Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
What Kind of an American are You? What Kind of an American are You? What Kind of an American are you?, also known as What Kind of American are you?, is a World War I era song released in 1917. Albert Von Tilzer composed the music. Lew Brown and Charles R. McCarron wrote the lyrics. The song was published by Broadway Music Co. of New York, New York. On the cover is a gray drawing of Uncle Sam pointing. A map of the United States is featured on the lower half of the cover. The song was written for voice and piano. The sheet music can be