Giovanni Manzolini to become a figure painter, Manzolini joined Ercole Lelli's studio at the age of 40 to learn the art of anatomical sculpture. He was made Lelli's assistant in 1743. Under Lelli, Manzolini was made chief assistant on the papal commission to make wax models for the Anatomy Museum of the Academy of Sciences of Bologna Institute, holding this position for three years. He resigned in late 1746. He felt bitterly that Lelli had deprived him of recognition for his greater knowledge of anatomy and anatomical sculpture. After leaving Lelli, Manzolini opened his own studio for wax modelling and launched a
Anna Morandi Manzolini as well as other royal courts. It became her major turning point in her life. In order to learn anatomy, she had to dissect cadavers, which was extremely difficult for her, but she overcame her fears. Giovanni Manzolini was so encouraged by her and her accomplishments that he again returned to his work. They were recognized as a team by many artists, intellectuals, and anatomists in Europe. After her husband's death, she was appointed Lecturer in Anatomy in her own name by the Institute of Bologna. Anna partnered with her husband, and then surpassed him in skill after his death