Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Consumer import of prescription drugs a higher price in a different market. Businesses, manufacturers and drug retailers wish to control the supply of pharmaceuticals in their own marketplace. As such, if low-cost drugs entered a market from other lower-cost territories, what might develop is pure price-based selling. The TRIPS agreement is an example of a World Trade Organization treaty which regulates how drugs can be traded in the international marketplace. Some developing countries might receive access to lower-cost drugs through compulsory licenses. Compulsory licenses affect markets outside the country in which they are issued. Drugs which are legal in one place may not be legal