Consumer Reports Best Buy Drugs category; and cost less on average than other drugs in the category. Several of the Best Buys have been chosen because of their superior effectiveness or safety profile even though they may cost more. The project publishes Best Buy Drugs drug reports, the first three such reports covered Statins to reduce high cholesterol, heartburn drugs, and NSAIDs commonly used to treat arthritis. The project covers over 20 conditions and the most widely used drugs. The reports are published in web versions, and two-page PDF summaries in English and Spanish. More than half of all prescription drugs cause adverse effects—some serious
Discovery and development of statins because lipophilic statins passively and non-selectively diffuse into both hepatocyte and non-heptatocyte, while the hydrophilic statins rely largely on active transport into hepatocyte to exert their effects. High hepatoselectivity is thought to translate into reduced risk of adverse effects. It has been reported that the organic anion transporting polypeptide (OATP) is important for the hepatic uptake of hydrophilic statins such as rosuvastatin and pravastatin. OATP-C is expressed in liver tissue on the basolateral membrane of hepatocytes and is considered to be a potential contributor for the low IC for rosuvastatin in hepatocytes. Of the marketed statins, cerivastatin was the most