Southern Illinois took place in Williamson County between 1839 and 1876. This was unusual, as crime was almost non-existent in Illinois during its frontier years prior to this period of lawlessness. In 1858, Abraham Lincoln ran for the U.S. Senate against Stephen A. Douglas. A debate was held in seven towns in Illinois, one being near Jonesboro. Many of the people living in Southern Illinois were first- or second-generation Southerners. Cairo, Illinois, at the southern tip where the Ohio River joins the Mississippi, was of strategic importance. On either side of the rivers were states which, despite remaining in the Union, had
Muddy River (Nevada) to the Colorado River and followed it westward. In 1844, the expedition of John C. Frémont discovered a cutoff route that avoided the Colorado River, following a route between Resting Springs in California, and the Virgin River Valley that passed through Las Vegas Springs and crossed the Muddy River near modern Glendale. Mormon pioneers blazed a wagon road from Salt Lake City to Los Angeles along this pack trail in 1847, followed by Forty-niners attempting avoid the winter snows of the Sierra Nevada Mountains, and wagon trains of Mormon colonists on their way to settle in San Bernardino in 1852.