Edward Stone (natural philosopher) piece of bark from a willow tree and was struck by its extremely bitter taste. Knowing that the bark of the Peruvian cinchona tree − from which quinine (used in the treatment of malarial fevers) is derived − has a similarly bitter taste, he surmised that the willow might also have therapeutic properties. Stone's interest in willows was due to the ancient "doctrine of signatures" – whereby the cause of a disease offers a clue to its treatment. According to Stone: "As this tree delights in a moist or wet soil, where agues chiefly abound, the general maxim that many
History of pharmacy in the United States number of programs in the history of medicine, history of pharmacy programs remain few in number in the United States. As soon as Columbus started his explorations of the Americas in the late 15th century, a European effort to find valuable medicinal plants among the flora of the New World to add to the medical canon got underway. Early New World medicines uncovered included guaiacum from the West Indies (for coughs, rheumatism and a wide variety of other uses), sassafras from Florida, copaiba from Brazil, Peru balsam and, most famously, cinchona bark from Peru, also called "Jesuit's bark" in honor