Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
John Ritter lost to Kelsey Grammer for playing the title character of "Frasier". Upon accepting his trophy, Grammer's remarks included comments made in tribute and remembrance of Ritter. Ritter's final films, "Bad Santa" and "Clifford's Really Big Movie", along with an episode of "Scrubs" (his character in this series died, as well) and "King of the Hill", were dedicated to his memory. On June 6, 2008, a mural of Ritter painted by Eloy Torrez was dedicated at Hollywood High School. In March 2010, the Thoracic Aortic Disease (TAD) Coalition, in partnership with Yasbeck and the John Ritter Foundation (JRF), announced the creation