Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
Drugs in Cambodia among the arrested. They were allegedly caught in possession of nearly half a kilo of methamphetamines and cocaine. The men potentially face life sentences if they are to be convicted. These recent developments and arrests only further emphasizes that Cambodia is cracking down on the drug trade which exists in the country. According to secretary-general of the National Authority to Combat Drugs they emphasized that ‘There will be further raids. We are cracking down hard on people who provide illegal drugs.’ On April 10, 2009, four drug traders and traffickers, including two Cambodian nationals were prosecuted and arrested. The four