Statin either the LDL receptor or apolipoprotein B genes, both of which are responsible for LDL clearance from the blood. Statins remain a first-line treatment in familial hypercholesterolemia, although other cholesterol-reducing measures may be required. In people with homozygous deficiencies, statins may still prove helpful, albeit at high doses and in combination with other cholesterol-reducing medications. A 2014 meta-analysis found that statins could reduce the risk of contrast-induced nephropathy by 53% in people undergoing coronary angiography/percutaneous interventions. The effect was found to be stronger among those with preexisting kidney dysfunction or diabetes mellitus. The most important adverse side effects are muscle
We Are Drugs to finish them after the band finished touring to support "Dopamine"—he would want to release. Several months later, Jenkins began discussing plans for a new EP release in mid-2016. Contrary to the band's previous few albums—"Out of the Vein" (2003), "Ursa Major" (2009), and "Dopamine" (2015), which were recorded over the course of four to six years—the band was limited to only one week in a studio in Texas in early 2016 to record "We Are Drugs". Jenkins stated that the success of "Dopamine" finally allowed him to stop obsessing over perfecting lyrics, something he had done in the past.