Mesopotamia Mesopotamia Mesopotamia is a historical region in Western Asia situated within the Tigris–Euphrates river system, in modern days roughly corresponding to most of Iraq, Kuwait, parts of Northern Saudi Arabia, the eastern parts of Syria, Southeastern Turkey, and regions along the Turkish–Syrian and Iran–Iraq borders. The Sumerians and Akkadians (including Assyrians and Babylonians) dominated Mesopotamia from the beginning of written history (c. 3100 BC) to the fall of Babylon in 539 BC, when it was conquered by the Achaemenid Empire. It fell to Alexander the Great in 332 BC, and after his death, it became part of the Greek Seleucid
Mesopotamia (Roman province) Mesopotamia (Roman province) Mesopotamia was the name of two distinct Roman provinces, the one a short-lived creation of the Roman Emperor Trajan in 116–117 and the other established by Emperor Septimius Severus in ca. 198, which ranged between the Roman and the Sassanid empires, until the Muslim conquests of the 7th century. In 113, Emperor Trajan (r. 98–117) launched a war against Rome's long-time eastern rival, the Parthian Empire. In 114, he conquered Armenia, which was made into a province, and by the end of 115, he had conquered northern Mesopotamia. This too was organized as a province in early