Lanosterol synthase disease prevention and treatment (see Disease Relevance, below). Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat atherosclerosis. The widely popular statin drugs currently used to lower LDL (low-density lipoprotein) cholesterol function by inhibiting HMG-CoA reductase activity. Because this enzyme catalyzes the formation of precursors far upstream of (S)-2,3-epoxysqualene and cholesterol, statins may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of isoprenoids, coenzyme Q). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than HMG-CoA reductase, is an attractive drug target. Lanosterol synthase inhibitors are thought to
Fire in the Blood (2013 film) such fora as the United Nations headquarters in New York City and Vienna, the European Parliament in Brussels, the World Health Assembly and UNAIDS headquarters in Geneva, along with dedicated screenings for lawmakers in Washington and New Delhi, and one hosted by the Indian Ministry of External Affairs (MEA) for ambassadors and consuls accredited to India. Fire in the Blood (2013 film) Fire in the Blood is a 2013 documentary film by Dylan Mohan Gray depicting the intentional obstruction of access to low-cost antiretroviral drugs used in the treatment of HIV/AIDS to people in Africa and other parts the global