Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Drugs in the Australian Football League the opportunity to come back and play AFL in the year 2017. Drugs in the Australian Football League The Australian Football League (AFL) started in 1897 and was originally called the Victorian Football League until the name was changed in 1990 due to the expansion to the other Australian states. AFL is seen as an iconic Australian sport which attracts large crowds averaging around 32,000 people per game. It is a very popular industry to be in since there are so many different job positions and roles. Drugs are usually known as a chemical compound that has an effect on