Pleiotropy (drugs) can respond to them, because the endogenous ones are endocrine messengers. Pleiotropy (drugs) In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects. For example, statins are HMG-CoA reductase inhibitors that primarily act by decreasing cholesterol synthesis, but which are believed to have other beneficial effects, including acting as antioxidants and stabilizing atherosclerotic plaques. Steroid drugs, such as prednisone and prednisolone, have pleiotropic effects, including systemic ones, for the same reason that endogenous
We Are All on Drugs was eventually released that way on early printings of the album, and on published sheet music. It was replaced on future printings (as well as on the CD single) with "I want to reach a higher plane/ where things will never be the same." An edited version of the song for MTV "We Are All in Love," changed "on drugs" to "in love" in the chorus. Patrick Wilson suggested having the edit be "We Are All on Hugs," which Cuomo thought was too "quirky." Brian Bell suggested the "in love" edit. Despite this edit the headline "WE ARE ALL ON