Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
What Degree? Which University? What Degree? Which University? What Degree? Which University? is a free university student-run website that profiles the major Australian tertiary education institutions and their degree programs, as well as providing advice on the university experience. Its aim is to assist prospective and current Australian undergraduate students to make informed university decisions. The "What Degree?" and "Which Uni?" sections of the website provide information on Australian universities and their degree programs, along with profiles of current and former students who are currently or have formerly been enrolled in degree programs at particular institutions. The website also provides articles and information on