Discovery and development of statins different pharmacophore structure were found. This structure-based virtual screening procedure is considered promising for rational quest and optimization of potential novel HGMR inhibitors. Discovery and development of statins The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk factors for atherosclerosis which often leads to cardiovascular, cerebrovascular and peripheral vascular diseases. The statins inhibit cholesterol synthesis in the body and that leads to reduction in blood cholesterol levels, which is thought to reduce the risk of atherosclerosis and diseases caused
Biodiversity and drugs example, caffeine, methyl salicylate and quinine. Streptomycin, neomycin, and erythromycin are derived from tropical soil fungi. A lot of plant species are used in today's studies and have been exhaustively studied for their potential value as source of drugs. It is possible that some plant species may be a source of drugs against high blood pressure, AIDS or heart troubles. In China, Japan, India and Germany, there is a great deal of interest in and support for the search for new drugs from higher plants. Each species carries unique genetic material in its DNA and in its chemical factory responding