Adult polyglucosan body disease body disease do not have identified mutations in the "GBE1" gene. In these individuals, the cause of the disease is unknown. Along with evaluation of the symptoms and a neurological examination, a diagnosis can be made based on genetic testing. Whether or not a person is making sufficient amounts of functional glycogen branching enzyme can be determined by taking a skin biopsy and testing for activity of the enzyme. Examination of tissue biopsied from the sural nerve under a microscope can reveal the presence of polyglucosan bodies. There will also be white matter changes visible in a magnetic resonance imaging
Influx of disease in the Caribbean disruption and epidemic diseases such as smallpox and measles (to which they had no natural immunity) led to a decline in the Amerindian population. From 1500 to 1800 the population rose as slaves arrived from West Africa such as the Kongo, Igbo, Akan, Fon and Yoruba. Malaria was spread by the "Anopheles" mosquito and yellow fever was spread by the "Aedes aegypti" mosquito. Mosquitoes would ingest blood from one human who was a carrier of the disease and pass the virus to another human. The presence of mosquitos to act as a vector, combined with a reservoir of infected humans,