Spinone Italiano conducted a breed health survey which found the average life expectancy of Italian Spinone to be 8.7 years. The breed is believed to have been developed in the Piedmont region of Italy. As the Spinone is a very ancient breed (it is believed to be one of the oldest gun dogs in existence), it is not known exactly what the origins of the breed are; there are many different theories. Some of these claim that the Spinone could have originated in Italy, France, Spain, Russia, Greece, or Celtic Ireland. Some people familiar with the history of the breed claim that
Fibronectin type III domain Fibronectin type III domain The Fibronectin type III domain is an evolutionary conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 amino acids long and possesses a beta sandwich structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins. ABI3BP; ANKFN1; ASTN2; AXL; BOC;