Stanol ester Stanol ester Stanol ester is a heterogeneous group of chemical compounds known to reduce the level of low-density lipoprotein (LDL) cholesterol in blood when ingested, though to a much lesser degree than prescription drugs such as statins. The starting material is phytosterols from plants. These are first hydrogenated to give a plant stanol which is then esterified with a mixture of fatty acids also derived from plants. Plant stanol esters are found naturally occurring in small quantities in fruits, vegetables, nuts, seeds, cereals, legumes, and vegetable oils. Stanol ester is often added to rapeseed oil based margarine or other foods
Discovery and development of statins 3R,5R stereochemistry. The statins differ with respect to their ring structure and substituents. These differences in structure affect the pharmacological properties of the statins, such as: Statins have sometimes been grouped into two groups of statins according to their structure. Type 1 statins Statins that have substituted decalin-ring structure that resemble the first statin ever discovered, mevastatin have often been classified as type 1 statins due to their structural relationship. Statins that belong to this group are: Type 2 statins Statins that are fully synthetic and have larger groups linked to the HMG-like moiety are often referred to as type