Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
What Are The Theosophists? often attracted all sorts of neurotics, hysterics and even madmen: "All organisations which depend on enthusiasm and opposition to conventional opinion suffer from this problem to some degree; Theosophy appears to have been especially prone to it. The permanent residents at Adyar during the 1880s and '90s were typical. A quarrelsome collection of minor English aristocrats, rich American widows, German professors, Indian mystics and hangerson of every description, they were all eager to have their say, especially during Olcott's prolonged absences, and all ready to quarrel with one another." What Are The Theosophists? "What Are The Theosophists?" is an editorial