Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
What Degree? Which University? their studying experiences. Handley resurrected the concept in 2010 with the help of a team of undergraduate students, and launched "What Degree? Which University?" as a website in August 2011. Six months after its launch, "What Degree? Which University?" had attracted more than 22,000 visitors and expanded to provide information about universities across Australia. Today, the website covers 23 Australian universities and is staffed by 17 undergraduate and postgraduate students Australia-wide, who manage and produce the content for the site. "What Degree? Which University?" claims to have had 77,500 visits to the website (55,000 of which being unique visitors) and