Tuberculosis in human culture the disease, which allegedly helped them to see life more clearly and to act decisively. In 1680 John Bunyan referred to it as "the captain of all these men of death". Several major operas have exploited the theme of heroines dying tragically of tuberculosis, including Mimì in Puccini's opera "La bohème". Giuseppe Verdi's "La Traviata" features the consumptive Violetta Valéry, based on Marguerite Gautier in Alexandre Dumas, "fils"'s 1848 novel "La Dame aux Camélias". In Jacques Offenbach's opera "The Tales of Hoffmann", Antonia has tuberculosis and is under the control of a Svengali-like quack doctor who forces her to sing
La Chapelle-aux-Saints 1 of Neanderthal anatomy based on la Chapelle-aux-Saints material shaped popular perceptions of the Neanderthals for over thirty years. The La Chapelle-aux-Saints specimen is typical of "classic" Western European Neanderthal anatomy. It is estimated to be about 60,000 years old. Boule's reconstruction of La Chapelle-aux-Saints 1, published during 1911–1913, depicted Neanderthals with a thrust-forward skull, a spine without curvature, bent hips and knees and a divergent big toe. This depiction fit in well with contemporary evolutionary scenarios in which Neanderthals were not considered to be direct ancestors of modern humans (the relationship of Neanderthals to modern humans remains a major debate