Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
Julian Ritter in which the surreal element is dominant. The portraits are traditional and the most genuine. The drawings become very 'slick.' The large canvases, on the other hand, tend to be too personal and too involved in allegory to hold as significant statements. In 1964, Hilde had been sick for a year but refused to see a doctor. When she collapsed, Ritter insisted and doctors discovered she had cancer. She had a mastectomy and struggled for two years before succumbing to the disease. Hilde died January 22, 1966. Ritter began drinking heavily. He later said, "I became a lousy cowardly drunk