Pneumonia exposure to cigarettes or air pollution, malnutrition, and poverty. The use of acid-suppressing medications — such as proton-pump inhibitors or H2 blockers — is associated with an increased risk of pneumonia. Approximately 10% of people who require mechanical ventilation develop ventilator associated pneumonia, and people with gastric feeding tube have an increased risk of developing of aspiration pneumonia. For people with specific variants of FER gene, the risk of death is reduced in sepsis caused by pneumonia. However, for those with TLR6 variants, the risk of getting Legionnaires' disease is increased. Bacteria are the most-common cause of community-acquired pneumonia (CAP),
Hospital-acquired pneumonia sputum samples and intensive care patients, in whom these bacteria were commonly found. In one observational study, empirical antibiotic treatment that was not according to international treatment guidelines was an independent predictor of worse outcome among HCAP patients. Guidelines from Canada suggest that HCAP can be treated like community-acquired pneumonia with antibiotics targeting Streptococcus pneumoniae, based on studies using blood cultures in different settings which have not found high rates of MRSA or Pseudomonas. Besides prompt antibiotic treatment, supportive measure for organ failure (such as cardiac decompensation) are also important. Another consideration goes to hospital referral; although more severe pneumonia