Edward Stone (natural philosopher) piece of bark from a willow tree and was struck by its extremely bitter taste. Knowing that the bark of the Peruvian cinchona tree − from which quinine (used in the treatment of malarial fevers) is derived − has a similarly bitter taste, he surmised that the willow might also have therapeutic properties. Stone's interest in willows was due to the ancient "doctrine of signatures" – whereby the cause of a disease offers a clue to its treatment. According to Stone: "As this tree delights in a moist or wet soil, where agues chiefly abound, the general maxim that many
Naturally aspirated engine Naturally aspirated engine A naturally aspirated engine is an internal combustion engine in which oxygen intake depends solely on atmospheric pressure and does not rely on forced induction through a turbocharger or a supercharger. Many sports cars specifically use naturally aspirated engines to avoid turbo lag. In a naturally aspirated engine, air for combustion (diesel cycle in a diesel engine or specific types of Otto cycle in petrol engines—namely petrol direct injection), or an air/fuel mixture (traditional Otto cycle petrol engines)—is drawn into the engine’s cylinders by atmospheric pressure acting against a partial vacuum that occurs as the piston travels