Bivalirudin Bivalirudin Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a direct thrombin inhibitor (DTI). Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech "Hirudo medicinalis"). Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide. It is a potent and highly specific inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. Bivalirudin has a quick onset of action and a short half-life. It does not bind
Creatures 2 near the oceans. Scattered throughout the world are various seed launchers, which can be used to replenish stocks if any life-forms become extinct. Albia also has four seasons: Spring, Summer, Winter and Autumn, and boasts its very own climate, with weather such as snow mainly occurring during the colder months, and rain mostly during the Spring. The game also has an on-screen thermometer, allowing the player to monitor Albia's temperature at all times. Creatures 2's release was widely anticipated. It is likely that around 450,000 copies of the original Creatures had been sold by the time the game was released,