Theiler's encephalomyelitis virus Theiler's encephalomyelitis virus Theiler's Murine Encephalomyelitis Virus (TMEV) is a single-stranded RNA murine cardiovirus from the family "Picornaviridae". It has been used as a mouse model for studying virally induced paralysis, as well as encephalomyelitis comparable to Multiple sclerosis. Depending on the mouse and viral strain, viral pathogenesis can range from negligible, to chronic or acute encephalomyelitis. The virus was discovered by virologist Max Theiler in 1937 while working at the Rockefeller Institute. Theiler discovered the encephalomyelitis virus during research on poliovirus-like paralysis symptoms in mice. That year Theiler had completed work on developing a vaccine for Yellow Fever, for
Nobel Prize controversies Erwin Hahn for his contribution to the principles of spin echoes. The 2000 prize went to Arvid Carlsson, Paul Greengard, and Eric R. Kandel, "for their discoveries concerning signal transduction in the nervous system". The award caused many neuroscientists to protest that Oleh Hornykiewicz, who helped pioneer the dopamine replacement treatment for Parkinson's disease, was left out, and that Hornykiewicz's research provided a foundation for the honorees' success. The Nobel Prize for Physiology or Medicine was awarded in 1998 to Robert Furchgott, Louis Ignarro and Ferid Murad "for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular