Cinchona ledgeriana" had a yield of 8 to 13 percent quinine in bark grown in Dutch Indonesia which effectively out-competed the British Indian production. It was only later that the English saw the value and sought to obtain the seeds of "C. ledgeriana" from the Dutch. During World War II, the Japanese conquered Java and the United States lost access to the cinchona plantations that supplied war-critical quinine medication. Botanical expeditions – called Cinchona Missions – were launched in 1942-1944 to explore promising areas of South America in an effort to locate cinchona species that contained quinine and could be harvested
Jesuit's bark long conflict over the good or harm effected by Peruvian Bark". The Spanish Jesuit missionaries in Peru were taught the healing power of the bark by natives, between 1620 and 1630, when a Jesuit at Loxa was indebted to its use for his cure from an attack of malaria ("Loxa Bark"). It was used at the recommendation of the Jesuits in 1630, when the Countess of Chinchon (Cinchon; the derivative is Cinchona, the appellation selected by Carl Linnaeus in 1742; Clements Markham preferred Chinchona), wife of the new viceroy, who had just arrived from Europe, was taken ill with malaria