Statin either the LDL receptor or apolipoprotein B genes, both of which are responsible for LDL clearance from the blood. Statins remain a first-line treatment in familial hypercholesterolemia, although other cholesterol-reducing measures may be required. In people with homozygous deficiencies, statins may still prove helpful, albeit at high doses and in combination with other cholesterol-reducing medications. A 2014 meta-analysis found that statins could reduce the risk of contrast-induced nephropathy by 53% in people undergoing coronary angiography/percutaneous interventions. The effect was found to be stronger among those with preexisting kidney dysfunction or diabetes mellitus. The most important adverse side effects are muscle
Consumer import of prescription drugs a higher price in a different market. Businesses, manufacturers and drug retailers wish to control the supply of pharmaceuticals in their own marketplace. As such, if low-cost drugs entered a market from other lower-cost territories, what might develop is pure price-based selling. The TRIPS agreement is an example of a World Trade Organization treaty which regulates how drugs can be traded in the international marketplace. Some developing countries might receive access to lower-cost drugs through compulsory licenses. Compulsory licenses affect markets outside the country in which they are issued. Drugs which are legal in one place may not be legal