Outer plexiform layer not receiving a light signal. Outer plexiform layer The outer plexiform layer (external plexiform layer) is a layer of neuronal synapses in the retina of the eye. It consists of a dense network of synapses between dendrites of horizontal cells from the inner nuclear layer, and photoreceptor cell inner segments from the outer nuclear layer. It is much thinner than the inner plexiform layer, where amacrine cells synapse with retinal ganglion cells. The synapses in the outer plexiform layer are between the rod cell endings or cone cell branched foot plates and horizontal cells. Unlike in most systems, rod and
Gene therapy of the human retina AAV 5 vector containing the wild-type human RSI cDNA driven by a mouse opsin promoter showed long-term retinal functional and structural recovery. Also the retinal structural reliability improved greatly after the treatment, characterized by an increase in the outer nuclear layer thickness. Retinitis pigmentosa is an inherited disease which leads to progressive night blindness and loss of peripheral vision as a result of photoreceptor cell death. Most people who suffer from RP are born with rod cells that are either dead or dysfunctional, so they are effectively blind at nighttime, since these are the cells responsible for vision in low