Pandemic smallpox was responsible for 300–500 million deaths. As recently as the early 1950s, an estimated 50 million cases of smallpox occurred in the world each year. After successful vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in December 1979. To this day, smallpox is the only human infectious disease to have been completely eradicated, and one of two infectious viruses ever to be eradicated. Historically, measles was prevalent throughout the world, as it is highly contagious. According to the U.S. National Immunization Program, 90% of people were infected with measles by age 15.
Human extinction was highly debated in the 19th century in the form of devolution and degeneration. Because human extinction is unprecedented, speculation about the probability of different scenarios is highly subjective. Nick Bostrom argues that it would be "misguided" to assume that the probability of near-term extinction is less than 25% and that it will be "a tall order" for the human race to "get our precautions sufficiently right the first time", given that an existential risk provides no opportunity to learn from failure. A little more optimistically, philosopher John Leslie assigns a 70% chance of humanity surviving the next five centuries,