Wilson's disease liver. It is due to mutations in the "COMMD1" (or "MURR1") gene. Despite this findings, "COMMD1" mutations could not be detected in humans with non-Wilsonian copper accumulation states (such as Indian childhood cirrhosis) to explain their genetic origin. Wilson's disease Wilson's disease is a genetic disorder in which copper builds up in the body. Symptoms are typically related to the brain and liver. Liver related symptoms include vomiting, weakness, fluid build up in the abdomen, swelling of the legs, yellowish skin, and itchiness. Brain related symptoms include tremors, muscle stiffness, trouble speaking, personality changes, anxiety, and seeing or hearing things
Brown blotch disease blotch disease causes large economic losses due to a perceived decrease in quality, even though it does not cause any health problems in humans. Brown blotch disease is observed in mushroom farms all over the world. In the UK, the Netherlands and France, 15% of the crop weight is affected by brown blotch disease, while in Italy it is even worse; in the worst years, 40% of the total weight of mushroom crops is affected by brown blotch disease in Italy. Because brown blotch disease affects all mushroom species, exotic mushrooms grown in eastern countries such as Japan, China, and