Stringhalt management of Australian stringhalt. Two weeks after treatment with phenytoin, significant improvement was observed in the gait abnormality of horses affected with Australian stringhalt at the trot and canter, but no significant improvement was observed at the walk or while turning. The most common plant species that have been found and identified in pastures where affected horses were located include: flatweed ("Hypochaeris radicata"), sheep's sorrel ("Rumex acetosella") and couch grass ("Elymus repens"). The type of nerve damage sustained in horses with Australian stringhalt suggests a mould toxin (mycotoxin) or a fungal 'poison' found in the soils may be a cause
Congenital disorder of glycosylation Congenital disorder of glycosylation A congenital disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. Congenital disorders of glycosylation are sometimes known as CDG syndromes. They often cause serious, sometimes fatal, malfunction of several different organ systems (especially the nervous system, muscles, and intestines) in affected infants. The most common sub-type is PMM2-CDG (formally known as CDG-Ia) where the genetic defect leads to the loss of phosphomannomutase 2 (PMM2), the enzyme responsible for the conversion of mannose-6-phosphate