Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Drugs in Cambodia had established a ring to transport synthetic drugs from Cambodia to Vietnam across the border for the drugs to be distributed in cafes, bars, and discos. According to initial investigators, the ring had been operating for nearly a decade The UNODC is mandated to assist Member States in their struggle against illicit drugs, crime and terrorism. The UNODC is also working with high ranking government officials to lower illicit drugs and corruption. The UNODC is constantly updated on the country’s drug control and crime prevention efforts. Drugs in Cambodia In Cambodia, drugs can be readily obtained and are easily accessible,