Tuberculosis in human culture the disease, which allegedly helped them to see life more clearly and to act decisively. In 1680 John Bunyan referred to it as "the captain of all these men of death". Several major operas have exploited the theme of heroines dying tragically of tuberculosis, including Mimì in Puccini's opera "La bohème". Giuseppe Verdi's "La Traviata" features the consumptive Violetta Valéry, based on Marguerite Gautier in Alexandre Dumas, "fils"'s 1848 novel "La Dame aux Camélias". In Jacques Offenbach's opera "The Tales of Hoffmann", Antonia has tuberculosis and is under the control of a Svengali-like quack doctor who forces her to sing
Giuseppe Verdi and Strepponi left Paris in July 1849, the immediate cause being an outbreak of cholera, and Verdi went directly to Busseto to continue work on completing his latest opera, "Luisa Miller", for a production in Naples later in the year. Verdi was committed to the publisher Giovanni Ricordi for an opera—which became "Stiffelio"—for Trieste in the Spring of 1850; and, subsequently, following negotiations with La Fenice, developed a libretto with Piave and wrote the music for "Rigoletto" (based on Victor Hugo's "Le roi s'amuse") for Venice in March 1851. This was the first of a sequence of three operas (followed