Scooby-Doo on Zombie Island are real!" The movie was dedicated to the memory of Don Messick, the original voice of Scooby-Doo, who died nearly a year before the film's release. The movie is also one of Ed Gilbert's final roles. The members of Mystery, Inc. go their separate ways after becoming bored of mystery solving. Daphne Blake, along with Fred Jones, starts running a successful television series. Velma Dinkley becomes the proprietor of a mystery bookstore, and Scooby-Doo and his owner Shaggy Rogers bounce from job to job. For Daphne's birthday, Fred decides to get the gang back together for a road trip while
Scooby-Doo and the Cyber Chase is also the fourth and final Scooby-Doo direct-to-video film to be animated overseas by Japanese animation studio Mook Animation. This movie, along with "Aloha, Scooby-Doo!", was part of the first Scooby-Doo re-release on Blu-ray on April 5, 2011. This was also the first movie to feature Grey DeLisle as the voice of Daphne Blake after the death of Mary Kay Bergman in 1999. This was also the last film Scott Innes voiced Scooby-Doo and Shaggy, as well as the last film where B. J. Ward voiced Velma. A video game based on the film was released by THQ in 2001