Mescaline Mescaline Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. It occurs naturally in the peyote cactus ("Lophophora williamsii"), the San Pedro cactus ("Echinopsis pachanoi"), the Peruvian torch ("Echinopsis peruviana"), and other members of the Cactaceae plant family. It is also found in small amounts in certain members of the Fabaceae (bean) family, including "Acacia berlandieri". However those claims concerning Acacia species have been challenged and have been unsupported in additional analysis. Peyote has been used for at least 5,700 years by Native Americans in
NBOMe-mescaline NBOMe-mescaline NBOMe-mescaline or mescaline-NBOMe is a synthetic substituted phenethylamine. It is a partial agonist of serotonin receptors with a 5-HT pKi originally reported as 7.3 (i.e. Ki of approximately 50nM), though more modern techniques assayed it as 140nM at 5-HT and 640nM at 5-HT, making it one of the least potent compounds among the n-benzyl phenethylamines. NBOMe-mescaline and NBOMe-escaline were first reported in 1999 resulting from research performed at Free University of Berlin concerning their activity as partial agonists at rat vascular 5-HT2A receptors. NBOMe-mescaline was first reported in September 2008 to have been self administered by humans as a