Stomatitis IV (delayed) hypersensitivity reaction that occurs in susceptible atopic individuals when allergens penetrate the skin or mucosa. Allergens, which may be different for different individuals, combine with epithelial-derived proteins, forming haptens which bind with Langerhans cells in the mucosa, which in turn present the antigen on their surface to T lymphocytes, sensitizing them to that antigen and causing them to produce many specific clones. The second time that specific antigen is encountered, an inflammatory reaction is triggered at the site of exposure. Allergic contact stomatitis is less common than allergic contact dermatitis because the mouth is coated in saliva, which
Aphthous stomatitis aphthae, (recurrent) aphthous ulceration and (oral) aphthosis. In traditional Chinese medicine, claimed treatments for aphthae focus on clearing heat and nourishing Yin. Rembrandt Gentle White toothpaste did not contain sodium lauryl sulfate, and was specifically marketed as being for the benefit of "canker sore sufferers". When the manufacturer Johnson & Johnson discontinued the product in 2014, it caused a backlash of anger from long term customers, and the toothpaste began to sell for many times the original price on the auction website eBay. Aphthous stomatitis Aphthous stomatitis is a common condition characterized by the repeated formation of benign and non-contagious