Culture of South Africa originated in South Africa. The first human-to-human heart transplant was performed by cardiac surgeon Christiaan Barnard at Groote Schuur Hospital in December 1967. Max Theiler developed a vaccine against Yellow Fever, Allan McLeod Cormack pioneered x-ray Computed tomography, and Aaron Klug developed crystallographic electron microscopy techniques. These advancements were all (with the exception of that of Barnard) recognised with Nobel Prizes. Sydney Brenner won most recently, in 2002, for his pioneering work in molecular biology. Mark Shuttleworth founded an early Internet security company Thawte, that was subsequently bought out by world-leader VeriSign. South Africa has cultivated a burgeoning astronomy community.
Nobel Prize effect it hard for a scientist to work on small problems after winning the prize. During a speech at a seminar, Hamming described a scene at the Nobel awards ceremony as follows: The Nobel Prize effect is also described as a consequence of public perception of the Nobel laureate, magnified by the worldwide exposure the winner experiences. One example is for the Nobel laureate to be treated with reverence due to perception that the laureate has authoritative knowledge about any subject outside the field in which he or she won the prize. Nobel Laureate Klaus von Klitzing describes the effect as