Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
What Degree? Which University? student life, student housing, and graduate opportunities for university leavers through the "Lifestyle", "Student Housing", "Survival Guide" and "After Uni" sections. The creator of "What Degree? Which University?" is David Handley, who is also the founding director of international sculpture exhibition, "Sculpture by the Sea". Handley first conceptualised "What Degree? Which University?" whilst studying his final year of Law at the University of Sydney. In 1988, "What Degree? Which University?" initially took form through university seminars held at the University of Sydney, allowing prospective students to compare degree options by hearing current and former students of undergraduate degree programs discuss