Cinchona genus is the source of a variety of alkaloids, the most familiar of which is quinine, an antipyretic (antifever) agent especially useful in treating malaria. Cinchona alkaloids include: They find use in organic chemistry as organocatalysts in asymmetric synthesis. Alongside the alkaloids, many cinchona barks contain cinchotannic acid, a particular tannin, which by oxidation rapidly yields a dark-coloured phlobaphene called red cinchonic, cinchono-fulvic acid or cinchona red. In 1934, efforts to make malaria drugs cheap and effective for use across countries led to the development of a standard called "totaquina" proposed by the Malaria Commission of the League of Nations.
Bark mill used extensively in France, Weldon’s bark-grinding mill, and a device known as a Wiltze’s or Catskill's mill, prevalent in 19th-century America. The Swansea, Tasmania bark Mill processed black wattle bark in colonial times and is now a combined museum. Bark mill Bark mills, also known as Catskill’s mills, were water, steam, horse, ox or wind-powered edge mills used to process the bark, roots, and branches of various tree species into a fine powder known as tanbark, used for tanning leather. This powdering allowed the tannin to be extracted more efficiently from its woody source material. A barker would strip the