Center for Drug Evaluation and Research growing crisis around HIV testing and treatment and an inter-agency dispute between officials from the former Bureau of Drugs and officials from the former Bureau of Biologics over whether to approve Genentech's Activase (tissue plasminogen activator) led to the split. In its original form, CDER was composed of six offices: Management, Compliance, Drug Standards, Drug Evaluation I, Drug Evaluation II, Epidemiology and Biostatistics, and Research Resources. The Division of Antiviral Products was added in 1989 under Drug Evaluation II due to the large amount of drugs proposed for treating AIDS. The Office of Generic Drugs was also formed. In 2002,
Treating their pleasures. The latter solution is referred to as “treating”. Historian Kathy Peiss has popularized this term in many of her scholarly works such as "Cheap Amusements: Working Women and Leisure in Turn-of-the-Century New York" (1986) and “Charity Girls and City Pleasures” (2004). The act of treating was an exchange between a man and a woman. A man would agree to pay for a woman’s outing in exchange for her company. Treating ranged from the more innocent to the more scandalous. Treating was seen as harmless when it was conducted between a “steady” couple and more risqué when it was