Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood issue. As individuals move through emerging adulthood, they are more likely to engage in monogamous sexual relationships and practice safe sex. Across most OECD countries, marriage rates are falling, the age at first marriage is rising, and cohabitation among unmarried couples is increasing. The Western European marriage pattern has traditionally been characterised by marriage in the mid twenties, especially for women, with a generally small age difference between the spouses, a significant proportion of women who remain unmarried, and the establishment of a neolocal household after the couple has married. Housing affordability has been linked to home ownership rates, and