Matjiesfontein surrounding Karoo region is a flat, sparsely populated semi-desert. Matjiesfontein has a healthy climate for people with lung complaints, and was once home to a Victorian spa and health resort. Matjiesfontein Matjiesfontein is a settlement in Central Karoo District Municipality in the Western Cape province of South Africa. The original inhabitants of the region were the Khoikhoi herders and the San hunter gatherers. Following the arrival of the early European colonists, the area was settled by Afrikaaner Trekboers and Griqua people. The town itself owes its existence to the Cape Government Railways, and to the route that their founder, Cape
Karoo they are the Tankwa Karoo, the Moordenaarskaroo, the Koup, the Vlakte, and the Camdeboo Plains. The Hantam, Kareeberge, Roggeveld, and uweveldare the better known subregions of the Upper Karoo, though most of it is simply known as the Upper Karoo, especially in the north. The Little Karoo’s boundaries are sharply defined by mountain ranges to the west, north, and south. The road between Uniondale and Willowmore is considered, by convention, to form the approximate arbitrary eastern extremity of the Little Karoo. Its extent is much smaller than that of the Great Karoo. Locally, it is usually called the "Klein Karoo",