Pleiotropy (drugs) can respond to them, because the endogenous ones are endocrine messengers. Pleiotropy (drugs) In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects. For example, statins are HMG-CoA reductase inhibitors that primarily act by decreasing cholesterol synthesis, but which are believed to have other beneficial effects, including acting as antioxidants and stabilizing atherosclerotic plaques. Steroid drugs, such as prednisone and prednisolone, have pleiotropic effects, including systemic ones, for the same reason that endogenous
What Are The Theosophists? often attracted all sorts of neurotics, hysterics and even madmen: "All organisations which depend on enthusiasm and opposition to conventional opinion suffer from this problem to some degree; Theosophy appears to have been especially prone to it. The permanent residents at Adyar during the 1880s and '90s were typical. A quarrelsome collection of minor English aristocrats, rich American widows, German professors, Indian mystics and hangerson of every description, they were all eager to have their say, especially during Olcott's prolonged absences, and all ready to quarrel with one another." What Are The Theosophists? "What Are The Theosophists?" is an editorial