Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
Biodiversity and drugs example, caffeine, methyl salicylate and quinine. Streptomycin, neomycin, and erythromycin are derived from tropical soil fungi. A lot of plant species are used in today's studies and have been exhaustively studied for their potential value as source of drugs. It is possible that some plant species may be a source of drugs against high blood pressure, AIDS or heart troubles. In China, Japan, India and Germany, there is a great deal of interest in and support for the search for new drugs from higher plants. Each species carries unique genetic material in its DNA and in its chemical factory responding