Acids in wine ripened grapes. While concentration varies among grape varieties, it is usually found in higher levels with red wine grapes. The acid is created as a byproduct of the metabolization of nitrogen by yeast cells during fermentation. The combination of succinic acid with one molecule of ethanol will create the ester mono-ethyl succinate responsible for a mild, fruit aroma in wines. Acidity is highest in wine grapes just before the start of "veraison", which ushers in the ripening period of the annual cycle of grape vines. As the grapes ripen, their sugar levels increase and their acidity levels decrease. Through the
Wine in China "materia medica" compiled in the late Han, states that grapes could be used to produce wine. In the Three Kingdoms era (220–280 AD), Wei emperor Cao Pi noted that grape wine "is sweeter than the wine made [from cereals] using ferments and sprouted grain. One recovers from it more easily when one has taken too much." Grapes continued to be grown in the following centuries, notably in the northwestern region of Gansu, but were not used to produce wine on a large scale. Wine thus remained an exotic product known by few people. Not until the Tang dynasty (618–907) did