Propolis propolis has approximately 50 constituents, primarily resins and vegetable balsams (50%), waxes (30%), essential oils (10%), and pollen (5%). Propolis also contains persistent lipophilic acaricides, a natural pesticide that deters mite infestations. In neotropical regions, in addition to a large variety of trees, bees may also gather resin from flowers in the genera "Clusia" and "Dalechampia", which are the only known plant genera that produce floral resins to attract pollinators. "Clusia" resin contains polyprenylated benzophenones. In some areas of Chile and Argentina Andean valleys, propolis contains viscidone, a terpene from "Baccharis" shrubs, and in Brazil and Paraguay, naphthoquinone epoxide has
Substance dependence Substance dependence Substance dependence, also known as drug dependence, is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use. A "drug addiction", a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An "addictive drug" is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral addiction and drug addictions, but not dependence. Within the framework of the 4th edition of