Soap bubble into college years. A Swiss university professor, Dr. Natalie Hartzell, has theorized that usage of artificial bubbles for entertainment purposes of young children has shown a positive effect in the region of the child's brain that controls motor skills and is responsible for coordination with children exposed to bubbles at a young age showing measurably better motion skills than those who were not. Soap bubbles have been used as entertainment for at least 400 years, as evidenced by 17th-century Flemish paintings showing children blowing bubbles with clay pipes. The London-based firm A. & F. Pears created a famous advertising campaign
Autumn Leaves (painting) in "The Princess" (1847) may have influenced him: The apple held by the youngest girl at the right may allude to the loss of childhood innocence implied by reference to original sin and the expulsion from the Garden of Eden. After a positive review from F.G. Stephens, Millais wrote to him that he had "intended the picture to awaken by its solemnity the deepest religious reflection. I chose the subject of burning leaves as most calculated to produce this feeling." Autumn Leaves (painting) Autumn Leaves (1856) is a painting by John Everett Millais exhibited at the Royal Academy in 1856.