Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Rise to Remain Rise to Remain Rise to Remain was a London-based heavy metal band, formed in 2006 and disbanded in 2015. The band made appearances at Download Festival, Sonisphere Festival and extensively toured the UK and Europe. The band released three EPs, the majority of which were "viral" releases, via their MySpace. On 16 March 2011 they signed their first major recording contract with EMI records, which was accompanied by the launch of their website and a free single download entitled "The Serpent". Their debut album, "City of Vultures", was released on 5 September 2011, nearly a year after they had started