Malaria saved the lives of thousands of workers and helped develop the methods used in future public-health campaigns against the disease. The first effective treatment for malaria came from the bark of cinchona tree, which contains quinine. This tree grows on the slopes of the Andes, mainly in Peru. The indigenous peoples of Peru made a tincture of cinchona to control fever. Its effectiveness against malaria was found and the Jesuits introduced the treatment to Europe around 1640; by 1677, it was included in the London Pharmacopoeia as an antimalarial treatment. It was not until 1820 that the active ingredient, quinine,
Bark pocket Bark pocket Bark pockets can be formed by inosculation, formation of a tree fork, encapsulation of a branch, joining together of an uneven trunk, or encapsulation of another object. During inosculation, the bark trapped between the two joining trunk becomes surrounded with wood once the trunks fuse. The resulting bark pocket formed during inosculation or in a tree fork is referred to as included bark. When a branch is encapsulated, the outer bark on the branch may remain inside the wood of the tree, as the trunk widens and grows around the branch. Bark pockets can be used as an