Agassi–Sampras rivalry the 1990 US Open, with Agassi the favorite because of his top-three ranking even though Sampras had defeated former World No. 1 players Ivan Lendl and John McEnroe on the way to the final. Sampras defeated Agassi in straight sets. The next time the pair met at a Grand Slam final was at the 1995 Australian Open. Agassi beat Sampras in four sets. In one of their matches, played in the 2001 US Open quarter-final, Sampras won with the score of 6–7(7), 7–6(2), 7–6(2), 7–6(5); throughout the match, no player managed to break the other's serve. The last match in
Andre Agassi the Countrywide Classic in Los Angeles to Fernando González of Chile, which resulted in him being unseeded at the US Open. Agassi had a short, but dramatic, run in his final US Open. Because of extreme back pain, Agassi was forced to receive anti-inflammatory injections after every match. After a tough four-set win against Andrei Pavel, Agassi faced eighth-seeded Marcos Baghdatis in the second round who had earlier advanced to the 2006 Australian Open final and Wimbledon semifinals. Agassi won in five tough sets as the younger Baghdatis succumbed to muscle cramping in the final set. In his last match,