AC Omonia was then accepted by the Cyprus Football Association to participate in the Cypriot First Division After joining the Cypriot First Division in 1953, Omonia only placed seventh out of nine teams in the 1953–54 season, barely avoiding relegation. During that decade, the club's best placing came during the 1956–57 season when the club finished in the third position. The team would make its closest push for the title during the 1959–60 season after finishing second, one point behind Anorthosis Famagusta. The following year, after seven seasons in the First Division, the club would win its first title in 1960–61 season.
AC Omonia league championship. After putting the proper pieces in place, Omonia did just that. During the 2009–10 season, led by the new captain, Elias Charalambous, Omonia would not lose a single derby, including play-offs matches against either, APOEL, Anorthosis Famagusta nor Apollon. Head coach Takis Lemonis left the club after disappointing results and Dušan Bajević became the new coach in October 2010, but was fired in April 2011. He was replaced by Neophytos Larkou. Omonia would not be able to repeat as Champion during the 2010–11 regular season, and instead had to settle with finishing second, despite the addition of yet