Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
What Kind of an American are You? What Kind of an American are You? What Kind of an American are you?, also known as What Kind of American are you?, is a World War I era song released in 1917. Albert Von Tilzer composed the music. Lew Brown and Charles R. McCarron wrote the lyrics. The song was published by Broadway Music Co. of New York, New York. On the cover is a gray drawing of Uncle Sam pointing. A map of the United States is featured on the lower half of the cover. The song was written for voice and piano. The sheet music can be