Dermatophyllum secundiflorum Dermatophyllum secundiflorum Dermatophyllum secundiflorum is a species of flowering shrub or small tree in the pea family, Fabaceae, that is native to the southwestern United States (Texas, New Mexico) and Mexico (Chihuahua and Coahuila south to Hidalgo, Puebla and Querétaro). Common names include Texas mountain laurel, Texas mescalbean, frijolito, and frijolillo. Although "mescalbean" is among the plant's common appellations, it bears no relation to the "Agave" species used to make the spirit mezcal, nor to the peyote cactus ("Lophophora williamsii"), which contains the hallucinogenic alkaloid mescaline. It is well-adapted to arid and semi-arid habitats but is most common in riparian
Mescaline and activates the serotonin 5-HT receptor with a high affinity. How activating the 5-HT receptor leads to psychedelia is still unknown, but it is likely that somehow it involves excitation of neurons in the prefrontal cortex. Mescaline is also known to bind to and activate the serotonin 5-HT receptor. Difluoromescaline and trifluoromescaline are more potent than mescaline, as is its amphetamine homologue trimethoxyamphetamine. In the United States, mescaline was made illegal in 1970 by the Comprehensive Drug Abuse Prevention and Control Act, categorized as a Schedule I hallucinogen. The drug was prohibited internationally by the 1971 Convention on Psychotropic Substances.