History of aspirin tree in 1758 and noticed an astringency reminiscent of the standard—and expensive—ague cure of Peruvian bark. He collected, dried, and powdered a substantial amount of willow bark, and over the next five years tested it on a number of people sick with fever and agues. In his letter, Stone reported consistent success, describing willow extract's effects as identical to Peruvian bark, though a little less potent. (In fact, the active ingredient of Peruvian bark was quinine, which attacked the infectious cause of malaria, while the active ingredient of willow extract, salicin, relieved the symptoms of malaria but could not cure
Bark at the Moon new remix of the album. This 2002 remixed version of the album was met with mixed reaction; many elements found in the original mix are not present in the remix, namely several lead guitar parts. In addition, the song "You're No Different" has an alternate ending (with the fade-out removed) and "Centre of Eternity" has an altered intro segment. This edition also included the bonus tracks "Spiders" and "One Up the 'B' Side", originally the B-side of the "Bark at the Moon" single. All lyrics and music by Ozzy Osbourne, Jake E. Lee, and Bob Daisley Bark at the Moon