The Hangover Part II takes no chances and opts for a safe, subdued pre-wedding brunch. Things do not go as planned, resulting in another bad hangover with no memories of the previous night. Development began in April 2009, two months before "The Hangover" was released. The principal actors were cast in March 2010 to reprise their roles from the first film. Production began in October 2010, in Ontario, California, before moving on location in Thailand. The film was released on May 26, 2011 and became the highest-grossing R-rated comedy during its theatrical run. A third and final installment, "The Hangover Part III", was released
The Hangover Part II audience was 51 percent female and 41 percent were aged between 18 and 24. On May 27, the film took an additional $30.0 million, dropping only 5 percent from the takings of the previous day and becoming the highest-grossing Friday for a live-action comedy. The three-day (Friday–Sunday) opening weekend accumulated $85,946,294—an average of $23,923 per theater—becoming the highest-grossing opening weekend for a comedy film, replacing "The Simpsons Movie" ($74 million), the highest-grossing opening weekend for a live-action comedy, replacing "Austin Powers in Goldmember" ($73 million), the highest-grossing opening weekend for an R-rated comedy, replacing "Sex and the City" ($79 million)