Cinchona in the year 1851. Mr. [Thaddäus] Haenke mentioned the existence of cinchona bark on his visit to Yuracares in 1796". (Source: Exploration of the Valley of the Amazon, by Lieut. Lardner Gibbon, USN. Vol.II, Ch.6, pp. 146-47.) The cultivation of cinchona led from the 1890s to a decline in the price of quinine but the quality and production of raw bark by the Dutch in Indonesia led them to dominate world markets. The producers of processed drugs in Europe (especially Germany) however bargained and caused fluctuations in prices which led to a Dutch-led Cinchona Agreement in 1913 that ensured a
Transdermal analgesic patch Transdermal analgesic patch A transdermal analgesic or pain relief patch is a medicated adhesive patch used to relieve minor to severe pain. There are two primary types of analgesic patches: patches containing counterirritants, which are used to treat mild to moderate pain, and patches containing fentanyl, a narcotic used to relieve moderate to severe pain in opioid-tolerant patients. Counterirritant patches contain ingredients such as capsaicin, methyl salicylate, camphor, or menthol, which are thought to mask pain signals by causing other sensations (itching, warmth, or cooling) in the areas they are applied to. In the United States, patches sold under the