Stomatitis meaning "inflammation". Malnutrition (improper dietary intake) or malabsorption (poor absorption of nutrients into the body) can lead to nutritional deficiency states, several of which can lead to stomatitis. For example, deficiencies of iron, vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B6 (pyridoxine), vitamin B9 (folic acid) or vitamin B12 (cobalamine) may all manifest as stomatitis. Iron is necessary for the upregulation of transcriptional elements for cell replication and repair. Lack of iron can cause genetic downregulation of these elements, leading to ineffective repair and regeneration of epithelial cells, especially in the mouth and lips. Many disorders which cause malabsorption can
Aphthous stomatitis aphthae, (recurrent) aphthous ulceration and (oral) aphthosis. In traditional Chinese medicine, claimed treatments for aphthae focus on clearing heat and nourishing Yin. Rembrandt Gentle White toothpaste did not contain sodium lauryl sulfate, and was specifically marketed as being for the benefit of "canker sore sufferers". When the manufacturer Johnson & Johnson discontinued the product in 2014, it caused a backlash of anger from long term customers, and the toothpaste began to sell for many times the original price on the auction website eBay. Aphthous stomatitis Aphthous stomatitis is a common condition characterized by the repeated formation of benign and non-contagious