Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
We Are Drugs Are Drugs", was released for streaming on September 8, 2016. The band played the 2016 iteration of Lollapalooza to promote the EP as well. We Are Drugs We Are Drugs is a studio EP by American alternative rock band Third Eye Blind. Preceded by the release of the single "Cop vs. Phone Girl" on July 25, 2016, "We Are Drugs" was published on October 7, 2016. As early as 2012, Third Eye Blind frontman Stephan Jenkins stated that following the release of their fifth album, they would cease releasing full albums, in favor of smaller EP releases. After the band