Median rhomboid glossitis longest dimension. Predisposing factors include smoking, denture wearing, use of corticosteroid sprays or inhalers and human immunodeficiency virus (HIV) infection. "Candida" species even in healthy people mainly colonizes the posterior dorsal tongue. Median rhombiod glossitis is thought to be a type of chronic atrophic (or erythematous) candidiasis. Microbiological culture of the lesion usually shows "Candida" mixed with bacteria. The diagnosis is usually made on the clinical appearance, and tissue biopsy is not usually needed. The histologic picture is one of superficial candidal hyphal infiltration and a polymorphonuclear leukocytic inflammatory infiltrate present in the epithelium. The rete ridges are elongated and
University of Pennsylvania School of Dental Medicine such areas as oral microbiology and virology, inflammation and immunity, tooth development, and the use of analgesics and sedatives, to the cellular biology of connective tissues and bone, the applications for state-of-the-art dental materials, and the causes and effects of periodontal disease. Interdisciplinary research is a hallmark of the University of Pennsylvania, and Penn Dental Medicine investigators collaborate extensively with faculty throughout the Penn campus. University of Pennsylvania School of Dental Medicine The University of Pennsylvania School of Dental Medicine (often referred to as Penn Dental Medicine or simply Penn Dental) is the dental school of the University of Pennsylvania