Ovine pulmonary adenocarcinoma be predisposed to OPA. Most affected sheep show signs at 2 to 4 years of age. OPA is not a notifiable disease, and therefore it is difficult to assess its prevalence. OPA was first described in the UK in 1888, and described in detail in South Africa in 1891. The disease was initially known as "jaagsiekte" , a word derived from Afrikaans, meaning "chasing sickness," so called because animals are in respiratory distress as if they are out of breath from being chased. It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. OPA has been used
Animal cafe style at the cafe. Some visitors of animal cafe in Japan express their concerns for the safety and welfare of the birds. They argue that there is a natural daily routine for birds but this animal cafe does not care about it. Japanese animal rights activists also argue that bird cafes abuse birds as the entertainment of humans and birds meant to fly in the sky rather than staying in the building.As a result, Japanese government had made much stricter Animal Protection Law which strengths the new rules and restricts trading hours of animal cafe in order to release controversies.