Max Theiler health at the Yale School of Medicine and the School of Public Health from 1964 to 1967. After passing the yellow fever virus through laboratory mice, Theiler found that the weakened virus conferred immunity on rhesus macaques. The stage was set for Theiler to develop a vaccine against the disease. Theiler first devised a test for the efficacy of experimental vaccines. In his test, sera from vaccinated human subjects were injected into mice to see if they protected the mice against yellow fever virus. This "mouse protection test" was used with variations as a measure of immunity until after World
Nobel Prize controversies was acceptable for use in humans. No prize was awarded in 1921. Carlos Chagas, who had already been nominated in 1913 and was the recipient of several international awards at the time, was among the nominees. His failure in receiving the award has generated controversy, especially in his homeland, Brazil, proved that Chagas is responsible for one of the most important achievements in the history of parasitology: Chagas alone discovered a new infectious disease, Chagas disease, its pathogen, vector, host, clinical manifestation and epidemology, first describing it in 1909. According to historian Sierra Iglesias, the Nobel Assembly retrieved for Brazilian