Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Rise to Remain to Remain contributed a cover of the song "Breed", on a cover album featuring artists such as The Dillinger Escape Plan (who covered "Territorial Pissings"), Evile (who covered "Lounge Act"), and The Blackout (covering "Stay Away"). After concluding the tour supporting Trivium and In Flames, Rise to Remain closed their touring commitments for 2011. Starting on 15 January 2012, Rise to Remain were meant to support Machine Head on their North American tour along with Suicide Silence and Darkest Hour in support. However, on 6 January 2012, bassist Joe Copcutt and drummer Pat Lundy announced their departure from the band,