Edward Stone (natural philosopher) piece of bark from a willow tree and was struck by its extremely bitter taste. Knowing that the bark of the Peruvian cinchona tree − from which quinine (used in the treatment of malarial fevers) is derived − has a similarly bitter taste, he surmised that the willow might also have therapeutic properties. Stone's interest in willows was due to the ancient "doctrine of signatures" – whereby the cause of a disease offers a clue to its treatment. According to Stone: "As this tree delights in a moist or wet soil, where agues chiefly abound, the general maxim that many
Cinchona knighted. For the role in establishing cinchona in Indonesia, Hasskarl was knighted with the Dutch order of the Lion. "Cinchona" species are used as food plants by the larvae of some Lepidoptera species, including the engrailed, the commander, and members of the genus "Endoclita", including "E. damor", "E. purpurescens" and "E. sericeus". "Cinchona pubescens" has grown uncontrolled on some islands such as the Galapagos where it has posed the risk of outcompeting native plant species. In herbalism, cinchona bark was used as an adulterant in Jesuit's bark or Peruvian bark which originally is thought to have referred to "Myroxylon peruiferum",