Ovine rinderpest virus does not infect humans. This disease was first described in 1942 in Côte d'Ivoire. Now, PPR has spread to more than 70 countries in the world. In 2017, the disease was reported to be affecting saiga in Mongolia, causing near-catastrophic herd depletion for the endangered species. In 2018, the disease was reported to be in Bulgaria close to the border with Turkey. PPR is also known as goat plague, "kata", syndrome of stomatitis-pneumoenteritis, and ovine rinderpest. Official agencies such as the FAO and OIE use the French name ""peste des petits ruminants"" with several spelling variants. Symptoms are similar
Alternatives to animal testing performed on intact animals, the maintenance of cells in culture normally requires the use of animal-derived serum. Although exact figures are difficult to obtain, some have estimated that one million fetal cows are sacrificed each year to obtain the world's supply of fetal bovine serum, used to grow cultured cells. Skin irritation and skin corrosion refer to localized toxic effects resulting from a topical exposure of the skin to a substance. Human skin equivalent tests can be used to replace animal-based corrosive and irritative studies. EpiDerm from Mattek and EpiSkin and SkinEthic RHE model are derived from human skin cells