The Net (substance) The Net (substance) The Net, in alchemy, is an alloy of copper and iron, whose crystal structure induces a network pattern on its surface. It was described in the 17th century by Sir Isaac Newton. Newton produced the substance by following what he regarded as a recipe, encoded in classical mythology, for part of the process of achieving the philosopher's stone. The relevant myth involved the god Vulcan finding his wife Venus (alchemical symbol for copper) in bed with the god Mars (alchemical symbol for iron) Newton's interpretation rested on typical alchemical associations, construing Vulcan as a stand-in for fire,
Ground substance as hyaluronic acid, heparan sulfate, dermatan sulfate, and chondroitin sulfate, proteoglycans which GAGs are bound to, and glycoproteins. Components of the ground substance are secreted by fibroblasts. Usually it is not visible on slides, because it is lost during staining in the preparation process. Link proteins such as vinculin, spectrin and actomyosin stabilize the proteoglycans and organize elastic fibers in the ECM. Changes in the density of ground substance can allow collagen fibers to form aberrant cross-links. Loose connective tissue is characterized by few fibers and cells, and a relatively large amount of ground substance. Dense connective tissue has a