Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Facial symmetry associated with the symmetry of the face. Hormones such as testosterone and estrogen are believed to be associated with developmental processes and growth of facial features during puberty and as a result are hypothesized to be the cause for individual differences in the implications associated with facial symmetry. Facial bilateral symmetry is measured via fluctuating asymmetry of the face comparing random differences in facial features of the two sides of the face that develop and accumulate throughout one's lifetime as a result of stressors. Facial symmetry has been shown to have an effect of ratings of attractiveness in human faces.