Quinine London. It remained the antimalarial drug of choice until the 1940s, when other drugs took over. The form of quinine most effective in treating malaria was found by Charles Marie de La Condamine in 1737. In 1820, French researchers Pierre Joseph Pelletier and Joseph Bienaimé Caventou first isolated quinine from the bark of a tree in the genus "Cinchona" - probably "Cinchona officinalis" - and subsequently named the substance. The name was derived from the original Quechua (Inca) word for the cinchona tree bark, "quina" or "quina-quina", which means "bark of bark" or "holy bark". Prior to 1820, the bark
Naturally aspirated engine Naturally aspirated engine A naturally aspirated engine is an internal combustion engine in which oxygen intake depends solely on atmospheric pressure and does not rely on forced induction through a turbocharger or a supercharger. Many sports cars specifically use naturally aspirated engines to avoid turbo lag. In a naturally aspirated engine, air for combustion (diesel cycle in a diesel engine or specific types of Otto cycle in petrol engines—namely petrol direct injection), or an air/fuel mixture (traditional Otto cycle petrol engines)—is drawn into the engine’s cylinders by atmospheric pressure acting against a partial vacuum that occurs as the piston travels