Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
What Degree? Which University? student life, student housing, and graduate opportunities for university leavers through the "Lifestyle", "Student Housing", "Survival Guide" and "After Uni" sections. The creator of "What Degree? Which University?" is David Handley, who is also the founding director of international sculpture exhibition, "Sculpture by the Sea". Handley first conceptualised "What Degree? Which University?" whilst studying his final year of Law at the University of Sydney. In 1988, "What Degree? Which University?" initially took form through university seminars held at the University of Sydney, allowing prospective students to compare degree options by hearing current and former students of undergraduate degree programs discuss