Primary polydipsia the response of the kidneys to vasopressin, thus reducing the kidney's ability to concentrate the urine. This means that psychogenic polydipsia may lead to test results (e.g. in a water restriction test) consistent with diabetes insipidus or SIADH, leading to misdiagnosis. Dry mouth is often a side effect of medications used in the treatment of some mental disorders, rather than being caused by the underlying condition. Such medications include antipsychotics, antidepressants, anticonvulsants, alpha agonists and anticholinergics. It should also be ensured that the thirst isn't caused by diuretic use (particularly thiazide diuretics), MDMA use, excessive solute intake or chronic alcoholism.
Polydipsia in birds has been experimentally induced in pigeons, budgerigars and ducks, by the administration of lithium chloride (LiCl). The polydipsic effect was greatest in budgerigars, a desert-dwelling species with a well-developed fluid retention system, and least in ducks, a species with an efficient sodium-secretion system. In waterfowl, polydipsia can be a symptom of duck virus enteritis. Polydipsia has also been listed as a symptom of many diseases, including In hens, lesions of the supraoptic hypothalamus of the brain can result in polydipsia. Polydipsia sometimes occurs under housing or experimental conditions which purportedly lead to stress or frustration. Growing parent stock of meat-type