Princess Caroline of Gloucester Princess Caroline of Gloucester Princess Caroline of Gloucester (Caroline Augusta Maria; 24 June 177414 March 1775) was an infant member of the British Royal Family, a great-grandchild of George II, niece of George III and daughter of the 1st Duke of Gloucester and Edinburgh and his wife, Maria Walpole, daughter of Sir Edward Walpole and his mistress Dorothy Clement. Princess Caroline was born at Gloucester House, Piccadilly Street, London. Her father was the 1st Duke of Gloucester and Edinburgh, eldest son of the Prince of Wales. Her mother was the 1st Duchess of Gloucester and Edinburgh (previously the Countess Waldrave),
Caroline of Ansbach physics discussion of the 18th century. She helped to popularise the practice of variolation (an early type of immunisation), which had been witnessed by Lady Mary Wortley Montagu and Charles Maitland in Constantinople. At the direction of Caroline, six condemned prisoners were offered the chance to undergo variolation instead of execution: they all survived, as did six orphan children given the same treatment as a further test. Convinced of its medical value, Caroline had her children Amelia, Caroline and Frederick inoculated against smallpox in the same manner. In praising her support for smallpox inoculation, Voltaire wrote of her, "I must