Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Vermilion River (Illinois River) Vermilion River (Illinois River) The Vermilion River is a tributary of the Illinois River in the state of Illinois, United States. The river flows north, in contrast to a second Vermilion River in Illinois, which flows south to the Wabash River. The Illinois and Wabash rivers each have a tributary named the Little Vermilion River as well. The north-flowing Vermilion River and the south-flowing Middle Fork Vermilion River run on what is close to a straight line between Oglesby and Danville. In presettlement times, the two rivers drained an upland marsh near Roberts. It is possible that early settlers regarded