Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
We Are All on Drugs be a cool song."" In a May 9th, 2005 interview with Y100, Cuomo talked about the song: "Don't take it literally...I'm singing more about the fact [of] how addicted we all are to stimulating ourselves, and over-stimulating ourselves with music, or whatever it is in our lives. [It's] not necessarily about drugs." UK Retail 7" (Pink Vinyl) UK Retail CD We Are All on Drugs "We Are All on Drugs" is a song by American alternative rock band Weezer. It was released as the second single from the band's 2005 album, "Make Believe". "We Are All on Drugs" was released