Pandemic smallpox was responsible for 300–500 million deaths. As recently as the early 1950s, an estimated 50 million cases of smallpox occurred in the world each year. After successful vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in December 1979. To this day, smallpox is the only human infectious disease to have been completely eradicated, and one of two infectious viruses ever to be eradicated. Historically, measles was prevalent throughout the world, as it is highly contagious. According to the U.S. National Immunization Program, 90% of people were infected with measles by age 15.
Human extinction biotechnology or self-replicating nanobots. The probability of anthropogenic human extinction within the next hundred years is the topic of an active debate. Human extinction needs to be differentiated from the extinction of all life on Earth (see also future of Earth) and from the extinction of major components of human culture (e.g., through a global catastrophe leaving only small, scattered human populations, which might evolve in isolation). "Existential risks" are risks that threaten the entire future of humanity, whether by causing human extinction or by otherwise permanently crippling human progress. Many scholars make an argument based on the size of