Scooby-Doo on Zombie Island sequences of interplay between Shaggy and Scooby for him. After Don Messick's death, Scott Innes replaced Messick as the voice of Scooby-Doo. Casey Kasem did not reprise his role as Shaggy Rogers as he wished to only voice Shaggy if the character became a vegetarian, like himself. Instead, Billy West provided the voice for Shaggy. Mary Kay Bergman was cast as Daphne when the character was taken in a new direction. B.J. Ward, who played Velma in the "Johnny Bravo" crossover episode, reprised her role in this film. Frank Welker is the only actor from the original series to reprise
Shaggy & Scooby-Doo Get a Clue! form, to a high-tech transforming vehicle. However, it usually transforms into machines inappropriate for the tasks at hand (however, in episode 11, it does transform into vehicles appropriate to finish the Polar Bear 3000). In their spare time, Shaggy and Scooby are fans of the show "Chefs of Steel", and the famous mystery solver Chad Chaddington. This is the first Scooby-Doo animated series since 1991 to make extensive use of the Castle Thunder sound effect, which Hanna-Barbera began to stop using around 1994, and was very rarely used on "What's New, Scooby-Doo?" and on none of the post-2003 direct-to-video Scooby-Doo