Interbreeding between archaic and modern humans been shown that Neanderthal ancestry has been selected against in conserved biological pathways, such as RNA processing. Consistent with the hypothesis that purifying selection has reduced Neanderthal contribution in present-day modern human genomes, Upper Paleolithic Eurasian modern humans (such as the Tianyuan modern human) carry more Neanderthal DNA (about 4–5%) than present-day Eurasians modern humans (about 1–2%). Genes affecting keratin were found to have been introgressed from Neanderthals into modern humans (shown in East Asians and Europeans), suggesting that these genes gave a morphological adaptation in skin and hair to modern humans to cope with non-African environments. This is likewise
The Skin I Live In about to be used malevolently, assume a dreamy, otherworldly quality. "The Skin I Live In" is the work of a master near the top of his game." Upon its UK premiere, Peter Bradshaw gave it (four of five stars), calling it "fantastically twisted" and "a truly macabre suspense thriller"—"Banderas is a wonderfully charismatic leading man; Almodóvar has found in him what Hitchcock found in Cary Grant. He is stylish, debonair, but with a chilling touch of determination and menace." In an October 2011 "New York Times" Critics' Pick review, Manohla Dargis called the film "an existential mystery, a melodramatic thriller,