Cinchona genus is the source of a variety of alkaloids, the most familiar of which is quinine, an antipyretic (antifever) agent especially useful in treating malaria. Cinchona alkaloids include: They find use in organic chemistry as organocatalysts in asymmetric synthesis. Alongside the alkaloids, many cinchona barks contain cinchotannic acid, a particular tannin, which by oxidation rapidly yields a dark-coloured phlobaphene called red cinchonic, cinchono-fulvic acid or cinchona red. In 1934, efforts to make malaria drugs cheap and effective for use across countries led to the development of a standard called "totaquina" proposed by the Malaria Commission of the League of Nations.
Bark mill Bark mill Bark mills, also known as Catskill’s mills, were water, steam, horse, ox or wind-powered edge mills used to process the bark, roots, and branches of various tree species into a fine powder known as tanbark, used for tanning leather. This powdering allowed the tannin to be extracted more efficiently from its woody source material. A barker would strip the bark from trees so that it might be ground in such mills, and the dried bark was often stored in bark houses. Various machinery was used to chop, grind, riddle and pound the bark. These included Farcot’s bark-cutting machine,