Cinchona ledgeriana" had a yield of 8 to 13 percent quinine in bark grown in Dutch Indonesia which effectively out-competed the British Indian production. It was only later that the English saw the value and sought to obtain the seeds of "C. ledgeriana" from the Dutch. During World War II, the Japanese conquered Java and the United States lost access to the cinchona plantations that supplied war-critical quinine medication. Botanical expeditions – called Cinchona Missions – were launched in 1942-1944 to explore promising areas of South America in an effort to locate cinchona species that contained quinine and could be harvested
Bark bread known from the 1890s, and in Finland "pettuleipä" (literally "pinewood-bark bread") was produced as ersatz bread during the Finnish Civil War of 1918. Finger sized twigs and branches were collected from deciduous trees and shrubs, and the bark split and the inner bark (the phloem and sometimes the vascular cambium) collected while still fresh. The yellow or green inner bark (depending on tree species) was dried over open fire, in an oven or dried in the sun for a few days. A mortar or mill was used to grind the bark to a fine powder to add to the flour.