Familial hypercholesterolemia disorder in two generations simultaneously." "The use of total cholesterol alone may best discriminate between people with and without FH between the ages of 1 to 9 years." Screening of toddlers has been suggested, and results of a trial on 10,000 one-year-olds were published in 2016. Work was needed to find whether screening was cost-effective, and acceptable to families. FH is usually treated with statins. Statins act by inhibiting the enzyme hydroxymethylglutaryl CoA reductase (HMG-CoA-reductase) in the liver. In response, the liver produces more LDL receptors, which remove circulating LDL from the blood. Statins effectively lower cholesterol and LDL levels,
We Are All on Drugs was eventually released that way on early printings of the album, and on published sheet music. It was replaced on future printings (as well as on the CD single) with "I want to reach a higher plane/ where things will never be the same." An edited version of the song for MTV "We Are All in Love," changed "on drugs" to "in love" in the chorus. Patrick Wilson suggested having the edit be "We Are All on Hugs," which Cuomo thought was too "quirky." Brian Bell suggested the "in love" edit. Despite this edit the headline "WE ARE ALL ON