Mesopotamia Mesopotamia Mesopotamia is a historical region in Western Asia situated within the Tigris–Euphrates river system, in modern days roughly corresponding to most of Iraq, Kuwait, parts of Northern Saudi Arabia, the eastern parts of Syria, Southeastern Turkey, and regions along the Turkish–Syrian and Iran–Iraq borders. The Sumerians and Akkadians (including Assyrians and Babylonians) dominated Mesopotamia from the beginning of written history (c. 3100 BC) to the fall of Babylon in 539 BC, when it was conquered by the Achaemenid Empire. It fell to Alexander the Great in 332 BC, and after his death, it became part of the Greek Seleucid
History of Mesopotamia often dubbed the cradle of civilization. The rise of the first cities in southern Mesopotamia dates to the Uruk period, from c. 4000 BC onward; its regional independence ended with the Achaemenid conquest in 539 BC, although a few native neo-Assyrian kingdoms existed at different times. Mesopotamia literally means "(Land) between rivers" in ancient Greek. The oldest known occurrence of the name Mesopotamia dates to the 4th century BC, when it was used to designate the land east of the Euphrates in north Syria. Later it was more generally applied to all the lands between the Euphrates and the Tigris,