Honey extraction abrading the surface of the wax with moving chains or bristles or hot knives. This, while messy, makes the process easier than doing this task manually. Some beekeepers will also harvest (before uncapping the honey) the propolis, a resinous material bees gather to glue the frames together; propolis is used for its medicinal properties. Once uncapped, the frames are then placed in a honey extractor, which spins them so that most of the honey is removed by centrifugal force. Care must be taken to ensure that all frames are loaded correctly, as the comb is angled slightly upwards to prevent
Substance dependence Substance dependence Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use. A "drug addiction", a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An "addictive drug" is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral addiction and drug addictions, but not dependence. Within the framework of the 4th edition of