Aphthous stomatitis near to the ulcer, described histologically as "perivascular cuffing". Aphthous stomatitis has been classified as a type of non-infectious stomatitis (inflammation of the mouth). One classification distinguishes "common simple aphthae", accounting for 95% of cases, with 3–6 attacks per year, rapid healing, minimal pain and restriction of ulceration to the mouth; and "complex aphthae", accounting for 5% of cases, where ulcers may be present on the genital mucosa in addition to mouth, healing is slower and pain is more severe. A more common method of classifying aphthous stomatitis is into three variants, distinguished by the size, number and location of
Systems medicine Systems medicine Systems medicine is an interdisciplinary field of study that looks at the systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems medicine draws on systems science and systems biology, and considers complex interactions within the human body in light of a patient's genomics, behavior and environment. The earliest uses of the term "systems medicine" appeared in 1992, in an article on systems medicine and pharmacology by B.J. Zeng and in a paper on systems biomedicine by T. Kamada. An important topic in systems medicine and systems biomedicine is the