Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Illinois River was relocated to the present site of Creve Coeur, near Peoria, where the Jesuits relocated. The Peoria Riverfront Museum contains a gallery, "Illinois River Encounter," that attempts to interpret the museum through an aquarium tank and displays of the river's geology, ecology, social history, engineering, and commercial use. From 1905 to 1915, more freshwater fish were harvested from the Illinois River than from any other river in the United States except for the Columbia River. The Illinois River was once a major source of mussels for the shell button industry. Overfishing, habitat loss from heavy siltation, and water pollution have