Gene therapy of the human retina reduction may lead to the development of AMD. In animal model, an AAV with human PEDF cDNA under the control of the CMV promoter prevented choroidal and retinal NV ( 24). The finding suggests that the AAV-mediated expression of angiostatic factors can be implemented to treat NV. This approach could be useful as an alternative to frequent injections of recombinant protein into the eye. In addition, PEDF and sFlt-1 may be able to diffuse through sclera tissue, allowing for the potential to be relatively independent of the intraocular site of administration. Gene therapy of the human retina Retinal gene therapy
Effect of spaceflight on the human body as with previous stations and spacecraft, and may not suffer from feelings of isolation in the same way. The sum of human experience has resulted in the accumulation of 58 solar years in space and a much better understanding of how the human body adapts. In the future, industrialisation of space and exploration of inner and outer planets will require humans to endure longer and longer periods in space. The majority of current data comes from missions of short duration and so some of the long-term physiological effects of living in space are still unknown. A round trip to Mars