Spinone Italiano Spinone Italiano The Spinone Italiano () is an Italian dog breed. It was originally bred as a versatile gun dog. To this day, the breed is still a capable dog for that purpose. The Spinone is a loyal, friendly and alert dog with a close lying, wiry coat. It is an ancient breed that can be traced back to approximately 500 BC. It is traditionally used for hunting, pointing, and retrieving game (HPR), but, in addition to that purpose, the intelligent and strong Spinone may be practically anything ranging from a companion to an assistance dog. The Spinone has a
Fibronectin type III domain Fibronectin type III domain The Fibronectin type III domain is an evolutionary conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 amino acids long and possesses a beta sandwich structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins. ABI3BP; ANKFN1; ASTN2; AXL; BOC;