Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Religion and drugs encourage or require teetotalism. In some Protestant denomination, grape juice or non-alcoholic wine is used in place of wine to represent the blood of Christ. The best known Western prohibition against alcohol happened in the United States in the 1920s, where concerned prohibitionists were worried about its dangerous side effects. However, the demand for alcohol remained and criminals stepped in and created the supply. The consequences of organized crime and the popular demand for alcohol, led to alcohol being legalized again. Islam prohibits all drugs that are not medically prescribed. Islam's prohibition of drugs stems from two concerns: There are