AC Omonia was then accepted by the Cyprus Football Association to participate in the Cypriot First Division After joining the Cypriot First Division in 1953, Omonia only placed seventh out of nine teams in the 1953–54 season, barely avoiding relegation. During that decade, the club's best placing came during the 1956–57 season when the club finished in the third position. The team would make its closest push for the title during the 1959–60 season after finishing second, one point behind Anorthosis Famagusta. The following year, after seven seasons in the First Division, the club would win its first title in 1960–61 season.
Anorthosis Famagusta FC in European football the Georgian Club 2–0 in Zestafoni. In the third qualifying round Anorthosis encountered FK Rabotnički Skopje. The first match at Antonis Papadopoulos Stadium was not the ideal for the Cypriot club, after the first 70 minutes the result was still 0–0. The Skopje Club scored in their first real opportunity in the game, after another 10 minutes the Skopje club scored a second goal after an incredible mistake by the Anorthosis' goalkeeper Dimitar Ivankov. In the second match at the Philip II Arena Anorthosis won 1–2 FK Rabotnički. The score 0–2 until 87-minute,which would send the game to extra-time. After