Spinone Italiano a hunting companion has created a loyal, intelligent dog that is easily trained, although some can be stubborn about performing a learned task if they see no point in it. Because they are sensitive, motivational training works best for this breed, as this gentle dog's feelings can easily be hurt when handled incorrectly. The Spinone can be a very active breed, but it is not a racy dog like most other hunting breeds. The Spinone typically moves at the relaxed trot that is characteristic of the breed. It has often been called the perfect dog to run or jog with,
Fibronectin type III domain Fibronectin type III domain The Fibronectin type III domain is an evolutionary conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 amino acids long and possesses a beta sandwich structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins. ABI3BP; ANKFN1; ASTN2; AXL; BOC;