Cinchona genus is the source of a variety of alkaloids, the most familiar of which is quinine, an antipyretic (antifever) agent especially useful in treating malaria. Cinchona alkaloids include: They find use in organic chemistry as organocatalysts in asymmetric synthesis. Alongside the alkaloids, many cinchona barks contain cinchotannic acid, a particular tannin, which by oxidation rapidly yields a dark-coloured phlobaphene called red cinchonic, cinchono-fulvic acid or cinchona red. In 1934, efforts to make malaria drugs cheap and effective for use across countries led to the development of a standard called "totaquina" proposed by the Malaria Commission of the League of Nations.
Bark (botany) the ground to where the main branching starts) of the tree. Bark tissues make up by weight between 10–20% of woody vascular plants and consists of various biopolymers, tannins, lignin, suberin, suberan and polysaccharides. Up to 40% of the bark tissue is made of lignin which forms an important part of a plant providing structural support by crosslinking between different polysaccharides, such as cellulose. Condensed tannin, which are in fairly high concentration in bark tissue, is thought to inhibit decomposition. It could be due to this factor that the degradation of lignin is far less pronounced in bark tissue than