Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Heat treating cylindrical retort made from high temperature alloy, filled with sand-like aluminium oxide particulate. Gas (air or nitrogen) is bubbled through the oxide and the sand moves in such a way that is exhibits fluid-like behaviour, hence the term "fluidised". The solid-solid contact of the oxide gives very high thermal conductivity and excellent temperature uniformity throughout the furnace, comparable to those seen in a salt bath. Heat treating Heat treating (or heat treatment) is a group of industrial and metalworking processes used to alter the physical, and sometimes chemical, properties of a material. The most common application is metallurgical. Heat treatments