Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
We Are All on Drugs be a cool song."" In a May 9th, 2005 interview with Y100, Cuomo talked about the song: "Don't take it literally...I'm singing more about the fact [of] how addicted we all are to stimulating ourselves, and over-stimulating ourselves with music, or whatever it is in our lives. [It's] not necessarily about drugs." UK Retail 7" (Pink Vinyl) UK Retail CD We Are All on Drugs "We Are All on Drugs" is a song by American alternative rock band Weezer. It was released as the second single from the band's 2005 album, "Make Believe". "We Are All on Drugs" was released