Discovery and development of direct Xa inhibitors Xa was identified as a promising target for the development of new anticoagulants in the early 1980s. In 1987 the first factor Xa inhibitor, the naturally occurring compound antistasin, was isolated from the salivary glands of the Mexican leech "Haementeria officinalis". Antistasin is a polypeptide and a potent Xa inhibitor. In 1990 another naturally occurring Xa inhibitor was isolated, tick anticoagulant peptide (TAP) from extracts of the tick "Ornithodoros moubata". TAP and antistasin were used to estimate factor Xa as a drug target. Blood coagulation is a complex process by which the blood forms clots. It is an essential part
The Glands with Yo La Tengo. Ross Shapiro, singer, guitarist, and founding member of The Glands, died in March 2016 following a battle with an illness. The Glands The Glands were an American indie rock band from Athens, Georgia, United States. Their first CD, "Double Thriller", was self-released in 1996 and reissued on Bar/None Records in 1998. Their self-titled album was first released in 2000 on Capricorn Records and reissued on Velocette Records in August 2001. The Glands' unique sounds recalled a variety of influences, including the Kinks, the Who, and The Rolling Stones. The song "Livin' Was Easy" was featured in