Cinchona for quinine production. While ultimately successful in their primary aim, these expeditions also identified new species of plants and created a new chapter in international relations between the United States and other nations in the Americas. Francesco Torti used the response of fevers to treatment with cinchona as a system of classification of fevers or a means for diagnosis. The use of cinchona in the effective treatment of malaria brought an end to treatment by bloodletting and long-held ideas of humorism from Galen. For his part in obtaining and helping the establishment of cinchona in British India Clements Markham was
Alexander von Humboldt a center of learning in the U.S., Humboldt met with some of the major scientific figures of the era, including chemist and anatomist Caspar Wistar, who pushed for compulsory smallpox vaccination, and botanist Benjamin Smith Barton, as well as physician Benjamin Rush, a signer of the Declaration of Independence, who wished to hear about cinchona bark from a South American tree, which cured fevers. Humboldt later published a treatise in English on cinchona. After arriving in Washington D.C, Humboldt held numerous intense discussions with Jefferson on both scientific matters and also his year-long stay in New Spain. Jefferson had only