Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Facial hair some cases, women have noticeable facial hair growth, most commonly after menopause. Excessive hairiness (especially facially) is known as hirsutism and is usually an indication of atypical hormonal variation. In contemporary Western culture, many women depilate facial hair that appears, as considerable social stigma is associated with facial hair on women, and freak shows and circuses have historically displayed bearded women. Many women globally choose to totally remove their facial hair by professional laser treatment. Great apes such as orangutan males seem to have facial hair as well. In chimpanzees and bonobos, facial and body hair become sparser in adulthood