Lockheed CP-140 Aurora Lockheed CP-140 Aurora The Lockheed CP-140 Aurora is a maritime patrol aircraft operated by the Royal Canadian Air Force. The aircraft is based on the Lockheed P-3 Orion airframe, but mounts the electronics suite of the Lockheed S-3 Viking. "Aurora" refers to the Roman goddess of dawn who flies across the sky each morning ahead of the sun. Aurora also refers to the Aurora Borealis, the "northern lights", that are prominent over northern Canada and the Arctic Ocean. The CP-140A Arcturus was a related variant used primarily for pilot training and coastal surface patrol missions. The CP-140 Aurora is very
Aurora inhibitor so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have gained a great deal of attention as possible anticancer drug targets. The Aurora enzymes are particularly significant because they are involved in a direct path to the nucleosome by phosphorylating histone H3. Furthermore, Aurora kinases are known to be oncogenic and overexpressed in various forms of cancerous growth, including leukemia, colon cancer, prostate cancer and breast cancer tumors. So far three Aurora-kinase inhibitors have been described: ZM447439, Hesperadin and VX-680. The last is in advanced stages (Phase II clinical trial) of a joint drug