Cinchona pubescens Cinchona pubescens Cinchona pubescens, also known as red cinchona and quina (Quechua) ( "Cascarilla, cinchona"; "quina-do-amazonas, quineira"), is native to Central and South America. It is known as a medicinal plant for its bark's high quinine content- and has similar uses to "Cinchona officinalis" in the production of quinine, most famously used for treatment of malaria. "C. pubescens" varies from small to large in size, growing to 10 meters in height (33 ft). When cut, the bark tends to turn red. Leaves are elliptical to oblate and thin. The leaves have pubescent teeth that turn red when they are older,
Analgesic tolerance, which may be of particular concern regarding patients suffering with chronic pain and requiring an analgesic over long periods. Opioid tolerance is often addressed with opioid rotation therapy in which a patient is routinely switched between two or more non-cross-tolerant opioid medications in order to prevent exceeding safe dosages in the attempt to achieve an adequate analgesic effect. Opioid tolerance should not be confused with opioid-induced hyperalgesia. The symptoms of these two conditions can appear very similar but the mechanism of action is different. Opioid-induced hyperalgesia is when exposure to opioids increases the sensation of pain (hyperalgesia) and can