Tree from the cinchona tree ("Cinchona") and was for a long time the remedy of choice for the treatment of malaria. Aspirin was synthesised to replace the sodium salicylate derived from the bark of willow trees ("Salix") which had unpleasant side effects. The anti-cancer drug Paclitaxel is derived from taxol, a substance found in the bark of the Pacific yew ("Taxus brevifolia"). Other tree based drugs come from the paw-paw ("Carica papaya"), the cassia ("Cassia spp."), the cocoa tree ("Theobroma cacao"), the tree of life ("Camptotheca acuminata") and the downy birch ("Betula pubescens"). The papery bark of the white birch tree
History of aspirin as the Great Phenol Plot. By 1915, the price of phenol rose to the point that Bayer's aspirin plant was forced to drastically cut production. This was especially problematic because Bayer was instituting a new branding strategy in preparation of the expiry of the aspirin patent in the United States. Thomas Edison, who needed phenol to manufacture phonograph records, was also facing supply problems; in response, he created a phenol factory capable of pumping out twelve tons per day. Edison's excess phenol seemed destined for trinitrophenol production. Although the United States remained officially neutral until April 1917, it was increasingly