Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
We Are All on Drugs was eventually released that way on early printings of the album, and on published sheet music. It was replaced on future printings (as well as on the CD single) with "I want to reach a higher plane/ where things will never be the same." An edited version of the song for MTV "We Are All in Love," changed "on drugs" to "in love" in the chorus. Patrick Wilson suggested having the edit be "We Are All on Hugs," which Cuomo thought was too "quirky." Brian Bell suggested the "in love" edit. Despite this edit the headline "WE ARE ALL ON