Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
Cardiovascular disease in Australia Cardiovascular disease in Australia Cardiovascular disease, including heart disease, is a major cause of death in Australia. Heart disease is an overall term used for any type of Cardiovascular disease that affects the heart reducing blood supply to the heart. It is also often referred as Cardiac disease and Coronary heart disease. It is generally a lifelong condition where damage to the artery and blood vessel cannot be cured. Cardiovascular disease (CVD) continues to have a major impact on the health of Australians in terms of prevalence, mortality, morbidity, burden of disease and expenditure. From 2007-08, an estimated 3.4 million