Independence of Panama from Spain Independence of Panama from Spain Independence of Panama from Spain was accomplished through a bloodless revolt between 10 November 1821 and 28 November 1821. Seizing the opportunity, when the Spanish governor left Panama to march on rebellious Ecuadorians, José de Fábrega led a push for independence. Rebels in the small town of Villa de Los Santos made the first declaration for independence and the movement quickly spread to the capital. Fearing that Spain would retake the country, the rebels quickly joined the Republic of Gran Colombia. Initial attempts to free Panama from Spain came from South American liberators, not Panamanians,
Separation of Panama from Colombia under Tomás de Herrera. After rejoining Colombia following a 13-month independence, it remained a province which saw frequent rebellious flare-ups, notably the Panama crisis of 1885, which saw the intervention of the United States Navy. During the construction of the Panama canal, the initial attempts by France to construct a sea-level canal across the isthmus were secured through treaty with Colombia; however French cost overruns and corruption in the Panama scandals led to abandonment of the Canal for a decade. During the intervening years, local separatists used the political instability of the Thousand Days' War to agitate for political separation