Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
We Are Drugs The band focused on continuous sessions that would take a song from conception to completion. No guidelines or definitions of what the music should be or sound like were permitted during the sessions; this allowed the band to create the music they felt in the time they were working on it. Lyrics and vocals for the track "Weightless," however, were completed outside of the initial sessions: Jenkins didn't complete either until September 13, 2016—only three weeks before the EP was released. Jenkins states that the EP's name is meant to tie into their preceding album "Dopamine", with drugs being something