Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Medical certifications for pilots in detail in CFR 61.303. Depending upon which Class certificate a pilot wants or needs, it is possible that either the Aviation Medical Examiner or the FAA may deny a pilot's medical certificate. This may be due to recent surgery, medication taken, non-aviation-related offenses (such as drunk driving citations), or any other medical condition. Pilots may appeal denials up to and including formal appeals to the National Transportation Safety Board. The process of making an appeal includes meticulous documentation of a pilot's medical condition, therapies involved in treatment, and may be accompanied by psychological evaluations and/or other data. While any