Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Separated at birth physical similarities to humorous effect. There were several "Separated at Birth?" books issued around the same time, with whimsical comparisons such as Mick Jagger vs. Don Knotts as the fictional film character "The Incredible Mr. Limpet". Separated at birth Separated at birth, usually phrased as a question, is a light-hearted media device for pointing out people who are unrelated but bear a notable facial resemblance, implying that they are twins who were separated soon after being born and presumably adopted by separate families. The title "Separated at Birth?" was a trademark of Spy Publishing Partners, the publishers of the now