Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
Fire in the Blood (2013 film) such fora as the United Nations headquarters in New York City and Vienna, the European Parliament in Brussels, the World Health Assembly and UNAIDS headquarters in Geneva, along with dedicated screenings for lawmakers in Washington and New Delhi, and one hosted by the Indian Ministry of External Affairs (MEA) for ambassadors and consuls accredited to India. Fire in the Blood (2013 film) Fire in the Blood is a 2013 documentary film by Dylan Mohan Gray depicting the intentional obstruction of access to low-cost antiretroviral drugs used in the treatment of HIV/AIDS to people in Africa and other parts the global