Felidae carnivores, meaning they are dependent on nutrients in animal flesh for survival, and because of the large proportion of meat in their diet they are sometimes referred to as hypercarnivores. Of the 13 terrestrial families in the order Carnivora, they are the strictest carnivores. The Felidae comprises two subfamilies, the Pantherinae and the Felinae. The former includes the "Panthera" species tiger, lion, jaguar, leopard, snow leopard, and "Neofelis" species clouded leopard and Sunda clouded leopard. All the non-pantherine cats are part of the Felinae, which includes several genera and the majority of cat species. The first cats emerged during the
Fund for the Replacement of Animals in Medical Experiments Michael Balls. FRAME receives no direct funding from local or central government and relies entirely on donations, legacies and corporate support. A list of its current corporate supporters is available in its annual report each year. Fund for the Replacement of Animals in Medical Experiments Fund for the Replacement of Animals in Medical Experiments (FRAME) is a charity based in Nottingham, UK. FRAME promotes consideration of the ethical and scientific issues involved in the use of laboratory animals for medical research, and the adoption of the Three Rs strategy of alternatives to animal testing. The Three Rs (Replacement, Reduction, Refinement)