Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood to those in poor or rural parts of developing nations, who have no emerging adulthood and sometimes no adolescence due to comparatively early entry into marriage and adult-like work, young people in wealthier urban classes have begun to enter stages of development that resemble emerging adulthood, and the amount to do so is rising. Such individuals may develop a bicultural or hybrid identity, with part of themselves identifying with local culture and another part participating in the professional culture of the global economy. One finds examples of such a situation among the middle class young people in India, who lead