Statin either the LDL receptor or apolipoprotein B genes, both of which are responsible for LDL clearance from the blood. Statins remain a first-line treatment in familial hypercholesterolemia, although other cholesterol-reducing measures may be required. In people with homozygous deficiencies, statins may still prove helpful, albeit at high doses and in combination with other cholesterol-reducing medications. A 2014 meta-analysis found that statins could reduce the risk of contrast-induced nephropathy by 53% in people undergoing coronary angiography/percutaneous interventions. The effect was found to be stronger among those with preexisting kidney dysfunction or diabetes mellitus. The most important adverse side effects are muscle
Illegal drugs in Puerto Rico the Puerto Rican police have struggled to work together and some commentators have questioned the effectiveness of government drug policy. In the early 1990s, law enforcement began specifically targeting white collar drug users. By 2008 the tension was rising. The start of what some call the "drug war" was in 2009 in a conflict between Police and drug dealers which police wounded and killed two men. This occurred in Naranjito, Puerto Rico, the place where the drug dealers distributed their drugs to many places in Puerto Rico. In the house they found AK-47, M9 pistols and the drugs. Also they