Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Southern Illinois River-to-River Conference approached by Benton, Herrin, Harrisburg, and West Frankfort for membership; these four schools were concerned over their small size relative to the other members of the South Seven Conference (where all four were then located) and sought out a conference more in line with their size. Massac County (then an independent school) was approached about becoming a member, and in 1993 the Southern Illinois River-to-River Conference was formed. At the start of the 2010-2011 school year Carterville left the Black Diamond Conference to join the Southern Illinois River-to-River Conference. Chester High School has taken their place in the Black Diamond