Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
The Historical Conquests of Josh Ritter Ritter self-referentially uses it in the lyrics of "Empty Hearts," suggesting that the songs on the CD may have an interrelated design. In regards to "The Historical Conquests of Josh Ritter", "Paste Magazine" described Ritter as the poster-boy of Americana music. As with previous albums, Ritter was compared to the great American songwriters like Bob Dylan and Bruce Springsteen. All songs written by Josh Ritter. The strings were written and arranged by Sam Kassirer, and the horns by Sam Kassirer and Zack Hickman. Initial copies of the album included a limited-edition bonus EP CD containing "four little tracks - interesting