Propolis while also collecting water and tree resin necessary for the production of propolis. The chemical composition and nature of propolis depend on environmental conditions and harvested resources. For centuries, beekeepers assumed that bees sealed the beehive with propolis to protect the colony from the elements, such as rain and cold winter drafts. However, 20th century research revealed that bees not only survive, but also thrive, with increased ventilation during the winter months throughout most temperate regions of the world. Propolis properties may include: The composition of propolis varies from hive to hive, from district to district, and from season to
Substance dependence Substance dependence Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use. A "drug addiction", a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An "addictive drug" is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral addiction and drug addictions, but not dependence. Within the framework of the 4th edition of