Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Muddy River (Washington) 83 and passes the Ape Canyon Trailhead and the Lava Canyon Interpretive Site, both on the left, before entering Muddy River Gorge. Flowing northeast through the gorge, the stream plunges over three waterfalls before emerging from the narrows and curving sharply again to the southeast. Here Crane Lake is on the left, Smith Creek enters from the left, and Smith Creek Trailhead is on the right. Slightly downstream of the trailhead, the river leaves the national volcanic monument but remains in the national forest. At about the level, Clearwater Creek enters from the left. Turning south, the river descends less