The Hangover Part II did not have the full support of my entire cast and crew." Liam Neeson replaced Gibson after being invited by Cooper, who worked with Neeson on "The A-Team", to take the part. Neeson, a fan of the first film stated, "I just got a call to do a one-day shoot on 'Hangover 2' as a tattooist in Thailand, and that's all I know about it". Gibson was reportedly furious over the decision. A source close to Gibson stated, "He doesn't understand why Mike Tyson, a drug user who turned his life around, was given a chance while Mel was kicked
The Hangover Part II audience was 51 percent female and 41 percent were aged between 18 and 24. On May 27, the film took an additional $30.0 million, dropping only 5 percent from the takings of the previous day and becoming the highest-grossing Friday for a live-action comedy. The three-day (Friday–Sunday) opening weekend accumulated $85,946,294—an average of $23,923 per theater—becoming the highest-grossing opening weekend for a comedy film, replacing "The Simpsons Movie" ($74 million), the highest-grossing opening weekend for a live-action comedy, replacing "Austin Powers in Goldmember" ($73 million), the highest-grossing opening weekend for an R-rated comedy, replacing "Sex and the City" ($79 million)