Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
State Institute for Drug Control on 195 reference groups of therapeutically interchangeable products of similar clinical efficacy. More than 20% of the health budget is spent on medication and medical devices. It allocates codes and names of medications for use in the electronic prescribing system. It has been criticised by KOPAC, the Patient Association for Cannabis Treatment, for failing to ensure a supply of Czech medical cannabis so that patients have to pay inflated prices for imported supplies. State Institute for Drug Control The State Institute for Drug Control (Státní ústav pro kontrolu léčiv), based in Prague is an institution of the government of the