Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
What Are The Theosophists? What Are The Theosophists? "What Are The Theosophists?" is an editorial published in October 1879 in the theosophical magazine "The Theosophist." It was compiled by Helena Blavatsky and it was included the 2nd volume of the "Blavatsky Collected Writings." Arnold Kalnitsky wrote in his thesis that in this article "we find a rather expansive statement of... [Blavatsky's] thoughts at that moment about the status of the movement, the Theosophical Society, its objectives, and the issues it was confronting." He wrote that the article begins with a question whether the Theosophists "are they what they claim to be": researchers of the