Cinchona ledgeriana" had a yield of 8 to 13 percent quinine in bark grown in Dutch Indonesia which effectively out-competed the British Indian production. It was only later that the English saw the value and sought to obtain the seeds of "C. ledgeriana" from the Dutch. During World War II, the Japanese conquered Java and the United States lost access to the cinchona plantations that supplied war-critical quinine medication. Botanical expeditions – called Cinchona Missions – were launched in 1942-1944 to explore promising areas of South America in an effort to locate cinchona species that contained quinine and could be harvested
Bark bread bark is the only part of a tree trunk that is actually edible, the remaining bark and wood is made up of cellulose which animals, including humans, cannot digest. The dried and ground inner bark was added in proportions like 1/4th to 1/3rd "bark flour" to the remaining grain flour. Erik Pontoppidan, the Bishop of Bergen, Norway, in the mid 18th century, recommended using elm, as it helped the often crumbly bark bread hold together better. The bark will, however, add a rather bitter taste to the bread, and give particularly white bread an unappetizing grey-green hue. Another problem is