AC Omonia was then accepted by the Cyprus Football Association to participate in the Cypriot First Division After joining the Cypriot First Division in 1953, Omonia only placed seventh out of nine teams in the 1953–54 season, barely avoiding relegation. During that decade, the club's best placing came during the 1956–57 season when the club finished in the third position. The team would make its closest push for the title during the 1959–60 season after finishing second, one point behind Anorthosis Famagusta. The following year, after seven seasons in the First Division, the club would win its first title in 1960–61 season.
2011–12 Anorthosis Famagusta F.C. season of the opposing side. The first classic derby of the season was on the 4th match day. Anorthosis Famagusta welcomed Omonia Nicosia at the Antonis Papadopoulos on September 25. After a good quarter of an hour for Anorthosis, Omonia was one that took the reins of the game and found a chance to open the score with Efrem with the goalkeeper avoids the goal. Shortly afterwards Anorthosis it was the team who lost the opportunities to score with Jan Rezek, Okkas and Roncatto with Antonis Georgallides said in both opportunities "no". At the end of the halftime. Stanislav Angelov lost