Propolis propolis has approximately 50 constituents, primarily resins and vegetable balsams (50%), waxes (30%), essential oils (10%), and pollen (5%). Propolis also contains persistent lipophilic acaricides, a natural pesticide that deters mite infestations. In neotropical regions, in addition to a large variety of trees, bees may also gather resin from flowers in the genera "Clusia" and "Dalechampia", which are the only known plant genera that produce floral resins to attract pollinators. "Clusia" resin contains polyprenylated benzophenones. In some areas of Chile and Argentina Andean valleys, propolis contains viscidone, a terpene from "Baccharis" shrubs, and in Brazil and Paraguay, naphthoquinone epoxide has
Substance dependence upon which a person has developed a dependence syndrome. When dependence has developed, cessation of substance use produces an unpleasant state, which promotes continued drug use through negative reinforcement; i.e., the drug is used to escape or avoid re-entering the associated withdrawal state. The withdrawal state may include physical-somatic symptoms (physical dependence), emotional-motivational symptoms (psychological dependence), or both. Chemical and hormonal imbalances may arise if the substance is not introduced. Psychological stress may also result if the substance is not re-introduced. Infants also suffer from substance withdrawal, known as Neonnatal Abstinence Syndrome (NAS) which has severe and life-threatening effects on