Pandemic smallpox was responsible for 300–500 million deaths. As recently as the early 1950s, an estimated 50 million cases of smallpox occurred in the world each year. After successful vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in December 1979. To this day, smallpox is the only human infectious disease to have been completely eradicated, and one of two infectious viruses ever to be eradicated. Historically, measles was prevalent throughout the world, as it is highly contagious. According to the U.S. National Immunization Program, 90% of people were infected with measles by age 15.
Human extinction Robin Hanson argues that a refuge permanently housing as few as 100 people would significantly improve the chances of human survival during a range of global catastrophes. Some 21st century pop-science works, including "The World Without Us" by Alan Weisman, pose an artistic thought experiment: what would happen to the rest of the planet if humans suddenly disappeared? A threat of human extinction, such as through a technological singularity (also called an intelligence explosion), drives the plot of innumerable science fiction stories; an influential early example is the 1951 film adaption of "When Worlds Collide". Usually the extinction threat is