Ovine pulmonary adenocarcinoma as an animal model for human lung cancer, because OPA is histologically similar to human adenocarcinoma in situ of the lung. Dolly the sheep, the first mammal successfully cloned from an adult somatic cell, was euthanized after it was confirmed that she had OPA. Ovine pulmonary adenocarcinoma Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. OPA is caused by a retrovirus called jaagsiekte sheep retrovirus (JSRV). The disease has a long incubation period, and therefore signs usually occur in adult animals (over 2
King Animal would be released on November 13, 2012. Explaining the title "King Animal", Cornell declared that it relates to how the band "were a big fish in a small pond, and we sort of graduated. There was a sense of us feeling like it was us four against the world. We clearly had that from the very beginning. In some weird way after all this time, we persevered. The album kind of stands out as a symbol and an indication of that." Thayil reported that some songs sound "similar in a sense to "Down on the Upside"" and that the album