Pennsylvania Avenue National Historic Site in American history have occurred within the boundaries of the Pennsylvania Avenue National Historic Site. Pennsylvania Avenue in particular is the focal point for a great many politically important parades and protests. A number of these historic events have been assassinations or funerals. President Abraham Lincoln was assassinated at Ford's Theatre in 1865. President James A. Garfield was shot in the Baltimore & Potomac Railroad Passenger Terminal on July 2, 1881, by Charles J. Guiteau; he died 79 days later on September 19. Prior to its designation as a historic site, six presidential funeral processions had traversed Pennsylvania Avenue, the
Charles J. Guiteau storage by the museum. Parts of Guiteau's brain remain on display in a jar at the Mütter Museum in Philadelphia. Dr. Allan McLane Hamilton said in 1881 that he believed that Guiteau was sane when he assassinated Garfield. An autopsy of Guiteau's brain revealed that his dura mater was abnormally thick, suggesting he may have had neurosyphillis, a disease which causes mental instability; he could have contracted the disease from a prostitute. George Paulson, formerly the chair of neurology at Ohio State University, disputed the neurosyphillis diagnosis, arguing that Guiteau suffered from both schizophrenia and "grandiose narcissism". In 2014, the