Stomatitis IV (delayed) hypersensitivity reaction that occurs in susceptible atopic individuals when allergens penetrate the skin or mucosa. Allergens, which may be different for different individuals, combine with epithelial-derived proteins, forming haptens which bind with Langerhans cells in the mucosa, which in turn present the antigen on their surface to T lymphocytes, sensitizing them to that antigen and causing them to produce many specific clones. The second time that specific antigen is encountered, an inflammatory reaction is triggered at the site of exposure. Allergic contact stomatitis is less common than allergic contact dermatitis because the mouth is coated in saliva, which
History of medicine in the Philippines Rodrigo de San Miguel's "Manual de Medicina Domestica" (Manual on Domestic Medicine), and Fr. Manuel Vilches' "Manuel del Mediquillo Visaya" (Manuel of the Visayan Traditional Healers). Philippine National Artist and painter Carlos "Botong" V. Francisco recorded and depicted the history of medicine in the Philippines by creating four mural-like four-panel oil paintings collectively titled "The Progress of Medicine in the Philippines", which traced the practice of medicine from the times of the "babaylans" ("medicine men and women") up to a period in the modern-day era. The first painting depicts pre-colonial medicine, the second portrays medicine during the Spanish colonial period,