Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
Thermoregulation in humans are impermeable to sweat and thus do not facilitate heat loss through evaporation can actually contribute to heat stress. Adjusting the human body temperature downward has been used therapeutically, in particular, as a method of stabilizing a body following trauma. It has been suggested that adjusting the A1 receptor of the hypothalamus may allow humans to enter a hibernation-like state of reduced body temperature, which could be useful for applications such as long-duration space flight. Humans output from 70 watts to 870 watts, depending on the amount of physical activity undertaken. Thermoregulation in humans As in other mammals, thermoregulation in