Theiler's encephalomyelitis virus Theiler's encephalomyelitis virus Theiler's Murine Encephalomyelitis Virus (TMEV) is a single-stranded RNA murine cardiovirus from the family "Picornaviridae". It has been used as a mouse model for studying virally induced paralysis, as well as encephalomyelitis comparable to Multiple sclerosis. Depending on the mouse and viral strain, viral pathogenesis can range from negligible, to chronic or acute encephalomyelitis. The virus was discovered by virologist Max Theiler in 1937 while working at the Rockefeller Institute. Theiler discovered the encephalomyelitis virus during research on poliovirus-like paralysis symptoms in mice. That year Theiler had completed work on developing a vaccine for Yellow Fever, for
Nobel Prize controversies possibility is that Nobel did not consider mathematics as a practical discipline. Both the Fields Medal and the Abel Prize have been described as the "Nobel Prize of mathematics". The most notorious controversies have been over prizes for Literature, Peace and Economics. Beyond disputes over which contributor's work was more worthy, critics most often discerned political bias and Eurocentrism in the result. The interpretation of Nobel's original words concerning the Literature prize has also undergone repeated revisions. The 2008 prize was awarded to Osamu Shimomura, Martin Chalfie and Roger Y. Tsien for their work on green fluorescent protein or GFP.