Glossitis is usually very painful, and there may be erosions present in the depths of the fissures. Similar fissured lesions which are not associated with HSV, as may occur in fissured tongue, do not tend to be painful. The name comes from the geometric pattern of the fissures which are longitudinal, crossed or branched. It is described as occurring in immunocompromized persons, e.g. who have leukemia. However, the association between herpes simplex and geometric glossitis is disputed by some due to a lack of gold standard techniques for diagnosis of intraoral herpetic lesions, and the high prevalence of asymptomatic viral shedding
National Farm Medicine Center National Farm Medicine Center The National Farm Medicine Center (NFMC), established in 1981, is a non-profit program in Marshfield, Wisconsin dedicated to agricultural health and safety research, and service. The center is a component of the Marshfield Clinic Research Foundation, which is part of Marshfield Clinic. In the 1960s research was conducted by the Marshfield Clinic Research Foundation on respiratory diseases common in dairy farmers. Dean Emanuel identified maple bark disease among paper mill workers. In 1964, a culture technique developed by Emanuel and Fritz Wenzel to identify the causative agent for "farmer's lung", a chronic, progressive, inflammation in the