Glossitis of the tongue in iron deficiency anemia has been described as diffuse or patchy atrophy with tenderness or burning. One cause of iron deficiency anemia is sideropenic dysphagia (Plummer–Vinson or Paterson–Brown–Kelly syndrome) which is also characterized by esophageal webbing and dysphagia. Pernicious anemia is usually caused by autoimmune destruction of gastric parietal cells. Parietal cells secrete intrinsic factor which is required for the absorption of vitamin B12. Vitamin B12 deficiency results in megaloblastic anemia and may present as glossitis. The appearance of the tongue in vitamin B12 deficiency is described as "beefy" or "fiery red and sore". There may be
Medieval medicine of Western Europe believed that it took longer for the soul to leave as it was an integral part of the body. Though medical practice had become a professional and institutionalized field, the argument of the soul in the case of dissection shows that the foundation of religion was still an important part of medical thought in the late Middle Ages. Medicine was not a formal area of study in early medieval medicine, but it grew in response to the proliferation of translated Greek and Arabic medical texts in the 11th century. Western Europe also experienced economic, population and urban growth in the