Discovery and development of statins polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique polar interaction with the enzyme. As a result, rosuvastatin has superior binding affinity to the HMGR enzyme compared to the other statins, which is directly related to its efficiency to lower LDL cholesterol. Lipophilicity of the statins is considered to be quite important since the hepatoselectivity of the statins is related to their lipophilicity. The more lipophilic statins tend to achieve higher levels of exposure in non-hepatic tissues, while the hydrophilic statins tend to be more hepatoselective. The difference in selectivity is
We Are Drugs We Are Drugs We Are Drugs is a studio EP by American alternative rock band Third Eye Blind. Preceded by the release of the single "Cop vs. Phone Girl" on July 25, 2016, "We Are Drugs" was published on October 7, 2016. As early as 2012, Third Eye Blind frontman Stephan Jenkins stated that following the release of their fifth album, they would cease releasing full albums, in favor of smaller EP releases. After the band released their fifth album, "Dopamine", in June 2015, Jenkins stated there were five to six songs from the "Dopamine" sessions that—once he had time