Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood to Arnett, the term "young adulthood" suggests that adulthood has already been reached, but most people in the emerging adulthood stage no longer consider themselves adolescents, but do not see themselves entirely as adults either. In the past, milestones such as finishing secondary school, finding a job, and getting married clearly marked the entrance to adulthood, but in modern, post-industrialized nations, as positions requiring a college degree have become more common and the average age of marriage has become older the length of time between leaving adolescence and reaching these milestones has been extended, delaying the age at which many