Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
What Degree? Which University? student life, student housing, and graduate opportunities for university leavers through the "Lifestyle", "Student Housing", "Survival Guide" and "After Uni" sections. The creator of "What Degree? Which University?" is David Handley, who is also the founding director of international sculpture exhibition, "Sculpture by the Sea". Handley first conceptualised "What Degree? Which University?" whilst studying his final year of Law at the University of Sydney. In 1988, "What Degree? Which University?" initially took form through university seminars held at the University of Sydney, allowing prospective students to compare degree options by hearing current and former students of undergraduate degree programs discuss