Median rhomboid glossitis longest dimension. Predisposing factors include smoking, denture wearing, use of corticosteroid sprays or inhalers and human immunodeficiency virus (HIV) infection. "Candida" species even in healthy people mainly colonizes the posterior dorsal tongue. Median rhombiod glossitis is thought to be a type of chronic atrophic (or erythematous) candidiasis. Microbiological culture of the lesion usually shows "Candida" mixed with bacteria. The diagnosis is usually made on the clinical appearance, and tissue biopsy is not usually needed. The histologic picture is one of superficial candidal hyphal infiltration and a polymorphonuclear leukocytic inflammatory infiltrate present in the epithelium. The rete ridges are elongated and
National Farm Medicine Center National Farm Medicine Center The National Farm Medicine Center (NFMC), established in 1981, is a non-profit program in Marshfield, Wisconsin dedicated to agricultural health and safety research, and service. The center is a component of the Marshfield Clinic Research Foundation, which is part of Marshfield Clinic. In the 1960s research was conducted by the Marshfield Clinic Research Foundation on respiratory diseases common in dairy farmers. Dean Emanuel identified maple bark disease among paper mill workers. In 1964, a culture technique developed by Emanuel and Fritz Wenzel to identify the causative agent for "farmer's lung", a chronic, progressive, inflammation in the