AC Omonia was then accepted by the Cyprus Football Association to participate in the Cypriot First Division After joining the Cypriot First Division in 1953, Omonia only placed seventh out of nine teams in the 1953–54 season, barely avoiding relegation. During that decade, the club's best placing came during the 1956–57 season when the club finished in the third position. The team would make its closest push for the title during the 1959–60 season after finishing second, one point behind Anorthosis Famagusta. The following year, after seven seasons in the First Division, the club would win its first title in 1960–61 season.
2013–14 Anorthosis Famagusta F.C. season re signing of Toni Calvo for a year. On 30 August, Anorthosis announces the consensual termination of cooperation with the Brazilian footballer Marcinho. On 2 September, Anorthosis announced the signing of Argentine goalkeeper, Mario Daniel Vega for a season from River Plate. Anorthosis-Omonia: (3–1) On 31 August, With Roberto Colautti to score twice, Anorthosis took the first derby of the season, with rival Omonia, with a 3−1 victory in Antonis Papadopoulos Stadium. First win for Jorge Costa on the bench of Anorthosis. Originally Anorthosis opened the score with Jason Demetriou at 62' and take the victory with Colautti to score