Bovine papular stomatitis humans. Bovine papular stomatitis Bovine papular stomatitis is a disease caused by a virus of the family "Poxviridae" and the genus "Parapoxvirus". It occurs worldwide in cattle. Symptoms include reddish, raised, sometimes ulcerative lesions on the lips, muzzle, and in the mouth. It usually occurs before the age of two years. Reinfection is possible because of the short duration of immunity. Clinically, the disease is mild, but its importance lies in the need to differentiate it from foot-and-mouth disease. There have been reports of both lesions on the hands of milkers and similar infections in sheep and goats, as well
Aphthous stomatitis T cells. Persons with aphthous stomatitis also have circulating lymphocytes which react with peptides 91–105 of heat shock protein 65–60, and the ratio of CD4+ T cells to CD8+ T cells in the peripheral blood of individuals with aphthous stomatitis is decreased. Aphthous stomatitis has been associated with other autoimmune diseases, namely systemic lupus erythematosus and inflammatory bowel diseases. However, common autoantibodies are not detected in most patients, and the condition tends to resolve spontaneously with advancing age rather than worsen. Evidence for the T cell-mediated mechanism of mucosal destruction is strong, but the exact triggers for this process are