CYB5R3 the subsequent disease manifestation have been described. The disease manifests as the accumulation of oxidized Fe+3 in humans. Type I recessive congenital methemoglobinemia (RCM) is characterized by a deficiency of the soluble isoform and manifests as the cyanosis of skin and mucous membranes. In type II, the defect affects both isoforms and thus affects more general tissues such as red blood cells, leukocytes, and all body tissues. This type is associated with mental deficiency and other neurologic symptoms, which may be because the cytochrome b5 system plays a crucial role in the desaturation of fatty acids in the body. One
John Ritter lost to Kelsey Grammer for playing the title character of "Frasier". Upon accepting his trophy, Grammer's remarks included comments made in tribute and remembrance of Ritter. Ritter's final films, "Bad Santa" and "Clifford's Really Big Movie", along with an episode of "Scrubs" (his character in this series died, as well) and "King of the Hill", were dedicated to his memory. On June 6, 2008, a mural of Ritter painted by Eloy Torrez was dedicated at Hollywood High School. In March 2010, the Thoracic Aortic Disease (TAD) Coalition, in partnership with Yasbeck and the John Ritter Foundation (JRF), announced the creation