Clarithromycin CYP3A4, involved in the metabolism of many other commonly prescribed drugs. Taking clarithromycin with other medications that are metabolized by CYP3A4 may lead to unexpected increases or decreases in drug levels. A few of the common interactions are listed below. Clarithromycin has been observed to have a dangerous interaction with colchicine as the result of inhibition of CYP3A4 metabolism and P-glycoprotein transport. Combining these two drugs may lead to fatal colchicine toxicity, particularly in patients with renal insufficiency. Taking clarithromycin concurrently with certain statins (a class of drugs used to reduce blood serum cholesterol levels) increases the risk of side
Religion and drugs encourage or require teetotalism. In some Protestant denomination, grape juice or non-alcoholic wine is used in place of wine to represent the blood of Christ. The best known Western prohibition against alcohol happened in the United States in the 1920s, where concerned prohibitionists were worried about its dangerous side effects. However, the demand for alcohol remained and criminals stepped in and created the supply. The consequences of organized crime and the popular demand for alcohol, led to alcohol being legalized again. Islam prohibits all drugs that are not medically prescribed. Islam's prohibition of drugs stems from two concerns: There are