Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
What Are The Theosophists? What Are The Theosophists? "What Are The Theosophists?" is an editorial published in October 1879 in the theosophical magazine "The Theosophist." It was compiled by Helena Blavatsky and it was included the 2nd volume of the "Blavatsky Collected Writings." Arnold Kalnitsky wrote in his thesis that in this article "we find a rather expansive statement of... [Blavatsky's] thoughts at that moment about the status of the movement, the Theosophical Society, its objectives, and the issues it was confronting." He wrote that the article begins with a question whether the Theosophists "are they what they claim to be": researchers of the