Second Punic War in 217. Moving to southern Italy in 216, Hannibal at Cannae annihilated the largest army the Romans had ever assembled. After the death or imprisonment of 130,000 Roman troops in two years, 40% of Rome's Italian allies defected to Carthage, giving her control over most of southern Italy. Macedon and Syracuse joined the Carthaginian side after Cannae and the conflict spread to Greece and Sicily. From 215–210 the Carthaginian army and navy launched repeated amphibious assaults to capture Roman Sicily and Sardinia but were ultimately repulsed. Against Hannibal's skill on the battlefield, the Romans adopted the Fabian strategy – the
Romans in Persia of the dynasties in control of their empires in different historical periods: first were the Medians (Media Atropatene), then Parthians and finally Sassanians. In 64 BC Pompey conquered the remaining Seleucid territories in Syria, extinguishing their state and advancing the Roman eastern frontier to the Euphrates, where Romans met for the first time the territory of the Parthians. Mark Antony, in his quest to avenge the battle of Carrhae defeat, conquered in 33 BC some areas of Atropatene (northern Iran) and Armenia but soon lost it: that was the first time that Romans occupied a Persian territory, even if temporarily.