Discovery and development of direct thrombin inhibitors the binding site for the globular amino-terminal domain and exosite 1 is the binding site for the acidic carboxy-terminal domain of hirudin. Native hirudin, a 65-amino-acid polypeptide, is produced in the parapharyngeal glands of medicinal leeches. Hirudins today are produced by recombinant biotechnology using yeast. These recombinant hirudins lack a sulfate group at Tyr-63 and are therefore called desulfatohirudins. They have a 10-fold lower binding affinity to thrombin compared to native hirudin, but remain a highly specific inhibitor of thrombin and have an inhibition constant for thrombin in the picomolar range. Renal clearance and degradation account for the most part
Naturally occurring retirement community South Houses, a ten-building 2,800-unit moderate-income housing cooperative located in New York City, with support from the UJA/Federation of New York. Since then, the NORC program model has been broadly replicated at the local, state, and national levels and can be found in more than 25 states across the country. Naturally occurring retirement community A naturally occurring retirement community (NORC; ) is a term used to describe a community that has a large proportion of residents over 60 but was not specifically planned or designed to meet the needs of seniors living independently in their homes. NORCs may develop in