Discovery and development of statins different pharmacophore structure were found. This structure-based virtual screening procedure is considered promising for rational quest and optimization of potential novel HGMR inhibitors. Discovery and development of statins The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk factors for atherosclerosis which often leads to cardiovascular, cerebrovascular and peripheral vascular diseases. The statins inhibit cholesterol synthesis in the body and that leads to reduction in blood cholesterol levels, which is thought to reduce the risk of atherosclerosis and diseases caused
What Are The Theosophists? What Are The Theosophists? "What Are The Theosophists?" is an editorial published in October 1879 in the theosophical magazine "The Theosophist." It was compiled by Helena Blavatsky and it was included the 2nd volume of the "Blavatsky Collected Writings." Arnold Kalnitsky wrote in his thesis that in this article "we find a rather expansive statement of... [Blavatsky's] thoughts at that moment about the status of the movement, the Theosophical Society, its objectives, and the issues it was confronting." He wrote that the article begins with a question whether the Theosophists "are they what they claim to be": researchers of the