Consumer Reports Best Buy Drugs category; and cost less on average than other drugs in the category. Several of the Best Buys have been chosen because of their superior effectiveness or safety profile even though they may cost more. The project publishes Best Buy Drugs drug reports, the first three such reports covered Statins to reduce high cholesterol, heartburn drugs, and NSAIDs commonly used to treat arthritis. The project covers over 20 conditions and the most widely used drugs. The reports are published in web versions, and two-page PDF summaries in English and Spanish. More than half of all prescription drugs cause adverse effects—some serious
Discovery and development of statins 2 statins. One of the main differences between the type 1 and type 2 statins is the replacement of the butyryl group of type 1 statins by the fluorophenyl group of type 2 statins. This group is responsible for additional polar interactions that causes tighter binding to the HMGR enzyme. Statins that belong to this group are: Lovastatin is derived from a fungus source and simvastatin and pravastatin are chemical modifications of lovastatin and as a result do not differ much in structure from lovastatin. All three are partially reduced napthylene ring structures. Simvastatin and lovastatin are inactive lactones which