Pronation of the foot with many overuse injuries in running including medial tibial stress syndrome, or shin splints, and knee pain Hintermann states, “Individuals with injuries typically have pronation movement that is about two to four degrees greater than that of those with no injuries.” He adds however, that between 40% and 50% of runners who overpronate do not have overuse injuries. This suggests that although pronation may have an effect on certain injuries, it is not the only factor influencing their development. The design principles of foot orthoses are founded on knowledge of the functional anatomy of the foot. Pronation of the foot
Oxidative stress HO (hydrogen peroxide). Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. In humans, oxidative stress is thought to be involved in the development of ADHD, cancer, Parkinson's disease, Lafora disease, Alzheimer's syndrome, atherosclerosis, heart failure, myocardial infarction, fragile X syndrome, sickle-cell disease, lichen planus, vitiligo, autism, infection, chronic fatigue syndrome, and depression and seems to be characteristic of individuals with Asperger syndrome. However, reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill