Consumer Reports Best Buy Drugs category; and cost less on average than other drugs in the category. Several of the Best Buys have been chosen because of their superior effectiveness or safety profile even though they may cost more. The project publishes Best Buy Drugs drug reports, the first three such reports covered Statins to reduce high cholesterol, heartburn drugs, and NSAIDs commonly used to treat arthritis. The project covers over 20 conditions and the most widely used drugs. The reports are published in web versions, and two-page PDF summaries in English and Spanish. More than half of all prescription drugs cause adverse effects—some serious
Discovery and development of statins Asp and the O5 hydroxyl group of the hydroxyglutartic acid component of the statins. Van der Waals interactions are formed between the hydrophobic side chains of the enzyme, which involve the Leu, Val, Leu, Ala and Leu and the statins. Type 2 statins form polar interaction between the fluorine atom on the fluorophenyl group and the guanidinium group of Arg. In addition to these interactions atorvastatin and rosuvastatin also form unique hydrogen bonds between Ser residue and either a carbonyl oxygen atom (atorvastatin) or a sulfone oxygen atom (rosuvastatin). A unique polar interaction between the Arg side chain and the