Caduceus as a symbol of medicine significance of both symbols. This has occasioned impassioned remarks by those frustrated with the continuing confusion. It has been observed that the caduceus is particularly inappropriate for use as a medical symbol due to its long associations with the Greek god Hermes, who was patron of commerce and traders as well as thieves, liars, and gamblers. On the other hand, it has also been remarked – not without considerable irony – that commercial aims in medicine, especially in the United States of America, make the caduceus "an appropriate symbol", at least for some physicians. Others are unapologetic about the association
Caduceus as a symbol of medicine of Hermes Trismegistus ("Thrice-Great Hermes") with early chemistry and medicine as aspects of alchemy as an esoteric practice. He notes however, that "although these various factors may link Hermes/Mercury, along with his caduceus, with alchemical medicine, they may just as well link all the other non-medical aspects of alchemy with Hermes/Mercury and the caduceus." Beginning with the 16th century there is limited evidence of the use of the caduceus in what is arguably a medical context. However, this evidence is also ambiguous. In some cases it is clear that the caduceus symbolized wisdom, without any specific medical connotations. The caduceus