Aurora Borealis (film) Aurora Borealis (film) Aurora Borealis is a 2005 romantic drama film directed by James C.E. Burke and starring Joshua Jackson, Donald Sutherland, Juliette Lewis, and Louise Fletcher. The film was produced between November 3-December 19, 2003. Duncan (Joshua Jackson) is an unemployed youth, trying to cope with the death of his father ten years ago. The film is set in Minneapolis, Minnesota. Duncan's grandparents, Ronald (Donald Sutherland) and Ruth (Louise Fletcher) move into an apartment with a very nice view. Ron claims that he has seen the Northern Lights "aka" Aurora Borealis from the balcony. Ron is fast deteriorating with
Aurora inhibitor so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have gained a great deal of attention as possible anticancer drug targets. The Aurora enzymes are particularly significant because they are involved in a direct path to the nucleosome by phosphorylating histone H3. Furthermore, Aurora kinases are known to be oncogenic and overexpressed in various forms of cancerous growth, including leukemia, colon cancer, prostate cancer and breast cancer tumors. So far three Aurora-kinase inhibitors have been described: ZM447439, Hesperadin and VX-680. The last is in advanced stages (Phase II clinical trial) of a joint drug