Scooby-Doo on Zombie Island sequences of interplay between Shaggy and Scooby for him. After Don Messick's death, Scott Innes replaced Messick as the voice of Scooby-Doo. Casey Kasem did not reprise his role as Shaggy Rogers as he wished to only voice Shaggy if the character became a vegetarian, like himself. Instead, Billy West provided the voice for Shaggy. Mary Kay Bergman was cast as Daphne when the character was taken in a new direction. B.J. Ward, who played Velma in the "Johnny Bravo" crossover episode, reprised her role in this film. Frank Welker is the only actor from the original series to reprise
Scooby-Doo and the Cyber Chase is also the fourth and final Scooby-Doo direct-to-video film to be animated overseas by Japanese animation studio Mook Animation. This movie, along with "Aloha, Scooby-Doo!", was part of the first Scooby-Doo re-release on Blu-ray on April 5, 2011. This was also the first movie to feature Grey DeLisle as the voice of Daphne Blake after the death of Mary Kay Bergman in 1999. This was also the last film Scott Innes voiced Scooby-Doo and Shaggy, as well as the last film where B. J. Ward voiced Velma. A video game based on the film was released by THQ in 2001