Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood OECD nations, and as a stage of development has only emerged over the past half century. It is specific to "certain cultural-demographic conditions, specifically widespread education and training beyond secondary school and entry into marriage and parenthood in the late twenties (or early thirties) or beyond". Furthermore, emerging adulthood occurs only within societies that allow for occupational shifts, with emerging adults often experiencing frequent job changes before settling on particular job by the age of 30. Arnett also argues that emerging adulthood happens in cultures that allow for a period of time between adolescence and marriage, the marker of adulthood.