Stringhalt Stringhalt Stringhalt is a sudden flexion of one or both hind legs in the horse, most easily seen while the horse is walking or trotting. It is most evident when the horse is backing up slowly, turning on the affected leg, or suddenly frightened. It can involve one or both hind legs of the horse. It is a spasmodic contraction of the lateral extensor tendons of the hind legs. There are four forms of stringhalt: Treatment varies. Australian stringhalt was described and differentiated from classical stringhalt in 1884. Australian stringhalt is differentiated from classical stringhalt by the severity, occurrence of
Animal model of schizophrenia a growth factor which is crucial to the development of the nervous system, and to neurotransmission and formation of synapses in adults. NRG1 and the gene for the receptor to which neuregulin 1 binds, ERBB4, have been tested as possible animal models of schizophrenia. While mice which have two copies of (are homozygous for) a knocked out version of NRG1 do not survive, viable animal models have been developed using heterozygous or partial knockout. One such mouse model is the heterozygous removal of the EGF-like domain on neuregulin 1, these models are called Nrg1(ΔEGF) mice. Nrg1(ΔEGF) mice have been shown