Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood and take on responsibility. "Failure to Launch" and "Step Brothers" are extreme examples of this concept. While most takes on emerging adulthood (and the problems that it can cause) are shown in a light-humored attempt to poke fun at the idea, a few films have taken a more serious approach to the plight. "Adventureland", "Take Me Home Tonight", "Cyrus" and "Jeff, Who Lives at Home" are comedy-dramas that exhibit the plight of today's emerging adult. Television also is capitalizing on the concept of emerging adulthood with sitcoms such as "$h*! My Dad Says" and "Big Lake". However, it is not