Cinchona pubescens hence its nickname the red quinine tree. Its flowers form in large panicles. They are pink and fragrant, while in the Galapagos they are light pink. "C. pubescens" has the widest distribution of all "Cinchona" species, with the native range spanning Costa Rica, Panama, Venezuela, Colombia, Ecuador, Peru, and Bolivia. In Ecuador it is distributed within an altitude from . It also grows well in volcanic soil with high nutrient levels. C. pubescens is a resilient species that is able to recover from even extreme damage. If the tree is felled but the stump is left, it can grow back
History of malaria shivering from cold, it was nevertheless effective for malaria. The use of the “fever tree” bark was introduced into European medicine by Jesuit missionaries (Jesuit's bark). Jesuit Bernabé de Cobo (1582–1657), who explored Mexico and Peru, is credited with taking cinchona bark to Europe. He brought the bark from Lima to Spain, and then to Rome and other parts of Italy, in 1632. Francesco Torti wrote in 1712 that only “intermittent fever” was amenable to the fever tree bark. This work finally established the specific nature of cinchona bark and brought about its general use in medicine. It would be