Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Religion and drugs illegality of cannabis in many nations is evidence of persecution of Rastafari. They are not surprised that it is illegal, viewing Cannabis as a powerful substance that opens people's minds to the truth – something the Babylon system, they reason, clearly does not want. Cannabis use is contrasted with the use of alcohol and other drugs, which they feel destroy the mind. Alcoholic drinks are commonly used during Asatru blots but non-alcoholic drinks can be substituted. Religion and drugs Many religions have expressed positions on what is acceptable to consume as a means of intoxication for spiritual, pleasure, or medicinal