Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
Drugs in the Australian Football League Drugs in the Australian Football League The Australian Football League (AFL) started in 1897 and was originally called the Victorian Football League until the name was changed in 1990 due to the expansion to the other Australian states. AFL is seen as an iconic Australian sport which attracts large crowds averaging around 32,000 people per game. It is a very popular industry to be in since there are so many different job positions and roles. Drugs are usually known as a chemical compound that has an effect on a persons body in some way, either physically or psychologically. Drugs specific