Vogt–Koyanagi–Harada disease at the University of Tokyo, in 1911. It was the much later article, published in 1929, that definitively associated Koyanagi with the disease. Harada's 1926 paper is recognized for its comprehensive description of what is now known as Vogt–Koyanagi–Harada disease. Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of
Influx of disease in the Caribbean disruption and epidemic diseases such as smallpox and measles (to which they had no natural immunity) led to a decline in the Amerindian population. From 1500 to 1800 the population rose as slaves arrived from West Africa such as the Kongo, Igbo, Akan, Fon and Yoruba. Malaria was spread by the "Anopheles" mosquito and yellow fever was spread by the "Aedes aegypti" mosquito. Mosquitoes would ingest blood from one human who was a carrier of the disease and pass the virus to another human. The presence of mosquitos to act as a vector, combined with a reservoir of infected humans,