Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Muddy River (Washington) rapidly, passing under Forest Road 25 and then receiving Clear Creek from the left about from the mouth. At the road crossing, Muddy Creek Picnic Site is on the left. Below the confluence with Clear Creek, the river meanders through Cedar Flats, leaves the national forest slightly more than a mile from the mouth, and passes a United States Geological Survey (USGS) stream gauge, on the left from the mouth. Muddy River enters the Lewis River about from the larger stream's mouth on the Columbia River. The USGS monitors the flow of Muddy River at a station upstream of the