Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Club drug UN conventions unless used in a medical or religious context. Despite these regulations, recreational use of psychedelics is common, including at raves and EDM concerts and festivals. "Poppers" are small bottles of volatile drugs which are inhaled by clubgoers for the "rush" or "high" that they can create. Nitrites such as alkyl nitrite originally came as small glass capsules that were popped open, which led to the nickname "poppers." The drug became popular in the US first on the disco/club scene of the 1970s, where dancers used the drug for the "rush" it provides, and because it was perceived to