Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
What Degree? Which University? 450,000 page visits. What Degree? Which University? What Degree? Which University? is a free university student-run website that profiles the major Australian tertiary education institutions and their degree programs, as well as providing advice on the university experience. Its aim is to assist prospective and current Australian undergraduate students to make informed university decisions. The "What Degree?" and "Which Uni?" sections of the website provide information on Australian universities and their degree programs, along with profiles of current and former students who are currently or have formerly been enrolled in degree programs at particular institutions. The website also provides articles