Interbreeding between archaic and modern humans been shown that Neanderthal ancestry has been selected against in conserved biological pathways, such as RNA processing. Consistent with the hypothesis that purifying selection has reduced Neanderthal contribution in present-day modern human genomes, Upper Paleolithic Eurasian modern humans (such as the Tianyuan modern human) carry more Neanderthal DNA (about 4–5%) than present-day Eurasians modern humans (about 1–2%). Genes affecting keratin were found to have been introgressed from Neanderthals into modern humans (shown in East Asians and Europeans), suggesting that these genes gave a morphological adaptation in skin and hair to modern humans to cope with non-African environments. This is likewise
In the Skin of a Lion "It is a novel about the wearing and the removal of masks; the shedding of skin, the transformations and translations of identity." An important aspect of the novel is its depiction of Toronto in the 1930s. Ondaatje spent many months in the archives of the City of Toronto and newspapers of the era. Prominence is given to the construction of two Toronto landmarks, the Prince Edward Viaduct, commonly known as the Bloor Street Viaduct, and the R. C. Harris Water Treatment Plant, and focuses on the lives of the immigrant workers. The plot incorporates a number of true stories of