Honey extraction abrading the surface of the wax with moving chains or bristles or hot knives. This, while messy, makes the process easier than doing this task manually. Some beekeepers will also harvest (before uncapping the honey) the propolis, a resinous material bees gather to glue the frames together; propolis is used for its medicinal properties. Once uncapped, the frames are then placed in a honey extractor, which spins them so that most of the honey is removed by centrifugal force. Care must be taken to ensure that all frames are loaded correctly, as the comb is angled slightly upwards to prevent
Substance dependence upon which a person has developed a dependence syndrome. When dependence has developed, cessation of substance use produces an unpleasant state, which promotes continued drug use through negative reinforcement; i.e., the drug is used to escape or avoid re-entering the associated withdrawal state. The withdrawal state may include physical-somatic symptoms (physical dependence), emotional-motivational symptoms (psychological dependence), or both. Chemical and hormonal imbalances may arise if the substance is not introduced. Psychological stress may also result if the substance is not re-introduced. Infants also suffer from substance withdrawal, known as Neonnatal Abstinence Syndrome (NAS) which has severe and life-threatening effects on