Stringhalt to three years. Horses may be affected so severely that euthanasia is necessary. It is unknown how long it takes for clinical signs to develop after the exposure to the cause of the condition. The majority of horses affected by stringhalt are dependent upon pasture for nutrition. Removal of the horse from its original paddock containing low-quality pasture, weeds and native grasses, along with dietary control, was the most common and successful treatment. Lateral digital extensor tenectomy has also been used as a treatment by veterinarians with a success rate of just over 50%. Phenytoin has been used in the
Animal model of schizophrenia a growth factor which is crucial to the development of the nervous system, and to neurotransmission and formation of synapses in adults. NRG1 and the gene for the receptor to which neuregulin 1 binds, ERBB4, have been tested as possible animal models of schizophrenia. While mice which have two copies of (are homozygous for) a knocked out version of NRG1 do not survive, viable animal models have been developed using heterozygous or partial knockout. One such mouse model is the heterozygous removal of the EGF-like domain on neuregulin 1, these models are called Nrg1(ΔEGF) mice. Nrg1(ΔEGF) mice have been shown