Formula unit Formula unit A formula unit in chemistry is the empirical formula of any ionic or covalent network solid compound used as an independent entity for stoichiometric calculations. It is the lowest whole number ratio of ions represented in an ionic compound. Examples include ionic NaCl and KO and covalent networks such as SiO and C (as diamond or graphite). Ionic compounds do not exist as individual molecules; a formula unit thus indicates the lowest reduced ratio of ions in the compound. A "chemical formula" shows the kinds and numbers of atoms in the smallest representative unit of a substance. In
Substance dependence Substance dependence Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use. A "drug addiction", a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An "addictive drug" is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral addiction and drug addictions, but not dependence. Within the framework of the 4th edition of