Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
What Degree? Which University? their studying experiences. Handley resurrected the concept in 2010 with the help of a team of undergraduate students, and launched "What Degree? Which University?" as a website in August 2011. Six months after its launch, "What Degree? Which University?" had attracted more than 22,000 visitors and expanded to provide information about universities across Australia. Today, the website covers 23 Australian universities and is staffed by 17 undergraduate and postgraduate students Australia-wide, who manage and produce the content for the site. "What Degree? Which University?" claims to have had 77,500 visits to the website (55,000 of which being unique visitors) and