Hirpini reason we can't fix the exact period when the Romans subjugated them, but it must have been before 268 BC, when the Romans established their colony at Beneventum, a position that likely was the military key to the possession of their country. In the Second Punic War, the Hirpini appear as an independent people, acting apart from the rest of the Samnites. Livy expressly uses the name of Samnium in contradistinction to the land of the Hirpini. The latter people was one of those that declared in favour of Hannibal immediately after the battle of Cannae, 216 BC; but the
Ordona economic decline began during the 4th Century BC. The construction of defensive walls during this period suggests a period of battles with other centres in the region, probably comprising clashes with the Greek Hegemonic Cities in the territory, among them neighbouring Taranto. It passed over to the Romans, with the rest of Apulia, after the wars of the Greek-Messapian League, commanded by King Pirro of Epiro (280-275 BC). Herdonia was a protagonist during the Second Punic War (219-202 BC) and in particular, during the events linked to the war's most famous battle at Cannae on 2 August 216 BC. According