Ohio River course forms the northern borders of West Virginia and Kentucky; and the southern borders of Ohio, Indiana and Illinois, until it joins the Mississippi River at the city of Cairo, Illinois. Where the Ohio joins the Mississippi is the lowest elevation in the state of Illinois, at . The Ohio River, which flows westward from Pittsburgh, Pennsylvania, to Cairo, Illinois, is the largest tributary, by volume, of the Mississippi River in the United States. At the confluence, the Ohio is considerably bigger than the Mississippi. Measured by long-term mean discharge in cubic feet per second and cubic meters per second,
Muddy River (Nevada) the Meadow Valley Wash, forming the principal drainage system for southeastern Nevada. The Moapa Valley area is home to a wide variety of rare and endangered species, including fish, invertebrates, birds, and plants. Three endangered fish inhabit the area: the Moapa dace ("Moapa coriacea"), the Virgin River chub ("Gila seminuda"), and the White River springfish ("Crenichthys baileyi moapae"). These species can be found throughout the various springs, called the Muddy Springs, that feed the Muddy River. The U.S. Fish and Wildlife Service has created the Moapa National Wildlife Refuge at the Warm Springs Natural Area, as part of the Desert