Decompression (diving) but in later experiments signs of what was later to become known as decompression sickness were observed. Later, when technological advances allowed the use of pressurization of mines and caissons to exclude water ingress, miners were observed to present symptoms of what would become known as caisson disease, compressed air illness, the bends, and decompression sickness. Once it was recognized that the symptoms were caused by gas bubbles, and that re-compression could relieve the symptoms, Paul Bert showed in 1878 that decompression sickness is caused by nitrogen bubbles released from tissues and blood during or after decompression, and showed the
Decompression sickness determine whether dissolved gas is taken up by tissue bubbles or circulation bubbles for bubble growth. The primary provoking agent in decompression sickness is bubble formation from excess dissolved gases. Various hypotheses have been put forward for the nucleation and growth of bubbles in tissues, and for the level of supersaturation which will support bubble growth. The earliest bubble formation detected is subclinical intravascular bubbles detectable by doppler ultrasound in the venous systemic circulation. The presence of these "silent" bubbles is no guarantee that they will persist and grow to be symptomatic. Vascular bubbles formed in the systemic capillaries may