Ovine pulmonary adenocarcinoma be predisposed to OPA. Most affected sheep show signs at 2 to 4 years of age. OPA is not a notifiable disease, and therefore it is difficult to assess its prevalence. OPA was first described in the UK in 1888, and described in detail in South Africa in 1891. The disease was initially known as "jaagsiekte" , a word derived from Afrikaans, meaning "chasing sickness," so called because animals are in respiratory distress as if they are out of breath from being chased. It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. OPA has been used
Fixed Cut-Off Date Animal Testing Policy Fixed Cut-Off Date Animal Testing Policy In the European Union, the Fixed Cut-Off Date (FCOD) Animal Testing Policy relates to the testing of ingredients used in the manufacture of cosmetics, toiletries and household products. A company’s FCOD is a date after which none of the ingredients in its products has been tested on animals. The policy is recognised by animal welfare groups worldwide as the benchmark for cruelty free cosmetics / toiletries and household cleaning products because companies with a FCOD policy will not use any ingredient tested on animals after a specific date. The FCOD Animal Testing Policy is