Discovery and development of statins as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway. The end result is lower LDL (Low Density Lipoprotein), TG (Triglycerides) and total cholesterol levels as well as increased HDL (High Density Lipoprotein) levels in serum). The ideal statin should have the following properties: One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells
Drugs in Cambodia produced and traffickers export these drugs out of the country and or shipped throughout neighboring nations. The Ruak and Mekong rivers of these areas also influences the ease of how drugs are transported through this area. The drugs are transported through the Triangle by horse and donkey caravans to refineries where the drugs are further processed and refined to become more pure. They are then most frequently brought to the United States and other countries by couriers traveling on commercial airlines or they are smuggled into the country by shipping containers. Teng Bunma is one of the wealthiest people in