Quinine using the bark of the cinchona tree for that purpose. While its effect in treating malaria (and malaria-induced shivering) was unrelated to its effect in controlling shivering from rigors, it was a successful medicine against malaria. At the first opportunity, Salumbrino sent a small quantity to Rome for testing as a malaria treatment. In the years that followed, cinchona bark, known as Jesuit's bark or Peruvian bark, became one of the most valuable commodities shipped from Peru to Europe. When King Charles II was cured of malaria at the end of the 17th Century with quinine, it became popular in
Cinchona la Quina" (1793) with illustrations. He proposed a Spanish expedition to search for plants of commercial value which was approved in 1783 and was continued after his death in 1808 by his nephew Sinforoso Mutis. As demand for the bark increased the trees in the forests began to be destroyed. To maintain their monopoly on cinchona bark, Peru and surrounding countries began outlawing the export of cinchona seeds and saplings beginning in the early 19th century. The Colonial European powers considered growing the plant in other tropical parts. The French mission of 1743, of which de la Condamine was member,