Cinchona economically practical source of quinine, a drug that is still recommended for the treatment of "falciparum" malaria. The Italian botanist Pietro Castelli wrote a pamphlet noteworthy as being the first Italian publication to mention the cinchona. By the 1630s (or 1640s, depending on the reference), the bark was being exported to Europe. In the late 1640s, the method of use of the bark was noted in the "Schedula Romana." English King Charles II called upon Robert Talbor, who had become famous for his miraculous malaria cure. Because at that time the bark was in religious controversy, Talbor gave the king
Alexander von Humboldt a center of learning in the U.S., Humboldt met with some of the major scientific figures of the era, including chemist and anatomist Caspar Wistar, who pushed for compulsory smallpox vaccination, and botanist Benjamin Smith Barton, as well as physician Benjamin Rush, a signer of the Declaration of Independence, who wished to hear about cinchona bark from a South American tree, which cured fevers. Humboldt later published a treatise in English on cinchona. After arriving in Washington D.C, Humboldt held numerous intense discussions with Jefferson on both scientific matters and also his year-long stay in New Spain. Jefferson had only