Psittacosis the 1920s–1930s outbreak in humans, a specific reservoir for serovar E has not been identified. The M56 and WC serovars were isolated during outbreaks in mammals. Treatment is usually with antibiotics, such as doxycycline or tetracycline, and can be administered through drops in the water or injections. Many strains of "C. psittaci" are susceptible to bacteriophages. Psittacosis was one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological weapons program. The most high-profile death caused by parrot fever is that of Thea Selway, mother of Radiohead drummer and
Niemann–Pick disease bone called coxa vara. Sleep-related disorders, such as sleep inversion, sleepiness during the day and wakefulness at night, may occur. Gelastic cataplexy, the sudden loss of muscle tone when the affected patient laughs, is also seen. Mutations in the "SMPD1" gene cause Niemann–Pick disease types A and B. They produce a deficiency in the activity of the lysosomal enzyme acid sphingomyelinase, that breaks down the lipid sphingomyelin. Mutations in "NPC1" or "NPC2" cause Niemann–Pick disease, type C (NPC), which affects a protein used to transport lipids. Type D originally was separated from type C to delineate a group of patients