Denture-related stomatitis erythematous (red) and edematous (swollen), sometimes with petechial hemorrhage (pin-points of bleeding). This usually occurs beneath an upper denture. Sometimes angular cheilitis can coexist, which is inflammation of the corners of the mouth, also often associated with "Candida albicans". Stomatitis rarely develops under a lower denture. The affected mucosa is often sharply defined, in the shape of the covering denture. The major risk factor for the development of this condition is wearing an upper complete denture, particularly when it is not removed during sleep and cleaned regularly. Older dentures are more likely to be involved. Other factors include xerostomia (dry
Systems medicine Systems medicine Systems medicine is an interdisciplinary field of study that looks at the systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems medicine draws on systems science and systems biology, and considers complex interactions within the human body in light of a patient's genomics, behavior and environment. The earliest uses of the term "systems medicine" appeared in 1992, in an article on systems medicine and pharmacology by B.J. Zeng and in a paper on systems biomedicine by T. Kamada. An important topic in systems medicine and systems biomedicine is the