Theiler's encephalomyelitis virus Theiler's encephalomyelitis virus Theiler's Murine Encephalomyelitis Virus (TMEV) is a single-stranded RNA murine cardiovirus from the family "Picornaviridae". It has been used as a mouse model for studying virally induced paralysis, as well as encephalomyelitis comparable to Multiple sclerosis. Depending on the mouse and viral strain, viral pathogenesis can range from negligible, to chronic or acute encephalomyelitis. The virus was discovered by virologist Max Theiler in 1937 while working at the Rockefeller Institute. Theiler discovered the encephalomyelitis virus during research on poliovirus-like paralysis symptoms in mice. That year Theiler had completed work on developing a vaccine for Yellow Fever, for
Nobel Prize controversies in his novel, "Doctor Zhivago"." Pasternak died without ever receiving the prize. He was eventually honored by the Nobel Foundation at a banquet in Stockholm on 9 December 1989, when they presented his medal to his son. The 2010 Nobel Peace Prize was awarded to Liu Xiaobo while he was serving a prison sentence for "subversion of the state", with the Chinese government not allowing him or his family members to attend the ceremony. Two laureates voluntarily declined the Nobel Prize. Jean-Paul Sartre declined the 1964 prize for Literature, stating, "A writer must refuse to allow himself to be transformed