History of aspirin other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases. Aspirin sales revived considerably in the last decades of the twentieth century, and remain strong in the twenty-first with widespread use as a preventive treatment for heart attacks and strokes. Medicines derived from willow trees and other salicylate-rich plants have been part of pharmacopoeias at least dating back to ancient Sumer. The Ebers Papyrus, an Egyptian medical text from ca. 1543 BCE, mentions use of willow and myrtle (another salicylate-rich plant) to treat fever and pain. Willow bark
Bark at the Moon new remix of the album. This 2002 remixed version of the album was met with mixed reaction; many elements found in the original mix are not present in the remix, namely several lead guitar parts. In addition, the song "You're No Different" has an alternate ending (with the fade-out removed) and "Centre of Eternity" has an altered intro segment. This edition also included the bonus tracks "Spiders" and "One Up the 'B' Side", originally the B-side of the "Bark at the Moon" single. All lyrics and music by Ozzy Osbourne, Jake E. Lee, and Bob Daisley Bark at the Moon