The Hangover Part II an exotic location. That's all I know". In January 2010, Phillips dismissed rumors that Zac Efron would join the cast of "The Hangover 2", though Ed Helms stated that Efron would be a welcomed addition, commenting, "I love that guy. He's actually really funny". In March 2010, Phillips denied reports that the film would take place in Mexico or Thailand stating, "I don't know. There's a lot of rumors. There was rumor also that it was going to Mexico or something and neither are true". Also by March, Galifianakis, Helms, Bradley Cooper, and Justin Bartha completed negotiations and signed deals
The Hangover Part II and the second-highest-grossing opening weekend of all time for an R-rated film, behind "The Matrix Reloaded" ($91.7 million). For the Memorial Day four-day weekend, the film amassed $103.4 million to become the fourth-highest-grossing Memorial Day weekend opening. In its second weekend the film gross dropped 64 percent from the previous weekend—while the original film dropped only 27 percent during its second weekend—and grossed $31.4 million. The film ended its box office run on September 15, 2011, on 113th day of its release. "The Hangover Part II" debuted in 40 countries internationally over the weekend of May 26–29, 2011, across 5,170