Tree from the cinchona tree ("Cinchona") and was for a long time the remedy of choice for the treatment of malaria. Aspirin was synthesised to replace the sodium salicylate derived from the bark of willow trees ("Salix") which had unpleasant side effects. The anti-cancer drug Paclitaxel is derived from taxol, a substance found in the bark of the Pacific yew ("Taxus brevifolia"). Other tree based drugs come from the paw-paw ("Carica papaya"), the cassia ("Cassia spp."), the cocoa tree ("Theobroma cacao"), the tree of life ("Camptotheca acuminata") and the downy birch ("Betula pubescens"). The papery bark of the white birch tree
Mechanism of action of aspirin are required to attain further inhibition. A side-effect of aspirin mechanism is that the ability of the blood in general to clot is reduced, and excessive bleeding may result from the use of aspirin. Aspirin has been shown to have three additional modes of action. It uncouples oxidative phosphorylation in cartilaginous (and hepatic) mitochondria, by diffusing from the intermembrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons. In short, aspirin buffers and transports the protons, acting as a competitor to ATP synthase. When high doses of aspirin are given, aspirin