Anne Seymour, Duchess of Somerset Anne Seymour, Duchess of Somerset Anne Seymour, Duchess of Somerset (née Stanhope) (c.1510 – 16 April 1587) was the second wife of Edward Seymour, 1st Duke of Somerset (c.1500–1552), who held the office of Lord Protector during the first part of the reign of his nephew King Edward VI, through whom Anne was briefly the most powerful woman in England. During her husband's time as Lord Protector she claimed precedence over the dowager queen Catherine. Anne Stanhope was likely born in 1510, the only child of Sir Edward Stanhope (1462 – 6 June 1511) by his wife Elizabeth Bourchier (b.
Charles Seymour, 6th Duke of Somerset of Hertford (1684–1749) had produced a son of his own, Lord Beauchamp (d.1744), who had predeceased him without progeny, and thus he had only a daughter and sole heiress Lady Elizabeth Seymour, who in 1740 had married Sir Hugh Smithson, 4th Baronet. Before the death of the 6th duke in 1748, it had thus become apparent that the dukedom of Somerset would devolve by law onto an extremely distant cousin and heir male, the 6th duke's 6th cousin Sir Edward Seymour, 6th Baronet (1695–1757) of Berry Pomeroy in Devon and of Maiden Bradley in Wiltshire, who in fact represented the