Propolis propolis has approximately 50 constituents, primarily resins and vegetable balsams (50%), waxes (30%), essential oils (10%), and pollen (5%). Propolis also contains persistent lipophilic acaricides, a natural pesticide that deters mite infestations. In neotropical regions, in addition to a large variety of trees, bees may also gather resin from flowers in the genera "Clusia" and "Dalechampia", which are the only known plant genera that produce floral resins to attract pollinators. "Clusia" resin contains polyprenylated benzophenones. In some areas of Chile and Argentina Andean valleys, propolis contains viscidone, a terpene from "Baccharis" shrubs, and in Brazil and Paraguay, naphthoquinone epoxide has
Substance-related disorder recently published DSM-5 combined substance abuse and substance dependence into a single continuum; this is simply known as substance use disorder and requires more presenting symptoms before a diagnosis is made. It also considers each different substance as its own separate disorder, based upon the same basic criteria. It also distinguishes the difference between dependence and addictions as two separate disorders, not to be confused. There are many potential complications that can arise due to substance abuse such as severe physiological damage, psychological changes and social changes that are often not desirable. Physiological damage is often the most obvious, observed