Big Muddy National Fish and Wildlife Refuge Big Muddy National Fish and Wildlife Refuge The Big Muddy National Fish and Wildlife Refuge was established in 1994, and has grown to over . Like pearls on a string, these acres are spread out as individual units along the Missouri River between Kansas City and St. Louis. These pearls of habitat benefit floodplain-dependent fish and wildlife species. The Big Muddy Refuge is planning to grow to by buying land from willing sellers who want to see their properties set aside for the benefit of wildlife and the enjoyment of all. The pre-development Missouri River as documented by Lewis and
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