Ovine pulmonary adenocarcinoma as an animal model for human lung cancer, because OPA is histologically similar to human adenocarcinoma in situ of the lung. Dolly the sheep, the first mammal successfully cloned from an adult somatic cell, was euthanized after it was confirmed that she had OPA. Ovine pulmonary adenocarcinoma Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. OPA is caused by a retrovirus called jaagsiekte sheep retrovirus (JSRV). The disease has a long incubation period, and therefore signs usually occur in adult animals (over 2
Ovine rinderpest detected in acute cases from various swabs and blood samples, using PCR and ELISA. Antibodies can also be detected by ELISA. Antibiotics such as chloramphenicol, penicillin, and streptomycin can be used and supportive treatment may be helpful. Additionally, a vaccine has been developed that may decrease death in the flock. Movement restrictions and slaughter of affected flocks may be required in an attempt to eradicate the disease. A global eradication programme has been developed by the Food and Agriculture Organization of the United Nations and the World Organisation for Animal Health. More information can be found on FAO's website on