Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
Drugs in the Australian Football League Drugs in the Australian Football League The Australian Football League (AFL) started in 1897 and was originally called the Victorian Football League until the name was changed in 1990 due to the expansion to the other Australian states. AFL is seen as an iconic Australian sport which attracts large crowds averaging around 32,000 people per game. It is a very popular industry to be in since there are so many different job positions and roles. Drugs are usually known as a chemical compound that has an effect on a persons body in some way, either physically or psychologically. Drugs specific