Stomatitis IV (delayed) hypersensitivity reaction that occurs in susceptible atopic individuals when allergens penetrate the skin or mucosa. Allergens, which may be different for different individuals, combine with epithelial-derived proteins, forming haptens which bind with Langerhans cells in the mucosa, which in turn present the antigen on their surface to T lymphocytes, sensitizing them to that antigen and causing them to produce many specific clones. The second time that specific antigen is encountered, an inflammatory reaction is triggered at the site of exposure. Allergic contact stomatitis is less common than allergic contact dermatitis because the mouth is coated in saliva, which
Institute of Physics and Engineering in Medicine Institute of Physics and Engineering in Medicine The Institute of Physics and Engineering in Medicine (IPEM) is the United Kingdom's professional body and learned society for physicists, engineers and technologists within the field of medicine, founded in 1995, changing its name from the Institution of Physics and Engineering in Medicine and Biology (IPEMB) in 1997. The Institute is governed by an elected Board of Trustees reporting to which are the Science, Research and Innovation Council and the Professional and Standards Council. The councils have operational responsibility for scientific and professional aspects of the Institute's work, respectively. Beneath the councils is