Coenzyme Q10 be measured in blood plasma, these measurements reflect dietary intake rather than tissue status. Currently, most clinical centers measure CoQ levels in cultured skin fibroblasts, muscle biopsies, and blood mononuclear cells. Culture fibroblasts can be used also to evaluate the rate of endogenous CoQ biosynthesis, by measuring the uptake of C-labelled "p"-hydroxybenzoate. CoQ shares a biosynthetic pathway with cholesterol. The synthesis of an intermediary precursor of CoQ, mevalonate, is inhibited by some beta blockers, blood pressure-lowering medication, and statins, a class of cholesterol-lowering drugs. Statins can reduce serum levels of CoQ by up to 40%. CoQ is not approved by
Consumer import of prescription drugs a higher price in a different market. Businesses, manufacturers and drug retailers wish to control the supply of pharmaceuticals in their own marketplace. As such, if low-cost drugs entered a market from other lower-cost territories, what might develop is pure price-based selling. The TRIPS agreement is an example of a World Trade Organization treaty which regulates how drugs can be traded in the international marketplace. Some developing countries might receive access to lower-cost drugs through compulsory licenses. Compulsory licenses affect markets outside the country in which they are issued. Drugs which are legal in one place may not be legal