Pneumonia exposure to cigarettes or air pollution, malnutrition, and poverty. The use of acid-suppressing medications — such as proton-pump inhibitors or H2 blockers — is associated with an increased risk of pneumonia. Approximately 10% of people who require mechanical ventilation develop ventilator associated pneumonia, and people with gastric feeding tube have an increased risk of developing of aspiration pneumonia. For people with specific variants of FER gene, the risk of death is reduced in sepsis caused by pneumonia. However, for those with TLR6 variants, the risk of getting Legionnaires' disease is increased. Bacteria are the most-common cause of community-acquired pneumonia (CAP),
Epidemiology of pneumonia case fatality rate in the UK is around 5–10%. In the United States, community-acquired pneumonia affects 5.6 million people per year, and ranks 6th among leading causes of death. In 2009, there were approximately 1.86 million emergency department encounters for pneumonia in the United States. In 2011, pneumonia was the second-most common reason for hospitalization in the U.S., with approximately 1.1 million stays—a rate of 36 stays per 10,000 population. Pneumonia was one of the top ten most expensive conditions seen during inpatient hospitalizations in the U.S. in 2011, with an aggregate cost of nearly $10.6 billion for 1.1 million