Stringhalt Stringhalt Stringhalt is a sudden flexion of one or both hind legs in the horse, most easily seen while the horse is walking or trotting. It is most evident when the horse is backing up slowly, turning on the affected leg, or suddenly frightened. It can involve one or both hind legs of the horse. It is a spasmodic contraction of the lateral extensor tendons of the hind legs. There are four forms of stringhalt: Treatment varies. Australian stringhalt was described and differentiated from classical stringhalt in 1884. Australian stringhalt is differentiated from classical stringhalt by the severity, occurrence of
Congenital disorder of glycosylation Congenital disorder of glycosylation A congenital disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. Congenital disorders of glycosylation are sometimes known as CDG syndromes. They often cause serious, sometimes fatal, malfunction of several different organ systems (especially the nervous system, muscles, and intestines) in affected infants. The most common sub-type is PMM2-CDG (formally known as CDG-Ia) where the genetic defect leads to the loss of phosphomannomutase 2 (PMM2), the enzyme responsible for the conversion of mannose-6-phosphate