Seymour family V's visit to England in 1522. The eldest of his ten children was Edward Seymour, 1st Duke of Somerset, the famous Protector in the reign of Edward VI; his third son was Thomas Seymour, Baron Seymour of Sudeley; and his eldest daughter Jane was third wife of King Henry VIII, and mother of Edward VI. The Protector was married twice; and, probably owing to the adultery of his first wife whom he repudiated about 1535, his titles and estates were entailed first on the issue of his second marriage with Anne, daughter of Sir Edward Stanhope. The Protector's eldest surviving
Charles Seymour, 6th Duke of Somerset 1748 and was buried in the Seymour Chapel of Salisbury Cathedral in Wiltshire, where survives the elaborate monument to his ancestor Edward Seymour, 1st Earl of Hertford (1539–1621), son of the 1st Duke of Somerset. Shortly before his death he foresaw that his own line of the Seymour family was about to die out in the male line and that as was said of the 9th Duke of Norfolk (d.1777) "the honours of his family were about to pass away from his own line to settle on that of a distant relative". His son and heir apparent Algernon Seymour, Earl