Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
We Are All on Drugs was eventually released that way on early printings of the album, and on published sheet music. It was replaced on future printings (as well as on the CD single) with "I want to reach a higher plane/ where things will never be the same." An edited version of the song for MTV "We Are All in Love," changed "on drugs" to "in love" in the chorus. Patrick Wilson suggested having the edit be "We Are All on Hugs," which Cuomo thought was too "quirky." Brian Bell suggested the "in love" edit. Despite this edit the headline "WE ARE ALL ON