Dermatophyllum secundiflorum Dermatophyllum secundiflorum Dermatophyllum secundiflorum is a species of flowering shrub or small tree in the pea family, Fabaceae, that is native to the southwestern United States (Texas, New Mexico) and Mexico (Chihuahua and Coahuila south to Hidalgo, Puebla and Querétaro). Common names include Texas mountain laurel, Texas mescalbean, frijolito, and frijolillo. Although "mescalbean" is among the plant's common appellations, it bears no relation to the "Agave" species used to make the spirit mezcal, nor to the peyote cactus ("Lophophora williamsii"), which contains the hallucinogenic alkaloid mescaline. It is well-adapted to arid and semi-arid habitats but is most common in riparian
DNA damage (naturally occurring) or via environmental factors. The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage. Damage to DNA that occurs naturally can result from metabolic or hydrolytic processes. Metabolism releases compounds that damage DNA including reactive oxygen species, reactive nitrogen species, reactive carbonyl species, lipid peroxidation products and alkylating agents, among others, while hydrolysis cleaves chemical bonds in DNA. Naturally occurring oxidative DNA damages arise at least 10,000 times per cell per day in humans and 50,000 times or more per cell per day in rats,