Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Big Annemessex River Annemessex River; the city of Crisfield rests upon its shores. Big Annemessex River The Big Annemessex River is a tributary of the Chesapeake Bay on the Delmarva Peninsula. It rises in Kingston, Somerset County, Maryland, and flows roughly southwest about in a meandering pattern, then widens into an estuary and continues about to the bay, near Janes Island State Park. Tributaries include Annemessex Creek, Holland Creek, Hall Creek, Muddy Creek, Colbourn Creek, Jones Creek and Daugherty Creek. The river is spanned once by River Road, a residential county road far from any population center. The Annemessex Creek upstream, however, is