Culture of South Africa originated in South Africa. The first human-to-human heart transplant was performed by cardiac surgeon Christiaan Barnard at Groote Schuur Hospital in December 1967. Max Theiler developed a vaccine against Yellow Fever, Allan McLeod Cormack pioneered x-ray Computed tomography, and Aaron Klug developed crystallographic electron microscopy techniques. These advancements were all (with the exception of that of Barnard) recognised with Nobel Prizes. Sydney Brenner won most recently, in 2002, for his pioneering work in molecular biology. Mark Shuttleworth founded an early Internet security company Thawte, that was subsequently bought out by world-leader VeriSign. South Africa has cultivated a burgeoning astronomy community.
Nobel Prize Paul Samuelson and Kenneth Arrow were brothers-in-law. Frits Zernike, who was awarded the 1953 Physics Prize, is the great-uncle of 1999 Physics laureate Gerard 't Hooft. Being a symbol of scientific or literary achievement that is recognisable worldwide, the Nobel Prize is often depicted in fiction. This includes films like "The Prize" and "Nobel Son" about fictional Nobel laureates as well as fictionalised accounts of stories surrounding real prizes such as "Nobel Chor", a film based on the unsolved theft of Rabindranath Tagore's prize. Two laureates have voluntarily declined the Nobel Prize. In 1964, Jean-Paul Sartre was awarded the Literature