Culture of South Africa originated in South Africa. The first human-to-human heart transplant was performed by cardiac surgeon Christiaan Barnard at Groote Schuur Hospital in December 1967. Max Theiler developed a vaccine against Yellow Fever, Allan McLeod Cormack pioneered x-ray Computed tomography, and Aaron Klug developed crystallographic electron microscopy techniques. These advancements were all (with the exception of that of Barnard) recognised with Nobel Prizes. Sydney Brenner won most recently, in 2002, for his pioneering work in molecular biology. Mark Shuttleworth founded an early Internet security company Thawte, that was subsequently bought out by world-leader VeriSign. South Africa has cultivated a burgeoning astronomy community.
Arnold Theiler sickness with a combination of live virus and equine antiserum. This disease is now known to be caused by a pegivirus. Theiler was the first Director of the Onderstepoort Veterinary Research Institute, outside Pretoria. This institute under his leadership carried out research on African horse sickness, sleeping sickness, malaria, East Coast fever ("Theileria parva") and tick-borne diseases such as redwater, heartwater and biliary. The University of Pretoria Faculty of Veterinary Science was established there in 1920 which enabled veterinarians to train locally for the first time. Theiler became the first dean of this faculty. He married Emma Sophie Jegge (1861–1951)