Honey bee one queen bee, a fertile female; seasonally up to a few thousand drone bees, or fertile males; and tens of thousands of sterile female worker bees. Details vary among the different species of honey bees, but common features include: In cold climates, honey bees stop flying when the temperature drops below about and crowd into the central area of the hive to form a "winter cluster". The worker bees huddle around the queen bee at the center of the cluster, shivering to keep the center between at the start of winter (during the broodless period) and once the queen resumes
Honey bee as apitoxin, carries several active components, the most abundant of which is melittin, and the most biologically active are enzymes, particularly phospholipase A2. Bee venom is under laboratory and clinical research for its potential properties and uses in reducing risks for adverse events from bee venom therapy, rheumatoid arthritis, and use as an immunotherapy for protection against allergies from insect stings. Bee venom products are marketed in many countries, but, as of 2018, there are no approved clinical uses for these products which carry various warnings for potential allergic reactions. With an increased number of honey bees in a specific