Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Muddy River (Washington) Muddy River Picnic Site, next to the river and to Forest Road 25 in the Gifford Pinchot National Forest. Trails cross the river on its upper reaches. Muddy River originates at about the level on the southeast side of Mount St. Helens in the Cascade Range. The river source is within Mount St. Helens National Volcanic Monument and Gifford Pinchot National Forest. Shoestring Glacier is to the right and East Dome is to the left. Flowing southeast down steep slopes, the river curves sharply to the northeast just beyond the level of the volcano. Here the river crosses Forest Road