Pleiotropy (drugs) can respond to them, because the endogenous ones are endocrine messengers. Pleiotropy (drugs) In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects. For example, statins are HMG-CoA reductase inhibitors that primarily act by decreasing cholesterol synthesis, but which are believed to have other beneficial effects, including acting as antioxidants and stabilizing atherosclerotic plaques. Steroid drugs, such as prednisone and prednisolone, have pleiotropic effects, including systemic ones, for the same reason that endogenous
Masquerade in Blood the second and last for drummer Atomic Steif, since the former was arrested in 1996 for possession of drugs, while the latter left the band for personal reasons. "Masquerade in Blood" continues in the same crossover thrash vein as their previous studio effort "Get What You Deserve" (which was released in the previous year), however it is most notable for introducing a new groove metal style, with "overwhelming" death metal being present on select songs. AllMusic's Eduardo Rivadavia gave the album two stars out of five, noting it as being "something of a return to form" for the band. However,