Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Drugs in Cambodia had established a ring to transport synthetic drugs from Cambodia to Vietnam across the border for the drugs to be distributed in cafes, bars, and discos. According to initial investigators, the ring had been operating for nearly a decade The UNODC is mandated to assist Member States in their struggle against illicit drugs, crime and terrorism. The UNODC is also working with high ranking government officials to lower illicit drugs and corruption. The UNODC is constantly updated on the country’s drug control and crime prevention efforts. Drugs in Cambodia In Cambodia, drugs can be readily obtained and are easily accessible,