Southern Illinois the Ozarks of Missouri, is chiefly in southern Jackson, Union, northern Alexander and Johnson counties. The eastern area, more closely related to the Wabash Valley Seismic Zone, is mostly in northern Pope, southern Saline, Gallatin, eastern Johnson and southern Williamson counties. The Shawnee National Forest covers a large territory, including seven wilderness areas: Garden of the Gods, Bay Creek, Clear Springs, Bald Knob, Burden Falls, Lusk Creek, and Panthers Den. Of southern Illinois' rivers, only the Mississippi and the Ohio are navigable for modern commerce. The Big Muddy River, Marys River, Saline River and Cache River run their courses in
Muddy River (Nevada) to the Colorado River and followed it westward. In 1844, the expedition of John C. Frémont discovered a cutoff route that avoided the Colorado River, following a route between Resting Springs in California, and the Virgin River Valley that passed through Las Vegas Springs and crossed the Muddy River near modern Glendale. Mormon pioneers blazed a wagon road from Salt Lake City to Los Angeles along this pack trail in 1847, followed by Forty-niners attempting avoid the winter snows of the Sierra Nevada Mountains, and wagon trains of Mormon colonists on their way to settle in San Bernardino in 1852.