Discovery and development of statins Discovery and development of statins The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Hypercholesterolemia is considered to be one of the major risk factors for atherosclerosis which often leads to cardiovascular, cerebrovascular and peripheral vascular diseases. The statins inhibit cholesterol synthesis in the body and that leads to reduction in blood cholesterol levels, which is thought to reduce the risk of atherosclerosis and diseases caused by it. More than 100 years ago a German pathologist named Rudolf Virchow discovered that cholesterol was to be found in the artery
Drugs in Cambodia among the arrested. They were allegedly caught in possession of nearly half a kilo of methamphetamines and cocaine. The men potentially face life sentences if they are to be convicted. These recent developments and arrests only further emphasizes that Cambodia is cracking down on the drug trade which exists in the country. According to secretary-general of the National Authority to Combat Drugs they emphasized that ‘There will be further raids. We are cracking down hard on people who provide illegal drugs.’ On April 10, 2009, four drug traders and traffickers, including two Cambodian nationals were prosecuted and arrested. The four