Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
What Degree? Which University? student life, student housing, and graduate opportunities for university leavers through the "Lifestyle", "Student Housing", "Survival Guide" and "After Uni" sections. The creator of "What Degree? Which University?" is David Handley, who is also the founding director of international sculpture exhibition, "Sculpture by the Sea". Handley first conceptualised "What Degree? Which University?" whilst studying his final year of Law at the University of Sydney. In 1988, "What Degree? Which University?" initially took form through university seminars held at the University of Sydney, allowing prospective students to compare degree options by hearing current and former students of undergraduate degree programs discuss