Cinchona ledgeriana" had a yield of 8 to 13 percent quinine in bark grown in Dutch Indonesia which effectively out-competed the British Indian production. It was only later that the English saw the value and sought to obtain the seeds of "C. ledgeriana" from the Dutch. During World War II, the Japanese conquered Java and the United States lost access to the cinchona plantations that supplied war-critical quinine medication. Botanical expeditions – called Cinchona Missions – were launched in 1942-1944 to explore promising areas of South America in an effort to locate cinchona species that contained quinine and could be harvested
Cinchona was finally described carefully by the astronomer Charles Marie de la Condamine who visited Quito in 1735 on a quest to measure an arc of the meridian. The species he described, "Cinchona officinalis," was however found to be of little therapeutic value. The first living plants seen in Europe were "C. calisaya" plants grown at the "Jardin des Plantes" from seeds collected by Hugh Algernon Weddell from Bolivia in 1846. José Celestino Mutis, physician to the Viceroy of Nueva Granada, Pedro Messia de la Cerda gathered information on cinchona in Colombia from 1760 and wrote a manuscript "El Arcano de