Primary polydipsia Alcoholism may cause physiological thirst since ethanol inhibits vasopressin, the hormone primarily responsible for water retention in osmoregulation. The following conditions should also be excluded: DI, cerebral salt wasting, pseudohyponatraemia caused by hyperlipidemia or hyperparaproteinemia, SIADH, mineralcorticoid deficiency, salt-wasting nephropathy, nephrotic syndrome, chronic heart failure and cirrhosis. Tobacco smoking is an often overlooked factor linked to hyponatremia, due to the ADH-releasing effect of nicotine, although this is usually limited to heavy smokers. One study suggested that around 70% of patients with self-induced polydipsia were tobacco smokers. Diagnostic tests for primary polydipsia usually involves the fluid deprivation test to exclude ADH
Patient Health Questionnaire sensitivity but poor specificity. The Patient Health Questionnaire 4 item (PHQ-4) combines the PHQ-2 with the Generalized Anxiety Disorder 2 (GAD-2), an ultra-brief anxiety screener containing the first two questions from the Generalized Anxiety Disorder 7 (GAD-7). The Patient Health Questionnaire 15 item (PHQ-15) contains the PHQ's somatic symptom scale. It is a well-validated measure, which asks whether symptoms are present and about their severity. A brief version, the Somatic Symptom Scale - 8 was derived from PHQ-15. The development of the PHQ-15 helped address three main problems in the assessment and diagnosis of somatoform disorders. Firstly, traditional methods of