Forensic facial reconstruction accurate reconstruction possible is largely limited. A second problem is the lack of a methodological standardization in approximating facial features. A single, official method for reconstructing the face has yet to be recognized. This also presents major setback in facial approximation because facial features like the eyes and nose and individuating characteristics like hairstyle - the features most likely to be recalled by witnesses - lack a standard way of being reconstructed. Recent research on computer-assisted methods, which take advantage of digital image processing, pattern recognition, promises to overcome current limitations in facial reconstruction and linkage. Reconstructions only reveal the
Immunodeficiency–centromeric instability–facial anomalies syndrome Immunodeficiency–centromeric instability–facial anomalies syndrome ICF syndrome (or Immunodeficiency, Centromere instability and Facial anomalies syndrome) is a very rare autosomal recessive immune disorder. It is characterized by variable reductions in serum immunoglobulin levels which cause most ICF patients to succumb to infectious diseases before adulthood. ICF syndrome patients exhibit facial anomalies which include hypertelorism, low-set ears, epicanthal folds and macroglossia. ICF syndrome can be caused by a mutation in the DNA-methyltransferase-3b ("Dnmt3b") gene, located on chromosome 20q11.2. The disease is inherited in an autosomal recessive manner. For ICF patients the most diffused therapy consists of repeated intravenous infusions of immunoglobulins for