Ovine pulmonary adenocarcinoma be predisposed to OPA. Most affected sheep show signs at 2 to 4 years of age. OPA is not a notifiable disease, and therefore it is difficult to assess its prevalence. OPA was first described in the UK in 1888, and described in detail in South Africa in 1891. The disease was initially known as "jaagsiekte" , a word derived from Afrikaans, meaning "chasing sickness," so called because animals are in respiratory distress as if they are out of breath from being chased. It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. OPA has been used
Pack animal Pack animal A pack animal or beast of burden is an individual or type of working animal used by humans as means of transporting materials by attaching them so their weight bears on the animal's back, in contrast to draft animals which pull loads but do not carry them. Traditional pack animals are diverse including camels, goats, yaks, reindeer, water buffaloes, and llamas as well as the more familiar pack animals like horses, donkeys and mules. The term "pack animal" is traditionally used in contrast to "draft animal", which is a working animal that typically pulls a load behind itself