Interbreeding between archaic and modern humans been shown that Neanderthal ancestry has been selected against in conserved biological pathways, such as RNA processing. Consistent with the hypothesis that purifying selection has reduced Neanderthal contribution in present-day modern human genomes, Upper Paleolithic Eurasian modern humans (such as the Tianyuan modern human) carry more Neanderthal DNA (about 4–5%) than present-day Eurasians modern humans (about 1–2%). Genes affecting keratin were found to have been introgressed from Neanderthals into modern humans (shown in East Asians and Europeans), suggesting that these genes gave a morphological adaptation in skin and hair to modern humans to cope with non-African environments. This is likewise
The Keg of Nails 2014. Cincinnati leads the series 30–22–1. The Keg of Nails The Keg of Nails is a traveling trophy continuously-awarded to the winner of the American college football rivalry game between the Cincinnati Bearcats and Louisville Cardinals. The rivalry has stretched over the span of four conferences from the Missouri Valley Conference, to the Metro Conference to Conference USA, and more recently in the Big East Conference, which in 2013 was renamed to the American Athletic Conference. It is believed to be the oldest rivalry for the Louisville football team and the second oldest for Cincinnati, only behind the annual game