Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Illegal drugs in Puerto Rico the Puerto Rican police have struggled to work together and some commentators have questioned the effectiveness of government drug policy. In the early 1990s, law enforcement began specifically targeting white collar drug users. By 2008 the tension was rising. The start of what some call the "drug war" was in 2009 in a conflict between Police and drug dealers which police wounded and killed two men. This occurred in Naranjito, Puerto Rico, the place where the drug dealers distributed their drugs to many places in Puerto Rico. In the house they found AK-47, M9 pistols and the drugs. Also they