Hellenistic period Balkans, Philip allied himself with Carthage after Hannibal had dealt the Romans a massive defeat at the Battle of Cannae (216 BC) during the Second Punic War. Forcing the Romans to fight on another front when they were at a nadir of manpower gained Philip the lasting enmity of the Romans—the only real result from the somewhat insubstantial First Macedonian War (215–202 BC). Once the Second Punic War had been resolved, and the Romans had begun to regather their strength, they looked to re-assert their influence in the Balkans, and to curb the expansion of Philip. A pretext for war
Romans in Persia of the dynasties in control of their empires in different historical periods: first were the Medians (Media Atropatene), then Parthians and finally Sassanians. In 64 BC Pompey conquered the remaining Seleucid territories in Syria, extinguishing their state and advancing the Roman eastern frontier to the Euphrates, where Romans met for the first time the territory of the Parthians. Mark Antony, in his quest to avenge the battle of Carrhae defeat, conquered in 33 BC some areas of Atropatene (northern Iran) and Armenia but soon lost it: that was the first time that Romans occupied a Persian territory, even if temporarily.