Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Fox River (Illinois River tributary) area. From the chain, the river flows generally southward for , until it joins the Illinois River at Ottawa. Illinois towns and communities that are on the Fox River include (from north to south): Fox Lake, Johnsburg, McHenry, Holiday Hills, Island Lake, Burtons Bridge, Port Barrington, Cary, Fox River Grove, Algonquin, Carpentersville, West Dundee, East Dundee, Elgin, South Elgin, St. Charles, Geneva, Batavia, North Aurora, Aurora, Montgomery, Oswego, Yorkville, Plano, Millington, Sheridan and Ottawa. Collectively, the area surrounding the Fox River is known as the Fox Valley. Around 1 million people live in this area. Native American tribes that lived