Jack and Jill (nursery rhyme) and brown paper were a home cure used as a method to draw out bruises on the body. Jack is the most common name used in English-language nursery rhymes and represented an archetypal Everyman hero by the 18th century, while Jill or Gill had come to mean a young girl or a sweetheart by the end of the Middle Ages. However, the woodcut that accompanied the first recorded version of the rhyme showed two boys (not a boy and a girl) and used the spelling Gill not Jill. The true origin of the rhyme is unknown, but there are several
(S)-canadine synthase (S)-canadine synthase In enzymology, a (S)-canadine synthase () is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are (S)-tetrahydrocolumbamine, NADPH, H, and O, whereas its 3 products are (S)-canadine, NADP, and HO. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming). Other names in common use include (S)-tetrahydroberberine synthase,