Cinchona in the year 1851. Mr. [Thaddäus] Haenke mentioned the existence of cinchona bark on his visit to Yuracares in 1796". (Source: Exploration of the Valley of the Amazon, by Lieut. Lardner Gibbon, USN. Vol.II, Ch.6, pp. 146-47.) The cultivation of cinchona led from the 1890s to a decline in the price of quinine but the quality and production of raw bark by the Dutch in Indonesia led them to dominate world markets. The producers of processed drugs in Europe (especially Germany) however bargained and caused fluctuations in prices which led to a Dutch-led Cinchona Agreement in 1913 that ensured a
Jesuit's bark in the Jesuit College at Rome, who undoubtedly deserves the greatest credit after de Lugo for distributing the genuine unadulterated article, and to whom are attributed the Roman directions for its use "Schedula Romana", the earliest dating at least from 1651. In his friend Honoré Fabri, a French Jesuit, who stayed for a time in Rome, de Lugo won a determined defender of the bark against the first anticinchona pamphlet written by the Brussels doctor Jean-Jacques Chifflet. Under the pseudonym of Antimus Conygius, Fabri wrote in 1655 the first paper on cinchona published in Italy, as well as the first