CYB5R3 the subsequent disease manifestation have been described. The disease manifests as the accumulation of oxidized Fe+3 in humans. Type I recessive congenital methemoglobinemia (RCM) is characterized by a deficiency of the soluble isoform and manifests as the cyanosis of skin and mucous membranes. In type II, the defect affects both isoforms and thus affects more general tissues such as red blood cells, leukocytes, and all body tissues. This type is associated with mental deficiency and other neurologic symptoms, which may be because the cytochrome b5 system plays a crucial role in the desaturation of fatty acids in the body. One
Inclusion body disease Inclusion body disease Inclusion body disease (IBD) is an infectious and invariably fatal viral disease affecting captive specimens of the boid family of snakes, particularly "Boa constrictor". It has been recognized since the mid-1970s. It is so named because of the characteristic intracytoplasmic inclusions which are observed in clinical examinations in epidermal cells, oral mucosal epithelial cells, visceral epithelial cells, and neurons. In the 1970s and 1980s, the disease was most commonly observed in Burmese pythons ("Python bivittatus"). From the 1980s till the present day, it has been most commonly observed in boa constrictors. To date, no treatment for IBD