Ovine pulmonary adenocarcinoma as an animal model for human lung cancer, because OPA is histologically similar to human adenocarcinoma in situ of the lung. Dolly the sheep, the first mammal successfully cloned from an adult somatic cell, was euthanized after it was confirmed that she had OPA. Ovine pulmonary adenocarcinoma Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. OPA is caused by a retrovirus called jaagsiekte sheep retrovirus (JSRV). The disease has a long incubation period, and therefore signs usually occur in adult animals (over 2
Alternatives to animal testing OECD program. The testing of chemicals is labor-intensive and expensive. Often the same chemical is tested in several countries simultaneously, which means that redundant animal tests are performed. To relieve some of this burden, the OECD Council adopted a decision in 1981, stating that data generated in a member country, in accordance with OECD Test Guidelines and Principles of Good Laboratory Practice (GLP), shall be accepted in other member countries for assessment purposes and other uses relating to the protection of human health and the environment. This principle is referred to using the acronym MAD, for the Mutual Acceptance of