Silkie the "SHH" gene, called the ZPA Regulatory Sequence (ZRS). This causes ectopic "SHH" expression in the anterior of the developing limb bud, leading to increased tissue growth and digits. While the feet of the Silkie display polydactyly, the wings have the standard tridactyly (three digit) arrangement. The Japanese Silkie initially develops additional digits in the wing as an embryo, but these are lost prior to hatching. The genetic cause behind Silkie polydactyly differs from those that cause polydactyly in the Dorking chicken breed, which is due to ectopic "FGF4" expression in the AER, with ectopic "SHH" a secondary effect. The
What a Pushkin, what a son of a bitch! What a Pushkin, what a son of a bitch! "What a Pushkin, what a son of a bitch!" (; sometimes separated by exclamation mark instead of comma) is a catchphrase and winged word from Alexander Pushkin's correspondence with one of his friends, poet Pyotr Vyazemsky. The phrase commonly expresses a joy after finishing one's work and appears particularly in several Russian literary works. In a letter dated circa November 7 or beginning of October, 1825 Pushkin, celebrating his finished drama "Boris Godunov" wrote to Vyazemsky: That was preceded by what Pushkin wrote to Vyazemsky on July 13 of the same