Malaria saved the lives of thousands of workers and helped develop the methods used in future public-health campaigns against the disease. The first effective treatment for malaria came from the bark of cinchona tree, which contains quinine. This tree grows on the slopes of the Andes, mainly in Peru. The indigenous peoples of Peru made a tincture of cinchona to control fever. Its effectiveness against malaria was found and the Jesuits introduced the treatment to Europe around 1640; by 1677, it was included in the London Pharmacopoeia as an antimalarial treatment. It was not until 1820 that the active ingredient, quinine,
Tree from the cinchona tree ("Cinchona") and was for a long time the remedy of choice for the treatment of malaria. Aspirin was synthesised to replace the sodium salicylate derived from the bark of willow trees ("Salix") which had unpleasant side effects. The anti-cancer drug Paclitaxel is derived from taxol, a substance found in the bark of the Pacific yew ("Taxus brevifolia"). Other tree based drugs come from the paw-paw ("Carica papaya"), the cassia ("Cassia spp."), the cocoa tree ("Theobroma cacao"), the tree of life ("Camptotheca acuminata") and the downy birch ("Betula pubescens"). The papery bark of the white birch tree