Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Masquerade in Blood the second and last for drummer Atomic Steif, since the former was arrested in 1996 for possession of drugs, while the latter left the band for personal reasons. "Masquerade in Blood" continues in the same crossover thrash vein as their previous studio effort "Get What You Deserve" (which was released in the previous year), however it is most notable for introducing a new groove metal style, with "overwhelming" death metal being present on select songs. AllMusic's Eduardo Rivadavia gave the album two stars out of five, noting it as being "something of a return to form" for the band. However,