Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
Drugs in Cambodia had established a ring to transport synthetic drugs from Cambodia to Vietnam across the border for the drugs to be distributed in cafes, bars, and discos. According to initial investigators, the ring had been operating for nearly a decade The UNODC is mandated to assist Member States in their struggle against illicit drugs, crime and terrorism. The UNODC is also working with high ranking government officials to lower illicit drugs and corruption. The UNODC is constantly updated on the country’s drug control and crime prevention efforts. Drugs in Cambodia In Cambodia, drugs can be readily obtained and are easily accessible,