Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
What Kind of an American are You? What Kind of an American are You? What Kind of an American are you?, also known as What Kind of American are you?, is a World War I era song released in 1917. Albert Von Tilzer composed the music. Lew Brown and Charles R. McCarron wrote the lyrics. The song was published by Broadway Music Co. of New York, New York. On the cover is a gray drawing of Uncle Sam pointing. A map of the United States is featured on the lower half of the cover. The song was written for voice and piano. The sheet music can be