New York (state) States, while Midtown Manhattan is the largest central business district in the nation. Silicon Alley, centered in New York City, has evolved into a metonym for the sphere encompassing the New York City metropolitan region's high technology and entrepreneurship ecosystem; in 2015, Silicon Alley generated over US$7.3 billion in venture capital investment. High tech industries including digital media, biotechnology, software development, game design, and other fields in information technology are growing, bolstered by New York City's position at the terminus of several transatlantic fiber optic trunk lines, its intellectual capital, as well as its growing outdoor wireless connectivity. In December
Science and technology in Israel voice-mail company; and Mercury Interactive, which measures software performance. A high concentration of high-tech industries in the coastal plain of Israel has led to the nickname Silicon Wadi (lit: "Silicon Valley"). Both Israeli and international companies are based there. Intel and Microsoft built their first overseas research and development centers in Israel, and other high-tech multi-national corporations, such as IBM, Cisco Systems, and Motorola, have opened facilities in the country. Intel developed its dual-core Core Duo processor at its Israel Development Center in Haifa. More than 3,850 start-ups have been established in Israel, making it second only to the US