Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Facial tissue and its use. Facial tissue and paper handkerchiefs are made from the lowest basis weights tissue paper (14 18 g/m). The surface is often made smoother by light calendering. These paper types consist usually of 2–3 plies. Because of high quality requirements the base tissue is normally made entirely from pure chemical pulp, but might contain added selected recycled fiber. The tissue paper might be treated with softeners, lotions or added perfume to get the right properties or "feeling". The finished facial tissues or handkerchiefs are folded and put in pocket-size packages or a box dispenser. Facial tissue has been