Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
What Degree? Which University? 450,000 page visits. What Degree? Which University? What Degree? Which University? is a free university student-run website that profiles the major Australian tertiary education institutions and their degree programs, as well as providing advice on the university experience. Its aim is to assist prospective and current Australian undergraduate students to make informed university decisions. The "What Degree?" and "Which Uni?" sections of the website provide information on Australian universities and their degree programs, along with profiles of current and former students who are currently or have formerly been enrolled in degree programs at particular institutions. The website also provides articles