Primary polydipsia Alcoholism may cause physiological thirst since ethanol inhibits vasopressin, the hormone primarily responsible for water retention in osmoregulation. The following conditions should also be excluded: DI, cerebral salt wasting, pseudohyponatraemia caused by hyperlipidemia or hyperparaproteinemia, SIADH, mineralcorticoid deficiency, salt-wasting nephropathy, nephrotic syndrome, chronic heart failure and cirrhosis. Tobacco smoking is an often overlooked factor linked to hyponatremia, due to the ADH-releasing effect of nicotine, although this is usually limited to heavy smokers. One study suggested that around 70% of patients with self-induced polydipsia were tobacco smokers. Diagnostic tests for primary polydipsia usually involves the fluid deprivation test to exclude ADH
Medical literature of medical knowledge was far surpassing the capacity of any single individual to encompass". Since that time, this has been the standard. Examples are: Harrison's "Principal of Internal Medicine" is widely considered the most read textbook of medicine ever. It was able to eclipse Cecil's by changing the organization. Instead of organizing by disease, Tinsley Harrison organized the book by region and symptom, allowing students to learn the myriad causes of a patient's symptom, without first knowing the specific disease. Harrison's is also credited for a strong commitment to linking basic science to clinical medicine. Health-related information is often disseminated