Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Drugs in Cambodia produced and traffickers export these drugs out of the country and or shipped throughout neighboring nations. The Ruak and Mekong rivers of these areas also influences the ease of how drugs are transported through this area. The drugs are transported through the Triangle by horse and donkey caravans to refineries where the drugs are further processed and refined to become more pure. They are then most frequently brought to the United States and other countries by couriers traveling on commercial airlines or they are smuggled into the country by shipping containers. Teng Bunma is one of the wealthiest people in