Pandemic smallpox was responsible for 300–500 million deaths. As recently as the early 1950s, an estimated 50 million cases of smallpox occurred in the world each year. After successful vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in December 1979. To this day, smallpox is the only human infectious disease to have been completely eradicated, and one of two infectious viruses ever to be eradicated. Historically, measles was prevalent throughout the world, as it is highly contagious. According to the U.S. National Immunization Program, 90% of people were infected with measles by age 15.
Human extinction Ken Olum, Joshua Knobe, and Alexander Vilenkin the possibility of human extinction "does" have practical implications. For instance, if the "universal" Doomsday argument is accepted it changes the most likely source of disasters, and hence the most efficient means of preventing them. They write: "... you should be more concerned that a large number of asteroids have not yet been detected than about the particular orbit of each one. You should not worry especially about the chance that some specific nearby star will become a supernova, but more about the chance that supernovas are more deadly to nearby life than