Oswaldo Cruz father-in-law, a wealthy Portuguese merchant. Cruz found the seaport of Santos ravaged by an epidemic of bubonic plague that threatened to reach Rio de Janeiro and engaged himself immediately in the combat of this disease. The mayor of Rio de Janeiro authorized the construction of a plant for manufacturing the serum against the disease which had been developed at the Pasteur Institute by Alexandre Yersin and coworkers. He asked the institution for a scientist who could bring to Brazil this know-how. The Pasteur Institute responded that such a person was already available in Brazil: Dr. Oswaldo Cruz. On May 25,
South American Institute of Government in Health one example. In November 2009, through Resolution 05/2009, the South American Council of Health decided to create ISAGS. Rio de Janeiro would have its Headquarters. The Human Resources Technical Group was in charge of elaborating of the institute's project.<ref name="UNASUR South American Health Council's Resolution 05/2009"> UNASUR South American Council of Health's Resolution 05/2009</ref> According to Paulo Buss, who envioned the institute, it was created to "be the a space for permanent analysis of the impact of health policies, including the efficiency of implemented attention models (...) it establish a dialog with other experiences accumulated by other regional centres (like