Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
Coenurosis in humans the oncospheres develop into cystic like larvae balls called coenuri. The cycle perpetuates when a canid (definitive host) ingests the tissue of an infected intermediate host. When this happens, the maturing larvae reside in the small intestine of the definitive host until they mature into adult worms and begin producing eggs (which will eventually be passed through feces into the environment once again). Because this disease is so rare in humans, accurate diagnostic techniques have not been developed. CT scans and MRI’s are useful for detecting fluid filled cysts in all areas of the body, and some serological and microscopic