Anna Morandi Manzolini in 1755 in the scientific knowledge of human anatomy as well as the accurate demonstration of anatomy in wax sculpture. During her famed household lectures on anatomy given before medical practitioners and grand tourists alike, she imparted expert knowledge of empirical anatomy derived from the dissection of, by her own account, of more than 1,000 cadavers, as well as of anatomical discoveries the couple and she alone made. She clearly demonstrated, both theoretically and practically, the wonderful structure of the human body. She also crafted two portrait busts in wax, both of which are currently on display at the Palazzo
Anna Morandi Manzolini as well as other royal courts. It became her major turning point in her life. In order to learn anatomy, she had to dissect cadavers, which was extremely difficult for her, but she overcame her fears. Giovanni Manzolini was so encouraged by her and her accomplishments that he again returned to his work. They were recognized as a team by many artists, intellectuals, and anatomists in Europe. After her husband's death, she was appointed Lecturer in Anatomy in her own name by the Institute of Bologna. Anna partnered with her husband, and then surpassed him in skill after his death