William Frederick, Margrave of Brandenburg-Ansbach in Unterreichenbach and was succeeded by his son Charles William Frederick, called "The Wild Margrave". William Frederick, Margrave of Brandenburg-Ansbach William Frederick, Margrave of Brandenburg-Ansbach (8 January 1686 – 7 January 1723), was Margrave of the Principality of Brandenburg-Ansbach from 1703 until his death in 1723. He was the younger brother of Caroline of Ansbach and thus brother-in-law of George II of Great Britain. William Frederick was born in Ansbach in 1686 to John Frederick, Margrave of Brandenburg-Ansbach, and his second wife, Eleonore Erdmuthe of Saxe-Eisenach. His two surviving half-brothers, Margraves Christian Albert and George Frederick II, both died unmarried
Caroline of Ansbach physics discussion of the 18th century. She helped to popularise the practice of variolation (an early type of immunisation), which had been witnessed by Lady Mary Wortley Montagu and Charles Maitland in Constantinople. At the direction of Caroline, six condemned prisoners were offered the chance to undergo variolation instead of execution: they all survived, as did six orphan children given the same treatment as a further test. Convinced of its medical value, Caroline had her children Amelia, Caroline and Frederick inoculated against smallpox in the same manner. In praising her support for smallpox inoculation, Voltaire wrote of her, "I must