Wilson's disease liver. It is due to mutations in the "COMMD1" (or "MURR1") gene. Despite this findings, "COMMD1" mutations could not be detected in humans with non-Wilsonian copper accumulation states (such as Indian childhood cirrhosis) to explain their genetic origin. Wilson's disease Wilson's disease is a genetic disorder in which copper builds up in the body. Symptoms are typically related to the brain and liver. Liver related symptoms include vomiting, weakness, fluid build up in the abdomen, swelling of the legs, yellowish skin, and itchiness. Brain related symptoms include tremors, muscle stiffness, trouble speaking, personality changes, anxiety, and seeing or hearing things
Motor neuron disease Motor neuron disease Motor neuron diseases (MNDs) are a group of neurodegenerative disorders that selectively affect motor neurons, the cells which control voluntary muscles of the body. Commonly, the following disorders are counted among motor neuron diseases: The term “motor neuron disease” sometimes refers to ALS, but in this article, the term refers to a group of diseases listed above, which includes ALS. Motor neuron diseases affect both children and adults. While each motor neuron disease affects patients differently, they all cause movement-related symptoms, mainly muscle weakness. Most diseases seem to occur randomly without known causes, but some forms are