Mescaline Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador. In traditional peyote preparations, the top of the cactus is cut off, leaving the large tap root along with a ring of green photosynthesizing area to grow new heads. These heads are then dried to make disc-shaped buttons. Buttons are chewed to produce the effects or soaked in water to drink. However, the taste of the cactus is bitter,
O-Acetylpsilocin Franz Troxler. Despite this, psilocetin remains a psychedelic compound with a limited history of use. It is theorized to be a prodrug for psilocin, as is psilocybin, which occurs naturally in most species of hallucinogenic mushrooms. This is because the aromatic acetyl moiety on the 4th position is subject to deacetylation by acidic conditions such as those found in the stomach. Psilocetin is "O"-acetylated psilocin, whereas psilocybin is "O"-phosphorylated. "O"-Acetylpsilocin can be obtained by acetylation of psilocin under alkaline or strongly acidic conditions. It is, therefore, a semi-synthetic compound. It is believed to be a prodrug of psilocin, however, speculation