Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Masquerade in Blood the second and last for drummer Atomic Steif, since the former was arrested in 1996 for possession of drugs, while the latter left the band for personal reasons. "Masquerade in Blood" continues in the same crossover thrash vein as their previous studio effort "Get What You Deserve" (which was released in the previous year), however it is most notable for introducing a new groove metal style, with "overwhelming" death metal being present on select songs. AllMusic's Eduardo Rivadavia gave the album two stars out of five, noting it as being "something of a return to form" for the band. However,