Quinine London. It remained the antimalarial drug of choice until the 1940s, when other drugs took over. The form of quinine most effective in treating malaria was found by Charles Marie de La Condamine in 1737. In 1820, French researchers Pierre Joseph Pelletier and Joseph Bienaimé Caventou first isolated quinine from the bark of a tree in the genus "Cinchona" - probably "Cinchona officinalis" - and subsequently named the substance. The name was derived from the original Quechua (Inca) word for the cinchona tree bark, "quina" or "quina-quina", which means "bark of bark" or "holy bark". Prior to 1820, the bark
Bark pocket Bark pocket Bark pockets can be formed by inosculation, formation of a tree fork, encapsulation of a branch, joining together of an uneven trunk, or encapsulation of another object. During inosculation, the bark trapped between the two joining trunk becomes surrounded with wood once the trunks fuse. The resulting bark pocket formed during inosculation or in a tree fork is referred to as included bark. When a branch is encapsulated, the outer bark on the branch may remain inside the wood of the tree, as the trunk widens and grows around the branch. Bark pockets can be used as an