Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Medical direction Medical direction Medical direction, or online medical direction, allows a paramedic or emergency medical technician (EMT) to contact a physician from the field via radio or other means to obtain instructions on further care of a patient. This is used particularly when a patient is in need of care that is not allowed without medical direction under the caregiver's scope of practice. For example, paramedic may be treating a burn victim in the field, and has already given the maximum amount of narcotic allowed without physician's permission. The paramedic will attempt to contact his or her base station hospital and