Stringhalt to three years. Horses may be affected so severely that euthanasia is necessary. It is unknown how long it takes for clinical signs to develop after the exposure to the cause of the condition. The majority of horses affected by stringhalt are dependent upon pasture for nutrition. Removal of the horse from its original paddock containing low-quality pasture, weeds and native grasses, along with dietary control, was the most common and successful treatment. Lateral digital extensor tenectomy has also been used as a treatment by veterinarians with a success rate of just over 50%. Phenytoin has been used in the
Congenital disorder of glycosylation Congenital disorder of glycosylation A congenital disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. Congenital disorders of glycosylation are sometimes known as CDG syndromes. They often cause serious, sometimes fatal, malfunction of several different organ systems (especially the nervous system, muscles, and intestines) in affected infants. The most common sub-type is PMM2-CDG (formally known as CDG-Ia) where the genetic defect leads to the loss of phosphomannomutase 2 (PMM2), the enzyme responsible for the conversion of mannose-6-phosphate