Malaria saved the lives of thousands of workers and helped develop the methods used in future public-health campaigns against the disease. The first effective treatment for malaria came from the bark of cinchona tree, which contains quinine. This tree grows on the slopes of the Andes, mainly in Peru. The indigenous peoples of Peru made a tincture of cinchona to control fever. Its effectiveness against malaria was found and the Jesuits introduced the treatment to Europe around 1640; by 1677, it was included in the London Pharmacopoeia as an antimalarial treatment. It was not until 1820 that the active ingredient, quinine,
Cinchona knighted. For the role in establishing cinchona in Indonesia, Hasskarl was knighted with the Dutch order of the Lion. "Cinchona" species are used as food plants by the larvae of some Lepidoptera species, including the engrailed, the commander, and members of the genus "Endoclita", including "E. damor", "E. purpurescens" and "E. sericeus". "Cinchona pubescens" has grown uncontrolled on some islands such as the Galapagos where it has posed the risk of outcompeting native plant species. In herbalism, cinchona bark was used as an adulterant in Jesuit's bark or Peruvian bark which originally is thought to have referred to "Myroxylon peruiferum",