Culture of South Africa originated in South Africa. The first human-to-human heart transplant was performed by cardiac surgeon Christiaan Barnard at Groote Schuur Hospital in December 1967. Max Theiler developed a vaccine against Yellow Fever, Allan McLeod Cormack pioneered x-ray Computed tomography, and Aaron Klug developed crystallographic electron microscopy techniques. These advancements were all (with the exception of that of Barnard) recognised with Nobel Prizes. Sydney Brenner won most recently, in 2002, for his pioneering work in molecular biology. Mark Shuttleworth founded an early Internet security company Thawte, that was subsequently bought out by world-leader VeriSign. South Africa has cultivated a burgeoning astronomy community.
Nobel Prize controversies possibility is that Nobel did not consider mathematics as a practical discipline. Both the Fields Medal and the Abel Prize have been described as the "Nobel Prize of mathematics". The most notorious controversies have been over prizes for Literature, Peace and Economics. Beyond disputes over which contributor's work was more worthy, critics most often discerned political bias and Eurocentrism in the result. The interpretation of Nobel's original words concerning the Literature prize has also undergone repeated revisions. The 2008 prize was awarded to Osamu Shimomura, Martin Chalfie and Roger Y. Tsien for their work on green fluorescent protein or GFP.