Dorothea Friederike of Brandenburg-Ansbach Dorothea Friederike of Brandenburg-Ansbach Dorothea Friederike of Brandenburg-Ansbach (12 August 1676 – 13 March 1731) was the daughter of Margrave John Frederick of Brandenburg-Ansbach (1654–1686) and his first wife, Margravine Johanna Elisabeth of Baden-Durlach (1651–1680). She was a half-sister of Queen Caroline of Great Britain, the wife of King George II On 20 (or 30) August 1699, Dorothea Friederike Count married Johann Reinhard III of Hanau-Lichtenberg. She was the last Countess of Hanau. The marriage produced one daughter: Charlotte Christine Magdalene Johanna (1700–1726). Charlotte was the sole heiress of the county of Hanau and married on 5 April 1717 Crown
Caroline of Ansbach physics discussion of the 18th century. She helped to popularise the practice of variolation (an early type of immunisation), which had been witnessed by Lady Mary Wortley Montagu and Charles Maitland in Constantinople. At the direction of Caroline, six condemned prisoners were offered the chance to undergo variolation instead of execution: they all survived, as did six orphan children given the same treatment as a further test. Convinced of its medical value, Caroline had her children Amelia, Caroline and Frederick inoculated against smallpox in the same manner. In praising her support for smallpox inoculation, Voltaire wrote of her, "I must