The Hangover Part II an exotic location. That's all I know". In January 2010, Phillips dismissed rumors that Zac Efron would join the cast of "The Hangover 2", though Ed Helms stated that Efron would be a welcomed addition, commenting, "I love that guy. He's actually really funny". In March 2010, Phillips denied reports that the film would take place in Mexico or Thailand stating, "I don't know. There's a lot of rumors. There was rumor also that it was going to Mexico or something and neither are true". Also by March, Galifianakis, Helms, Bradley Cooper, and Justin Bartha completed negotiations and signed deals
The Hangover Part II audience was 51 percent female and 41 percent were aged between 18 and 24. On May 27, the film took an additional $30.0 million, dropping only 5 percent from the takings of the previous day and becoming the highest-grossing Friday for a live-action comedy. The three-day (Friday–Sunday) opening weekend accumulated $85,946,294—an average of $23,923 per theater—becoming the highest-grossing opening weekend for a comedy film, replacing "The Simpsons Movie" ($74 million), the highest-grossing opening weekend for a live-action comedy, replacing "Austin Powers in Goldmember" ($73 million), the highest-grossing opening weekend for an R-rated comedy, replacing "Sex and the City" ($79 million)