Seymour family V's visit to England in 1522. The eldest of his ten children was Edward Seymour, 1st Duke of Somerset, the famous Protector in the reign of Edward VI; his third son was Thomas Seymour, Baron Seymour of Sudeley; and his eldest daughter Jane was third wife of King Henry VIII, and mother of Edward VI. The Protector was married twice; and, probably owing to the adultery of his first wife whom he repudiated about 1535, his titles and estates were entailed first on the issue of his second marriage with Anne, daughter of Sir Edward Stanhope. The Protector's eldest surviving
Duke of Somerset him Marquess of Hertford in 1640 and on 13 September 1660, shortly before his death on 24 October, the title of Duke of Somerset was granted to him as its legitimate heir; following its non-existence for 108 years. He outlived his three eldest sons and as the dukedom descends to heirs male of the holder of the 1547 grant it passed to William Seymour (1654–1671) who was the son of the third son mentioned (lived 1626–1654). The 3rd duke died unmarried and the title passed to John Seymour (bef. 1646–1675) the last surviving son of the 2nd Duke, his uncle.