Discovery and development of direct Xa inhibitors Xa was identified as a promising target for the development of new anticoagulants in the early 1980s. In 1987 the first factor Xa inhibitor, the naturally occurring compound antistasin, was isolated from the salivary glands of the Mexican leech "Haementeria officinalis". Antistasin is a polypeptide and a potent Xa inhibitor. In 1990 another naturally occurring Xa inhibitor was isolated, tick anticoagulant peptide (TAP) from extracts of the tick "Ornithodoros moubata". TAP and antistasin were used to estimate factor Xa as a drug target. Blood coagulation is a complex process by which the blood forms clots. It is an essential part
Naturally occurring retirement community South Houses, a ten-building 2,800-unit moderate-income housing cooperative located in New York City, with support from the UJA/Federation of New York. Since then, the NORC program model has been broadly replicated at the local, state, and national levels and can be found in more than 25 states across the country. Naturally occurring retirement community A naturally occurring retirement community (NORC; ) is a term used to describe a community that has a large proportion of residents over 60 but was not specifically planned or designed to meet the needs of seniors living independently in their homes. NORCs may develop in