Aphthous stomatitis caused by a reduction in numbers of CD4+ T cells may be implicated in RAS-type ulceration in HIV infection. The thickness of the mucosa may be an important factor in aphthous stomatitis. Usually, ulcers form on the thinner, non-keratinizing mucosal surfaces in the mouth. Factors which decrease the thickness of the mucosa increase the frequency of occurrence, and factors which increase the thickness of the mucosa correlate with decreased ulceration. The nutritional deficiencies associated with aphthous stomatitis (Vitamin B12, folate, and iron) can all cause a decrease in the thickness of the oral mucosa (atrophy). Local trauma is also associated
Institute of Physics and Engineering in Medicine Institute of Physics and Engineering in Medicine The Institute of Physics and Engineering in Medicine (IPEM) is the United Kingdom's professional body and learned society for physicists, engineers and technologists within the field of medicine, founded in 1995, changing its name from the Institution of Physics and Engineering in Medicine and Biology (IPEMB) in 1997. The Institute is governed by an elected Board of Trustees reporting to which are the Science, Research and Innovation Council and the Professional and Standards Council. The councils have operational responsibility for scientific and professional aspects of the Institute's work, respectively. Beneath the councils is