Discovery and development of statins different pharmacophore structure were found. This structure-based virtual screening procedure is considered promising for rational quest and optimization of potential novel HGMR inhibitors. Discovery and development of statins The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk factors for atherosclerosis which often leads to cardiovascular, cerebrovascular and peripheral vascular diseases. The statins inhibit cholesterol synthesis in the body and that leads to reduction in blood cholesterol levels, which is thought to reduce the risk of atherosclerosis and diseases caused
The Young Blood Chronicles a parking lot, Joe at a gas station and Pete on a rooftop. The Vixens bring Pete, Andy and Joe to a dinner table, at which Patrick is already seated. They are strapped to chairs and hooked to intravenous drips. They are served blood wine, hookahs and snuffable colored powder resembling cocaine. The women then serve them cobbler, fruit and Patrick's organs. The drugs make them believe they are dancing with their captors and naked women wearing bloody animal masks, yet are left still bound to their chairs. The briefcase is delivered to a vehicle with the license plate "RATATAT".