Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
The Young Blood Chronicles a parking lot, Joe at a gas station and Pete on a rooftop. The Vixens bring Pete, Andy and Joe to a dinner table, at which Patrick is already seated. They are strapped to chairs and hooked to intravenous drips. They are served blood wine, hookahs and snuffable colored powder resembling cocaine. The women then serve them cobbler, fruit and Patrick's organs. The drugs make them believe they are dancing with their captors and naked women wearing bloody animal masks, yet are left still bound to their chairs. The briefcase is delivered to a vehicle with the license plate "RATATAT".