Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Fire in the Blood (2013 film) Fire in the Blood (2013 film) Fire in the Blood is a 2013 documentary film by Dylan Mohan Gray depicting the intentional obstruction of access to low-cost antiretroviral drugs used in the treatment of HIV/AIDS to people in Africa and other parts the global south, driven by multinational pharmaceutical companies holding patent monopolies and various Western governments (above all those of the United States, European Union and Switzerland) consistently doing these companies' bidding. The film details how the battle against this genocidal blockade, estimated to have resulted in no less than ten- to twelve million completely unnecessary deaths, was fought