Second Punic War in 217. Moving to southern Italy in 216, Hannibal at Cannae annihilated the largest army the Romans had ever assembled. After the death or imprisonment of 130,000 Roman troops in two years, 40% of Rome's Italian allies defected to Carthage, giving her control over most of southern Italy. Macedon and Syracuse joined the Carthaginian side after Cannae and the conflict spread to Greece and Sicily. From 215–210 the Carthaginian army and navy launched repeated amphibious assaults to capture Roman Sicily and Sardinia but were ultimately repulsed. Against Hannibal's skill on the battlefield, the Romans adopted the Fabian strategy – the
History of general anesthesia History of general anesthesia Attempts at producing a state of general anesthesia can be traced throughout recorded history in the writings of the ancient Sumerians, Babylonians, Assyrians, Egyptians, Greeks, Romans, Indians, and Chinese. During the Middle Ages, which correspond roughly to what is sometimes referred to as the Islamic Golden Age, scientists and other scholars made significant advances in science and medicine in the Muslim world and Eastern world. The Renaissance saw significant advances in anatomy and surgical technique. However, despite all this progress, surgery remained a treatment of last resort. Largely because of the associated pain, many patients with