AC Omonia was then accepted by the Cyprus Football Association to participate in the Cypriot First Division After joining the Cypriot First Division in 1953, Omonia only placed seventh out of nine teams in the 1953–54 season, barely avoiding relegation. During that decade, the club's best placing came during the 1956–57 season when the club finished in the third position. The team would make its closest push for the title during the 1959–60 season after finishing second, one point behind Anorthosis Famagusta. The following year, after seven seasons in the First Division, the club would win its first title in 1960–61 season.
Anorthosis Famagusta FC in European football next day swept Larnaca airport deifying their "fallen hero" of Bucharest. Uefa Cup 1992–93: In 1992–93 the team participated again in the UEFA Cup. Dreams dashed any discrimination on hearing the draw that brought us face to face with the Other "Old Lady" the famous Juventus. With giants from the world of world football like Roberto Baggio, Vialli, Ravanelli, Cashiragi, Peruzzi, Torriceli, Moller, Julio Cesar, Kohler and under the guidance of Trapatoni subsequent holder of the trophy summarily whacked Anorthosis defeating them 6–1 in Turin and 0–4 at the Antonis Papadopoulos. The titular goal of Anorthosis noted Ketsbaia and coach