Seymour family V's visit to England in 1522. The eldest of his ten children was Edward Seymour, 1st Duke of Somerset, the famous Protector in the reign of Edward VI; his third son was Thomas Seymour, Baron Seymour of Sudeley; and his eldest daughter Jane was third wife of King Henry VIII, and mother of Edward VI. The Protector was married twice; and, probably owing to the adultery of his first wife whom he repudiated about 1535, his titles and estates were entailed first on the issue of his second marriage with Anne, daughter of Sir Edward Stanhope. The Protector's eldest surviving
Edward Seymour, 8th Duke of Somerset and wife Elizabeth Somner, daughter of John Somner, of Seend. They had at least five children. In December 1740, his father died and Seymour inherited his manors in Wiltshire and Devon. On 11 September 1744, with the unexpected death of George Seymour, Viscount Beauchamp (1725–1744), the only son of Algernon Seymour, 7th Duke of Somerset, the likelihood emerged of Seymour succeeding his distant cousin as Duke of Somerset and Baron Seymour, as the 7th Duke was then aged sixty, and his wife was past child-bearing age. On 23 November 1750 the Duke died, and Seymour duly succeeded to his titles.