Amount of substance in use in chemical engineering in the United States is the pound-mole, having the symbol lb-mol. One pound-mole is . When quoting an amount of substance, it is necessary to specify the entity involved, unless there is no risk of ambiguity. One mole of chlorine could refer either to chlorine atoms, as in 58.44 g of sodium chloride, or to chlorine molecules, as in 22.711 liters of chlorine gas at STP. The simplest way to avoid ambiguity is to replace the term "substance" by the name of the entity or to quote the empirical formula. For example: Amount of substance
Chemical substance dissolve into solid solutions, such that a single rock is a uniform substance despite being a mixture in stoichiometric terms. Feldspars are a common example: anorthoclase is an alkali aluminum silicate, where the alkali metal is interchangeably either sodium or potassium. In law, "chemical substances" may include both pure substances and mixtures with a defined composition or manufacturing process. For example, the EU regulation REACH defines "monoconstituent substances", "multiconstituent substances" and "substances of unknown or variable composition". The latter two consist of multiple chemical substances; however, their identity can be established either by direct chemical analysis or reference to a