Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
Supernumerary body part considered to have lost much or all of their original function through evolution. These body parts can be classed as additional to the required functioning of the body. In human anatomy the vermiform appendix is sometimes classed as a vestigial remnant. Prosthesis is an artificial extension that replaces a body part, and cybernetics is the study of computer technology in relation to organisms which can include replacement or additional body parts. Body integrity identity disorder (BIID) is a psychiatric disorder in which a person thinks that they have one or more additional limbs than they should, despite having two arms