Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Novikov's condition Novikov's condition In probability theory, Novikov's condition is the sufficient condition for a stochastic process which takes the form of the Radon–Nikodym derivative in Girsanov's theorem to be a martingale. If satisfied together with other conditions, Girsanov's theorem may be applied to a Brownian motion stochastic process to change from the original measure to the new measure defined by the Radon–Nikodym derivative. This condition was suggested and proved by Alexander Novikov. There are other results which may be used to show that the Radon–Nikodym derivative is a martingale, such as the more general criterion Kazamaki's condition, however Novikov's condition is