Legacy-free PC Legacy-free PC A legacy-free PC is a type of personal computer that lacks a floppy drive, legacy ports, and an Industry Standard Architecture (ISA) bus (or sometimes, any internal expansion bus at all). According to Microsoft, "The basic goal for these requirements is that the operating system, devices, and end users cannot detect the presence of the following: ISA slots or devices; legacy floppy disk controller (FDC); and PS/2, serial, parallel, and game ports." The legacy ports are usually replaced with Universal Serial Bus (USB) ports. A USB adapter may be used if an older device must be connected to
Serial passage found. Notice that relatively few passages are necessary to produce a noticeable change in a virus; for instance, a virus can typically adapt to a new host within ten or so passages. In fact, exactly because serial passage allows for rapid evolution of a virus to its host, it can be used to study the evolution of antibiotic resistance; specifically, for determining what mutations could lead to the development of antibiotic resistance. The technique of serial passage has been around since the 1800s. In particular, Louis Pasteur’s work with the rabies vaccine in the late 1800s exemplifies this method. Pasteur