CYB5R3 the subsequent disease manifestation have been described. The disease manifests as the accumulation of oxidized Fe+3 in humans. Type I recessive congenital methemoglobinemia (RCM) is characterized by a deficiency of the soluble isoform and manifests as the cyanosis of skin and mucous membranes. In type II, the defect affects both isoforms and thus affects more general tissues such as red blood cells, leukocytes, and all body tissues. This type is associated with mental deficiency and other neurologic symptoms, which may be because the cytochrome b5 system plays a crucial role in the desaturation of fatty acids in the body. One
John Ritter known as a coloboma in his right eye. His father, Tex Ritter, was a singing cowboy/matinee star, and his mother, Dorothy Fay (née Southworth), was an actress. He had an older brother, Thomas Matthews "Tom" (born January 8, 1947). Ritter attended Hollywood High School, where he was student body president. He attended the University of Southern California and majored in psychology with plans to have a career in politics. He later changed his major to theater arts and attended the USC School of Dramatic Arts (formerly School of Theatre). Ritter was a member of Phi Gamma Delta fraternity at USC.