Discovery and development of direct Xa inhibitors Xa was identified as a promising target for the development of new anticoagulants in the early 1980s. In 1987 the first factor Xa inhibitor, the naturally occurring compound antistasin, was isolated from the salivary glands of the Mexican leech "Haementeria officinalis". Antistasin is a polypeptide and a potent Xa inhibitor. In 1990 another naturally occurring Xa inhibitor was isolated, tick anticoagulant peptide (TAP) from extracts of the tick "Ornithodoros moubata". TAP and antistasin were used to estimate factor Xa as a drug target. Blood coagulation is a complex process by which the blood forms clots. It is an essential part
Salivary diagnostics screen for multiple agents simultaneously contributing in determining the scope of toxin exposure, thereby providing a quicker fight and diagnosis in the event of pandemic, epidemic and bioterrorism. Salivary diagnostics Salivary diagnostics or Salivaomics is a procedure for testing and maintaining the data for diagnostic purposes. Saliva based hand-held sensors are used to detect and measure proteins and nucleic acids that are present in saliva for diagnosis. Salivary diagnostic technology is showing promise in the detection and monitoring malignancies at early stage and other various health concerns. The advantages of salivary diagnostics includes ease of collection, elimination of fear of