Cinchona genus is the source of a variety of alkaloids, the most familiar of which is quinine, an antipyretic (antifever) agent especially useful in treating malaria. Cinchona alkaloids include: They find use in organic chemistry as organocatalysts in asymmetric synthesis. Alongside the alkaloids, many cinchona barks contain cinchotannic acid, a particular tannin, which by oxidation rapidly yields a dark-coloured phlobaphene called red cinchonic, cinchono-fulvic acid or cinchona red. In 1934, efforts to make malaria drugs cheap and effective for use across countries led to the development of a standard called "totaquina" proposed by the Malaria Commission of the League of Nations.
Bark beater such as soaking the cloth in water. Bark beater In many traditional cultures, bark beaters were tools used to pound tree bark, to make the bark softer for the processing of barkcloth, which is used for making paper, and clothing. This tool has many different variations that are seen in indigenous cultures worldwide, yet all for a similar purpose. “In Mesoamerica, the earliest proven bark beaters are from the Maya area and its periphery, particularly the Pacific coastal plain of Guatemala and El Salvador, where they appear some 2,500 years ago.” Both forms of bark beaters (club-shaped, and racquet type)