Discovery and development of statins different pharmacophore structure were found. This structure-based virtual screening procedure is considered promising for rational quest and optimization of potential novel HGMR inhibitors. Discovery and development of statins The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk factors for atherosclerosis which often leads to cardiovascular, cerebrovascular and peripheral vascular diseases. The statins inhibit cholesterol synthesis in the body and that leads to reduction in blood cholesterol levels, which is thought to reduce the risk of atherosclerosis and diseases caused
We Are All on Drugs We Are All on Drugs "We Are All on Drugs" is a song by American alternative rock band Weezer. It was released as the second single from the band's 2005 album, "Make Believe". "We Are All on Drugs" was released to radio on July 12, 2005. The song is not specifically about drugs. Rather, Rivers Cuomo has said that it is more generally about the over-stimulated society addicted to the internet, gambling, drugs and relationships. The song went into mixing with two lines in the bridge:, "I want to confiscate your drugs/ I don't think I can get enough", and