Aphthous stomatitis century BC), although it seems likely that this was oral ulceration as a manifestation of some infectious disease, since they are described as occurring in epidemic-like patterns, with concurrent symptoms such as fever. Aphthous stomatitis was once thought to be a form of recurrent herpes simplex virus infection, and some clinicians still refer to the condition as "herpes" despite this cause having been disproven. The informal term "canker sore" is sometimes used, mainly in North America, either to describe this condition generally, or to refer to the individual ulcers of this condition, or mouth ulcers of any cause unrelated to
History of medicine in the Philippines Rodrigo de San Miguel's "Manual de Medicina Domestica" (Manual on Domestic Medicine), and Fr. Manuel Vilches' "Manuel del Mediquillo Visaya" (Manuel of the Visayan Traditional Healers). Philippine National Artist and painter Carlos "Botong" V. Francisco recorded and depicted the history of medicine in the Philippines by creating four mural-like four-panel oil paintings collectively titled "The Progress of Medicine in the Philippines", which traced the practice of medicine from the times of the "babaylans" ("medicine men and women") up to a period in the modern-day era. The first painting depicts pre-colonial medicine, the second portrays medicine during the Spanish colonial period,