Glossitis is usually very painful, and there may be erosions present in the depths of the fissures. Similar fissured lesions which are not associated with HSV, as may occur in fissured tongue, do not tend to be painful. The name comes from the geometric pattern of the fissures which are longitudinal, crossed or branched. It is described as occurring in immunocompromized persons, e.g. who have leukemia. However, the association between herpes simplex and geometric glossitis is disputed by some due to a lack of gold standard techniques for diagnosis of intraoral herpetic lesions, and the high prevalence of asymptomatic viral shedding
University of Pennsylvania School of Dental Medicine such areas as oral microbiology and virology, inflammation and immunity, tooth development, and the use of analgesics and sedatives, to the cellular biology of connective tissues and bone, the applications for state-of-the-art dental materials, and the causes and effects of periodontal disease. Interdisciplinary research is a hallmark of the University of Pennsylvania, and Penn Dental Medicine investigators collaborate extensively with faculty throughout the Penn campus. University of Pennsylvania School of Dental Medicine The University of Pennsylvania School of Dental Medicine (often referred to as Penn Dental Medicine or simply Penn Dental) is the dental school of the University of Pennsylvania