Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
What Kind of an American are You? What Kind of an American are You? What Kind of an American are you?, also known as What Kind of American are you?, is a World War I era song released in 1917. Albert Von Tilzer composed the music. Lew Brown and Charles R. McCarron wrote the lyrics. The song was published by Broadway Music Co. of New York, New York. On the cover is a gray drawing of Uncle Sam pointing. A map of the United States is featured on the lower half of the cover. The song was written for voice and piano. The sheet music can be