Stringhalt outbreaks, distinct seasonal pattern and the ability of affected horses to recover spontaneously. This condition is characterised by the sudden exaggerated flexion of either one or both hocks. This form of stringhalt most commonly occurs in the summer and autumn while horses are out on pasture. Epidemics of Australian stringhalt are usually witnessed during drought or abnormally dry conditions. The long digital extensor muscle (usually in the hind limb) is the muscle that appears to be the most affected by this condition. The most severe muscle lesions have been found within the long and lateral digital extensors and lateral deep
Animal model of schizophrenia a growth factor which is crucial to the development of the nervous system, and to neurotransmission and formation of synapses in adults. NRG1 and the gene for the receptor to which neuregulin 1 binds, ERBB4, have been tested as possible animal models of schizophrenia. While mice which have two copies of (are homozygous for) a knocked out version of NRG1 do not survive, viable animal models have been developed using heterozygous or partial knockout. One such mouse model is the heterozygous removal of the EGF-like domain on neuregulin 1, these models are called Nrg1(ΔEGF) mice. Nrg1(ΔEGF) mice have been shown