Dr. No (film) stylised main title sequence, both of which were created by Maurice Binder. It also established the iconic "James Bond" theme music. Production designer Ken Adam established an elaborate visual style that is one of the hallmarks of the film series. John Strangways, the British MI6 Station Chief in Jamaica, and his secretary are ambushed and killed. The assassins steal documents related to "Crab Key" and "Doctor No". In response, M, the head of MI6, instructs agent James Bond to investigate Strangways' disappearance and to determine whether it is related to his co-operation with the American Central Intelligence Agency (CIA) on
Dr. No (film) just over $5 billion in box office returns alone, making the series one of the highest-grossing ever. It is estimated that since "Dr. No", a quarter of the world's population have seen at least one "Bond" film. "Dr. No" also launched a successful genre of "secret agent" films that flourished in the 1960s. The UK Film Distributors' Association have stated that the importance of "Dr. No" to the British film industry cannot be overstated, as it, and the subsequent "Bond" series of films, "form the backbone of the industry". "Dr. No" – and the "Bond" films in general – also