Anna Morandi Manzolini having been the first person to reproduce (in wax) body parts of minute portions, including capillary vessels and nerves. Her collection of wax models was known throughout Europe as "Supellex Manzoliniana" and was eagerly sought after to aid in the study of anatomy. Her work became the archetype of such models as the Vassourie collection and the creations of Dr. Auzoux made from papier mache, which were the forerunners of those used in today's schools and colleges. A collection of her models was acquired by the Medical Institute of Bologna and is housed at the Institute of Science in Bologna.
18th century and the classical period (including Joseph Haydn and Wolfgang Amadeus Mozart). The 18th century also marked the end of the Polish–Lithuanian Commonwealth as an independent state. The once-powerful and vast kingdom, which had once conquered Moscow and defeated great Ottoman armies, collapsed under numerous invasions. Its semi-democratic government system was not robust enough to rival the neighboring monarchies of the Kingdom of Prussia, the Russian Empire and the Austrian Empire which divided the Commonwealth territories between themselves, changing the landscape of Central European politics for the next hundred years. European colonization of the Americas and other parts of the world