AC Omonia was then accepted by the Cyprus Football Association to participate in the Cypriot First Division After joining the Cypriot First Division in 1953, Omonia only placed seventh out of nine teams in the 1953–54 season, barely avoiding relegation. During that decade, the club's best placing came during the 1956–57 season when the club finished in the third position. The team would make its closest push for the title during the 1959–60 season after finishing second, one point behind Anorthosis Famagusta. The following year, after seven seasons in the First Division, the club would win its first title in 1960–61 season.
2011–12 Anorthosis Famagusta F.C. season made it 1–1 and gave to Anorthosis the 1 point. At Match day 3 Anorthosis went to Tasos Markou to play against Enosis Paralimni on September 17. Anorthosis players found their way to the nets on the 69th minute with the goal of Bojan Markovski after a smart kickoff of Marko Andić from the left side. Players of Anorthosis lost many opportunities to score another goal after the red card which Kiassos received. In the final stages of the match threatened to take up the equalizer causing the murmur of the fans and complaints about the fairness of the victory