Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Lacing (drugs) Lacing (drugs) Lacing is the act of adding one or more substances to another. Some street drugs are commonly laced with other chemicals for various reasons, but it is most commonly done so as to bulk up the original product or to sell other, cheaper drugs in the place of something more expensive. Individuals sometimes lace their own drugs with another substance to combine or alter the physiological or psychoactive effects. Drugs may be sold to end users who are unaware they have been laced or are unaware what was used to lace them. At various points in the supply