Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
Masquerade in Blood the second and last for drummer Atomic Steif, since the former was arrested in 1996 for possession of drugs, while the latter left the band for personal reasons. "Masquerade in Blood" continues in the same crossover thrash vein as their previous studio effort "Get What You Deserve" (which was released in the previous year), however it is most notable for introducing a new groove metal style, with "overwhelming" death metal being present on select songs. AllMusic's Eduardo Rivadavia gave the album two stars out of five, noting it as being "something of a return to form" for the band. However,