Pleiotropy (drugs) can respond to them, because the endogenous ones are endocrine messengers. Pleiotropy (drugs) In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects. For example, statins are HMG-CoA reductase inhibitors that primarily act by decreasing cholesterol synthesis, but which are believed to have other beneficial effects, including acting as antioxidants and stabilizing atherosclerotic plaques. Steroid drugs, such as prednisone and prednisolone, have pleiotropic effects, including systemic ones, for the same reason that endogenous
We Are Drugs to finish them after the band finished touring to support "Dopamine"—he would want to release. Several months later, Jenkins began discussing plans for a new EP release in mid-2016. Contrary to the band's previous few albums—"Out of the Vein" (2003), "Ursa Major" (2009), and "Dopamine" (2015), which were recorded over the course of four to six years—the band was limited to only one week in a studio in Texas in early 2016 to record "We Are Drugs". Jenkins stated that the success of "Dopamine" finally allowed him to stop obsessing over perfecting lyrics, something he had done in the past.