Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of the central nervous system. The disease is characterised by bilateral diffuse uveitis, with pain, redness and blurring of vision. The eye symptoms may be accompanied by a varying constellation of systemic symptoms, such as auditory (tinnitus, vertigo, and hypoacusis), neurological
Brown blotch disease blotch disease causes large economic losses due to a perceived decrease in quality, even though it does not cause any health problems in humans. Brown blotch disease is observed in mushroom farms all over the world. In the UK, the Netherlands and France, 15% of the crop weight is affected by brown blotch disease, while in Italy it is even worse; in the worst years, 40% of the total weight of mushroom crops is affected by brown blotch disease in Italy. Because brown blotch disease affects all mushroom species, exotic mushrooms grown in eastern countries such as Japan, China, and