Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
Drugs in Cambodia produced and traffickers export these drugs out of the country and or shipped throughout neighboring nations. The Ruak and Mekong rivers of these areas also influences the ease of how drugs are transported through this area. The drugs are transported through the Triangle by horse and donkey caravans to refineries where the drugs are further processed and refined to become more pure. They are then most frequently brought to the United States and other countries by couriers traveling on commercial airlines or they are smuggled into the country by shipping containers. Teng Bunma is one of the wealthiest people in