Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of the central nervous system. The disease is characterised by bilateral diffuse uveitis, with pain, redness and blurring of vision. The eye symptoms may be accompanied by a varying constellation of systemic symptoms, such as auditory (tinnitus, vertigo, and hypoacusis), neurological
Thermoregulation in humans are impermeable to sweat and thus do not facilitate heat loss through evaporation can actually contribute to heat stress. Adjusting the human body temperature downward has been used therapeutically, in particular, as a method of stabilizing a body following trauma. It has been suggested that adjusting the A1 receptor of the hypothalamus may allow humans to enter a hibernation-like state of reduced body temperature, which could be useful for applications such as long-duration space flight. Humans output from 70 watts to 870 watts, depending on the amount of physical activity undertaken. Thermoregulation in humans As in other mammals, thermoregulation in