Yellow fever vaccine Foundation to improve the vaccine from the "Asibi" strain, discovered that a favorable chance mutation in the attenuated virus had produced a highly efficacious strain that was named 17D. After field trials in Brazil, over one million people were vaccinated by 1939, without severe complications. For his work on the yellow fever vaccine, Theiler received the 1951 Nobel Prize in Physiology or Medicine. Only the 17D vaccine remains in use today. The outbreak of yellow fever in Angola in January 2016 has raised concerns about whether the global supply of vaccine is adequate to meet the need during a large
Theiler's disease multiple horses over several months. In the Northern hemisphere it is most common between August to November. It is seen almost exclusively in adult horses, and lactating broodmares given tetanus antitoxin post foaling may be more susceptible. This disease was described in 1919 by Arnold Theiler, a South African veterinary surgeon, after vaccinating horses against African horse sickness using a live virus vaccine and equine antiserum. It was later described in the United States after vaccinating horses for Eastern Equine Encephalitis, again using live virus vaccines and equine-derived antiserum. It has since been reported throughout North America and Europe. Theiler's