Sybian wired remote control. Flexible moulded attachments are supplied which fit over the vibrating ridge and shaft which mostly have integrated dildos on their top. In use, the rider locates the dildo into their body cavity for internal stimulation while pressing their external erogenous parts on the vibrating ridge. According to its inventor Dave Lampert, the Sybian was first conceived in the 1970s, and developed in 1983. A prototype was built in 1985 from sheet metal mounted on a wooden frame with a vibrator projecting through an opening inside the housing; a second prototype became the basis for current production models.
A-type proanthocyanidin radical oxidation. Fragmentation patterns for A-type proanthocyanidins include heterocyclic ring fission (HRF), retro-Diels-Alder (RDA) fission, benzofuran-forming fission (BFF) and quinone methide fission (QM). The metabolism of type-A proanthocyanidins is significant since a large number of metabolites are detected in urine and feces soon after ingestion of foods rich in polymers, indicating rapid elimination and absence of physiological effect. Polymeric type-A proanthocyanidins are depolymerized into epicatechin units in the small intestine, then cleaved into smaller phenolic acids with no known biological role. "In vitro", A-type proanthocyanidins isolated from cranberry juice cocktail demonstrated anti-adhesion activity against "E. coli" binding to urinary tract