Testicle fetal abdomen to the inguinal ring and beyond to the inguinal canal and into the scrotum. In most cases (97% full-term, 70% preterm), both testes have descended by birth. In most other cases, only one testis fails to descend (cryptorchidism) and that will probably express itself within a year. The testes grow in response to the start of spermatogenesis. Size depends on lytic function, sperm production (amount of spermatogenesis present in testis), interstitial fluid, and Sertoli cell fluid production. After puberty, the volume of the testes can be increased by over 500% as compared to the pre-pubertal size. Testicles are
Users' Guides to the Medical Literature Guyatt introduced the term "evidence-based medicine" to stress the role of rigorous, systematic evidence from clinical research in conjunction with patients’ values and preferences in clinical decision-making. A group of academic physicians subsequently formed the international Evidence-based Medicine Working Group and published a 1992 article announcing the "new paradigm" of evidence-based medicine. The Evidence-based Medicine Working Group decided to build on the popular series in the "Canadian Medical Association Journal" by creating a more practical approach to applying the medical literature to clinical practice. Championed by Dr. Drummond Rennie, an editor of the "Journal of the American Medical Association", the