Silkie the "SHH" gene, called the ZPA Regulatory Sequence (ZRS). This causes ectopic "SHH" expression in the anterior of the developing limb bud, leading to increased tissue growth and digits. While the feet of the Silkie display polydactyly, the wings have the standard tridactyly (three digit) arrangement. The Japanese Silkie initially develops additional digits in the wing as an embryo, but these are lost prior to hatching. The genetic cause behind Silkie polydactyly differs from those that cause polydactyly in the Dorking chicken breed, which is due to ectopic "FGF4" expression in the AER, with ectopic "SHH" a secondary effect. The
What a piece of work is a man What a piece of work is a man "What a piece of work is man!" is a phrase within a soliloquy by Prince Hamlet in William Shakespeare's play of the same name. Hamlet is reflecting, at first admiringly, and then despairingly, on the human condition. The soliloquy, spoken in the play by Prince Hamlet to Rosencrantz and Guildenstern in Act II, Scene 2, follows in its entirety. Rather than appearing in blank verse, the typical mode of composition of Shakespeare's plays, the speech appears in straight prose: Hamlet is saying that although humans may appear to think and act "nobly"