Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
Drugs in Cambodia had established a ring to transport synthetic drugs from Cambodia to Vietnam across the border for the drugs to be distributed in cafes, bars, and discos. According to initial investigators, the ring had been operating for nearly a decade The UNODC is mandated to assist Member States in their struggle against illicit drugs, crime and terrorism. The UNODC is also working with high ranking government officials to lower illicit drugs and corruption. The UNODC is constantly updated on the country’s drug control and crime prevention efforts. Drugs in Cambodia In Cambodia, drugs can be readily obtained and are easily accessible,