Quinine the Quechua, who are indigenous to Peru, Bolivia and Ecuador, to halt shivering due to low temperatures. The Quechuas would mix the ground bark of cinchona trees with sweetened water to offset the bark's bitter taste, thus producing tonic water. The Jesuits were the first to bring cinchona to Europe. The Spanish were aware of the medicinal properties of cinchona bark by the 1570s or earlier: Nicolás Monardes (1571) and Juan Fragoso (1572) both described a tree that was subsequently identified as the cinchona tree and whose bark was used to produce a drink to treat diarrhea. Quinine has been
Birch bark the phloem, kills the tree by preventing the flow of sap to the roots. To prevent it from rolling up during storage, the bark should be spread open and kept pressed flat. Birch bark can be cut with a sharp knife, and worked like cardboard. For sharp bending, the fold should be scored (scratched) first with a blunt stylus. Fresh bark can be worked as is; bark that has dried up (before or after collection) should be softened by steaming, by soaking in warm water, or over a fire. Birch bark was a valuable construction material in any part of