The Net (substance) The Net (substance) The Net, in alchemy, is an alloy of copper and iron, whose crystal structure induces a network pattern on its surface. It was described in the 17th century by Sir Isaac Newton. Newton produced the substance by following what he regarded as a recipe, encoded in classical mythology, for part of the process of achieving the philosopher's stone. The relevant myth involved the god Vulcan finding his wife Venus (alchemical symbol for copper) in bed with the god Mars (alchemical symbol for iron) Newton's interpretation rested on typical alchemical associations, construing Vulcan as a stand-in for fire,
Substance P The sensory function of substance P is thought to be related to the transmission of pain information into the central nervous system. Substance P coexists with the excitatory neurotransmitter glutamate in primary afferents that respond to painful stimulation. Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, muscle, and joints. It is proposed that this release is involved in neurogenic inflammation, which is a local inflammatory response to certain types of infection or injury. Unfortunately, the reasons why NK1RAs have failed as efficacious analgesics in well-conducted clinical proof of