Caduceus as a symbol of medicine significance of both symbols. This has occasioned impassioned remarks by those frustrated with the continuing confusion. It has been observed that the caduceus is particularly inappropriate for use as a medical symbol due to its long associations with the Greek god Hermes, who was patron of commerce and traders as well as thieves, liars, and gamblers. On the other hand, it has also been remarked – not without considerable irony – that commercial aims in medicine, especially in the United States of America, make the caduceus "an appropriate symbol", at least for some physicians. Others are unapologetic about the association
Caduceus as a symbol of medicine appears in a general medical context in the printer's device used by the Swiss medical printer Johann Frobenius (1460–1527), who depicted the staff entwined with serpents and surmounted by a dove, with a biblical epigraph in Greek, "Be ye therefore wise as serpents and harmless as doves" (Matthew 10:16, here in the KJV translation), in keeping with the connotations of the caduceus as a symbol of messengers and publishers based on the association of Hermes or Mercury with eloquence and negotiation. Friedlander observed that Frobenius could hardly be considered a medical printer, as had previously been asserted, noting that in