Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
What Are The Theosophists? What Are The Theosophists? "What Are The Theosophists?" is an editorial published in October 1879 in the theosophical magazine "The Theosophist." It was compiled by Helena Blavatsky and it was included the 2nd volume of the "Blavatsky Collected Writings." Arnold Kalnitsky wrote in his thesis that in this article "we find a rather expansive statement of... [Blavatsky's] thoughts at that moment about the status of the movement, the Theosophical Society, its objectives, and the issues it was confronting." He wrote that the article begins with a question whether the Theosophists "are they what they claim to be": researchers of the