Quinine the Quechua, who are indigenous to Peru, Bolivia and Ecuador, to halt shivering due to low temperatures. The Quechuas would mix the ground bark of cinchona trees with sweetened water to offset the bark's bitter taste, thus producing tonic water. The Jesuits were the first to bring cinchona to Europe. The Spanish were aware of the medicinal properties of cinchona bark by the 1570s or earlier: Nicolás Monardes (1571) and Juan Fragoso (1572) both described a tree that was subsequently identified as the cinchona tree and whose bark was used to produce a drink to treat diarrhea. Quinine has been
Cinchona viceroy in Lima. While the veracity of the claims and the details are highly debated leaving it best treated as a legend, the curative properties were known even earlier. The history of the plant, their extracts, and the cures are however highly confused and controversial. Suggestions that the plant went by the native name of Quina Quina which yielded Quina bark have been questioned. Other fever cures from South America were known as Jesuit's Bark and Jesuit's Powder in Europe earlier but although they have been traced to "Cinchona", there is evidence of materials being derived from other species such