Clarithromycin CYP3A4, involved in the metabolism of many other commonly prescribed drugs. Taking clarithromycin with other medications that are metabolized by CYP3A4 may lead to unexpected increases or decreases in drug levels. A few of the common interactions are listed below. Clarithromycin has been observed to have a dangerous interaction with colchicine as the result of inhibition of CYP3A4 metabolism and P-glycoprotein transport. Combining these two drugs may lead to fatal colchicine toxicity, particularly in patients with renal insufficiency. Taking clarithromycin concurrently with certain statins (a class of drugs used to reduce blood serum cholesterol levels) increases the risk of side
Illegal drugs in Puerto Rico the Puerto Rican police have struggled to work together and some commentators have questioned the effectiveness of government drug policy. In the early 1990s, law enforcement began specifically targeting white collar drug users. By 2008 the tension was rising. The start of what some call the "drug war" was in 2009 in a conflict between Police and drug dealers which police wounded and killed two men. This occurred in Naranjito, Puerto Rico, the place where the drug dealers distributed their drugs to many places in Puerto Rico. In the house they found AK-47, M9 pistols and the drugs. Also they