Pronation of the foot with many overuse injuries in running including medial tibial stress syndrome, or shin splints, and knee pain Hintermann states, “Individuals with injuries typically have pronation movement that is about two to four degrees greater than that of those with no injuries.” He adds however, that between 40% and 50% of runners who overpronate do not have overuse injuries. This suggests that although pronation may have an effect on certain injuries, it is not the only factor influencing their development. The design principles of foot orthoses are founded on knowledge of the functional anatomy of the foot. Pronation of the foot
Stress (biology) to a stressor - a stimulus, real or imagined, that causes stress. Acute stressors affect an organism in the short term; chronic stressors over the longer term. The general adaptation syndrome (GAS), developed by Hans Selye, is a profile of how organisms respond to stress; GAS is characterized by three phases: a nonspecific mobilization phase, which promotes sympathetic nervous system activity; a resistance phase, during which the organism makes efforts to cope with the threat; and an exhaustion phase, which occurs if the organism fails to overcome the threat and depletes its physiological resources. Alarm is the first stage, which