Glossitis of the tongue in iron deficiency anemia has been described as diffuse or patchy atrophy with tenderness or burning. One cause of iron deficiency anemia is sideropenic dysphagia (Plummer–Vinson or Paterson–Brown–Kelly syndrome) which is also characterized by esophageal webbing and dysphagia. Pernicious anemia is usually caused by autoimmune destruction of gastric parietal cells. Parietal cells secrete intrinsic factor which is required for the absorption of vitamin B12. Vitamin B12 deficiency results in megaloblastic anemia and may present as glossitis. The appearance of the tongue in vitamin B12 deficiency is described as "beefy" or "fiery red and sore". There may be
Medieval medicine of Western Europe was one of the "leading Italian universities in teaching medicine, identification and treating of diseases and ailments, specializing in autopsies and workings of the body." The most prestigious and famous part of the university is the oldest surviving anatomical theater, in which students studied anatomy by observing their teachers perform public dissections. Surgery was formally taught in Italy even though it was initially looked down upon as a lower form of medicine. The most important figure of the formal learning of surgery was Guy de Chauliac. He insisted that a proper surgeon should have a specific knowledge of the human