Vogt–Koyanagi–Harada disease at the University of Tokyo, in 1911. It was the much later article, published in 1929, that definitively associated Koyanagi with the disease. Harada's 1926 paper is recognized for its comprehensive description of what is now known as Vogt–Koyanagi–Harada disease. Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of
Neoteny in humans while relinquishing others. For example, the high leg-to-body ratio (long legs) of adult humans as opposed to human infants shows that there is not a holistic trend in humans towards neoteny when compared to the other great apes. Andrew Arthur Abbie agrees, citing the gerontomorphic fleshy human nose and long human legs as contradicting the neoteny hominid evolution hypothesis, although he does believe humans are generally neotenous. Brian K. Hall also cites the long legs of humans as a peramorphic trait, which is in sharp contrast to neoteny. On the balance, an all or nothing approach could be regarded as