Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood having had premarital sexual relations by the age of 20, whereas less than 20% in Japan and South Korea reported the same. While emerging adulthood exemplars are found mainly within the middle and upper classes of OECD countries, the stage of development still seems to occur across classes, with the main difference between different ones being length—on average, young people in lower social classes tend to enter adulthood two years before those in upper classes. While emerging adulthood occurs on a wide scale only in OECD countries, developing countries may also exhibit similar phenomena in certain population subgroups. In contrast