Cinchona genus is the source of a variety of alkaloids, the most familiar of which is quinine, an antipyretic (antifever) agent especially useful in treating malaria. Cinchona alkaloids include: They find use in organic chemistry as organocatalysts in asymmetric synthesis. Alongside the alkaloids, many cinchona barks contain cinchotannic acid, a particular tannin, which by oxidation rapidly yields a dark-coloured phlobaphene called red cinchonic, cinchono-fulvic acid or cinchona red. In 1934, efforts to make malaria drugs cheap and effective for use across countries led to the development of a standard called "totaquina" proposed by the Malaria Commission of the League of Nations.
Christmas tree production in the United States million Christmas trees valued at approximately $120 million. The majority of Christmas tree production occurs in the Willamette Valley region including Benton, Clackamas, Marion, Polk and Yamhill counties. In 2015, Washington State had approximately 250 Christmas tree farms with a combined 23,000 acres, yielding 2.3 million Christmas trees valued at approximately $35 million. The majority of Christmas tree production occurs in the western and southern portions of the Puget Sound region including Kitsap, Lewis, Mason and Thurston counties. Aside from Pennsylvania, several U.S. states in the Great Lakes region are key Christmas tree producers. The two most important production areas