Gene therapy of the human retina reduction may lead to the development of AMD. In animal model, an AAV with human PEDF cDNA under the control of the CMV promoter prevented choroidal and retinal NV ( 24). The finding suggests that the AAV-mediated expression of angiostatic factors can be implemented to treat NV. This approach could be useful as an alternative to frequent injections of recombinant protein into the eye. In addition, PEDF and sFlt-1 may be able to diffuse through sclera tissue, allowing for the potential to be relatively independent of the intraocular site of administration. Gene therapy of the human retina Retinal gene therapy
The Layer Quaternity The Layer Quaternity The Layer Quaternity are four marble sculpture figurines approximately in height located on the two columns of the Layer Monument, an early 17th-century polychrome mural monument () which was installed in the Church of Saint John the Baptist, Maddermarket, Norwich to the memory of Christopher Layer (1531–1600). The quartet of figurines sculptured in marble, "Pax, Gloria, Vanity, Labor" exhibit primary thematic concerns and stylistic attributes of Northern Mannerist art, namely, portraiture of animated human movement, variety and multiplicity, often set in the Classical or mythological world, and inclined towards esoteric concepts. The Layer Quaternity ("circa" 1598–1604) share