Gene therapy of the human retina reduction may lead to the development of AMD. In animal model, an AAV with human PEDF cDNA under the control of the CMV promoter prevented choroidal and retinal NV ( 24). The finding suggests that the AAV-mediated expression of angiostatic factors can be implemented to treat NV. This approach could be useful as an alternative to frequent injections of recombinant protein into the eye. In addition, PEDF and sFlt-1 may be able to diffuse through sclera tissue, allowing for the potential to be relatively independent of the intraocular site of administration. Gene therapy of the human retina Retinal gene therapy
Development of the human cerebral cortex in this area is where neurons, that are created in the ventricular zone, migrate through in order to reach the cortical plate. This zone is only present during corticogenesis and eventually transforms into adult white matter. The ventricular and subventricular zones exist below the intermediate zone and communicate to other zones through cell signalling, also creating neurons destined to migrate to other areas in the cortex. The marginal zone, along with the cortical zone, make up the 6 layers that form the cortex. This zone is the predecessor for layer 1 of the cortex. Astrocytes form an outer limiting membrane