Anna Morandi Manzolini having been the first person to reproduce (in wax) body parts of minute portions, including capillary vessels and nerves. Her collection of wax models was known throughout Europe as "Supellex Manzoliniana" and was eagerly sought after to aid in the study of anatomy. Her work became the archetype of such models as the Vassourie collection and the creations of Dr. Auzoux made from papier mache, which were the forerunners of those used in today's schools and colleges. A collection of her models was acquired by the Medical Institute of Bologna and is housed at the Institute of Science in Bologna.
Internal medicine diagnosis and management, by careful bedside study of the natural history of diseases and their treatment. Sydenham eschewed dissection of corpses and scrutiny of the internal workings of the body, for considering the internal mechanisms and causes of symptoms. It was thus subsequent to the 17th century that there was a rise in anatomical pathology and laboratory studies, with Giovanni Battista Morgagni, an Italian anatomist of the 18th century, being considered the father of anatomical pathology. Laboratory investigations became increasingly significant, with contribution of doctors including German physician and bacteriologist Robert Koch in the 19th century. The 19th century saw