Seymour family V's visit to England in 1522. The eldest of his ten children was Edward Seymour, 1st Duke of Somerset, the famous Protector in the reign of Edward VI; his third son was Thomas Seymour, Baron Seymour of Sudeley; and his eldest daughter Jane was third wife of King Henry VIII, and mother of Edward VI. The Protector was married twice; and, probably owing to the adultery of his first wife whom he repudiated about 1535, his titles and estates were entailed first on the issue of his second marriage with Anne, daughter of Sir Edward Stanhope. The Protector's eldest surviving
John Seymour, 4th Duke of Somerset by his cousin, Francis Seymour. John Seymour, 4th Duke of Somerset John Seymour, 4th Duke of Somerset (before 1646 – 29 April 1675) was an English peer and MP. He was the only surviving son of William Seymour, 2nd Duke of Somerset and Lady Frances Devereux and entered Grays Inn in 1666. He succeeded his nephew as the 4th Duke of Somerset in 1671. In 1656 he married Sarah, daughter and co-heiress of Sir Edward Alston and widow of George Grimston. He was elected Member of Parliament for Marlborough in 1661. He died in 1675, childless, and was buried in