Cinchona in the year 1851. Mr. [Thaddäus] Haenke mentioned the existence of cinchona bark on his visit to Yuracares in 1796". (Source: Exploration of the Valley of the Amazon, by Lieut. Lardner Gibbon, USN. Vol.II, Ch.6, pp. 146-47.) The cultivation of cinchona led from the 1890s to a decline in the price of quinine but the quality and production of raw bark by the Dutch in Indonesia led them to dominate world markets. The producers of processed drugs in Europe (especially Germany) however bargained and caused fluctuations in prices which led to a Dutch-led Cinchona Agreement in 1913 that ensured a
Naturally aspirated engine some of the power loss that occurs as the aircraft climbs to higher altitudes. The advantages and disadvantages of a naturally aspirated engine in relation to a same-sized engine relying on forced induction include: Naturally aspirated engine A naturally aspirated engine is an internal combustion engine in which oxygen intake depends solely on atmospheric pressure and does not rely on forced induction through a turbocharger or a supercharger. Many sports cars specifically use naturally aspirated engines to avoid turbo lag. In a naturally aspirated engine, air for combustion (diesel cycle in a diesel engine or specific types of Otto cycle