Cinchona in quinology to examine the contents of these components in assays. The yields of quinine in the cultivated trees were low and it took a while to develop sustainable methods to extract bark. In the meantime Charles Ledger and his native assistant Manuel collected another species from Bolivia. Manuel was caught and beaten by Bolivian officials leading to his death but Ledger obtained seeds of high quality which were offered to the British who were uninterested, leading to the rest being sold to the Dutch. The Dutch saw its value and multiplied the stock. The species later named as "Cinchona
Analgesic potential hazards of topical anesthetics entering the bloodstream when applied in large doses to the skin without medical supervision. These topical anesthetics contain anesthetic drugs such as lidocaine, tetracaine, benzocaine, and prilocaine in a cream, ointment, or gel. The word "analgesic" derives from Greek "an-" (, "without"), "álgos" (, "pain"), and "-ikos" (, forming adjectives). Such drugs were usually known as anodynes before the 20th century. Some novel and investigational analgesics include subtype-selective voltage-gated sodium channel blockers such as funapide and raxatrigine, as well as multimodal agents such as ralfinamide.. Analgesic An analgesic or painkiller is any member of the