Stringhalt digital flexor. The location of neuromuscular lesions in Australian stringhalt may be explained by the susceptibility of longer, larger myelinated nerve fibres to injury. Regenerating nerve fibres with disproportionately thin myelin sheaths are more common in the proximal parts of affected nerves in horses with Australian stringhalt. Distal axonopathy occurs most severely in the longest nerve in the horse. The cause for this distal axonopathy remains unknown. Horses affected with this condition rarely recover without surgical intervention, although there have been some instances where horses have recovered without treatment. The recovery time in affected horses can range from three months
Central nervous system fatigue Central nervous system fatigue Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system (CNS; including the brain and spinal cord) which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function. In healthy individuals, central fatigue can occur from prolonged exercise and is associated with neurochemical changes in the brain, primarily involving serotonin (5-HT), noradrenaline, and dopamine. Central fatigue plays an important role in endurance sports and also highlights the importance of proper nutrition