Mescaline Mescaline Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. It occurs naturally in the peyote cactus ("Lophophora williamsii"), the San Pedro cactus ("Echinopsis pachanoi"), the Peruvian torch ("Echinopsis peruviana"), and other members of the Cactaceae plant family. It is also found in small amounts in certain members of the Fabaceae (bean) family, including "Acacia berlandieri". However those claims concerning Acacia species have been challenged and have been unsupported in additional analysis. Peyote has been used for at least 5,700 years by Native Americans in
O-Acetylpsilocin Franz Troxler. Despite this, psilocetin remains a psychedelic compound with a limited history of use. It is theorized to be a prodrug for psilocin, as is psilocybin, which occurs naturally in most species of hallucinogenic mushrooms. This is because the aromatic acetyl moiety on the 4th position is subject to deacetylation by acidic conditions such as those found in the stomach. Psilocetin is "O"-acetylated psilocin, whereas psilocybin is "O"-phosphorylated. "O"-Acetylpsilocin can be obtained by acetylation of psilocin under alkaline or strongly acidic conditions. It is, therefore, a semi-synthetic compound. It is believed to be a prodrug of psilocin, however, speculation