Honey Bunny the Nips" (1944), a shapely robotic female rabbit used as a bait for Bugs by Gossamer's creator in the cartoon "Hair-Raising Hare" (1946), Daisy Lou (who bears a strong resemblance to Honey Bunny's eventual character design from the 1970s-1990s) in the above-mentioned cartoon "Hare Splitter" (1948), Witch Hazel (who is transformed into an attractive female rabbit) in the cartoon "Bewitched Bunny" (1954), and Millicent (an overweight rabbit) in the cartoon "Rabbit Romeo" (1957). Mama Bear, in "Bugs Bunny and the Three Bears" (1944); Penelope Pussycat, in "Carrotblanca" (1995); and Elmer Fudd, in "Bugs' Bonnets" (1956) and "Rabbit of Seville" (1950),
Bugs Bunny Avery for his first Bugs Bunny film, "A Wild Hare" (1940). Avery explained later that it was a common expression in his native Texas and that he did not think much of the phrase. When the cartoon was first screened in theaters, the "What's up, Doc?" scene generated a tremendously positive audience reaction. As a result, the scene became a recurring element in subsequent cartoons. The phrase was sometimes modified for a situation. For example, Bugs says "What's up, dogs?" to the antagonists in "A Hare Grows in Manhattan", "What's up, Duke?" to the knight in "Knight-mare Hare," and "What's