Quinine the Quechua, who are indigenous to Peru, Bolivia and Ecuador, to halt shivering due to low temperatures. The Quechuas would mix the ground bark of cinchona trees with sweetened water to offset the bark's bitter taste, thus producing tonic water. The Jesuits were the first to bring cinchona to Europe. The Spanish were aware of the medicinal properties of cinchona bark by the 1570s or earlier: Nicolás Monardes (1571) and Juan Fragoso (1572) both described a tree that was subsequently identified as the cinchona tree and whose bark was used to produce a drink to treat diarrhea. Quinine has been
Jesuit's bark "Pulvis Patrum". The history of cinchona bark, which dates back more than 300 years, has greatly influenced that of pharmacy, botany, medicine, trade, theoretical and practical chemistry, and tropical agriculture. Circa 1650, the physician Sebastiano Bado declared that this bark had proved more precious to mankind than all the gold and silver that the Spaniards had obtained from South America, and the world confirmed his opinion. See also Swords, Ships and Sugar - The History of Nevis, by Vincent K. Hubbard, p. 73, where a large amount of "Peruvian Bark" had been captured by the pirate Basil Ringrose, also known