Charles Alexander, Margrave of Brandenburg-Ansbach Charles Alexander, Margrave of Brandenburg-Ansbach Christian Frederick Charles Alexander (; 24 February 1736 – 5 January 1806) was the last Margrave of the two Franconian principalities, Brandenburg-Ansbach and Brandenburg-Bayreuth, which he sold to the King of Prussia, a fellow member of the House of Hohenzollern. His parents were Charles William Frederick, Margrave of Brandenburg-Ansbach, and Friederike Luise of Prussia, daughter of King Frederick William I of Prussia, sister of Frederick II of Prussia, a granddaughter of the British King George I and niece of the reigning British King George II (who would die aged 77 and leave his grandson, Charles's
Caroline of Ansbach physics discussion of the 18th century. She helped to popularise the practice of variolation (an early type of immunisation), which had been witnessed by Lady Mary Wortley Montagu and Charles Maitland in Constantinople. At the direction of Caroline, six condemned prisoners were offered the chance to undergo variolation instead of execution: they all survived, as did six orphan children given the same treatment as a further test. Convinced of its medical value, Caroline had her children Amelia, Caroline and Frederick inoculated against smallpox in the same manner. In praising her support for smallpox inoculation, Voltaire wrote of her, "I must