Discovery and development of statins Discovery and development of statins The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk factors for atherosclerosis which often leads to cardiovascular, cerebrovascular and peripheral vascular diseases. The statins inhibit cholesterol synthesis in the body and that leads to reduction in blood cholesterol levels, which is thought to reduce the risk of atherosclerosis and diseases caused by it. More than 100 years ago a German pathologist named Rudolf Virchow discovered that cholesterol was to be found in the artery
We Are All on Drugs was eventually released that way on early printings of the album, and on published sheet music. It was replaced on future printings (as well as on the CD single) with "I want to reach a higher plane/ where things will never be the same." An edited version of the song for MTV "We Are All in Love," changed "on drugs" to "in love" in the chorus. Patrick Wilson suggested having the edit be "We Are All on Hugs," which Cuomo thought was too "quirky." Brian Bell suggested the "in love" edit. Despite this edit the headline "WE ARE ALL ON