Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome Branchio-oculo-facial syndrome (BOFS) is a disease that arises from a mutation in the TFAP2A gene. It is a rare autosomal dominant disorder that starts to affect a child's development before birth. Symptoms of this condition include skin abnormalities on the neck, deformities of the ears and eyes, and other distinctive facial features such a cleft lip along with slow growth, mental retardation and premature graying of hair. "Branchio" refers to the branchial arches, also known as the pharyngeal arches, of the affected individual. The branchial arches are structures in the developing embryo that give rise to certain tissues
Forensic facial reconstruction attached at twenty-one specific "landmark" areas that correspond to the reference data. These sites represent the average facial tissue thickness for persons of the same sex, race, and age as that of the remains. From this point on, all features are added using modeling clay. First, the facial muscles are layered onto the cast in the following order: temporalis, masseter, buccinator and occipito-frontals, and finally the soft tissues of the neck. Next, the nose and lips are reconstructed before any of the other muscles are formed. The lips are approximately as wide as the interpupillary distance. However, this distance varies