Quinine the Quechua, who are indigenous to Peru, Bolivia and Ecuador, to halt shivering due to low temperatures. The Quechuas would mix the ground bark of cinchona trees with sweetened water to offset the bark's bitter taste, thus producing tonic water. The Jesuits were the first to bring cinchona to Europe. The Spanish were aware of the medicinal properties of cinchona bark by the 1570s or earlier: Nicolás Monardes (1571) and Juan Fragoso (1572) both described a tree that was subsequently identified as the cinchona tree and whose bark was used to produce a drink to treat diarrhea. Quinine has been
Bark pocket Bark pocket Bark pockets can be formed by inosculation, formation of a tree fork, encapsulation of a branch, joining together of an uneven trunk, or encapsulation of another object. During inosculation, the bark trapped between the two joining trunk becomes surrounded with wood once the trunks fuse. The resulting bark pocket formed during inosculation or in a tree fork is referred to as included bark. When a branch is encapsulated, the outer bark on the branch may remain inside the wood of the tree, as the trunk widens and grows around the branch. Bark pockets can be used as an