Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood people made the transition from adolescence to young adulthood around or by the age of 22, when they settled into long-lasting, obligation-filled familial and occupational roles. Therefore, in societies where this trend still prevails, emerging adulthood does not exist as a widespread stage of development. Among OECD countries, there is a general "one size fits all" model in regards to emerging adulthood, having all undergone the same demographic changes that resulted in this new stage of development between adolescence and young adulthood. However, the shape emerging adulthood takes can even vary between different OECD countries, and researchers have only recently