Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Knaster's condition Knaster's condition In mathematics, a partially ordered set "P" is said to have Knaster's condition upwards (sometimes property (K)) if any uncountable subset "A" of "P" has an upwards-linked uncountable subset. An analogous definition applies to Knaster's condition downwards. The property is named after Polish mathematician Bronisław Knaster. Knaster's condition implies the countable chain condition (ccc), and it is sometimes used in conjunction with a weaker form of Martin's axiom, where the ccc requirement is replaced with Knaster's condition. Not unlike ccc, Knaster's condition is also sometimes used as a property of a topological space, in which case it means