Big Muddy National Fish and Wildlife Refuge Big Muddy National Fish and Wildlife Refuge The Big Muddy National Fish and Wildlife Refuge was established in 1994, and has grown to over . Like pearls on a string, these acres are spread out as individual units along the Missouri River between Kansas City and St. Louis. These pearls of habitat benefit floodplain-dependent fish and wildlife species. The Big Muddy Refuge is planning to grow to by buying land from willing sellers who want to see their properties set aside for the benefit of wildlife and the enjoyment of all. The pre-development Missouri River as documented by Lewis and
Muddy River (Nevada) to the Colorado River and followed it westward. In 1844, the expedition of John C. Frémont discovered a cutoff route that avoided the Colorado River, following a route between Resting Springs in California, and the Virgin River Valley that passed through Las Vegas Springs and crossed the Muddy River near modern Glendale. Mormon pioneers blazed a wagon road from Salt Lake City to Los Angeles along this pack trail in 1847, followed by Forty-niners attempting avoid the winter snows of the Sierra Nevada Mountains, and wagon trains of Mormon colonists on their way to settle in San Bernardino in 1852.