Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Legal drug trade Legal drug trade Legal drug trade, as with other goods object of commerce, in opposition to smuggling or "illegal" drug trade, most psychotropic substances' commerce is under control and taxation by world governments, regardless of the relative perceived danger of the goods that are the object of legislation. Legal commerce in drugs can be categorized according to the purpose of consumption (therapeutic vs recreational), type of drug involved and phase of the trading process, i.e.: production, distribution or consumption. Drugs useful for treating diseases are the object of pharmaceutical research and medical practice, and produced by the pharmaceutical industry, which