Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Blood donation in India is illegal under the National Blood Transfusion Services Act 2007 and those found convicted may face a prison sentence of up to three months with fine. There are several parameters that determine the eligibility of an individual to donate blood. Guidelines laid down by the Ministry of Health, Government of India have to be followed by blood banks and organizations conducting blood donation camps. Individuals under certain conditions are deemed ineligible to donate blood: Human blood is covered under the definition of "drug" under the Drugs and Cosmetics Act, 1940. Blood bank activities are regulated under this act and they