Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Medical tattoo a person has diabetes mellitus; people with this condition may fall into a diabetic coma and be unable to communicate that information. Tattoos have been used as fiducial markers as an aid in guiding radiotherapy. During breast reconstruction after mastectomy (removal of the breast for treatment of cancer), or breast reduction surgery, tattooing is sometimes used to replace the areola which has been removed during mastectomy, or to fill in areas of pigment loss which may occur during breast reduction performed with a free nipple graft technique. Medical tattoo A medical tattoo is a tattoo used to treat a condition,