Discovery and development of statins trials showed very good inhibitory effect as in clinical trials, however in a long term toxicity study in dogs it resulted in toxic effects at higher doses and as a result was believed to be too toxic to be given to humans. In 1978, Alfred Alberts and colleagues at Merck Research Laboratories discovered a new natural product in a fermentation broth of "Aspergillus terreus", their product showed good HMGR inhibition and they named the product mevinolin, which later became known as lovastatin. The cholesterol controversy began in the early promotion of statins. Statins are a competitive antagonists of HMG CoA,
Drugs in Cambodia among the arrested. They were allegedly caught in possession of nearly half a kilo of methamphetamines and cocaine. The men potentially face life sentences if they are to be convicted. These recent developments and arrests only further emphasizes that Cambodia is cracking down on the drug trade which exists in the country. According to secretary-general of the National Authority to Combat Drugs they emphasized that ‘There will be further raids. We are cracking down hard on people who provide illegal drugs.’ On April 10, 2009, four drug traders and traffickers, including two Cambodian nationals were prosecuted and arrested. The four