Cinchona officinalis many-flowered; hypanthium with short coarse hairs; reddish calyx, glabrous or nearly so, with triangular lobes; pink or red corolla, sericeous, the lobes ovate, acute, the corolla tube being about 1 cm. long. Fruit and oblong capsule, 1.5–2 cm. long, almost glabrous. English: quinine, red cinchona, cinchona bark, Jesuit’s bark, loxa bark, Jesuit’s powder, countess powder, Peruvian bark. Spanish: quina, cascarilla, cargua cargua, corteza coja. French: quinquina, écorce du Pérou. "Cinchona officinalis" is a medicinal plant, one of several "Cinchona" species used for the production of quinine, which is an anti-fever agent. It is especially useful in the prevention and treatment
Analgesic tolerance, which may be of particular concern regarding patients suffering with chronic pain and requiring an analgesic over long periods. Opioid tolerance is often addressed with opioid rotation therapy in which a patient is routinely switched between two or more non-cross-tolerant opioid medications in order to prevent exceeding safe dosages in the attempt to achieve an adequate analgesic effect. Opioid tolerance should not be confused with opioid-induced hyperalgesia. The symptoms of these two conditions can appear very similar but the mechanism of action is different. Opioid-induced hyperalgesia is when exposure to opioids increases the sensation of pain (hyperalgesia) and can