Chromatic scale common conception of the chromatic scale before the 13th century was the Pythagorean chromatic scale (). Due to a different tuning technique, the twelve semitones in this scale have two slightly different sizes. Thus, the scale is not perfectly symmetric. Many other tuning systems, developed in the ensuing centuries, share a similar asymmetry. In Pythagorean tuning (3-limit just intonation) the chromatic scale is tuned as follows, with sharps higher than their enharmonic flats: These are 17-EDO Pythagorean tuning approximations. In 5-limit just intonation the chromatic scale, Ptolemy's intense chromatic scale, is as follows, with flats higher than their enharmonic sharps,
Diatonic and chromatic tuned. Among this latter class, some instruments, such as the piano, are always tuned to a chromatic scale, and can be played in any key, while others are restricted to a diatonic scale, and therefore to a particular key. Some instruments, such as the harmonica, harp, and glockenspiel, are available in both diatonic and chromatic versions (although it is possible to play chromatic notes on a diatonic harmonica, they require extended embouchure techniques, and some chromatic notes are only usable by advanced players). Because "diatonic scale" is itself ambiguous, distinguishing intervals is also ambiguous. For example, the interval B–E (a