Clarithromycin CYP3A4, involved in the metabolism of many other commonly prescribed drugs. Taking clarithromycin with other medications that are metabolized by CYP3A4 may lead to unexpected increases or decreases in drug levels. A few of the common interactions are listed below. Clarithromycin has been observed to have a dangerous interaction with colchicine as the result of inhibition of CYP3A4 metabolism and P-glycoprotein transport. Combining these two drugs may lead to fatal colchicine toxicity, particularly in patients with renal insufficiency. Taking clarithromycin concurrently with certain statins (a class of drugs used to reduce blood serum cholesterol levels) increases the risk of side
Drugs in Cambodia among the arrested. They were allegedly caught in possession of nearly half a kilo of methamphetamines and cocaine. The men potentially face life sentences if they are to be convicted. These recent developments and arrests only further emphasizes that Cambodia is cracking down on the drug trade which exists in the country. According to secretary-general of the National Authority to Combat Drugs they emphasized that ‘There will be further raids. We are cracking down hard on people who provide illegal drugs.’ On April 10, 2009, four drug traders and traffickers, including two Cambodian nationals were prosecuted and arrested. The four