Patella present in the living monotremes, the platypus and the echidna. In more primitive tetrapods, including living amphibians and most reptiles (except some Lepidosaurs), the muscle tendons from the upper leg are attached directly to the tibia, and a patella is not present. In 2017 it was discovered that frogs have kneecaps, contrary to what was thought. This raises the possibility that the kneecap arose 400 million years ago when tetrapods first appeared, but that it disappeared in some animals. The word "patella" originated in the late 17th century from the diminutive form of Latin ' or ' or "paten", meaning
Traditional Chinese medicines derived from the human body were successfully making quasi-empirical preparations of active substances with androgens and estrogens, a technique that modern biochemists did not develop until the early 20th century. The physician William C. Cooper and the sinologist Nathan Sivin (1973) chose what the Chinese call "rényào" 人藥 "human drugs" as a pilot experiment sample for pharmacologically analyzing the efficacy of drugs used in TCM. In contrast to many traditional Chinese plant, animal, and mineral pharmaceuticals with uncertain active constituents, the chemical composition of the human body and parts is well known, and "their therapeutic effectiveness, or lack of it, can be objectively, if approximately,