Decriminalization of non-medical cannabis in the United States drug, which contains a very active component delta-9-tetrahydrocannabinol (THC). For thousands of years, it was used for medical purposes in many different parts of the world. Recent studies also agreed that THC had great potential benefits for medical purposes. A number of patients who have HIV, multiple sclerosis (MS), neuropathic chronic pain, and cancer were under medical marijuana treatment. The treatments could either be smoke on cannabis or oral preparations, which were synthetic THC and synthetic equivalent. According to Medical Uses of Marijuana (Cannabis sativa), patients with HIV reported that the drug reduced mixed neuropathic pain more significantly in comparison
Medical cannabis medicines are available in pill form (dronabinol and nabilone) and liquid extracts formulated into an oromucosal spray (nabiximols). Oral preparations are "problematic due to the uptake of cannabinoids into fatty tissue, from which they are released slowly, and the significant first-pass liver metabolism, which breaks down Δ9THC and contributes further to the variability of plasma concentrations". The US Food and Drug Administration (FDA) has not approved smoked cannabis for any condition or disease, as it deems that evidence is lacking concerning safety and efficacy. The FDA issued a 2006 advisory against "smoked" medical cannabis stating: "marijuana has a high potential