Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Rockefeller Drug Laws of the most conservative public figures in America, was staunchly against it, as well as many in law enforcement, who saw inherent unfairness in placing the non-violent crime of drug trafficking on a par with murder. Economist Murray Rothbard called the laws "draconian: long jail sentences for heroin pushers and addicts. The Rockefeller program, which proved finally to be a fiasco, was the epitome of the belief in treating a social or medical problem with jail and the billy club." The laws also drew intense opposition from civil rights advocates, who claimed that they were racist, as they were applied