Malaria saved the lives of thousands of workers and helped develop the methods used in future public-health campaigns against the disease. The first effective treatment for malaria came from the bark of cinchona tree, which contains quinine. This tree grows on the slopes of the Andes, mainly in Peru. The indigenous peoples of Peru made a tincture of cinchona to control fever. Its effectiveness against malaria was found and the Jesuits introduced the treatment to Europe around 1640; by 1677, it was included in the London Pharmacopoeia as an antimalarial treatment. It was not until 1820 that the active ingredient, quinine,
Cinchona mention of the Countess suffering from fever although the Count himself had many malarial attacks. On account of numerous other discrepancies this is best treated as a legend. Quina bark was mentioned by Fray Antonio de La Calancha in 1638 as coming from a tree in Loja (Loxa). He noted that bark powder weighing about two coins was cast into water and drunk to cure fevers and "tertians". Jesuit Father Bernabé Cobo (1582–1657) also wrote on the "fever tree" in 1653. The legend was popularized in English literature by Markham in his writings and in 1874 he also published a