Discovery and development of statins different pharmacophore structure were found. This structure-based virtual screening procedure is considered promising for rational quest and optimization of potential novel HGMR inhibitors. Discovery and development of statins The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk factors for atherosclerosis which often leads to cardiovascular, cerebrovascular and peripheral vascular diseases. The statins inhibit cholesterol synthesis in the body and that leads to reduction in blood cholesterol levels, which is thought to reduce the risk of atherosclerosis and diseases caused
We Are Drugs The band focused on continuous sessions that would take a song from conception to completion. No guidelines or definitions of what the music should be or sound like were permitted during the sessions; this allowed the band to create the music they felt in the time they were working on it. Lyrics and vocals for the track "Weightless," however, were completed outside of the initial sessions: Jenkins didn't complete either until September 13, 2016—only three weeks before the EP was released. Jenkins states that the EP's name is meant to tie into their preceding album "Dopamine", with drugs being something