History of aspirin other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases. Aspirin sales revived considerably in the last decades of the twentieth century, and remain strong in the twenty-first with widespread use as a preventive treatment for heart attacks and strokes. Medicines derived from willow trees and other salicylate-rich plants have been part of pharmacopoeias at least dating back to ancient Sumer. The Ebers Papyrus, an Egyptian medical text from ca. 1543 BCE, mentions use of willow and myrtle (another salicylate-rich plant) to treat fever and pain. Willow bark
Bark at the Moon feature drummer Tommy Aldridge, who was a fixture of Osbourne's live band for several years in the early to mid-1980s. He was fired after the recording of the album and briefly replaced by Carmine Appice, but returned mid-tour after Appice was removed by the Osbournes. When asked why Aldridge was brought back, Osbourne told "Hit Parader" magazine in early 1984 "For health reasons. He (Appice) was making me sick." Nonetheless, Appice did appear in the popular music video for the "Bark at the Moon" single. "Bark at the Moon" was re-issued again in 2002, although this version was actually a