Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Reroute to Remain present singles, which were "Trigger" and "Cloud Connected". Despite initially receiving a mixed response from fans, the album received mostly favorable reviews. In 2005, "Reroute to Remain" was ranked number 326 in "Rock Hard" magazine's book of "The 500 Greatest Rock & Metal Albums of All Time". The album peaked at No. 13 on the "Billboard" Independent Albums chart. Reroute to Remain Reroute to Remain (subtitled: Fourteen Songs of Conscious Insanity, and on reissue: Fourteen Songs of Conscious Madness) is the sixth studio album by the Swedish metal band In Flames. The album saw a major change in musical style