Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood young people fully enter adulthood. If the years 18–25 are classified as "young adulthood", Arnett believes it is then difficult to find an appropriate term for the thirties. Emerging adults are still in the process of obtaining an education, are unmarried, and are childless. By age thirty, most of these individuals do see themselves as adults, based on the belief that they have more fully formed "individualistic qualities of character" such as self-responsibility, financial independence, and independence in decision-making. Arnett suggests that many of the individualistic characteristics associated with adult status correlate to, but are not dependent upon, the role