Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Emerging adulthood and early adulthood of various disorders prevalent in emerging adulthood, but the chance of developing a disorder drastically decreases at age 28. Seventy-five percent of any lifetime DSM-IV anxiety, mood, impulse-control and substance abuse disorder begins before age 24. Most onsets at this age will not be, or become, comorbid. The median onset interquartile range of substance use disorders is 18–27, while the median onset age is 20. The median onset age of mood disorders is 25. Even disorders that begin earlier, like schizophrenia spectrum diagnoses, can reveal themselves within the age range of emerging adulthood. Often, patients will not seek help until