Cinchona pubescens Cinchona pubescens Cinchona pubescens, also known as red cinchona and quina (Quechua) ( "Cascarilla, cinchona"; "quina-do-amazonas, quineira"), is native to Central and South America. It is known as a medicinal plant for its bark's high quinine content- and has similar uses to "Cinchona officinalis" in the production of quinine, most famously used for treatment of malaria. "C. pubescens" varies from small to large in size, growing to 10 meters in height (33 ft). When cut, the bark tends to turn red. Leaves are elliptical to oblate and thin. The leaves have pubescent teeth that turn red when they are older,
Analgesic nephropathy of paracetamol into "N"-acetyl-"p"-benzoquinoneimine (NAPQI). NAPQI depletes glutathione via non-enzymatic conjugation with glutathione, a naturally occurring antioxidant. With depletion of glutathione, cells of the kidney become particularly sensitive to oxidative damage. Diagnosis is traditionally based on the clinical findings above in combination with excessive analgesic use. It is estimated that between 2 and 3 kg each of phenacetin or aspirin must be consumed before evidence of analgesic nephropathy becomes clinically apparent. Once suspected, analgesic nephropathy can be confirmed with relative accuracy using computed tomography (CT) imaging without contrast. One trial demonstrated that the appearance of papillary calcifications on CT imaging