Silkie the "SHH" gene, called the ZPA Regulatory Sequence (ZRS). This causes ectopic "SHH" expression in the anterior of the developing limb bud, leading to increased tissue growth and digits. While the feet of the Silkie display polydactyly, the wings have the standard tridactyly (three digit) arrangement. The Japanese Silkie initially develops additional digits in the wing as an embryo, but these are lost prior to hatching. The genetic cause behind Silkie polydactyly differs from those that cause polydactyly in the Dorking chicken breed, which is due to ectopic "FGF4" expression in the AER, with ectopic "SHH" a secondary effect. The
What Is a Nation? French citizen has to have forgotten the massacre of Saint Bartholomew, or the massacre that took place in the South in the thirteenth century. While many nations, such as France, begin with a feudal regime such as a monarchy, others, such as the United States and Switzerland, are formed by acts of consensual aggregation. France and many others, however, survived their feudal roots while maintaining their identity. Renan inquires what is the organizing principle? It can't be race, because France is "Celt, Iberian, German...The most noble countries, England, France and Italy, are the ones where the blood is most mixed."