Toronto (cocktail) Embury, and in 1949 a recipe for the Toronto Cocktail was included in "Esquire's Handbook for Hosts". The Toronto Cocktail is a variation of the Old Fashioned, with the addition of Fernet-Branca. Variations of the cocktail substitute various rye whiskeys as the primary ingredient, such as Canadian whisky or Old Overholt. The Fernet Cocktail recipe by Vermeire specified of cognac or rye whisky, and gill of Fernet-Branca. The rye whisky complements the bitter Fernet-Branca and prevents it from dominating the cocktail. Sugar or simple syrup are used to reduce the cocktail's bitterness. It may be served in a cocktail glass
Cooperstown cocktail Cooperstown cocktail The Cooperstown cocktail refers to a panel of four drug probes used in human pharmacokinetic studies to determine the activity of drug metabolising enzymes. The terminology 'cocktail' refers to the fact that the drug probes are given together. The Cooperstown cocktail consists of four drugs that are considered specific substrates for four cytochrome P450 (CYP) isoforms. One of the drugs (caffeine) provides, through its metabolites, substrates for two additional enzymes (see next paragraph). The drugs and the enzymes they probe are as follows - caffeine (probes CYP1A2, N-acetyltransferase 2, xanthine oxidase), midazolam (probes CYP3A), omeprazole (probes CYP2C19) and