Glossitis of the tongue in iron deficiency anemia has been described as diffuse or patchy atrophy with tenderness or burning. One cause of iron deficiency anemia is sideropenic dysphagia (Plummer–Vinson or Paterson–Brown–Kelly syndrome) which is also characterized by esophageal webbing and dysphagia. Pernicious anemia is usually caused by autoimmune destruction of gastric parietal cells. Parietal cells secrete intrinsic factor which is required for the absorption of vitamin B12. Vitamin B12 deficiency results in megaloblastic anemia and may present as glossitis. The appearance of the tongue in vitamin B12 deficiency is described as "beefy" or "fiery red and sore". There may be
National Farm Medicine Center National Farm Medicine Center The National Farm Medicine Center (NFMC), established in 1981, is a non-profit program in Marshfield, Wisconsin dedicated to agricultural health and safety research, and service. The center is a component of the Marshfield Clinic Research Foundation, which is part of Marshfield Clinic. In the 1960s research was conducted by the Marshfield Clinic Research Foundation on respiratory diseases common in dairy farmers. Dean Emanuel identified maple bark disease among paper mill workers. In 1964, a culture technique developed by Emanuel and Fritz Wenzel to identify the causative agent for "farmer's lung", a chronic, progressive, inflammation in the