Ovine rinderpest Ovine rinderpest Ovine rinderpest, also commonly known as peste des petits ruminants (PPR), is a contagious disease primarily affecting goats and sheep; however, camels and wild small ruminants can also be affected. PPR is currently present in North, Central, West and East Africa, the Middle East, and South Asia. It is caused by "small ruminants morbillivirus" in the genus "Morbillivirus," and is closely related to, among others," rinderpest morbillivirus, measles morbillivirus", and "canine morbillivirus" (previously known as canine distemper virus). The disease is highly contagious, and can have a 80–100% mortality rate in acute cases in an epidemic setting. This
Alternatives to animal testing performed on intact animals, the maintenance of cells in culture normally requires the use of animal-derived serum. Although exact figures are difficult to obtain, some have estimated that one million fetal cows are sacrificed each year to obtain the world's supply of fetal bovine serum, used to grow cultured cells. Skin irritation and skin corrosion refer to localized toxic effects resulting from a topical exposure of the skin to a substance. Human skin equivalent tests can be used to replace animal-based corrosive and irritative studies. EpiDerm from Mattek and EpiSkin and SkinEthic RHE model are derived from human skin cells