The Prime Minister (novel) The Prime Minister (novel) The Prime Minister is a novel by Anthony Trollope, first published in 1876. It is the fifth of the "Palliser" series of novels. When neither the Whigs nor the Tories are able to form a government on their own, a fragile compromise coalition government is formed, with Plantagenet Palliser, the wealthy and hard-working Duke of Omnium, installed as Prime Minister of the United Kingdom. The Duchess, formerly Lady Glencora Palliser, attempts to support her husband by hosting lavish parties at Gatherum Castle in Barsetshire, the family's largest country house, barely used until now. Palliser, initially unsure
Diseases and epidemics of the 19th century and Robert Koch's discovery of micro-organisms as the cause of disease transmission. Thus throughout the majority of the 19th century, there was only the most basic, common sense understanding of the causes, amelioration and treatment of epidemic disease. The late 19th century was the beginning of widespread use of vaccines. The cholera bacterium was isolated in 1854 by Italian anatomist Filippo Pacini, and a vaccine, the first to immunize humans against a bacterial disease, was developed by Spanish physician Jaume Ferran i Clua in 1885, and by Russian-Jewish bacteriologist Waldemar Haffkine in July 1892. Antibiotic drugs did not appear until