Gene therapy of the human retina reduction may lead to the development of AMD. In animal model, an AAV with human PEDF cDNA under the control of the CMV promoter prevented choroidal and retinal NV ( 24). The finding suggests that the AAV-mediated expression of angiostatic factors can be implemented to treat NV. This approach could be useful as an alternative to frequent injections of recombinant protein into the eye. In addition, PEDF and sFlt-1 may be able to diffuse through sclera tissue, allowing for the potential to be relatively independent of the intraocular site of administration. Gene therapy of the human retina Retinal gene therapy
Development of the human body characteristics, the "filling in" of the child's body; from girl to woman, from boy to man. Biologically, an adult is a human or other organism that has reached sexual maturity. In human context, the term "adult" additionally has meanings associated with social and legal concepts. In contrast to a "minor", a legal adult is a person who has attained the age of majority and is therefore regarded as independent, self-sufficient, and responsible. The typical age of attaining adulthood is 18, although definition may vary by legal rights and country. Human adulthood encompasses psychological adult development. Definitions of adulthood are often