Stringhalt digital flexor. The location of neuromuscular lesions in Australian stringhalt may be explained by the susceptibility of longer, larger myelinated nerve fibres to injury. Regenerating nerve fibres with disproportionately thin myelin sheaths are more common in the proximal parts of affected nerves in horses with Australian stringhalt. Distal axonopathy occurs most severely in the longest nerve in the horse. The cause for this distal axonopathy remains unknown. Horses affected with this condition rarely recover without surgical intervention, although there have been some instances where horses have recovered without treatment. The recovery time in affected horses can range from three months
Animal models of depression Animal models of depression Animal models of depression are research tools used to investigate depression and action of antidepressants as a simulation to investigate the symptomatology and pathophysiology of depressive illness or used to screen novel antidepressants. Major depressive disorder, also called "clinical depression" or often simply "depression", is a common, long-lasting and diverse psychiatric syndrome that significantly affects a person's thoughts, behavior, feelings and sense of well-being. Symptoms include low mood and aversion to activity. Depressed people may also feel sad, anxious, empty, hopeless, worried, helpless, worthless, guilty, irritable, hurt, or restless. They may lose interest in activities that