Gene therapy of the human retina reduction may lead to the development of AMD. In animal model, an AAV with human PEDF cDNA under the control of the CMV promoter prevented choroidal and retinal NV ( 24). The finding suggests that the AAV-mediated expression of angiostatic factors can be implemented to treat NV. This approach could be useful as an alternative to frequent injections of recombinant protein into the eye. In addition, PEDF and sFlt-1 may be able to diffuse through sclera tissue, allowing for the potential to be relatively independent of the intraocular site of administration. Gene therapy of the human retina Retinal gene therapy
The Human Factor (1963 The Outer Limits) The Human Factor (1963 The Outer Limits) "The Human Factor" is an episode of the original "The Outer Limits" television show. It first aired on 11 November 1963, during the first season. The title was re-used in 2002 for an episode with an unrelated plot. Doctor James Hamilton develops a device that allows him to experience the thoughts and feelings of another person. At a military outpost in Greenland, Project Engineer Maj. Brothers (Guardino) begins losing his grip on reality - while wrestling with guilt and remorse - after losing one of his soldiers in an icy crevasse. Mentally haunted