Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Blood donation in India is illegal under the National Blood Transfusion Services Act 2007 and those found convicted may face a prison sentence of up to three months with fine. There are several parameters that determine the eligibility of an individual to donate blood. Guidelines laid down by the Ministry of Health, Government of India have to be followed by blood banks and organizations conducting blood donation camps. Individuals under certain conditions are deemed ineligible to donate blood: Human blood is covered under the definition of "drug" under the Drugs and Cosmetics Act, 1940. Blood bank activities are regulated under this act and they