Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Drugs in the Australian Football League Drugs in the Australian Football League The Australian Football League (AFL) started in 1897 and was originally called the Victorian Football League until the name was changed in 1990 due to the expansion to the other Australian states. AFL is seen as an iconic Australian sport which attracts large crowds averaging around 32,000 people per game. It is a very popular industry to be in since there are so many different job positions and roles. Drugs are usually known as a chemical compound that has an effect on a persons body in some way, either physically or psychologically. Drugs specific