CYB5R3 the subsequent disease manifestation have been described. The disease manifests as the accumulation of oxidized Fe+3 in humans. Type I recessive congenital methemoglobinemia (RCM) is characterized by a deficiency of the soluble isoform and manifests as the cyanosis of skin and mucous membranes. In type II, the defect affects both isoforms and thus affects more general tissues such as red blood cells, leukocytes, and all body tissues. This type is associated with mental deficiency and other neurologic symptoms, which may be because the cytochrome b5 system plays a crucial role in the desaturation of fatty acids in the body. One
Influx of disease in the Caribbean disruption and epidemic diseases such as smallpox and measles (to which they had no natural immunity) led to a decline in the Amerindian population. From 1500 to 1800 the population rose as slaves arrived from West Africa such as the Kongo, Igbo, Akan, Fon and Yoruba. Malaria was spread by the "Anopheles" mosquito and yellow fever was spread by the "Aedes aegypti" mosquito. Mosquitoes would ingest blood from one human who was a carrier of the disease and pass the virus to another human. The presence of mosquitos to act as a vector, combined with a reservoir of infected humans,