Southern Illinois Southern Illinois Southern Illinois (also known as "Little Egypt") is the southern third of the state of Illinois. The southern part of Illinois has a unique cultural and regional history. Part of downstate Illinois, the Southern Illinois region is bordered by the two most voluminous rivers in the United States: the Mississippi River and its connecting Missouri River to the west, and the Ohio River to the east and south with the Wabash as tributary. Southern Illinois' most populated city is Belleville at 44,478. Other principal cities include Alton, Centralia, Collinsville, Edwardsville, Effingham, O'Fallon, Harrisburg, Herrin, Mt. Vernon, Marion, and
Muddy River (Massachusetts) flows through a conduit under Route 9 and into a narrow park called the Riverway, from which it flows through three culverts: the Riverway Culvert, the Brookline Avenue Culvert, and the Avenue Louis Pasteur Culvert. The Muddy River continues from the Fens toward its connection with the Charles River via the Charlesgate area, running through a stone-paved channel surrounded by a narrow strip of parklands. In a series of stone bridges and tunnels, it passes under Boylston Street, Massachusetts Turnpike, Commonwealth Avenue, Storrow Drive, and a series of elevated connecting ramps (the Bowker Overpass). In its natural state, the outlet