Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
Blood bike by the national charity Blood Bikes with other emergency vehicles"". In 2016 there were more than thirty local groups operating in the UK and Ireland. These include: Blood bike A blood bike is a motorcycle used to courier urgent and emergency medical items including blood, X-rays, samples, drugs, and documentation between hospitals and other healthcare facilities. In the United Kingdom and Ireland a network of largely independent registered charities, whose members are all unpaid volunteers, provide blood bike courier services in collaboration with their local healthcare authorities. Many are represented through the Nationwide Association of Blood Bikes (NABB). Commercial blood