemics of Australian stringhalt are usually witnessed during drought or abnormally dry conditions. The long digital extensor muscle (usually in the hind limb) is the muscle that appears to be the most affected by this condition. The most severe muscle lesions have been found within the long and lateral digital extensors and lateral deep
Congenital disorder of glycosylation Congenital disorder of glycosylation A congenital disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. Congenital disorders of glycosylation are sometimes known as CDG syndromes. They often cause serious, sometimes fatal, malfunction of several different organ systems (especially the nervous system, muscles, and intestines) in affected infants. The most common sub-type is PMM2-CDG (formally known as CDG-Ia) where the genetic defect leads to the loss of phosphomannomutase 2 (PMM2), the enzyme responsible for the conversion of mannose-6-phosphate