Brazil tourists in 2005. In 2005, Rio de Janeiro, Foz do Iguaçu, São Paulo, Florianópolis and Salvador were the most visited cities by international tourists for leisure trips. The most popular destinations for business trips were São Paulo, Rio de Janeiro and Porto Alegre. In 2006 Rio de Janeiro and Fortaleza were the most popular destinations for business trips. Technological research in Brazil is largely carried out in public universities and research institutes, with the majority of funding for basic research coming from various government agencies. Brazil's most esteemed technological hubs are the Oswaldo Cruz Institute, the Butantan Institute, the Air
Oswaldo Cruz 1900, the Federal Serum Therapy Institute destined to the production of sera and vaccines against the bubonic plague was created with Baron Pedro Afonso as director general and the young bacteriologist Oswaldo Cruz as technical director. The new institute was established in the old farm of Manguinhos at the western shores of Guanabara Bay. In 1902, Cruz accepted the office of director general of the institute and soon expanded the scope of its activities, now no longer restricted to the production of sera but also dedicated to basic and applied research and to the building of human resources. In the