Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Drugs in Cambodia among the arrested. They were allegedly caught in possession of nearly half a kilo of methamphetamines and cocaine. The men potentially face life sentences if they are to be convicted. These recent developments and arrests only further emphasizes that Cambodia is cracking down on the drug trade which exists in the country. According to secretary-general of the National Authority to Combat Drugs they emphasized that ‘There will be further raids. We are cracking down hard on people who provide illegal drugs.’ On April 10, 2009, four drug traders and traffickers, including two Cambodian nationals were prosecuted and arrested. The four