Brazil tourists in 2005. In 2005, Rio de Janeiro, Foz do Iguaçu, São Paulo, Florianópolis and Salvador were the most visited cities by international tourists for leisure trips. The most popular destinations for business trips were São Paulo, Rio de Janeiro and Porto Alegre. In 2006 Rio de Janeiro and Fortaleza were the most popular destinations for business trips. Technological research in Brazil is largely carried out in public universities and research institutes, with the majority of funding for basic research coming from various government agencies. Brazil's most esteemed technological hubs are the Oswaldo Cruz Institute, the Butantan Institute, the Air
Oswaldo Cruz existed since 1837 but had never been put into practice. Therefore, on June 9, 1904, following a proposal by Oswaldo Cruz, the government presented a bill to the Congress requesting the reestablishment of obligatory smallpox vaccination. The extremely rigid and severe provisions of this instrument terrified the people. Popular opposition against Cruz increased sharply and opposition newspapers started a violent campaign against this and the federal government in general. Members of the parliament and labor unions protested. An anti-vaccination league was organized. On November 10, the Vaccine Revolt exploded in Rio. Violent confrontations with the police ensued, with strikes, barricades,