Facial composite In the U.S. the FBI maintains that hand-drawing is its preferred method for constructing a facial composite. Many other police agencies, however, use software, since suitable artistic talent is often not available. Until quite recently, the facial composite systems used by international police forces were exclusively based on a construction methodology in which individual facial features (eyes, nose, mouth, eyebrows, etc.) are selected one at a time from a large database and then electronically 'overlaid' to make the composite image. Such systems are often referred to as feature-based since they essentially rely on the selection of individual features in isolation.
Immunodeficiency–centromeric instability–facial anomalies syndrome Immunodeficiency–centromeric instability–facial anomalies syndrome ICF syndrome (or Immunodeficiency, Centromere instability and Facial anomalies syndrome) is a very rare autosomal recessive immune disorder. It is characterized by variable reductions in serum immunoglobulin levels which cause most ICF patients to succumb to infectious diseases before adulthood. ICF syndrome patients exhibit facial anomalies which include hypertelorism, low-set ears, epicanthal folds and macroglossia. ICF syndrome can be caused by a mutation in the DNA-methyltransferase-3b ("Dnmt3b") gene, located on chromosome 20q11.2. The disease is inherited in an autosomal recessive manner. For ICF patients the most diffused therapy consists of repeated intravenous infusions of immunoglobulins for