History of aspirin History of aspirin The history of aspirin (IUPAC name acetylsalicylic acid ) begins with its synthesis and manufacture in 1899. Before that, salicylic acid had been used medicinally since antiquity. Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to their use of salicylic tea to reduce fevers around 400 BC, and were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. Willow bark extract became recognized for its specific effects on fever, pain and inflammation in the
Bark bread known from the 1890s, and in Finland "pettuleipä" (literally "pinewood-bark bread") was produced as ersatz bread during the Finnish Civil War of 1918. Finger sized twigs and branches were collected from deciduous trees and shrubs, and the bark split and the inner bark (the phloem and sometimes the vascular cambium) collected while still fresh. The yellow or green inner bark (depending on tree species) was dried over open fire, in an oven or dried in the sun for a few days. A mortar or mill was used to grind the bark to a fine powder to add to the flour.