Anatomical machines Anatomical machines The anatomical machines (Italian: "macchine anatomiche") are a couple of anatomical models reproducing the human circulatory system, exposed in the Cappella Sansevero in Naples. Realised in the second half of the 18th century, they are built on top of a couple of human skeletons, a male and a female. The reproduction of the vessel system was realised with metal wire, wax and silk, but because of its richness in details, for a long time it was believed that it was of natural origin instead. The models were commissioned by Raimondo di Sangro, prince of Sansevero, and realised by
Internal medicine diagnosis and management, by careful bedside study of the natural history of diseases and their treatment. Sydenham eschewed dissection of corpses and scrutiny of the internal workings of the body, for considering the internal mechanisms and causes of symptoms. It was thus subsequent to the 17th century that there was a rise in anatomical pathology and laboratory studies, with Giovanni Battista Morgagni, an Italian anatomist of the 18th century, being considered the father of anatomical pathology. Laboratory investigations became increasingly significant, with contribution of doctors including German physician and bacteriologist Robert Koch in the 19th century. The 19th century saw