Decline of the Byzantine Empire of Constantinople in 1453. The process by which the empire waned, and from when its decline can be traced, is a matter of scholarly debate. In some cases, the entire history of the Byzantine Empire has been portrayed as a protracted period of decline of the Roman Empire. This holds especially for Enlightenment era writers such as Edward Gibbon, author of "The History of the Decline and Fall of the Roman Empire", published in six volumes between 1776 and 1789, whose view was coloured by pro-western or anti-clerical biases, and tended to see the whole ten-century empire as merely a
Historiography of the fall of the Western Roman Empire launched by the Eastern Emperor Justinian in the 6th century, and meant to reunite the Empire, that eventually caused the most damage to Italy, as well as straining the Eastern Empire militarily. Following these wars, Rome and other Italian cities would fall into severe decline (Rome itself was almost completely abandoned). Another blow came with the Persian invasion of the East in the 7th century, immediately followed by the Muslim conquests, especially of Egypt, which curtailed much of the key trade in the Mediterranean on which Europe depended. The Empire was to live on in the East for many centuries,