Felidae Oligocene, about 25 million years ago, with the appearance of "Proailurus" and "Pseudaelurus". The latter species complex was ancestral to two main lines of felids, the cats in the extant subfamilies and a third major group of extinct cats, which are assigned to the subfamily Machairodontinae. The machairodonts included the saber-toothed cats such as the "Smilodon". The "false sabre toothed cats", the Barbourofelidae and Nimravidae, are not true cats, but are closely related and together with Felidae and other cat-like carnivores (hyaenas, viverrids and mongooses) make up the feliform carnivores. Results of mitochondrial analysis indicates that all the Felidae descended
Fund for the Replacement of Animals in Medical Experiments a pamphlet style publication, was relaunched as a peer-reviewed international scientific journal. 1983 - FRAME joined with the British Veterinary Association (BVA) and the Committee for the Reform of Animal Experimentation (CRAE) to advise the government on the Animals (Scientific Procedures) Act. 1984 - FRAME receives first ever government grant to research replacement methods 1986 - FRAME expanded into new premises on the 1st floor of Eastgate House in the historic Lace Market area of Nottingham. In the same year, FRAME received the first Marchig Animal Welfare Award from the World Society for the Protection of Animals (Now known as