Facial expression responsible for controlling the expression differ in each case. Voluntary facial expressions are often socially conditioned and follow a cortical route in the brain. Conversely, involuntary facial expressions are believed to be innate and follow a subcortical route in the brain. Facial recognition is often an emotional experience for the brain and the amygdala is highly involved in the recognition process. The eyes are often viewed as important features of facial expressions. Aspects such as blinking rate can possibly be used to indicate whether a person is nervous or whether he or she is lying. Also, eye contact is considered
Immunodeficiency–centromeric instability–facial anomalies syndrome Immunodeficiency–centromeric instability–facial anomalies syndrome ICF syndrome (or Immunodeficiency, Centromere instability and Facial anomalies syndrome) is a very rare autosomal recessive immune disorder. It is characterized by variable reductions in serum immunoglobulin levels which cause most ICF patients to succumb to infectious diseases before adulthood. ICF syndrome patients exhibit facial anomalies which include hypertelorism, low-set ears, epicanthal folds and macroglossia. ICF syndrome can be caused by a mutation in the DNA-methyltransferase-3b ("Dnmt3b") gene, located on chromosome 20q11.2. The disease is inherited in an autosomal recessive manner. For ICF patients the most diffused therapy consists of repeated intravenous infusions of immunoglobulins for