Quinine London. It remained the antimalarial drug of choice until the 1940s, when other drugs took over. The form of quinine most effective in treating malaria was found by Charles Marie de La Condamine in 1737. In 1820, French researchers Pierre Joseph Pelletier and Joseph Bienaimé Caventou first isolated quinine from the bark of a tree in the genus "Cinchona" - probably "Cinchona officinalis" - and subsequently named the substance. The name was derived from the original Quechua (Inca) word for the cinchona tree bark, "quina" or "quina-quina", which means "bark of bark" or "holy bark". Prior to 1820, the bark
Cinchona people. Italian sources spelt Quina as Cina which was a source of confusion with "Smilax" from China. Haggis argued that Qina and Jesuit's bark actually referred to "Myroxylon peruiferum" or Peruvian balsam and that this was an item of importance in Spanish trade in the 1500s. Over time, the bark of the "Myroxylon" was adulterated with the similar looking bark of what we now know as "Cinchona". Gradually the adulterant became the main product that was the key therapeutic ingredient used in malarial therapy. The bark was included as "Cortex Peruanus" in the London Pharmacopoeia in 1677. The "fever tree"