Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Big Thompson River tributary flows east, through the town of Glen Haven, where it merges with the Big Thompson River in the town of Drake, in the Big Thompson Canyon. From Lake Estes, the river descends 1/2 mile (800 m) in elevation through the mountains in the spectacular 25 mi (40 km) Big Thompson Canyon, emerging from the foothills west of Loveland. It flows eastward, south of Loveland across the plains into Weld County and joins the South Platte approximately 5 mi (8 km) south of Greeley. It receives the Little Thompson River approximately four mi (6 km) upstream from its mouth. Water